Category: 7. Science

  • How tiny fossils are leading to smarter robots

    How tiny fossils are leading to smarter robots

    image: 

    Researchers have demonstrated a technique that geometrically models organic objects and creates photorealistic, three-dimensional (3D) images of those objects. These mathematically precise images can be used to engineer robotic systems capable of identifying and sorting these complex shapes autonomously. The technique was created to improve robotic systems that sort and identify microscopic marine fossils (shown here) used in climate research, but could serve as a blueprint for applications in a range of other fields.


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    Credit: Sanjana Banerjee, NC State University

    Researchers have demonstrated a technique that geometrically models organic objects and creates photorealistic, three-dimensional (3D) images of those objects. These mathematically precise images can be used to engineer robotic systems capable of identifying and sorting these complex shapes autonomously.

    The technique was created to improve robotic systems that sort and identify microscopic marine fossils used in climate research, but could serve as a blueprint for applications in a range of other fields.

    “We demonstrated the functionality of this technique in two ways: in a robotic system for 3D imaging of these microscopic marine fossils and in a robotic system for identification of the fossils,” says Edgar Lobaton, co-author of a paper on the work and a professor of electrical and computer engineering at North Carolina State University. “And identifying these fossils is very challenging, which is what led us to this work in the first place.”

    At issue are foraminifera, or forams, which have been prevalent in Earth’s oceans for more than 100 million years. Forams are protists, neither plant nor animal, and when they die, they leave behind their tiny shells. These shells give scientists insights into the characteristics of the oceans as they existed when the forams were alive. For example, different types of foram species thrive in different kinds of ocean environments, and chemical measurements can tell scientists about everything from the ocean’s chemistry to its temperature when the shell was being formed.

    However, evaluating foram shells and fossils is both tedious and time consuming – imagine sorting through hundreds of similarly shaped objects that are less than a millimeter wide. This is why paleontology researchers want to automate the process. And the nature of the challenge caught the interest of Lobaton.

    “We had already developed a fully functional robotic system for identifying and sorting forams, called Forabot,” Lobaton says. “And creating Forabot taught us that the most time-consuming aspect of the process is fine-tuning the hardware and how it is laid out. What size should each component be? What is the best configuration of components? There are a million variations you may want to tweak. The work we’re sharing here was developed specifically to address that challenge, because we wanted to find a more efficient way to improve Forabot.”

    By capturing 3D facsimiles of these fossils with incredible precision, the researchers can use those facsimiles in simulations of the robotic system.

    “You can make adjustments in the simulation far more easily than when working with actual hardware,” Lobaton says. “And once you have optimized the configuration of the system in the simulation, the process of fine-tuning the hardware in the real world is vastly easier – you already know how it should be set up.”

    For this work, the researchers modified a mathematical model so that it can produce detailed 3D facsimiles of the fossils. Lobaton’s team then worked with a paleontologist to ensure the facsimiles corresponded to the characteristics of seven representative species of foraminifera.

    The researchers then turned to a simulation of Forabot. Using the newly captured 3D facsimiles to explore modifications to Forabot’s system, the researchers were able to improve its accuracy from 82% to 89% – without having to go through the time-consuming process of repeatedly reconfiguring the hardware in their lab.

    “Using our synthetic dataset, we were able to test how state-of-the-art AI models can reconstruct 3D shapes from just a sparse set of 2D images,” says Sanjana Banerjee, corresponding author of the paper and a Ph.D. student at NC State. “These simulations helped us understand the best imaging conditions and are now guiding the development of a new robotic system focused on 3D reconstruction – an essential step toward further automating the identification of these microfossils.

    “Our work provides a strong foundation for studying the growth and morphology of a wide range of foraminifera species,” Banerjee says. “It also tackles major challenges in micropaleontology, such as limited data availability and accurate shape recovery.”

    “More broadly, the approach we took here could be used to develop or optimize any robotic system that identifies or sorts objects with complex shapes,” Lobaton says. “Potential use cases include microbe and pathogen isolation at the microscopic scale and sorting of agricultural produce at a larger scale.”

    The researchers have made the code base used in this work open source, so other researchers can make use of it. That can be found at: https://github.com/ARoS-NCSU/Forams-3DGeneration.

    The paper, “Foram3D: A Pipeline for 3D Synthetic Data Generation and Rendering of Foraminifera for Image Analysis and Reconstruction,” is published open access in the journal Marine Micropaleontology. The paper was co-authored by Turner Richmond, a former Ph.D. student at NC State; Michael Daniele, an associate professor of electrical and computer engineering at NC State; and Thomas Marchitto, a professor of geological sciences at the University of Colorado, Boulder.

    This work was done with support from the National Science Foundation under grant 1829930.


    Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.

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  • Volatile Enrichment In Low-mass Planets: Signatures Of Past Planetary Disruption?

    Volatile Enrichment In Low-mass Planets: Signatures Of Past Planetary Disruption?

    Time evolution of the gas disk and planetary envelopes after the tidal disruption of a Jupiter-like planet. – Disc surface density evolution for the 10 M⊕ case; circles indicate the closer VEP. — astro-ph.EP

    Context: Tidal disruption and engulfment events around main-sequence stars, such as the luminous red nova ZTF SLRN-2020 (a candidate planetary-engulfment event), reveal the destruction of close-in giant planets. While current observations focus on stellar accretion and inner dust emission, the fate of the volatile-rich material expelled during disruption remains poorly understood.

    Aims: We investigate whether the H/He-rich gas expelled from the disrupted planet’s envelope and atmosphere can escape the inner system and be gravitationally captured by an outer low-mass planet (a volatile-enriched planet, or VEP), potentially forming a transient atmosphere and producing detectable volatile contamination.

    Methods: We model the outward diffusion of gas from a tidally stripped giant using two-dimensional hydrodynamical simulations with FARGO3D, complemented by analytical estimates of volatile observability and atmospheric escape. We assess the efficiency of gas capture by outer planets and the survival timescales of the resulting secondary atmospheres under high-energy stellar irradiation.

    Results: Our simulations show that volatile-rich gas can form a VEP. The resulting envelopes can contain between 1e-10 and 1e-6 Earth masses, up to the mass of Earth’s atmosphere, for Earth-like planets, yielding transit depths of tens to several hundred ppm. Such signatures may persist for 1 to 100 million years, depending on planetary mass, orbit, and stellar activity.

    Conclusions: This scenario offers a viable pathway to form volatile-rich atmospheres in evolved low-mass planets. When accompanied by dynamical signatures such as eccentric orbits, these chemical anomalies may trace past planetary disruption. This framework may help interpret the atmospheric and orbital properties of systems like TOI-421b and WASP-107b, shedding new light on the late-stage evolution of planetary systems.

    Mario Sucerquia, Matías Montesinos, Ana María Agudelo, Nicolás Cuello

    Comments: Accepted for publication in Astronomy & Astrophysics. Comments welcome
    Subjects: Earth and Planetary Astrophysics (astro-ph.EP)
    Cite as: arXiv:2507.11693 [astro-ph.EP] (or arXiv:2507.11693v1 [astro-ph.EP] for this version)
    https://doi.org/10.48550/arXiv.2507.11693
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    Submission history
    From: Mario Sucerquia Dr
    [v1] Tue, 15 Jul 2025 19:48:36 UTC (4,518 KB)
    https://arxiv.org/abs/2507.11693

    Astrobiology, Astrochemistry, Astrogeology,

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  • Columbia’s CERN Breakthrough: Immortal Electronics

    Columbia’s CERN Breakthrough: Immortal Electronics

    The Large Hadron Collider (LHC) is tough on electronics. Situated inside a 17-mile-long tunnel that runs in a circle under the border between Switzerland and France, this massive scientific instrument accelerates particles close to the speed of light before smashing them together. The collisions yield tiny maelstroms of particles and energy that hint at answers to fundamental questions about the building blocks of matter.

    Those collisions produce an enormous amount of data — and enough radiation to scramble the bits and logic inside almost any piece of electronic equipment.

    That presents a challenge to CERN’s physicists as they attempt to probe deeper into the mysteries of the Higgs boson and other fundamental particles. Off-the-shelf components simply can’t survive the harsh conditions inside the accelerator, and the market for radiation-resistant circuits is too small to entice investment from commercial chip manufacturers.

    “Industry just couldn’t justify the effort, so academia had to step in,” according to Peter Kinget, the Bernard J. Lechner Professor of Electrical Engineering at Columbia Engineering. “The next discoveries made with the LHC will be triggered by one Columbia chip and measured by another.”

    Kinget leads the team that designed specialized silicon chips that collect data in one of the harshest and most important environments in particle physics. Their most recent paper describing this project was published July 1 in the IEEE Open Journal of the Solid-State Circuits Society.

    “These sort of collaborations between physicists and engineers are very important to advancing our ability to explore fundamental questions about the universe,” according to John Parsons, professor of physics at Columbia University and leader of the Columbia team working on the ATLAS detector, one of the LHC’s massive instruments. “Developing state-of-the-art instrumentation is crucial to our success.”

    Circuits that resist radiation

    The devices the team designed are called analog-to-digital converters, or ADCs. Their task is capturing electrical signals produced by particle collisions inside CERN’s detectors and translating them into digital data that researchers can analyze.

    In the ATLAS detector, the electrical pulses generated by particle collisions are measured using a device called a liquid argon calorimeter. This enormous vat of ultra-cold argon captures an electronic trace of every particle that passes through. Columbia’s ADC chips convert these delicate analog signals into precise digital measurements, capturing details that no existing component could reliably record.

    “We tested standard, commercial components, and they just died. The radiation was too intense,” says Rui (Ray) Xu, a Columbia Engineering PhD student who has worked on the project since he was an undergraduate at the University of Texas. “We realized that if we wanted something that worked, we’d have to design it ourselves.”

    Designing “high-accuracy” reliability

    Instead of creating entirely new manufacturing methods, the team used commercial semiconductor processes validated by CERN for radiation resistance and applied innovative circuit-level techniques. They carefully chose and sized components and arranged circuit architectures and layouts to minimize radiation damage and built digital systems that automatically detect and correct errors in real time. Their resulting design is resilient enough to withstand the unusually severe conditions at LHC for more than a decade.

    Two Columbia-designed ADC chips are expected to be integrated into the ATLAS experiment’s upgraded electronics. The first, called the trigger ADC, is already operating at CERN. This chip, initially described in 2017 and validated in 2022, enables the trigger system to filter about a billion collisions each second and to instantly select only the most scientifically promising events to record. It serves as a digital gatekeeper deciding what merits deeper investigation.

    The second chip, the data acquisition ADC, recently passed its final tests and is now in full production. The chip, which was described in an IEEE paper earlier this year, will be installed as part of the next LHC upgrade. It will very precisely digitize the selected signals, enabling physicists to explore phenomena like the Higgs boson, whose discovery at CERN made headlines in 2012 and led to the Nobel Prize in physics in 2013, but whose exact properties still hold mysteries.

    Both chips represent the kind of direct collaboration between fundamental physicists and engineers.

    “The opportunity as an engineer to contribute so directly to fundamental science, is what makes this project special,” Xu said.

    It further created opportunities to collaborate across multiple institutions. The chips were designed by electrical engineers at Columbia and at the University of Texas, Austin, in close collaboration with physicists at Columbia’s Nevis Laboratories and the University of Texas, Austin.

    Funded by the National Science Foundation and the Department of Energy, Columbia’s chips play a central role in a broader international collaboration coordinated in part by Columbia’s Nevis Laboratories. As research at CERN advances, Columbia-designed components will contribute to data acquisition systems that support physicists in analysing phenomena beyond the current limits of knowledge.

    /Public Release. This material from the originating organization/author(s) might be of the point-in-time nature, and edited for clarity, style and length. Mirage.News does not take institutional positions or sides, and all views, positions, and conclusions expressed herein are solely those of the author(s).View in full here.

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  • Impact-driven Oxidation Of Organics Explains Chondrite Shock Metamorphism Dichotomy

    Impact-driven Oxidation Of Organics Explains Chondrite Shock Metamorphism Dichotomy

    The number fraction of ordinary (NC, red thick) and carbonaceous (CC, blue thin) chondrites as a function of shock degree. The data are taken from the previous studies3,4. The corresponding approximate shock pressure of each shock degree is also shown on the top x-axis. — Nature Communications via PubMed

    Shocked meteorites can be used to probe the dynamics of the early Solar system. Carbonaceous chondrites are less shocked than ordinary chondrites, regardless of the degree of aqueous alteration.

    Here, we show that this shock metamorphic dichotomy is a consequence of impact-driven oxidation of organics that are abundant in carbonaceous but not ordinary chondrites. Impact experiments at 3–7 km s−1 using analogs of chondrite matrices reveal evidence of local heating in the matrix up to ~2000 K.

    Impacts on carbonaceous asteroids cause explosive release of CO and/or CO2, which can efficiently remove evidence of shock. We show that highly shocked materials are lost to space from typical-sized chondrite parent bodies (~100 km in diameter), but are retained on the largest known carbonaceous asteroid, namely, (1) Ceres, due to its stronger gravity.

    Ceres’ surface is thus a witness plate for the ancient impact environment of carbonaceous chondrite parent bodies.

    Impact-driven oxidation of organics explains chondrite shock metamorphism dichotomy, Nature Communications via PubMed

    Astrobiology, Astrogeology, Astrochemistry,

    Explorers Club Fellow, ex-NASA Space Station Payload manager/space biologist, Away Teams, Journalist, Lapsed climber, Synaesthete, Na’Vi-Jedi-Freman-Buddhist-mix, ASL, Devon Island and Everest Base Camp veteran, (he/him) 🖖🏻

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  • NSF reinvests in Molecule Maker Lab Institute, AI tools to solve chemistry’s challenges – News Bureau

    CHAMPAIGN, Ill. — With a new five-year, $15 million award, the U.S. National Science Foundation has renewed its support of the Molecule Maker Lab Institute, a research collaboration focused on developing artificial intelligence tools for quick, accessible discovery and synthesis of molecules for applications in medicine, energy, industry and more.

    Headquartered at the University of Illinois Urbana-Champaign, with partners at Pennsylvania State University and the Georgia Institute of Technology, the NSF MMLI was first established as a National Artificial Intelligence Research Institute in 2020. Huimin Zhao, a professor of chemical and biomolecular engineering at the U. of I., directs the NSF MMLI.

     “Functional molecules such as drugs, chemicals, enzymes and materials play a critical role in addressing many grand challenges facing society today. However, the process of discovering and manufacturing such molecules has remained slow, expensive, and highly specialist-dependent. We have developed AI tools and generalizable, automated molecule-making systems that can overcome this challenge and enable the rapid discovery and synthesis of more functional molecules that benefit society,” said Zhao, who also is affiliated with the Carl R. Woese Institute for Genomic Biology at the U. of I.

    In its first five years, the NSF MMLI has made advances in developing AI models, such as those used to predict the function of molecules based on their structures and those that suggest how to improve a molecule’s performance. The Institute also integrates those models with automated molecule-building systems and user-friendly interfaces to make the AI-driven solutions accessible even to researchers who are not chemists or biochemists. The work performed through the NSF MMLI has resulted in 166 journal and conference papers, 11 patent disclosures — including six that have been licensed — and two start-up companies.

    “Key accomplishments include the creation of AlphaSynthesis, an AI-powered platform that helps researchers plan and execute chemical synthesis, and the advancement of closed-loop systems that automate molecule development using real-time data and AI feedback. These tools have not only improved research efficiency but also led to new chemical discoveries,” NSF said in its award description.

    Over the next five years, the NSF MMLI plans to continue developing foundational AI agents for discovery and synthesis of functional molecules, as well as advancing AI-enabled discovery and development of catalysts, drugs and materials. In addition, the NSF MMLI will refine and scale up the innovative education and workforce development tools and programs that were developed in its first five years, such as the Digital Molecule Maker and Lab 217 Escape Room.

    “We are most excited about the next-generation AI tools that we will develop in this next chapter for molecular discovery and synthesis,” Zhao said. “We plan to develop a large language model for modular chemistry, AI agents with critical thinking capabilities and generative AI models for catalyst discovery. These AI tools should greatly accelerate the process of discovering and synthesizing functional molecules that benefit society.”

    Visit NSF News to read more about the 2025 National Artificial Intelligence Research Institutes awards.

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  • Internet Starlink satellites aren’t just messing up visible light images of the universe, they’re unintentionally interfering with radio astronomy as well

    Internet Starlink satellites aren’t just messing up visible light images of the universe, they’re unintentionally interfering with radio astronomy as well

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    Credit: Andrew Kravchenko/Bloomberg via Getty Images

    Over the decades, astronomers have faced the increasingly tough problem of satellites appearing in their view of the universe. The rapid growth of Starlink, SpaceX’s web-from-space system, isn’t just impacting countless pictures using visible light but also those in other parts of the spectrum. A recent study of 76 million images shows that the satellites are affecting the work of radio astronomers, even at frequencies that the satellites don’t transmit at.

    Take a photograph of the night sky, far away from any urban lights, and you stand a good chance of capturing the telltale streak of a satellite passing overhead. For any ground-based telescope capturing the faint photons of visible light from distant stars, it’s an unavoidable problem because the satellites will always reflect the Sun’s light.

    When it comes to observing space in the radio spectrum, though, it should be far less of a problem because satellite companies are forbidden to transmit in specific frequency windows. However, a study by Curtin University in Australia (via Space) shows that SpaceX’s Starlink satellites are “significantly interfering with radio astronomy observations, potentially impacting discovery and research”.

    Over four months, the research team amassed a total of 76 million radio wave images from a prototype section of the Square Kilometre Array observatory and upon analysis of the data, discovered that “[i]n some datasets … up to 30 per cent of our images showed interference from a Starlink satellite.”

    To make matters worse, the Starlink satellites were emitting signals in radio bands that they shouldn’t be. “Some satellites were detected emitting in bands where no signals are supposed to be present at all, such as the 703 satellites we identified at 150.8 MHz, which is meant to be protected for radio astronomy,” said study lead Dylan Grigg.

    A photograph of the SKA-Low radio wave observatory in Australia.

    Credit: SKAO

    “Because they may come from components like onboard electronics and they’re not part of an intentional signal, astronomers can’t easily predict them or filter them out.”

    Professor Steven Tingay, a co-author of the research paper, points out that SpaceX isn’t doing anything nefarious or the like. “It is important to note that Starlink is not violating current regulations, so is doing nothing wrong. Discussions we have had with SpaceX on the topic have been constructive.”

    Starlink isn’t the only satellite-based internet service provider, nor is it the only satellite company routinely launching new devices into low Earth orbit, but few companies (if any) are launching on the same scale as SpaceX. Grigg notes that during the study period, a total of 477 Starlink satellites were sent into orbit, and another study has shown that the newest Starlink models create 32 times more radio interference than previous designs.

    The number of electronic devices whizzing around our planet, transmitting within the permitted windows of the radio spectrum, is well over 10,000, and a significant portion of them are almost certainly going to be unintentionally emitting signals outside of the regulated zones.

    As Professor Tingay says, “current International Telecommunication Union regulations focus on intentional transmissions and do not cover this type of unintended emission. We hope this study adds support for international efforts to update policies that regulate the impact of this technology on radio astronomy research, that are currently underway.”

    Future launches may well have structures in place to greatly minimise, or even remove, the problem, but the thousands of satellites already in orbit will continue to be a problem for radio astronomers. The incredible benefits of space-based internet and global communications are plain for all to see, though too much so in the field of space research.

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  • NASA Wants To Drop Helicopter Drones On Mars To Scout For Manned Landing Sites

    NASA Wants To Drop Helicopter Drones On Mars To Scout For Manned Landing Sites

    In 2021, NASA’s Jet Propulsion Lab successfully launched the first powered flight on another planet with the Ingenuity drone helicopter, co-developed with AeroVironment, Inc. Now, the two are proposing to do it again, with one big change: They want to launch not one, but six new helicopters, and what’s more, they want to launch them as they’re descending from Mars orbit. Why bother with this pesky “ground” you speak of? Much cheaper to lift off when you’re already in the air.

    The mission is called Skyfall, which I guess no one told them was also the name of a James Bond movie. The idea is for a capsule to drop down towards the Martian surface, open up before it impacts, and out will fly the six helicopters. Each drone will then fly a different route, using cameras and radar to scan what’s underneath the surface. This will hopefully detect water, ice, or other resources that would make for a good landing site for an eventual manned mission to the red planet.

    It’s even possible that this process could “advance the nation’s quest to discover whether Mars was ever habitable.” Could a robot helicopter dropped from space find aliens on another planet? Probably not, but also, please yes.

    Read more: Here’s Every Car Company Volkswagen Owns Right Now

    The Importance Of Ingenuity

    When it first lifted off from Martian soil, Ingenuity only hoped to traverse 980 feet over the span of a few weeks. Instead, the plucky American aviator covered 10.5 miles over three years. It did finally crash in January 2024, during which it suffered rotor damage too severe to ever get it to fly again. While the cause of the crash remains unknown (kind of hard to do an investigation on Mars), Ingenuity soldiers on, dutifully serving as a static weather station now.

    I’d say that was a pretty successful mission, all things considered. Clearly NASA agrees, since the Skyfall mission is effectively a major expansion of Ingenuity; the new helicopter drones will be upgraded versions of that design, made by the same public-private partners, JPL and AeroVision respectively.

    Exactly how public vs how private may be shifting, however. AeroVision says that it will be taking on some of the work that JPL originally did “commercializing” Mars drones this time around. That sounds in line with the Trump administration’s push to move traditionally government-run operations, like retrieving astronauts, to corporations instead. NASA is also under threat of crippling proposed budget cuts, so it might not even be able to do the work it used to do.

    I, for one, think the Martian aliens will welcome their new American corporate overlords. Either way, Skyfall won’t be lifting off of Earth’s soil until at least 2028. If all goes well, air traffic will be getting pretty thick underneath red skies by the end of the decade.

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    Read the original article on Jalopnik.

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  • 400-million-year-old fish exposes big mistake in how we understood evolution

    400-million-year-old fish exposes big mistake in how we understood evolution

    The coelacanth is known as a “living fossil” because its anatomy has changed little in the last 65 million years. Despite being one of the most studied fish in history, it continues to reveal new information that could transform our understanding of vertebrate evolution. This is revealed in a study published in the journal Science Advances by researchers from the University of São Paulo (USP) in Brazil and the Smithsonian Institution in the United States.

    Upon re-examining the cranial musculature of the African coelacanth (Latimeria chalumnae), the authors discovered that only 13% of the previously identified evolutionary muscle novelties for the largest vertebrate lineages were accurate. The study also identified nine new evolutionary transformations related to innovations in feeding and respiration in these groups.

    “Ultimately, it’s even more similar to cartilaginous fish [sharks, rays, and chimaeras] and tetrapods [birds, mammals, amphibians, and reptiles] than previously thought. And even more distinct from ray-finned fish, which make up about half of living vertebrates,” says Aléssio Datovo, a professor at the Museum of Zoology (MZ) at USP supported by FAPESP, who led the study.

    Among the evolutionary novelties erroneously identified as present in coelacanths are muscles responsible for actively expanding the buccopharyngeal cavity, which extends from the mouth to the pharynx. This set of muscles is directly related to food capture and respiration. However, the study showed that these supposed muscles in coelacanths were actually ligaments, which are structures incapable of contraction.

    Ray-finned fish (actinopterygii) and lobe-finned fish (sarcopterygii) diverged from a common ancestor approximately 420 million years ago. The sarcopterygii include fish such as coelacanths and lungfish, as well as all other tetrapods, because they evolved from an aquatic ancestor. These include mammals, birds, reptiles, and amphibians.

    In ray-finned fish, such as aquarium carp, it is easy to see how the mouth moves to suck in food. This ability gave actinopterygii a significant evolutionary advantage; today, they comprise about half of all living vertebrates.

    This is a fundamental difference from other fish, such as coelacanths and sharks, which primarily feed by biting their prey.

    “In previous studies, it was assumed that this set of muscles that would give greater suction capacity was also present in coelacanths and, therefore, would have evolved in the common ancestor of bony vertebrates, which we now show isn’t true. This only appeared at least 30 million years later, in the common ancestor of living ray-finned fish,” points out Datovo.

    Behind the scenes

    Coelacanths are extremely rare fish that live about 300 meters below the surface of the water and spend their days in underwater caves.

    One reason they have changed so little since the extinction of the dinosaurs is that they have few predators and live in a relatively protected environment. This has resulted in slow changes to their genome, as shown by a 2013 study published in the journal Nature.

    Coelacanths were first known only from fossils from about 400 million years ago. It was not until 1938 that a living animal was discovered, much to the astonishment of scientists. In 1999, another species (Latimeria chalumnae) was discovered in Asian waters.

    Due to the rarity of specimens in museums, researchers from USP and the Smithsonian Institution’s National Museum of Natural History had to persevere to find an institution willing to lend animals for dissection.

    The Field Museum in Chicago and the Virginia Institute of Marine Science, both in the United States, finally agreed to lend one specimen each. According to Datovo, G. David Johnson, co-author of the article, deserves credit for obtaining the loan.

    Johnson, born in 1945, was “probably the greatest fish anatomist of his time,” according to Datovo. He died in November 2024 after a domestic accident while the study was under review.

    Contribution

    “Contrary to what it may seem, dissecting a specimen does not mean destroying it as long as it’s done properly,” says Datovo.

    The researcher, who has been conducting this type of study for over 20 years, spent six months separating all the muscles and skull bones of the coelacanth. These structures are now preserved and can be studied individually by other scientists, eliminating the need to dissect a new animal.

    Seeing each muscle and nerve firsthand allowed the authors to identify what was actually in the coelacanth’s head with certainty, point out previously undescribed structures, and correct errors that had been repeated in the scientific literature for over 70 years.

    “There were many contradictions in the literature. When we finally got to examine the specimens, we detected more errors than we’d imagined. For example, 11 structures described as muscles were actually ligaments or other types of connective tissue. This has a drastic consequence for the functioning of the mouth and breathing, because muscles perform movement, while ligaments only transmit it,” he explains.

    Due to the position of coelacanths in the vertebrate tree of life, the discovery impacts our understanding of cranial evolution in all other large vertebrate groups.

    With this information, the researcher used three-dimensional microtomography images of the skulls of other groups of fish, both extinct and living. These images are made available by other researchers who study fish anatomy when they perform 3D scans.

    From images of the skull bones of other fish from completely extinct lineages, Datovo and Johnson were able to infer where the muscles found in coelacanths would fit, elucidating the evolution of these muscles in the first jawed vertebrates. In future work, Datovo intends to analyze similarities with the muscles of tetrapods, such as amphibians and reptiles.

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  • Immunotherapy shows promise in changing leukemia’s cellular environment

    Immunotherapy shows promise in changing leukemia’s cellular environment

    Scientists studying a hard-to-treat form of blood cancer called acute myeloid leukemia (AML) have found that a type of treatment – immunotherapy – may help change the environment where cancer cells live, possibly helping the immune system respond more effectively.

    In a new study published in July in Science Advances, a team of researchers – including scientists with Virginia Tech’s Fralin Biomedical Research Institute Cancer Research Center in Washington, D.C. – examined bone marrow samples from adult patients with relapsed or refractory AML, a serious and often aggressive form of the disease that is difficult to treat and associated with poor outcomes.

    In these patients, the cancer had either returned or failed to respond to earlier treatment. 

    The subjects in the study were treated with two drugs: pembrolizumab, which helps the immune system attack cancer cells, and decitabine, which affects how certain genes are switched on or off. 

    While the treatment didn’t work for everyone, some patients showed signs that immune cells were mobilizing in the bone marrow – and researchers wanted to understand why.

    To explore this, a large team of scientists from multiple institutions used high-powered tools to examine the patients’ bone marrow, including an analytical technique called single-cell spatial transcriptomics to understand where and how genes were active in the bone marrow. 

    This method, combined with advanced computer analysis, can examine individual cells in a biopsy sample and identify which RNA molecules are present in each cell, while keeping track of exactly where each cell is located. 

    This gave researchers a much clearer picture of how the immune system was responding to treatment and how it was interacting with leukemia cells. With this approach, the team found that certain immune cells moved closer to leukemia cells after treatment for some patients. 

    This change in cellular neighborhoods could reflect an immune system trying to fight back. The researchers also noticed changes in how cells were communicating – possibly a clue about how the treatment affects cancer’s ability to hide from the immune system.

    “Our findings show how immunotherapy may shift the types of cells found in the neighborhood around leukemia cells,” said Gege Gui, the study’s first author and a research scientist with the Fralin Biomedical Research Institute Cancer Research Center in Washington, D.C., who was also a doctoral student with the Johns Hopkins University when the research was conducted. 

    “That gives us clues about how the immune system and cancer interact – and how we might help patients by advancing our understanding of underlying biological mechanisms.”

    Christopher Hourigan, director of the Fralin Biomedical Research Institute Cancer Research Center in Washington, D.C. and one of the senior authors of this work, said this kind of detailed, cell-by-cell analysis can reveal patterns that aren’t visible through traditional methods.

    I am impressed by the potential of the careful work Dr. Gui has done integrating powerful computational approaches with these novel genomic tools.Too often cancer therapy doesn’t work as well as we would like for patients with AML, but research like this is getting us to a stage where we can start understanding why that may be so that we can hopefully design better treatments in the future.”


    Christopher Hourigan, Director,  Fralin Biomedical Research Institute Cancer Research Center

    Hourigan, a professor at the Fralin Biomedical Research Institute and the Virginia Tech Carilion School of Medicine, is an oncologist and physician-scientist who focuses on research in translational medicine and precision oncology. Laura Dillon, a research associate professor at the Fralin Biomedical Research Institute Cancer Research Center in Washington, D.C. also contributed to this work.

    The study was a collaborative effort across several major research centers. 

    Corresponding authors, Kasper Hansen, from Johns Hopkins University, contributed expertise in statistical genomics and computational analysis of high-throughput genomic data; Chen Zhao, from the National Cancer Institute of the National Institutes of Health, provided insights into tumor immunology and advanced tissue imaging techniques, including spatial transcriptomics.

    Source:

    Journal reference:

    Gui, G., et al. (2025). Single-cell spatial transcriptomics reveals immunotherapy-driven bone marrow niche remodeling in AML. Science Advances. doi.org/10.1126/sciadv.adw4871.

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  • Wasps May Unlock Key to Slowing Aging Process

    Wasps May Unlock Key to Slowing Aging Process

    Scientists have discovered that jewel wasps can slow down their biological rate of ageing.

    A study of jewel wasps, known for their distinctive metallic colours, has shown that they can undergo a kind of natural ‘time-out’ as larvae before emerging into adulthood with this surprising advantage.

    The groundbreaking study by scientists at the University of Leicester, has now been published in the journal, PNAS . It reveals that this pause in development within the wasp dramatically extends lifespan and decelerates the ticking of the so-called “epigenetic clock” that marks molecular ageing.

    Ageing isn’t just about counting birthdays, it’s also a biological process that leaves molecular fingerprints on our DNA. One of the most accurate markers of this process is the epigenetic clock, which tracks chemical changes in DNA, known as methylation, that accumulate with age. But what happens if we alter the course of development itself?

    To find out, a team at the University of Leicester including first author PhD student Erin Foley, Dr Christian Thomas, Professor Charalambos Kyriacou, and Professor Eamonn Mallon, from the department of Genetics, Genomics and Cancer Sciences , turned to Nasonia Vitripennis, also known as the jewel wasp.

    This tiny insect is becoming a powerful model for ageing research because, unlike many other invertebrates, it has a functioning DNA methylation system, just like humans, and a short lifespan that makes it ideal to study.

    The researchers exposed jewel wasp mothers to cold and darkness, triggering a hibernation-like state in their babies called diapause. This natural “pause button” extended the offsprings’ adult lifespan by over a third. Even more remarkably, the wasps that had gone through diapause aged 29% more slowly at the molecular level than their counterparts. Their epigenetic clocks ticked more leisurely, offering the first direct evidence that the pace of biological ageing can be developmentally tuned in an invertebrate.

    “It’s like the wasps who took a break early in life came back with extra time in the bank,” said Evolutionary Biology Professor Eamonn Mallon, senior author on the study.

    “It shows that ageing isn’t set in stone, it can be slowed by the environment, even before adulthood begins.”

    While some animals can slow ageing in dormant states, this study is the first to show that the benefits can persist after development resumes. What’s more, the molecular slowdown wasn’t just a random effect, it was linked to changes in key biological pathways that are conserved across species, including those involved in insulin and nutrient sensing. These same pathways are being targeted by anti-ageing interventions in humans.

    What makes this study novel and surprising is that it demonstrates a long-lasting, environmentally triggered slowdown of ageing in a system that’s both simple and relevant to human biology. It offers compelling evidence that early life events can leave lasting marks not just on health, but on the pace of biological ageing itself.

    Professor Mallon added: “Understanding how and why ageing happens is a major scientific challenge. This study opens up new avenues for research, not just into the biology of wasps, but into the broader question of whether we might one day design interventions to slow ageing at its molecular roots. With its genetic tools, measurable ageing markers, and clear link between development and lifespan, Nasonia vitripennis is now a rising star in ageing research.

    “In short, this tiny wasp may hold big answers to how we can press pause on ageing.”

    Funding for the study was provided by The Leverhulme Trust and The Biotechnology and Biological Sciences Research Council (BBSRC).

    /Public Release. This material from the originating organization/author(s) might be of the point-in-time nature, and edited for clarity, style and length. Mirage.News does not take institutional positions or sides, and all views, positions, and conclusions expressed herein are solely those of the author(s).View in full here.

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