Category: 3. Business

  • Pakistani rupee posts biggest weekly gain in 93 weeks amid improved dollar supplies

    Pakistani rupee posts biggest weekly gain in 93 weeks amid improved dollar supplies

    The Pakistani rupee surged on Friday, marking its largest weekly gain in 93 weeks, driven by improved dollar supplies, a crackdown on black market currency trade, and a shift in the central bank’s strategy for building forex reserves. 

    The currency rose 0.27% to 283.45 against the dollar, with a 0.5% weekly gain. In the open market, the rupee strengthened by Rs1.05, reaching 286.55 per dollar.

    The recent appreciation followed a series of actions by law enforcement agencies targeting currency smugglers. Additionally, the State Bank of Pakistan’s decision to slow down its dollar purchases for reserve building has contributed to the rupee’s gains.

    Market analysts noted that the crackdown on illegal currency exchanges, strong remittances, and improving external economic indicators were helping stabilise the currency. 

    Bloomberg, citing Citigroup Inc., reported that while Pakistan’s central bank will continue building its reserves, it will do so at a slower pace, preventing excessive pressure on the rupee.

    In a related development, S&P Global Ratings upgraded Pakistan’s long-term sovereign credit rating on Thursday from ‘CCC+’ to ‘B-’ with a stable outlook, marking the first return to the ‘B-’ rating since July 2022.

    Meanwhile, Pakistan’s dollar bonds also saw a rise, reflecting growing investor confidence in the country’s economic recovery. The yield on the Eurobond maturing in 2031 dropped 55 basis points compared to the previous week, reaching 9.0%, while the yield on bonds maturing in 2036 decreased by 38 basis points to 10%.


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  • Jim Cramer Notes “PepsiCo Sold a Ton of Junk Food.”

    Jim Cramer Notes “PepsiCo Sold a Ton of Junk Food.”

    PepsiCo, Inc. (NASDAQ:PEP) is one of the stocks that Jim Cramer recently commented on. During the episode, Cramer noted that the company “sold a ton of junk food” despite the rise of GLP-1 weight loss drugs. He remarked:

    “PepsiCo’s now up almost 20 points from its low. Why? It’s important to remember that PepsiCo reported a terrific quarter with sugar water, and Frito-Lay, two categories that were supposed to be on life support thanks to the rise of the GLP-1 weight loss drugs; those injections reduce your craving for junk food. PepsiCo sold a ton of junk food.”

    Jim Cramer Notes “PepsiCo Sold a Ton of Junk Food.”

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    PepsiCo (NASDAQ:PEP) produces a wide range of beverages and packaged foods, including snacks, cereals, dairy products, and ready-to-drink offerings, and sparkling water systems. On July 11, Cramer called it a stock “too cheap relative to its growth rate.” He said:

    “If you want to know a stock that’s too cheap relative to its growth rate, but nobody talks about it anymore, why don’t you check out the stock of PepsiCo? It trades at a stunningly low 17 times earnings. I mean, what gives? Well, how about GLP-1 drugs? How about RFK Junior at Health and Human Services, who despises junk food even as he seems to embrace junk science? How about the desire to stay healthy? All these have weighed on PepsiCo stock. Of course, don’t forget they own Frito-Lay. Maybe it’s finally overdone. I don’t know it. It’s a tough industry all of a sudden.”

    While we acknowledge the potential of PEP as an investment, we believe certain AI stocks offer greater upside potential and carry less downside risk. If you’re looking for an extremely undervalued AI stock that also stands to benefit significantly from Trump-era tariffs and the onshoring trend, see our free report on the best short-term AI stock.

    READ NEXT: 30 Stocks That Should Double in 3 Years and 11 Hidden AI Stocks to Buy Right Now.

    Disclosure: None. This article is originally published at Insider Monkey.

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  • Jim Cramer Highlights Short-Term Upside for Conagra

    Jim Cramer Highlights Short-Term Upside for Conagra

    Conagra Brands, Inc. (NYSE:CAG) is one of the stocks that Jim Cramer looked at. When a caller inquired about the company, Cramer commented:

    “Conagra, okay, here’s what’s going to happen with Conagra: In the next two days, Conagra’s going to be up because we’re involved in a rotation, and then on day three, I think you’d want to exit stage right on Conagra.”

    Jim Cramer Highlights Short-Term Upside for Conagra

    bluebay/Shutterstock.com

    Conagra Brands (NYSE:CAG) produces and sells a wide range of packaged food products, including shelf-stable, refrigerated, frozen, and customized items for retail and foodservice. The company markets its products under well-known brands like Birds Eye, Healthy Choice, and Slim Jim. On July 11, Cramer suggested against buying the company stock, as he said:

    “Very tough, very tough situation. Conagra’s got 7% inflation. They got problem with tin cans. They can’t, it’s killing them… The margins aren’t that good. The brands aren’t enabling them to be able to take any price. I have to tell you, the one thing that was important was that, on the conference call, they did say that they think they have no problem paying the dividend. A company that has to answer about whether it has a problem paying the dividend or not is a company that I say [don’t buy, don’t buy, don’t buy].”

    While we acknowledge the potential of CAG as an investment, we believe certain AI stocks offer greater upside potential and carry less downside risk. If you’re looking for an extremely undervalued AI stock that also stands to benefit significantly from Trump-era tariffs and the onshoring trend, see our free report on the best short-term AI stock.

    READ NEXT: 30 Stocks That Should Double in 3 Years and 11 Hidden AI Stocks to Buy Right Now.

    Disclosure: None. This article is originally published at Insider Monkey.

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  • China’s Premier Li proposes global AI cooperation organization – Al Arabiya English

    1. China’s Premier Li proposes global AI cooperation organization  Al Arabiya English
    2. China’s Overlooked AI Strategy: Beijing Is Using Soft Power to Gain Global Dominance  Foreign Affairs
    3. Tech firms to showcase AI innovations in a China under US sanctions  Reuters
    4. Secretary-General of ASEAN Delivers Remarks at the Opening Ceremony of the 2025 World Artificial Intelligence Conference in Shanghai, China  ASEAN Main Portal
    5. Chinese in Silicon Valley: The Useful, Obedient Outsider  China Academy

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  • Interview with Delo

    Interview with Delo

    Interview with Piero Cipollone, conducted by Miha Jenko on 10 July 2025

    26 July 2025

    Mr Cipollone, the ECB is actively exploring the digital euro, the project was launched in July 2021. What are your arguments in favour of the introduction of a digital currency? Is it just a must, something that is necessary in the era of fast-paced digitalisation and of many alternative payment systems and cryptocurrencies, including stablecoins?

    We definitely think that it’s a must, because we need to solve a fundamental problem.

    Central banks do one fundamental thing: they offer a means of payment to the public. Both for retail, day-to-day transactions, and for the wholesale transactions of banks. At the retail level, we provide cash and we will continue to do so. With cash you can pay throughout the euro area in almost every shop. Paying with cash is one of the fundamental freedoms people have.

    However, cash can not be used for a growing part of our day-to-day transactions: we all shop online, but to do that we cannot use cash. And Europeans increasingly prefer to use digital rather than physical means of payments. Today, there is no equivalent of cash for these transactions and we still do not have a European solution to pay digitally throughout the euro area for all our needs and occasions. As a result, we depend on non-European private payment service providers to perform such a basic activity in our life as paying.

    By issuing a digital euro that has exactly the same functions as cash but is digital, we would allow central banks to provide a means of payment to the public to enable them to pay in those cases where physical cash cannot be used. Essentially, we are preserving people’s freedom to pay with public money: cash would be made available in both physical and digital form. And because the digital euro would be legal tender like banknotes and coins, it would be accepted for any digital payments.

    What is the current situation on the way to the digital euro? How do you see the progress made and are you satisfied with the preparations so far?

    There are two dimensions here.

    The first dimension relates to the technical preparations for the digital euro, which is the responsibility of the ECB and euro area central banks. We are progressing on all technical aspects of the project and we are on schedule.

    The second dimension is the legislative process, which will define the digital euro’s regulatory framework. On this side, progress has also been made but the legislation still needs to be finalised. We hope the legislative process can be completed as soon as possible so that we can reflect the choices of the legislators in the development of the digital euro. At the same time we understand that this is a complex project. Both the European Parliament and the Council of the EU – which brings together the ministers from each country – need to fully understand and take ownership of this process.

    In short, while we hope that things move faster on the legislative side, we are making good progress on the technical side.

    Do you feel political support from the European legislators? What is the mood among the politicians?

    At the summit in March, European leaders clearly stated that “accelerating progress on a digital euro is key,” notably to support a competitive and resilient European payment system and contribute to Europe’s economic security. Some details have yet to be agreed upon and we are dealing with them. But we have the highest possible support, and the Heads of State have told us that we need to go ahead with this. For us this is very strong encouragement to continue.

    But what about the people? Europeans eventually expect that the digital euro will provide the highest standards of quality, security, privacy and usability in payment systems. How is all that achievable in the near future?

    This is what we have been working on since we started the digital euro project in 2021. It is a complex project but we have very capable people both at the ECB and at national central banks. We have been identifying the best technical solutions to ensure the greatest degree of simplicity, speed, security and privacy.

    Let me take the example of privacy. The digital euro will provide the highest level of protection.

    First, people will have the possibility to use the digital euro offline, something that so far no digital payment solution offers. In terms of privacy, this will be as good as cash. Only the payer and the recipient will know about the transaction, and no one else.

    Second, when it comes to privacy for the online use of the digital euro, we at the central bank will only see a code for the payer and the payee. By law, we will not be able to identify the participants to the transaction.

    Let me give you another example. We are working on the technical side to provide the very best user experience and we are designing the system so that it is ready for innovation.

    In particular, we are giving banks and payment service providers the possibility to leverage on the digital euro’s technical platform to develop new services that are not yet available today. For instance, we are exploring conditional payments. As of today, users can only link a payment to time: “Pay this person at this point in time.” But users could decide to make a payment conditional on other events, and this would improve people’s lives.

    Here is an illustration. We are experimenting across Europe, conducting tests with users, start-ups, universities, banks. One of the proposed projects involves buying tickets for trains or planes – currently, if you want to get reimbursed in case of delays, you have to go through a lot of hassle. With the digital euro, it would be possible for the payment to be made only if, say, the train arrives on time. This means that the payment is made only if the service is provided in full.

    On the other hand, we know that many Europeans still love cash. For example, in May this year, the Slovenian Parliament even initiated official proceedings to introduce the right to use cash into our constitution. What is your message to the people who are sceptical about using any form of digital money?

    My answer is simple: you will continue to be able to use physical cash. Cash will always be available and everyone will be able to use it. As I said, we are committed to providing cash to society. And we strongly support the legislative proposal by the European Commission to strengthen the mandatory acceptance of cash.

    Moreover, we are designing a digital euro to be a digital form of cash: simple, free, inclusive, protecting privacy and accepted throughout the euro area. In any case, it will only provide an additional option: we will not force anyone to use it. We are guided by one objective: protecting people’s freedom to decide how to pay.

    What about the very young people, the new generations, who frequently use mobile devices? Will you prepare any solution for them?

    We are testing and analysing user solutions and organising focus groups to see people’s preferences. We are asking people about their priorities and how they would use the digital euro. We want to make sure that the product is simple to use and that everyone can understand it. This is the key point: people don’t wake up in the morning thinking, “I’d love to pay for something” – they pay because they want to buy things. So, payments need to be as simple, fast and as reliable as possible. And because the digital euro will be legal tender, you will know that you have a solution you can use to pay wherever digital payments are accepted, in a simple way, by placing your phone next to the payment device. And that you don’t have to worry whether the shop will accept your card or mobile payment app.

    So is the basic idea that the main instrument for executing digital euro payments will be mobile phones and devices?

    We will also provide physical cards to include people who are technologically less savvy or do not have mobile devices. We want to be as inclusive as possible.

    By the end of this year the ECB’s Governing Council will decide whether to move on to the next phase of preparations. What will be the key considerations taken into account in that crucial decision?

    We will assess where we stand in our technical preparations. At the same time, we will look at the discussion at the political level. We will look at whether the circumstances are developing in favour of issuing the digital euro.

    It seems to me that there are important reasons for us to proceed with the project. Political leaders have expressed strong support and even asked us to accelerate progress. We are also seeing a growing public interest. People are telling us that they will use the digital euro if it is available. People understand the importance of having a digital form of cash in cases where it is not possible to use physical cash or where they prefer to pay digitally.

    Who are the main stakeholders you communicate with?

    We’re engaging with everyone – consumers, merchants, payment service providers, policymakers. We see a lot of support.

    For example, consumers are very interested and ask us to ensure that the digital euro will be simple, free for basic use, inclusive.

    Merchants are also very supportive because having an alternative to international card payments would reduce the high fees they pay for digital payment transactions. So they expect a reduction in costs, and they want to be sure that the digital euro will be easy to integrate with existing payment solutions. We recently had a meeting in Frankfurt with representatives of European merchant associations. Their main request was: do it, do it fast and do it simple!

    Banks and payment service providers understand the importance of strategic autonomy. They want to be reassured that there won’t be excessive deposit outflows from bank accounts to the digital euro. In fact, this is not a big risk because the digital euro, as I said, is intended for payments rather than as a store of value. The digital euro will not be remunerated, so we do not expect people to keep high amounts in their digital euro wallet, and in any case there will be a holding limit. Furthermore, even if people do not have enough funds in their digital euro wallet, they will be able to pay with digital euro through a link to their bank account. So again, there will not be a need to keep high amounts in the digital wallet. We are also discussing with banks how to ensure the use of the digital euro within their IT systems in a cost-effective and less burdensome way, and how they will be compensated for the costs they incur. Banks seem to understand the importance of the project.

    Currently, we are living in a very different world compared with two or three decades ago, when the euro project was designed and then launched into the lives of Europeans in the form of coins and banknotes on 1 January 2002. That was the biggest cash changeover in history. And presumably, we are heading to the euro digital changeover in the near future. When will we be able to pay with the digital euro?

    Technically, we will be ready to launch in the next two-and-a-half to three years after the legislation is in place. So a lot depends on the adoption of the legislation. We cannot finalise the digital euro development until the legislation is adopted.

    So we are talking about the year 2028 or 2029?

    Yes, from 2028 onwards. But it really depends on the legislative process. Just an example to help people understand. We are still discussing whether people will be able to have one or several wallets. Technically, this means a completely different design and a different degree of complexity. We cannot finalise the technical specifications until we know what the legislation requires of us. That is why the current timeline very much depends on the legislation being adopted.

    And should the legislation be adopted only at the EU level or also by the national parliaments?

    No, just at the European level. We need the Council and the Parliament to adopt their positions and sit down together with the Commission to agree on a final text.

    Will the digital euro also be used in the countries that haven’t adopted the euro yet?

    No, the digital euro is for the residents of the euro area and for people who travel to the euro area. If a country that is in the EU but outside of the euro area wants to allow its citizens to use the digital euro, it needs to have an agreement between the ECB and its central bank. For countries outside the EU, an agreement is needed with both the government and the central bank.

    In an interview for Expansión in March this year you pointed out that there is a growing sense of urgency as “the situation outside the euro area is a source of pressure and demands greater consideration of the risks we face in payments as a result of our fragility and our extreme dependence on foreign providers”. What kind of risks do you refer to?

    We are currently in a situation where as many as two-thirds of card payments are processed by non-European companies. When you pay by card, our banking sector and payment service providers pay them fees. In addition, mobile payments are expanding their market share and when you pay with a mobile device, banks are losing fees and data. And we know that stablecoins – which are mostly denominated in dollars – are coming, which could take deposits away from banks. This would be a further step toward a deeper dependency of Europe on foreign providers.

    This dependency is a concern for the central bank, as the resilience of payment systems is one of the mandates of central banks. We want to make sure that Europeans can pay independently of other regions of the world, so that we have the means to lead a normal life even if something happens outside the euro area. Right now, we do not have that certainty.

    Yes, we are facing many new geopolitical and economical challenges, many of them coming from the other side of the Atlantic or from China. Given this new context, how could the digital euro boost EU competitiveness and enhance its strategic autonomy, as you’ve just mentioned?

    What I wish to say is that we should be masters of our own destiny. Regardless of what happens. We wish to fix the problem we have. We have had a common currency for 25 years, but when we wish to use it online, we depend on somebody else. This is a concerning situation. And we need to fix it. Just to give you an example: if we do the digital euro, this means that Europe will have a unified infrastructure and a common standard for payments. Payment service providers are very innovative. For example, in Slovenia you have flik and they tell me that it is a very good solution for paying…

    Yes, it is great for small payments.

    So why cannot flik expand outside Slovenia? It is a good solution and people can use it, but the difficulty is the standards. If you have different standards in different countries, it is very difficult for small companies to expand abroad, even if they are very innovative. It is like having to face different languages. But if you have one single standard, one language in common, it is much easier for you to sell your product. That is what we should care about: creating an environment where our companies can compete, grow and become big.

    In an article you wrote in the economics journal Bancaria, you pointed out that digital payments stand at the intersection of information technology and finance. Could you elaborate a little more on that?

    When we discuss and compare ourselves to the United States in the long run and look at the sectoral composition of productivity, we see that the distance between the United States and us is mainly visible in those two sectors: IT and finance. They both have one fundamental characteristic: economies of scale are key, allowing you to increase your productivity. Our companies cannot grow because they operate in a fragmented market. Even if you invent something in Slovenia in these two sectors, it is very difficult to expand your business abroad because of market fragmentation. And you cannot reap the benefits of your increased activity.

    So we need to ensure that our companies in these two fields can easily expand and take advantage of the EU’s single market. A study by the International Monetary Fund, which has been replicated several times, says that the non-tariff barriers that continue to hamper trade within the EU are equivalent to a tariff of 44% for goods and more than 100% for services. So it is important that those two sectors expand as much as possible in Europe, and to do so we need to address remaining barriers within the Single Market. For those two sectors, finance and IT, and for activities at their intersection – such as digital payments – economies of scale are essential to grow and thrive.

    What is the experience of the countries that have already introduced their digital currencies so far? Could we eventually learn something from them?

    The most advanced digital project so far is the Chinese one. But this is a completely different context in terms of rules, for example, a different level of privacy for digital wallets.

    So we focus on addressing the needs of the euro area and the preferences of Europeans, for instance on privacy. It is also very important that the system is very resilient to fraud – that is of great importance to citizens, and is a point that European consumer organisations have placed particular emphasis on.

    In fact, a number of central banks outside the euro area are looking at the progress we are making and reaching out to learn from our work. We in the euro area have a particular sense of urgency because the fragmentation of our payments landscape along national lines is inconsistent with our monetary union and does not allow to reap the full benefits of the Single Market. A digital euro would unify European payments.

    How do you see the ECB’s latest interest rate decision this Thursday (24 July)? What is the rationale behind it? Could we expect more rate cuts in 2025?

    Inflation is at our 2% target and the economy has proven resilient so far in a challenging global environment, but we still face considerable uncertainty, notably in relation to the trade outlook. Against this background, we have decided to leave rates unchanged.

    Trade disruptions make it harder to assess recent data. In the first quarter, the economy grew more strongly than expected, largely because firms frontloaded exports and capital goods investment ahead of expected tariff hikes. In contrast, private consumption growth moderated and the savings rate increased.

    In September – and later this year – we will have more information, which will feed into revised macroeconomic projections. We will then reassess our stance, in line with our data-dependent and meeting-by-meeting approach. In particular, we will be in a better position to assess the trade situation and look through the volatility generated by frontloading effects. This will allow us to better discern the underlying momentum in the economy and its implications for the inflation outlook.

    For now, we see conflicting signals. Weak consumer confidence points to subdued consumption growth in the short term, while continued uncertainty and the unwinding of frontloading effects could weigh on business investment and exports. At the same time, the labour market has so far remained resilient, even as labour demand weakens, and real incomes are rising even as wage growth gradually moderates. Over time, higher public investment in defence and infrastructure is expected to support economic activity. Overall, we continue to see risks to economic growth as tilted to the downside, but the outlook for inflation is more uncertain than usual. In particular, we will need to see how prices in the euro area are affected by trade disruptions – including their impact on supply chains as well as on trade diversion that is already resulting in higher euro area imports from China.

    After ten rate hikes between September 2022 and September 2023, the ECB has lowered borrowing costs eight (or nine) times since last June. What lessons has the ECB learnt from addressing the inflation in the past four years?

    I can tell you the two key lessons I take from the recent episode. First, when sudden inflationary shocks occur, inflation dynamics may change, because there is so-called non-linearity in the system. Inflation can accelerate very fast, especially because firms tend to change prices much faster than we expected. They take many small steps, but frequently. This acceleration is very important and we must take this non-linearity into account.

    Second, the recent inflation spike has confirmed the benefits of keeping inflation expectations under control. If you are able to anchor inflation expectations to your target level, the system will also adjust to this in a soft way. This way the implications of your monetary policy for the real economy may be less severe once you bring inflation expectations back to your target and you can bring back interest rates to lower levels earlier once the inflationary shock unwinds. Keeping inflation expectations close to our 2% inflation target is very important, and it’s one of the principles that we stressed a few weeks ago in our updated monetary policy strategy.

    In this context: what are the main risks to the euro area inflation outlook? Are they to the upside or to the downside right now and why?

    In our latest forecast, in June, we assessed that these risks are really balanced and are tilted neither to the upside nor to the downside. We now see an additional appreciation of the euro and a slight increase in energy costs. The overall assessment therefore stays the same. At that time, we also saw higher trade tensions and some concerns for the global economic outlook, which has so far been resilient. Overall, it seems to me that the June assessment can be confirmed and that inflation expectations are balanced.

    And finally: what lies ahead for the euro area in the context of rising geopolitical tensions and uncertainties, fractured multilateral rules, Trump’s tariffs, increased defence challenges and spending? How to address all these issues and challenges and what should be the role of the ECB in this more complicated and changed world?

    We have one fundamental mission: price stability. So we take all these factors into account and design the monetary policy to make sure that inflation stays at our target level. Price stability and financial stability create the conditions for people and businesses to take their decisions in a stable context, with as little uncertainty as possible. This is the role of the ECB – to provide, within our mandate, a macroeconomic environment that fosters long-term investment and reduces uncertainty for people when taking decisions. That is our key contribution.

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  • CK Hutchison ports deal deadline likely to be extended as geopolitics weigh, sources say – Reuters

    1. CK Hutchison ports deal deadline likely to be extended as geopolitics weigh, sources say  Reuters
    2. How China Built a Global Port Network  The Wall Street Journal
    3. M&A News: BlackRock Stock (BLK) Climbs Despite Threats to $22.8B Panama Ports Deal  TipRanks
    4. China’s Cosco Eyes Veto Rights in Deal for Tycoon Li’s Ports  Bloomberg.com
    5. The looming deadline for the Panama Canal ports deal  The Economist

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  • EV giant to assemble cars from 2026

    EV giant to assemble cars from 2026

    Listen to article


    KARACHI:

    Chinese electric vehicle giant BYD plans to roll out its first car assembled in Pakistan by July or August 2026 to capture growing demand for electric and plug-in hybrid vehicles in the region, a company executive said on Wednesday.

    BYD, the world’s top EV maker, has been expanding rapidly outside its home market, where it is in a strong price war. The Pakistan plant addresses rising demand from emerging markets and allows the company to take advantage of incentives offered by the Pakistani government.

    The plant has been under construction since April near Karachi in a partnership between BYD and Mega Motor Company, a subsidiary of Hub Power, Danish Khaliq, Vice President of Sales and Strategy at BYD Pakistan, told Reuters.

    It would initially have the capacity to produce 25,000 units a year on a double shift, he said. He did not elaborate on when the plant would achieve full capacity or say when mass production would begin there.

    The plant will start by assembling imported parts, with some local production of non-electric components, Khaliq said, adding it would initially produce vehicles for the domestic market, with potential to export to right-hand drive countries in the region depending on freight costs and business economics.

    “We do not foresee excess capacity in our system as demand in Pakistan will catch up,” he said.

    BYD started delivering imported EVs in Pakistan in March. Khaliq did not give an exact sales number but said sales of a few hundred cars had exceeded internal targets by 30%. Khaliq said he expected the market size of EVs and plug-in hybrid cars in Pakistan to grow three to four times in 2025 from around 1,000 total units in 2024. BYD is targeting a 30-35% share of the segment, he said.

    Based on a Hubco filing, BYD Pakistan made around Rs444 million ($1.56 million) in profit in the March 2025 quarter.

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  • Fossil fuel era is fading as shift to renewables becomes “unstoppable”

    Fossil fuel era is fading as shift to renewables becomes “unstoppable”












    Fossil fuel era is fading as shift to renewables becomes “unstoppable” | United Nations











































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  • New Immunotherapy Regimens Aim to Build Upon Durvalumab in Locally Advanced NSCLC

    New Immunotherapy Regimens Aim to Build Upon Durvalumab in Locally Advanced NSCLC

    Although durvalumab (Imfinzi) following concurrent chemoradiotherapy, which was examined in the phase 3 PACIFIC trial (NCT02125461), remains the standard of care, new immunotherapy-based regimens are being developed to offer additional treatment options for patients with locally advanced non–small cell lung cancer (NSCLC), according to Marina C. Garassino, MD.1

    “The old version of the PACIFIC regimen is still the standard of care, but there are many new ‘tastes’ [of this regimen],” Garassino, the director of the Thoracic Oncology Program and a professor of medicine in the Section of Hematology/Oncology at The University of Chicago Department of Medicine in Illinois, said during the presentation during the 26th Annual International Lung Cancer Congress.

    PACIFIC compared durvalumab with placebo for the treatment of patients with unresectable, stage III NSCLC who did not experience disease progression after concurrent chemoradiotherapy.2 Findings from the 5-year survival analysis of the study demonstrated that the median progression-free survival (PFS) in the investigational arm (n = 476) was 16.9 months (95% CI, 13.0-23.9) compared with 5.6 months (95% CI, 4.8-7.7) in the placebo arm (n = 237; stratified HR, 0.55; 95% CI, 0.45-0.68). The median overall survival (OS) values were 47.5 months (95% CI, 38.1-52.9) and 29.1 months (95% CI, 22.1-35.1), respectively (stratified HR, 0.72; 95% CI, 0.59-0.89).

    Garassino emphasized that the benefit of durvalumab was also reflected in a real-world population, based on data from the observational PACIFIC-R study (NCT03798535).3 Patients who received durvalumab (n = 1154) achieved a median OS of not reached (NR; 95% CI, 46.3-not evaluable [NE]). The 2- and 3-year OS rates were 72.3% (95% CI, 69.7%-74.8%) and 63.2% (95% CI, 60.3%-65.9%), respectively. The median PFS was 24.1 months (95% CI, 20.2-27.8); the 2-year PFS rate was 50.1% (95% CI, 47.2%-53.0%), and the 3-year PFS rate was 42.2% (95% CI, 39.2%-45.1%).

    Unpacking Data From Other PACIFIC-Based Regimens

    In the phase 2 PACIFIC-6 trial (NCT03693300), the safety and efficacy of durvalumab were evaluated following sequential chemoradiotherapy in patients with stage III, unresectable NSCLC.4 Patients who received durvalumab (n = 117) achieved a median PFS of 10.9 months (95% CI, 7.3-15.6) and a median OS of 25.0 months (95% CI, 25.0-NE). “Patients were enrolled in this trial if they were not suitable for concurrent treatment,” Garassino commented. “The benefit was very visible, and the treatment was feasible.”

    Garassino noted that there is no benefit in initiating immunotherapy with chemoradiotherapy. Findings from the phase 3 PACIFIC-2 trial (NCT03519971) showed that patients who received durvalumab in combination with chemoradiotherapy (n = 219) experienced a median PFS of 13.8 months (95% CI, 9.5-16.9) compared with 9.4 months (95% CI, 7.5-16.6) among those treated with chemoradiotherapy alone (n = 109; HR, 0.85; 95% CI, 0.65-1.12; P = .247).5

    “There was a crossing of the OS curves that we believe was related to the higher number of adverse effects leading to [treatment] discontinuation with the PACIFIC-2 regimen vs chemoradiation,” Garassino commented.

    Exploring Immunotherapy Regimens Beyond PACIFIC

    In the phase 3 CheckMate 73L study (NCT04026412), investigators compared nivolumab (Opdivo) plus concurrent chemoradiotherapy followed by nivolumab with or without ipilimumab (Yervoy) vs the PACIFIC regimen.6 Patients in the investigational arm (n = 287) experienced a median PFS of 16.7 months (95% CI, 12.6-22.0) compared with 15.6 months (95% CI, 13.7-19.8) in the control arm (n = 318; HR, 0.95; 95% CI, 0.77-1.19; P = .6460).

    The phase 3 GEMSTONE-301 study (NCT03728556) was a Chinese trial that evaluated the PD-L1 inhibitor sugemalimab vs placebo in patients with locally advanced, unresectable stage III NSCLC who did not experience disease progression after concurrent or sequential chemoradiotherapy.7 Data from the interim analysis of GEMSTONE-301 revealed that the median PFS in the sugemalimab arm (n = 255) was 9.0 months (95% CI, 8.1-14.1) compared with 5.8 months (95% CI, 4.2-6.6) in the placebo arm (n = 126; stratified HR, 0.64; 95% CI, 0.48-0.85; log-rank P = .0026).

    The PD-1 inhibitor toripalimab (Loqtorzi) is being evaluated in patients with bulky unresectable stage III NSCLC in the phase 2 InTRist study (NCT05888402).8 Findings from InTRist presented during the 2025 ASCO Annual Meeting showed that patients who received toripalimab plus chemotherapy (n = 27) experienced a median PFS of NR (95% CI, NR-NR) compared with 12.4 months (95% CI, 8.0-NR) among those who received chemotherapy alone (n = 25; HR, 0.26; 95% CI, 0.08-0.81; log-rank P = .012). The 1-year PFS rates were 85.6% (95% CI, 71.6%-100.0%) and 54.5% (95% CI, 37.7%-78.7%).

    “There was a [benefit] in PFS with the combination of chemotherapy and immunotherapy, compared with chemotherapy alone,” Garassino noted. “But we don’t have the results yet in terms of OS, and we need larger studies to [get more data].”

    Durvalumab was examined in combination with multiple novel agents in the phase 2 COAST trial (NCT03822351).9 Findings from COAST revealed that patients who received durvalumab plus monalizumab (n = 62) or durvalumab plus oleclumab (n = 60) experienced a median PFS of 15.1 months (95% CI, 13.6-NE) and NR (95% CI, 10.4-NE), respectively. Comparatively, patients who received durvalumab monotherapy experienced a median PFS of 6.3 months (95% CI, 3.7-11.2); the HRs for PFS using the monotherapy arm as a reference were 0.42 (95% CI, 0.24-0.72) in the monalizumab arm and 0.44 (95% CI, 0.26-0.75) in the oleclumab arm. The 12-month PFS rates in the monalizumab, oleclumab, and durvalumab monotherapy arms were 72.7% (95% CI, 58.8%-82.6%), 62.6% (95% CI, 48.1%-74.2%), and 33.9% (95% CI, 21.2%-47.1%), respectively.

    “[In COAST], we saw good PFS data for the combination arms, and there was also some benefit in patients with PD-L1–negative disease, which we haven’t seen with durvalumab only,” Garassino commented.

    Garassino concluded her presentation by emphasizing that proton pump inhibitors (PPIs) should not be added to the PACIFIC regimen. Findings from a post-hoc analysis of PACIFIC showed that patients in the durvalumab arm who were exposed to PPIs (n = 185) experienced a median PFS of 10.7 months compared with 18.1 months among those who did not receive a PPI (n = 265; P = .017).10 “[These data] showed that adding PPIs can reduce the [efficacy] of immunotherapy, [but there] are still a lot of uncertainties,” Garassino said.

    References

    1. Garassino MC. Immunotherapy in locally advanced NSCLC: latest findings Presented at: 26th Annual International Lung Cancer Congress; July 25-27, 2025; Huntington Beach, CA.
    2. Spigel DR, Faivre-Finn C, Gray JE, et al. Five-year survival outcomes from the PACIFIC Trial: durvalumab after chemoradiotherapy in stage III non-small-cell lung cancer. J Clin Oncol. 2022;40(12):1301-1311. doi:10.1200/JCO.21.01308
    3. Filippi AR, Bar J, Chouaid C, et al. Real-world outcomes with durvalumab after chemoradiotherapy in patients with unresectable stage III NSCLC: Interim analysis of overall survival from PACIFIC-R. ESMO Open. 2024;9(6):103464. doi:10.1016/j.esmoop.2024.103464
    4. Garassino MC, Mazieres J, Reck M, et al. Durvalumab after sequential chemoradiotherapy in stage III, unresectable NSCLC: the phase 2 PACIFIC-6 Trial. J Thorac Oncol. 2022;17(12):1415-1427. doi:10.1016/j.jtho.2022.07.1148
    5. Bradley JD, Sugawara S, Lee KHH, et al. Durvalumab in combination with chemoradiotherapy for patients with unresectable stage III NSCLC: final results from PACIFIC-2.. ESMO Open. 2024;9(suppl 3):102986. doi:10.1016/j.esmoop.2024.102986
    6. Peters S, Tan DSW, Gerber DE, et al. CheckMate 73L: Phase III study comparing nivolumab (N) + concurrent chemoradiotherapy (CCRT) followed by N ± ipilimumab (I) v CCRT followed by durvalumab (D) for previously untreated, locally advanced stage (stg) III NSCLC. IOTECH. 2024;24(suppl):100808. doi:10.1016/j.iotech.2024.100808
    7. Zhou Q, Chen M, Jiang O, et al. Sugemalimab versus placebo after concurrent or sequential chemoradiotherapy in patients with locally advanced, unresectable, stage III non-small-cell lung cancer in China (GEMSTONE-301): interim results of a randomised, double-blind, multicentre, phase 3 trial. Lancet Oncol. 2022;23(2):209-219. doi:10.1016/S1470-2045(21)00630-6
    8. Wang Y, Wang J, Deng J, et al. The preliminary results of a randomized phase II trial evaluating induction toripalimab plus chemotherapy followed by concurrent chemoradiotherapy and consolidation toripalimab in bulky unresectable stage III non-small-cell lung cancer (InTRist). J Clin Oncol. 2025;43(suppl 16):8012. doi:10.1200/JCO.2025.43.16_suppl.8012
    9. Herbst RS, Majem M, Barlesi F, et al. COAST: an open-label, phase II, multidrug platform study of durvalumab alone or in combination with oleclumab or monalizumab in patients with unresectable, stage III non-small-cell lung cancer. J Clin Oncol. 2022;40(29):3383-3393. doi:10.1200/JCO.22.00227
    10. Brunetti L, Santo V, Pinato DJ, et al. Differential effect of proton pump inhibitors (PPIs) and antibiotics (ATB) on clinical outcomes from immunotherapy or placebo in patients with locally advanced, unresectable NSCLC who have not progressed following chemoradiation therapy (cCTRT): a post-hoc analysis of the PACIFIC trial. J Thorac Oncol. 2025;20(3):S129-S130. doi:10.1016/S1556-0864(25)00386-7

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  • Oil Prices Fall Up to 3% This Week Amid Uncertainty Over Trade

    Oil Prices Fall Up to 3% This Week Amid Uncertainty Over Trade

    European Commission President Ursula von der Leyen is scheduled to meet with U.S. President Donald Trump on Sunday in Scotland.


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    Quick overview

    • Oil prices fell to their lowest levels in three weeks due to disappointing economic data from the U.S. and China, along with increasing supply.
    • Brent crude futures dropped 1.1% to $68.42 per barrel, while West Texas Intermediate (WTI) declined 1.4% to $65.12.
    • The decline in oil prices is attributed to a decrease in new orders for core capital goods in the U.S. and a drop in China’s fiscal revenue.
    • Washington is reportedly preparing to allow Chevron and other partners to resume limited operations in Venezuela, impacting market dynamics.

    Oil prices dropped to their lowest levels in three weeks on Friday, pressured by disappointing economic data from the United States and China, as well as signs of increasing supply—despite optimism around potential trade deals that could boost global economic growth and oil demand.

    Brent crude futures fell 76 cents, or 1.1%, to $68.42 per barrel as of 11:44 a.m. Mexico City time, while West Texas Intermediate (WTI) crude in the United States declined 91 cents, or 1.4%, to $65.12.

    The drop put Brent on track for its lowest close since July 4, and WTI heading for its weakest finish since June 30. Over the week, Brent fell nearly 1%, while WTI dropped around 3%.

    USOIL

    European Commission President Ursula von der Leyen is scheduled to meet with U.S. President Donald Trump on Sunday in Scotland, as EU officials and diplomats say they expect to reach a framework trade agreement over the weekend.

    In the United States, new orders for core capital goods unexpectedly declined in June, while shipments rose only moderately—indicating that business spending on equipment likely slowed sharply in the second quarter.

    Meanwhile, in China—the world’s second-largest economy—fiscal revenue dropped 0.3% in the first half of the year compared to the same period in 2024, according to the Ministry of Finance, continuing the trend seen between January and May.

    Adding to the market dynamics, Washington is reportedly preparing to allow PDVSA’s partners—starting with U.S. oil giant Chevron—to resume limited operations in Venezuela, according to sources cited on Thursday.

    Ignacio Teson

    Economist and Financial Analyst

    Ignacio Teson is an Economist and Financial Analyst. He has more than 7 years of experience in emerging markets. He worked as an analyst and market operator at brokerage firms in Argentina and Spain.

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