Category: 3. Business

  • Novel KRAS G12D Inhibitor Shows Promising Efficacy in Advanced NSCLC

    Novel KRAS G12D Inhibitor Shows Promising Efficacy in Advanced NSCLC

    Microscopic image of non-small cell lung cancer – Generated with Google Gemini AI

    Updated clinical data from a phase 1/2 study (NCT07020221) in China of the investigational oral KRAS G12D inhibitor, VS-7375 (GFH375), have demonstrated compelling efficacy in patients with advanced non–small cell lung cancer (NSCLC) harboring a KRAS G12D mutation.1 The findings, which represent a significant increase in response rates from previously reported data, are scheduled for presentation at the IASLC 2025 World Conference on Lung Cancer (WCLC) in Barcelona, Spain. The data highlight the potential of this agent in a patient population with high unmet clinical need.

    The study, a collaboration between Verastem Oncology and GenFleet Therapeutics, provides the latest insights into the clinical profile of VS-7375, a dual “ON/OFF” KRAS G12D inhibitor. According to the late-breaking abstract, the objective response rate (ORR) at the recommended phase 2 dose of 600 mg once daily was 68.8% (n = 11/16).

    “These data at WCLC build on the encouraging data presented at [the American Society of Clinical Oncology (ASCO) Annual Meeting] earlier this year, where GenFleet initially reported an ORR of 42% in 12 patients with advanced non-small cell lung cancer harboring a KRAS G12D mutation,” said Dan Paterson, president and chief executive officer of Verastem Oncology, in a press release.

    Across all dose levels in the NSCLC cohort, the ORR was 57.7% (n = 15/26), with a disease control rate (DCR) of 88.5% (n = 23/26). All patients in the NSCLC cohort had metastatic disease at baseline, with the vast majority (64.3%) having received at least 2 prior lines of systemic therapy and nearly all (96.4%) having been previously treated with an anti–PD-1/PD-L1 agent. These patient characteristics underscore the advanced and heavily pretreated nature of the study population, making the observed response rates particularly encouraging.

    The phase 1/2 trial, initiated in July 2024, included a total of 142 patients across multiple tumor types,2 with a median follow-up time of 4.5 months as of the July 15, 2025, data cutoff.1 The study population was composed of patients with advanced NSCLC, pancreatic ductal adenocarcinoma (PDAC), and other solid tumors, with 28, 85, and 29 patients, respectively. While efficacy data were specified for the NSCLC cohort, the safety profile was reported cumulatively across all 142 patients. The safety analysis revealed that treatment-related adverse events (TRAEs) were predominantly grade 1 or 2 in severity. The most common TRAEs, occurring in at least 20% of patients, included diarrhea, vomiting, nausea, and decreased appetite. The incidence of grade 3 or higher TRAEs and severe AEs was 27.5% and 7.7%, respectively. Of the 142 patients in the safety population, 11 required dose reduction and 6 discontinued treatment due to TRAEs, with no TRAE-related deaths reported. These data suggest a manageable safety profile for VS-7375 at the doses studied.

    The KRAS G12D mutation is the most prevalent KRAS mutation, accounting for 26% of all KRAS-mutated cancers. It is particularly common in pancreatic cancer (37%) and colorectal cancer (12.5%), as well as NSCLC (5%). Despite its prevalence, there are currently no FDA-approved therapies specifically targeting this mutation. The dual “ON/OFF” mechanism of VS-7375 represents a novel approach to inhibiting both the active and inactive states of the KRAS G12D protein, distinguishing it from other agents that may only target 1 state.

    In April 2025, the FDA cleared the investigational new drug application of VS-7375.3 Last month, the FDA granted fast track designation to VS-7375 in KRAS G12D-mutated PDAC.4

    REFERENCES:
    1. Verastem Oncology Announces Late-Breaking Abstract from Partner GenFleet Therapeutics’ Study in China of GFH375 (VS-7375) in Advanced Non-Small Cell Lung Cancer at IASLC 2025 World Conference on Lung Cancer. News release. August 13, 2025. Accessed August 15, 2025. https://tinyurl.com/mr24mmuk
    2. A Phase 1/​2a Study of VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors. ClinicalTrials.gov. Updated July 18, 2025. Accessed August 15, 2025. https://clinicaltrials.gov/study/NCT07020221
    3. Verastem Oncology announces US IND clearance of VS-7375, oral KRAS G12D (ON/OFF) inhibitor, enabling phase 1/2a trial in advanced solid tumors. News release. Verastem Oncology. April 24, 2025. Accessed August 15, 2025. https://tinyurl.com/3db7zt28
    4. Verastem Oncology Granted Fast Track Designation for VS-7375 for the Treatment of KRAS G12D-mutated Locally Advanced or Metastatic Pancreatic Cancer. News release. Verastem Oncology. July 24, 2025. Accessed August 15, 2025. https://tinyurl.com/5e7ftfd9

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  • Half of Gen Z spends $0 a month on dating thanks to a ‘romance recession’

    Half of Gen Z spends $0 a month on dating thanks to a ‘romance recession’

    By Genna Contino

    The pandemic changed dating for Generation Z. Economic pressures are making it even harder.

    As the cost of living continues to rise and pandemic-fueled shifts in how people socialize linger, more than half of Gen Z is spending $0 monthly on dating, according to a Bank of America report.

    For a demographic cohort facing a high cost of living, mounting student-loan debt and job-market instability, Generation Z has not been placing a high priority on dating. Instead, it’s a financial burden.

    Data on spending habits provide a glimpse of how young folks’ mindset toward dating has shifted. About half of men (53%) and women (54%) ages 18 to 28 are spending $0 a month on dating, a recent Bank of America (BAC) report on Gen Z adults’ financial health found.

    This is likely because Gen Z has a different approach to dating compared with prior generations when their members were in the age bracket Gen Z is in now, experts say. With pandemic-fueled changes to how people socialize, alongside economic pressures fueling a pullback in young people’s spending, dating has taken a backseat for a significant portion of Gen Z. Instead, many are prioritizing economic security before rushing to find a partner, get married, have kids and buy a home, compared with past generations, who typically hit those milestones earlier in life.

    See more: TikTok’s latest budget hack is ‘dating for dinner’ – which says a lot about love and money right now

    The Gen Z dating scene has been shaped by dating apps, social media and generative AI in ways that previous generations did not experience, while a period of forced isolation during the coronavirus pandemic exacerbated young people’s reliance on online connection, which in turn altered the way they connect. A 2024 Hinge report found that Gen Z is 50% more likely than millennials to wait to answer a message from a potential match to avoid seeming overzealous, and more than half (56%) surveyed said the fear of rejection has kept them from pursuing a potential relationship.

    “We’ve seen a continual decline in dating. Some people are calling this the ‘romance recession’ or the ‘sex recession,’ particularly when we look at Gen Zs and you think of when they came of age, and dating and the pandemic hit within that,” said dating coach Damona Hoffman. “I see more people tapping out of the dating market entirely and just having anxiety about even stepping into the dating scene if they don’t have the money to date.”

    Why is half of Gen Z not spending on dating?

    About half of the Gen Z members surveyed by Bank of America said the high cost of living is a barrier to financial success. “They’re worried about groceries, worried about rent, worried about dining out,” said Will Smayda, head of financial centers at Bank of America.

    And prices are still on the rise. At the core of the consumer-price index, an inflation reading that excludes food and energy prices and is a better predictor, prices were up 0.3% in July – the sharpest monthly increase since January.

    See: Key inflation rate shows biggest rise in 6 months, CPI shows, but Fed rate cut still appears in play

    Also: Americans more worried about inflation and unemployment after new trade deals leave tariffs at highest level in decades

    Experts agree these growing financial hardships are making it hard for Gen Z to prioritize dating. And when members of the generation do decide to spend time and money on a date, they’re more deliberate with their choices.

    “We’re seeing a shift toward intentional dating, especially among younger singles,” said Michael Kaye, director of brand marketing and communications for the dating app OkCupid. “Gen Z isn’t matching for instant gratification; they’re dating with purpose and prioritizing compatibility and shared values, over flashy spending.”

    Some Gen Z-ers have chosen to tap out of the dating scene because of their own insecurities. Hoffman said she often comes across Gen Z singles who feel they are not “dateable” because of debt or a low-paying job, and a fear of being judged by potential partners keeps them from dating altogether.

    However, data suggest that these fears may be unfounded: 68% of singles surveyed by OkCupid said they would date someone who makes significantly less than them, provided that person is driven or money is not a priority for them in a relationship. Gen Z and millennials made up 90% of the survey respondents.

    People anxious about their own financial status and career might not realize that much of the dating pool is in the same boat, Hoffman said. And even if people think or say they’re looking for a partner who is rich, the person they end up connecting with might not fit that bill.

    “What they say they want on a dating app or what they are kind of aspirationally going for in a match is not necessarily all they will date,” Hoffman said.

    See more: Welcome to the real world, Class of 2025. Here are 5 money tips you haven’t heard a million times.

    These money concerns tend to loom larger for singles when a relationship is still hypothetical, Hoffman added. “When you actually make that connection and they find some commonality, the financial piece usually is not front-loaded as much as it is when somebody is thinking about dating or planning to date.”

    While these various stressors haven’t kept the entire generation from dating, they have made those who are dating more budget-conscious. Just under half of those surveyed by Bank of America said they are spending money on dating, with 28% of the total survey sample saying they spend less than $100 a month. Of the Gen Z-ers in a relationship, 43% of those not living together spent anywhere from $1 to $100 a month on dates, and 48% of cohabitating couples also fell in that range.

    Gen Z’s postpandemic dating is different from generations prior

    Along with financial pressures, the COVID-19 pandemic accelerated a trend of young people turning to online spaces for connection. While this sometimes meant engaging in solitary activities like binge-watching TV shows, it also led to a greater reliance on online communities to maintain social ties during quarantine. A Pew Research Center study, for example, found that adults under 30 were likeliest to say social-media sites helped them stay connected to friends and family during the pandemic.

    For many young people who wanted to be out and about socializing and dating, this online connection was a lifeline. However, it created a stark contrast with previous generations, which relied on in-person gatherings and phone calls to form connections, using social media as a supplement to socializing rather than as a replacement, the Pew study suggests.

    From the archives (April 2020): Online dating amid coronavirus: Longer conversations and a ‘pivot’ to video dates

    Gen Z is also the first generation to come of age during the era of generative artificial intelligence, and while generative-AI companions are growing in popularity, their impact on dating is nuanced. A third of Gen Z singles have engaged with AI as a romantic companion, compared with 16% of all American singles, a 2025 study by Match Group (MTCH) in collaboration with the Kinsey Institute found.

    “If you have Chad on your computer for free, why are you going to pay money to meet a real person who might reject you?” Hoffman said.

    This trend toward AI companionship among singles, while notable, does not provide a full picture of Gen Z’s relationship with the technology. A broader 2024 Pew Research Center survey found that the majority of adults under 30 are mostly using generative AI tools for work, learning and entertainment, rather than for romantic purposes. So while the role of AI in dating is growing, research suggests it is not a mainstream replacement for human relationships.

    Nonetheless, as Gen Z navigates evolving societal and economic pressures, a ripple effect is appearing: Dating is being delayed, which then pushes back major milestones such as marriage and homeownership.

    Young adults are prioritizing economic security over having kids, Census Bureau data show, reflecting the rising cost of living. The S&P CoreLogic Case-Shiller national home-price index, which tracks U.S. residential real-estate prices, has nearly doubled over the past decade, while annual prices for child care ranged between $6,500 and $15,600 in 2022. The cost of tuition at a four-year public university increased 36.7% between 2010 and 2023, according to the Education Data Initiative.

    See more: Home prices post smallest increase in nearly two years, Case-Shiller index says, offering buyers a reprieve

    These rising prices have served as barriers for young people looking to settle down. In 1975, 45% of people ages 25 to 34 had moved out of the house, gotten married, had children and bought a home. In 2024, just 21% of people in this age group had reached all four of these milestones.

    “Their milestones are not the same as their parents’ milestones,” Hoffman said. “The goalposts have moved.”

    See: Biggest wholesale-prices jump in three years is clearest sign yet that Trump’s tariffs are costing Americans

    Reframing a budget can help take the pressure off dating

    One promising finding from the Bank of America report about Gen Z’s financial health is that 72% of the young people surveyed took steps to improve their financial health over the past year, including putting money toward savings (51%) or paying down debt (24%).

    Gen Z-ers are also more straightforward than their older counterparts about their financial situation. They’re more likely to participate in “loud budgeting,” or openly share their budget strategies, said Smayda of Bank of America, and 42% in the report said they feel comfortable turning down a social outing if they can’t afford it.

    From the archives (January 2024): ‘Loud budgeting’ is in for 2024, TikTok users say. It’s kind of a joke – but experts say it could help you.

    (MORE TO FOLLOW) Dow Jones Newswires

    08-15-25 1411ET

    Copyright (c) 2025 Dow Jones & Company, Inc.

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  • EPBD Releases Wealth Perception Index 2025 Lists Featuring Pakistan’s Top 40 Conglomerates

    EPBD Releases Wealth Perception Index 2025 Lists Featuring Pakistan’s Top 40 Conglomerates

    ISLAMABAD – The Economic Policy & Business Development Think Tank (EPBD) has launched Pakistan’s first Wealth Perception Index 2025, ranking the country’s top 40 public and private sector conglomerates. It also includes the first-ever list of prospective dollar-billionaire business groups.

    The index, released on Pakistan’s 78th Independence Day, features 20 leading public-listed companies and 20 high-performing private groups. These operate in key sectors, including banking, cement, fertilizer, diversified manufacturing, real estate, FMCG, IT, and media.

    EPBD CEO Ahmad Nawaz Sukhera said the rankings highlight the potential of Pakistan’s private sector to lead long-term growth. He stressed that “supportive government policies and an enabling regulatory framework” are crucial for success.

    The Top Public-Listed Conglomerates Include:

    • Fauji Foundation ($5.90bn)
    • Bestway/UBL Group ($4.51bn)
    • Yunus Brothers/Lucky Group ($2.59bn)
    • Nishat Group/MCB ($2.39bn)
    • Engro Holdings ($2.39bn)
    • Meezan Bank ($2.38bn)
    • Arif Habib Group ($1.57bn)
    • Aga Khan Fund & HBL ($1.56bn)
    • Attock Group ($1.35bn)
    • British American Tobacco Pakistan ($1.24bn)

    The top 20 prospective dollar-billionaire private groups include Packages Group, Fatima Group, Sapphire Group, Hilton Pharma, Lake City Holdings, MEGA & Pioneer Cement, Jang/Geo Network, Beaconhouse Group, JDW Sugar, Artistic Group, Vision Group/Park View City, US Apparel, Liberty Group, Soorty Group, and Master Group of Industries.

    These 40 conglomerates contribute billions in tax revenue and create thousands of jobs. EPBD believes it could double its economic impact within a decade. The think tank has proposed an innovative policy: senior civil servants should complete intensive internships within these corporations to bridge the “policy-business disconnect.”

    EPBD also noted the high multiplier effects of banking, cement, fertilizer, and diversified manufacturing. It urged policymakers to prioritize these sectors in the national growth strategy.

    The report further highlights the role of women-led enterprises, technology companies like Systems Limited, and foreign-listed firms investing in Pakistan. Sukhera concluded that Pakistan has the entrepreneurial talent to achieve sustained economic transformation if the public and private sectors work in partnership.

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  • Live Event: Nuclear Power in Space

    Live Event: Nuclear Power in Space

    For more than six decades, the United States has pursued the promise of nuclear power in space — a technology capable of delivering energy where sunlight can’t reach and enabling missions beyond the limits of chemical propulsion. Yet since a brief reactor flight in 1965, no fission reactor has operated in orbit.

    Now, amid renewed competition from China and Russia, advancing reactor designs and emerging commercial interest, space nuclear power is at a crossroads. Advocates see it as essential for sustained lunar operations, crewed Mars missions, and national security in cislunar space. Critics warn of cost, complexity, and regulatory hurdles that have derailed past efforts.

    In addition, NASA leadership has prioritized a nuclear reactor on the moon.

    Join us Aug. 28 as we examine why the stakes are high, what’s changed in the past year and whether this time the technology can finally leave the launch pad.

    Jeff Foust
    Senior Staff Writer
    SpaceNews

    Bhavya Lal

    Bhavya Lal
    Former Acting Chief Technologist and Associate Administrator for Technology, Policy, and Strategy,
    NASA

    Fred Kennedy

    Fred Kennedy
    CEO And Co-Founder
    Dark Fission Space Systems

    TBA


    Register

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    Note: By registering, you consent to participate in a recorded event and receive communications from SpaceNews and our partners.

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  • Intel Jumps on Reports of White House Investment in Ohio Factory

    Intel Jumps on Reports of White House Investment in Ohio Factory

    Aug 15 – Intel (NASDAQ:INTC) jumped more than 5% on Friday after reports suggested the Trump administration is in talks to take a stake in the company. The potential investment would support Intel’s plan to build a massive semiconductor hub in Ohio, a project long touted as key to maintaining US leadership in high-end chip production.

    Details of the stake and pricing remain under discussion, and Intel has not confirmed any deal. White House spokesman Kush Desai cautioned that talks remain hypothetical, while a company spokesperson highlighted Intel’s commitment to supporting US technology and manufacturing initiatives.

    Tech analysts suggest such a move could offer Intel financial backing and strategic influence, helping the company catch up to rivals like Nvidia (NASDAQ:NVDA) and AMD (NASDAQ:AMD). Intel’s market value has dropped to roughly $104 billion since 2020, underscoring the urgency for government support.

    Observers in the industry say the Ohio plant may end up being the largest ever chip manufacturing plant globally but progress is hampered by delays. According to analysts, such as David Nicholson and Austin Lyons, the strategic use of US manufactured semi-conductors entails high demands with Intel being in a leading position to gain competence in the international market.

    This article first appeared on GuruFocus.

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  • Robots race, play football, crash and collapse at China’s ‘robot Olympics’

    Robots race, play football, crash and collapse at China’s ‘robot Olympics’

    BEIJING (Reuters) – China kicked off the three-day-long World Humanoid Robot Games on Friday, looking to showcase its advances in artificial intelligence and robotics with 280 teams from 16 countries.

    Robots competed in sports such as track and field, and table tennis, as well as tackled robot-specific challenges from sorting medicines and handling materials to cleaning services.

    Teams came from countries including the United States, Germany and Brazil, with 192 representing universities and 88 from private enterprises such as China’s Unitree and Fourier Intelligence. Competing teams used robots from Chinese manufacturers such as Booster Robotics.

    “We come here to play and to win. But we are also interested in research,” said Max Polter, a member of HTWK Robots football team from Germany, affiliated with Leipzig University of Applied Sciences.

    “You can test a lot of interesting, new and exciting approaches in this contest. If we try something and it doesn’t work, we lose the game. That’s sad, but it is better than investing a lot of money into a product that failed.”

    At the robot games in Beijing, which charged 128 to 580 yuan ($17.83-$80.77) for tickets, humanoids crashed into each other and toppled over repeatedly during football matches, while others collapsed mid-sprint during running events.

    During one football match, four robots crashed into each other and fell in a tangled heap. In the 1500-metre running event, one robot suddenly collapsed while running at full speed, drawing gasps and cheers from spectators.

    Despite frequent tumbles requiring human assistance to help robots stand, many managed to right themselves independently, earning applause from audiences.

    Organisers said the games provide valuable data collection opportunities for developing robots for practical applications such as factory work.

    Football matches help train robots’ coordination abilities, which could prove useful for assembly line operations requiring collaboration between multiple units, commentators said.

    China is investing billions of dollars in humanoids and robotics as the country grapples with an ageing population and growing competition with the U.S. over advanced technologies.

    It has staged a series of high-profile robotics events in recent months, including what it called the world’s first humanoid robot marathon in Beijing, a robot conference and the opening of retail stores dedicated to humanoid robots.

    Morgan Stanley analysts in a report last week noted a surge in attendance at a recent robot conference from the general public compared to previous years, saying this showed “how China, not just top government officials, has embraced the concept of embodied intelligence.”

     


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  • U.S. shale drillers say OPEC’s oil fight threatens growth – Cryptopolitan

    1. U.S. shale drillers say OPEC’s oil fight threatens growth  Cryptopolitan
    2. OPEC’s Strategic Oil Surge Threatens U.S. Shale Growth as Prices Tumble  Daily Times
    3. Rumors of Shale’s Peak Were Premature  Crude Oil Prices Today | OilPrice.com
    4. Opec pops US shale’s balloon  iHeart
    5. Q&A: US ‘energy independence’ more a political concept than a practical goal  Yahoo Finance

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  • The US economy is a puzzle but the pieces aren’t fitting together

    The US economy is a puzzle but the pieces aren’t fitting together

    Bloomberg/Getty A female shopper with long brown hair at the Broadway Plaza Shopping Center in Walnut Creek, California, walking on the sidewalk carrying shopping bagsBloomberg/Getty

    Ask almost any economist and they will tell you: US President Donald Trump has been running risks with the world’s largest economy.

    They say his tariffs and crackdown on immigrants risk a return of 1970s-esque “stagflation”, when a sudden oil shock prompted stagnant growth and spiralling prices, except this time the crisis would be self-inflicted.

    The White House has just as steadfastly dismissed those concerns, attacking the experts – and, in the case of the US Bureau of Labor Statistics commissioner, firing her.

    Questions about how it will all play out have left the US central bank in a state of paralysis, as it waits for data to clarify what’s happening before making a move on interest rates.

    But after a busy few weeks of company updates, data on jobs and inflation, we still don’t really know.

    The labour market is sending clearly worrisome signals.

    Job creation was almost non-existent in May and June, sluggish in July, and the ranks of discouraged workers are growing.

    That 1 August jobs report sent the stock market sinking and Trump into a tailspin, prompting him to fire the BLS commissioner.

    A few days later, Moody’s Analytics economist Mark Zandi declared on social media that the economy was “on the precipice of a recession”.

    That’s not the consensus.

    For sure, the economy has slowed, growing at an annual rate of 1.2% in the first half of the year, down one percentage point from 2024.

    But consumer spending, despite weakening, has stayed more resilient than many had expected, despite downbeat assessments by some firms.

    Shares, after the 1 August hit, quickly resumed their upward march.

    “We continue to struggle to see signs of weakness,” the chief financial officer of JPMorgan Chase, America’s biggest bank, told investors last month. “The consumer basically seems to be fine.”

    That has raised hopes that the economy might power through, as it did a few years ago, to widespread surprise, despite getting hit with the highest inflation since the 1980s and a sharp rise in interest rates.

    On Friday, the US government reported that spending at retailers and restaurants rose 0.5% from June to July – and that spending in June had been stronger than previously estimated.

    “Consumers are down but not out,” wrote Michael Pearce, deputy chief US economist at Oxford Economics, which is predicting a modest recovery in spending in the months ahead, as tax cuts and a stock market recovery boost confidence.

    “With the sluggish yet resilient real economy, the labor market is unlikely to deteriorate sharply.”

    Challenges remain in the months ahead.

    For now, households haven’t seen a dramatic run-up in prices at the store that might force them to cut back.

    Consumer prices rose 2.7% in July compared with a year ago, the same pace as in June.

    But many forecasters had not expected higher prices to start appearing until later this year, especially after Trump delayed some of his most aggressive tariff plans until this month.

    Prices for hard-to-substitute, imported staples, like coffee and bananas, have already jumped.

    Forecasters expect price increases to widen in the months ahead, as firms sell down pre-tariff stock and raise prices, now that they have more confidence about what the tariff policies might be.

    That’s why there was so much focus on the producer price index, which measures wholesale prices commanded by US producers before they hit consumers, offering a clue to what’s coming.

    It accelerated at the fastest pace in more than three years in July.

    And worryingly, both consumer and producer inflation show the uptick in prices is not limited to goods, suggesting stagflation might very well be staging a return.

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  • OGRA increases RLNG prices for August – Samaa TV

    1. OGRA increases RLNG prices for August  Samaa TV
    2. OGRA raises LNG prices for august  Daily Times
    3. Govt jacks up RLNG prices by 1.46pc  nation.com.pk
    4. OGRA announces slight increase in RLNG prices for August  Profit by Pakistan Today
    5. OGRA increases LNG prices by 1.46 percent for August  24 News HD

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  • Meta and Microsoft buy levels for investors looking to start positions

    Meta and Microsoft buy levels for investors looking to start positions

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