Category: 3. Business

  • Banks bet big on fossil fuels, boosting financing in 2024, report finds – Mongabay

    1. Banks bet big on fossil fuels, boosting financing in 2024, report finds  Mongabay
    2. What role does your money play in the climate crisis?  Times of India
    3. Fire hazard: Funding the burning of fossil fuels will eventually leave bank money burnt  Mint
    4. Coal Loophole Undermines Bank Pledges to Cut Fossil-Fuel Funding  Bloomberg.com
    5. Are banks lying to us?  Finshots

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  • WestJet and Saudia announce interline agreement unlocking enhanced international connectivity to more than 100 destinations

    WestJet and Saudia announce interline agreement unlocking enhanced international connectivity to more than 100 destinations

    WestJet and Saudia announce interline agreement unlocking enhanced international connectivity to more than 100 destinations

    WestJet guests to gain single-connection access to multiple points in the Kingdom of Saudi Arabia for the first time

    CALGARY, AB, June 30, 2025 /CNW/WestJet today announced a new interline partnership agreement with Saudia, significantly enhancing global connectivity across both carriers’ networks. The agreement includes single-connection access to Jeddah via Toronto Pearson as well as both Jeddah and Riyadh from London Heathrow and Paris Charles-de-Gaulle.

    “An interline partnership with Saudia marks a major step forward in expanding global connectivity for our guests,” said John Weatherill, WestJet Executive Vice-President and Chief Commercial Officer. “This agreement not only provides WestJet guests with seamless single-connection access to Saudia’s extensive global network but also strengthens inbound tourism and business links. Together, WestJet and Saudia are creating more convenient and diverse travel options for guests on both sides, fostering stronger connections and collaboration across continents.”

    Arved von zur Muehlen, Chief Commercial Officer at Saudia, said, “We value the partnership with WestJet, it reflects Saudia’s commitment to offer our guests more destinations through key international gateways. Canada is now closer than ever, and we are also offering a seamless journey for travellers from Canada to explore Saudi Arabia and experience its unique culture, heritage, and hospitality.”

    The agreement was signed by Arved von zur Muehlen, Chief Commercial Officer at Saudia, and John Weatherill, Executive Vice-President and Chief Commercial Officer at WestJet.

    Guests can now book a single ticket with a connected itinerary between WestJet and Saudia’s networks with single point check-in and through-checked bags. Bookings will be available through a travel agent or third-party ticket sales websites.

    About WestJet      
    WestJet took to the skies in 1996 with just over 200 employees and three aircraft operating service to five destinations. Since then, WestJet has pioneered low-cost travel in Canada, cutting airfares in half, and increasing the flying population in Canada by more than 50 per cent. Following integration with Sunwing in 2025, more than 14,000 WestJetters support nearly 200 aircraft and connect guests to more than 100 destinations across North America, Central America, the Caribbean, Europe and Asia.    

    As a major Canadian employer that includes WestJet Airlines, Sunwing Vacations Group and WestJet Cargo, the WestJet Group is Canada’s leading low-cost airline and largest vacation provider, with a united purpose of providing affordable and accessible air and vacation travel to Canadians.    

    Learn more about WestJet at westjet.com/en-ca/who-we-are (also available in French)  

    Follow WestJet on Facebook at facebook.com/westjet   
    Follow WestJet on X at x.com/westjet and x.com/WestJetNews   
    Follow WestJet on Instagram at instagram.com/westjet/   
    Subscribe to WestJet on YouTube at youtube.com/westjet    

    SOURCE WESTJET, an Alberta Partnership


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  • Siemens and EnPot join forces to power China’s aluminium industry using renewables – News

    Siemens and EnPot join forces to power China’s aluminium industry using renewables – News

    EnPot’s technology preserves the electrochemical process of aluminium production while allowing smelters to modulate energy by up to 30%

    SIEMENS has signed a deal with EnPot, developer of a novel heat exchange technology, to help China’s huge aluminium industry use more renewable power.

    EnPot, a New Zealand-based process development company, has developed a technology that allows aluminium smelters to modulate their power use. This would open the door for smelters to reduce their reliance on more dependable fossil fuels while contributing to grid stability.

    Traditional smelter design requires a constant power supply to sustain the electrochemical reaction that produces aluminium and to maintain the heat balance within the pots – a reduction in power can cause severe damage.

    EnPot’s technology uses a mechanical system of heat exchangers that preserve the electrochemical process while allowing smelters to modulate energy by up to 30% without disrupting the internal heat balance. This makes smelting more compatible with variable supplies of renewable power.

    Siemens Energy designs energy management systems that integrate renewable power generation into existing facilities and optimise power use. Together the partners aim to help manufacturers integrate more renewable energy, improve energy efficiency and reduce operating costs.

    China has strict targets for renewable energy to power 30% of its aluminium industry by 2027.

    Karyna Young, CEO of EnPot, said: “China boasts more than 55% of the world’s aluminium smelters and counting. Like the rest of the world, they also see an urgent need to power the process with more energy from the sun, wind and lakes.

    “This means they need to produce aluminium more flexibly by turning power consumption up or down on demand to match the availability of renewables. Numerous smelters in China have told our team they have an abundance of renewable energy that is next to impossible to take full advantage of without being able to dynamically balance the heat in the pots.”

    EnPot’s technology was commercialised at a smelter in Essen, Germany in 2014 and expanded to a full potline of 120 pots in 2019.

    For more on the technology, read a feature written by its developers.

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  • Carnival Cruise Line and The Coca-Cola Company Are Getting Back Together!

    Carnival Cruise Line and The Coca-Cola Company Are Getting Back Together!

    “We’re thrilled to be back on board with Carnival, literally! From an ice-cold Coca-Cola with lunch, a Topo Chico by the pool, or a Powerade after exploring a destination, we’ll have the perfect drink for every moment of the journey,” said Dagmar Boggs, president, Foodservice & On-Premise, The Coca-Cola Company, North American Operating Unit. “This partnership is all about enhancing the guest experience, and we’re thrilled to offer a beverage lineup as diverse and exciting as the adventures Carnival guests embark on.”

    Carnival anticipates the partnership will be fully integrated across its North American fleet by the end of September 2025. Carnival ships in Australia already serve Coca-Cola beverages.

    For additional information on Carnival Cruise Line and to book a cruise vacation on Carnival, call 1-800-CARNIVAL, visit http://www.carnival.com, or contact your favorite travel advisor or online travel site.

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  • Affordability a ‘formidable challenge’ as load shifts to tech, industrial customers: ICF

    Affordability a ‘formidable challenge’ as load shifts to tech, industrial customers: ICF

    Dive Brief:

    • Keeping electricity affordable for consumers is a “formidable challenge” amid projections of declining generation capacity reserves and persistent uncertainty around the scale and pace of future load growth, ICF International Vice President of Energy Markets Maria Scheller said Thursday. 
    • Meanwhile, broad policy uncertainty and an increasingly shaky regulatory environment give utilities and capital markets pause about expensive new infrastructure investments that could become stranded assets, Scheller said in a webinar on ICF’s “Powering the Future: Addressing Surging U.S. Electricity Demand” report.
    • Policy conversations around import tariffs, federal energy tax credits and permitting reform are unfolding as the balance of electricity demand shifts from residential and business consumers to technology and industrial customers, which tend to require around-the-clock power, Scheller added.

    Dive Insight:

    The coming shift in U.S. electricity consumption represents less of a new paradigm than a return to the industrial-driven demand the country saw from the 1950s into the 1980s, after which deindustrialization and consumer-centric trends like the widespread adoption of air conditioning, electric resistance heating and personal computing shifted the balance toward the residential segment, Scheller said.

    The shift is important because unlike residential loads, which show considerable seasonal and intraday variation, industrial loads are flatter, less weather-dependent and more sensitive to voltage fluctuations, Scheller said.

    By 2035, ICF expects nearly 40% of total U.S. load will have a “flat, power-quality-sensitive profile,” and that overall load will grow faster than peak load, she said. In 2030, ICF projects more than 3% annual power consumption growth, compared with less than 2% annual peak load growth, according to a webinar slide.

    That’s not to say residential demand won’t also grow in the next few years as consumers electrify home heating and buy more electric vehicles — only that data centers and other industrial demand will “dwarf” it, Scheller said.

    The only significant regional exception to that expectation is California, where ICF says light- and heavy-duty transportation electrification will drive most load growth through 2040. 

    Capacity reserves will quickly dwindle across most of the United States as a result of near-term load growth, regardless of the regional drivers, said Lalit Batra, ICF director of energy markets.

    “We expect the capacity reserve across most regions to be absorbed in the next few years,” Batra said.

    ICF sees nationwide capacity reserves — currently between 20% and 25% — below the 15% target reserve margin by 2030 and in negative territory by 2035, according to a webinar slide. Without a meaningful acceleration in new generation deployment, some combination of delayed power plant retirements, load flexibility or slower overall load growth will be needed to avoid shortages, Batra said.

    Building new power plants fast enough to keep pace with load growth will be more difficult if Republicans in Congress effectively repeal the Inflation Reduction Act, according to ICF’s projections. If the final budget reconciliation bill preserves the rapid phaseout of clean energy tax credits in the version the U.S. House of Representatives passed in May, ICF projects the U.S. would deploy 280 GW fewer renewables and storage capacity and 43 GW more gas and nuclear through 2040, even as cost-competitiveness, supportive state policy and corporate power buyers’ preference for clean electricity supports robust regional markets for those technologies. 

    Regardless of the policy scenario, ICF expects electricity prices to rise as much as 25% in some regions through 2030 due to necessary grid expansion, wildfire hardening and other infrastructure projects, along with gas price volatility, said Deb Harris, ICF vice president for climate change and sustainability. ICF expects U.S. gas prices to be 7% higher in 2035 and 17% higher in 2045 if the House budget becomes law relative to a status-quo scenario, according to a webinar slide.

    Utilities and regulators already have the tools to mitigate some of these changes, Harris said. For example, demand response programs and flexible load interconnection could avoid about 30% of infrastructure investment costs that would otherwise be necessary, Harris said. Large loads are more open than some realize to ramping down load or investing in more efficient processes, such as liquid rather than air cooling of server racks, she added.

    “These large load customers do offer a lot of opportunities” for efficiency and demand response, she said. “Energy is the number one [operating] cost they face.”

    Permitting reforms like uniform siting standards, incentives for brownfield redevelopment and wider adoption of advanced GIS tools to locate “areas of minimal impact” for energy development could speed up new builds and keep prices in check, Harris added.

    The catch, she said, is that while efforts to mitigate rising electricity prices may benefit customers and the politicians who represent them, project developers and their lenders and investors want to see durable price signals before committing to build new generation and transmission.

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  • Elraglusib Shows Promising OS in Metastatic Pancreatic Cancer Subgroups

    Elraglusib Shows Promising OS in Metastatic Pancreatic Cancer Subgroups

    Pancreatic cancer anatomy concept: © Лилия Захарчук – stock.adobe.com

    New data from a prespecified subgroup analysis of the phase 2 Actuate-1801 part 3B trial (NCT03678883) highlight the potential of elraglusib (9-ING-41), an investigational glycogen synthase kinase-3 beta (GSK-3β) inhibitor, in combination with gemcitabine/nab-paclitaxel (GnP) for first-line metastatic pancreatic adenocarcinoma (mPDAC) treatment.1

    The findings indicate a notable improvement in overall survival (OS) among patients receiving at least 1 complete cycle of elraglusib in conjunction with standard chemotherapy, particularly within the challenging subgroup of patients with liver metastases.

    For patients who completed at least one 4-week cycle of therapy, the elraglusib/GnP combination arm achieved a median OS of 12.5 months compared with 8.5 months in the control arm. This represented a 43% reduction in the risk of death relative to the control group, underscoring the potential for early disease control with elraglusib.

    Beyond OS, the combination therapy also demonstrated improved outcomes across several other key efficacy metrics. The disease control rate (DCR) was 53.4% in the elraglusib arm vs 44.8% in the control arm, while the overall response rate (ORR) improved to 37.9% compared with 29.3%. Median progression-free survival (PFS) was 6.9 months with elraglusib, an improvement over 5.6 months in the control group.

    A particularly impactful finding emerged from the analysis of patients with liver metastases; a subpopulation historically associated with an exceptionally poor prognosis in mPDAC. In this group, treatment with elraglusib led to a 2.5-fold increase in 1-year OS and a 38% reduction in the risk of death compared to the control arm. While the GnP control arm showed 0% OS probability at 18 months, patients receiving elraglusib maintained a survival probability of 13.6% OS at 18 months. Additional efficacy metrics within this liver metastases subgroup further supported these observations: DCR was 36.8% vs 27.9%, ORR was 29.8% vs 19.7%, and PFS was 4.9 months vs 3.9 months in the elraglusib and control arms, respectively. The pronounced benefit observed in this high-risk population highlights elraglusib’s potential to address a critical unmet need.

    “We are highly encouraged by the significant clinical benefit provided by elraglusib demonstrated in this study,” said Daniel Schmitt, president and chief executive officer of Actuate Therapeutics, in a press release. “These results underscore the potential of elraglusib to generate rapid and durable benefit in high-risk patients, which could be highly impactful in future development and commercial pathways.”

    mPDAC represents an advanced and aggressive disease and accounts for approximately 90% of all pancreatic cancers. It is widely recognized as one of the deadliest malignancies, with a 5-year survival rate for metastatic cases under 10%.2 This prognosis underscores the urgent need for novel and more effective therapeutic strategies.

    Elraglusib’s mechanism of action involves the inhibition of GSK-3β, a serine/threonine protein kinase implicated in numerous cellular processes, including cell proliferation, differentiation, and survival.1 GSK-3β plays a complex role, often promoting tumor growth and contributing to resistance against conventional cancer therapies, such as chemotherapy. By inhibiting GSK-3β, elraglusib aims to disrupt key molecular pathways in cancer that are involved in promoting tumor growth and resistance. Specifically, its activity targets pathways such as NF-kB of activated B cells and the DNA damage response.

    Furthermore, preliminary research suggests elraglusib may also mediate antitumor immunity through the regulation of multiple immune checkpoints and immune cell function, potentially enhancing the body’s natural defenses against cancer. These multifaceted effects contribute to the drug’s observed clinical benefits.

    REFERENCES:
    1. Actuate Therapeutics highlights significant and sustained survival benefit in key metastatic pancreatic cancer patient populations in phase 2 elraglusib trial. News release. Actuate Therapeutics. June 24, 2025. Accessed June 26, 2025. https://tinyurl.com/muyufn2j
    2. Sarantis P, Koustas E, Papadimitropoulou A, et al. Pancreatic ductal adenocarcinoma: treatment hurdles, tumor microenvironment and immunotherapy. World J Gastrointest Oncol. 2020;12(2):173-181. doi:10.4251/wjgo.v12.i2.173

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  • AMGEN ANNOUNCES POSITIVE TOPLINE PHASE 3 RESULTS FOR BEMARITUZUMAB IN FIBROBLAST GROWTH FACTOR RECEPTOR 2b (FGFR2b) POSITIVE FIRST-LINE GASTRIC CANCER| Amgen

    AMGEN ANNOUNCES POSITIVE TOPLINE PHASE 3 RESULTS FOR BEMARITUZUMAB IN FIBROBLAST GROWTH FACTOR RECEPTOR 2b (FGFR2b) POSITIVE FIRST-LINE GASTRIC CANCER| Amgen

    At an Interim Analysis, Bemarituzumab Plus Chemotherapy Significantly Improved Overall Survival in People With FGFR2b Overexpression Compared to Chemotherapy Alone

    THOUSAND OAKS, Calif., June 30, 2025 /PRNewswire/ — Amgen (NASDAQ:AMGN) today announced the Phase 3 FORTITUDE-101 clinical trial evaluating first-line bemarituzumab plus chemotherapy (mFOLFOX6) met its primary endpoint of overall survival (OS) at a pre-specified interim analysis. 

    Bemarituzumab plus chemotherapy demonstrated a statistically significant and clinically meaningful improvement in OS as compared to placebo plus chemotherapy in people living with unresectable locally advanced or metastatic gastric or gastroesophageal junction (G/GEJ) cancer with FGFR2b overexpression and who are non-HER2 positive. FGFR2b overexpression was defined as 2+/3+ staining in ≥10% of tumor cells by centrally performed immunohistochemistry (IHC) testing.

    Gastric cancer is the fifth leading cause of cancer-related death worldwide, with nearly one million new cases and over 650,000 deaths globally each year 1, highlighting a critical unmet medical need.

    “Most patients with gastric cancer are diagnosed at an advanced stage, with poor prognosis, low survival rates and limited therapeutic options,” said Jay Bradner, M.D., executive vice president of Research and Development at Amgen. “These first positive top-line results of an FGFR2b targeted monoclonal antibody from our Phase 3 FORTITUDE-101 study mark a meaningful advance in the development of effective targeted therapy for gastric cancer.”

    The most common treatment-emergent adverse events (>25%) in patients treated with bemarituzumab plus chemotherapy were reduced visual acuity, punctate keratitis, anaemia, neutropenia, nausea, corneal epithelium defect and dry eye. While ocular events were consistent with the Phase 2 experience and observed in both arms, they occurred with greater frequency and severity in the Phase 3 bemarituzumab arm.

    Detailed results from the trial will be shared at a future medical meeting.

    FORTITUDE-101 was conducted with the support of Zai Lab. Zai Lab holds co-development and commercialization rights for bemarituzumab for mainland China, Hong Kong, Macau, and Taiwan.

    A Phase 3 study of bemarituzumab plus chemotherapy and nivolumab is also ongoing in patients with first-line gastric cancer, with a data readout anticipated in H2 2025.

    About FGFR2b 
    The FGFR2b protein (also known as fibroblast growth factor receptor 2b) is an emerging biomarker which, when overexpressed, promotes aberrant signaling leading to tumor cell proliferation.2

    The FGFR2b protein is overexpressed by G/GEJ tumor cells in approximately 38% of patients with advanced G/GEJ cancer. FGFR2b protein overexpression is defined as 2+/3+ staining intensity on tumor cell membrane, as detected by immunohistochemistry (IHC) testing. In approximately 16% of patients with advanced G/GEJ cancer, FGFR2b protein overexpression is observed on ≥10% of tumor cells by IHC.3

    About FORTITUDE-101 
    FORTITUDE-101 is a randomized, multi-center, double-blind, placebo-controlled Phase 3 study of bemarituzumab plus mFOLFOX6 versus placebo plus mFOLFOX6 as first-line therapy in advanced G/GEJ cancer with FGFR2b overexpression. The FORTITUDE-101 trial spanned 300 sites across 37 countries, with 547 patients enrolled.

    The primary outcome measure of the trial is overall survival in patients with FGFR2b ≥10% 2+/3+ tumor cell staining.  Key secondary outcome measures include progression-free survival and overall response rate. Candidates were excluded from the trial if they were known to be human epidermal growth factor receptor 2 (HER2) positive. FORTITUDE-101 included more comprehensive ocular-related monitoring than previous studies of bemarituzumab.

    About Amgen
    Amgen discovers, develops, manufactures and delivers innovative medicines to help millions of patients in their fight against some of the world’s toughest diseases. More than 40 years ago, Amgen helped to establish the biotechnology industry and remains on the cutting-edge of innovation, using technology and human genetic data to push beyond what’s known today. Amgen is advancing a broad and deep pipeline that builds on its existing portfolio of medicines to treat cancer, heart disease, osteoporosis, inflammatory diseases and rare diseases.

    In 2024, Amgen was named one of the “World’s Most Innovative Companies” by Fast Company and one of “America’s Best Large Employers” by Forbes, among other external recognitions. Amgen is one of the 30 companies that comprise the Dow Jones Industrial Average®, and it is also part of the Nasdaq-100 Index®, which includes the largest and most innovative non-financial companies listed on the Nasdaq Stock Market based on market capitalization.

    For more information, visit Amgen.com and follow Amgen on X, LinkedIn, Instagram,  YouTube and Threads. 

    Amgen Forward-Looking Statements

    This news release contains forward-looking statements that are based on the current expectations and beliefs of Amgen. All statements, other than statements of historical fact, are statements that could be deemed forward-looking statements, including any statements on the outcome, benefits and synergies of collaborations, or potential collaborations, with any other company (including BeOne Medicines Ltd. or Kyowa Kirin Co., Ltd.), the performance of Otezla® (apremilast), our acquisitions of ChemoCentryx, Inc. or Horizon Therapeutics plc (including the prospective performance and outlook of Horizon’s business, performance and opportunities, and any potential strategic benefits, synergies or opportunities expected as a result of such acquisition), as well as estimates of revenues, operating margins, capital expenditures, cash, other financial metrics, expected legal, arbitration, political, regulatory or clinical results or practices, customer and prescriber patterns or practices, reimbursement activities and outcomes, effects of pandemics or other widespread health problems on our business, outcomes, progress, and other such estimates and results. Forward-looking statements involve significant risks and uncertainties, including those discussed below and more fully described in the Securities and Exchange Commission reports filed by Amgen, including our most recent annual report on Form 10-K and any subsequent periodic reports on Form 10-Q and current reports on Form 8-K. Unless otherwise noted, Amgen is providing this information as of the date of this news release and does not undertake any obligation to update any forward-looking statements contained in this document as a result of new information, future events or otherwise.

    No forward-looking statement can be guaranteed and actual results may differ materially from those we project. Discovery or identification of new product candidates or development of new indications for existing products cannot be guaranteed and movement from concept to product is uncertain; consequently, there can be no guarantee that any particular product candidate or development of a new indication for an existing product will be successful and become a commercial product. Further, preclinical results do not guarantee safe and effective performance of product candidates in humans. The complexity of the human body cannot be perfectly, or sometimes, even adequately modeled by computer or cell culture systems or animal models. The length of time that it takes for us to complete clinical trials and obtain regulatory approval for product marketing has in the past varied and we expect similar variability in the future. Even when clinical trials are successful, regulatory authorities may question the sufficiency for approval of the trial endpoints we have selected. We develop product candidates internally and through licensing collaborations, partnerships and joint ventures. Product candidates that are derived from relationships may be subject to disputes between the parties or may prove to be not as effective or as safe as we may have believed at the time of entering into such relationship. Also, we or others could identify safety, side effects or manufacturing problems with our products, including our devices, after they are on the market.

    Our results may be affected by our ability to successfully market both new and existing products domestically and internationally, clinical and regulatory developments involving current and future products, sales growth of recently launched products, competition from other products including biosimilars, difficulties or delays in manufacturing our products and global economic conditions, including those resulting from geopolitical relations and government actions. In addition, sales of our products are affected by pricing pressure, political and public scrutiny and reimbursement policies imposed by third-party payers, including governments, private insurance plans and managed care providers and may be affected by regulatory, clinical and guideline developments and domestic and international trends toward managed care and healthcare cost containment. Furthermore, our research, testing, pricing, marketing and other operations are subject to extensive regulation by domestic and foreign government regulatory authorities. Our business may be impacted by government investigations, litigation and product liability claims. In addition, our business may be impacted by the adoption of new tax legislation or exposure to additional tax liabilities. Further, while we routinely obtain patents for our products and technology, the protection offered by our patents and patent applications may be challenged, invalidated or circumvented by our competitors, or we may fail to prevail in present and future intellectual property litigation. We perform a substantial amount of our commercial manufacturing activities at a few key facilities, including in Puerto Rico, and also depend on third parties for a portion of our manufacturing activities, and limits on supply may constrain sales of certain of our current products and product candidate development. An outbreak of disease or similar public health threat, and the public and governmental effort to mitigate against the spread of such disease, could have a significant adverse effect on the supply of materials for our manufacturing activities, the distribution of our products, the commercialization of our product candidates, and our clinical trial operations, and any such events may have a material adverse effect on our product development, product sales, business and results of operations. We rely on collaborations with third parties for the development of some of our product candidates and for the commercialization and sales of some of our commercial products. In addition, we compete with other companies with respect to many of our marketed products as well as for the discovery and development of new products. Further, some raw materials, medical devices and component parts for our products are supplied by sole third-party suppliers. Certain of our distributors, customers and payers have substantial purchasing leverage in their dealings with us. The discovery of significant problems with a product similar to one of our products that implicate an entire class of products could have a material adverse effect on sales of the affected products and on our business and results of operations. Our efforts to collaborate with or acquire other companies, products or technology, and to integrate the operations of companies or to support the products or technology we have acquired, may not be successful. There can be no guarantee that we will be able to realize any of the strategic benefits, synergies or opportunities arising from the Horizon acquisition, and such benefits, synergies or opportunities may take longer to realize than expected. We may not be able to successfully integrate Horizon, and such integration may take longer, be more difficult or cost more than expected. A breakdown, cyberattack or information security breach of our information technology systems could compromise the confidentiality, integrity and availability of our systems and our data. Our stock price is volatile and may be affected by a number of events. Our business and operations may be negatively affected by the failure, or perceived failure, of achieving our sustainability objectives. The effects of global climate change and related natural disasters could negatively affect our business and operations. Global economic conditions may magnify certain risks that affect our business. Our business performance could affect or limit the ability of our Board of Directors to declare a dividend or our ability to pay a dividend or repurchase our common stock. We may not be able to access the capital and credit markets on terms that are favorable to us, or at all.

    The scientific information discussed in this news release related to our product candidates is preliminary and investigative. Such product candidates are not approved by the U.S. Food and Drug Administration, and no conclusions can or should be drawn regarding the safety or effectiveness of the product candidates.

    CONTACT: Amgen, Thousand Oaks Elissa Snook, 609-251-1407 (media)Justin Claeys, 805-313-9775 (investors) 

    REFERENCES

    1. Bray F, et al. CA Cancer J Clin. 2024;74(3);229-263
    2. Wainberg ZA, et al. Lancet Oncol. 2022;23(11):1430-40
    3. Rha SY, et al. JCO Precis Oncol. 2025; 9 (e2400710). DOI:10.1200/PO-24-00710

     

    Cision View original content to download multimedia:https://www.prnewswire.com/news-releases/amgen-announces-positive-topline-phase-3-results-for-bemarituzumab-in-fibroblast-growth-factor-receptor-2b-fgfr2b-positive-first-line-gastric-cancer-302494006.html

    SOURCE Amgen


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  • Limiting user fees for subsidised energy generation plants

    Limiting user fees for subsidised energy generation plants

    “The Federal Government will probably try to link the payment of EEG feed-in tariffs to operators of energy plants to certain minimum requirements for the land use agreements.”

    But what kind of regulation could stipulate the maximum usage fees and how should they be fixed over the lengthy term of usage contracts, usually set for 30 years? A ‘user fee audit’ with an annual review of the amounts paid would result in too much administrative work and be impractical. However, due to the text form requirements of the usage contracts, it could be sufficient for participants in EEG auctions to make a binding commitment to the Federal Network Agency to comply with certain standards. This would ensure no increase in user fees (that have not already been laid out) could be made during the contract term without operator consent. Whether further controls are necessary remains to be seen in practice. Due to the widespread due diligence checks by buyers and financing banks, a market standard should quickly emerge that places importance on complying with these requirements to secure a long-term EEG feed-in tariff.

    The state already has experience with the limitation of remuneration under lease agreements – namely rent brake. Whilst these are very different subject matters – rent brake is intended to counteract the displacement of lower income groups from high-demand residential areas – nonetheless, certain aspects of this measure are comparable. For example, the rent brake’s framework includes mechanisms to decide at what point an apartment’s rent is considered excessive. Similar mechanisms could be used to take action against excessive usage fees.

    What could a limitation model for usage fees look like? Currently there is no ‘energy investment index’. Will there be certain administrative categories or certain value criteria for wind and solar areas in the future? From an operator/developer’s point of view, road and grid connection conditions on site, as well as wind, light and ground conditions would be of interest in determining charges. So far, the German Wind Energy Association (“BWE”) has remained somewhat unprecise on this point: in his view, the link to the tender and the correct control mechanism are “important” for the implementation of the limitation model of usage fees. The BWE prefers a model with a loss of the acceptance of a bid in the auction for EEG feed-in tariffs in the event of violation of a reference remuneration. It therefore remains to be seen which criteria the legislator will consider permissible and how a ‘reference remuneration’ could be determined for regional areas.

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  • German premiere with live flight demonstration: German industry team showcases electromagnetic combat from the air

    German premiere with live flight demonstration: German industry team showcases electromagnetic combat from the air

    In the live flight demonstration in Manching, the team of German defense companies simulated a scenario close to real operations in front of numerous representatives of the German Armed Forces: the evacuation of German citizens from a crisis area equipped with comprehensive air defense systems. A Pilatus PC-12 turboprop aircraft, a simulated Airbus A400M military airlifter, a SHARCS technology demonstrator serving as an unmanned remote carrier, and an SA-8 air defense missile system representing the enemy’s air defense were used.

    The PC-12 was equipped with an electromagnetic surveillance and jamming system. It acted as a stand-off jammer, or jamming aircraft, which detected and classified the SA-8 system from a safe distance, jammed it with electromagnetic countermeasures, and rendered it incapable of combat. Without functioning enemy air defenses, the simulated A400M was able to fly into the crisis area undetected, land, and evacuate citizens.

    The SHARCS remote carrier, equipped with a stand-in jammer, provided support by simultaneously suppressing communications, thereby delaying a response from enemy forces. The seamless communication between friendly forces, the exchange of reconnaissance and effect data, and the processing and AI-supported analysis of the data took place in a secure cloud.

    The demonstration showed how effectively forces of electromagnetic combat (EC) can operate and protect friendly forces during missions. Since EC operates without ammunition and is non-kinetic, there is also no damage.

    The capability demonstrated in the demonstration is an essential component of the German defense project “luftgestützte Wirkung im elektromagnetischen Spektrum” (Airborne Effects in the Electromagnetic Spectrum), or luWES for short, in which the German Armed Forces are building up EC capabilities. Developing the technologies for this is the declared goal of Airbus, bKEC, HENSOLDT, IBM, MBDA, PLATH, Rohde & Schwarz, and Schönhofer. Under the motto “EC made in Germany for Germany,” they want to enable the German Air Force to deploy these capabilities independently and sovereignly. Following the flight demonstration, the next step will be to further develop the individual luWES components.

    luWES will form a “system of systems” consisting of complementary and modular subsystems that provide electromagnetic protection from the air for armed forces. The stand-off jammer operates from a great distance and enables enemy radar and communications systems to be jammed outside their direct range. This not only protects friendly forces, but also increases their effectiveness, as enemy sensors are suppressed before their area of operation is entered.

    The escort jammer operates alongside manned mission platforms. It actively protects them in enemy territory by continuously jamming enemy radar and missile systems. The stand-in jammer penetrates directly into the enemy’s effective range. It suppresses enemy air defense systems at close range, protecting friendly weapons and thus increasing their effectiveness and assertiveness.

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  • Thales Alenia Space to develop SOLiS very-high-throughput laser communications demonstrator

    Cannes, June 30th, 2025 – Thales Alenia Space, the joint venture between Thales (67%) and Leonardo (33%), has been selected by the French space agency CNES, as part of the space component of the France 2030 program launched by the French government, to develop a very-high-throughput laser communications demonstrator.

    Called SOLiS — for Service Optique de Liaisons Spatiales Sécurisées (secure optical space link service) — this project aims to demonstrate the technical and economic viability of an optical communications service relying on geostationary satellites.

    SOLiS © Thales Alenia Space/ E.Briot

    Such a service is designed to make intercontinental networks more resilient at a time when there is a growing number of acts of sabotage targeting land and undersea optical fiber links. Geostationary satellites offer an effective and cost-effective solution for ultra-secure transfers of large amounts of data between two users on Earth, delivering very high data rates of up to one terabit per second despite distances and atmospheric disturbances.

    SOLiS harnesses technologies developed through the government-backed Optical Communications (CO-OP) project led by CNES and a group of 17 SMEs and large primes, and draws on the outcomes of demonstrations delivered for the VERTIGO project funded by the European Commission.

    Thales Alenia Space will lead the SOLiS project consortium, composed of large industry primes and mid-tier firms (Safran Data Systems, Bertin Technologies, Exail, Keopsys), SMEs (Cedrat Technologies), startups (OGS Technologies, Reuniwatt), and a research center (ONERA), most of which have already worked on the CO-OP project.

    SOLiS plans to develop an optical communications payload and a pilot ground station designed to demonstrate very-high-throughput laser communications. In accordance with a memorandum of understanding between Thales Alenia Space and operator Hellas Sat signed in 2024, this payload will be flown on the Hellas Sat 5 geostationary communications satellite, while the pilot ground station will be set up at the operator’s teleport in Cyprus. This station will communicate with CNES’s FROGS station already operating at the Côte d’Azur Observatory on the Mediterranean coast.

    Building on the accomplishments of the CO-OP project, SOLiS will put French manufacturers — large primes, mid-tier firms, SMEs, and startups — at the forefront in space communications for the 2030s as they strive to address the challenges of security, resilience, fast data rates, and multi-orbit interoperability (between the ground, constellations, and geostationary satellites).

    “We are delighted to be starting development of the payload for the optical communications system, marking a crucial step toward establishing a secure, very-high-throughput optical network,” said Alcino De Sousa, Executive VP, Telecommunications at Thales Alenia Space. “Satellite laser communications projects like SOLiS are set to usher in a new era in telecommunications services, driving development of multi-orbit communications networks.”
     

    About free-space optics

    Free-space optics (FSO) is fast becoming the standard for data transmission in space, offering far superior transmission speeds on the order of one terabit per second compared to a few tens of gigabits per second with current satellite communications systems. This technology is expected to revolutionize space communications infrastructures, in the same way that optical fiber has transformed communications here on Earth.

    The European Commission’s VERTIGO project, and CNES’s CO-OP, DYSCO (Démonstration et sYstème SatCom Optique), and now SOLiS projects are focused on research and development, seeking to demonstrate very-high-data-rate space optical links transmitting through the atmosphere to connect a multitude of users via multiple orbits, ground facilities, and applications.

    These developments show that optical communications technology is a good fit for a range of end-to-end applications, including universal Internet access, direct and permanent data transmission from Earth-observation satellites, private links to data centers, and backup for terrestrial optical fiber in the event of a crisis.

    By reducing the number of satellites required, free-space optics will help to make orbital infrastructures more sustainable while curbing space clutter.

    About Thales Alenia Space 

    Drawing on over 40 years of experience and a unique combination of skills, expertise and cultures, Thales Alenia Space delivers cost-effective solutions for telecommunications, navigation, Earth observation, environmental monitoring, exploration, science and orbital infrastructures. Governments and private industry alike count on Thales Alenia Space to design satellite-based systems that provide anytime, anywhere connections and positioning, monitor our planet, enhance management of its resources, and explore our Solar System and beyond. Thales Alenia Space sees space as a new horizon, helping to build a better, more sustainable life on Earth. A joint venture between Thales (67%) and Leonardo (33%), Thales Alenia Space also teams up with Telespazio to form the Space Alliance, which offers a complete range of solutions including services. Thales Alenia Space posted consolidated revenues of €2.23 billion in 2024 and has more than 8,100 employees in 7 countries with 15 sites in Europe.
     

     

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