Category: 4. Technology

By optimizing potency, pharmacokinetics and safety simultaneously, it enables high quality compounds with balanced biological and physicochemical properties to be identified.

Key highlights of the poster include:

• The use of multi-parameter optimization scoring as a decision-making tool
• How the multi-parameter optimization scoring is updated as the project advances through drug discovery
• Incorporation of considerations such as target tissue, administration route and safety liabilities at an early stage to drive design

Epic Games Inc. settled its antitrust case against Samsung Electronics Co. that alleged the company was conspiring with Alphabet Inc.’s Google to block rival app marketplaces through default settings on mobile devices sold by the electronics giant.

In a brief court filing Monday, the maker of the blockbuster shooter game Fortnite dismissed all of the antitrust claims against Samsung and Google. Google remains a defendant on several non-antitrust claims.

Apple is making another attempt to appeal the trade ban that forced it to remove the blood oxygen sensor from its smartwatches, Reuters reports. The company was forced to remove the feature in 2024, following a decision from the International Trade Commission (ITC) in 2023 that banned sales of the Apple Watch for violating health tech startup Masimo’s patents.

The US Court of Appeals for the Federal Circuit heard new arguments from Apple and Masimo’s lawyers on Monday over the legality of the original ITC ban. Apple’s argument is that the fact Masimo was developing its own smartwatch when Apple released the Apple Watch Series 6 in 2020 — the first of the company’s wearables with a blood oxygen sensor — shouldn’t be enough to justify the ban. Masimo disagrees.

The appeals court has heard the company’s arguments before, and even briefly paused the trade ban in December 2023 while the ITC considered Apple’s request for a longer pause. Ultimately, the ITC ruled in Masimo’s favor and denied Apple’s request. Apple removed the blood oxygen sensor in 2024 so it could restart sales of the Apple Watch Series 9 and Apple Watch Ultra 2 in the US.

The companies’ fight goes beyond just the blood oxygen sensor — Masimo’s smartwatches were, ironically, found to infringe on Apple patents — but clearly Apple is hung up on the feature. The company’s blood oxygen sensor was never as accurate as the pulse oximeters used in a doctor’s office, but it was part of a fairly comprehensive suite of heart health features on the smartwatch. It’s entirely possible Apple wants to reintroduce it in its watches as part of an even more ambitious health feature down the road.

Porsche just unveiled a love letter to its most diehard 911 fans in America in the form of the 911 Club Coupe, a limited-edition model for enthusiasts who want more tartan and flat-six in their lives. The marque debuted the car this weekend in Oklahoma City at a meeting of the Porsche Club of America.

The 911 Club Coupe is powered by a 388-horsepower flat-six, in fact, paired with a six-speed manual transmission that is controlled by a shift lever made of walnut. The ride height is 10 millimeters lower than a regular 911 Carrera, Porsche says, thanks to a suspension upgrade.

The car is painted in a blue hue called Paint to Sample Sholar Blue, named for the PCA’s founder Bill Sholar; a version of the color was first used in 2015 on the second Club Coupe. Inside, the 911 Club Coupe has red seat belts, black leather, and a door projector with the Porsche Club of America’s logo. Tartan fabric in a specific stitching pattern adorning the seat centers is optional, including in the glove compartment. The car’s key is colored Sholar Blue, too, and has a leather key pouch for safekeeping.

The car is based on the 911 Carrera T and has various mechanical upgrades to improve it but at its core, it is still a lightweight driver’s car, as the 911 Carrera T is intended to be and as PCA members surely enjoy.

“PCA members are some of the most passionate, not just in our little world but across the auto industry in general,” Timo Resch, president of Porsche North America, said in a statement.

The Porsche Club of America was founded 70 years ago, and Porsche says it’s the largest club of its type in the world. One of its main events is the Porsche Parade, which is held in different cities each year, including Birmingham, Alabama, in 2024, and Palm Springs, California, in 2023.

Porsche made the first Club Coupe in 2005 for the PCA’s 50th anniversary. The model appeared at the Porsche Parade in Hershey, Pennsylvania, that year; the first example of that car now sits in the Porsche Museum. The second Club Coupe debuted in 2015 for the PCA’s 60th anniversary and appeared at the Porsche Parade in French Lick, Indiana.

The first example of this third one will also go to the Porsche Museum, with the rest being offered for sale to PCA members first. Porsche did not give pricing information, but the 911 Carrera T starts at $138,700, and the 911 Club Coupe will be more.

Click here for more photos of the Porsche 911 Club Coupe.

Although BMW has just recently introduced an all-new generation of the BMW M5 under the G60 chassis code, the Bavarian automaker is in the process of entirely overhauling its product lineup, how it plans on building its vehicles, and what kind of propulsion methods will power them. Under the Neue Klasse theme, BMW aims to launch a full battalion of next-generation sedans and SUVs in the coming years, blending both internal combustion engines (ICEs), hybrids, and fully electric vehicles (EVs). And the 5 Series will be the first model at BMW to showcase this to the entire world.

What does all of this mean for the almighty M5? It’s quite unlikely that it’ll also be overhauled when Neue Klass arrives next year, given how young the G60 still is. But it’ll most certainly receive a very important facelift as well to align itself with the rest of BMW’s models, including an entirely new face inspired by these Neue Klasse vehicles. Our latest spy shots confirm this, revealing just how close to production we already are to a facelifted G60 M5.

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Will The Facelifted BMW M5 Still Weigh More Than A Ford F-150?

The biggest controversy surrounding the current BMW M5 is its excessive curb weight. Weighing at a stonking 5,200 pounds – which is more than a Ford F-150 (4,300 lbs) – the G60 M5 is the result of trying to cram V-8 power, all-wheel-drive, and plug-in-hybrid (PHEV) technology into a single car. It’s unclear if the facelifted model will attempt to do something about all that heft.

But the current M5 is also extremely powerful. The total combined output is rated by the automaker at 717 horsepower and 738 pound-feet of torque, allowing this behemoth of a super sedan to hit 0 to 60 MPH in three seconds flat and cover the quarter-mile in just under 11 seconds. When it’s not busy hunting Lamborghinis on Germany’s Autobahn, the new M5 can also casually run daily errands in fully electric mode, offering up to 20 miles of range when its 15-kWh lithium-ion battery is fully juiced up.

This duality is what has always characterized the M5. It’s this ability to both be a supercar-slaying machine and an understated, quiet, refined, and comfortable luxury midsize sedan, a car that flies under most people’s radar, that has always allowed it to shine brighter than other sport sedans. Only the wider fender flares, quad-tip exhaust pipes, and massive brakes reveal that this is no ordinary BMW 5 Series.

The Facelifted BMW M5 Will Most Likely Arrive In 2027

We don’t know if BMW plans on changing anything about the M5’s PHEV powerplant, even if there has been a lot of backlash surrounding it. But these spy shots do at least reveal the expected M5 qualities: wide fender flares, big wheels and brakes, and a set of four missile silos out the rear, acting as exhaust pipes.

This presumably confirms that the twin-turbocharged, 4.4-liter V-8 will still sit underneath the car’s hood. But these spy shots also reveal an entirely new front fascia, inspired by the Neue Klasse concepts. So, similarly to what we’ve seen with past M5s, this could simply be the same car we already know from a mechanical standpoint, but simply with an updated face and some minor interior tweaks.

But the update could also give the M5 refreshed Neue Klasse battery technology. One of the big highlights of that architecture will be its efficiency in the EV space, allowing BMW to manufacture batteries at much higher energy densities, efficiency, range, and charging capability. The facelifted M5 could inherit some of that technological know-how, which could lead to a lighter battery and electric powertrain, resulting in a lower overall curb weight. It’s all speculation at this point. But an updated BMW M5 is coming soon.

Stop Killing Games, a consumer movement designed to bring attention to the depreciation of online media, has gathered enough momentum to necessitate a response from “the voice of a responsible games ecosystem,” Video Games Europe.

“An increasing number of video games are sold effectively as goods – with no stated expiration date – but designed to be completely unplayable as soon as support from the publisher ends,” the Stop Killing Games website states (thanks, PC Gamer). “This practice is a form of planned obsolescence and is not only detrimental to customers, but makes preservation effectively impossible. Furthermore, the legality of this practice is largely untested in many countries.”

Having now amassed over one million signatures in the “European Citizens’ Initiative” – although, as PCG posits, there is some question over the validity of some signatories – Video Games Europe has provided a statement.

“We appreciate the passion of our community; however, the decision to discontinue online services is multi-faceted, never taken lightly, and must be an option for companies when an online experience is no longer commercially viable,” the organization said. “We understand that it can be disappointing for players but, when it does happen, the industry ensures that players are given fair notice of the prospective changes in compliance with local consumer protection laws.

“Private servers are not always a viable alternative option for players as the protections we put in place to secure players’ data, remove illegal content, and combat unsafe community content would not exist and would leave rights holders liable. In addition, many titles are designed from the ground-up to be online-only; in effect, these proposals would curtail developer choice by making these video games prohibitively expensive to create.

“We welcome the opportunity to discuss our position with policymakers and those who have led the European Citizens Initiative in the coming months.”

A similar UK petition hit 10,000 signatories in February, at which point the UK Government was obliged to respond. However, while the UK Government said it “recognize[d] concerns raised by video games users regarding the operability of purchased products” and “are aware of issues relating to the life-span of digital content, including video games,” it has “no plans to amend existing consumer law on digital obsolescence.” It did, however, promise to monitor the issue via the Competition and Market Authority (CMA).

Since then, however, the petition has topped 170,000 signatories. It will now be tabled for debate in the UK Parliament.

The Xbox division at Microsoft is reportedly going through a difficult period, beset with layoffs and, perhaps more surprisingly, financial targets that could be detrimental to its long-term health, according to insiders. This is reportedly due to increasing pressure from above. Xbox has been given an “utterly unrealistic financial target,” which could impede the division.

Windows Central’s Jez Corden reported the insider scoop on X, where he stated that Microsoft’s CFO Amy Hood had given the Xbox division an “utterly unrealistic” financial target. Corden added that the expectations could “continue hurting the division.” This news comes in the wake of a massive round of layoffs at Microsoft, which have hit Xbox and its studios pretty hard.

The Verge’s Tom Warren joined the conversation and pushed back on the “unrealistic” label, stating, “I don’t think it’s unrealistic, it’s just the reality of the Xbox business after the ABK acquisition. Without that deal, Xbox revenue would be down, and the Game Pass gamble hasn’t paid off yet.”

The acquisition in question is Microsoft’s $68.7 billion procurement of Activision Blizzard, which supercharged the company’s portfolio with IPs such as World of Warcraft, Diablo, DOOM, and Call of Duty. 

To put things into perspective, Microsoft’s total revenue for the fiscal year of 2022 was $198.27 billion, with the Xbox division contributing only $16.23 billion in the same period. In 2024, Microsoft’s Xbox revenue was $15.7 billion, a steep decline from the previous fiscal year’s $21.5 billion. Insiders believe that the decline is due to fewer Xbox hardware sales, as Microsoft sold only 2.7 million units while Sony sold 4 million PS5 units in the same year.

Xbox Game Pass, meanwhile, hit 34 million subscribers in early 2024. As of mid-2025, it’s reported that the subscription service has signed up more than 35 million subscribers. This is well below Microsoft’s goal of hitting 100 million users by 2030.

While Game Pass generated $4.7 billion in revenue in 2024 and is projected to generate around $5.5 billion by 2025, the growth is not expected to offset the broader financial investments made by Microsoft.

It’s apparent that financial pressures have been severe, considering Microsoft laid off 9,100 employees, affecting AAA studios: Turn 10, Rare, Romero Games, and The Initiative.

Xbox Game Studios is undergoing an aggressive restructuring period, and the road ahead seems anything but smooth. The tremors from the aftermath of the layoffs have been felt throughout the gaming industry and are also visible on LinkedIn where former employees have announced that they were laid off, often unexpectedly.

There are many things to think about when picking the right TV for you, such as brand, screen size and, most importantly, price. Especially with tariffs on the rise, looking for a way to save some coin is always a smart idea. Thankfully, Prime Day sales officially start tomorrow, giving shoppers tons of deals on items like TVs. But if you can’t wait, there are some deals available now.

Right now on Amazon, you can score the Hisense U6 75-inch TV for only $494. This is a savings of almost $100. This is the lowest price we’ve seen for this TV yet. This 75-inch model can work well for a living room or home theater, perfect for all your summer movie marathons. Just note that we don’t know how long this deal will last since Prime Day kicks off tomorrow, so we suggest taking advantage of it now before it’s too late.  

This Hisense U6 TV delivers a high-quality picture to make anything you watch look its best. The TV also features Hisense’s exclusive ULED display. It boasts up to 600 nits of peak brightness, a 60Hz refresh rate and Dolby Vision HDR 10. It runs on Amazon’s Fire TV OS, so you can stream anything you’d like. 

And with the Alexa voice remote, you can have a completely hands-free experience. For the gamers, the built-in gaming mode helps minimize input lag, so you won’t miss even a moment of your game.

Not really what you’re looking for? No worries, there are plenty of other Prime Day TV sales you can start shopping right now. 

Why this deal matters

We’re definitely going to be seeing many TVs on sale for Prime Day, but this Hisense TV is at a record-low price right now. There’s no guarantee it will return to this price, so we suggest taking advantage of it now if this TV meets your needs and budget.