Category: 3. Business

  • Apnimed to Participate in the 5th Annual Needham Private Biotech and MedTech Company Virtual 1×1 Forum

    Apnimed to Participate in the 5th Annual Needham Private Biotech and MedTech Company Virtual 1×1 Forum

    CAMBRIDGE, Mass., Oct. 9, 2025 /PRNewswire/ — Apnimed, Inc., a pharmaceutical company building the industry-leading portfolio of first-in-class oral drugs that address the root causes of obstructive sleep apnea (OSA) and other sleep-related breathing diseases, today announced that management will be participating in the 5th Annual Needham Private Biotech and MedTech Company Virtual 1×1 Forum taking place October 14-15, 2025.

    Apnimed will be hosting investor meetings virtually on Tuesday, October 14, and Wednesday, October 15.

    About Apnimed
    Apnimed is a privately held, clinical-stage pharmaceutical company based in Cambridge, Massachusetts, dedicated to transforming the treatment landscape for sleep-related breathing diseases. We believe the introduction of simple, once-nightly oral drugs may dramatically expand diagnosis and the reach of treatment for people with OSA. OSA, like other common chronic diseases such as diabetes or hypertension, would benefit from having multiple drugs with differing mechanisms to more fully address the heterogeneity of disease pathophysiology. Apnimed envisions a new era where novel oral therapies simplify intervention, expand the reach of diagnosis and treatment, and help more people get the oxygen and restorative sleep needed to thrive.

    Apnimed is advancing a robust pipeline of oral pharmaceutical product candidates designed to improve oxygenation in individuals living with OSA and other chronic sleep-related breathing diseases. Our lead candidate, AD109, could become the catalyst for a new oral treatment paradigm for OSA that has been historically limited to cumbersome devices or invasive surgeries. Apnimed is also developing several therapies as part of its joint venture with Shionogi & Co., Ltd., Shionogi-Apnimed Sleep Science.

    Learn more at apnimed.com or follow us on X and LinkedIn.

    Media Contact:
    [email protected]

    Investor Contact:
    [email protected]

    SOURCE Apnimed, Inc.

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  • MEDIA ADVISORY: Stellantis to Announce Third Quarter 2025 Shipments and Revenues on October 30

    MEDIA ADVISORY: Stellantis to Announce Third Quarter 2025 Shipments and Revenues on October 30

    AMSTERDAM – Stellantis N.V. announced today that its Third Quarter 2025 Shipments and Revenues will be released on Thursday, October 30, 2025.

    A live webcast and conference call for the Third Quarter Shipments and Revenues will begin at 1:00 p.m. CET / 8:00 a.m. EDT on Thursday, October 30, 2025.

    The related press release and presentation materials are expected to be posted under the Investors section of the Stellantis corporate website at approximately 8 a.m. CET / 3 a.m. EDT on Thursday, October 30, 2025.

    Details for accessing this presentation are available under the Investors section of the Stellantis corporate website. For those unable to participate in the live session, a recorded replay will be accessible following the event.

     

     

    About Stellantis

    Stellantis N.V. (NYSE: STLA / Euronext Milan: STLAM / Euronext Paris: STLAP) is a leading global automaker, dedicated to giving its customers the freedom to choose the way they move, embracing the latest technologies and creating value for all its stakeholders. Its unique portfolio of iconic and innovative brands includes Abarth, Alfa Romeo, Chrysler, Citroën, Dodge, DS Automobiles, FIAT, Jeep®, Lancia, Maserati, Opel, Peugeot, Ram, Vauxhall, Free2move and Leasys. For more information, visit www.stellantis.com.

     

     


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  • Tietoevry signs strategic multi-country agreement with Entercard

    Tietoevry signs strategic multi-country agreement with Entercard

    Tietoevry Industry has further deepened its Nordic collaboration by entering into a new multi-country agreement with Entercard, one of the region’s foremost credit card providers.

    Owned by Swedbank, Entercard has selected Tietoevry Industry to support its continued digital transformation across Norway, Sweden, Danmark and Finland. The five-year agreement (4+1), valued at approximately EUR 15–17 million, encompasses the delivery of Tietoevry’s advanced Multichannel services, alongside smart complementary solutions designed to accelerate Entercard’s digitalisation journey  

    “We are pleased to extend our partnership with Tietoevry. Having a trusted partner that can support us across Norway, Sweden, Finland, and beyond makes it easier for us to streamline operations and provide a consistent, high-quality experience to our customers throughout the Nordics. We look forward to continuing our collaboration and jointly developing services that meet both current and future needs,” said Geir Broum, Chief Information Officer, Entercard.  

    Smart communication and invoice distribution 

    Tietoevry Industry’s Multichannel platform is a robust document processing solution that enables efficient, flexible customer communication. It ensures that invoices, documents, and messages are delivered via the customer’s preferred channel – whether digital or physical – by integrating with digital mailboxes, payment services, and print providers. This empowers Entercard to optimise communication flows, reduce operational costs, and enhance customer experience. 

    This agreement reinforces Tietoevry’s position as a trusted digital partner within the Nordic financial services sector, delivering value-added solutions that drive both digital innovation and cost efficiency. 

    “We are proud to continue our long-standing partnership with Entercard. This agreement underscores our commitment to supporting their operations across the Nordics with reliable, forward-looking digital solutions. By working closely together, we help Entercard optimise communication and invoice processes while ensuring services are tailored to local markets and future-ready,” said Johan Enger Nygaard, Managing Director, Tietoevry Industry. 

    For more information, please contact 

    Tietoevry Newsdesk, news@tietoevry.com, tel. +358 40 570 4072 

    Tietoevry is a leading software and digital engineering services company with global market reach and capabilities. We provide customers across different industries with mission-critical solutions through our specialized software businesses Tietoevry Care, Tietoevry Banking and Tietoevry Industry, as well as our digital engineering business Tietoevry Create. Our around 15 000 talented vertical software, design, cloud and AI experts are dedicated to empowering our customers to succeed and innovate with latest technology. Tietoevry’s annual revenue is approximately EUR 2 billion. The company’s shares are listed on the NASDAQ exchange in Helsinki and Stockholm, as well as on Oslo Børs. www.tietoevry.com

     

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  • Absolute Emissions from the Permian Basin Declined Nearly 20% Since 2022, Even as Oil and Gas Production Grew, New S&P Global Commodity Insights Analysis Finds

    Absolute Emissions from the Permian Basin Declined Nearly 20% Since 2022, Even as Oil and Gas Production Grew, New S&P Global Commodity Insights Analysis Finds

    HOUSTON, Oct. 9, 2025 /PRNewswire/ — Absolute greenhouse gas emissions from the Permian basin—one of the most prolific oil and gas fields in the world, responsible for 40% of total production in the United States—declined every year since 2022, even as production of oil and gas increased, according to a new analysis by S&P Global Commodity Insights.

    S&P Global Inc. logo

    Absolute greenhouse gas (GHG) emissions from the Permian declined by 25 million metric tons of carbon dioxide equivalent (MMt CO2e) during the years 2022-2024, a 20% reduction during a period when oil and gas production increased by the equivalent of 500,000 barrels per day.

    Although the GHG intensity of oil and gas activity—the ratio of emissions per barrel produced—in the basin has consistently declined over the past several years, the reduction in absolute emissions during a period of production growth was a surprise, the analysis says.

    “This is a whole new ballgame,” said Kevin Birn, Head of the Center for Emissions Excellence, S&P Global Commodity Insights. “Major Permian producers have a long track record of improvements from an emissions per barrel standpoint, but at the end of the day more barrels produced typically means more emissions. However, over the past few years in the Permian, more barrels came with lower emissions. It’s a have-your-cake-and-eat-it-too moment.”

    The biggest factor in the overall emissions reduction has been the improved detection and mitigation of methane, the analysis says. A more potent greenhouse gas, methane emissions account for approximately two-thirds of total emissions in the Permian.

    Improved operations, better equipment and the utilization of artificial intelligence and other advanced technologies reduced the methane intensity of Permian production by more than 50% during the 2022-2024 period, according to a previous S&P Global Commodity Insights analysis for Permian upstream methane. The scale of methane reduction outpaced the impact of production growth leading to absolute emissions declining.

    “The introduction of higher quality observational data in recent years not only establishes a more credible baseline against which to measure emissions mitigation, it enables technologies and practices that allow producers to improve those efforts, or to even anticipate and prevent emissions altogether,” said Raoul LeBlanc, Vice President, Global Upstream, S&P Global Commodity Insights. “Data show methane emissions management is being increasingly normalized as part of field operations and that is driving methane down.”

    The new analysis—which includes methane and carbon dioxide emissions to provide a more complete assessment of the GHG emissions for the Permian—finds that the basin produced nearly 11 million barrels of oil at an average GHG intensity of 22 kilograms of carbon dioxide equivalent per barrel of oil equivalent produced (equivalent to 3.8gCO2e/MJ) in 2024.

    However, intensity varied widely from one well to another, ranging from more than 160 kgCO2e/boe (28 gCO2e/MJ) to less than 4 kgCO2e/boe (0.69 gCO2e/MJ), reflecting the dynamic nature of production in the basin.

    “The variation of intensity from one well to the next underscores the myriad factors that can impact the GHG intensity of any one asset and that an overreliance on basin-wide averages can be extremely limiting,” said Shane Whipple, Emissions Insight Analyst, Center of Emissions Excellence. “Utilizing S&P Global Commodity Insights’ unique capabilities, we are able to provide a level of granularity to truly understand the nature of upstream oil and gas emissions for each individual asset.”

    About the analysis

    The S&P Global Commodity Insight’s estimate of Permian emissions includes carbon dioxide, nitrous oxide and methane emissions of upstream oil and gas operations. Coverage includes all drilling and completions (including natural gas and diesel combustion), operations, electricity imports and flaring and fugitives across the three main Permian plays: Wolfcamp Midland, Wolfcamp Delaware and Bone Springs. Midstream transportation emissions are not included.

    Upstream emissions estimates make use of a complex, purpose-built bottom-up model built atop of S&P Global Commodity Insights extensive upstream database and coverage of all active wells in the Permian on a monthly basis over the entire time period presented in this study. This model is independent of U.S. Environmental Protection Agency reporting although is regularly compared against it and other public sources.

    Beginning in 2022, S&P Global Commodity Insights estimates made use of methane observation data from Insight M. These data greatly increased both the volume of methane emissions and the reliability of those estimates. Estimates prior to 2022 used sophisticated calculations and factors to estimate venting and fugitive methane emissions but were notably lower quality. More information on the methane observation data used from Insight M is available here: https://view.highspot.com/viewer/651121fb7c2bcb2c1c1b9fb0f6868d3f#1  

    Coverage of upstream activity is comprehensive. In 2024, coverage included all 160,000 active wells and 12,000 new wells in the Wolfcamp Midland, Wolfcamp Delaware and Bone Springs—100% of producing wells. Methane observations from Insight M for the same period included 81.8% of the 160,000 active Permian wells, (78.5% of conventional wells and 88.6% of unconventional wells). These assets supplied 90.0% of the 3.9 billion boe produced in 2024.

    Insight M overflights observation data provides a level of resolution that is up to 5 times greater than that of satellites, providing reliable attribution not only by facility, but in most cases to specific assets or pieces of equipment.

    Threshold for detection isn’t a factor for methane estimates prior to 2022 due to the methodology model estimates. Insight M methane observations since 2022, are as low as the range of 50-10 kg/hr depending on the specific overflight. These observed volumes account for more than 68% of total methane released to the atmosphere from upstream oil and gas operations. The volumes from all sources below this threshold were estimated using the Rutherford model developed by Stanford University and included in the totals used in the analysis. More information on the methodology employed by Insight M can be found here: https://view.highspot.com/viewer/992ecc322aa7c4d80d5f6b15a4a0f2c4#1 

    Global Warming Potential Factor:

    S&P Global Commodity Insights conversion of methane to CO2 equivalency are based on a Global Warming Potential (GWP) factor for 100 years of 28 tons of CO2 per ton of methane. Using the 20-year factor of 86 would thus increase both the emissions reduction and the continuing emissions to 3.07 times the figures cited in this report.

    Media Contacts:

    Jeff Marn +1-202-463-8213, Jeff.marn@spglobal.com 

    Americas: Kathleen Tanzy + 1 917-331-4607, kathleen.tanzy@spglobal.com
    Asia: Melissa Tan + 65-6597-6241, melissa.tan@spglobal.com

    About S&P Global Commodity Insights
    At S&P Global Commodity Insights, our complete view of global energy and commodity markets enables our customers to make decisions with conviction and create long-term, sustainable value. 

    We’re a trusted connector that brings together thought leaders, market participants, governments, and regulators and we create solutions that lead to progress. Vital to navigating commodity markets, our coverage includes oil and gas, power, chemicals, metals, agriculture, shipping and energy transition. Platts® products and services, including leading benchmark price assessments in the physical commodity markets, are offered through S&P Global Commodity Insights. S&P Global Commodity Insights maintains clear structural and operational separation between its price assessment activities and the other activities carried out by S&P Global Commodity Insights and the other business divisions of S&P Global. 

    S&P Global Commodity Insights is a division of S&P Global (NYSE: SPGI). S&P Global is the world’s foremost provider of credit ratings, benchmarks, analytics and workflow solutions in the global capital, commodity and automotive markets. With every one of our offerings, we help many of the world’s leading organizations navigate the economic landscape so they can plan for tomorrow, today. For more information visit https://www.spglobal.com/commodityinsights.

    SOURCE S&P Global Commodity Insights

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  • IonQ Achieves Top 10 Ranking in Prestigious Fortune Future 50 List of Global Enterprise Companies

    IonQ Achieves Top 10 Ranking in Prestigious Fortune Future 50 List of Global Enterprise Companies

    College Park, MD — October 9, 2025

    • IonQ is the only quantum company in the world to be included on distinguished list
    • Recognition highlights confidence in IonQ’s ability to grow in dynamic markets and deliver long-term value

    COLLEGE PARK, MD – October 9, 2025 – IonQ (NYSE: IONQ), the world’s leading quantum company, today announced that it has been awarded a top 10 ranking on the Fortune 2025 Future 50 list. This list recognizes companies from around the world that have superior long-term growth potential based on their strategy, technology, workforce, organizational setup, and culture. IonQ ranked eighth on this year’s list – the only quantum company in the world to be included – joining a select group of global innovators recognized for their high growth and projected long-term value.

    The Boston Consulting Group and Fortune evaluated more than 2,800 publicly traded companies with at least $5 billion in market cap and analyzed 10 million data points to identify and rank the companies on the list. IonQ’s inclusion in the top 10 places it alongside Snowflake and ahead of globally recognized tech innovators such as OpenAI, Palantir, CrowdStrike, Docusign, Shopify, and others. 

    “Being named to the Fortune Future 50 is a testament to the hard work of our team and the confidence of our partners, investors, and customers,” said Niccolo de Masi, Chairman and CEO at IonQ. “As the leading quantum company, we’re thrilled to be named alongside many of the fastest-growing technology companies in the world. This recognition reinforces our mission to provide quantum computing, networking, and sensing solutions to fundamentally reshape how the world solves complex problems.”

    This recognition comes amid continued advancements in IonQ’s technological roadmap, global partnerships, and company growth. The company recently announced it achieved a record algorithmic qubit score of #AQ 64, which significantly outperformed IBM and competing quantum systems in multiple commercially relevant algorithms. IonQ has also significantly strengthened its patent portfolio over the last year, with its intellectual property portfolio now surpassing 1,000 licensed, owned, or controlled patents and patent applications, all building on the company’s technical achievements. 

    The Fortune Future 50 ranking also follows several other recent accolades for IonQ, including Newsweek’s Excellence Index 1000, Forbes’ list of Most Successful Mid-Cap Companies, and Built-In’s Best Midsize Places to Work in Washington, DC and Seattle.

    About IonQ
    IonQ, Inc. [NYSE: IONQ] is the world’s leading quantum company delivering solutions to solve the world’s most complex problems. IonQ’s current generation quantum computers, IonQ Forte and IonQ Forte Enterprise, are the latest in a line of cutting-edge systems that have been helping customers and partners such as Amazon Web Services, AstraZeneca, and NVIDIA achieve 20x performance results.

    The company is accelerating its technology roadmap and intends to deliver the world’s most powerful quantum computers with 2 million qubits by 2030 to accelerate innovation in drug discovery, materials science, financial modeling, logistics, cybersecurity, and defense. IonQ’s advancements in quantum networking also position the company as a leader in building the quantum internet.

    The company’s innovative technology and rapid growth were recognized in Newsweek’s 2025 Excellence Index 1000, Forbes’ 2025 Most Successful Mid-Cap Companies list, and Built In’s 2025 100 Best Midsize Places to Work in Washington DC and Seattle, respectively. Available through all major cloud providers, IonQ is making quantum computing more accessible and impactful than ever before. Learn more at IonQ.com.

    IonQ Forward-Looking Statements
    This press release contains certain forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. Some of the forward-looking statements can be identified by the use of forward-looking words. Statements that are not historical in nature are intended to identify forward-looking statements. These statements include those related to the IonQ’s quantum capabilities and plans. Forward-looking statements are predictions, projections, and other statements about future events that are based on current expectations and assumptions and, as a result, are subject to risks and uncertainties. Many factors could cause actual future events to differ materially from the forward-looking statements in this press release, including but not limited to: IonQ’s ability to implement its business plans, forecasts, roadmaps and other expectations, and changes in the competitive industries in which IonQ operates, including development of competing technologies. You should carefully consider the foregoing factors and the other risks and uncertainties disclosed in the Company’s filings, including but not limited to those described in the “Risk Factors” section of IonQ’s most recent periodic financial report (10-Q or 10-K) filed by IonQ with the Securities and Exchange Commission. These filings identify and address other important risks and uncertainties that could cause actual events and results to differ materially from those contained in the forward-looking statements. Forward-looking statements speak only as of the date they are made. Readers are cautioned not to put undue reliance on forward-looking statements, and IonQ assumes no obligation and does not intend to update or revise these forward-looking statements, whether as a result of new information, future events, or otherwise. IonQ does not give any assurance that it will achieve its expectations.

    Contacts

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  • Merck to Present New Data from HIV Treatment and Prevention Pipeline at European AIDS Conference 2025

    October 9, 2025 7:00 am EDT


    Merck (NYSE: MRK), known as MSD outside of the United States and Canada, announced today that it will present new findings from its HIV treatment and prevention pipeline at the 20th European AIDS Conference (EACS 2025) taking place Oct.15-18, 2025, in Paris, France. The company’s presentations will include:

    • An oral presentation of weight and body composition at Week 48 from the Phase 3 trial ( MK-8591A-052) comparing doravirine/islatravir [DOR/ISL (100mg/0.25mg)] vs. bictegravir/emtricitabine/tenofovir alafenamide i[BIC/FTC/TAF (50mg/200mg/25mg)] for the once-daily treatment of adults with virologically suppressed HIV-1 infection on antiretroviral therapy
    • A poster presentation of fasting lipids and insulin resistance at Week 48 from two Phase 3 trials comparing DOR/ISL vs. baseline antiretroviral therapy ( MK-8591A-051) or BIC/FTC/TAF ( MK-8591A-052), for the once-daily treatment of adults with virologically suppressed HIV-1 infection on antiretroviral therapy
    • An oral presentation of 96 weeks of safety and pharmacokinetics data from the Phase 2 trial ( NCT05052996) of the investigational once-weekly oral combination of islatravir in combination with lenacapavir (MK-8591D) for adults with virologically suppressed HIV-1 infection on BIC/FTC/TAF
    • A poster presentation of MK-8527 Phase 1 safety and pharmacokinetics data in adults with moderate or severe renal impairment ( MK-8527-008); MK-8527 is Merck’s investigational once-monthly pill for HIV pre-exposure prophylaxis (PrEP)

    “We are pleased to share new data from across our HIV pipeline at EACS 2025, including additional analyses from the Phase 3 program of the investigational once-daily, two-drug treatment regimen, DOR/ISL, which is currently under review with the U.S. Food and Drug Administration,” said Dr. Luisa Stamm, associate vice president and HIV section head at Merck Research Laboratories. “By advancing multiple investigational agents for daily and weekly treatments and monthly oral prevention, we aim to give individuals new and different ways to treat and prevent HIV.”

    Select abstracts in the EACS 2025 program include:

    Abstract Title and Author

    Date and Time

    HIV TREATMENT

    Weight and Body Composition After Switch to Doravirine/Islatravir (100mg/0.25mg) Once Daily from BIC/FTC/TAF in Adults Living With HIV-1: Week 48 Results from a Randomized, Double-Blind Phase 3 Study. Orkin, C, et al.

    Oral Presentation​

    Thursday, October 16, 2025,​

    11:00 – 12:00

    Evaluation of Fasting Lipids and Insulin Resistance After Switch to Doravirine/Islatravir (100mg/0.25mg) Once Daily: Week 48 Results From Two Randomized Phase 3 Studies in Adults Living With HIV‑1. Calmy, A, et al.

    Moderated ePoster​

    Friday, October 17, 2025,​

    15:35 – 16:10

    Oral Weekly Islatravir Plus Lenacapavir in Virologically Suppressed People with HIV-1: 96 Week Outcomes from a Phase 2 Study. Colson, A, et al.

    Oral Presentation

    Saturday, October 18, 2025

    09:15 – 10:15

    Patient-Reported Outcomes From People With HIV-1 Receiving Once-Weekly Oral Islatravir in Combination With Lenacapavir: Phase 2 Week 48 Results. Eron, J, et al.

    ePoster

    HIV PREVENTION

    Pharmacokinetics and Safety of MK-8527 in Adults With Moderate or Severe Renal Impairment, Carstens, R, et al.

    ePoster

    This year at EACS, Merck will host a policy symposium “Ending the Epidemic in Europe: Policy Challenges and Opportunities” on Thursday, October 16, from 18:00 – 19:30 CEST. Merck will also host a medical symposium “Optimization of HIV Care” on Friday, Oct. 17, from 12:30 – 14:00 CEST. Both events will be open to all registered attendees.

    For more details about Merck’s clinical development program in HIV treatment and prevention, click here.

    Merck’s Commitment to HIV

    For more than 35 years, Merck has been committed to scientific research and discovery in HIV leading to scientific breakthroughs that have helped change HIV treatment. Our work has helped pioneer the development of new options across multiple drug classes to help those impacted by HIV. Today, we are developing a series of antiviral options designed to help people manage their HIV and to help prevent HIV, with the goal of reducing the growing burden of infection worldwide. We want to ensure people are not defined by HIV, and our work focuses on transformational innovations, collaborations with others in the global HIV community, and access initiatives aimed at helping to end the HIV epidemic for everyone.

    Indications and usage for PIFELTRO® (doravirine) and DELSTRIGO® (doravirine, lamivudine, and tenofovir disoproxil fumarate) in the U.S.

    PIFELTRO is indicated in combination with other antiretroviral (ARV) agents for the treatment of HIV-1 infection in adult patients with no prior ARV treatment history or to replace the current ARV regimen in those who are virologically suppressed (HIV-1 RNA less than 50 copies per mL) on a stable ARV regimen with no history of treatment failure and no known substitutions associated with resistance to doravirine.

    DELSTRIGO is indicated as a complete regimen for the treatment of HIV-1 infection in adult patients with no prior ARV treatment history or to replace the current ARV regimen in those who are virologically suppressed (HIV-1 RNA less than 50 copies per mL) on a stable ARV regimen with no history of treatment failure and no known substitutions associated with resistance to the individual components of DELSTRIGO.

    Selected Safety Information

    Warning: Posttreatment Acute Exacerbation of Hepatitis B Virus (HBV) for DELSTRIGO

    All patients with HIV-1 should be tested for the presence of HBV before initiating ARV therapy. Severe acute exacerbations of HBV have been reported in people with concomitant HIV-1 and HBV who have discontinued products containing lamivudine or tenofovir disoproxil fumarate (TDF), which are components of DELSTRIGO. Patients coinfected with HIV-1 and HBV who discontinue DELSTRIGO should be monitored with both clinical and laboratory follow-up for at least several months after stopping DELSTRIGO. If appropriate, initiation of anti-HBV therapy may be warranted.

    Contraindications

    PIFELTRO and DELSTRIGO are contraindicated when coadministered with drugs that are strong cytochrome P450 (CYP)3A enzyme inducers (including the anticonvulsants carbamazepine, oxcarbazepine, phenobarbital, and phenytoin; the androgen receptor inhibitor enzalutamide; the antimycobacterials rifampin and rifapentine; the cytotoxic agent mitotane; and the herbal product St. John’s wort (Hypericum perforatum)), as significant decreases in doravirine plasma concentrations may occur, which may decrease the effectiveness of DELSTRIGO and PIFELTRO.

    DELSTRIGO is contraindicated in patients with a previous hypersensitivity reaction to lamivudine.

    Warnings and Precautions

    Severe Skin Reactions

    Severe skin reactions, including Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN), have been reported during the postmarketing experience with doravirine-containing regimens. Discontinue PIFELTRO or DELSTRIGO, and other medications known to be associated with severe skin reactions, immediately if a painful rash with mucosal involvement or a progressive severe rash develops. Clinical status should be closely monitored, and appropriate therapy should be initiated.

    New or Worsening Renal Impairment

    Renal impairment, including cases of acute renal failure and Fanconi syndrome, have been reported with the use of TDF. DELSTRIGO should be avoided with concurrent or recent use of a nephrotoxic agent (e.g., high-dose or multiple NSAIDs). Cases of acute renal failure after initiation of high-dose or multiple NSAIDs have been reported in people living with HIV with risk factors for renal dysfunction who appeared stable on TDF.

    Prior to or when initiating DELSTRIGO, and during treatment, assess serum creatinine, estimated creatinine clearance, urine glucose, and urine protein in all patients. In patients with chronic kidney disease, also assess serum phosphorus. Discontinue DELSTRIGO in patients who develop clinically significant decreases in renal function or evidence of Fanconi syndrome. Discontinue DELSTRIGO if estimated creatinine clearance declines below 50 mL/min.

    Bone Loss and Mineralization Defects

    In clinical trials in adults living with HIV, TDF was associated with slightly greater decreases in bone mineral density (BMD) and increases in biochemical markers of bone metabolism. Serum parathyroid hormone levels and 1,25 Vitamin D levels were also higher. Cases of osteomalacia associated with proximal renal tubulopathy have been reported with the use of TDF. The effects of TDF-associated changes in BMD and biochemical markers on long-term bone health and future fracture risk in adults are unknown.

    Immune Reconstitution Syndrome

    Immune reconstitution syndrome can occur, including the occurrence of autoimmune disorders with variable time to onset, which may necessitate further evaluation and treatment.

    Drug Interactions

    Because DELSTRIGO is a complete regimen, coadministration with other antiretroviral medications for the treatment of HIV-1 infection is not recommended.

    Coadministration of PIFELTRO with efavirenz, etravirine, or nevirapine is not recommended.

    If DELSTRIGO is coadministered with rifabutin, take one tablet of DELSTRIGO once daily, followed by one tablet of doravirine (PIFELTRO) approximately 12 hours after the dose of DELSTRIGO.

    If PIFELTRO is coadministered with rifabutin, increase PIFELTRO dosage to one tablet twice daily (approximately 12 hours apart).

    Consult the full Prescribing Information prior to and during treatment for more information on potential drug-drug interactions.

    Dosage and Administration/Specific Populations

    Renal Impairment

    Because DELSTRIGO is a fixed-dose combination tablet and the dosage of lamivudine and TDF cannot be adjusted, DELSTRIGO is not recommended in patients with estimated creatinine clearance less than 50 mL/min.

    Adverse Reactions

    The most common adverse reactions with DELSTRIGO (incidence ≥5%, all intensities) were dizziness (7%), nausea (5%), and abnormal dreams (5%). The most common adverse reactions with PIFELTRO (incidence ≥5%, all intensities) were nausea (7%), dizziness (7%), headache (6%), fatigue (6%), diarrhea (6%), abdominal pain (5%), and abnormal dreams (5%).

    By week 96 in DRIVE-FORWARD, 2% of adult participants in the PIFELTRO group and 3% in the darunavir+ritonavir (DRV+r) group had adverse events leading to discontinuation of study medication.

    By week 96 in DRIVE-AHEAD, 3% of adult participants in the DELSTRIGO group and 7% in the efavirenz (EFV)/emtricitabine (FTC)/TDF group had adverse events leading to discontinuation of study medication.

    In DRIVE-FORWARD, mean changes from baseline at week 48 in LDL-cholesterol (LDL-C) and non-HDL-cholesterol (non-HDL-C) were pre-specified. LDL-C: -4.6 mg/dL in the PIFELTRO group vs 9.5 mg/dL in the DRV+r group. Non-HDL-C: -5.4 mg/dL in the PIFELTRO group vs 13.7 mg/dL in the DRV+r group. The clinical benefits of these findings have not been demonstrated.

    In DRIVE-AHEAD, mean changes from baseline at week 48 in LDL-C and non-HDL-C were pre-specified. LDL-C: -2.1 mg/dL in the DELSTRIGO group vs 8.3 mg/dL in the EFV/FTC/TDF group. Non-HDL-C: -4.1 mg/dL in the DELSTRIGO group vs 12.7 mg/dL in the EFV/FTC/TDF group. The clinical benefits of these findings have not been demonstrated.

    In DRIVE-SHIFT, mean changes from baseline at week 24 in LDL-C and non-HDL-C were pre-specified. LDL-C: -16.3 mg/dL in the DELSTRIGO group vs -2.6 mg/dL in the PI + ritonavir group. Non-HDL-C: -24.8 mg/dL in the DELSTRIGO group vs -2.1 mg/dL in the PI + ritonavir group. The clinical benefits of these findings have not been demonstrated.

    In DRIVE-AHEAD, neuropsychiatric adverse events were reported in the three pre-specified categories of sleep disorders and disturbances, dizziness, and altered sensorium. Twelve percent of adult participants in the DELSTRIGO group and 26% in the EFV/FTC/TDF group reported neuropsychiatric adverse events of sleep disorders and disturbances; 9% in the DELSTRIGO group and 37% in the EFV/FTC/TDF group reported dizziness; and 4% in the DELSTRIGO group and 8% in the EFV/FTC/TDF group reported altered sensorium.

    The safety of DELSTRIGO in virologically-suppressed adults was based on week 48 data from participants in the DRIVE-SHIFT trial. Overall, the safety profile in virologically-suppressed adult participants was similar to that in participants with no ARV treatment history.

    Serum ALT and AST Elevations: In the DRIVE-SHIFT trial, 22% and 16% of participants in the immediate switch group experienced ALT and AST elevations greater than 1.25 X ULN, respectively, through 48 weeks on DELSTRIGO. For these ALT and AST elevations, no apparent patterns with regard to time to onset relative to switch were observed. One percent of participants had ALT or AST elevations greater than 5 X ULN through 48 weeks on DELSTRIGO. The ALT and AST elevations were generally asymptomatic, and not associated with bilirubin elevations. In comparison, 4% and 4% of participants in the delayed switch group experienced ALT and AST elevations of greater than 1.25 X ULN through 24 weeks on their baseline regimen.

    Pregnancy/Breastfeeding

    There is a pregnancy exposure registry that monitors pregnancy outcomes in individuals exposed to PIFELTRO or DELSTRIGO during pregnancy. Healthcare providers are encouraged to register patients by calling the Antiretroviral Pregnancy Registry (APR) at 1-800-258-4263.

    Inform individuals with HIV-1 infection of the potential risks of breastfeeding, including: (1) HIV-1 transmission (in HIV-1–negative infants), (2) developing viral resistance (in HIV-1–positive infants), and (3) serious adverse reactions in a breastfed infant similar to those seen in adults.

    About Merck

    At Merck, known as MSD outside of the United States and Canada, we are unified around our purpose: We use the power of leading-edge science to save and improve lives around the world. For more than 130 years, we have brought hope to humanity through the development of important medicines and vaccines. We aspire to be the premier research-intensive biopharmaceutical company in the world – and today, we are at the forefront of research to deliver innovative health solutions that advance the prevention and treatment of diseases in people and animals. We foster a diverse and inclusive global workforce and operate responsibly every day to enable a safe, sustainable and healthy future for all people and communities. For more information, visit www.merck.com and connect with us on X (formerly Twitter), Facebook, Instagram, YouTube and LinkedIn.

    Forward-Looking Statement of Merck & Co., Inc., Rahway, N.J., USA

    This news release of Merck & Co., Inc., Rahway, N.J., USA (the “company”) includes “forward-looking statements” within the meaning of the safe harbor provisions of the U.S. Private Securities Litigation Reform Act of 1995. These statements are based upon the current beliefs and expectations of the company’s management and are subject to significant risks and uncertainties. There can be no guarantees with respect to pipeline candidates that the candidates will receive the necessary regulatory approvals or that they will prove to be commercially successful. If underlying assumptions prove inaccurate or risks or uncertainties materialize, actual results may differ materially from those set forth in the forward-looking statements.

    Risks and uncertainties include but are not limited to, general industry conditions and competition; general economic factors, including interest rate and currency exchange rate fluctuations; the impact of pharmaceutical industry regulation and health care legislation in the United States and internationally; global trends toward health care cost containment; technological advances, new products and patents attained by competitors; challenges inherent in new product development, including obtaining regulatory approval; the company’s ability to accurately predict future market conditions; manufacturing difficulties or delays; financial instability of international economies and sovereign risk; dependence on the effectiveness of the company’s patents and other protections for innovative products; and the exposure to litigation, including patent litigation, and/or regulatory actions.

    The company undertakes no obligation to publicly update any forward-looking statement, whether as a result of new information, future events or otherwise. Additional factors that could cause results to differ materially from those described in the forward-looking statements can be found in the company’s Annual Report on Form 10-K for the year ended December 31, 2024 and the company’s other filings with the Securities and Exchange Commission (SEC) available at the SEC’s Internet site (www.sec.gov).

    Please see Prescribing Information for PIFELTRO (doravirine) at: https://www.merck.com/product/usa/pi_circulars/p/pifeltro/pifeltro_pi.pdf and Patient Information for PIFELTRO at: https://www.merck.com/product/usa/pi_circulars/p/pifeltro/pifeltro_ppi.pdf

    Please see Prescribing Information for DELSTRIGO (doravirine, lamivudine, and tenofovir disoproxil fumarate) at: https://www.merck.com/product/usa/pi_circulars/d/delstrigo/delstrigo_pi.pdf and Patient Information for DELSTRIGO at: https://www.merck.com/product/usa/pi_circulars/d/delstrigo/delstrigo_ppi.pdf

    i bictegravir/emtricitabine/tenofovir alafenamide (BIKTARVY) is a registered trademark of Gilead Sciences, Inc.


    Source: Merck & Co., Inc.


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  • Securing Africa’s Energy Future: Building Robust Energy Security Data Systems – Event

    Securing Africa’s Energy Future: Building Robust Energy Security Data Systems – Event

    Africa’s energy security is increasingly shaped by volatile global fuel markets, climate extremes, infrastructure constraints, and rapid electrification. Timely, interoperable, and trustworthy data are the backbone of effective responses, supporting early‐warning signals, contingency planning, affordability measures, and resilient investment. Yet, across many African Member States, energy security data remain fragmented across institutions, captured with heterogeneous definitions, and disseminated with time lags that blunt policy impact.

    African Energy Commission (AFREC) and the International Energy Agency (IEA) propose a joint webinar to facilitate a dialogue on how African countries can strengthen energy security data systems. The session will showcase data collection tools and templates aligned with International Standards (IRES/SIEC) and examples of short‑term energy security indicators that can be developed for the region. The webinar will be an opportunity to identify priority areas for capacity development activities among Member States.

    Webinar objectives

    • Highlight the importance of energy security data among stakeholders in Africa.

    • Explain how African Member States can strengthen their energy security data systems and transform the data into useful indicators for policy development.

    • Showcase the progress of specific African countries in collecting and using energy security data, including lessons learned.

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  • Public consultation on joint guidelines on the interplay between DMA and GDPR

    Public consultation on joint guidelines on the interplay between DMA and GDPR

    The European Commission and the European Data Protection Board (EDPB) have launched a public consultation to gather feedback on draft guidelines on the interplay between the Digital Markets Act (DMA) and the General Data Protection Regulation (GDPR). 

    The guidelines will aid companies to interpret and comply with the two sets of rules and the points in which they intersect. This includes provisions in the DMA on the combination and portability of users’ data, which involve processing personal data and therefore require compliance with GDPR. Also, the DMA foresees alternative app stores and distribution channels for apps, for which gatekeepers may put in place strictly necessary and proportionate measures that must also comply with GDPR.

    This collaboration, which started in September 2024, aims to improve legal clarity and certainty for businesses in the EU, while ensuring the effectiveness of both sets of rules. The two sets of rules will be applied coherently, in full respect of the distinct competences of each body. 

    Interested parties have until 4 December 2025 to submit their input. 

    Following the assessment of the feedback collected, the final Guidelines will be adopted in 2026. 

    After the closing of the consultation, all submissions will be published on the DMA website to which a link will be included on the EDPB website.

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  • Scientists urged to demand independent governance in Horizon Europe

    The chair of an expert group charged with advising the European Commission on the next Framework Programme for research and innovation has called for a campaign of “scientific activism” to implement independent governance models across the programme.

    The European Research Council (ERC) is “the jewel of the crown” of EU research funding thanks to its independent Scientific Council, which draws up its own work programmes, Manuel Heitor said during a panel on competitiveness through frontier research organised by the ERC and the University of Copenhagen on October 7.

    The former Portuguese research minister was more critical of the collaborative instruments in Horizon Europe and its predecessor, Horizon 2020. The Framework Programme “has become an excellent tool to distribute money, but it is not necessarily the best tool to do science, or to address industrial competitiveness, or to address emerging societal challenges,” he said.

    According to his advisory group’s report, collaborative projects accounted for 78% of funding under Horizon 2020 and involved 11 participants on average, each receiving average funding of €127,000 over approximately three years. The remaining 22% of funds, which mostly support single beneficiaries, have had a greater impact, largely thanks to the ERC’s autonomy, Heitor said.

    He urged the scientific community to speak to citizens and national and EU policymakers to show that the ERC is a “clear example of how to govern the rest of the Framework Programme.”

    His report recommended strengthening the independence of the European Innovation Council and creating two new councils with independent boards, one on industrial competitiveness and technology, and the other on societal challenges, to steer collaborative research. However, this idea was not picked up by the Commission in its proposal for the post-2027 Horizon Europe programme.

    Instead, there are concerns that collaborative research and innovation will come under even closer control by the Commission, which plans to link calls to the funding priorities of the future European Competitiveness Fund.

    It’s also unclear what the push to simplify the EU funding landscape will mean for the ERC. Its president, Maria Leptin, previously expressed concern that plans for a single rulebook to be applied across Horizon Europe and the Competitiveness Fund would restrict the ERC’s flexibility to implement its own processes. However, in a recent interview with Science|Business, Leptin revealed that the ERC had received reassurance from the Commission that it would not fall under a common rulebook.

    In June, before the Commission presented its proposal for the continuation of Horizon Europe, the ERC’s Scientific Council sent a letter to its president, Ursula von der Leyen, and research Commissioner Ekaterina Zaharieva requesting even greater independence and a stable, long-term budget.

    Protecting fundamental research

    During the Copenhagen conference, Denmark’s science minister, Christina Egelund, underlined the importance of “bold investments in innovation,” starting with fundamental research. The Danish presidency “will make sure to bring [Horizon Europe] negotiations forward and not to lose sight of frontier research,” she said.

    This is reflected in the Commission’s proposal for the next Horizon Europe programme, which foresees a significant budget increase for the ERC.


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    The ERC is also at the centre of the EU’s efforts to lure disaffected scientists from the US, but speaking at the conference Leptin insisted there will be no winners from the US government’s budget cuts and assaults on academic freedom.

    “We’re all going to suffer,” she said, pointing to US cuts to climate data stations and model organism databases. “We attract these scientists over, and then we say, sorry, no databases [. . .] There is no benefit to be gained.”

    Until the US situation improves, Europe should offer scientists a “haven,” in a “non-selfish manner,” Leptin said. “If they come and spend half time here, that’s enough, that reinforces collaboration.”

    Lottery funding

    The following day, Copenhagen hosted a life science summit under the Danish presidency of the EU Council, where competitiveness was once again on the agenda.

    Europe needs more fundamental research, but it also needs bold ideas to make public funding more efficient, said Margrethe Vestager, former commissioner for competition and now chair of the board of the Technical University of Denmark.

    “There are so many great ideas for the public funding, and I think it feels like a lottery as to whether you get it or not, so why not make it a lottery?” she said. “Then, if you don’t get funding that year, you can get more points, so you have a better chance the next year.”

    The objective should be to reduce the time and resources required to obtain funding, she added. 

    The Commission has made simplification a priority, and Zaharieva has said it is “exploring” the idea of introducing lottery funding in the next iteration of Horizon Europe.

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  • PepsiCo (PEP) Q3 2025 earnings

    PepsiCo (PEP) Q3 2025 earnings

    FILE PHOTO: Cans of Pepsi are seen at the PepsiCo Walkers factory in Leicester, Britain, August 14, 2024. 

    Hollie Adams | Reuters

    PepsiCo on Thursday reported quarterly earnings and revenue that beat analysts’ expectations, as international growth offset another quarter of declining volume in North America.

    Here’s what the company reported for its fiscal third quarter compared with what Wall Street was expecting, based on a survey of analysts by LSEG:

    • Earnings per share: $2.29 adjusted vs. $2.26 expected
    • Revenue: $23.94 billion vs. $23.83 billion expected

    Pepsi reported third-quarter net income attributable to the company of $2.6 billion, or $1.90 per share, down from $2.93 billion, or $2.13 per share, a year earlier.

    Excluding items, the company earned $2.29 per share.

    Net sales rose 2.6% to $23.94 billion. Stripping out acquisitions, divestitures and foreign exchange, Pepsi’s organic revenue increased 1.3% in the quarter.

    However, the Frito-Lay and Gatorade owner is still seeing softer demand for its products. Pepsi’s worldwide volume for both food and drinks fell 1% during the quarter. The metric strips out pricing and foreign exchange changes.

    In particular, Pepsi has struggled in its home market in recent quarters, leading the company to invest back into its brands and to explore cost-cutting measures.

    Pepsi Foods North America, which includes brands like Doritos, Quaker Oats and Pearl Milling, reported that its volume fell 4% in the fiscal third quarter. And Pepsi’s North American beverage unit saw volume shrink 3%, although CEO Ramon Laguarta noted “improved momentum” in the business.

    The company also reiterated its full-year outlook. It still expects its core constant currency earnings per share to be roughly unchanged from the prior year and organic revenue to grow by a low single-digit percentage.

    Pepsi also announced on Thursday that Chief Financial Officer Jamie Caulfield plans to retire. Walmart U.S. CFO Steve Schmitt will succeed him, effective Nov. 10.

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