Category: 7. Science

  • Disrupting protein quality control slows tumor growth in pediatric rhabdomyosarcoma

    Disrupting protein quality control slows tumor growth in pediatric rhabdomyosarcoma

    A new research paper was published in Volume 16 of Oncotarget on August 29, 2025, titled “In vivo manipulation of the protein homeostasis network in rhabdomyosarcoma.”

    In this study led by first author Kristen Kwong and corresponding author Amit J. Sabnis from the Department of Pediatrics, Division of Oncology, University of California San Francisco, researchers discovered that disrupting the protein quality control system in cancer cells slows tumor growth in rhabdomyosarcoma (RMS), the most common pediatric soft tissue cancer. This finding points to a new strategy for treating high-risk childhood cancers that often resist current therapies.

    Rhabdomyosarcoma is a rare and aggressive cancer that primarily affects children and adolescents. Standard treatments like chemotherapy and radiation often have limited long-term success in high-risk cases. This study explored a different approach: targeting the cellular machinery that maintains protein quality, known as the proteostasis network. Cancer cells rely heavily on this system to survive stress caused by rapid growth and genetic instability.

    “To examine whether MAL3-101 or more drug-like proteostasis inhibitors represent a new therapeutic strategy for RMS, we screened proteostasis components that might recapitulate the effects of MAL3-101 in vivo.”

    The researchers first used a compound called MAL3-101 to disrupt protein control in RMS cells. They then identified which parts of the protein quality system were affected. Based on those findings, they searched for more drug-like compounds that could target the same pathways. 

    They focused on a protein called p97, which plays a critical role in removing damaged or misfolded proteins. When they blocked p97 using a drug called CB-5083, the cancer cells could no longer manage internal stress and began to self-destruct. In both laboratory models and mice implanted with human RMS tumors, the treatment significantly slowed or stopped tumor growth. The drug triggered a stress response in the cells known as the unfolded protein response, which can lead to either recovery or programmed cell death.

    However, not all tumors responded the same way. Some resisted the treatment by activating a backup system called autophagy, which allows cells to recycle parts of themselves under stress. By comparing tumors that responded well to those that did not, the researchers found that higher autophagy activity could serve as a warning sign for resistance. This insight may help identify which patients are more likely to benefit from therapies that target protein quality control.

    While the results are promising, the drug’s effectiveness depended on the tumor’s genetic profile and how it handled stress. Combining p97 inhibition with other treatments or blocking alternative survival pathways like autophagy may improve outcomes. The researchers also noted the importance of developing safer and more targeted drugs to reduce side effects.

    This study opens new possibilities for personalized cancer treatment, particularly for children with aggressive or relapsed RMS. By weakening the systems that cancer cells depend on to survive, rather than only using toxic treatments to kill them, scientists aim to develop more effective and less harmful therapies for young patients.

    Source:

    Journal reference:

    Kwong, K., et al. (2025). In vivo manipulation of the protein homeostasis network in rhabdomyosarcoma. Oncotarget. doi.org/10.18632/oncotarget.28764

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  • ’Strangest’ dinosaur covered in spiked armory: scientists – Arab News PK

    ’Strangest’ dinosaur covered in spiked armory: scientists – Arab News PK

    1. ’Strangest’ dinosaur covered in spiked armory: scientists  Arab News PK
    2. ‘Punk rock’ dinosaur with metre-long spikes discovered  BBC
    3. Oldest Known Fossil of an Armored Ankylosaur Is ‘Far Weirder’ Than Paleontologists Expected  Smithsonian Magazine
    4. “We’ve never seen anything like this in any animal before”: why this armoured dinosaur is one of the strangest ever discovered  BBC Wildlife Magazine
    5. ‘Strangest’ dinosaur covered in spiked armory: scientists  Arab News

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  • Chemistry in pictures: Glow-in-the-dark succulents

    Chemistry in pictures: Glow-in-the-dark succulents

     

    These succulents got a glow up from researchers in China who injected the plants with inorganic phosphor particles (Matter 2025, DOI: 10.1016/j.matt.2025.102370). The science behind the glow is the same as in many paints and stickers found in children’s rooms the world over: Light puts the material into an excited state, and then energy is slowly released as a glow that can last for hours.

    Researchers have made glow-in-the-dark plants before, for example, by adding bioluminescent pathways from mushrooms into plants. You can even buy green-glowing petunias based on that technology in the US. But these new glowing house plants come in a much wider variety of colors because chemists have developed a wide range of phosphor materials over the years.

    The succulents were made by a team of researchers, led by Xuejie Zhang at South China Agricultural University, who realized that the plants’ compact microstructure and abundant intercellular spaces are ideal for injection with glow-in-the-dark microparticles. The researchers patented their technology and hope that it could lead to living light features in the future.

    Credit: Matter 2025, DOI: 10.1016/j.matt.2025.102370

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    See more Chemistry in Pictures.

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  • Hubble sees Supernova 1987A clearly

    Hubble sees Supernova 1987A clearly

    Today in the history of astronomy, NASA announces new details about our neighborhood supernova.

    • Supernova 1987A, resulting from the death of a massive star in the Large Magellanic Cloud, first became visible on Earth on February 23, 1987.
    • The Hubble Space Telescope, beginning in 1990, captured high-resolution images of SN 1987A, providing detailed observations of the supernova remnant.
    • Hubble observations in August 1990 revealed a previously unseen, approximately 1.3 light-year-wide elliptical ring of material surrounding the supernova remnants, identified as the remains of a stellar envelope ejected ~10,000 years prior to the star’s death.
    • Subsequent observations by Hubble, Chandra, and ALMA have continued to provide data on SN 1987A, furthering the understanding of stellar evolution and generating additional research questions.

    The first light from the explosion that was the death of a massive star in the nearby Large Magellanic Cloud reached Earth on Feb. 23, 1987. Supernova 1987A’s proximity gave astronomers unprecedented access into the final stages of stellar life, and in 1990, the Hubble Space Telescope began taking high-res images of the former star. Then, on Aug. 29 of that year, NASA announced that Aug. 23-24 observations had resolved a ring of material around the supernova remnants in unparalleled detail: Hubble revealed the glowing remains of the explosion were surrounded by an elliptical halo about 1.3 light-years across. The star had ejected hydrogen about 10,000 years before its death, and the luminescent ring was the remains of that stellar envelope. Hubble and other observatories, including Chandra and the Atacama Large Milimeter/submilimeter Array (ALMA), have continued to image SN 1987A since, providing astronomers with insights into stellar evolution and death – and further questions and unknowns to investigate.

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  • Acidification May Erode Sharks’ Teeth Faster Than They Can Grow Back, Study Finds

    Acidification May Erode Sharks’ Teeth Faster Than They Can Grow Back, Study Finds

    “Jaws” helped shape the global perception of great white sharks, but it shaped it all wrong. Photo: Unsplash


    The Inertia

    Teeth are just one factor that put some shark species at the top of the ocean food chain. They can be razor sharp, and number in the hundreds in one shark’s mouth alone. They fall out and grow back at rates that are absolutely fascinating. Unlike us, sharks have an endless supply of teeth. They lose them as frequently as every few days or weeks, and how fast they grow back is critical for species like bull sharks, for example, that can have as many as 300 teeth filling up a dozen rows.

    But those chompers might be in trouble, says research published this week by a group of German scientists, suggesting ocean acidification threatens those all-important teeth. In short, it could impact tooth regrowth negatively and prevent them from growing back at a rate that keeps up with how fast they fall out.

    “As shark tooth roots are not protected by soft tissue, unlike in mammals, they are naturally exposed to surrounding water. This exposure makes them especially susceptible to pH-induced degradation, notably in the osteodentine-rich regions,” the researchers explained in the new study.

    To test the impact, the researchers kept 60 teeth from black tip reef sharks that had recently fallen out and placed them in artificial seawater tanks. One tank matched the ocean’s current average pH of 8.1, another had water with 7.3 pH, which is an acidification level projected for the year 2300. After eight weeks in those tanks, the teeth in the tank with increased acidification levels showed “increased root corrosion … and altered serration.”

    “The damage we observed to enameloid and dentin layers underlines that even the typically more crystalline components of shark teeth are not immune to acidification,” the scientists wrote in conclusion. “Degradation of the crown structure could compromise the mechanical properties of teeth, especially in regions involved in prey capture and processing. Increased serration, while potentially beneficial for cutting efficiency, might lead to structural weakness and higher susceptibility to breakage.”

    “It will be interesting to see in future studies if the damage to teeth seen in studies like this one results in a functional effect on a tooth’s ability to do its job … [and if] damaged teeth can still cut or puncture prey,” Lisa Whitenack, a professor at Pennsylvania’s Allegheny College told The Guardian.


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  • Extremely stripped supernova reveals a silicon and sulfur formation site

    Extremely stripped supernova reveals a silicon and sulfur formation site

    Recreation of supernova SN 2021yfj. Keck Observatory / Adam Makarenko

    Stars are initially powered by the fusion of hydrogen to helium. These ashes serve as fuel in a series of stages, transforming massive stars into a structure of shells. These are composed of natal hydrogen on the outside and consecutively heavier compositions inside, predicted to be dominated by He, C/O, O/Ne/Mg and O/Si/S. Silicon and sulfur are fused into iron, leading to the collapse of the core and either a supernova explosion or the formation of a black hole Stripped stars, in which the outer hydrogen layer has been removed and the internal He-rich or even the C/O layer below it is exposed, provide evidence for this shell structure and the cosmic element production mechanism it reflects. The supernova types that arise from stripped stars embedded in shells of circumstellar material (CSM) confirm this scenario. However, direct evidence for the most interior shells, which are responsible for producing elements heavier than oxygen, is lacking. Here we report the discovery of the supernova (SN) 2021yfj resulting from a star stripped to its O/Si/S-rich layer. We directly observe a thick, massive Si/S-rich shell, expelled by the progenitor shortly before the supernova explosion. Exposing such an inner stellar layer is theoretically challenging and probably requires a rarely observed mass-loss mechanism. This rare supernova event reveals advanced stages of stellar evolution, forming heavier elements, including silicon, sulfur and argon, than those detected on the surface of any known class of massive stars…

    Nature: Extremely stripped supernova reveals a silicon and sulfur formation site

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  • Geology major investigates the formation of diamonds deep within the Earth

    Geology major investigates the formation of diamonds deep within the Earth

    Diamonds are the hardest mineral on Earth, useful in industry and sought after for their beauty. But for scientists, they also offer a window into the deep underground, giving us a glimpse into the mysterious processes that create and shape rock.

    Binghamton University senior Kate Halpin had the opportunity to study diamond geochemistry this summer during an internship at Carnegie Science in Washington, D.C.

    A love for the outdoors initially sparked the Long Island native’s curiosity about the world around her and the unseen processes that shape landscapes and rock formations. During her first year at Binghamton, she took a class with Associate Professor Alex Nikulin on earthquakes and volcanoes that proved transformative.

    “I realized that it was something I wanted to pursue. The more I learn about geology, the more I’m curious about it,” explained Halpin, a geology major.

    Looking for an internship to help prepare for graduate school, Halpin discovered a list of Research Experience for Undergraduates (REU); Carnegie Science was considered one of the best. She spent 10 weeks in the nation’s capital, investigating a geological paradox: The composition of a particular set of rocks from southern Africa wasn’t considered favorable for the formation of diamonds. Why, then, were diamonds scattered through them like raisins in bread?

    The rocks in question come from the Liqhobong kimberlite pipe in Lesotho, Africa, formed by explosive volcanic eruptions that bring material from deep within the Earth to the surface.

    “The kimberlite eruption carries the diamonds from depths that we can’t access up to the surface, and that’s how we can study them,” Halpin explained. “It’s like a window into deep earth processes.”

    The researchers looked at tiny inclusions of other material contained within the diamonds, which offered insight into the composition of the Earth’s mantle and other dynamics at a depth underground that today’s scientists cannot reach.

    That involved the use of specialized, high-tech equipment, such as an electron microprobe that uses a focused electron beam to ascertain the chemical composition of minerals. A high-resolution technique known as nanoscale secondary ion mass spectrometry (NanoSIMS) detected carbon isotopes within the diamonds, while cathodoluminescence spectroscopy gave insight into the diamonds’ growth history.

    The researchers also used Fourier Transform Infrared Spectroscopy (FTIR), which analyzes how minerals absorb infrared light to identify chemical bonds and molecular structures. Specifically, they looked at how much nitrogen the diamonds contained, which allowed them to estimate how long the diamonds spent in the mantle and the temperature they experienced.

    Before the various types of scans, the diamond samples need to be prepared — hence the polishing.

    “Given that diamonds are the most scratch-resistant mineral in the world, polishing was no simple task. One of the major challenges I faced this summer was learning how to prepare diamond samples for analysis,” Halpin explained. “This involved a significant amount of trial and error using various techniques, and ultimately using a diamond polishing wheel and ion milling machine.”

    Next steps

    Diamonds aren’t the only mineral involved in the researchers’ analysis; the Carnegie scientists also looked at garnets in the host rock, since garnets form under similar pressures and temperatures as diamonds.

    They discovered something interesting: the inclusions inside the diamonds revealed chemical fingerprints pointing to subducting oceanic crust and recycled sediments, while the host rock had a different origin. This information sheds light on the complex processes that create diamonds, a question researchers are still working to fully understand.

    “The diamonds formed under completely different conditions than the host rocks did and at different times,” Halpin explained. “We’re still trying to understand the processes of formation.”

    During the internship, Halpin collaborated with both peers and Carnegie scientists. Interns gave weekly presentations about their research and attended seminars on scientific communication, graduate school and how to write scientific abstracts; they also learned about research conducted by Carnegie scientists, from monitoring volcanic eruptions to measuring the Earth’s magnetic field.

    Back at Binghamton, Halpin is continuing to work on the Carnegie research project remotely, analyzing data, helping prepare a manuscript for publication, and creating a research poster. In December, she will share her findings in New Orleans at the 2025 American Geophysical Union’s annual meeting, the largest international earth and space conference in the world.

    It will be her first conference, and she’s looking forward to reconnecting with her fellow interns there.

    “It’s been such a great summer,” Halpin reflected. “I’ll definitely never forget it.”

    She’ll also use what she learned about ancient geologic processes in her senior thesis. Working with Distinguished Professor Tim Lowenstein, she is also exploring fluid inclusions in salt crystals, which provide insight into the composition of ancient seawater.

    “Kate Halpin’s lab work and depth of understanding stand with the very best students in Earth Science. It is great to see Kate get a career start at Carnegie Science and come back to Binghamton, a ‘new’ person enthusiastic to begin a senior thesis project,” Lowenstein said.

    This fall, she plans to apply to doctoral programs in geochemistry. She’s open to whatever the future brings, whether that entails teaching, research or both, she said.

    “Many researchers collaborate with NASA to answer questions in both geochemistry and planetary science. I’ve always been fascinated by space, and this is something that I would love to explore further,” Halpin said. “At Carnegie, I met scientists who utilize meteorites to reveal clues about the formation of the solar system and the history of planets, including our own. If I could do that in some capacity, it would be incredibly fulfilling.”

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  • Next Week, A Record-Breaking Over 7 Billion People Will See The Total Lunar Eclipse

    Next Week, A Record-Breaking Over 7 Billion People Will See The Total Lunar Eclipse

    Get ready for the Blood Moon next week! Our natural satellite will turn crimson as it is experiencing a total eclipse. It will happen during the evening between September 7 and 8 (depending on the timezone) and will be seen by an enormous number of people worldwide. The moon will first go black as the Earth’s shadow covers it during the partial phase, before going full red, when it is completely eclipsed. The full event, from partiality to the full eclipse and then back to partiality, will take 3 hours, 29 minutes, and 24 seconds.

    Where Will The Blood Moon Be Visible From?

    If you want to see the whole spectacle from start to finish (including the dimming of the penumbral phase), you have plenty of places to pick from. Most of Asia, a sliver of East Africa, and Western Australia will get the complete eclipse. The rest of Africa, Australia, much of Europe, and the east coast of Brazil will get at least part of the totality and the partiality.

    You can check Time&Date.com for precise timings to see the eclipse at your location. 

    How Is This Lunar Eclipse Record Breaking?

    Thanks to the planetary alignment at the time of the eclipse, a record-breaking 7 billion people will be able to see the celestial event.  Obviously, weather permitting, but up to 60 percent of the world’s population will be able to see the full eclipse, which is truly incredible.

    If we consider at least partial views of the event, then the number goes up to 87 percent. We’re sure people in the Americas will be annoyed that they were not invited to this party… let’s consider it a cosmic retaliation for the first lunar eclipse of 2025, which took place in March and was basically an American exclusive.

    For the March eclipse, the lunar mission Blue Ghost was on the Moon and operational at the time. It captured the incredible event as a solar eclipse, which you can see here. 

    To consider a completely different record, the longest eclipse observation, and likely the one with the least spectators, happened back in 1973, where scientists used a Concorde plane to travel across the path of totality for 74 minutes.

    Excitingly, the longest eclipse of this century is still to come. It will happen on August 2, 2027, and it will last around 6 minutes and 23 seconds.

    How Do Eclipses Happen?

    The orbit of the Moon is slightly slanted with respect to the orbit of the Earth around the Sun. If the two were the same, we would get a lunar and solar eclipse every month. Instead, they tend to happen more rarely, every six months or so (but certain years are better) when the Moon is at a node.

    A node means that the Sun, the Earth, and the Moon are aligned or in syzygy. A total lunar eclipse occurs at full Moon when the Sun, the Earth, and the Moon line up, so the Moon passes completely within the shadow. There are partial lunar eclipses, where the Moon doesn’t fully enter the shadow, and penumbral eclipses when the Moon only crosses the half-shadow.

    For the Sun, there are total eclipses when the Sun is fully covered, partial, when only a bit of the Sun is obscured, and annular, when the Sun is fully covered but the Moon is at its most distant point in its orbit, so it doesn’t look big enough to block the whole solar disk.

    The total lunar eclipse is also known as the blood Moon because, once in the shadow of the Earth, it turns red. The reason for this is that sunlight filters through the atmosphere of the Earth, losing the blue colors, just like the sky at sunset and sunrise. Our planet’s shadow has a bit of a crimson hue, coloring the Moon when no direct sunlight is reaching it.

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  • Scientists watch a single electron move during a chemical reaction for first time ever

    Scientists watch a single electron move during a chemical reaction for first time ever

    For the first time, scientists have used ultrafast X-ray flashes to take a direct image of a single electron as it moved during a chemical reaction.

    In the new study, published Aug. 20 in the journal Physical Review Letters, the researchers accomplished this incredible feat by imaging how a valence electron — an electron in the outer shell of an atom — moved when an ammonia molecule broke apart.

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  • A New Method For Producing Oxygen Using Magnets

    A New Method For Producing Oxygen Using Magnets

    In space, the one thing more important than ensuring access to food, water, and waste disposal (combined!) is the need for a steady supply of breathable air. Where the International Space Station (ISS) and other missions in Low Earth Orbit (LEO) can be resupplied regularly, missions operating in deep space will need to produce their own. There are several ways to go about this. One way is to use bioregenerative life support systems (BLSSs), which utilize photosynthetic organisms (like cyanobacteria) that take in carbon dioxide and produce oxygen gas and edible algae.

    Another way is to produce oxygen gas from local resources, a process known as in-situ resource utilization (ISRU). This typically involves electrolysis, a process in which electric current is used to split water molecules into hydrogen and oxygen gas. However, this process is impractical for deep-space missions because of the amount of energy required, not to mention the fact that it does not work well in microgravity. In a recent study, an international team suggests an alternative method that relies on a process known as magnetic phase separation.

    The research was led by Álvaro Romero-Calvo, a recent PhD graduate from the University of Colorado Boulder who is currently an Assistant Professor at the Daniel Guggenheim School of Aerospace Engineering, part of the Georgia Institute of Technology. He was joined by researchers from the Center of Applied Space Technology and Microgravity (ZARM) at the University of Bremen, and the University of Warwick. The paper detailing their findings was published on August 18th in Nature Chemistry.

    Mockup of the Oxygen Generation System Rack. Credit: NASA

    As noted, the current method for producing oxygen in space is through electrolysis, where electrodes immersed in an electrolyte solution (like salt) split water molecules into oxygen and hydrogen. Aboard the ISS, this is done by the Oxygen Generation Assembly (OGA), which spins water in a centrifuge to separate oxygen and hydrogen gas bubbles from the liquid. In microgravity, however, gas bubbles do not float upwards, and those produced in the centrifuge tend to remain suspended and stick to the electrodes. To extract them, a complex fluid management system is used that is heavy, complex, and occupies a lot of space.

    This makes such a system impractical since it would be very difficult to take on long-duration crewed missions. This was the conclusion reached by a team from NASA’s Ames Research Center who evaluated the OGA for crewed missions to Mars. Per the report, the team recommended that the OGA “for Mars should have lower mass, better reliability and maintainability, greater safety, radiation hardening, and capability for quiescent operation. NASA’s methodical, disciplined systems engineering process should be used to develop the appropriate system.”

    To address this problem, the team proposed an alternative solution that uses magnetism, which could make future life support systems lighter, simpler, and more sustainable. As Romero-Calvo said in a Georgia Tech news release:

    One may think that extracting gas bubbles from liquids in space is as simple as opening a can of soda here on Earth. However, the lack of buoyancy makes the extraction process incredibly difficult, undermining the design and operation of oxygen production systems. In this paper, we demonstrate that two largely unexplored magnetic interactions – diamagnetism and magnetohydrodynamics – provide an exciting pathway to solve this problem and develop alternative oxygen production architectures.

    The team created their system using off-the-shelf permanent magnets, which they tested at the ZARM Drop Tower in Bremen – a 146 m (~480 ft) high tower that simulates microgravity. The team also developed a passive phase separation system that collects the bubbles from the electrodes at designated spots. From this, they were able to demonstrate that magnetic fields can enable the separation of gas bubbles from electrodes in a microgravity environment without the need for heavy, complex equipment. The experiments further confirmed that magnetic forces can improve gas bubble detachment and enhance the efficiency of the electrochemical cells by up to 240%.

    41557_2025_1890_Figa_HTML_20250828_224725.png

    A key part of this breakthrough is the two complementary approaches the team developed to collect oxygen bubbles from the electrode. The first takes advantage of how water responds to magnets in microgravity by guiding gas bubbles toward collection points, while the second employs magnetohydrodynamic forces. These forces arise naturally from the interaction between magnetic fields and electric currents generated by electrolysis, creating a spinning motion in the liquid that separates gas bubbles from water through convective effects.

    This process achieves the same phase separation as mechanical centrifuges, like the one used aboard the ISS, but it uses magnetic forces instead of mechanical rotation. “We were able to prove that we do not need centrifuges or any mechanical moving parts for separating the produced hydrogen and oxygen from the liquid electrolyte,” said co-author Katerina Brinkert, an Honorary Professor at the University of Warwick and the Director of ZARM. “We do not even need additional power. Instead, it is a completely passive, low-maintenance system.”

    “Our team was able to prove that magnetic forces can feasibly control electrochemical bubbly flows in microgravity, departing from the state-of-the-art in low-gravity fluid mechanics and enabling future human spaceflight architectures,” Romero-Calvo added. The team’s work is the result of four years of joint research based on Romero-Calvo’s original idea, calculations, and numerical simulations. To validate the theory, Prof. Brinkert’s team at Warwick and ZARM developed the necessary experiments and devices to test the proposed method in microgravity conditions. As Dr. Shaumica Saravanabavan, a Ph.D. researcher at the University of Warwick, said:

    During my trips to ZARM, we confirmed the magnetic buoyancy effect for phase separation in (photo-)electrolysis cells in multiple Drop Tower experiments, using electrode materials we in part fabricated at Warwick. I’m proud to have contributed to advancing sustainable energy technologies beyond Earth applications.

    This research presents opportunities for developing simpler, more cost-effective, and more sustainable life support systems for deep-space missions. In the near future, the team hopes to further validate their method by launching it to orbit, where the system can operate in microgravity for extended periods.

    Further Reading: University of Warwick, Nature Chemistry

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