Category: 7. Science

  • No suffering, no death, no limits: the nanobots pipe dream

    No suffering, no death, no limits: the nanobots pipe dream

    In 2000, Bill Joy, the co-founder and chief scientist of the computer company Sun Microsystems, sounded an alarm about technology. In an article in Wired titled ‘Why the Future Doesn’t Need Us’, Joy wrote that we should ‘limit development of the technologies that are too dangerous, by limiting our pursuit of certain kinds of knowledge.’ He feared a future in which our inventions casually wipe us from the face of the planet.

    The concerns expressed in Joy’s article, which prompted accusations of Luddism from tech advocates, sound remarkably similar to those now being voiced by some leaders in Silicon Valley that artificial intelligence might soon surpass us in intelligence and decide we humans are expendable. However, while ‘sentient robots’ were a part of what had spooked Joy, his main worry was about another technology that he figured might make that prospect imminently possible. He was troubled by nanotechnology: the engineering of matter at the scale of nanometres, comparable to the size of molecules.

    In fact, it would be more accurate to say Joy was troubled by the version of nanotechnology that he had read about in the book Engines of Creation (1986) by the engineer K Eric Drexler, a graduate of the Massachusetts Institute of Technology. At the close of the 20th century, it was nanotechnology, not AI (which didn’t seem to be getting very far), that loomed large as the enabler of utopias and dystopias. Drexler’s book described a vision of nanotech that could work wonders, promising, in Joy’s words, ‘incredibly low-cost solar power, cures for cancer and the common cold’ as well as ‘[low-cost] spaceflight … and restoration of extinct species.’

    But Joy had learnt from the inventor Ray Kurzweil (now a scientific adviser to Google) that Drexler’s nanotech promised something yet more remarkable: the singularity, a point at which our accelerating technological prowess reaches escape velocity and literal marvels become possible – in particular, immortality through the merging of human and machine, so that we could upload our minds to computers and live forever in a digital nirvana.

    ‘[N]anotechnology-based manufacturing devices in the 2020s will be capable of creating almost any physical product from inexpensive raw materials and information,’ Kurzweil wrote in his book The Singularity Is Near (2005). The technology ‘will provide tools to effectively combat poverty, clean up our environment, overcome disease, extend human longevity, and many other worthwhile pursuits.’

    But, Joy learned, there was a downside to all this. Drexler’s nanotechnology could get out of hand, unleashing swarms of invisibly tiny nano-robots that blindly start pulling everything apart, atom by atom, until they have reduced the world to what Drexler called ‘grey goo’. In the late 1990s, the grey-goo problem was the golem that, like ‘superintelligent AI’ today, might bring about our hubristic downfall.

    You might have noticed that none of this has happened. No cures for cancer, no mind-uploading immortality, but no grey goo either. This is because Drexler’s vision of nanotechnology was a chimera. It was like the philosophers’ stone of the alchemists: magic dressed in the science of its time, by means of which almost anything becomes possible. I call these oneiric technologies: they do not and quite probably cannot exist, but they fulfil a deep-rooted dream, or a nightmare, or both.

    These techno-fantasies are central to the utopias regularly forecast by tech billionaires

    These are not simply technologies of the future that we don’t yet have the means to realise, like the super-advanced technologies that Arthur C Clarke said we would be unable to distinguish from magic. Rather, oneiric technology takes a wish (or a terror) and clothes it in what looks like scientific raiment so that the uninitiated onlooker, and perhaps the dreamer, can no longer tell it apart from what is genuinely on the verge of the possible. Perpetual motion is one of the oldest oneiric technologies, although only since the 19th century have we known why it won’t work (this knowledge doesn’t discourage modern attempts, for example by allegedly exploiting the ‘quantum vacuum’); anti-gravity shielding is probably another.

    The oneiric technologies currently in vogue in Silicon Valley include the notion of terraforming other planets, transforming their geosphere and atmosphere to render them inhabitable; cryonic freezing of your head after death so that your consciousness can one day be rebooted; and the related idea of mind-uploading to computer circuits. These techno-fantasies are central to the utopias regularly forecast by tech billionaires. They interconnect in a nexus to which Drexlerian nanotechnology is central.

    It is worth looking into that particular dream, not just because of the parallels with the fantastical claims and fears about AI today, but because even now Drexlerian nanobots have not gone away. Kurzweil still cites them as the reason why his singularity is even ‘nearer’ – in 2024, he put it at 2045, at which point it will be possible to go (that is, to send nanobots) ‘inside the brain and capture everything in there.’ This implausible form of nanotechnology is still a part of Silicon Valley’s magical thinking, the aim of which, as the science writer Adam Becker says in his book More Everything Forever (2025), is to ‘tame the universe, to make it into a padded playground.’ No suffering, no death, no physical limits: a paradise shaped by ultra-libertarian – some say quasi-fascist – politics in which no one will tell you that anything is forbidden or impossible.

    An enthusiast of 1970s dreams of space colonisation, Drexler began thinking about nanotechnology as an undergraduate at MIT in 1977. He was inspired by a talk by the physicist Richard Feynman titled ‘There’s Plenty of Room at the Bottom’ (1959), in which Feynman imagined engineering at extremely tiny scales too small for the eye to see – and perhaps as small as could be conceived. ‘What would happen if we could arrange the atoms one by one the way we want them?’ Feynman asked. What indeed, Drexler wondered.

    In 1981, he published his core vision in the academic paper ‘Molecular Engineering: An Approach to the Development of General Capabilities for Molecular Manipulation’. But it was his book Engines of Creation five years later, a popular and non-technical account of what this capability might lead to, that made Drexler the toast of tech entrepreneurs.

    Drexler imagined making a ‘molecular assembler’, a mechanical device for grabbing atoms and pushing them together like Lego bricks. It might sound absurdly difficult to achieve that level of control and precision, but Drexler argued that we already have proof of its possibility. For isn’t this just what biology does, using machines made from protein molecules to read assembly instructions encoded in DNA and turn them into the parts of living cells? You might wonder what kind of practical manufacturing could be usefully done with a molecular-scale machine, but the key to Drexler’s vision was a progressive scaling up: small machines make bigger ones, which make bigger ones. Scaling up would also borrow another trick from nature: these molecular machines would be self-replicating, being able to assemble copies of themselves. You need only make one, and it can multiply exponentially. After publishing Engines of Creation, Drexler obtained his doctorate at MIT under the supervision of the AI guru Marvin Minsky. His thesis furnished a more technical book, Nanosystems (1992), intended as the scientific blueprint for realising the wonders promised in Engines.

    Kurzweil imagines nanobots whizzing around in our heads reading the electrical states of neurons

    With atomic-scale manipulation and assembler replication, said Drexler, we could create anything – not, as we currently do, through crude chemical processing or the laborious ‘top down’ etching and carving needed to fashion miniaturised devices such as silicon chips but from the bottom up, atom by atom. And whereas nature’s machines – proteins – are delicate and liable to fall apart if they get too warm or cold, molecular assemblers can be made of sterner stuff. Ideally, we would make them from carbon atoms, each component then in effect a little shaped piece of pure diamond. These ‘diamondoid’ nanomachines – nanoscale robotic arms, pincers, rotors, filters and so forth – wouldn’t break or corrode, and ‘will be able to build virtually anything that can be designed.’ In his book Where Is My Flying Car? (2021), Drexler’s associate and advocate, the computer scientist and writer J Storrs Hall, estimated that with nanoassemblers one could recreate the entire physical infrastructure of the United States – roads, bridges, cities – in a single week.

    Drexler’s nanotech dream, with nanoscale robots patrolling our bloodstream, killing off pathogens and stripping sclerotic deposits from the blood vessel walls, seemed just what Kurzweil needed in order to realise his aspiration of escaping death. Such nanotechnology, Kurzweil has said, ‘promises the tools to rebuild the physical world – our bodies and brains included.’ Kurzweil imagines nanobots whizzing around in our heads reading the electrical states of neurons and thereby collecting all the information held within our neural circuitry, broadcasting it to detectors to create a virtual replica of our memories and thoughts – a digital clone of our conscious state, which would experience itself as no different from the meatspace version of us. Science-fiction writers loved it. Neal Stephenson based his novel The Diamond Age (1995) on a steampunk version of Drexlerian ‘matter compilers’, namechecking Drexler and Feynman in the book.

    Scientists, however, were not so enamoured. The US chemist Julius Rebek told Scientific American in 2004: ‘This is not science – it’s show business.’ The chemistry Nobel laureate Richard Smalley engaged in an exchange of letters with Drexler published in 2003 in the American Chemical Society’s house magazine Chemical & Engineering News, in which Smalley insisted that Drexler’s idea was chemically illiterate.

    The idea of manipulating atoms one by one was not itself inherently crazy. During the 1980s, scientists at IBM’s research labs developed so-called scanning probe microscopes that move ultrafine metal needles over surfaces to create images of individual atoms and molecules sitting on them. In 1989, an IBM team in California used such an instrument to write out the company’s name in letters five nanometres tall, using the tip to nudge, individually, 35 atoms of the element xenon into position on the surface of nickel.

    Nor was Drexler wrong to think that chemical assembly at the molecular scale is possible. In the past several years, another IBM team in Switzerland has made rather complex single molecules – some of them difficult to create by conventional chemical methods – by pushing their fragments together on a surface with a scanning probe microscope until they react and join up.

    Work like this makes it rather easy to present Drexlerian nanotechnology as plausible. But there are several key problems with using such an approach to synthesise molecular assemblers that can replicate and build anything. First, chemistry is not arbitrary: you can’t put atoms together any old how. Most arrangements are simply not stable, and so they will spontaneously rearrange into more stable ones. Getting rid of the energy released when a new chemical bond is made can be a big challenge too. And perhaps most of all, treating molecular objects as though they were just scaled-down engineering devices – rotary bearings, levers, clasps and so on – ignores the realities of the molecular world, which is full of strong and uncontrollable forces between molecules and random, pervasive shaking because of heat energy, and where liquids seem as viscous as molasses. As the late Scottish chemist James Fraser Stoddart, who won the 2016 Nobel Prize for his work on artificial molecular machines, told Becker: ‘The whole idea of extrapolating from the macroscopic world, from a car or a bicycle or something like that, down to the fundamentals of how you construct artificial molecular machines just makes no sense. It’s never going to work.’

    Stoddart’s Nobel-winning work, in contrast, was firmly based on regular, known chemistry. He and others have found ingenious ways to link up molecules into structures that can carry out mechanical operations without needing to suspend physical and chemical laws. Stoddart’s breakthrough invention was a ‘molecular shuttle’ in which a ring-shaped molecule was threaded on a rod-like molecular axle capped with bulky chemical groups that prevent unthreading. The ring can jump between two docking positions on the axle, a little like an abacus bead. It’s fun to imagine such a molecular assembly being used to do abacus-style computation – but, as Stoddart knew, in practice it would be nigh-impossible to prevent the ring from making spontaneous jumps because of its thermal movements, so that the average setting of many such shuttles will be determined not by where we initially put them but by the statistical laws of thermodynamics. It’s the same story for the ‘biomolecular machines’ that were Drexler’s inspiration: they don’t work like nanoscale versions of electric motors or robot arms, but are governed by thermodynamic laws that inject random noise into their behaviour. At the molecular scale, nature is not much like mechanical engineering at all.

    Drexler tried to head off such criticism in Nanosystems, arguing that his critics were merely coming up with badly designed nanotechnology and then dismissing the whole field of ‘molecular manufacturing’ because of that bad design. If he seemed to make light of experimental difficulties, he said: ‘I can only plead that it would soon become tedious to say, at every turn, that laboratory work is difficult, and that the hard work is yet to be done.’ Sure, it’ll be hard, but we’ll manage it somehow.

    The grey-goo problem made nanotechnology a bête noir of techno-sceptics and environmentalists

    Yet Nanosystems exemplified the strategy of oneiric technologists. You start from what looks like sound science – Drexler talks about thermal motion, chemical bonds, intermolecular forces. But you move almost imperceptibly into sheer fantasy, all the while ramping up the excitement of the impressionable reader. The second half of the book presents devices such as molecular sorters – wheels that separate different types of atoms or molecules – alongside molecular conveyor belts, robotic arms, and sets of interlocking gears. There are nanoscale mechanical computers made from moving rods, effectively miniaturised versions of Charles Babbage’s Analytical Engine, his steampunk design for a general-purpose calculating machine, which he hoped to create out of brass components in the 19th century. There are, by this point, no longer any molecules in sight: we’re asked to assume these wondrous machines have all been somehow fashioned and assembled from diamondoid pieces, even though no one had ever made anything of the sort.

    Maybe it’s all just as well that this is fantasy, because then so is the grey-goo problem. In this scenario of nanotech gone rogue, nanobot molecular assemblers escape our control and replicate without check, pulling apart every scrap of matter they can lay their nano-hands on and refashioning it into more of themselves. Each nanobot being smaller than a dust grain, the world then ends up being disassembled – at frightening speed, if you believe the calculations – into featureless mush.

    The grey-goo problem made nanotechnology – which many assumed would be created in Drexler’s model – a bête noir of techno-sceptics and environmentalists in the 1990s. Among them was Prince Charles, now the British monarch, who voiced concerns in 2003 that prompted the Royal Society to produce a report on the benefits and risks of nanotech that barely mentioned Drexler, and attempted to steer the discussion back to the actual science. The grey-goo narrative was, however, far too good for science-fiction writers to resist: Michael Crichton of Jurassic Park fame got there first with his thriller Prey (2002).

    The grey-goo nightmare might sound familiar to aficionados of AI ‘existential risks’, for it is the forerunner to the philosopher Nick Bostrom’s ‘paperclip problem’. Imagine, Bostrom said in 2003, we design an all-powerful, superintelligent AI that we assign the task of making paperclips. (It would be hard to imagine a more ridiculous use of such a powerful technology, but that’s not the point – or rather, the sheer banality is part of the point.) The AI might decide that its assigned task is so important that it will stop at nothing to make more paperclips. And because we have given it such power and ingenuity, it will outwit any efforts of ours to divert it from that goal – and will promptly turn everything, including us, into paperclips. Bostrom’s point was that it would be extremely hard, perhaps impossible, to ensure that such a superintelligent AI has goals that remain aligned with ours. ‘The future that the AI would be trying to gear towards would be one in which there were a lot of paperclips but no humans,’ he told HuffPost in 2014.

    Bostrom’s scenario has been much debated, but its central problem is simply stated. Like grey goo, it involves an oneiric technology. Can’t we just switch it off? No, it is un-switch-off-able. If it’s superintelligent, won’t it figure out that we don’t want to become paperclips? No, it is superintelligent enough to be unstoppable but not enough to figure that out. And how does it turn everything into paperclips anyway? It can pull everything apart into atoms and then reassemble them at will: it is Drexlerian! Magically, it has precisely those capabilities and flaws the scenario demands, granted by unspecified (but capital-S) Science.

    More than three decades after Nanosystems was published, Drexler’s nanotechnology is not one nanometre closer. It’s not that making a replicating diamondoid molecular assembler proved rather harder than Drexler imagined. It’s that there was never any real programme for how that could be done, nor any reason to think it was possible. Not a single carbon atom has been put in place in the attempt. No scientist has deemed it worth even trying.

    Yet nanotechnology itself is now a mature science. Nanometre-scale pieces of matter of all descriptions can be assembled using chemical processes and are used in areas ranging from photovoltaic cells to biomedical imaging techniques. As well as Stoddart’s Nobel for synthetic molecular machines, the 2023 Nobel Prize in chemistry was awarded for work on nanometre-scale clusters of atoms called ‘quantum dots’ that have a panoply of applications from biomedicine to information technologies. Chemists have figured out how to ‘program’ strands of DNA so that they will fold up spontaneously, origami-style, into complex shapes and patterns smaller than a bacterium, including a minuscule map of the Americas. Scanning probe microscopes are now regularly used as tools for molecular manipulation. Ultra-strong and hollow tubes of carbon a nanometre or so wide, discovered in 1991, are the ultimate carbon fibres and have been widely used in biomedical devices, wearable electronics and tough composite materials. The one-atom-thick carbon material graphene is another star of such ‘carbon nanotechnology’, of which Smalley was a pioneer. DNA sequencing, such as that used to track new variants of the COVID-19 virus, is now often done by dragging the strands through nanometre-scale protein pores embedded in membranes, a method developed by the company Oxford Nanopore. None of this work, however, uses anything like the approach Drexler advocated. Rather, it depends on chemistry as we have always known it.

    That’s not to say Drexler’s vision was worthless. Indeed, it helped to stimulate early interest in the field, and even Smalley attested that he was initially excited by the possibilities it sketched for engineering with matter on tiny scales. Drexler attracted enough venture capital to establish in 1986 an organisation called the Foresight Institute, based in San Francisco, that today continues to offer grants and support to research on conventional nanotechnology and to award prizes (named after Feynman) to leading scientists working in the field. The institute organises conferences that attract many respectable scientists, working on topics such as protein design, which won the 2024 Nobel Prize in chemistry. At first sight, the Foresight Institute seems to have quietly set aside Drexler’s own oneiric version of nanotech.

    None of this is moored to current technologies, but requires essentially magical inventions

    But has it? The institute’s logo remains one of Drexler’s imaginary diamondoid gearwheels. It says it is now supporting work in neurotechnology, longevity biotechnology, space and ‘existential hope’. For anyone alert to the oneiric technologies of techno-utopias and dystopias, these are red flags. Neurotech – think of Elon Musk’s much-hyped Neuralink initiative for hooking up brains to machines – connects to the fantasy of mind-uploading, which Musk believes is possible. ‘We could download the things that we believe make ourselves so unique,’ he said in an interview in 2022. ‘As far as preserving our memories, our personality, I think we could do that.’ Musk says that a long-term goal for Neuralink is to ‘store your memories as a backup.’ These ideas, it’s important to recognise, are not to be confused with ambitious extrapolations of current scientific capabilities; they aren’t even coherent concepts.

    Longevity? Drexler became closely associated with the community who called themselves Extropians, a reference to the idea that we can impose ever more order and design (extropy) on the Universe rather than surrendering to the dissolution of entropy seemingly demanded by the second law of thermodynamics. Extropianism has a huge overlap with transhumanism, the idea that we humans can transcend ourselves with technological help, eventually merging with machines or totally redesigning the human form.

    Space? It’s not about making better telescopes or robotic spacecraft. Techno-utopians like Musk, Jeff Bezos and the influential software engineer and venture capitalist Marc Andreessen believe in the manifest destiny of humankind’s colonisation of space. As Becker explains in More Everything Forever, Kurzweil envisages sending out fleets of Drexlerian replicating nano-robots that transform planets and, ultimately, turn the entire accessible universe into a gigantic supercomputer with ‘exquisitely sublime forms of intelligence’. Again, none of this is moored to current technologies, but requires essentially magical inventions.

    Existential hope? Here the Foresight Institute directs you to the Abundance and Growth Fund of the philanthropic funding and advising organisation Open Philanthropy in San Francisco, which aims ‘to accelerate economic growth and boost scientific and technological progress’ and to oppose ‘(even well-intentioned) governmental regulation’ that slows progress. In other words, this concept of ‘existential hope’ is entrained with the kind of ultra-libertarian, anti-regulation project envisaged by Andreessen, Musk and other tech billionaires.

    Notably missing from such utopian goals is any mention of climate change, or threats to democracy, or arms proliferation, or corporate profiteering, or indeed any of the urgent problems facing the world here and now. Such issues don’t interest oneiric technologists, because there is nothing transcendent about them. They do not speak to immortality, to endless growth, to galactic futures, to that padded playground universe. Bill Joy summed up the matter in his 2000 article. ‘I remember feeling good about nanotechnology after reading Engines of Creation,’ he wrote. ‘If nanotechnology was our future, then I didn’t feel pressed to solve so many problems in the present. I would get to Drexler’s utopian future in due time; I might as well enjoy life more in the here and now.’

    We don’t have to buy the myths of oneiric technologies

    What messed it up for Joy was not the fact that Drexlerian nanotechnology was a pipe dream (as any number of well-informed scientists could have told him). Like all tech barons, he stayed within the club, conversing with Kurzweil (‘In the hotel bar, Ray gave me a partial preprint of his then-forthcoming book The Age of Spiritual Machines,’ says Joy, attesting to no flicker of misgiving at that title) and with the robotics futurist Hans Moravec (book title: Robot: Mere Machine to Transcendent Mind). Joy learnt about grey goo, and it made him think about Hiroshima, and his vision of an imaginary utopia turned to one of imaginary apocalypse.

    Joy was commendably trying to do the right thing: to think ethically about powerful technologies. But he lacked the resources to know what to be excited by and what to fear. Here’s what I mean. Joy had made his fortune through his role in inventing world-changing computer tech. Meanwhile, when I wrote a critical review of Nanosystems as an editor of Nature in 1993, I was a mere five years from having completed my PhD and still wet behind the ears. How come I could tell its vision was going nowhere, yet Joy couldn’t? It was most certainly not because I was some kind of prescient wunderkind. It was not because of who I was but because of who I wasn’t. My social circle wasn’t other tech leaders; I wasn’t hanging out in the bar with Kurzweil; I wasn’t in the oneiric Silicon Valley bubble. Rather, I was lucky enough to have benefitted instead from contact with scientists doing benchtop research, with the likes of Smalley and Stoddart.

    With AI, we are doing all this again. We are accepting the fantastical prophecies of the likes of Google’s former CEO Eric Schmidt, who has forecast that ‘within three to five years we’ll have … [artificial] general intelligence, which can be defined as a system that is as smart as the smartest mathematician, physicist, artist, writer, thinker, politician’ (the ‘smartest artist’ being a concept that apparently means something within Silicon Valley). With no trace of irony, Schmidt adds that ‘I call this … the San Francisco consensus, because everyone who believes this is in San Francisco.’ As part of the package, we are then asked to accept not only the fantastical dreams of this community but also their eschatology, in which a machine superintelligence wipes us out. We are entranced by such ‘existential risk’ discourse when it comes from a Musk, a Bezos, or others who have fallen into the orbit of the San Francisco consensus. And if we take their dream, we have to take their nightmare too.

    But we don’t have to. We don’t have to buy the myths of oneiric technologies. We can take a look at what happened to Drexlerian nanotechnology and diagnose the warning signs. We can choose to refuse that distraction, to heed humble experts over media-anointed geniuses. It’s perhaps not as exciting, it lacks any chiliastic frisson, and it might require us to think about boring risks and mundane regulation of research instead of science fantasy. But that’s where we live.

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  • When To See The ‘Corn Moon’ Rise

    When To See The ‘Corn Moon’ Rise

    Topline

    The full corn moon — the final full of summer in the Northern Hemisphere — will turn full on Sunday, Sept. 7, 2025, and be best viewed from North America that evening during dusk as it rises in the east. A few hours earlier, the full moon will have traveled through Earth’s shadow, causing a “blood moon” total lunar eclipse visible on the other side of the world, similar to one in North America last March.

    Key Facts

    The corn moon will turn full at 2:10 p.m. EDT on Sunday, Sept. 7, 2025. It will look full the nights either side. The best time to watch it rise in North America will be at moonrise at dusk later that day.

    September’s full moon is often called the harvest moon. However, that name is given to the full moon closest to the equinox on Sept. 22. This year, that means the next full moon, on Oct. 7, is closest, so gets that name.

    Like the harvest moon, the corn moon takes its name from the fact that crops are harvested at this time of year in North America. According to EarthSky, September’s full moon is also known as the fruit moon. Cultural and seasonal names for the full moon vary hugely across the world.

    A total lunar eclipse is a global event, but only the night side of Earth can witness it. For all stages of the eclipse on Sept. 7-8, 2025, parts of Asia, Australia and the Pacific will be on the night side while the Americas will be on the day side of Earth. No part of the eclipse will be seen from North or South America.

    Best Time To See The Full ‘corn Moon’ Rise

    For North America, the sight will be not of a “blood moon,” but of a typical full moon. A full moon always looks at its best when it first appears above the eastern horizon during dusk. Find an elevated location or an east-facing coastline with a clear view of the eastern horizon. To find the best time to see it appear from where you are, consult a moonrise calculator. Here are some sample times :

    • New York: sunset at 7:20 p.m. EDT, moonrise at 7:22 p.m. EDT on Sunday, Sept. 7.
    • Los Angeles: sunset at 7:12 p.m. PDT, moonrise at 7:19 p.m. PDT on Sunday, Sept. 7.
    • London: sunset at 7:32 p.m. BST, moonrise at 7:44 p.m. BST on Monday, Sept. 8.

    A Total Lunar Eclipse In Asia, Australia And The Pacific

    Although no part of it will be visible from North America, September’s full moon will, for some observers, also be a total lunar eclipse. Similar to the event seen in North America on March 13-14, 2025, this event will be visible from parts of Asia, Australia and the Pacific. For observers who can see the eclipse, totality — when the lunar surface turns completely red — will last 82 minutes. The entire eclipse, including the penumbral and partial phases (as the full moon moves through Earth’s fuzzy outer shadow, the penumbra, and into its dark umbra), will last five hours and 27 minutes. According to Timeanddate.com, 4.9 billion people will see the entire eclipse in September from beginning to end.

    An Inevitable Partial Solar Eclipse Two Weeks Later

    Eclipses always come in pairs and occasionally threes, with every lunar eclipse preceded and/or followed by a solar eclipse. That’s because the moon’s orbital path intersects the sun’s path through Earth’s sky (the ecliptic) twice each month. If it crosses the ecliptic as a full moon, it causes a lunar eclipse. Two weeks later, it will cross the ecliptic as a new moon, causing a solar eclipse, or vice versa. On Sept. 21, 2025 — two weeks after a total lunar eclipse — a partial solar eclipse will be seen from New Zealand, the South Pacific and Antarctica.

    Background

    The corn moon is the ninth of 12 full moons in 2025. A solar year is 365.24 days, while a lunar year is around 354.37 days, so sometimes there are 13 full moons in one calendar (solar) year — as in 2023 and next in 2028. Of the 12 full moons in 2025, three will be “supermoons” and two “blood moon” total lunar eclipses. The next full moon will be the harvest moon, the year’s first “supermoon,” on Monday, Oct. 7, 2025.

    Further Reading

    ForbesSee Two ‘Blood Moons,’ Three ‘Supermoons’ And The Biggest Full Moon Since 2019: The Moon In 2025ForbesSee The Best Photos Of Today’s Magnificent ‘Blood Moon’ Total EclipseForbesSee The Best Photos Of Today’s Magnificent ‘Blood Moon’ Total Eclipse

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  • Unifying gravity and quantum theory requires better understanding of time

    Unifying gravity and quantum theory requires better understanding of time

    Quantum mechanics is our most successful physical theory. Created to account for atomic phenomena, it has a vast range of applications extending well beyond the atomic realm, from predicting the abundances of the light elements created a few minutes after the Big Bang to understanding the properties of semiconductor materials that are the basis of advanced information technologies.

    Quantum mechanics is also successful in its exquisitely accurate predictions of fundamental parameters, such as the value of the ‘magnetic moment’ of the electron, a property linked to its electric charge and magnetic behaviour, which is predicted to an accuracy of one part in ten trillion.

    Our best current understanding of the fundamental constituents of matter, the standard model of particle physics, is a quantum theory. And the statement that every physical system is, fundamentally, a quantum system has no known counter evidence.

    In the case of gravity, however, nearly a century of effort has not resulted in a stable consensus even about the most promising grounds on which to build a theory of quantum gravity.

    Why is quantum gravity proving more challenging than other quantum theories? The reasons lie partly in the lack of definitive observational phenomenology to guide us and partly in the character of gravity, which makes quantum gravity different from all other physical theories.

    In this article I diagnose, in Albert Einstein’s words, “where the shoe pinches” in quantum gravity and describe one way forward based on physicist Richard Feynman’s alternative vision for quantum mechanics.

    Quantum foundations

    A good place to start is Werner Heisenberg’s famous 1925 breakthrough on the Danish island of Heligoland. In retrospect, the truly fresh and startling concept introduced by Heisenberg is that of transitions of the atom from one quantum state to another, transitions that do not occur in the familiar three dimensions of physical space. That breakthrough set up a conflict between the new rules of quantum prediction and the familiar, historically successful conceptual framework of physical goings-on occurring in real 3D space.

    The question of where atomic transitions occur, if not in 3D space, was not raised explicitly by Heisenberg in 1925 but was answered soon afterwards. The whereabouts of these transitions was identified and formalized mathematically by Paul Dirac and others as being the ‘Hilbert space’ of the quantum system, which comprises all conceivable quantum states of the system. In mathematics, the Hilbert space takes the form of a ‘vector space’: think of the quantum state as an arrow pointing in a particular direction in a space with many, many dimensions.

    The transitions in Hilbert space from one quantum-state vector to another affect and are affected by what occurs in physical 3D space by means of special interactions between the quantum system and instruments that exist in 3D space. Such interactions are known as measurements, and the standard quantum rules make predictions about the outcomes of measurements registered by the instruments in 3D space.

    To make these predictions, the goings-on in Hilbert space must be coordinated with the goings-on in 3D space, and this coordination is achieved using a concept of synchronized time. As time passes in Hilbert space, the vector arrow of the state of the quantum system changes. Its motion in Hilbert space is governed by a law of quantum physics, the Schrödinger equation, and is a type of rotation: the angle through which the quantum-state vector rotates in Hilbert space is proportional to the time that passes.

    Time also passes for the measuring instruments, and physicists, in physical 3D space. The situation is like a round in the long-running British comedy radio show, I’m Sorry I Haven’t a Clue, in which each celebrity contestant has to sing along with a recording of a song, then continue to sing while the recording is muted. When the recording is unmuted again, the contestant wins points if they are still singing in synch with the recording. Seriously, it’s funnier than it sounds.

    In this analogy, the song playing is like the quantum state evolving in Hilbert space, and the singer is like the measuring instrument in 3D space. The period during which the singer cannot hear the recording is like the period during which the measuring instrument is not making a measurement. The moment of unmuting is like the moment of measurement.

    In the game, the singer can get out of synch with the recording, but in quantum mechanics, the synchronization is always perfect. The time that has passed in 3D space for the measuring instrument is always in perfect synch with the time that has passed in Hilbert space, marked by the angle the state vector has rotated through.

    This perfect synchronization is so fundamental to quantum mechanics that, when working in the theory, the same symbol t is used for time in 3D physical space and for time in Hilbert space.

    By means of this concept of synchronized time, Heisenberg and his colleagues in Copenhagen established a scientifically successful détente between the two notions of the whereabouts of physical goings-on. Although the evolution of the state of the quantum system occurs in Hilbert space, scientific predictions are about instances in which the instrument measures something, which occur in physical 3D space.

    The past 100 years have proven that a quantum physicist can become extremely successful by accepting and working with the Copenhagen group’s strange ‘duality of location’. When the quantum system is gravity, however, the Copenhagen view cannot hold.

    Gravity’s exceptionalism

    Gravity is not like other physical systems. Our best theory of gravity is the general theory of relativity, which was published by Einstein in 1915. In general relativity, the physical entity that is the subject of the theory is space-time. Space-time is a physical 4D fabric with geometrical structure that bends, warps, ripples, carries energy and has its own laws of motion, which are as precise and experimentally successful as Newton’s laws of mechanics.

    In general relativity, space-time graduates from being a fixed stage on which what happens happens, to being both the stage and a dynamical actor in reality’s play in its own right. Gravity’s physical status is different from those of other systems. If particles, for example, are absent from a region of space-time, there can still be physical goings-on in that region, including warping or rippling of space-time itself. But if space-time is absent, there cannot be any particles, any electromagnetic radiation or anything else — because there’s nowhere and no-when for them to be.

    Nothing is external to space-time: every physical thing that exists in general relativity either is space-time or is in space-time. The Copenhagen requirement for a physical measuring instrument in physical space external to the quantum system is incompatible with the quantum system being space-time.

    Also, the character of physical time in general relativity stymies the synchronization that the Copenhagen détente requires. In general relativity, physical time passes individually for each particle, body or measuring instrument along its own unique, individual path, or ‘worldline’, in space-time. These individual physical worldline times cannot even be synchronized with each other and so cannot be synchronized with the time that passes in Hilbert space, as demanded by the Copenhagen rules. For quantum gravity, Heisenberg’s détente collapses, and an alternative approach is needed.

    Feynman’s alternative

    In 1985, Feynman gave a series of public lectures about quantum electrodynamics1, the theory unifying quantum mechanics and electromagnetism, for which he shared the 1965 Nobel Prize in Physics. In the lectures, he set out an alternative approach to quantum theory, in which there is no strange duality of location — quantum states evolving in Hilbert space were simply left out.

    Instead, Feynman based his explanations of quantum phenomena on events and histories in space-time, concepts that are also fundamental in general relativity. Starting in the 1980s, physicists James Hartle and Rafael Sorkin, independently, sought to build on Feynman’s approach and develop it into an alternative foundation for a quantum theory suitable for describing gravity. Here’s how the Feynmanian approach works.

    An event is something that can happen. It’s useful to have concrete examples in mind, so think of rain on a particular date in Bengaluru, India. An event has a space-time location, and it either happens or it doesn’t. Beforehand, it is uncertain whether a given event will or will not occur, but afterwards, there is no uncertainty: it either rained or it did not.

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  • Why plastic-filled ‘Neptune balls’ are washing up on beaches

    Why plastic-filled ‘Neptune balls’ are washing up on beaches

    In 2018 and 2019, Sanchez-Vidal’s team examined seagrass balls washed up on four beaches on the island of Mallorca, Spain. On the shores of Sa Marina, Son Serra de Marina, Costa dels Pins and Es Peregons Petits, they found plastic debris in half of the loose seagrass leaf samples, up to 600 fragments per kilogram (2.2lb) of leaves.

    Only 17% of Neptune balls contained plastic, but where it was found it was densely packed – nearly 1,500 pieces per kilogram. Tighter bundled balls were more effective at trapping plastic.

    “After our paper was published, a lot of people started sending me [pictures of] monster Neptune balls,” says Sanchez-Vidal. These are balls that capture larger and more visible pieces of plastic.

    “Sometimes they had sanitary towels, tampons, wet wipes – things with a lot of cellulose, so they sink,” she explains: “No, I didn’t really want to receive those pictures from everybody,” she jokes.

    Getty Images Neptune balls are natural products of Posidonia seagrass meadows, but the plastic inside some of them comes from human pollution (Credit: Getty Images)Getty Images
    Neptune balls are natural products of Posidonia seagrass meadows, but the plastic inside some of them comes from human pollution (Credit: Getty Images)

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  • Outer Space Research Threatened by Trump Cuts, Scientists Warn

    Outer Space Research Threatened by Trump Cuts, Scientists Warn

    As the sun sets on the southern edge of Chile’s Atacama Desert, the wind picks up, the temperature plummets, and the surrounding hills and mountains begin fading from view. Within minutes it’s pitch-black, with not so much as a car headlamp in sight across the vast, rocky landscape. At an altitude of more than 8,500 feet, these peaks sandwiched between the Andes and the Pacific Ocean—about a day’s drive from the capital, Santiago—rank among the driest, least hospitable places on Earth. (Props to the odd fox or herd of alpacas living among the scrub.) Yet for Chuck Claver, this is paradise. From the top of a mountain, he can see the celestial bodies dotting the night sky in unmatched brightness. The shine of faraway planets, stars and galaxies is hardly dimmed by light pollution or humidity.

    Claver is a system scientist at the Vera C. Rubin Observatory, eight stories’ worth of cutting-edge, US government-funded research perched on one of these Atacama peaks. Named for the pioneering American astronomer, the Rubin is part of a global hub of at least 10 advanced telescopes in a region renowned for its dry, clear and calm night skies. In exchange for permission to operate in the country and some tax advantages, foreign-backed observatories reserve a portion of their telescope capacity for use by Chilean astronomers.

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  • Soil DNA Test Shows Plants’ Hidden Climate Role

    Soil DNA Test Shows Plants’ Hidden Climate Role

    Plant roots are essential for both food production and climate, yet until now they have been nearly impossible to measure accurately. Researchers at Aarhus University have now developed a method that works like a “DNA test of the soil,” showing how much root biomass each species has and how much carbon they store underground.

    Few of us ever think about what happens beneath our feet when we walk through a field of wheat or clover. We see the stalks, leaves, and flowers, but in practice we have no direct access to the roots.

    Roots, however, are central. They anchor plants in the soil, supply them with water and nutrients, and contribute to carbon storage in the ground.

    But because roots are hidden, researchers have for decades struggled to measure how much biomass lies below and how it is distributed among species.

    “We have always known that roots are important, but we have lacked a precise tool to measure them. It’s a bit like studying marine ecosystems without ever being able to dive beneath the surface of the water,” says Henrik Brinch-Pedersen, professor at the Department of Agroecology, Aarhus University.

    From muddy boots to genetic fingerprints

    Until now, researchers typically measured roots by digging up large soil samples, washing the roots free, drying, and weighing them. This is a lengthy process, and the finest roots are often destroyed along the way. That is a major problem, since fine roots are the most active in absorbing nutrients and releasing carbon to the soil environment.

    The new method is instead based on droplet digital PCR (ddPCR), a DNA technology in which a soil sample is divided into tens of thousands of microscopic droplets, each of which is analyzed for the presence of DNA.

    The researchers use a genetic marker called ITS2, which works like a fingerprint for each species. In this way, they can not only see that roots are present but also identify which species they belong to and how much biomass they represent.

    “It’s a bit like giving the soil a DNA test,” says Henrik Brinch-Pedersen. “We can suddenly see the hidden distribution of species and biomass without digging up the whole field.”

    International recognition

    The method was developed by a research team consisting of Nurbanu Shynggyskyzy, Claus Krogh Madsen, Per L. Gregersen, Jim Rasmussen, Uffe Jørgensen, and Henrik Brinch-Pedersen. It has been published in the renowned journal Plant Physiology and has already received special attention in an accompanying News & Views article, where international experts highlight it as a breakthrough.

    What can it be used for?

    The new technology opens up a wide range of applications:

    • Climate research: Accurately measuring how much carbon different crops store in the soil is crucial for documenting and improving agriculture’s climate contribution.
    • Plant breeding: The method enables researchers to select varieties that send more biomass belowground without reducing aboveground yields.
    • Biodiversity: In grasslands and mixed crops, it is now possible to see how species compete or cooperate underground, something that was almost impossible before.

    “We see great potential in using this method to develop varieties that store more carbon in the soil. It could become an important tool in future agriculture,” says Henrik Brinch-Pedersen.

    Roots as a climate solution

    It is no coincidence that researchers are focusing on roots. While we usually think of wind turbines and electric cars as climate solutions, plant root systems also hold great potential in the form of biological carbon storage.

    When plants grow, they draw CO₂ from the atmosphere and send part of the carbon into their roots. There, it can remain stored in the soil for decades, or even centuries, if we can develop cropping systems that maximize this potential.

    Without precise measurement tools, however, it has been difficult to document the effect. This is where the new DNA technology could become a gamechanger.

    Limitations and next steps

    The method is not without challenges. For example, genetic hybrids such as ryegrass and Italian ryegrass can be difficult to distinguish because their DNA is so similar. And the method requires developing specific DNA probes for each species researchers wish to measure.

    “For us, the most important thing is that we have shown it can be done. That is the foundation we can build upon. Our vision is to expand the DNA library so that in the future we can measure many more species directly in soil samples,” says Henrik Brinch-Pedersen.

    Where researchers previously depended on time-consuming fieldwork, the new method allows root analysis to be carried out quickly, precisely, and on a much larger scale.

    That means researchers can now take a precise look into the underground world that has so far remained hidden.

    Reference: Shynggyskyzy N, Madsen CK, Gregersen PL, et al. Digital PCR enables direct root biomass quantification and species profiling in soil samples. Plant Physiol. 2025. doi: 10.1093/plphys/kiaf276


    This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source. Our press release publishing policy can be accessed here.

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  • UAE skywatchers set for five-hour Blood Moon during rare total lunar eclipse

    UAE skywatchers set for five-hour Blood Moon during rare total lunar eclipse

    A rare total lunar eclipse, also known as a Blood Moon, will be visible across the UAE on Sunday evening, treating skywatchers to one of the year’s most dramatic celestial sights.

    The celestial show will appear for about five and a half hours, as the Moon passes through the Earth’s shadow.

    It will play out in a sequence of phases, visible across the UAE and around the world.

    “This is one of the rare astronomical events happening in the UAE in 2025,” Khadijah Ahmed, operations manager at the Dubai Astronomy Group, told The National. “We will host an event for the eclipse and encourage everyone to witness it. You don’t need any special equipment – just go outside and look up.”

    It will be visible to about 87 per cent of the world’s population, including those in the Middle East, Asia, Africa, Europe and Australia.

    Timeline of the dramatic phases

    It begins at 7.28pm GST, when the Moon enters the faint outer edge of Earth’s shadow in what is known as the penumbral phase. The change will be faint at first, but by 8.27pm it will look as though a dark bite has been taken out of the Moon.

    Totality, when the Moon is covered completely by the Earth’s shadow, will take place at 9.30pm, turning the lunar surface a striking shade of red or copper.

    The eclipse reaches its peak at 10.12pm and totality continues until 10.53pm.

    From there, the shadow will gradually recede, until the eclipse has ended just before 1am on Monday. The Moon will spend 82 minutes fully eclipsed, making it one of the longest total lunar eclipses in years.

    Why it happens

    A total lunar eclipse happens when the Sun, Earth and Moon line up perfectly, with the planet casting its shadow across the Moon.

    Instead of disappearing, the Moon takes on a dramatic new look because sunlight bends through Earth’s atmosphere, which filters out the blues and lets the red and orange tones shine, giving it the Blood Moon moniker.

    Where to watch the eclipse

    The eclipse will be visible across all seven emirates, but skywatchers interested in a community experience can observe it with the Dubai Astronomy Group.

    It is hosting a public viewing event at the Mohammed bin Rashid Library from 7pm to 11pm, with tickets priced at Dh250 ($68) for adults and Dh200 for children.

    There will be telescopes and astronomy-themed activities.

    The organisation will also lead a global livestream, in collaboration with observatories and astronomy groups from more than a dozen countries including Spain, Australia, India, Saudi Arabia and Egypt.

    The group is also plans to capture an image of the Moon eclipsed over Burj Khalifa.

    Long wait for the next one

    Those who miss Sunday’s spectacle will have to wait until July 6, 2028, to view another lunar eclipse in the UAE’s skies.

    That will only be a partial eclipse, with a portion of the Moon darkened by the Earth’s shadow. The next total lunar eclipse in the UAE will be on December 31, 2028 – a New Year’s Eve Blood Moon that will last more than five hours.

    What the law says

    Micro-retirement is not a recognised concept or employment status under Federal Decree Law No. 33 of 2021 on the Regulation of Labour Relations (as amended) (UAE Labour Law). As such, it reflects a voluntary work-life balance practice, rather than a recognised legal employment category, according to Dilini Loku, senior associate for law firm Gateley Middle East.

    “Some companies may offer formal sabbatical policies or career break programmes; however, beyond such arrangements, there is no automatic right or statutory entitlement to extended breaks,” she explains.

    “Any leave taken beyond statutory entitlements, such as annual leave, is typically regarded as unpaid leave in accordance with Article 33 of the UAE Labour Law. While employees may legally take unpaid leave, such requests are subject to the employer’s discretion and require approval.”

    If an employee resigns to pursue micro-retirement, the employment contract is terminated, and the employer is under no legal obligation to rehire the employee in the future unless specific contractual agreements are in place (such as return-to-work arrangements), which are generally uncommon, Ms Loku adds.

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  • The NASA Perseverance Rover captured itself landing on Mars and it’s one of the most revealing things you’ll ever see

    NASA didn’t just land a rover on Mars – it filmed the entire nail-biting descent like a cinematic blockbuster.

    The Perseverance rover’s cameras captured every stage: parachute deploying, heat shield dropping away, rocket thrusters firing, and finally the legendary skycrane lowering it onto Martian soil.

    Mission control audio runs over the video, calling out each step in the descent until the words everyone was waiting for: ‘Touchdown confirmed.’

    It’s equal parts science and spectacle – the kind of history-making clip that’ll give you goosebumps.

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  • Lunar ‘Lava Sandwiches’ Could Harbor Earth’s Earliest Biology

    Lunar ‘Lava Sandwiches’ Could Harbor Earth’s Earliest Biology

    Of our Moon’s many remaining secrets, one could be evidence for Earth’s earliest biology in what has been termed a lunar ‘lava sandwich.’

    Finding organics beneath ancient lunar lava, oddly enough, has the potential to usher in a game-changing understanding of life’s origin on Earth. Our own planet’s active geology squelched our ability to retain a full history of the onset of life. But the Moon’s geological record may open a window in time that eludes us here on Earth.

    Records of organic and biological evolution on Earth stopped around 3.8 billion years ago, Mark Sephton, a geochemist at the Royal School of Mines at Imperial College London, tells me in his office. Yet, the Moon may contain older preserved materials that were circulating near to Earth when it was just becoming habitable, Sephton tells me.

    First there would need to be a lava flow from the lunar interior that acts as a bit of lunar asphalt on which an organically, or potentially bio-rich meteorite or planetary fragment would serendipitously fall onto the lunar surface. Then within a relatively short geological time frame — perhaps spanning as little as only tens of millions of years, a second lunar lava flow or eruption would insulate the organic material in a protective ‘lava sandwich.’

    It could literally be almost any spot on the Moon that underwent a lava repaving, says Sephton. The only caveat is that you would have to have some delivery mechanism to the surface of the nascent Moon, so that this meteoritic or planetary material would arrive when the first layer of lava was already down, he says.

    In theory, as Sephton and colleagues noted in a 2015 study, such a lava sandwich could protect this precious trapped material from cosmic ray exposure and/or further degradation for billions of years.

    In other words, such materials may simply be waiting for future robotic probes to find them — potentially either in exposed lunar outcrops or by drilling beneath the surface itself.

    We often talk about the transition from prebiotic to biotic, says Sephton. There is little evidence of this on Earth because of the rock cycle, he notes. But perhaps records of the first chemical steps towards life were ejected into space and then fell onto the Moon, says Sephton.

    In a 2002 paper appearing in the journal ICARUS, the authors note that our Moon may preserve material not only from Earth, but also from Venus. The only attainable record of Venus’ early surface geology, catastrophically erased 700 million years ago, is probably also on the Moon, they write.

    It’d be interesting to see molecules where early life has started to generate molecular machinery that’s working but isn’t quite as efficient as the molecular machinery that we have in our present-day biosphere, says Sephton.

    Are any regions of the Moon particularly good candidates for such samples?

    There are multiple places on the Moon with layered lava flows, Oceanus Procellarum — a large near-side lunar mare — is certainly one, as are other mare regions, Ian Crawford, a planetary scientist at the University of London’s Birkbeck College, tells me via email.

    High-resolution imaging from NASA’s Lunar Reconnaissance Orbiter has also identified many potential localities where layering is exposed in the walls of rilles, craters and collapse pits, he says.

    As for taking an actual sample?

    We would take the samples and liberate organic compounds either by extracting them with organic solvents or by heating (thermal extraction), says Sephton. The latter requires flash heating the sample to fragment the molecules, he says.

    Although it would be cheaper for a potential lava sandwich prospecting mission to perform its own analysis in situ, ideally, such bio-interesting organic samples would best be returned to Earth-based labs.

    Bringing samples back is the best; we’re still benefiting from the rocks that came back from the Moon, says Sephton. The longer these samples are on Earth, the more opportunity for people to come along and say, “I have a new technique; a new type of mineral characterization; a new question,” he says.

    Ancient Lava

    The oldest lava flows will be buried by younger ones so identifying and sampling these may mean drilling down hundreds of meters, which will require quite a lot of infrastructure, so a Moon base would help, says Crawford. But there are other options for paleoregolith preservation in addition to lava flows, he says.

    Case in point, in 1972, Apollo 17 astronaut Harrison ‘Jack’ Schmitt, the only geologist to walk the lunar surface, stumbled across orange and black pyroclastic beads in the Moon’s Taurus Littrow Valley. These kinds of pyroclastic volcanic eruptions could have conceivably cloaked and preserved ancient organics as well.

    The ideal case would be to find a terrestrial meteorite containing organic molecules, or conceivably micro-fossils, from a time that Earth’s own geological record has not preserved, says Crawford.

    ForbesMoon’s Far Side Marks Astronomy’s Final Frontier, Says Big Bang Cosmologist

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  • A Simple Spark That May Explain How Life Began

    A Simple Spark That May Explain How Life Began

    A breakthrough experiment shows how RNA and amino acids might have joined to spark the first steps toward life. (Artist’s concept.) Credit: SciTechDaily.com

    Scientists have recreated a crucial step that may have set life in motion nearly four billion years ago.

    By showing how amino acids, the building blocks of proteins, could spontaneously link with RNA under early Earth conditions, researchers have revealed a potential missing link in biology’s origins.

    Origins of Life’s Building Blocks

    Researchers at UCL have discovered how two essential ingredients of life, RNA (ribonucleic acid) and amino acids, may have naturally combined about four billion years ago at the dawn of life.

    Amino acids are the basic components of proteins, which act as the engines of life and drive nearly every biological function. However, proteins cannot copy themselves or generate instructions for their own production. Those instructions come from RNA, a molecule closely related to DNA (deoxyribonucleic acid).

    Proteins, RNA, and the Blueprint of Life

    In findings published in Nature, the team successfully attached amino acids to RNA under conditions similar to those that might have existed on early Earth. Scientists have been attempting to accomplish this since the early 1970s without success until now.

    Professor Matthew Powner, senior author from UCL’s Department of Chemistry, explained: “Life relies on the ability to synthesize proteins – they are life’s key functional molecules. Understanding the origin of protein synthesis is fundamental to understanding where life came from.

    “Our study is a big step towards this goal, showing how RNA might have first come to control protein synthesis.

    Toward Understanding Protein Synthesis

    “Life today uses an immensely complex molecular machine, the ribosome, to synthesize proteins. This machine requires chemical instructions written in messenger RNA, which carries a gene’s sequence from a cell’s DNA to the ribosome. The ribosome then, like a factory assembly line, reads this RNA and links together amino acids, one by one, to create a protein.

    “We have achieved the first part of that complex process, using very simple chemistry in water at neutral pH to link amino acids to RNA. The chemistry is spontaneous, selective, and could have occurred on the early Earth.”

    Simple Chemistry with Big Implications

    Previous attempts to attach amino acids to RNA used highly reactive molecules, but these broke down in water and caused the amino acids to react with each other, rather than become linked to RNA.

    For the new study, the researchers took inspiration from biology, using a gentler method to convert life’s amino acids into a reactive form. This activation involved a thioester, a high-energy chemical compound important in many of life’s biochemical processes and that has already been theorized to play a role at the start of life.[1]

    Professor Powner said: “Our study unites two prominent origin of life theories – the ‘RNA world’, where self-replicating RNA is proposed to be fundamental, and the ‘thioester world’, in which thioesters are seen as the energy source for the earliest forms of life.”

    Bridging Competing Origin Theories

    To form these thioesters, the amino acids react with a sulfur-bearing compound called pantetheine. Last year, the same team published a paper demonstrating that pantetheine can be synthesized under early Earth-like conditions, suggesting it was likely to play a role in the origin of life.

    The next step, the researchers said, was to determine how RNA sequences could bind preferentially to specific amino acids, allowing RNA to begin coding instructions for protein synthesis—the origin of the genetic code.

    “There are numerous problems to overcome before we can fully elucidate the origin of life, but the most challenging and exciting remains the origins of protein synthesis,” said Professor Powner.

    Lead author Dr. Jyoti Singh, from UCL Chemistry, said: “Imagine the day that chemists might take simple, small molecules, consisting of carbon, nitrogen, hydrogen, oxygen, and sulfur atoms, and from these LEGO pieces form molecules capable of self-replication. This would be a monumental step towards solving the question of life’s origin.

    “Our study brings us closer to that goal by demonstrating how two primordial chemical LEGO pieces (activated amino acids and RNA) could have built peptides,[2] short chains of amino acids that are essential to life.

    “What is particularly groundbreaking is that the activated amino acid used in this study is a thioester, a type of molecule made from Coenzyme A, a chemical found in all living cells. This discovery could potentially link metabolism, the genetic code, and protein building.”

    While the paper focuses solely on the chemistry, the research team said that the reactions they demonstrated could plausibly have taken place in pools or lakes of water on the early Earth (but not likely in the oceans, as the concentrations of the chemicals would likely be too diluted).

    The reactions are too small to see with a visible-light microscope and were tracked using a range of techniques that are used to probe the structure of molecules, including several types of magnetic resonance imaging (which shows how the atoms are arranged) and mass spectrometry (which shows the size of molecules).

    Notes

    1. The Nobel laureate Christian de Duve proposed that life began with a “thioester world” – a metabolism-first theory that envisages life was started by chemical reactions powered by the energy in thioesters.
    2. Peptides typically consist of two to 50 amino acids, while proteins are larger, often containing hundreds or even thousands of amino acids, and are folded into a 3D shape. As part of their study, the research team showed how, once the amino acids were loaded onto the RNA, they could be synthesized with other amino acids to form peptides.

    Reference: “Thioester-mediated RNA aminoacylation and peptidyl-RNA synthesis in water” by Jyoti Singh, Benjamin Thoma, Daniel Whitaker, Max Satterly Webley, Yuan Yao and Matthew W. Powner, 27 August 2025, Nature.
    DOI: 10.1038/s41586-025-09388-y

    The work was funded by the Engineering and Physical Sciences Research Council (EPSRC), the Simons Foundation and the Royal Society.

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