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  • Meeting highlights from the Committee for Veterinary Medicinal Products (CVMP) 9-10 September 2025

    CVMP opinions on veterinary medicinal products

    The Committee adopted, by majority, a positive opinion for a marketing authorisation from Zoetis Belgium for Portela (relfovetmab), for the alleviation of pain associated with osteoarthritis in cats.

    The Committee adopted, by consensus, a positive opinion for a variation requiring assessment for Divence Tetra (Bovine viral diarrhoea (subunit), bovine parainfluenza 3 virus (inactivated)) to implement the outcome of the MAH’s signal management process to add new, uncommon adverse events in the product information: milk production decrease, reduced food intake and decreased activity. Information on allowing the vaccine to reach room temperature before use was also added to the product information.

    The Committee adopted, by consensus, a positive opinion for a variation requiring assessment for Bravecto TriUNO (fluralaner/ moxidectin/ pyrantel) concerning change(s) to therapeutic indication(s) – addition of a new therapeutic indication or modification of an approved one: for the treatment of infections with Angiostrongylus vasorum. Additionally, the product information has been aligned with version 9.1 of the QRD template.

    The Committee adopted, by consensus, positive opinions for variations requiring assessment concerning quality-related changes for:

    • Arthricox
    • BTVPUR
    • Credelio, Lotimax, AdTab, Credelio Plus (worksharing procedure)
    • Cytopoint
    • Draxxin
    • Easotic
    • Emevet
    • Equilis Te, Equilis Prequenza Te (worksharing procedure)
    • Equioxx
    • Felpreva
    • ProZinc
    • RenuTend
    • Semintra (2 procedures)
    • Senvelgo
    • Simparica Trio
    • Strangvac
    • Tulinovet

    The Committee adopted, by consensus, positive opinions for variations requiring assessment to align the product information with version 9/9.1 of the QRD template for:

    • Chanhold
    • Evicto
    • Meloxidolor
    • Novaquin
    • Osurnia
    • Strangvac
    • Zulvac 1+8 Bovis
    • Zulvac 1+8 Ovis
    • Zulvac SBV

    Maximum residue limits

    The Committee agreed to include polyethylenimine as a new entry in the list of substances considered as not falling within the scope of Regulation (EC) No. 470/2009 under the heading of ’Excipients’. This decision followed the Committee’s review of a request that had been submitted by an applicant, in accordance with the relevant CVMP guidance.

    Scientific advice

    The Committee adopted five scientific advice reports for two biological products, two immunological products and one pharmaceutical product for dogs (1 product), horses (1 product), cats (2 products) and Atlantic salmon (1 product).

    Limited market classifications and eligibility according to Article 23 of Regulation (EU) 2019/6

    Following three requests, the CVMP classified:

    • A product (ATCvet classification: Antineoplastic and immunomodulating agents) for dogs as intended for a limited market and eligible for authorisation under Article 23 of Regulation (EU) 2019/6.
    • A product (ATCvet classification: Immunologicals) for pigs as not intended for a limited market and not eligible for authorisation under Article 23 of Regulation (EU) 2019/6.
    • A product (ATCvet classification: Alimentary tract and metabolism) for horses as intended for a limited market and eligible for authorisation under Article 23 of Regulation (EU) 2019/6.

    Concept papers, guidelines

    Immunologicals

    The Committee adopted a revised guideline on the procedure to be followed when a batch of a vaccine finished product is suspected to be contaminated with bovine viral diarrhoea virus (EMA/CVMP/IWP/225007/2025). The revision consists of administrative changes to align the guideline with the definitions and terminology provided in Article 4 of Regulation (EU) 2019/6. The references to the applicable legislation and other scientific guidelines have also been updated. As no changes were made to the scientific content, no concept paper or public consultation was deemed necessary. The revision will come into effect on 1 April 2026.

    The Committee adopted a revised Guideline on duration of immunity achieved by veterinary vaccines (EMA/CVMP/IWP/224985/2025). The revision consists of administrative changes to align the guideline with the definitions and terminology provided in Article 4 of Regulation (EU) 2019/6. The references to the legislation applicable and other scientific guidelines have also been updated. As no changes were made to the scientific content, no concept paper or public consultation was deemed necessary. The revision will come into effect on 1 April 2026.

    Quality

    The Committee adopted a guideline on in-use stability testing of VMPs (EMA/CVMP/QWP/59158/2025). This guideline replaces and merges the ‘Note for guidance on in-use stability testing of veterinary medicinal products (excluding immunological veterinary medicinal products)’ (EMEA/CVMP/424/01 – FINAL) and the ‘Note for guidance on maximum shelf-life for sterile medicinal products after first opening or following reconstitution’ (EMEA/CVMP/198/99 – FINAL). Administrative changes have been made to align the guideline with Regulation (EU) 2019/6 and the current EMA template for Guidance. The references to the applicable legislation and other scientific guidelines have also been updated. As no changes were made to the scientific content, no concept paper or public consultation were deemed necessary. The guideline will come into effect immediately after publication.

    The Committee adopted a question and answer on histamine limits for gentamicin-containing parenteral VMPs for horses. The question and answer will be published within the Quality of medicines questions and answers: Part 1 on the Agency’s website.

    International harmonisation

    The Committee adopted:

    • VICH GL22(R) on Studies to evaluate the safety of residues of veterinary drugs in human food: reproduction testing (Revision 1) for implementation
    • VICH GL23(R1) on Studies to evaluate the safety of residues of veterinary drugs in human food: genotoxicity testing (Revision 2) for implementation
    • VICH GL62 on Target animal safety of veterinary monoclonal antibody products for release for 5 months of public consultation.

    More information about the above-mentioned medicines (including their full indications), guidelines, reflection papers, questions and answers and other documents, such as overviews on comments received during consultation, can be found below under “Related content”.

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  • Ruby Tandoh Serves Up a New Book, ‘All Consuming,’ Offering a Smart, Witty Take on Food Today

    Ruby Tandoh Serves Up a New Book, ‘All Consuming,’ Offering a Smart, Witty Take on Food Today

    That comment, though, of Tandoh’s—wrily, drily perceptive; a pithy take on the historical and contemporary intersection of taste, age, gender, and status—sets the tone for All Consuming. It covers everything from hype restaurants (and the equally hype-y lines which often accompany them) to Nara Smith, and Martha Stewart, and Erewhon (her view in brief: a place of esoteric ingredients in search of a meal you could actually make out of them) to the importance of the food writing in the early days of Ebony magazine. It stops along the way at the relentless proliferation of online recipes (and the reasons we will never, ever use 99.9% of them), the political and cultural histories of restaurant criticism, and why we are never more than five minutes away from the release of yet another new cookbook.

    All Consuming is most definitely not a cookbook, though Tandoh has already authored four of those since she was a finalist on the Great British Bake Off in 2013. What All Consuming is instead is a smart, insightful, and highly engaging treatise on why we eat and drink what we do. It’s also funny, very funny, like, laugh-out-loud funny. (Tandoh on the rise of exotically monikered desserts when she was growing up in her native Britain: “Carissima, Romantica, Sonata, and Cassata Denice—all Italianate ice cream gateaux with the kind of names a person would use to catfish on a sugar daddy site.”)

    Tandoh writes from a place of deep love—sometimes lacing that love with just enough eyebrow-raised scepticism, which is what makes All Consuming so…consuming. As with her take on the bubble tea phenomena, she clearly has a sharp grasp on a generational interest in what we eat and drink, and how those who are busy TikToking, YouTubing, and Instagramming it all might think about it differently—and are shaping the broader food culture around the world in the bargain. Once you’ve finished All Consuming, it’s a bit like waking up hungry—to know and understand more, that is.

    You might find yourself (as I did) wondering why exactly Korean fried chicken is the only fried chicken game in town these days, or what life was like before sriracha, or how food can become disassociated from its origins before you even know it. “We’re reaching the inflection point in British culture,” Tandoh says, “where in the UK more people will say pizza is American than Italian.” New Haven-style pizza, she says, is the thing in London right now. Things change so nanosecond-fast, her book makes you realize, that the ascent of things like avocado toast, frosted cupcakes, and Kewpie mayonnaise feels like it all happened around the time we were learning to make fire.

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  • Chip Wickham pairs peaceful sounds and propellant rhythms on new album

    Chip Wickham pairs peaceful sounds and propellant rhythms on new album

    Chip Wickham’s relaxing new album, which layers flutes and saxophones into serene soundscapes, is a peaceful respite in anxious times.

    Wickham calls The Eternal Now a “creative place where time has no purpose.” But it’s the time keeping of drummer Luke Flowers, a revered member of long running nu-jazz group Cinematic Orchestra, that keeps the dreamlike music interesting and brings energy to an otherwise sleepy collection.

    A native of Brighton, England, Wickham’s career included early efforts to bring his reeds to the breakbeats of producer and DJ Nightmares on Wax. More recently he’s focused on his love of jazz, from swinging hard bop to mellow spiritual jazz, as well as more modern beat-centered sounds.

    On the new record, the gently floating lead track “Drifting” matches relaxing sax lines from Wickham and bubbling bass and synthesizer support. Then Flowers’ beat enters, a hip-hop clave powering the song and getting your head bobbing.

    Rising English soul singer PEACH also brings her haunting delivery to the album’s only vocal feature, “Nara Black.” Another mid-tempo song packed with Flowers’ funky rhythms, “Nara Black” features PEACH’s own lyrics, inspired by the Japanese tattoo ink that gives the song its title.

    Meditative layers of flutes decorate the downtempo gem “Lost Souls,” as Wickham’s lovely repetitive phrases hint at the modal jazz of Miles Davis. The gentle mallets on drums and a spare but effective bass line from Simon “Sneaky” Houghton round out the track.

    As an album, The Eternal Now is a beautiful soundtrack for a lazy day at home with a hot cup of tea. While some may enjoy the album as a personal score to their chill out session, Wickham and his bandmates bring in plenty of depth and detail to reward headphone listening, as well.

    Wickham has earned praise this year for his collaborations with producers Somewhere Soul and Blue Mode. He’s also worked with English harpist Amanda Whiting and the modern library music obsessed producer/musicians at ATA Records.

    As the English modern jazz scene continues to produce wonderfully compelling young musicians, veteran Chip Wickham is enjoying some much-deserved attention. The Eternal Now is a mesmerizing way to start your fandom.


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  • Don’t miss the moon shine close to the Pleiades star cluster on Sept 12

    Don’t miss the moon shine close to the Pleiades star cluster on Sept 12

    Look east on the night of Sept. 12 to see the waning gibbous moon close to the magnificent Pleiades open cluster, with the distant planet Uranus lurking nearby in the constellation Taurus.

    The 62%-lit moon climbs above the eastern horizon a little over an hour before midnight for viewers in the U.S., with the Pleiades sitting less than 5 degrees to its upper right. To estimate that distance, hold out your hand: the width of your middle finger at arm’s length spans roughly 5 degrees of sky..

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  • Shaun White and Nina Dobrev call off their engagement, break up after 5 years

    Shaun White and Nina Dobrev call off their engagement, break up after 5 years

    Shaun White and Nina Dobrev have called off their engagement and brought an end to their five-year relationship, a person close to the couple told The Associated Press.

    The three-time Olympic champion snowboarder and the former star of “The Vampire Diaries” made a mutual decision to part, according to the person.

    The person spoke on condition of anonymity because of the sensitivity of the situation.

    People magazine first reported the breakup.

    White, 39, and Dobrev, 36, went public about their relationship in 2020. One of their first Instagram posts, which came toward the start of the COVID lockdown, showed Dobrev giving a “quarantine haircut” to the Olympic halfpipe rider known in his younger days as “The Flying Tomato” for his long shocks of red hair.

    They shared occasional posts about their travels over the next few years, and supported each other’s careers. Dobrev followed White on his frenetic road to qualifying for his fifth and final Olympics in 2022 and White was front and center in 2023 for the Los Angeles premier of Dobrev’s Netflix movie, “The Out-Laws.”

    After finishing fourth at the Beijing Olympics, White credited Dobrev for pushing him to make a to-do list for retirement “so I’m not sitting around twiddling my thumbs.”

    They announced their engagement in October 2024, posting a picture of White kneeling in front of Dobrev at a New York restaurant, the couple surrounded by white rose petals and candles. “She said YES,” White wrote in the post, adding an emoji of a diamond ring.

    People reported the couple was seen together in public as recently as Aug. 31, but Dobrev was spotted walking a red carpet at the Toronto International Film Festival last week without her engagement ring.

    White has spent the last two years starting up The Snow League, a pro halfpipe circuit he hopes will lead to more opportunities for people in his sport. Dobrev has reportedly been cast to star in a rom-com “It Happened One Summer” based on a best-selling book by Tessa Bailey.

    ___

    AP Olympics: https://apnews.com/hub/winter-olympics

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  • Suki Waterhouse Went Pantless—Again!—at the Michael Kors Show

    Suki Waterhouse Went Pantless—Again!—at the Michael Kors Show

    Her NYFW trip was a whirlwind, and it’s already back to work mode for Suki Waterhouse, who is preparing to embark on a new tour with Laufey this month. “Getting to tour with Laufey is going to be such a unique experience. I’m so excited to be around someone that who is so singular in her vision,” says Waterhouse. “There is no one else like her and I am honored to have the opportunity to tour with her and meet her fans.” Of course, Waterhouse comes with the tour wardrobe to match her hazy, romantic pop sound—think 70s-inspired glamour with lashings of that 2000s indie-rock aesthetic, all furry coats, ruffled blouses, and clompy platform boots.

    Naturally, she has some preparations to do before living life out on the road once again. “Touring feels like home these days, but that said, I do have a lot to do to make it feel like home, so there are quite a few things left on my to-do list before heading out,” she says. Her first stop? Orlando, Flordia, this coming Monday. “I just finished in Europe, so there are suitcases everywhere and my apartment is a complete mess,” the star says. (Relatable.) “It’s time to get organized!”

    See you soon Michael!

    Photo: Kat Slootsky

    Below, see exclusive photos and some fun little notes from Suki Waterhouse’s NYFW day with Michael Kors.

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  • Sazgar Announces Upcoming Upgrades for Facelift Haval H6 PHEV

    Sazgar Announces Upcoming Upgrades for Facelift Haval H6 PHEV

    Sazgar Engineering Works Limited has announced that Android Auto and Apple CarPlay will be made available in the facelifted Haval H6 PHEV through a software update starting October 15, 2025.

    In a statement, the company said Pakistan is the first market outside China to launch the facelifted H6 PHEV. Due to strong demand, the vehicle was introduced immediately, though the two connectivity features were initially unavailable.

    The company confirmed that the update will be rolled out in every H6 PHEV, including those already delivered to customers. It added that all other existing Haval models already have Android Auto and Apple CarPlay available.

    Sazgar thanked customers for their patience and continued trust, assuring them that the features will be activated as part of the upcoming update.


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  • The impact of CARF on the global cryptocurrency industry

    The impact of CARF on the global cryptocurrency industry

    CARF emerged as a way to close the transparency gap that allowed cryptocurrency transactions to occur outside traditional banking oversight systems, essentially creating a crypto version of existing financial reporting standards

    Key insights:

        • CARF is a global initiative designed to bring tax transparency to cryptocurrency CARF aims to prevent tax evasion by requiring crypto service providers to report customer and transaction data to tax authorities, who then share this information internationally.

        • CARF’s adoption is rapidly progressing With widespread international buy-in, platforms are now compelled to expand their KYC standards, necessitating significant overhauls in data collection, user on-boarding, and detailed transaction categorization.

        • CARF is pushing cryptocurrency towards a more transparent, regulated, and institution-friendly futureWhile CARF promises to reduce fraud and harmonize rules, it could also create a split market between the regulated and the hidden, sparking ongoing debates about privacy and enforcement.


    As cryptocurrencies exploded in popularity over the past few years, tax authorities around the world faced a growing problem. While they had successfully created systems to track traditional banking transactions through the Common Reporting Standard (CRS), crypto transactions were happening completely outside this framework. People could buy, sell, and trade digital assets through exchanges and wallet providers without their home countries’ tax authorities knowing anything about it.

    Recognizing this threat to global tax transparency, the G20 asked the Organisation for Economic Co-operation and Development (OECD) to develop a solution. The result was the Crypto-Asset Reporting Framework (CARF) — essentially a crypto version of the existing banking transparency rules.

    CARF works by requiring cryptocurrency service providers, such as exchanges and wallet providers, to collect information about their customers and report their transactions to local tax authorities. These authorities then share this information with the customers’ home countries, just like they do with traditional bank account data.

    The goal is simple: Prevent the crypto market from becoming a way for people to hide taxable income and transactions from their governments, preserving the progress made in global tax transparency over the past several years.

    The current status of crypto-regulation

    By 2025, a monumental shift had occurred in the landscape of global cryptocurrency regulation. More than 60 nations — encompassing all G7 members and most G20 economies — formally embraced CARF, marking a palpable acceleration toward a standardized international approach. Already, 52 of these jurisdictions were diligently preparing to exchange their initial batches of data by 2027, with an additional 15 poised to follow suit in 2028.

    While widespread adoption was evident, a handful of prominent crypto markets had yet to officially join the CARF agreement. Nevertheless, a clear wave of international pressure was mounting, aimed at bringing these remaining nations into compliance and thereby preventing them from inadvertently fostering illicit financial activities.

    Indeed, cornerstone of CARF across these diverse jurisdictions was its commitment to consistency. Core definitions and reporting requirements were meticulously crafted to be uniform, fostering a level playing field and simplifying implementation. Any variations observed between countries primarily pertained to practicalities, such as their specific implementation timelines, the penalties associated with non-compliance, and whether domestic, non-cross-border crypto transactions would also fall under reporting mandates.

    The advent of CARF fundamentally reshaped the operational paradigms for crypto platforms. The established Know Your Customer (KYC) principle for financial services regulation, traditionally focused on anti-money laundering, now expanded to encompass a new imperative: Know Your Customer’s Tax Status, with platforms mandated to report accordingly.

    This profound shift necessitated a significant overhaul for many crypto businesses, as they now faced the challenge of upgrading their systems for user on-boarding and data management. This included the crucial task of collecting self-certifications of tax residency from their users and implementing novel procedures to identify the controlling individuals of any entity customers. Moreover, platforms were now required to meticulously gather detailed transaction data, carefully categorizing each entry by type, differentiating between fiat-to-crypto, crypto-to-crypto, and various forms of transfers.

    What the future holds

    By 2030, CARF could mark crypto’s shift into a transparent, accountable asset class. Best case, it mainstreams crypto, reduces fraud and tax evasion, and harmonizes rules across countries while allowing for further innovation. Worst case, strict enforcement drives activity underground and deepens rifts with regulators. Most likely, we land in the middle: More transparency and fewer havens that ignore CARF or similar rules.

    Indeed, CARF is a major test of global crypto-governance. Its success depends on international cooperation, competent enforcement, and the industry’s ability to adapt to new transparency standards. The era of easily hiding wealth in crypto is ending, and a more accountable — and possibly more trusted — system is emerging.

    CARF likely will make crypto look more like traditional finance. Clearer tax rules and reporting could draw in large institutions and more everyday users. Compliant exchanges may operate more easily across borders under a single standard, and markets in CARF countries may become more professional, with fewer anonymous users and more strong oversight.

    Yet, some worry that this could cause the market to split, leaving, on one hand, a regulated, transparent side and on the other, a hidden side using privacy tools and decentralized systems. Governments will try to shrink the latter by expanding CARF and improving analytics, possibly using AI to match blockchain activity with reported data. This, of course, will spark debates about accuracy and privacy.

    Rules will keep evolving, especially for decentralized finance and self-custody. We may get clearer guidance on when decentralized platforms must report; and if more activity moves peer-to-peer, some countries could require individuals to declare holdings and income directly. CARF data might also be used — carefully and with safeguards — for financial crime enforcement, which would naturally raise civil liberties concerns.

    For most users, crypto may become just another taxable asset. You buy, sell, earn staking rewards, and receive tax forms or pre-filled reports. New services will emerge, such as crypto tax tools, compliance-linked insurance, and cross-border tax optimization. Privacy tech will advance too, including ways to prove compliance without revealing everything.

    Today, governments expect higher tax revenue and better compliance — and strong results with CARF will attract more countries. Eventually, tax authorities will use CARF data to verify returns, send notices, and audit mismatches. For compliant users, this should be routine; and for non-compliant users, risks and costs will rise.


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  • CM Gandapur moves PHC against passport ban

    CM Gandapur moves PHC against passport ban

    PESHAWAR (Dunya News) – Khyber Pakhtunkhwa Chief Minister Ali Amin Gandapur filed a petition in the Peshawar High Court against the blocking of his passport.

    The petition requests the court to order the removal of Gandapur’s name from the Exit Control List (ECL) and the restoration of his passport, citing that he holds the position of the province’s chief executive.

    More to read: Remarks about Imaan Mazari were taken out of context: IHC CJ Dogar

    According to his legal team, the petition was filed after consultation and includes a request for urgent hearing. The CM’s lawyers argue that preventing a sitting chief minister from international travel is unlawful and obstructs official duties.

    The court is expected to set a hearing date soon.

     


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  • United Airlines flight makes emergency landing in Japan, two people injured – Reuters

    1. United Airlines flight makes emergency landing in Japan, two people injured  Reuters
    2. United Airlines Flight makes terrifying emergency landing over mid-air fire fears  Daily Mail
    3. United Airlines Flight 32 Boeing 737 from Tokyo-Narita to Cebu diverted due to indication of potential fire in cargo hold  MarketScreener
    4. United Airlines passengers evacuate via emergency slides at Japan’s Kansai Airport after fire alert  Latest news from Azerbaijan
    5. A United Airlines passenger plane makes emergency landing in Osaka as cargo fire is suspected  The Indian Express

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