Category: 3. Business

A new real-world study reveals that advanced GLP-1 therapies, including semaglutide and tirzepatide, provide comparable glycemic control while offering superior weight benefits compared to metformin in adolescents newly diagnosed with type 2 diabetes.

Exploratory real-world experience with GLP-1 receptor agonists vs. metformin in youth with new-onset type 2 diabetes: a single-center retrospective study. Image Credit: Meteoritka / Shutterstock

In a recent study published in the Journal of Pediatric Endocrinology and Metabolism, researchers compared the efficacy of metformin and GLP-1–based therapies, including GLP-1 receptor agonists and the dual GIP/GLP-1 agonist tirzepatide, in youth newly diagnosed with type 2 diabetes (T2D).

Aggressive Nature and Treatment Challenges of Youth-Onset T2D

Youth-onset T2D progresses rapidly, with early onset of complications in adulthood. Metformin remains the first-line therapy for newly diagnosed pediatric patients; however, while it effectively lowers glycated hemoglobin (HbA1c), it has minimal effects on weight loss and limited durability in glycemic control. GLP-1–based therapies, already recommended in adults, are gaining traction in younger populations due to their glucose-lowering and weight-reducing effects.

Rationale for Exploring High-Potency GLP-1 Therapies

Several GLP-1 receptor agonists are approved for pediatric T2D, supported by guidelines as adjunctive treatments to metformin. Yet, approved pediatric doses yield modest weight benefits. This has prompted investigation into higher-potency GLP-1RAs and monotherapy approaches, including dual incretin agents such as tirzepatide, to assess whether stronger metabolic effects can be achieved in this age group.

Study Design and Population Characteristics

This retrospective, real-world study extracted data from electronic medical records of an urban pediatric hospital. Eligible participants were youth with newly diagnosed T2D who received GLP-1RA or metformin monotherapy between January 2022 and March 2024. Exclusion criteria included combination therapy, insulin as first-line treatment, and diabetes secondary to other causes.

Collected variables included demographics, diabetes duration, BMI, HbA1c, BMI z-scores, medication type and dose, and adverse effects. All participants were publicly insured. The primary outcomes were monthly changes in HbA1c and percent BMI within the first year post-diagnosis, with secondary outcomes assessing median changes in HbA1c, BMI, and z-scores.

Baseline Demographics and Medication Profiles

A total of 125 youth were included (median age 14.83 years), with 113 on metformin and 12 on GLP-1RA therapy. The GLP-1RA group was predominantly female (83%) compared to 51% in the metformin group, and fewer individuals identified as Latino (41.7% vs 69.9%). The most prescribed GLP-1RA was semaglutide 1 mg (33%), followed by tirzepatide 7.5 mg (25%). Higher-potency formulations (semaglutide up to 2.4 mg and tirzepatide) were used, which may account for stronger weight effects compared to pediatric trials that employed lower doses. Seven GLP-1RA recipients reported gastrointestinal adverse effects such as nausea, vomiting, and constipation.

Comparative Glycemic and Anthropometric Outcomes

Baseline HbA1c levels were similar across groups. At follow-up, unadjusted analyses showed lower HbA1c in the GLP-1RA group (36 vs 44 mmol/mol, p = 0.03), but adjusted models revealed no statistically significant monthly HbA1c change (β −1.1, p = 0.308). Median HbA1c decreased by 8.7 mmol/mol with metformin and 14.2 mmol/mol with GLP-1RA therapy.

Regarding weight outcomes, GLP-1RA recipients exhibited greater BMI reduction (−0.43 kg/m² per month) compared with metformin (−0.01 kg/m² per month). Adjusted regression analysis indicated an approximately 1% additional monthly BMI reduction with GLP-1 therapy (β = −1.08%, p = 0.001). Final percent BMI reduction was −5.1% for GLP-1RA and −0.59% for metformin, with corresponding z-score decreases of −0.02 and −0.01, respectively.

Interpretation of Efficacy and Safety Findings

At study completion, 83% of GLP-1RA users and 67% of metformin users achieved the target HbA1c of 48 mmol/mol. Although glycemic control was comparable, GLP-1RA therapy conferred superior weight reduction benefits. Adverse events were limited to gastrointestinal symptoms, consistent with the known pharmacological effects of GLP-1. The small sample size of the GLP-1RA, however, limits generalizability, and baseline BMI differences may have influenced the observed outcomes.

Study Limitations and Future Research Directions

The interpretation of the findings is limited by the small GLP-1RA cohort (n = 12), baseline imbalances in BMI and sex, the single-center retrospective design, incomplete autoantibody testing, and a median follow-up of approximately eight months. Larger, multicenter trials with balanced cohorts and extended follow-up are required to confirm comparative effects on HbA1c sustainability, beta-cell preservation, and insulin sensitivity.

BOGOTA, Colombia, Nov. 10, 2025 /PRNewswire/ — Ecopetrol S.A. (BVC: ECOPETROL; NYSE: EC) announces that it has published its first 2024 Financial Sustainability Report, in line with its commitment to transparency, sustainable value creation, and a fair and equitable energy transition for the country.

This document marks a milestone in the evolution of sustainability disclosure practices by consolidating the content previously presented separately under the recommendations of the Task Force on Climate-related Financial Disclosures (TCFD) and the metrics of the Sustainability Accounting Standards Board (SASB) into a single report, incorporating reference elements from the International Sustainability Standards Board (“ISSB“) framework.

This unified report has been implemented in response to the need to simplify, standardize, and enhance the value of sustainability information disclosed to the market. It is structured around the Ecopetrol’s pillars of governance, strategy, risk and opportunity management, metrics, and targets.

The full report is available at the following link:

https://www.ecopetrol.com.co/wps/portal/Home/sostecnibilidad/reportes-estandares/Informesgestionsostenibilidad 

Ecopetrol is the largest company in Colombia and one of the main integrated energy companies in the American continent, with more than 19,000 employees. In Colombia, it is responsible for more than 60% of the hydrocarbon production of most transportation, logistics, and hydrocarbon refining systems, and it holds leading positions in the petrochemicals and gas distribution segments. With the acquisition of 51.4% of ISA’s shares, the company participates in energy transmission, the management of real-time systems (XM), and the Barranquilla – Cartagena coastal highway concession. At the international level, Ecopetrol has a stake in strategic basins in the American continent, with Drilling and Exploration operations in the United States (Permian basin and the Gulf of Mexico), Brazil, and, through ISA and its subsidiaries, Ecopetrol holds leading positions in the power transmission business in Brazil, Chile, Peru, and Bolivia, road concessions in Chile, and the telecommunications sector.

For more information, please contact:

Head of Capital Markets
Carolina Tovar Aragón
Email: [email protected]

Head of Corporate Communications
Marcela Ulloa
Email: [email protected]

SOURCE Ecopetrol S.A.

 

Homeowners in Southeast Asia today are paying greater attention to creating modern living spaces of their very own. With increasing interest in both form and function, they are making design choices that more closely intertwine with technology, comfort, and seamless connectivity.

 

Cooling is one such aspect, which is fundamental to many Southeast Asian homes located in humid tropical climates – for instance, 2025 has been Malaysia’s hottest year in its modern history, with extreme temperatures ranging from 40°C to 45°C[1]. Meanwhile, Northern Vietnam experienced record high temperatures in August 2025, with Hanoi hitting peak temperature at 40.3°C[2]. Naturally, air-conditioners play a critical role in the modern home, providing not only essential comfort but also offering the potential to enhance design harmony and lifestyles through effortless connection, customization, and control.

 

 

Shifting Home Design and Interior Aesthetics

When it comes to home design, minimalist, open-plan homes with full-height windows and panoramic glass walls are gaining popularity amongst Southeast Asian consumers. However, these homes often feature square-shaped living areas, making it challenging to identify a suitable wall space for air conditioners without compromising on interior design.

 

 

Traditional wall-mounted air conditioners often disrupt intended aesthetics, requiring large sections of uninterrupted wall space, resulting in inflexible interior and potential clash with modern décor. It is no surprise then, that ceiling-mounted system air conditioners (SACs) are emerging as the preferred alternative.

 

As Jenny Baek, Vice-President and Head of the Air Solution Business Group at Samsung Electronics, explains: “Even if someone isn’t installing floor-to-ceiling glass, they may still want to keep their walls flexible, and system air conditioners give them that freedom”.

 

In fact, in a recent survey[3], 84% of Thai system air conditioner users expressed high satisfaction, citing effective cooling for large areas and less impact on interior aesthetics as the main benefits.

 

 

Samsung’s WindFree 1Way Cassette is an ideal choice to meet such needs. Featuring WindFree™ technology to effectively maintain a comfortable level of coolness without any unpleasant cold drafts, the air-conditioner disperses cool air through 10,000 micro air holes. Meanwhile its ultra-slim silhouette fits seamlessly into ceiling and blends effortlessly into modern interiors – freeing up walls for art, shelves or curtains and delivering clean, quiet and sleek comfort.

 

It’s evident that comfort and style are rising priorities for consumers in the region. In 2024, Samsung’s system air conditioner sales in Southeast Asia rose by over 20% from the previous year, with sales of the one-way cassette model alone jumping more than 35%.

 

 

Powering Effortless and Smart Living

Beyond design, intuitiveness, adaptiveness, and sustainable use are key for homeowners, with consumers in the Philippines citing energy efficiency and upgraded features as the two most important factors for consideration when purchasing new air-conditioners[4]. 

 

 

Equipped with built-in Wi-Fi, the WindFree 1Way Cassette works seamlessly with SmartThings to enable all-day comfort, offering centralized control over settings and performance. Working in the background, features like SmartThings Al Energy Mode can automatically adjust settings to reduce energy use by up to 20%[5] for cost and energy savings. Meanwhile, Comfort Humidity Control monitors temperature and humidity to maintain a steady indoor climate.

 

Designed to offer convenience and effortless support for daily life, the WindFree 1Way Cassette can be configured to switch on automatically when one is on the way home with Welcome Cooling[6]. It can also connect seamlessly to wearable devices like Samsung’s Galaxy Watch or Ring, to track sleep cycles and optimize room temperatures with the AI-powered Good Sleep Mode[7].

 

 

In-store Experiences to Make Informed Choices

Traditionally, system air conditioners (SACs) were installed primarily in commercial spaces such as offices, hotels, or large stores, and therefore promoted through specialized distributors or catalogues rather than in general retail environments. However, in the same Samsung research survey[8], customers – for example, those in Thailand – who expressed an intention to purchase system air conditioners also wanted the ability to see and compare them in person, at general electronics stores or large supermarkets, not just through catalogues or installers.

 

Responding to this shift, Samsung introduced in-store displays for its system air conditioners in Southeast Asia starting in June earlier this year. Shoppers can now view, compare, and purchase models directly at large electronics retailers and supermarkets. The pilot program launched in select locations in Thailand, including Siam Paragon mall, generated overwhelming consumer response.

 

 

More Southeast Asian consumers can look forward to new opportunities to explore the product portfolio, with Samsung expanding in-store SAC displays to six Southeast Asian markets including Vietnam, Indonesia, Thailand, Philippines and Malaysia this year. Interested consumers are now able to pop into participating stores to experience the technology firsthand and enjoy greater flexibility in how they cool their homes.

 

For more information, please visit: https://news.samsung.com/my/

 

 

 

[1] Climate crisis deepens as Malaysia hits 45°C

[2] Record heatwave blasts northern Vietnam

[3]  Based on the Samsung 1-way cassette AC Study in Southeast Asia conducted across two markets, Thailand and the Philippines, from November to December 2024.

[4]  Based on the Samsung 1-way cassette AC Study in Southeast Asia conducted across two markets, Thailand and the Philippines, from November to December 2024.

[5] Requires the use of SmartThings app and a Samsung account. Actual savings may vary by usage patterns and environment. Savings realized from comparison of power consumption with AI Energy Mode on and off, using AI Comfort Cooling mode at 24°C for cooling and 22°C for heating.

[6] This function may be affected by the GPS conditions.

[7] It can be used when linking a Samsung smartphone with Samsung software One Ul version 4.0 or later and a wearable device that supports Wear OS: Galaxy Watch 4 or later, Fit 3 or later, Galaxy Ring. You must download the Samsung SmartThings App on the wearable device and connect the air conditioner to your home Wi-Fi.

[8] Based on the Samsung 1-way cassette AC Study in Southeast Asia conducted across two markets, Thailand and the Philippines, from November to December 2024.

Orix will hold a 60% stake and the Qatar Investment Agency a 40% stake in the newly established fund management company, the Nikkei said.

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In its announcement, CoreWeave confirmed it nearly doubled its revenue backlog, which includes “remaining performance obligations” (RPOs) and other amounts it estimates will be recognized as revenue, to $55.6 billion, up from $30 billion the previous quarter. The surging backlog, which represents future revenues from customers, was driven by contracts with Meta, OpenAI, and French AI startup Poolside. Earnings and revenue, meanwhile, both beat analysts’ consensus estimates.

The company also reported an increase in the debt on its balance sheet, however, and it revised its full-year revenue guidance downward. Following its earnings release and call with analysts, the stock dropped 6% in after-hours trading.

Some investors have trained a gimlet eye on CoreWeave as more skeptics kick the tires of the booming AI trade and the concurrent infrastructure buildout. Concerns about CoreWeave, which some see as a potential canary-like indicator of weakness in the AI ramp-up, and about the AI build-out in general have sent the stock on a journey that has seen it tumble more than 30% from mid-August highs.

The downward revision in revenue guidance reflected delays in construction of some of CoreWeave’s data centers. “While we are experiencing relentless demand for our platform, data center developers across the industry are also enduring unprecedented pressure across supply chains,” CEO Michael Intrator said during the analysts’ call. “In our case, we are affected by temporary delays related to a third-party data-center developer who is behind schedule.”

Chief financial officer Nitin Agrawal offered full-year 2025 revenue guidance of $5.05 billion to $5.15 billion, down slightly from the guidance Intrator offered on the second-quarter earnings call, of between $5.15 billion to $5.35 billion. The customer impacted by the delay agreed to adjust the delivery schedule and extend the expiration date, Intrator said, which means CoreWeave will maintain the total value of the original contract.

Agrawal said the company’s 2025 capex spending would be between $12 billion to $14 billion, down significantly from the $20 billion to $23 billion Intrator forecast last quarter. However, Agrawal said CoreWeave expects 2026 capex to soar.

“Given the significant growth in our backlog and continued insatiable demand for our cloud services, we expect capex in 2026 to be well in excess of double that of 2025,” Agrawal said.

Revenue leaps, losses narrow, debt increases

CoreWeave reported revenues of $1.4 billion for the quarter, up from $584 million in the same quarter last year and beat analysts’ estimates. Profitability, at least by traditional GAAP measures, remains elusive. CoreWeave reported a net loss of $110 million, although it was an improvement over its $359.8 million loss in the third quarter last year and also better than analysts expected.

Adjusted net loss, which shows financial performance without extraordinary items, was $41 million for the quarter compared to the same quarter last year when it was break-even, Agrawal said. Adjusted EBITDA, which shows earnings without certain one-time expenses, were $838 million in the third quarter, compared to $379 million in Q3 2024. 

Operating income, a metric that shows profit from core businesses, fell to $51.9 million, compared to the same quarter last year when it was $117.1 million. Operating margins shrunk to 4% from 20%. 

Meanwhile, adjusted operating income, which shows a different view on core business performance, was $217 million for the third quarter, compared to $125 million in the third quarter of 2024, said Agrawal, the CFO. CoreWeave’s third quarter adjusted operating margin was 16%, due to higher revenues, lower costs, and the timing of data center deliveries from third parties.

 While Monday was just this side of positive for CoreWeave, analysts who are bearish on the AI cloud computing company remain leery of its finances. They see the company as at risk of being overwhelmed by the significant financial commitments it has taken on to build out data centers, which currently look disproportionately large compared to its revenues and cash flow. Based on its latest earnings release, CoreWeave has $9.7 billion in bills due within the next 12 months on its balance sheet, and a total of $14 billion in current and longer-term debt. Last quarter, those figures were $7.6 billion and $11 billion, respectively. 

CoreWeave also has $34 billion in scheduled lease payments on contracts that will commence between now and 2028. Interest expense reached $311 million for the quarter, nearly triple the figure from the year-earlier period, of $104 million. 

CoreWeave bulls, meanwhile, remain confident that revenues from the company’s book of contracts will eventually far outstrip its debt obligations. During the past three months, CoreWeave has announced a spate of significant deals, booking a $14.2 billion deal to provide Meta with computing capacity and an agreement with Poolside for a data center with 40,000 of Nvidia’s coveted GPUs.

Nov 10 (Reuters) – Boeing (BA.N), opens new tab received approval last week from the U.S. Federal Aviation Administration to begin the third of five major phases of certification flight tests for its 777-9, the Air Current reported on Monday, citing people familiar with the program’s progress.

Reporting by Rishabh Jaiswal in Bengaluru; Editing by Sherry Jacob-Phillips

Global law firm Clyde & Co today announced the appointment of Kirsten Wilkerson as a partner in its Washington, DC, office. Her arrival marks a strategic expansion of the firm’s North American Trial & Defense practice, reinforcing Clyde & Co’s position as a leading legal advisor to the insurance sector and deepening its litigation capabilities in a key market.

Kirsten Wilkerson is a seasoned litigator with 25 years of experience defending complex, high-value, and emerging tort claims. Her practice spans personal injury, mass torts, toxic exposure, and premises liability, among other areas. She also has extensive mediation experience, having negotiated structured settlements in complex cases across the country. 

Eileen King Bower, Partner and Chair of Clyde & Co’s North American Board commented: “Kirsten brings a proven ability to craft and execute litigation strategies in some of the most complex and high-stakes cases. Her appointment reflects our ongoing commitment to expanding our insurance capabilities across the US and will further enhance our ability to deliver outstanding service and results for our clients.”

Kirsten Wilkerson commented: “Joining Clyde & Co offers an exciting opportunity to contribute to its highly respected Trial & Defense practice. My experience handling complex tort claims, from environmental and toxic exposure to premises liability, aligns closely with the firm’s strategic focus. I’m looking forward to working alongside talented colleagues across the firm and helping clients navigate the challenges of high-stakes litigation.”

Clyde & Co is a leading global law firm with a robust North American practice that offers clients industry-leading advisory and dispute resolution services. The firm opened its first North American office in New York in 2006. Since then, the firm has grown to 19 offices with more than 400 attorneys across the US and Canada, including more than 100 partners.

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About Clyde & Co

Clyde & Co is a leading global law firm, helping organizations navigate risk and maximize opportunity in the sectors that underpin global trade and commercial activity, namely: insurance, aviation, marine, construction, energy, trade and natural resources. Globally integrated, the firm has 500 partners, 2,400 lawyers, 3,200 legal professionals and 5,500 people overall in over 70 offices and associated offices worldwide. For more information please visit www.clydeco.com.