- Scientists Build Synthetic Cells That Tell Time SciTechDaily
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- Reconstitution of circadian clock in synthetic cells reveals principles of timekeeping Nature
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Category: 7. Science
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Scientists Build Synthetic Cells That Tell Time – SciTechDaily
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Colossal flood explodes through Greenland Ice Sheet. What scientists find in aftermath astounds them
In 2014, a lake hidden beneath the Greenland Ice Sheet suddenly began to drain. The event occurred with such force that a surge of water was sent directly upwards, splitting through the ice to create a crater almost one kilometre deep.
In the 10 days that followed, 90 million cubic metres of water were released from the lake – roughly equivalent to nine hours of water crashing over Niagara Falls during peak flow. It was one of the largest subglacial floods ever recorded in Greenland.
Despite the drama of the event itself, researchers were even more surprised by what they discovered downstream: 385,000 square metres (54 football pitches) of fractured and distorted ice – a chaotic scene that comprised enormous blocks 25 metres high, along with six square kilometres of scoured ice. None of this was there before the flood.
Now, in a new study published in the journal Nature Geoscience, researchers from Lancaster University reveal further insights not only on the discovery of the great flood but also how this little-understood process may affect the way the ice sheet responds to future climate change.
Using data from several Earth-observing satellites, scientists have discovered that a huge subglacial flood beneath the Greenland Ice Sheet occurred with such force that it fractured the ice sheet, resulting in a vast quantity of meltwater bursting upwards through the ice surface. Credit: ESA/CPOM/Planetary Visions The flood
The study explains that “one of the most recently discovered, yet poorly understood, components of Greenland’s subglacial hydrological system is its network of active subglacial lakes.” The 2014 lake drainage event therefore presented an opportunity to find out more.
Using high-resolution surface models and multiple satellite sources from NASA and the European Space Agency, the team were able to study the lake – and the flood event – in striking detail. They were surprised at what they found.
“When we first saw this, because it was so unexpected, we thought there was an issue with our data,” explains lead author Dr Jade Bowling. “However, as we went deeper into our analysis, it became clear that what we were observing was the aftermath of a huge flood of water escaping from underneath the ice.”
Satellite image of the subglacial lake region acquired on 12 August 2012, before the subglacial lake drainage and outburst flood occurred. Credit: CPOM, Lancaster University | DigitalGlobe, Inc. (2015), provided by European Space Imaging Satellite image of the subglacial lake region acquired on 28 April 2015, after the subglacial lake drainage and outburst flood occurred, showing the fracturing of the ice sheet. Credit: CPOM, Lancaster University | DigitalGlobe, Inc. (2015), provided by European Space Imaging. Previously, it was thought that meltwater flowed from the surface down to the bed and out to the ocean. This event, however, shows that water can also be forced in the opposite direction, tearing upwards through the ice under pressure.
Approximately one kilometre downstream of the collapsed basin, a newly formed zone of fractures appeared in the ice surface, “consisting of crevassing and uprooted ice blocks with a combined height (crevasse depth plus ice block height) of 40 metres,” the study explains.
“Downslope of the fracture zone, an ~6-km2region of the ice surface had been scoured clean. Together, these observations indicate that a substantial volume of water broke up through the ice at this location and flooded across the surface.”
The scientists were also surprised to find that the flood occurred in a region where models previously predicted that the ice was frozen at the bed. Given the existence of the lake, this can’t be the case.
The researchers suggest perhaps the pressure-driven fracturing of ice along the ice bed created a pathway for the water to flow.
Diagram showing how the subglacial lake formed and what happened when it flooded. Credit: Bowling et al., Nature Geoscience Lessons from the flood
“What we have found in this study surprised us in many ways,” says Dr Amber Leeson, an expert in ice sheet hydrology. “It has taught us new and unexpected things about the way that ice sheets can respond to extreme inputs of surface meltwater.”
The findings raise questions about whether current models accurately capture the behaviour of the Greenland Ice Sheet under a warming climate, say the researchers, who explain that as global temperatures rise, more meltwater events like this could happen – yet we still have much to learn about how they affect the future of our ice sheets.
Find out more about the study: Outburst of a subglacial flood from the surface of the Greenland Ice Sheet
Top image: the outburst fracture zone, based on satellite imagery acquired on 28 April 2015. Credit: CPOM, Lancaster University | DigitalGlobe, Inc. (2015), provided by European Space Imaging
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Skyfall Is the World's First-Ever Drone Carrier Designed to Work On Alien Worlds – autoevolution
- Skyfall Is the World’s First-Ever Drone Carrier Designed to Work On Alien Worlds autoevolution
- NASA Concept Would Release an Autonomous Helicopter Swarm on Mars extremetech.com
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NASA tests sensor-equipped supersonic parachutes for safer Mars missions
Questions and answers:
What is the purpose of NASA’s EPIC parachute research project? NASA’s EPIC (Enhancing Parachutes by Instrumenting the Canopy) project aims to improve the performance and reliability of supersonic parachutes used in planetary missions by testing flexible sensors embedded in the parachute canopy.
How do the sensors used in the EPIC project work? The sensors are designed to measure strain without interfering with parachute function. They provide real-time data during test flights to validate computer models and inform future designs.
Who is leading the EPIC research and where is it based? The EPIC team is led by NASA’s Armstrong Flight Research Center in Edwards, Calif., with support from Ames Research Center and Langley Research Center.
EDWARDS, Calif. – National Aeronautics and Space Administration (NASA) researchers are conducting a series of flight tests to improve the reliability and safety of supersonic parachutes used in Mars missions by outfitting them with flexible, nonintrusive sensors.
Led by the EPIC (Enhancing Parachutes by Instrumenting the Canopy) team at NASA’s Armstrong Flight Research Center, the tests aim to gather data to refine parachute performance models. In a June demonstration, a quadrotor drone dropped a test capsule that successfully deployed a parachute embedded with strain-measuring sensors. As expected, the sensors did not interfere with the parachute’s function and also provided valuable performance data.
“Reviewing the research flights will help inform our next steps,” said EPIC project manager Matt Kearns. The team is now working on temperature testing, data analysis, and future instrumentation while engaging with potential partners to explore broader applications.
AeroVironment, JPL unveil Skyfall Mars helicopter concept for 2028 mission
The effort is part of NASA’s Entry Systems Modeling project, funded by the agency’s Space Technology Mission Directorate and based at NASA’s Ames Research Center in California. The parachute and capsule system was developed by NASA Langley Research Center in Virginia, while interns at NASA Armstrong helped integrate a test version for flight.
Initially, the project focused on identifying and bonding commercial flexible sensors. The ongoing work could also benefit other industries, such as aerospace and auto racing, by improving high-speed parachute systems.
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Chinese scientists synthesize meteorite diamond harder than Earth diamond-Xinhua
BEIJING, July 31 (Xinhua) — Chinese researchers have succeeded in synthesizing the hundred-micron-scale hexagonal diamond, a material primarily found in meteorites, which is harder than the ordinary diamond found on Earth.
The study, published on Wednesday in the journal Nature, promises to redefine the limits of superhard materials, according to the researchers.
The Earth diamond owes its reputation as the king of hardness to its carbon atoms arranged in a tetrahedral lattice, making it extremely hard and wear-resistant.
However, this structure has a weakness — certain planes can easily slip and shift when force is applied, thereby limiting its strength. As a consequence, scientists have turned their attention to another type of super diamond with a more exquisite structure and superior properties, namely the hexagonal diamond.
Chinese researchers involved in the published study innovatively proposed a method for transforming graphite into a hexagonal diamond. Under controllable high-temperature, high-pressure and quasi-hydrostatic conditions, they compressed and heated graphite single crystals to ultimately obtain a high-purity hexagonal diamond.
Previous attempts to synthesize a hexagonal diamond were largely unsuccessful due to extremely stringent formation requirements. Under high-temperature and high-pressure conditions, the end result tends to be the formation of a cubic diamond and not a hexagonal diamond.
The successful synthesis of a high-purity hexagonal diamond by the Chinese research team is attributed to their choice of high-purity natural graphite single crystals, as well as their use of high-pressure in-situ X-ray observation to monitor changes in samples, said Yang Liuxiang, one of the authors of the paper and a researcher at the Beijing-based Center for High-Pressure Science & Technology Advanced Research.
This study lays a methodological foundation for future research on diamond-like materials, according to Ho-kwang Mao, a scientist in high-pressure science and a foreign member of the Chinese Academy of Sciences.
This synthesized hexagonal diamond is expected to pave new pathways for the development of superhard materials and high-end electronic devices, Mao added. ■
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Intersectin Controls Brain Cell Communication Timing
Researchers at Johns Hopkins Medicine say they unexpectedly found new information about a protein’s special role in getting brain cells to communicate at the right time and place in experiments with genetically engineered mice.
The finding about the protein intersectin, they say, advances scientific understanding of a key process in how the mammalian brain forms memories and learns, and may help advance treatments for cognitive disorders including Down syndrome, Alzheimer’s disease and Huntington’s disease.
A report of the new findings, funded in part by the National Institutes of Health, was published July 8 in the journal Nature Neuroscience.
Specifically, the researchers found that intersectin keeps tiny, message-carrying bubbles inside brain cells in a particular location until they are ready to be released to activate a neighboring brain cell. The protein does so by creating a physical boundary between these bubbles, similar to how oil separates from water.
Message transfer from brain cell to brain cell is key to information processing, learning and forming memories. The bubbles, synaptic vesicles, are housed within the synapse — the connection point where brain cells communicate. In typical synapses within the brains of mammals, 300 synaptic vesicles are clustered together in the intersection between any two brain cells, but only a few of these vesicles are used for such message transfer, researchers say. Pinpointing how a synapse knows which vesicles to use has long been a target of research by those who study the biology and chemistry of thought.
“We found that these tiny bubbles have a distinct domain where they want to be,” says Shigeki Watanabe, Ph.D., associate professor of cell biology at Johns Hopkins Medicine, who led the research. “Keeping them at particular locations within a synapse enables the brain to decide how and when to use them while thinking and processing information.”
In an effort to better understand the operation of these synaptic vesicles, Watanabe and his team designed a study that first focused on endocytosis, a process in which brain cells recycle synaptic vesicles after they are used for neuronal communication.
Already aware of intersectin’s general role in endocytosis and neuronal communication, the scientists genetically engineered mice to lack the gene that codes for intersectin. However, and somewhat to their surprise, Watanabe says removing the protein did not appear to halt endocytosis in brain cells.
The research team refocused their experiments, taking a closer look at the synaptic vesicles themselves.
Using a high-resolution fluorescence microscope to observe where intersectin is in a synapse, the researchers found it in between vesicles that are used for neuronal communication and those that are not, as if they are physically separating the two.
To further understand the role of intersectin at this location, they used an electron microscope to visualize synaptic vesicles in action across one billionth of a meter. In all the nerve cells from mice lacking this protein, the scientists say synaptic vesicles close to the membrane were absent from the release zone of the synapse, the place where the bubbles would discharge to nearby neurons.
“This suggested that intersectin regulates release, rather than recycling, of these vesicles at this location of the synapse,” says Watanabe.
Using a technique called zap and freeze microscopy, the scientists stimulated neurons in the brains of mice to capture the movement of synaptic vesicles on a millisecond timescale and at a nanometer resolution.
In normal mice, the scientists saw vesicles fusing with the brain cell membrane within a millisecond after stimulation. Then, new synaptic vesicles came and filled the vacated release sites of the synapse within about 15 milliseconds.
In two genetically engineered lines of mice, one lacking intersectin and another lacking the endophilin protein, which binds to intersectin, new vesicles could not be recruited to the vacated release sites. Similarly, vesicles within nerve cells of mice with mutations that blocked the interaction of these two proteins also slowed the local replenishment of synaptic vesicles that carry information from neuron to neuron.
“When information is processed in the brain, this replenishment process needs to happen in just a few milliseconds,” says Watanabe. “When you don’t have vesicles staged and ready to go at the release sites or the active zones, then neurotransmission cannot continue.”
In future research, the scientists say they aim to better understand how intersectin shuttles new synaptic vesicles to release sites.
Reference: Ogunmowo TH, Hoffmann C, Patel C, et al. Intersectin and endophilin condensates prime synaptic vesicles for release site replenishment. Nat Neurosci. 2025. doi: 10.1038/s41593-025-02002-4
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Mount Nyiragongo: The Volcano That’s Home To The World’s Largest Lava Lake
The world’s largest lava lake lies in the Democratic Republic of the Congo (DRC), nestled within Mount Nyiragongo. Stretching about 250 meters (820 feet) across at a depth of 600 meters (1,970 feet), it’s quite the hot tub of bubbling magma.
Part of the Virunga Mountains, it sits within the UNESCO World Heritage Site Virunga National Park, close to the city of Goma in eastern DRC. A chain of eight active volcanoes stretches across the landscape, experiencing eruptions at regular intervals every few years. Nyiragongo joins Nyamuragira in being the most active in Africa, the two being responsible for two-fifths of the historic eruptions on the continent, according to UNESCO.
The highly active pair are notable for the extreme fluidity of their basaltic lava flows, meaning eruptions are particularly dangerous as the lava can move at speeds of 60 kilometers per hour (37 miles per hour). This was demonstrated in the deadly 2002 eruption, which resulted in dozens of fatalities and displaced almost 500,000 DRC citizens as fissures along its southern slope leaked lava into the environment.
The reason why the lava is so dangerous is that it’s low in silica, and it’s the strong silicon-oxygen bonds that usually make lava thick and slow-moving. The difference is so significant that fast-flowing lavas were responsible for 90 percent of recorded lava-related deaths in the 20th century.
Deep inside Nyiragongo’s crater sits the largest lava lake in the world, filled with semi-permanent lava that empties every now and then in the event of catastrophic eruptions. Lava lakes are characterized by large quantities of molten lava, meaning it’s not solidified, and so puts on a smoky display in the day before lighting up at night with hues of orange you love to look at but don’t want to touch.
(Side bar: If you’ve ever wondered what lava would taste like, good news! You’re not alone. We put that exact question to the raised eyebrows of Scientist-in-Charge at the Yellowstone Volcano Observatory, Michael Poland, and University of Buffalo Associate Professor of Geology and expert on planetary volcanology, Tracy Gregg, in our first-ever issue of CURIOUS.)
Its high rate of activity, fast-moving lava, and proximity to humans make Nyiragongo one of the most dangerous volcanoes in the world. As such, scientists keep tabs on its movements for early warning signs of an eruption.
For all its ferocity, Mount Nyiragongo is also a breathtaking sight to behold, surrounded by lowland forests that are home to a variety of animals, including chimpanzees, monkeys, beautiful birds, and three-horned chameleons. If you’re up for a bit of hiking, you can take it all in along the Nyiragongo Volcano Trek.
This article first appeared in Issue 26 of our digital magazine CURIOUS. Subscribe and never miss an issue.
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‘I’d bet my house’ on treatment for Alzheimer’s
Jennifer WilsonBBC Scotland News
BBC
Prof David MacMillan says a treatment for Alzheimer’s could be available in five years A Nobel Prize-winning Scottish chemist has told the BBC he thinks drugs to treat Alzheimer’s disease will be available within five years.
Princeton University’s Prof David MacMillan, who is originally from North Lanarkshire, said “phenomenal things” are happening within medical research into neurological diseases.
“I would bet my house that within five years that we have marketed drugs for Alzheimer’s,” Prof MacMillan told the BBC’s Scotcast podcast.
“My father died of vascular dementia and my aunt had dementia. I think that’s such a horrible way to go.”
Getty Images
Prof MacMillan and Prof Benjamin List won the 2021 Nobel Prize in chemistry The Scottish scientist was awarded the 2021 Nobel Prize in Chemistry alongside Prof Benjamin List after developing a new way of building molecules.
Their work has led to developments in drugs for Alzheimer’s, cancer and heart disease.
Prof MacMillan, 57, said the award had made a massive impact on his life
“On a Tuesday morning, I was a chemist that nobody, including half my pals, had been interested in talking to,” he said.
“Then on the Wednesday, I was talking to like the New York Times and the Wall Street Journal.
“It was crazy – and I thought it would slow down but it just keeps on going.”
Prof MacMillan was awarded a half share of 10 million Swedish krona (£842,611).
He used it to set up The May and Billy MacMillan Foundation, named after his parents, where he funds Scottish students, providing educational opportunities to underprivileged young people.
He said education and learning was always good and gaining more experience was incredibly important.
It is something he knows about from his own life.
He grew up in New Stevenston, near Bellshill, and gained his undergraduate degree in chemistry at the University of Glasgow before moving to the US for postgraduate studies.
“I realised that education is your passport to the world,” he said.
After studying in California in the early 1990s, he moved to Harvard and the University of California at Berkeley before becoming a professor at Princeton in 2006.
He said working in the US had been great because its “research is the infrastructure that drives the health of the world”.
The possibilities of the people he was able to collaborate with had been “mind-boggling”, he said.
However, recent developments in US universities are causing concern, he said.
President Donald Trump and his Vice-President JD Vance have long railed against higher education institutions and they have been putting pressure on them over funding.
For the first time in 25 years, Prof Macmillan’s research group at Princeton has received no funding for the first seven months of the year from the US government.
He said: “Americans still care about the Nobel Prize.
“If that could happen to somebody like me, it could happen to anybody.”
The scientist said that academics were now the resistance as they try to deal with the politics of the current US administration “without selling their soul”.
Prof MacMillan said the cuts were “quite sinister” because it seemed like a way to control universities and the narrative by deciding who they can hire.
Higher education has become a hub for progressive thinking, which in his opinion, he said the Republicans don’t like.
“What they care the most about is retaining power,” he said.
David MacMillan
Sir David and Sir Alex Ferguson have become good friends Despite the pressure in the US, Prof MacMillan is not planning a return to Scotland just yet but he does regularly come back to see family – and some newfound friends.
He told the podcast he had become good friends with a Scottish legend who phoned to congratulate him after he won the Nobel prize.
Most people would ignore a call that said ‘No Caller ID’ but he answered to find Sir Alex Ferguson on the other end of the line.
The professor, who was himself knighted in 2022, said he thought one of his friends had been joking with him by pretending to be Sir Alex.
But he recognised that the voice sounded too similar to the former Manchester United football manager.
The two spoke about their common ground of growing up in Glasgow and the pair are now good friends who will be watching Manchester United play Chelsea together later in the year.
A portrait painted by Christabel Blackburn of Prof MacMilan Prof MacMillan not only sits next to Sir Alex at football games, the two will now feature together in the National Portrait Gallery of Scotland as the Scots chemist has had his portrait unveiled.
The Scots scientist said he was “blown away by it”.
The painting by Christabel Blackburn depicts the chemist sitting in his office with a white lab coat in the corner.
Prof MacMillan said it was actually a lab coat that he was “quite proud of” because it had been presented to him from his old school Bellshill Academy – which now sits in his office in Princeton University.
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eLife adds publishing agreements to its offering
eLife is offering open access agreements for research institutions “in support of a more equitable and sustainable system for scientific publishing”.
Under these agreements, known as “uncapped schemes”, corresponding authors affiliated with a partner organisation can publish an unlimited number of articles in eLife during a two-year term, with their organisation agreeing to cover a preset fee for that period. The publisher says uncapped schemes are a step towards a more equitable and sustainable publishing landscape, and typically help institutions support their researchers in publishing open access.
eLife’s first adopter of the agreement is the MIT Libraries, which runs until the end of April 2027 and applies to research submitted and sent for peer review through the eLife model. Launched in 2023, the publish–review–curate (PRC) approach used by eLife combines the speed and openness of preprints with the scrutiny offered by peer review.
Once an article has been selected for peer review, the authors can be sure that it will be published in eLife as a Reviewed Preprint. This is a new type of scientific publication that includes the article, feedback from the reviewers, and an eLife Assessment that summarises the significance of the findings being reported and the strength of the evidence. This approach emphasises the scientific content of individual articles rather than journal name.
Adding to these benefits, eLife’s says the uncapped scheme makes the system more equitable by moving away from a publication fee per published article and allowing unlimited publications for eligible authors, regardless of their ability to pay. It is also aimed at speeding up the process for authors, as they can select their institute during submission and thereby bypass the payment process.
eLife has also developed a centralised scheme to help transition away from traditional author fees for publication.
“We’ve garnered strong support from the research community for our efforts to reform science publishing and assessment,” says Fiona Hutton, eLife Head of Publishing. “With our uncapped and centralised schemes, we hope to partner with other like-minded organisations that support alternative approaches to publishing so we can move towards a better system for all, together.”
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Are you ready for Venus and Jupiter’s close approach this month? It’s going to be spectacular. Here’s how to see it
Venus is the brightest planet that can be seen from Earth. At its peak brightness, when 22% illuminated, Venus approaches mag. –5 – that’s so bright that it can cast shadows, if conditions allow.
Jupiter is bright too, able to reach mag. –2.94 under optimum conditions (coincidentally, that’s the same maximum brightness as Mars). Mercury isn’t far behind, able to attain a peak magnitude of –2.48.
Find out more about observing the planets in August and the August 2025 planet parade.
Planets Jupiter and Venus seen over L’Aquila, Italy, on 1 March 2023. Photo by Lorenzo Di Cola/NurPhoto via Getty Images Of course, catching all four near one another at peak brightness can’t actually happen, as Jupiter and Mars need to be opposite the Sun, a position that Mercury and Venus can never attain.
That’s not to say that a meeting between some of these worlds isn’t impressive.
And in August 2025, you’ll have a chance to take a look and see for yourself.
Key dates
Venus and Jupiter as they’ll appear on 1 August 2025. Credit: Pete Lawrence On 1 August, it’s just mag. –3.9 Venus and mag. –1.8 Jupiter that appear together in the dawn twilight.
They appear a little under 11° apart on this date, both being above the horizon just after 03:00 BST (02:00 UT).
But you’ll need to give them a bit more time to get to a decent altitude for viewing, say from around 04:00 BST (03:00 UT).
Over the course of the following mornings, the apparent gap between them closes due to Venus making a dash to the east, running under the stars that form the Gemini twin Castor’s foot.
Catch Venus early enough on 2 August, when the sky is still dark, and you might be able to see it 2.3° south of the open cluster M35. Binoculars will give the best view of this meeting.
On the morning of 7 August, the separation will be just 5°, Venus’s eastward rush far greater than the slow eastward crawl currently exhibited by Jupiter.
Seen from the UK, Venus and Jupiter are closest on 12 August 2025, separated by 52 arcminutes as sunrise approaches. Credit: Pete Lawrence Mercury is around too, but stubbornly refuses to be seen on this date, being too far entrenched in the Sun’s glare.
By 10 August, Jupiter and Venus will appear a little over 2° apart, now a striking pair for those who get up early enough to see them.
The closest approach occurs on the morning of 12 August, the planets being separated by 52 arcminutes.
Venus and Jupiter as they’ll appear on 12 August 2025. Credit: Pete Lawrence Telescopically, Venus is showing a 13-arcsecond disc, 78%-illuminated.
Jupiter appears 33 arcseconds across.
After 12 August, the pair start to separate once again, but another element is now ready to come into play.
Venus and Jupiter as they’ll appear on 20 August 2025. Credit: Pete Lawrence Mercury is now brightening, appearing as a star-like dot in the morning twilight further to the east of the main pair.
Between 19 and 22 August, the waxing crescent Moon skips along the line of planets, augmenting what is sure to be an already dynamic Solar System display.
Venus and Jupiter as they’ll appear on 21 August 2025. Credit: Pete Lawrence If you observe or photograph Venus and Jupiter in August 2025, we’d love to hear from you! Email us via contactus@skyatnightmagazine.com
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