Category: 7. Science

  • NSF NRAO Hosts SpectrumX Field Experiment at the Very Large Array

    NSF NRAO Hosts SpectrumX Field Experiment at the Very Large Array

    The U. S. National Science Foundation’s National Radio Astronomy Observatory (NSF NRAO) recently collaborated with NSF SpectrumX, the Spectrum Innovation Center, to host a large-scale spectrum research experiment at the U.S. National Science Foundation Very Large Array (NSF VLA) in New Mexico.

    This week-long effort, conducted in July 2025, brought together researchers, students, and experts from across academia, government, and industry to study spectrum usage in the 7.125 to 7.4 GHz band—frequencies of increasing importance to both science and emerging sixth-generation (6G) communications. Because of the unique sensitivity of the NSF VLA, the experiment provided a vital opportunity to explore how future spectrum allocations may affect radio astronomy and other passive scientific applications. Read the full release HERE. 

    About NRAO
    The National Radio Astronomy Observatory is a facility of the U.S. National Science Foundation, operated under cooperative agreement by Associated Universities, Inc.

    Contact:

    Corrina C. Jaramillo Feldman, Senior Public Information Officer
    National Radio Astronomy Observatory
    cfeldman@nrao.edu
    (505) 366-7267
    public.nrao.edu

    About SpectrumX

    SpectrumX is funded by the NSF as part of its Spectrum Innovation Initiative, under grant number AST 21-32700. SpectrumX is the world’s largest academic hub where all radio spectrum stakeholders can innovate, collaborate, and contribute to maximizing social welfare of this precious resource.

    To learn more about SpectrumX, please visit spectrumx.org.

    Contact:

    Stephanie Loney, Research Communications Specialist
    NSF SpectrumX / Notre Dame Research / University of Notre Dame
    sloney@nd.edu / 574.631.7804
    spectrumx.org

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  • Stressed Ice Generates Electricity, Researchers Find

    Stressed Ice Generates Electricity, Researchers Find

    Don’t mess with ice. When it’s stressed, ice can get seriously sparky.

    Scientists have discovered that ordinary ice—the same substance found in iced coffee or the frosty sprinkle on mountaintops—is imbued with remarkable electromechanical properties. Ice is flexoelectric, so when it’s bent, stretched, or twisted, it can generate electricity, according to a Nature Physics paper published August 27. What’s more, ice’s peculiar electric properties appear to change with temperature, leading researchers to wonder what else it’s hiding.

    The paper changes “how we view ice: from a passive material to an active material that may be at play for both fundamentals and applications,”
    Xin Wen, study lead author and a nanophysicist at Institut Catala de Nanociencia i Nanotecnologia in Spain, told Gizmodo in an email.

    A cold case in molecular chemistry

    An unsolved mystery in molecular chemistry is why the structure of ice prevents it from being piezoelectric. By piezoelectricity, scientists refer to the generation of an electric charge when mechanical stress changes a solid’s overall polarity, or electric dipole moment.

    The water molecules that make up an ice crystal are polarized. But when these individual molecules organize into a hexagonal crystal, the geometric arrangement randomly orients the dipoles of these water molecules. As a result, the final system can’t generate any piezoelectricity.

    However, it’s well known that ice can naturally generate electricity, an example being how lightning strikes emerge from the collisions between charged ice particles. Because ice doesn’t appear to be piezoelectric, scientists were confused as to how the ice particles became charged in the first place.

    “Despite the ongoing interest and large body of knowledge on ice, new phases and anomalous properties continue to be discovered,” the researchers noted in the paper, adding that this unsatisfactory knowledge gap suggests “our understanding of this ubiquitous material is incomplete.”

    A shockingly simple solution

    Fortunately, science likes to compartmentalize seemingly fundamental concepts. Electricity is no exception, so the researchers decided to investigate different “types” of electricity.

    Geometry posed the biggest obstacle to understanding ice’s observed electric behavior, so the team opted for flexoelectricity, which can “exist in materials of any symmetry,” they explained.

    For the experiment, they placed a slab of ice between two electrodes while simultaneously confirming that any electricity produced wasn’t piezoelectric. To their excitement, bending the ice slab created an electric charge, and at all temperatures, too. What they didn’t expect, however, was a thin ferroelectric layer that formed at the ice slab surface below -171.4 degrees Fahrenheit (-113 degrees Celsius).

    “This means that the ice surface can develop a natural electric polarization, which can be reversed when an external electric field is applied—similar to how the poles of a magnet can be flipped,” Wen explained in a statement.

    Surprisingly, “ice may have not just one way to generate electricity but two: ferroelectricity at very low temperatures and flexoelectricity at higher temperatures all the way to 0 [degrees C],” Wen added.

    The utility of stressed-out ice

    The finding is both useful and informative, the researchers said. First, the “flip” between flexoelectricity and ferroelectricity puts ice “on par with electroceramic materials such as titanium dioxide, which are currently used in advanced technologies like sensors and capacitors,” they noted.

    Perhaps more apparent is the finding’s connection to natural phenomena, namely thunderstorms. According to the paper, the electric potential generated from flexoelectricity in the experiment closely matched that of the energy produced by colliding ice particles. At the very least, it would make sense for flexoelectricity to be partly involved in how ice particles interact inside thunderclouds.

    “With this new knowledge of ice, we will revisit ice-related processes in nature to find if there is any other profound consequence of ice flexoelectricity that has been overlooked all the way,” Wen told Gizmodo.

    Both conclusions will need further scrutiny, the researchers admitted. Nevertheless, the findings offer illuminating new insight into something as common as ice—and demonstrate how much there’s still to be learned about our world.

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  • Ice melt is the main driver of Earth’s sea-level surge happening now

    Ice melt is the main driver of Earth’s sea-level surge happening now

    The water level of the Earth’s oceans does not increase by chance. Every millimeter has a cause. When sea levels rise, the reasons are buried in melting ice, warming seas, and the transfer of water from land to ocean.

    Scientists now treat global mean sea level as one of the clearest signals of climate change. And that signal has become louder in the past 30 years.

    Building 30-year record


    Researchers at Hong Kong Polytechnic University (PolyU) have built the first 30-year record of global ocean mass change.

    The study, led by Professor Jianli Chen and Dr. Yufeng Nie, used satellite laser ranging, or SLR, to track water added to the seas between 1993 and 2022.

    Before now, reliable mass records began only in 2002, with the GRACE mission.

    The results of the latest study, published in the Proceedings of the National Academy of Sciences, close that gap and strengthen confidence in how scientists monitor rising sea levels.

    Ice melt and sea-level rise

    Sea level rises for two main reasons. Warm water expands, and melting ice adds mass to the ocean. The PolyU record shows how much mass matters.

    Between 1993 and 2022, global sea level rose by about 90 millimeters (3.5 inches).

    Around 60 percent of that came from added ocean mass, not expansion. In the past two decades, the contribution from ice loss has accelerated, pushing the rate of rise from 3.2 to 3.6 millimeters (0.13 to 0.14 inches) per year.

    Satellites track sea-level rise

    SLR is not a new technology. It has been used for decades to measure satellite distances. But its data were once too coarse to track ocean mass.

    The PolyU team solved that by applying forward modeling, a method that corrects distortions along land-ocean boundaries and accounts for geocenter motion.

    The result is a continuous and reliable record that lines up with the GRACE observations, despite the older method’s limitations.

    The weight of melting ice

    Breaking down the numbers shows where the rise comes from. Greenland added about 0.60 millimeters (0,24 inches) of sea-level rise each year between 1993 and 2022. Glaciers contributed a similar amount. Antarctica added 0.40 millimeters (0.16 inches).

    Changes in land water storage, such as reservoirs and groundwater use, added about 0.32 millimeters (0.012 inches).

    Since the 2000s, Greenland has become the single largest source, while melting ice sheets and glaciers combined now account for about 85 percent of all ocean mass increase.

    The study also picked up short-term swings. Sea levels dipped during the 2010–2011 La Niña and rose sharply during the 2015–2016 El Niño event.

    GRACE captured these shifts with high precision, while SLR detected them more roughly. Even with noise, the agreement between the two systems builds trust in the results. The long-term signal remains unmistakable: ice melt drives today’s rising seas.

    The budget closes

    For years, scientists struggled to match observed sea-level rise with the sum of its causes. That gap created doubts.

    The PolyU study shows the budget now closes. The combined effects of warming water and ocean mass increase line up with altimetry observations almost perfectly.

    From 1993 to 2022, the numbers differ by less than 0.1 millimeters per year (0.0004 of an inch). That closure means researchers can now account for nearly every drop.

    Climate and sea-level rise

    “In recent decades, climate warming has led to accelerated land ice loss, which has played an increasingly dominant role in driving global sea-level rise,” said Professor Jianli Chen.

    “Our research enables the direct quantification of global ocean mass increase and provides a comprehensive assessment of its long-term impact on sea-level budget. This offers crucial data for validating coupled climate models used to project future sea-level rise scenarios,” added Prof. Chen.

    This point highlights the urgency of connecting observational science with climate models. Accurate data on ocean mass strengthens the ability to project how coastlines may change in decades to come.

    “The research showed that the ocean-mass changes derived from SLR analysis align well with the total sea-level changes observed by satellite altimeters, after accounting for the effect of ocean thermal expansion. This demonstrates that the traditional SLR technique can now serve as a novel and powerful tool for long-term climate change studies,” noted Dr. Yufeng Nie.

    What comes next

    The work proves SLR still has value. It cannot match the fine detail of GRACE, but it extends the record back another decade and cross-checks existing data.

    Improvements are possible. Adding other satellite systems and refining models could sharpen results even further. What matters most is the message: the oceans are rising faster, and melting ice is the main reason.

    Sea-level rise no longer hides behind uncertainty. The numbers tell the same story across methods. Thermal expansion is steady, but ice loss is climbing.

    The seas are rising, and they are rising faster than before. The message is clear, and it is one that humanity cannot afford to ignore.

    The study is published in the journal Proceedings of the National Academy of Sciences.

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  • NASA Spaceline Current Awareness List #1,164 29 August 2025 (Space Life Science Research Results)

    NASA Spaceline Current Awareness List #1,164 29 August 2025 (Space Life Science Research Results)

    The abstract in PubMed or at the publisher’s site is linked when available and will open in a new window.

  • McGregor HR, Hupfeld KE, Pasternak O, Beltran NE, De Dios YE, Bloomberg JJ, Wood SJ, Riascos RF, Reuter-Lorenz PA, Seidler RD.Crewmember demographic factors and their association with brain and ocular changes following spaceflight.npj Microgravity. 2025 Aug 28;11:59.PI: R.D. SeidlerNote: ISS results. This article may be obtained online without charge.

    Journal Impact Factor: 5.1

    Funding: “This study was supported by NASA grant #NNX11AR02G awarded to RDS, SJW, PARL, and JJB. HRM was supported by an NSERC postdoctoral fellowship, a Translational Research Institute for Space Health Postdoctoral Fellowship, and a NASA Human Research Program augmentation grant. KEH was supported by National Institute on Aging fellowships F99AG068440 and K00AG068440.”

  • Friedman MA, Zeineddine Y, Tuyambaze O, Elhawabri W, Al Shammary A, Stodieck L, Ferguson VL, Donahue H.Simulated microgravity accurately models long-duration spaceflight effects on bone and skeletal muscle in skeletally immature mice.Bone Rep. 2025 Sep;26:101871.PI: M.A. FriedmanNote: Hindlimb unloading study.

    Journal Impact Factor: 2.6

    Funding: “This work is supported by the Translational Research Institute for Space Health Postdoctoral Fellowship (NASA Cooperative Agreement NNX16AO69A), Center for the Advancement of Science in Space User Agreement UA-2019-888, and National Institutes of Health 3UM1TR004360-02S2.”

  • Lonner TL, Austin CR, Blake JS, Gupta P, Katz JM, Gopinath AR, Clark TK.Impact of sickness induced by centrifugation on tilt perception.Front Neurol. 2025 Aug 12;16:1628938.PI: T.K. ClarkNote: This article is part of Research Topic “Impact of Vestibular Dysfunction Studies on Space Flight Health Challenges” (https://genelab.nasa.gov). The Research Topic also includes articles from previous Current Awareness Lists #1,075 https://doi.org/10.3389/fneur.2023.1284029 and #1,139 https://doi.org/10.3389/fneur.2025.1556553. This article may be obtained online without charge.

    Journal Impact Factor: 2.8

    Funding: “This work was supported by the National Aeronautics and Space Administration Human Research Program under Grant No. 80NSSC23K0449.”

  • Hughes AM, Jenkins BE, Bauer LV, Kiss JZ.Performance and accuracy of the automated measurement software: Simple Online Automated Plant Phenomics (SOAPP).Gravit Space Res. 2025 Aug 7;13(1):51-64.PI: J.Z. KissNote: This article may be obtained online without charge.

    Journal Impact Factor: 2.0

    Funding: PI reports past NASA funding.

  • Johns S, Wiegman E, Bakshi A, Gilroy S.The cyclic nucleotide-gated channels CNGC2 and CNGC4 support systemic wound responses in Arabidopsis thaliana.Front Plant Sci. 2025 Aug 21;16:1545065.PI: S. GilroyNote: This article may be obtained online without charge.

    Journal Impact Factor: 4.8

    Funding: “The authors are grateful for funding for this work from NSF MCB2016177, NASA 80NSSC21K0577 and 80NSSC19K0126, and the Wisconsin Space Grant Consortium.”

  • Evans MA, Walsh K.Clonal hematopoiesis in cancer and cardiovascular disease: JACC: CardioOncology state-of-the-art review.JACC: CardioOncology. 2025 Aug;7(5):470-95.PI: K. WalshNote: This article may be obtained online without charge.

    Journal Impact Factor: 12.8

    Funding: “These studies were supported by National Institutes of Health grants AG073249 and AG086508, Department of Defense grant CA210887, and National Aeronautics and Space Administration grant 80NSSC21K0549 to Dr Walsh.”

  • Walsh RFL, Smith LT, Bisgay A, Stephenson AR, Goel N, Alloy LB.Sleep duration as a mediator of the association between caffeine intake and mood symptoms: An intensive longitudinal study of young adults with and without bipolar spectrum disorders.Chronobiology International. 2025 Aug 18;1-11. Online ahead of print.PI: N. GoelJournal Impact Factor: 1.7

    Funding: “This study was supported in part by the National Science Foundation’s Graduate Research Fellowship to Rachel Walsh and by National Institute of Mental Health R01 grants [MH077908, MH102310, and MH126911] to Lauren B. Alloy. Namni Goel was supported in part by National Aeronautics and Space Administration (NASA) grants [NNX14AN49G] and [80NSSC20K0243] and National Institutes of Health grant [R01DK117488].”

  • Bouvet P, Bevilacqua C, Ambekar Y, Antonacci G, Au J, Caponi S, Chagnon-Lessard S, Czarske J, Dehoux T, Fioretto D, Fu Y, Guck J, Hamann T, Heinemann D, Jähnke T, Jean-Ruel H, Kabakova I, Koski K, Koukourakis N, Krause D, La Cavera S, Landes T, Li J, Mahmodi H, Margueritat J, Mattarelli M, Monaghan M, Overby DR, Perez-Cota F, Pontecorvo E, Prevedel R, Ruocco G, Sandercock J, Scarcelli G, Scarponi F, Testi C, Török P, Vovard L, Weninger WJ, Yakovlev V, Yun S-H, Zhang J, Palombo F, Bilenca A, Elsayad K.Consensus statement on Brillouin light scattering microscopy of biological materials.Nat Photon. 2025 Jul 3;19(7):681-91.Note: This article may be obtained online without charge.

    Journal Impact Factor: 32.9

    Funding: “…support from NASA, BARDA, the NIH and USFDA under contract/agreement no. 80ARC023CA002.”

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  • Marsquakes reveal exactly how the Red Planet was formed

    Marsquakes reveal exactly how the Red Planet was formed

    Scientists have been curious for years about what is hidden beneath the surface of Mars. With its freezing temperatures, red dust, and dry valleys, the surface of the planet has received most of the attention. But something big is buried deep inside Mars’ mantle.

    Thanks to NASA’s Insight lander, we’re finally getting a clearer look below the surface. And what’s there is surprising: leftover chunks from ancient cosmic crashes are buried deep in the planet’s mantle.


    These rocky fragments aren’t small. Some are as wide as 2.5 miles (4 kilometers). They’re scattered across Mars’ interior like forgotten debris from the solar system’s wild early days.

    Mars got slammed – hard

    Giant space rocks – possibly even protoplanets – crashed into Mars some 4.5 billion years ago. They impacted hard enough to melt enormous chunks of the planet’s crust and mantle, and form vast oceans of molten rock.

    When those impacts occurred, they shattered the surface. They blasted rocky debris, including parts of the impactors, deep into the interior of the Red Planet.

    Unlike Earth, which constantly reshuffles its crust through plate tectonics, Mars’ crust is made of a single plate that has stayed mostly stable.

    That’s why those ancient impact scars haven’t been erased. The fragments are still down there, frozen in place like time capsules.

    “We’ve never seen the inside of a planet in such fine detail and clarity before,” said Constantinos Charalambous of Imperial College London, the paper’s lead author.

    “What we’re seeing is a mantle studded with ancient fragments. Their survival to this day tells us Mars’ mantle has evolved sluggishly over billions of years. On Earth, features like these may well have been largely erased.”

    Scientists believe giant impacts — like the one depicted in this artist’s concept — occurred on Mars 4.5 billion years ago, injecting debris from the impact deep into the planet’s mantle. NASA’s InSight lander detected this debris before the mission’s end in 2022. Credit: NASA/JPL-Caltech
    Scientists believe giant impacts – like the one depicted in this artist’s concept – occurred on Mars 4.5 billion years ago, injecting debris from the impact deep into the planet’s mantle. NASA’s InSight lander detected this debris before the mission’s end in 2022. Click image to enlarge. Credit: NASA/JPL-Caltech

    InSight sees into Mars’ mantle

    All of this comes from a mission called InSight, short for Interior Exploration using Seismic Investigations, Geodesy and Heat Transport. It was run by NASA’s Jet Propulsion Laboratory in Southern California and the lander arrived on Mars in 2018.

    InSight was the first lander to place a seismometer on Mars’ surface. That device was incredibly sensitive and recorded 1,319 marsquakes before the mission ended in 2022.

    Quakes send out waves that travel through the planet. As those waves move through different materials, they change speed and direction.

    Scientists can study how those waves behave to figure out what’s inside the planet, kind of like how doctors use ultrasound to see inside the human body.

    “We knew Mars was a time capsule bearing records of its early formation, but we didn’t anticipate just how clearly we’d be able to see with InSight,” said Tom Pike of Imperial College London, coauthor of the paper.

    What causes marsquakes?

    Marsquakes still happen, usually for two reasons. Some are caused when rocks crack under pressure and heat. Others are caused by meteoroids slamming into the surface.

    A study published earlier this year in Geophysical Research Letters showed that meteoroid impacts can create high-frequency seismic waves.

    These waves travel deep into the mantle, which is a thick layer of rock beneath the crust. The mantle can be nearly 960 miles (1,545 kilometers) thick, and reach temperatures as high as 2,732 °F (1,500 °C).

    Eight of the marsquakes recorded by InSight had strong, high-frequency signals that got noticeably scrambled and delayed.

    “When we first saw this in our quake data, we thought the slowdowns were happening in the Martian crust,” Pike said.

    “But then we noticed that the farther seismic waves travel through the mantle, the more these high-frequency signals were being delayed.”

    Buried lumps in Mars’ mantle

    Computer simulations helped scientists figure it out. Those delays only happened when the quake waves passed through small regions of the mantle that had a different composition from everything around them. These were the buried impact fragments.

    Some were massive. Others were smaller. All were mixed into the mantle, which Charalambous compared to “shattered glass – a few large shards with many smaller fragments.”

    That fits with what we already know: In the early solar system, planets like Mars got hit often and hard.

    Charalambous said the fact that these features are still visible “tells us Mars hasn’t undergone the vigorous churning that would have smoothed out these lumps.”

    A cutaway view of Mars in this artist’s concept (not to scale) reveals debris from ancient impacts scattered through the planet’s mantle. On the surface at left, a meteoroid impact sends seismic signals through the interior; at right is NASA’s InSight lander. Credit: NASA/JPL-Caltech
    A cutaway view of Mars in this artist’s concept (not to scale) reveals debris from ancient impacts scattered through the planet’s mantle. On the surface at left, a meteoroid impact sends seismic signals through the interior; at right is NASA’s InSight lander. Click image to enlarge. Credit: NASA/JPL-Caltech

    What other planets might be hiding

    This discovery doesn’t just help us understand Mars. It also gives clues about other rocky planets – especially ones that don’t have tectonic activity, like Venus and Mercury.

    If Mars is holding onto traces of ancient impacts deep in its mantle, maybe those planets are, too.

    Mars has always been a quiet planet on the surface. But now we know that, deep inside, it’s holding the scars of an ancient and violent past – and it hasn’t let them go.

    The study was published in the journal Science.

    Image credit: NASA/JPL-Caltech

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  • Platelets found to mop up DNA fragments and improve early cancer detection

    Platelets found to mop up DNA fragments and improve early cancer detection

    Platelets are probably best known for their role in blood clotting, making scabs and related, if less salubrious, contributions to heart attacks and strokes. But these tiny, saucer-shaped blood cells have other physiological duties as well, including surveillance for viral or bacterial infections, the recruitment of immune cells to the site of a suspected incursion and even the direct destruction of pathogens. Now, thanks to the findings of a Ludwig Cancer Research study, we can add to this rich portfolio an additional and critically important function.

    Researchers led by Ludwig Oxford’s Bethan Psaila and postdoc Lauren Murphy report in the current issue of Science that platelets may also help suppress systemic inflammation. Better yet, the way they do so can be readily harnessed to significantly improve the early and minimally invasive detection of cancer and the sensitivity of prenatal screening.

    While platelets do not have their own nuclei, we discovered that they act like sponges, mopping up the fragments of DNA that are released by dead and dying cells. Our bodies employ multiple mechanisms to clear these bits of DNA from the bloodstream, as they can provoke inflammatory and autoimmune disorders if they accumulate. Our findings suggest platelets play an important role in limiting the abundance of DNA fragments in plasma. Fascinatingly, we also discovered that they then release these pieces of DNA when they are activated, suggesting that platelets can deploy their DNA cargo in a manner that prevents nonspecific inflammation yet elicits targeted inflammatory responses where they’re needed, such as, say, at a site of injury.”


    Bethan Psaila, Ludwig Oxford

    Cell-free (cf) DNA can also include traces of circulating tumor cell-derived DNA (ctDNA). An increasingly sophisticated suite of technologies now exists to isolate and analyze ctDNA for the noninvasive detection of cancers and monitoring of responses to therapy. But ctDNA levels are very low, especially in the earliest stages of disease, when cancers are best detected. Its rarity reduces the sensitivity of cancer screening by such “liquid biopsies”.

    As it happens, the cfDNA collected for these diagnostics is currently isolated from blood plasma after all the blood cells, including platelets, have been discarded. The findings of this study suggest that a substantial proportion of cfDNA, including that derived from tumor cells, is contained within platelets, and this important source of information is therefore being missed.

    “We’ve demonstrated that platelets take up DNA fragments that bear the mutational signatures of cancer cells,” said Murphy. “This is true not only in patients with advanced cancer but, remarkably, also in people who have pre-cancerous polyps in their colon, suggesting that platelets may offer an additional and so far untapped reservoir of cfDNA that could significantly improve the sensitivity of liquid biopsies.”

    The finding that circulating platelets bear the genetic signatures of cancer has significant implications for cancer prevention.

    What prompted the researchers to look for DNA in cells that lack a nucleus?

    Platelets have a notable morphological quirk: they’re shot through, like sponges, with a network of membrane-lined channels called the open canalicular system. These channels allow them to release certain biomolecules essential to clotting and tissue repair upon activation and to pick up others, like viral RNA and DNA, as they circulate. Given the latter capability, Psaila hypothesized several years ago at a multi-institutional, cross-disciplinary brainstorming session organized by the philanthropy Cancer Research UK that platelets might also be picking up genomic cfDNA.

    In partnership with senior author Chris Gregory at the University of Edinburgh, Psaila prepared a pitch, winning a small award that allowed her to hire a research assistant, Murphy, to validate this hypothesis. A year later, the researchers had exciting data that helped Murphy secure a position in a PhD program and a major early detection project grant from Cancer Research UK.

    They and their colleagues, including Ludwig Oxford’s Benjamin Schuster-Böckler, whose lab conducted computational analysis for this study, showed that platelets indeed mop up human cfDNA in lab cultures and clinical samples. To prove that they weren’t just seeing residual DNA from megakaryocytes-nucleated cells from which platelets are derived-the researchers examined DNA from the platelets of pregnant women known to be carrying males. They report that they could predict the sex of the baby in every blood sample they analyzed by detecting fragments of the Y chromosome in the platelets, which could only have come from fetal cfDNA they’d mopped up in their travels.

    “Given their abundance, ease of isolation and tissue-wide perfusion, platelets are ideally positioned to serve as biosensors for genetic perturbations across tissues,” said Psaila.

    Future work in the lab will seek to clarify the role of platelets in the physiological management of cfDNA and the fate and consequences of DNA fragments released upon platelet activation.

    This study was funded by Ludwig Cancer Research, Cancer Research UK, the UK Medical Research Council, Rosetrees Trust, Kidani Memorial Trust and Yosemite.

    Bethan Psaila is an associate member of the Oxford Branch of the Ludwig Institute for Cancer Research and an associate professor in hematology at the University of Oxford.

    Source:

    Journal reference:

    Murphy, L., et al. (2025). Platelets sequester extracellular DNA, capturing tumor-derived and free fetal DNA. Science. doi.org/10.1126/science.adp3971

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  • Comment on: ‘Noncryopexy versus cryopexy treatment during scleral buckling: a systematic review and meta-analysis’

    We read with interest the systematic review and meta-analysis by Chen et al. [1] showing that similar outcomes were noted postoperatively no matter whether retinopexy was performed in combination with scleral buckling or not. The authors observed similar reattachment rate, final VA and complication rates between the two groups.

    The authors agree with the hypothesis that buckle placement is a permanent procedure and therefore its effect on retinal re-attachment is a permanent one. However, both clinical practice and literature have highlighted the fact that buckle removal may be required on several occasions for different indications [2,3,4]. Some common risk factors include exposed scleral buckle and infection, diplopia, patient discomfort or other ocular procedures [2,3,4]. While buckle removal may be a safe procedure if adequate retinopexy has been performed before, it is likely that buckle removal in non-retinopexy cases will result in retinal break re-opening and retinal re-detachment.

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  • Electrical stimulation reprograms macrophages to reduce inflammation

    Electrical stimulation reprograms macrophages to reduce inflammation

    Scientists from Trinity College Dublin have discovered that electrically stimulating “macrophages” – one of the immune systems key players – can “reprogram” them in such a way to reduce inflammation and encourage faster, more effective healing in disease and injury. 

    This breakthrough uncovers a potentially powerful new therapeutic option, with further work ongoing to delineate the specifics.

    Macrophages are a type of white blood cell with several high-profile roles in our immune system. They patrol around the body, surveying for bugs and viruses, as well as disposing of dead and damaged cells, and stimulating other immune cells – kicking them into gear when and where they are needed.

    However, their actions can also drive local inflammation in the body, which can sometimes get out of control and become problematic, causing more damage to the body than repair. This is present in lots of different diseases, highlighting the need to regulate macrophages for improved patient outcomes. 

    In the new study, just published in the international journal Cell Reports Physical Science, the Trinity team worked with human macrophages isolated from heathy donor blood samples provided via the Irish Blood Transfusion Board, St James’s Hospital. They stimulated these cells using a custom bioreactor to apply electrical currents and measured what happened.

    The scientists discovered that this stimulation caused a shift of macrophages into an anti-inflammatory state that supports faster tissue repair; a decrease in inflammatory marker (signalling) activity; an increase in expression of genes that promote the formation of new blood vessels (associated with tissue repair as new tissues form); and an increase in stem cell recruitment into wounds (also associated with tissue repair).

    We have known for a very long time that the immune system is vital for repairing damage in our body and that macrophages play a central role in fighting infection and guiding tissue repair.” 


    Dr. Sinead O’Rourke, Research Fellow in Trinity’s School of Biochemistry and Immunology, and first author of the research article

    “As a result, many scientists are exploring ways to ‘reprogram’ macrophages to encourage faster, more effective healing in disease and to limit the unwanted side-effects that come with overly aggressive inflammation. And while there is growing evidence that electrical stimulation may help control how different cells behave during wound healing, very little was known about how it affects human macrophages prior to this work.”

    “We are really excited by the findings. Not only does this study show for the first time that electrical stimulation can shift human macrophages to suppress inflammation, we have also demonstrated increased ability of macrophages to repair tissue, supporting electrical stimulation as an exciting new therapy to boost the body’s own repair processes in a huge range of different injury and disease situations.”

    The findings from the interdisciplinary team led by Trinity investigators, Professor Aisling Dunne (School of Biochemistry and Immunology) and Professor Michael Monaghan (School of Engineering) is especially significant given that this work was performed with human blood cells (showing its effectiveness for real patients), electrical stimulation is relatively safe and easy in the scheme of therapeutic options, and the outcomes should be applicable to a wide range of scenarios.

    Corresponding author Prof. Monaghan added: “Among the future steps are to explore more advanced regimes of electrical stimulation to generate more precise and prolonged effects on inflammatory cells and to explore new materials and modalities of delivering electric fields. This concept has yielded compelling effects in vitro and has huge potential in a wide range of inflammatory diseases.”

    Source:

    Journal reference:

    O’Rourke, S. A., et al. (2025). Electromodulation of human monocyte-derived macrophages drives a regenerative phenotype and impedes inflammation. Cell Reports Physical Science. doi.org/10.1016/j.xcrp.2025.102795

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  • Gold Stays Solid at 14 Times Its Melting Point During Physics Experiment

    Gold Stays Solid at 14 Times Its Melting Point During Physics Experiment

    SLAC National Accelerator Laboratory and University of Nevada, Reno scientists have debunked a 40-year-old theory by heating solid gold to 14 times its normal melting point without melting it!

    The scientists achieved this feat and rewrote the rules of high-temperature physics using a combination of ultrafast lasers and X-rays.

    Understanding Entropy Catastrophe

    For nearly 40 years, physicists have believed there is a hard limit to how hot a solid can get without spontaneously breaking apart. 

    Known as the “entropy catastrophe,” this theory holds that once a material reaches around three times its melting point, the increased entropy overwhelms its structure, causing it to liquefy.

    Hotter Than the Sun

    SLAC’s recent experiment, however, challenges this long-standing belief.

    The scientists hit a wafer-thin gold film with a 45-femtosecond laser pulse. They followed it up with a flash from SLAC’s 2-mile-long Linac Coherent Light Source X-ray laser that functioned as an atomic thermometer.

    While gold’s normal melting point is 1,337 kelvins (1,947°F), the scientists, by observing how the X-rays scattered off the vibrating gold atoms, calculated a mind-boggling 19,000 kelvins (33,740°F) — hotter than even the Sun’s surface (9,900°F)!

    And the best part? By heating the material so fast, the atoms didn’t have time to reorganize into a liquid structure. SLAC’s process basically outran the material’s natural melting behavior.

    The Future of Thermodynamics

    Ask any particle scientist, and they’ll tell you how tough it is to measure and understand extreme states of matter, such as those found in the cores of gas giants like Jupiter or inside fusion reactors on Earth. Even if they do, it would be plagued by large error bars.

    By shattering the temperature barrier, the SLAC-Nevada team has now shown it is possible to probe the inner temperatures within ultra-hot systems accurately.

    Image credit: artshock/Shutterstock

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  • Were humans banished by aliens? Earth might be trapped inside a giant space bubble, discover scientists

    Were humans banished by aliens? Earth might be trapped inside a giant space bubble, discover scientists

    For decades, humans have imagined that the universe might be filled with intelligent life. Yet despite billions of stars and galaxies, we have found no clear evidence of aliens. Now, scientists suggest a possible reason: Earth may be located in an enormous cosmic void—a vast, sparsely populated region of space. If true, our planet could be unusually isolated from the denser regions of the universe, giving the appearance that humanity is alone or even “ostracized” in the cosmic landscape.

    This theory, presented at the Royal Astronomical Society’s National Astronomy Meeting, has been led by Dr. Indranil Banik of the University of Portsmouth. The discovery could have far-reaching implications for our understanding of the universe’s structure and expansion.

    Dr. Banik’s team explained that the local void, also referred to as an underdensity, could be roughly one billion light-years wide and about 20% less dense than the average universe. This sparsity of matter would affect how we perceive galaxy movements, potentially making it appear that the universe is expanding faster than it actually is.

    Possible Solution to the Hubble Tension

    The idea of a local cosmic void provides a potential explanation for the long-standing Hubble Tension, which arises from discrepancies in measuring the universe’s expansion rate. Observations of distant galaxies suggest a slower expansion, while local measurements indicate a faster rate. According to Dr. Banik, if the Milky Way is located inside a vast void, gravitational effects from denser surrounding regions would pull matter outward, making local velocities seem larger.

    “This model, based on two decades of baryon acoustic oscillation data, is significantly more likely than a void-free model,” Dr. Banik said, highlighting the consistency of his team’s findings with patterns left from the Big Bang.

    Implications for Cosmology

    If confirmed, the local void theory challenges the assumption that the universe is uniform on large scales. It would also have consequences for predictions about the universe’s future, including the timing of the so-called “heat death,” when energy is evenly distributed and no significant cosmic activity occurs.While the idea of humans living in a cosmic void is still debated, Banik’s research strengthens the possibility that our region of the universe may be lonelier than previously thought. By analyzing oscillations caused by the early universe, his team has provided evidence that supports the existence of this massive void.

    Life in the Void

    Living in a cosmic void could have indirect implications for humanity, as it affects how we perceive the universe around us. Although the void does not directly indicate alien activity or ostracization, it does suggest that our cosmic neighborhood is isolated compared to denser regions of the universe.

    Further research, including comparisons with supernova data, will be necessary to fully validate this theory and understand its consequences for cosmology. For now, Earth’s place in a giant cosmic void remains a compelling possibility that may reshape how scientists view the universe.

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