Category: 7. Science

  • NASA looks to self-driving lunar rover decision … – eeNews Europe

    NASA looks to self-driving lunar rover decision … – eeNews Europe

    1. NASA looks to self-driving lunar rover decision …  eeNews Europe
    2. NASA’s Moon Rover Will Hunt for Ice, Map Minerals, and Reveal What Lies Beneath  SciTechDaily
    3. NASA’s new toys for upcoming Artemis mission to map moon’s subsurface, lunar minerals  Interesting Engineering
    4. NASA Names Instruments for Integration Into Artemis Lunar Terrain Vehicle  ExecutiveGov

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  • Could NASA Function Without Elon Musk’s SpaceX?

    Could NASA Function Without Elon Musk’s SpaceX?

    Of all the threats that President Donald Trump and Elon Musk hurled at one another as their alliance fell apart, those targeting Musk’s contracts with the US government have the potential to do the most damage.

    In one sharp exchange triggered by Musk’s criticism of Trump’s signature tax and immigration bill, Trump threatened to cancel federal contracts with the billionaire’s company, SpaceX, that are worth more than $22 billion. Musk said he would decommission the spacecraft SpaceX uses to send supplies and people to the International Space Station, before walking back the statement.

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  • World-first study analyzes minerals on far side of moon

    World-first study analyzes minerals on far side of moon

    A schematic diagram of the soil evolution process in Chang’e 6 lunar samples. [Photo provided to chinadaily.com.cn]

    Shandong University released the world’s first mineralogical ground truth report on magnesium-rich pyroxene annulus from the far side of the moon. The findings, derived from samples returned by China’s Chang’e 6 mission, shed new light on the composition of the South Pole-Aitken Basin, the moon’s largest, deepest, and oldest crater.

    Published in Communications Earth & Environment, a journal under Nature, the study marks a milestone in planetary science.

    Cao Haijun, lead author of the paper and a researcher at Shandong University’s School of Space Science and Physics, described the breakthrough as akin to performing a “deep X-ray scan” of the moon.

    “For the first time, we have obtained high-precision ground truth data from actual samples, revealing previously unknown details about the far side’s interior,” Cao was quoted as saying by Science and Technology Daily.

    The moon’s far side has long been shrouded in mystery, with past studies relying solely on remote sensing due to the lack of physical samples. By employing Raman spectroscopic techniques on mare soil brought back by Chang’e 6, the research team successfully decoded the mineralogical makeup of the SPA Basin’s Mg-pyroxene annulus, learning that it has an abundance of low-calcium pyroxene, a magnesium-dominant mineral.

    The SPA Basin covers nearly one-eighth of the lunar surface. “These findings provide new insights into the origin of SPA mafic anomalies and far side mare soil evolution,” said Cao.

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  • Zebrafish Gene Discovery Aids Hearing Loss Research

    KANSAS CITY, MO — July 14, 2025 — While humans can regularly replace certain cells, like those in our blood and gut, we cannot naturally regrow most other parts of the body. For example, when the tiny sensory hair cells in our inner ears are damaged, the result is often permanent hearing loss, deafness, or balance problems. In contrast, animals like fish, frogs, and chicks regenerate sensory hair cells effortlessly.

    Now, scientists at the Stowers Institute for Medical Research have identified how two distinct genes guide the regeneration of sensory cells in zebrafish. The discovery improves our understanding of how regeneration works in zebrafish and may guide future studies on hearing loss and regenerative medicine in mammals, including humans.

    “Mammals such as ourselves cannot regenerate hair cells in the inner ear,” said Stowers Investigator Tatjana Piotrowski, Ph.D. , the study’s co-author. “As we age or are subjected to prolonged noise exposure, we lose our hearing and balance.”

    New research from the Piotrowski Lab, published in Nature Communications on July 14, 2025, seeks to understand how cell division is regulated to both promote regeneration of hair cells and to also maintain a steady supply of stem cells. Led by former Stowers Researcher Mark Lush, Ph.D., the team discovered that two different genes regulating cell division each control the growth of two key types of sensory support cells in zebrafish. The finding may help scientists study whether similar processes could be triggered in human cells in the future.

    “During normal tissue maintenance and regeneration, cells need to proliferate to replace the cells that are dying or being shed — however, this only works if there are existing cells that can divide to replace them,” said Piotrowski. “To understand how proliferation is regulated, we need to understand how stem cells and their offspring know when to divide and at what point to differentiate.”

    Zebrafish are an excellent system for studying regeneration. Dotted in a straight line from their head to tailfin are sensory organs called neuromasts. Each neuromast resembles a garlic bulb with “hair cells” sprouting from its top. A variety of supporting cells encompass the neuromast to give rise to new hair cells. These sensory cells, which help zebrafish detect water motion, closely resemble those in the human inner ear.

    Because zebrafish are transparent during development and have accessible sensory organ systems, scientists can visualize, as well as genetically sequence and modify, each neuromast cell. This allows them to investigate the mechanisms of stem cell renewal, the proliferation of progenitor cells — direct precursors to hair cells — and hair cell regeneration.

    “We can manipulate genes and test which ones are important for regeneration,” said Piotrowski. “By understanding how these cells regenerate in zebrafish, we hope to identify why similar regeneration does not occur in mammals and whether it might be possible to encourage this process in the future.”

    Two key populations of support cells contribute to regeneration within neuromasts: active stem cells at the neuromast’s edge and progenitor cells near the center. These cells divide symmetrically, which allows the neuromast to continuously make new hair cells while not depleting its stem cells. The team used a sequencing technique to determine which genes were active in each type and found two distinct cyclinD genes present in only one or the other population.

    The researchers then genetically altered each gene in the stem and progenitor populations. They discovered that the different cyclinD genes were independently regulating cell division of the two types of cells.

    “When we rendered one of these genes non-functional, only one population stopped dividing,” said Piotrowski. “This finding shows that different groups of cells within an organ can be controlled separately, which may help scientists understand cell growth in other tissues, such as the intestine or blood.”

    Progenitor cells lacking their cell type-specific cyclinD gene did not proliferate; however, they did form a hair cell, uncoupling cell division with differentiation. Notably, when the stem cell-specific cyclinD gene was engineered to work in progenitor cells, progenitor cell division was restored.

    David Raible, Ph.D., a professor at the University of Washington who studies the zebrafish lateral line sensory system, commented on the significance of the new study. “This work illuminates an elegant mechanism for maintaining neuromast stem cells while promoting hair cell regeneration. It may help us investigate whether similar processes exist or could be activated in mammals.”

    Because cyclinD genes also regulate proliferation in many human cells, like those in the gut and blood, the team’s findings may have implications beyond hair cell regeneration.

    “Insights from zebrafish hair cell regeneration could eventually inform research on other organs and tissues, both those that naturally regenerate and those that do not,” said Piotrowski.

    Additional authors include Ya-Yin Tsai, Shiyuan Chen, Daniela Münch, Julia Peloggia, Ph.D., and Jeremy Sandler, Ph.D.

    This work was funded by the National Institute on Deafness and Other Communication Disorders of the National Institutes of Health (NIH) (award: 1R01DC015488-01A1), the Hearing Health Foundation, and with institutional support from the Stowers Institute for Medical Research. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.

    About the Stowers Institute for Medical Research

    Founded in 1994 through the generosity of Jim Stowers, founder of American Century Investments, and his wife, Virginia, the Stowers Institute for Medical Research is a non-profit, biomedical research organization with a focus on foundational research. Its mission is to expand our understanding of the secrets of life and improve life’s quality through innovative approaches to the causes, treatment, and prevention of diseases.

    The Institute consists of 20 independent research programs. Of the approximately 500 members, over 370 are scientific staff that include principal investigators, technology center directors, postdoctoral scientists, graduate students, and technical support staff. Learn more about the Institute at www.stowers.org and about its graduate program at www.stowers.org/gradschool .

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  • Astronomers Spot Giant Hidden in Young Star’s Fog

    Astronomers Spot Giant Hidden in Young Star’s Fog

    Astronomers have detected a giant exoplanet – between three and ten times the size of Jupiter – hiding in the swirling disc of gas and dust surrounding a young star.

    Earlier observations of this star, called MP Mus, suggested that it was all alone without any planets in orbit around it, surrounded by a featureless cloud of gas and dust.

    However, a second look at MP Mus, using a combination of results from the Atacama Large Millimeter/submillimeter Array (ALMA) and the European Space Agency’s Gaia mission, suggest that the star is not alone after all.

    The international team of astronomers, led by the University of Cambridge, detected a large gas giant in the star’s protoplanetary disc: the pancake-like cloud of gases, dust and ice where the process of planet formation begins. This is the first time that Gaia has detected an exoplanet within a protoplanetary disc. The results, reported in the journal Nature Astronomy, suggest that similar methods could be useful in the hunt for young planets around other stars.

    By studying how planets form in the protoplanetary discs around young stars, researchers can learn more about how our own Solar System evolved. Through a process known as core accretion, gravity causes particles in the disc to stick to each other, eventually forming larger solid bodies like asteroids or planets. As young planets form, they start to carve gaps in the disc, like grooves on a vinyl record.

    However, observing these young planets is extremely challenging, due to the interference from the gas and dust in the disc. To date, only three robust detections of young planets in a protoplanetary disc have been made.

    Dr Álvaro Ribas from Cambridge’s Institute of Astronomy, who led the research, specialises in studying protoplanetary discs. “We first observed this star at the time when we learned that most discs have rings and gaps, and I was hoping to find features around MP Mus that could hint at the presence of a planet or planets,” he said.

    Using ALMA, Ribas observed the protoplanetary disc around MP Mus (PDS 66) in 2023. The results showed a young star seemingly all alone in the universe. Its surrounding disc showed none of the gaps where planets might be forming, and was completely flat and featureless.

    “Our earlier observations showed a boring, flat disc,” said Ribas. “But this seemed odd to us, since the disc is between seven and ten million years old. In a disc of that age, we would expect to see some evidence of planet formation.”

    Now, Ribas and his colleagues from Germany, Chile, and France have given MP Mus another chance. Once again using ALMA, they observed the star at the 3mm range, a longer wavelength than the earlier observations, allowing them to probe deeper into the disc.

    The new observations turned up a cavity close to the star and two gaps further out, which were obscured in the earlier observations, suggesting that MP Mus may not be alone after all.

    At the same time, Miguel Vioque, a researcher at the European Southern Observatory, was uncovering another piece of the puzzle. Using data from Gaia, he found MP Mus was ‘wobbling’.

    “My first reaction was that I must have made a mistake in my calculations, because MP Mus was known to have a featureless disc,” said Vioque. “I was revising my calculations when I saw Álvaro give a talk presenting preliminary results of a newly-discovered inner cavity in the disc, which meant the wobbling I was detecting was real and had a good chance of being caused by a forming planet.”

    Using a combination of the Gaia and ALMA observations, along with some computer modelling, the researchers say the wobbling is likely caused by a gas giant – less than ten times the mass of Jupiter – orbiting the star at a distance between one and three times the distance of the Earth to the Sun.

    “Our modelling work showed that if you put a giant planet inside the new-found cavity, you can also explain the Gaia signal,” said Ribas. “And using the longer ALMA wavelengths allowed us to see structures we couldn’t see before.”

    This is the first time an exoplanet embedded in a protoplanetary disc has been indirectly discovered in this way – by combining precise star movement data from the Gaia with deep observations of the disc. It also means that many more hidden planets might exist in other discs, just waiting to be found.

    “We think this might be one of the reasons why it’s hard to detect young planets in protoplanetary discs, because in this case, we needed the ALMA and Gaia data together,” said Ribas. “The longer ALMA wavelength is incredibly useful, but to observe at this wavelength requires more time on the telescope.”

    Ribas says that upcoming upgrades to ALMA, as well as future telescopes such as the next generation Very Large Array (ngVLA), may be used to look deeper into more discs and better understand the hidden population of young planets, which could in turn help us learn how our own planet may have formed.

    The research was supported in part by the European Union’s Horizon Programme, the European Research Council, and the UK Science and Technology Facilities Council (STFC), part of UK Research and Innovation (UKRI).

    /Public Release. This material from the originating organization/author(s) might be of the point-in-time nature, and edited for clarity, style and length. Mirage.News does not take institutional positions or sides, and all views, positions, and conclusions expressed herein are solely those of the author(s).View in full here.

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  • The Structure of Ice in Space Is Neither Order nor Chaos—It’s Both

    The Structure of Ice in Space Is Neither Order nor Chaos—It’s Both

    Ice is a key component in the universe. There are frozen water molecules on comets, moons, exoplanets, and in your drink as you cool off from the summer heat. However, under the microscope, not all ice is the same, even though it is made of the same components.

    The internal structure of Earth’s ice is a cosmological oddity. Its molecules are arranged in geometric structures, usually hexagons that repeat each other. Ice on Earth forms this way due to the temperature and pressure of the our planet: water here freezes slowly, and this allows its molecules to arrange themselves into crystals.

    But ice that forms in space is different because of the conditions—the water exists in a vacuum and is subject to extreme temperatures. Space ice, as a result, is believed to be amorphous, lacking a distinct organizational structure like on Earth.

    An illustration of the ordered molecular structure of water ice on Earth.

    GETTY IMAGES

    This presents a challenge for scientists trying to understand the formation of planets and the generation of life. Not fully understanding the dynamics of amorphous ice in space has knock-on effects. For instance, not knowing exactly how space water freezes makes it difficult to estimate the proportion of water in other solar systems.

    Researchers are therefore studying space ice to gain a better understanding of how frozen water behaves away from Earth. Ice samples from comets, asteroids, and other solar system debris would be helpful, but until these can be captured, scientists are trying to understand space ice with computer models and simulations of ice on Earth. The more they study it, the more surprises it reveals.

    A recent report, published in the journal Physical Review B, posits that the amorphous ice that abounds in the universe does have some kind of order. The paper theorizes it is likely made up of structured fragments—crystallized regions, as on Earth, but only about 3 nanometers wide—surrounded by chaos.

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  • Can your brain run out of memory?

    Can your brain run out of memory?

    You can use up all the storage on your phone or max out your computer’s drive, but can you use up all the memory space in your brain?

    Despite how you might feel before an exam or after a sleepless night before a work deadline, neuroscientists say that for a typical, healthy brain, memory capacity isn’t fixed or easily used up.

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  • Erosion Points the Way for Rivers

    Erosion Points the Way for Rivers

    Rivers are Earth’s arteries. Water, sediment and nutrients self-organize into diverse, dynamic channels as they journey from the mountains to the sea. Some rivers carve out a single pathway, while others divide into multiple interwoven threads. These channel patterns shape flood risks, erosion hazards and ecosystem services for more than three billion people who live along river corridors worldwide.

    Understanding why some waterways form single channels, while others divide into many threads, has perplexed researchers for over a century. Geographers at UC Santa Barbara mapped the thread dynamics along 84 rivers with 36 years of global satellite imagery to determine what dictates this aspect of river behavior.

    “We found that rivers will develop multiple channels if they erode their banks faster than they deposit sediment on their opposing banks. This causes a channel to widen and divide over time,” said lead author Austin Chadwick, who conducted this study as a postdoctoral researcher at UCSB.

    The results, published in the journal Science, solve a longstanding quandary in the science of rivers. They also provide insight into natural hazards and river restoration efforts.

    Two types of rivers

    Earth scientists have long divided rivers into single and multi-channel categories, and generally investigate the two separately. While neither type clearly outnumbers the other, most of the world’s largest rivers are multi-channeled. The notable exception is the single-channel Mississippi River, in the United States, where a lot of river research has occurred.

    Most field research has focused on single-threaded rivers, partly because they’re simpler. Meanwhile, experimental work has focused on multi-threaded rivers due to the challenges of recreating single-threaded channels in laboratory tank experiments.

    It was while working on one of these tank experiments at University of Minnesota’s St. Anthony Falls Laboratory that Chadwick got the inspiration for this study. While examining multi-channel rivers in the lab, he noticed that they were constantly widening and splitting. “I was banging my head on the wall because I kept measuring more erosion than deposition. And that was not what we’re taught in school,” he recalled. “That led me to read some old books from the Army Corps and other sources about examples where there’s more bank erosion than deposition.” Eventually, he became curious whether this occurred in nature.

    It was a classic example of the scientific method: “You generate a hypothesis in a laboratory setting and then you’re able to test it in nature,” said co-author Evan Greenberg, a former doctoral student at UCSB who received the prestigious Lancaster Award for best dissertation.

    Long-term data at 2,300,000 feet

    The team leveraged Landsat data housed at the Google Earth Engine repository, focusing on 84 rivers in different regions of the globe. They tracked erosion and deposition on each river’s banks using an image-processing algorithm called particle image velocimetry. The authors adapted this algorithm — originally designed to track particle motion in lab photos of a fluid — to track channel position in satellite images of their floodplains.

    In single-threaded rivers, erosion and deposition balanced out. As a result, the channel’s width remains constant, allowing these rivers to lean into their bends and form wide, meandering paths across the landscape. In contrast, bank erosion outpaced deposition in multi-channel rivers, causing a given channel to widen over time until it splits in two. As a result, multi-channel rivers reshuffle their channels before they can meander too far across the floodplain.

    Each of these dynamics occurs while a river is in a steady state (neither growing nor shrinking). “It is not like multi-threaded rivers are gaining water on average. They are still conveying the same amount of water through time, but they are doing that by constantly shuffling the size of the individual threads,” explained senior author Vamsi Ganti, an associate professor of geography at UCSB.

    When the authors say that erosion exceeds deposition, they’re referring to the river’s banks. For multi-channel rivers, the extra sediment eroded from the banks is redeposited on the river bottom, eventually forming the islands and bars that separate the different channels.

    Rivers can follow one of two trajectories depending on the balance between bank erosion and deposition.

    The researchers tallied a few exceptions to the erosion-deposition trend, but they discovered that each of them coincided with apparent changes in the watershed that forced the river out of its natural steady state. For instance, the Sao Francisco River in Brazil didn’t exhibit excess erosion like other multi-channel rivers because the river has been shrinking in response to the damming of its headwaters and water extraction for irrigation.

    “The question of what causes a river to be single-threaded or multi-threaded is pretty much as old as the field of geomorphology,” said Ganti.

    Generally, geographers have understood river dynamics in terms of myriad variables, including downstream slope, water flow rate, sediment type and bank stability. The new model explains river type solely in terms of the balance between deposition and erosion. The various geographic factors affect this balance, explaining why specific environments tend to favor certain kinds of rivers.

    Giving rivers space to flow

    The 20th century has seen many rivers boxed into narrow channels disconnected from their historic floodplains. This reclaims more land for settlement and mitigates some of the inherent hazards of living near a river. However, this is disastrous for riparian ecosystems and can even exacerbate long-term hazards. Cutting a river from its floodplain means sediment settles on the riverbed, elevating the river relative to the neighboring, sediment-starved floodplain. This makes it more likely to jump its banks in the event of a flood or a levee failure, a phenomenon the team has investigated in depth.

    “Consider Hurricane Katrina,” Chadwick said. “When the levee broke, there was widespread flooding in part because the floodplain had been cut off from the Mississippi for so long that it had sunk relative to the river, allowing the floodwaters to pond there.”

    There’s a growing effort to reconnect channelized rivers with their floodplains and give them more space to move. Nature-based restoration efforts require figuring out how wide a corridor a given river needs in order to return to its natural state, as well as how long it will take to do so. With their newfound understanding of river dynamics, the team devised a formula for this, which includes variables like how long a river takes to abandon a channel. The formula also describes whether a river returns to a single- or multi-channel state. They calculated the restoration widths and times for various types of rivers based on their satellite observations.

    Vamsi Ganti’s research seeks to quantify and understand the mechanics of physical processes that shape the landscapes on Earth and other planets, and to unravel the expression of these processes in the ancient sedimentary record. He works on a range…

    Chadwick, Ganti and Greenberg found that the time and space a river needs to reestablish its natural behavior varied widely between single and multi-threaded rivers. A single-threaded river requires about ten times more space and time to reestablish itself as a multi-threaded river of the same stream power, which is the amount of energy the stream has to erode and move sediment.

    The paper’s insights can guide infrastructure and revitalization projects. The formula developed by the authors enables engineers and scientists to estimate the width a restoration project will need, a deciding factor in a project’s feasibility and cost. The analysis can also help policymakers prioritize candidates for recovery. Research, restoration and hazard mitigation have historically focused on single-threaded channels, but shifting toward projects on multi-threaded waterways could yield greater returns for lower costs.

    In fact, the team’s findings suggest that river restoration may be less costly than anticipated. There’s growing recognition that many single-threaded rivers were historically multi-threaded before human intervention, especially in the western U.S. For instance, photos of the Los Angeles River from the 1930s, before it was channelized, show it with multiple threads. A project currently considered prohibitively large or expensive may actually be affordable if a river was misclassified, Chadwick explained.

    Ganti’s lab is currently studying the acceleration and deceleration of rivers, as well as changes in the number of threads a river has over time. “These temporal trends are likely signatures of how climate change and human interference are affecting river dynamics,” he said.

    Chadwick is still curious why erosion outpaces deposition in some rivers. He plans to further investigate the diversity of multi-threaded rivers as a postdoctoral research scientist at Columbia University’s Lamont-Doherty Earth Observatory, with a particular interest in how they form. Meanwhile, Greenberg, now at the Jet Propulsion Laboratory (JPL), is using remote sensing to measure sediment transport in rivers. He’s also finishing up work looking at how dams influence river shape over time and the development of the river corridor.

    Rivers have played an important role in human history. They irrigate the crops we grow on their fertile plains and convey our goods to and fro. But they also flood our cities and suddenly forsake well-worn channels. Learning more about rivers will enable us to better coexist with these mercurial natural features in a time of unprecedented change.

    Reference: Chadwick AJ, Greenberg E, Ganti V. Single- and multithread rivers originate from (im)balance between lateral erosion and accretion. Science. 2025. doi:10.1126/science.ads6567


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  • This shark can change colour from blue to green and even gold, study finds

    This shark can change colour from blue to green and even gold, study finds

    The first time you see a blue shark in the water, it’s almost impossible not to be taken aback by just how… well, blue they are. Now, scientists have uncovered the secret to their vivid azure hue and discovered that these animals might also be able to change colour. 

    Blue sharks (Prionace glauca) have special crystals inside their scales that create their distinctive shade and may also give them chameleon-like abilities, according to research presented at the Society for Experimental Biology Annual Conference.

    How blue sharks change colour

    “Blue is one of the rarest colours in the animal kingdom,” says Dr. Viktoriia Kamska, City University of Hong Kong, in a statement. “Animals have developed a variety of unique strategies through evolution to produce it, making these processes especially fascinating.”

    The blue shark’s strategy? Special crystals inside the tooth-like scales (known as dermal denticles) that these animals have covering their bodies. 

    Derman denticles have pulp-like cavities and, inside these, are guanine crystals, which reflect blue light, and tiny sacs that store melanin (a natural pigment that give skin, hair and eyes their colour), which absorb other wavelengths of light. 

    “These components are packed into separate cells, reminiscent of bags filled with mirrors and bags with black absorbers, but kept in close association so they work together,” says Kamska. 

    Blue shark dermal denticles. Credit: Dr Viktoriia Kamska

    The scientists used a combination of advanced technologies to figure out how these tiny structures worked to create the shark’s vibrant colour.

    “When you combine these materials together, you also create a powerful ability to produce and change colour,” says Professor Mason Dean. “What’s fascinating is that we can observe tiny changes in the cells containing the crystals and see and model how they influence the colour of the whole organism.”

    It’s incredibly difficult to tweak the tiny structures themselves to test different scenarios so they also turned to computer simulations to see what happened when different wavelengths of light were introduced. 

    As well as uncovering how the shark creates its bold blue colouring, the experts also realised that it might have the ability to change hues, like a chameleon. When the crystals move closer together, the shark appears its classic blue colour, and when they drift further apart, its skin is tinted with greens and golds. 

    This could help the animal stay camouflaged in changing environmental conditions. “In this way, very fine scale alterations resulting from something as simple as humidity or water pressure changes could alter body colour,” says Professor Dean. These “then shape how the animal camouflages or counter-shades in its natural environment.” 

    In deeper, darker water, the pressure might push the nanocrystals together more closely and so the shark would turn a darker blue – helping it blend in more seamlessly with its surroundings.  

    The researchers now want to see how their hypothesis plays out in the wild – can they observe this happening among blue sharks in their natural habitat?

    They’re also curious how the understanding of this mechanism might benefit humans by inspiring ways of creating a blue colour without using potentially harmful chemicals. “A major benefit of structural colouration over chemical colouration is that it reduces the toxicity of materials and reduces environmental pollution,” says Kamska.  

    Sharks aren’t the only marine animals that have remarkable colour changing abilities. Cephalopods such as octopus, cuttlefish and squid can alter their colour and pattern in the blink of an eye – sometimes even sending messages through the displays that flash up on their skin.

    Even seahorses can blend into their surroundings to hide from potential danger. They are able to do this thanks to tiny balloon-like pouches within their skin called chromatophores. These are filled with pigment and can rapidly grow or shrink to change the animal’s appearance. 

    Studying how blue sharks (and perhaps other species, including great whites which may be able to change their shade to creep up on prey without detection) create their colour could give researchers exciting new insights. 

    “We know a lot about how other fishes make colours, but sharks and rays diverged from bony fishes hundreds of millions of years ago,” says Professor Dean, “so this represents a completely different evolutionary path for making colour.”

    Top image: blue shark. Credit: Getty

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  • Antibody Mapping With Microchip Tech Speeds Vaccine Design

    Antibody Mapping With Microchip Tech Speeds Vaccine Design


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    A new microchip invented by Scripps Research scientists can reveal how a person’s antibodies interact with viruses—using just a drop of blood. The technology offers researchers faster, clearer insights that could help accelerate vaccine development and antibody discovery.

    “This lets us take a quick snapshot of antibodies as they are evolving after a vaccine or pathogen exposure,” says Andrew Ward, professor in the Department of Integrative Structural and Computational Biology at Scripps Research and senior author of the new paper published in Nature Biomedical Engineering on June 3, 2025. “We’ve never been able to do that on this timescale or with such tiny amounts of blood before.”

    When someone is infected with a virus, or receives a vaccine, their immune system creates new antibodies to recognize the foreign invader. Some antibodies work well against the pathogen, while others attach to it only weakly. Figuring out exactly which parts of the virus the best antibodies stick to is key information for scientists trying to optimize vaccines, since they want to design vaccines that elicit strong, reliable immune responses.

    “If we know which particular antibodies are leading to the most protective response against a virus, then we can go and engineer new vaccines that elicit those antibodies,” says Leigh Sewall, a graduate student at Scripps Research and first author of the new paper.

    In 2018, Ward’s lab unveiled a technique known as electron microscopy-based polyclonal epitope mapping (EMPEM). This method allowed scientists to visualize how antibodies in blood samples attach to a virus. Although groundbreaking, it had downsides: it took a full week to complete and required relatively large amounts of blood.

    “During the COVID-19 pandemic, we began really wanting a way to do this faster,” says Alba Torrents de la Peña, a Scripps Research staff scientist who helped lead the work. “We decided to design something from scratch.”

    With the new system, known as microfluidic EM-based polyclonal epitope mapping (mEM), researchers start with four microliters of blood extracted from a human or animal–about one hundred times less than what’s required in original EMPEM. The blood is injected in a tiny, reusable chip where viral proteins are stuck to a special surface. As the blood flow through the chip, antibodies recognize and bind to those. Then, the viral proteins—with any antibodies attached—are gently released from the chip and prepared for imaging using standard electron microscopy. The entire process only takes about 90 minutes.

    To test the value and effectiveness of mEM, the research team used the system to map antibodies in humans and mice that had either received a vaccination against or been infected with a virus, including influenza, SARS-CoV-2 and HIV. The new technique was not only fast at mapping out the interactions between antibodies and those viruses, but more sensitive than EMPEM; it revealed new antibody binding sites on both influenza and coronavirus proteins that had not been picked up by EMPEM.

    To track how antibodies evolved over time in individual mice after they received a vaccination against one of the pathogens, the team took small blood samples from a mouse at different time points.

    “That was something that wouldn’t have been possible in the past, because of the amount of blood needed for EMPEM,” says Sewall. “So to be able to look at an individual over time was really exciting.”

    The researchers are now working to automate and multiplex the system, which could eventually allow dozens of samples to be processed in parallel. Ultimately, they envision mEM becoming a widely adopted tool to monitor and guide vaccine development in pathogens ranging from coronaviruses to malaria.

    “This technology is useful in any situation where you have really limited sample volume, or need initial results quickly,” says Torrents de la Peña. “We hope this becomes accessible to more researchers as it is simplified and streamlined.”

    Reference: Sewall LM, de Paiva Froes Rocha R, Gibson G, et al. Microfluidics combined with electron microscopy for rapid and high-throughput mapping of antibody–viral glycoprotein complexes. Nat Biomed Eng. 2025. doi: 10.1038/s41551-025-01411-x

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