Category: 7. Science

Scientists at the University of California, Davis, used artificial intelligence to help plants recognize a wider range of bacterial threats — which may lead to new ways to protect crops like tomatoes and potatoes from devastating diseases. The study was published in Nature Plants.

Plants, like animals, have immune systems. Part of their defense toolkit includes immune receptors, which give them the ability to detect bacteria and defend against it. One of those receptors, called FLS2, helps plants recognize flagellin — a protein in the tiny tails bacteria use to swim. But bacteria are sneaky and constantly evolving to avoid detection.

“Bacteria are in an arms race with their plant hosts, and they can change the underlying amino acids in flagellin to evade detection,” said lead author Gitta Coaker , professor in the Department of Plant Pathology.

To help plants keep up, Coaker’s team turned to using natural variation coupled with artificial intelligence — specifically AlphaFold, a tool developed to predict the 3D shape of proteins and reengineered FLS2, essentially upgrading its immune system to catch more intruders.

The team focused on receptors already known to recognize more bacteria, even if they weren’t found in useful crop species. By comparing them with more narrowly focused receptors, the researchers were able to identify which amino acids to change.

“We were able to resurrect a defeated receptor, one where the pathogen has won, and enable the plant to have a chance to resist infection in a much more targeted and precise way,” Coaker said.

Why it matters

Coaker said this opens the door to developing broad-spectrum disease resistance in crops using predictive design.

One of the researchers’ targets is a major crop threat: Ralstonia solanacearum, the cause of bacterial wilt. Some strains of the soil-borne pathogen can infect more than 200 plant species, including staple crops like tomato and potato.

Looking ahead, the team is developing machine learning tools to predict which immune receptors are worth editing in the future. They’re also trying to narrow down the number of amino acids that need to be changed.

This approach could be used to boost the perception capability of other immune receptors using a similar strategy.

Other authors of the study include Tianrun Li, Esteban Jarquin Bolaños, Danielle M. Stevens and Hanxu Sha of UC Davis and Daniil M. Prigozhin of Lawrence Berkeley National Laboratory.

The research was supported by the National Institutes of Health and the United States Department of Agriculture’s National Institute for Food and Agriculture.

1. Deflecting asteroids without breaking them
2. As a last resort… a nuclear charge

The impact of an asteroid from outer space on Earth is a real risk. If it were to happen, depending on its size, the damage it would cause to the planet could be catastrophic, causing mass extinctions and altering living conditions, as has already happened in the distant past and as evidenced by the traces left on our Blue Planet.

Fortunately, the collision of a celestial body with Earth is the ‘only natural disaster that we can prevent today’. This is according to the scientist responsible for the European Space Agency’s (ESA) main planetary defence programmes, German Michael Kueppers, who works at the European Space Astronomy Centre (ESAC) in Villanueva de la Cañada, near Madrid.

NATO and many armed forces of allied nations, including Spain, have established centres for monitoring outer space. Since 20 November 2019, the Atlantic Alliance has considered outer space to be an operational domain, similar to the land, sea, air and cyber domains. 

However, the global security of our space environment, now known as planetary defence, is not subject to military control, let alone under the umbrella of NATO. It remains within the sphere of action of space agencies and ad hoc coordination organisations, such as the International Asteroid Warning Network (IAWN) and the Space Mission Planning Advisory Group (SMPAG), both within the UN. 

This is because military concerns are focused on detecting and tracking the launch, flight and re-entry of intercontinental and hypersonic ballistic missiles in the different layers of the Earth’s atmosphere. They are also concerned with what is happening in low orbits, especially above 450-500 kilometres, where most spy satellites are located. And in medium orbits, above 5,000 kilometres, which are occupied by navigation devices. Up to the geostationary orbit, which reaches 36,000 kilometres, the height at which many communications satellites are placed. 

Deflecting asteroids without breaking them

But beyond 36,000 kilometres, the real protagonists are the space agencies, primarily those of the United States (NASA), the European intergovernmental agency (ESA), China (China), Japan (JAXA) and even the European Union Agency for the Space Programme (EUSPA), which also has an initiative called Space Situational Awareness (SSA), one of whose components is the detection of asteroids and comets.

In January 2016, NASA established a Planetary Defence Coordination Office to track, find and monitor asteroids and celestial bodies that could pose a danger to Earth. Its headquarters are located at the Agency’s headquarters in Washington. The ESA had already created a similar organisation in May 2013, located at its Earth Observation Centre (ESRIN) in Frascati, about 20 kilometres south of Rome.

Working in Frascati is Juan Luis Cano, the information coordinator for ESA’s Planetary Defence Office, who took part in a recent international simulation exercise organised by the SMPAG involving researchers and technicians from some 20 space agencies. The exercise culminated in the 9th Planetary Defence Conference organised by the International Academy of Astronautics and held from 5 to 9 May in Cape Town, South Africa. 

In the challenging real-time training exercise, ‘we implemented and validated action protocols with the aim of choosing the best possible alternatives for deflecting a hypothetical asteroid on a collision course with Earth,’ summarises Cano. Scientists and engineers agreed on three options for dealing with major threats from outer space. The first is to collide what is known in space jargon as a ‘kinetic impactor,’ for example, a space probe or a spacecraft associated with it.

This is what NASA did in September 2022 with the DART mission against the asteroid Dimorphos, a body about 163 metres in diameter and larger than the Colosseum in Rome. For Michael Kueppers, the impact marks ‘a turning point in planetary defence’ as it has effectively demonstrated a technology that, ‘for the first time, has managed to change the orbit of a small asteroid around a larger one, Didymos, almost five times its size’.

Now, since early October, ESA’s Hera mission has been travelling towards Dimorphos, which it will reach in late 2026. A probe weighing more than 800 kilograms and a European complement to the American DART, one of Hera’s main objectives is to quantify how Dimorphos’ mass has changed after the explosion. ‘We know that the impact was so strong,’ emphasises Juan Luis Cano, ‘that we suspect it was very close to the disruption limit, i.e. on the verge of fragmenting.’ This is a ‘very important issue for us, because what we want to avoid is the body breaking up, which would mean that instead of having one problem, we would have several.’

As a last resort… a nuclear charge

The second agreed method for deflecting an asteroid is to subject it to what has been called ‘ion beam herding.’ Essentially, this involves reaching the vicinity of the object whose trajectory you want to change, synchronising with its flight and projecting an ion beam emitted by an electric propulsion engine. ‘The energy of the ion beam striking the asteroid would be what would change its trajectory,’ explains Juan Luis Cano.

Proposed several years ago by a team from the Polytechnic University of Madrid, the method offers the advantage of ‘exquisite control over the asteroid,’ says the Spanish coordinator. The energy of the beam projected is ‘continuous over time’ but, with current technology, ‘it is very small’. In our simulations, we have found that the solution ‘is promising in cases where more than 15 years are available to move the asteroid from its original trajectory’. And that much time is not always available, quite the contrary.

But what is the population of near-Earth objects (NEOs), rocky debris swarming through the cosmos that is the waste from the formation of our solar system some 4.6 billion years ago? Juan Luis Cano confirms that any object smaller than 10 metres, of which there are around 45 million, ‘are of very little concern to us, because they will be almost completely destroyed upon entering the atmosphere’. However, according to data collected by NASA on 30 June this year, 38,612 larger NEOs have already been discovered.

Of these, the most dangerous due to their destructive effects are those larger than one kilometre—more than three times the height of the Eiffel Tower—of which 872 have already been identified—four of them 10 kilometres long—and it is estimated that around fifty remain to be found. Of those measuring 140 metres, slightly larger than the Egyptian pyramid of Cheops, 11,324 have been found, and researchers believe that around 14,000 remain to be located. It is estimated that there are around 120,000 measuring 50 metres, of which less than 10 per cent have been identified.

‘We know that with bodies less than 500 metres in diameter, a ‘kinetic impactor’ is likely to be more than enough’ to achieve deflection, emphasises Juan Luis Cano. But for larger objects, ‘slightly more drastic’ solutions would have to be considered. ‘We would probably have to use much more powerful devices, such as nuclear charges.’

The use of nuclear technology is highly controversial. The Spanish engineer points out that, at present, ‘it is a solution that NASA has not ruled out and that the United Nations Security Council could approve… if necessary.’ However, he insists that ‘NEOs of around one kilometre in size have almost all been located and are far fewer than those of smaller dimensions’, so based on probability calculations, ‘most of the objects that we may be forced to deflect can be dealt with using a ‘kinetic impactor’ and we will not need to resort to more radical technologies’.

It’s easy to think the periodic table never changes. It’s found on the wall of every lab and science classroom in the world. It’s a guide to the building blocks of matter, and they aren’t known to change over time. But nothing could be further from the truth. The periodic table is the ultimate living document of chemistry – and its updates happen more often than even most chemists realise.

‘People always think that the current version of the periodic table is the same one they had in their textbooks,’ explains Johanna Irrgeher, associate professor at the University of Leoben, Austria. ‘But its numbers are not constants – especially the atomic weights. It’s dynamic, the numbers aren’t stable. And people have no idea how these changes relate to their lives, and the future, even if they know the periodic table is substantial.’

The current periodic table just represents the best of our current knowledge. And, as the chair of the International Union of Pure and Applied Chemistry (Iupac) commission on isotopic abundances and atomic weights, Irrgeher is a key part of making sure that understanding is reflected in chemistry’s talisman.

Matter of fact

The periodic table has already evolved radically since Dimitri Mendeleev’s design in 1869. This isn’t just down to discovering new elements, changing names or refining atomic measurements; the entire layout of the table has moved as our knowledge has expanded. For instance, Mendeleev wasn’t convinced that the noble gases existed, and was initially doubtful when they began to appear thanks to the discovery of helium and the work of William Ramsay. Similarly, in the 1930s the actinoids occupied the seventh row of the periodic table, instead of their current place in the f-block with the lanthanoids; it was only through the work of scientists led by Glenn Seaborg at the University of California, Berkeley, that it was realised they belonged as a separate series. The seventh row of the periodic table wouldn’t be completed until the 2015.

Almost every SI unit has been affected at one point or another through better isotope measurements

Juris Meija, National Research Council of Canada

These arguments about the table’s design are far from over, too. ‘There are so many changes happening,’ says Juris Meija, a senior research officer at the National Research Council of Canada and the past chair of the Iupac commission. ‘Even the actual shape of the table changes. About 10 years ago, there was a big kerfuffle about where yttrium and scandium belonged, where does group 3 start [and which pair of actinoids and lanthanoids belong in the group]? And the outcome of an entire Iupac project was that no one could really agree.’ The debate around group 3 continues even now; it’s why, diplomatically, the official Iupac table keeps the lanthanoids and actinoids separate from the main table, and leaves a hole in the periodic table waiting for either lanthanum and actinium, or lutetium and lawrencium, to claim their place. An even greater change is likely to come if element 121 is discovered, given it would theoretically start a g-block of electron subshells, meaning its position on the table – assuming it follows the trends of periodicity at all – could be somewhere entirely new.

But while these changes are on a grand scale, the commission’s focus is on a smaller, but no less important task: ensuring the atomic weights of the elements reflect the latest knowledge around isotopes.

As elements have different isotopes, with a varying number of neutrons, that occur in different amounts naturally, it means you must account for these variations when deciding an element’s official (Iupac calls it ‘standard’) atomic weight. For example, while carbon-12 is the most abundant isotope, small amounts of heavier isotopes, such as carbon-13, mean its real-world atomic weight is around 12.011. 

‘A high school lab is happy with hydrogen atom equalling an atomic weight of one. But when [Nobel prize winning chemist] Francis Aston started doing the very first isotopic ratio measurements, in the 1920s, he found that it’s 1.008. And that 0.008 is significant as this small excess in mass suggested to Aston that hydrogen atom stores an immense amounts of energy. Indeed, each next decimal digit is where new science begins. So, we need to figure these numbers to pave a way for future discoveries.’

Ratio concerns

As isotopic ratios are measured and reassessed, the committee updates the periodic table accordingly. This requires a careful balancing act between the practical and pedantic, Irrgeher explains. ‘We always need to make sure that people can use the numbers that are being presented, and they’re presented in a suitable form. Our core mission is to meet global needs.’

This has resulted in the latest version of the periodic table, from 2022, where the majority of elements have error bars for their atomic weights; some are measured down to a single decimal place, while others are accurate up to four places. It’s a level of precision that probably won’t be useful for most chemists. But the Commission must think about a far greater picture.

‘It’s a question of scale and consequence,’ explains Steve Liddle, an expert in actinide chemistry at the University of Manchester, UK. ‘Weighing out beyond a few decimal places may not make much difference on a gram scale, but if you’re operating on a megaton scale, any difference will be magnified to significant quantities. Alternatively, if you’re working on a very small scale, any difference could constitute an error that is a large proportion of the quantity being considered.’

Isotopic ratios have had huge implications for just about every research discipline for more than 100 years. In the early 20th century, the red light emitted by cadmium lamp was among the most reliable standards for length measurement. Unfortunately, isotopes hadn’t been discovered, and it was later found that each cadmium isotope has a slightly different wavelength, resulting in the method having to be abandoned in favour of single isotope light sources. It’s why even seemingly fixed SI units such as the metre aren’t necessarily as certain as we think; they all change thanks to chemistry.

In nuclear science, you need to know the isotopic composition to understand reactions and decay rates

Steve Liddle, University of Manchester, UK

Meija was involved in the redefinition of the kilogram in 2018, which was based in part on the Avogadro project, which helped to define the kilogram by characterising one of the most perfect objects ever made – a grapefruit-sized sphere of silicon crystal. Suddenly, the isotopic composition of silicon was critical. ‘We needed to come up with the molar mass of silicon in this specific sample to nail down the Avogadro constant,’ says Meija. Since the Planck constant and Avogadro constant are closely related, and a more precise Planck constant was needed to redefine the kilogram, suddenly measuring silicon isotopes not only affected the definition of the mole, but also the kilogram. Similarly, a more precise Boltzmann constant was needed for the 2018 redefinition of the kelvin. This was achieved by measuring the speed of sound in argon. But what argon? You need the exact isotopic composition and therefore isotopic measurements.’

Prior to this, in 2005, the definition of the kelvin acquired a footnote about isotopic compositions, too. It was then based on the triple point of water. ‘Well, what water?’ Meija laughs. ‘If you take heavy water [with extra neutrons], it’s not going to melt at the same temperature as the normal water! Almost every SI unit has been affected at one point or another through better isotope measurements. It’s a little, pesky thing, but if you want to get high precision, you have to worry about the isotopic structure of matter.’

These aren’t small concerns. ‘In radiochemistry and nuclear science, you need to know the isotopic composition accurately to understand nuclear reactions and decay rates,’ Liddle says. ‘In turn, that impacts assessing radiation hazards, dating materials, and having insight into fundamental natural processes such as element formation or the movement of radioactive materials in the environment.’

Mass hysteria

Given the importance of the Commission’s decisions, it’s unsurprising that their work is meticulous. It meets regularly, looking at the latest measurements on elements. ‘The biggest change we had was the transition from chemical measurements to physical measurements,’ says Irrgeher. ‘That was the advent of mass spectroscopy in the 1930s and 1940s. We’re still using the same sources now. But we’ve had changes to electronics, more sensitive detectors, higher dynamic ranges. This allows us to be more precise and remove uncertainty. And these are the two most significant factors that could lead to a potential change of the atomic weight.’

Just because a measurement is old, doesn’t mean it’s wrong

Johanna Irrgeher, University of Leoben, Austria

The Commission doesn’t just take the latest measurements; like all science, it looks at the wider context of research before making an adjustment. ‘Most isotopic measurements aren’t done to revise the periodic table,’ Meija says. ‘They’re done for environmental science, or geology, which isn’t always relevant for us. We have a lot of papers to sift through to actually get the measurements of interest to us.’

This means that less investigated elements, such as tellurium, might not be as updated as regularly. ‘That’s not to say there are no recent measurements of tellurium,’ Meija adds. ‘It’s just that the number on the periodic table hasn’t benefited from them.’ Right now, tellurium remains the only element on the periodic table that has an atomic weight still based on old-school wet chemistry measurements.

‘Just because a measurement is old, doesn’t mean it’s wrong or bad,’ Irrgeher adds. ‘We still have some elements where we rely on measurements that date back a few decades. They’re fabulous. You wonder how people were able to do such precise and accurate measurements at the time. Whenever new data come up, we check how well it lines up with historical data. It’s surprising how often it lines up with work from the 1950s or earlier. One of the latest changes was to the weight of zirconium, and we were still using data from the 1960s.’

Once some new data have been identified, the commission then has to decide how much emphasis to put on the new data, weighing its precision, methodology and results against the body of evidence from previous work. ‘We have 13 rules,’ Meija says. ‘Almost like 13 commandments. They’re things like whatever rule you apply to one element, should apply to all elements – you can’t just make one rule for lithium and one for boron because it’s your favourite. The most common-sense rule is that whatever we do, it has to be data that has come from peer-reviewed publications.’

This does not stop the commission’s members being contacted regularly with some interesting interpretations from enthusiasts around the world. ‘We often get things such as uranium being on the wrong spot in the table as part of a government conspiracy,’ Meija sighs. ‘Or new periodic tables that have holes in the middle for elements that haven’t been discovered.’

Enigmatic variations

One of the commission’s 13 rules is that elements are only updated when there is compelling evidence for change. But even if the data suggest an adjustment is required, this isn’t always straightforward. Often, rival groups will come up with conflicting values for a new weight, and the commission has to reach a consensus on what the new value will be.

‘We have to take a decision on how many significant digits, and how much uncertainty there is,’ Irrgeher explains. The commission also doesn’t try to reflect all possible isotopes of an element, meaning that rarer synthesised species are discounted, as they would artificially expand a range. ‘We take into account how likely it is that, with 99% of the materials you have in your lab, the standard atomic weight is suitable to work with.’

This practical aspect means some elements can end up with footnotes or even standard ranges; for example, lead has two different official atomic weights – 206.14 and 207.94. This is because its three heaviest stable isotopes are all end-products of radioactive decay, and the isotopic composition can be radically different from sample to sample, depending on the source. These natural variations in samples are being increasingly reported, meaning the committee has to look at the data, and consider whether it’s relevant. ‘It’s a hell of a lot of work,’ Irrgeher adds. ‘But we had an expert on the commission; one member compiled more than 5000 publications on lead isotopes to work out the variations.’

Once the complete measurement range has been decided, the commission’s work isn’t over. It still has to take all of the nuances and condense it into a number that works. ‘You can’t just take the mid-value, because you’ll get an atomic weight that doesn’t exist in any material in the world,’ Irrgeher says. ‘For example, lithium and boron have two peaks [of isotopes], but hardly any material in the middle of the range. There are now elements [such as technetium] that don’t have a standard atomic weight listed, simply because we work with individual isotopes of technetium.’

The type of work being done with an element also impacts the level of detail the commission provides. Heavy metals such as molybdenum, zirconium and lutetium all have very small isotopic variations in nature, so can have very precise atomic weights for them. ‘Recent publications have tended to focus on heavy metals used for isotope work,’ Irrgeher adds. ‘These have only been measured successfully in the past 15 years, simply because instrumentation became better, and we can be more precise in what we measure.’

Given the amount of research now being conducted around the world, there is no shortage of papers for the commission to analyse and consider, meaning it’s unlikely the periodic table will ever reach a state where it’s finished. ‘There’s so much being published at the moment,’ Irrgeher says, ‘there will certainly be changes on a constant basis. Until forever, I would say.’

And for those who still don’t think the periodic table is detailed enough? ‘In the end,’ Irrgeher smiles, ‘if you need it super-precise and super-accurate, then you can always measure the atomic weight in your material yourself, can’t you?’

Kit Chapman is a science writer based in Edinburgh, UK

What is the purpose of AeroVironment and JPL’s Skyfall concept? Skyfall is a Mars exploration concept designed to deploy six autonomous helicopters to scout potential landing sites for future human missions and gather scientific data from the Martian surface and subsurface.

How does Skyfall differ from the Ingenuity Mars Helicopter? Unlike Ingenuity, which was a single rotorcraft used for flight demonstrations, Skyfall would involve six helicopters operating independently to collect more data across a wider area using high-resolution imaging and radar.

What is the Skyfall Maneuver? The Skyfall Maneuver is a proposed method for deploying the helicopters from their entry capsule during descent through Mars’ atmosphere, allowing them to land autonomously without a traditional landing platform.

ARLINGTON, Va. – AeroVironment Inc., based in Arlington, Va., in collaboration with the National Aeronautics and Space Administration’s (NASA) Jet Propulsion Laboratory (JPL), has introduced Skyfall, a next-generation Mars exploration concept designed to advance autonomous aerial scouting in support of future human missions to the Red Planet.

The concept envisions deploying six autonomous helicopters to explore potential landing sites for the first crewed mission to Mars. The rotorcraft would transmit high-resolution surface images and sub-surface radar data back to Earth, helping scientists identify areas rich in water, ice, and other resources critical to supporting human exploration.

No platform necessary 

Skyfall incorporates a new technique called the “Skyfall Maneuver,” which would release the helicopters from their descent capsule mid-entry, allowing them to fly autonomously to the surface. This would eliminate the need for a dedicated landing platform, one of the most expensive and complex elements of Mars missions.

NASA selects three new instruments to advance lunar science

“Skyfall offers a revolutionary new approach to Mars exploration that is faster and more affordable than anything that’s come before it,” said William Pomerantz, head of space ventures at AeroVironment. “With six helicopters, Skyfall multiplies the range, data collection, and research we can conduct.”

The concept builds on the Ingenuity Mars Helicopter, also co-developed by AeroVironment and JPL. Ingenuity made 72 flights over three years – far surpassing its initial targets – and demonstrated the feasibility of powered flight on another planet.

Tech transfer

JPL plans to transfer some Ingenuity technologies to AeroVironment for Skyfall, including avionics, flight software, and modeling systems. Trace Stevenson, President of Autonomous Systems at AeroVironment, said the new mission could support both future crewed exploration and planetary science research.

Skyfall is part of the broader AV_Space portfolio, which includes satellite communications, laser data links, and phased array ground systems for command and control. Aiming for a potential 2028 launch, AeroVironment has already begun internal investment and coordination with NASA JPL to meet the upcoming planetary alignment window.