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  • Ellie Kildunne on Women’s Rugby World Cup motivation for England

    Ellie Kildunne on Women’s Rugby World Cup motivation for England

    The reigning world player of the year, Kildunne has been one of the figureheads of the tournament, featuring in organisers’ and sponsors’ promotions.

    She says it is surreal to see herself on billboards, in magazines and on social media posts.

    “Yeah, it feels strange because I’m just a girl from Yorkshire who’s playing rugby,” she says.

    “I’m nothing special. I just love what I do. I just think it’s important to be strong to your values and remember who you are and where you’ve come from because that’s a person that’s got you here.

    “It’s not all the showbiz and the lights and the cameras – it’s that young girl that picked up a rugby ball.”

    The 25-year-old, who straightened her distinctive curly hair on Monday as the result of losing a bet at training, says that while others may be looking ahead to the 27 September final, England’s focus is solely on the United States in their opening game.

    “We’ll be where our feet are – we don’t look too far ahead,” she said.

    “There’s no point in looking to the final or if and when we win, because if we don’t get now right, that will never be anything. It’s all ifs, buts and maybes.

    “But if we focus on now, we’ve got this week leading to the United States, we’ve finished a hard training session, how do focus on our culture and bonding tonight? How do we get closer as a team?

    “That’s going to be the thing that wins the World Cup. You can’t look too far ahead because you’ll trip over.”

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  • US Open mixed doubles: Why has the new format been so controversial?

    US Open mixed doubles: Why has the new format been so controversial?

    The thought of the top men’s and women’s singles players teaming up is one that has often intrigued tennis fans around the world.

    It’s part of the reason the mixed doubles event sometimes draws so much interest during the Olympics, with Taylor Fritz and Coco Gauff and Daniil Medvedev and Mirra Andreeva forming two star-studded pairings at Paris 2024.

    It is also one of the few opportunities men and women have to directly compete against each other in professional sports.

    Now, the US Open – the fourth and final grand slam of the season – is aiming to cash in on that intrigue with a revamped version of the mixed doubles.

    Rather than having the event run concurrently with the singles and doubles, as is traditionally the case at grand slams, a shortened edition will now take place on the Tuesday and Wednesday of the US Open’s ‘Fan Week’ that precedes the start of the main draw, which kicks off next week.

    Sixteen pairs will take part in a shortened format that is best of three sets, but each set is only the first to four games and there will be no advantage after deuce, with the winner of the next point winning the game. There will also be a 10-point tie break instead of a full third set.

    “It’s a radical change by the US Open,” Bob Bryan – one half of identical twin duo the Bryan Brothers, the most successful men’s doubles pairing in tennis history – told CNN Sports’ Don Riddell.

    “It’ll be sold out in Arthur Ashe Stadium, all the stars, the single stars are playing it. The downside is that the doubles players won’t get a shot to play it or to defend their title or whatever, but the prize money is a big increase.”

    Prize money for the winning pair this year is $1 million, a mammoth increase of $800,000 – or five times more – from 2024.

    And the US Open’s attempt to lure big names to take part has clearly worked.

    Five-time grand slam singles champion Carlos Alcaraz teaming up with Emma Raducanu and current Wimbledon champion Iga Świątek joining forces with Casper Ruud, what’s not to like?

    Well, quite a lot if you ask some doubles specialists.

    Kristina Mladenovic, a former world No. 1 in doubles and nine-time grand slam winner across doubles and mixed doubles, said it’s “embarrassing” hearing the players saying they are “going to have fun” at the event as they prepare for the main singles draw.

    “A grand slam is neither preparation nor fun,” she told Eurosport. “It’s years of sacrifice. When you’re young, you dream of winning one, even in doubles.

    “In terms of business strategy, it’s a brilliant idea … but from a sporting point of view, it’s problematic because it touches on the essence of tennis. A grand slam is a competition steeped in history, in singles and doubles.

    “There’s no problem putting on such an event, but above all, don’t call it a grand slam.”

    Kristina Mladenovic (front) is one of a number of doubles specialists to criticize the event.

    At the time of the announcement, defending US Open mixed doubles champions Sara Errani and Andrea Vavassori called the format change a “profound injustice,” though they have since been given a wild card to defend their 2024 title.

    Jan Zielinski, mixed doubles champion at the Australian Open and Wimbledon in 2024, said there had been “no communication with players” from the organizers about the change.

    Organizers have already confirmed that the event, described as a “pseudo-exhibition” by Errani and Vavassori, will count as an official grand slam.

    So not only have the doubles specialists been denied the opportunity to compete for potentially career-changing prize money, they have also been denied the chance to challenge for another grand slam.

    CNN Sports has reached out to the United States Tennis Association (USTA) for comment.

    Mike Bryan, Bob’s twin, says he understands players’ frustrations.

    “I mean, if we were on tour and we were left out of the possibility of winning a grand slam in mixed doubles, we’d probably be upset,” he told CNN Sports. “Now that we’re retired, we see it from a greater perspective of the US Open is a business.

    “But you don’t want it to cheapen a grand slam title. We’ll see. Maybe, maybe it won’t. Maybe, it’ll make it even bigger.”

    Carlos Alcaraz has signed up to play with British No. 1 Emma Raducanu.

    But being great singles players doesn’t automatically mean two stars will make a good doubles pairing. Court positioning, tactics and timing are vastly different between the two formats, with doubles specialists boasting more skills at the net than many top singles players.

    Currently, Andreeva and Jasmine Paolini the only two players across the men’s and women’s tours to be ranked inside the top 15 in both singles and doubles, though Coco Gauff has also previously been ranked inside the world’s top three in the two formats (No. 2 in singles and No. 1 in doubles).

    It is common for the doubles and mixed events to draw smaller crowds during grand slams than the singles and Mike Bryan says it was perhaps in danger of becoming an “afterthought” at the US Open.

    “As players that play doubles, we’re just hoping that kind of trickles down to the popularity of the doubles game itself, which I think it will,” Bob added. “So we’re excited to see how it goes.

    “Let’s see if the other grand slams take a look at it and are interested in making the same change, but it’s a kind of a groundbreaking decision and it could revolutionize mixed doubles for years to come.”


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  • Aggresomes protect mRNA under stress in Escherichia coli

    Aggresomes protect mRNA under stress in Escherichia coli

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  • Preview of Chinese game developers at Gamescom 2025 · TechNode

    Preview of Chinese game developers at Gamescom 2025 · TechNode

    As one of the world’s largest gaming events, Gamescom has become a key bridge between Europe and the global industry. This year, several Chinese games will debut new trailers or offer hands-on demos to overseas players for the very first time, signaling both confidence in their products and a deeper commitment to engaging with international audiences.

    Amid shifting industry dynamics and changing player expectations, Chinese developers face a challenge that goes beyond technology: balancing local cultural richness with global trends. From August 20 to 24 at Gamescom 2025 in Cologne’s Koelnmesse, Chinese developers will present a varied lineup, from RPGs (role-playing games) and wuxia (martial arts) action to sci-fi adventures and mobile hits.

    Game Science: Black Myth: Wukong returns with anniversary showcase and possible new reveals
    Black Myth: Wukong, the highly anticipated action RPG from Game Science, is confirmed to participate in Gamescom 2025. This appearance aligns with the one-year anniversary of the game’s initial release, making it a strategic moment for the studio to engage both domestic and international audiences.

    Fans currently expect significant reveals, although the studio has not confirmed exact details. Speculation focuses on the launch trailer for the Xbox version, along with a potential DLC reveal of Black Myth:Wukong. Media and fans are also hoping for hints about new entries in the Black Myth universe.

    Beijing S-Game: Phantom Blade Zero offers first overseas demo play
    The Chinese single-player wuxia game Shadow Blade: Zero will offer one-hour demo play at Gamescom 2025. This marks the first time the game will be available for overseas players to try. The booth will cover around 500 square meters and feature 60 demo stations for attendees.

    During Gamescom, Shadow Blade: Zero will also appear on the Future Games Show stage hosted by Xbox on August 21, presenting the game to audiences through both online streaming and live demonstrations.

    miHoYo: Genshin Impact, Honkai: Star Rail, and Zenless Zone Zero take center stage with new content and Aston Martin collaboration
    The company has confirmed its attendance and will showcase its major titles: Genshin Impact, Honkai: Star Rail, and Zenless Zone Zero. At the Genshin Impact booth, visitors can explore the game’s upcoming in-game region, Nod-Krai, while Honkai: Star Rail will showcase the newly introduced Amphoreus location. Zenless Zone Zero will display its freshly revealed in-game faction, Spook Shack. Each booth will offer unique offline activities and exclusive merchandise for fans.

    miHoYo’s action game Zenless Zone Zero announced a major collaboration with British luxury sports car brand Aston Martin. The two companies will set up a real-life Aston Martin exhibition area at Gamescom. A collaboration PV (Preview Video) has been released, showcasing a futuristic sports car design that blends the game’s mechanical aesthetics with cyberpunk city style.

    Tencent Games: diverse lineup covering shooters, RPGs, sandbox worlds, and global mobile debuts
    Tencent Games will showcase a diverse lineup, including the anime-style shooter Fate Trigger with a new trailer at Opening Night Live, the first offline PC demo of Honor of Kings: World, the cross-platform sandbox Interstellar Utopia, a ghost-themed mobile update co-developed with KRAFTON, and Rust Mobile’s global hands-on debut.

    The collaborative action Roguelike shooter that Tencent Games will unveil at Gamescom 2025 has not yet been named and will feature an immersive demo for players worldwide.

    The global rise of Chinese game developers
    Gamescom 2025 is set to be the largest edition in the event’s history, bringing together more than 1,500 exhibitors from 72 countries and regions across a record exhibition space of 233,000 square meters.

    In recent years, Chinese developers are arriving with strong momentum: Black Myth: Wukong has sold an estimated 21.73 million units worldwide, including 16.88 million in China and 4.55 million overseas, while miHoYo continues to dominate the global mobile market with its flagship titles, generating billions of dollars annually in revenue from Genshin Impact, Honkai: Star Rail, and Zenless Zone Zero. Together, Chinese studios are increasingly shaping the global gaming landscape.

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  • Xbox Cloud Gaming Could Soon Be Cheaper, Hints Microsoft Exec – PCMag

    1. Xbox Cloud Gaming Could Soon Be Cheaper, Hints Microsoft Exec  PCMag
    2. Microsoft hints at “more affordable” Xbox Cloud Gaming plan  The Verge
    3. Xbox’s hardware legend reflects on the Series X|S and what’s coming next  Windows Central
    4. Next-gen Xbox consoles to feature AI neural rendering and cross-platform gaming  Mint
    5. Xbox Cloud Gaming: Why a cheaper tier could change a lot  digit.in

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  • Little Mix’s Perrie Edwards discusses trauma of losing baby at 24 weeks

    Little Mix’s Perrie Edwards discusses trauma of losing baby at 24 weeks

    Mark Savage

    Music correspondent

    Getty Images Perrie EdwardsGetty Images

    Perrie Edwards said she had suffered two miscarriages

    Little Mix star Perrie Edwards has spoken for the first time about the trauma of losing a baby at 24 weeks.

    The singer, 32, said she became pregnant less than a year after the birth of her first son, Axel, in August 2021.

    But after the pregnancy passed the five-month mark, a scan revealed the baby’s heart had stopped beating, which was the “worst day of my life”.

    “I remember sobbing,” she told Paul C Brunson’s We Need To Talk podcast, fighting through tears. “I couldn’t see straight. I was just distraught. We basically lost the baby at, like, 24 weeks.”

    Edwards described the scan as “an out of body experience” and said she was unable to process the doctor’s words.

    The news only sunk in when her fiancé, former Liverpool footballer Alex Oxlade-Chamberlain, “put his hand on my leg and went, ‘Oh no’,” she said.

    Although the experience was “traumatising”, Edwards said she had taken comfort from fellow musician Myleene Klass, who was recently awarded an MBE for her work to increase miscarriage awareness.

    Klass once said that when you go through a miscarriage, “the baby stays with you”.

    “I was like, ‘Oh wow, that’s so magical’,” said Edwards. “If I’m blessed enough to have another baby in the future, it makes me feel that they’re still a part of it in some way.”

    Getty Images Perrie Edwards and Alex Oxlade-Chamberlain pose with their baby son on a football pitch in 2022Getty Images

    Edwards has a son, Axel, with her footballer partner Alex Oxlade-Chamberlain

    Edwards also revealed that Axel, who turns four this week, was a “rainbow baby” – a term used to describe a baby born to a mother who has previously lost a child due to miscarriage, stillbirth or neonatal death.

    She explained: “I had a miscarriage very early on with my first ever pregnancy.

    “I remember finding out I was pregnant [but] I started bleeding not long after, and I went to hospital and I had the scan and they were like, ‘There’s no baby.’

    “I was like, ‘Oh, I’ve made this up. Maybe I got a false positive or something.’”

    She was left confused about what had happened until a later appointment with her gynaecologist, who told her she had suffered a miscarriage.

    Edwards said the loss hadn’t affected her as badly as her second miscarriage.

    “I think because it was so early, I was like, ‘Oh, that’s sad.’

    “But I think when you’re fully carrying and you’re 24 weeks and you’ve planned out their room and all these things, it’s really hard.

    “I’ve never spoke about it before because obviously I ended up a wreck and nobody knows other than immediate friends and family.”

    The singer’s experiences are sadly not unique.

    In the UK, one in five pregnancies end in miscarriage and there are around 2,000 terminations following a pre-natal screening each year.

    In 2017, a report into aftercare for women who had lost a baby during pregnancy found that, although care was good and improving in many hospitals, it was inconsistent across England, leaving some women feeling misinformed and distressed at a vulnerable time.

    Last year the Department of Health and Social Care announced a package of new measures to “boost the health and wellbeing of women and girls”, including a pilot scheme that will see medical intervention for women after every miscarriage.

    Perrie Edwards

    Perrie Edwards has sold more than 75 million records as part of Little Mix

    Elsewhere in the podcast, Edwards reflected on her romance with One Direction star Zayn Malik, which began while she was a contestant on The X Factor in 2011.

    The couple were engaged for a time, but the relationship fell apart in 2015 amid a flurry of press speculation, including allegations of Malik’s infidelity.

    “Definitely at the time, I thought everything we experienced in our relationship was normal. Because it was my first relationship, first love,” she said.

    “I was like, ‘Oh, this is how it’s supposed to feel. It’s supposed to feel a little bit toxic. In some ways, this is probably normal, right?’

    “And then, when I became single, I was almost thinking, ‘I never, ever want to go through that again’. I didn’t even want to meet anybody.

    “I was like, ‘That’s me done’. I don’t think I could bear that pain. But now, I’m thinking, ‘Oh, that probably wasn’t good’.”

    Edwards joined Little Mix when the band were formed during the eighth series of The X Factor, and the group went on to sell 75 million records worldwide.

    Over the next 11 years, they became the third-biggest girl band of all time (behind the Spice Girls and the Supremes) and the first to spend more than 100 weeks inside the UK top 10.

    In 2021, they became the first girl band to win best British group at the Brit Awards – but they went on hiatus shortly afterwards to “recharge” and work on solo projects.

    All four members – Edwards, Leigh-Anne Pinnock, Jade Thirlwall and Jesy Nelson – have released music since then, to varying degrees of success.

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  • Is adding sea salt to drinking water really healthy? Know its benefits and who should avoid |

    Is adding sea salt to drinking water really healthy? Know its benefits and who should avoid |

    In recent months, a growing wellness trend has taken over social media platforms like TikTok, where influencers and health enthusiasts recommend adding sea salt, especially Celtic sea salt, to drinking water. Advocates claim this simple practice can improve hydration, support digestion, boost skin health, and restore electrolyte balance. Unlike processed table salt, Celtic sea salt is rich in trace minerals such as magnesium, potassium, and calcium. According to a study published in the Journal of the International Society of Sports Nutrition, adding a small amount of salt to drinking water can help maintain electrolyte balance and improve hydration, especially during prolonged exercise or heat exposure. It is believed that these minerals help the body absorb water more efficiently.

    Understanding celtic sea salt and its benefits to improve overall health

    Celtic sea salt is an unrefined salt harvested from the coastal regions of France. Unlike table salt, which undergoes extensive processing, Celtic salt retains its natural mineral content. The extraction process involves allowing seawater to evaporate in clay ponds, followed by the use of wooden rakes to collect the salt, ensuring minimal processing and preserving its trace minerals.These trace minerals, which include magnesium, potassium, calcium, and iodine, are often cited as the primary health benefits of Celtic sea salt. However, it’s important to note that while these minerals are present, they are in relatively small quantities. For instance, Celtic salt contains about 85 to 90% sodium chloride, which is comparable to other sea salts like Cornish or Himalayan salt, but with a slightly lower sodium content

    Potential benefits of sea salt in water

    While the scientific backing is limited, proponents of the practice highlight several potential benefits:1. Enhanced hydrationThe presence of sodium in sea salt can help the body retain water, supporting cellular hydration. Sodium works with potassium to regulate fluid balance, particularly during intense physical activity or exposure to heat. This can be particularly useful for athletes or individuals who struggle with staying hydrated despite drinking plenty of water.2. Improved skin appearanceTrace minerals such as magnesium, calcium, and potassium found in unrefined sea salts are believed to contribute to healthier-looking skin. These minerals play roles in skin cell regeneration, pH balance, and reducing inflammation, potentially resulting in a clearer, more radiant complexion over time.3. Digestive supportSalt is essential for producing hydrochloric acid (HCl) in the stomach. Adequate stomach acid is crucial for proper digestion, especially for breaking down proteins and absorbing nutrients like vitamin B12, iron, and zinc. Adding a small amount of sea salt to water may help stimulate digestive secretions and support better nutrient absorption.4. Improved adrenal functionChronic stress can place a heavy burden on the adrenal glands, which regulate hormone production, including those involved in energy and hydration. Some practitioners of functional medicine suggest that unrefined sea salt may support adrenal health by providing trace minerals that help modulate stress response and maintain energy levels.5. Reduced cravings for sugary or processed foodsMineral deficiencies can sometimes trigger cravings, especially for salty or sweet snacks. By supporting the body with trace minerals found in sea salt, some individuals report reduced cravings and better appetite regulation. This may indirectly support healthier eating habits.6. Mild detoxificationSome holistic practitioners believe that the trace minerals in sea salt help facilitate natural detoxification processes in the body by supporting lymphatic flow, kidney function, and cellular waste removal. While this is largely anecdotal, many include sea salt as part of cleansing protocols.7. May help with muscle crampsSodium and magnesium are crucial for muscle function. A deficiency in either can lead to cramps or spasms, particularly during or after exercise. Including a pinch of mineral-rich sea salt in water might help reduce the risk of muscle cramps by supporting optimal electrolyte levels.8. Brain function and nerve communicationSodium and other electrolytes play a vital role in nerve transmission and brain function. Maintaining the right balance helps with concentration, mood regulation, and cognitive clarity. Some proponents claim that mineralised water can help prevent the sluggishness or mental fatigue associated with dehydration.9. Improved sleep qualityMagnesium, found in trace amounts in sea salt, is linked to better sleep and relaxation. While the amount in one glass of saltwater is small, consistent intake of trace minerals throughout the day, especially in the evening, may support more restful sleep patterns.It’s crucial to approach these potential benefits with caution, as the evidence supporting them is largely anecdotal and not robustly supported by scientific research.

    Who should avoid adding sea salt to water

    While a pinch of sea salt in water is generally considered safe for most healthy individuals, certain groups should exercise caution:

    • Individuals with high blood pressure: Excessive sodium intake can exacerbate hypertension.

    • Those with kidney disease: Impaired kidney function can make it difficult to regulate sodium levels.

    • People on sodium-restricted diets: Those advised to limit sodium intake should avoid adding salt to their water without medical supervision.

    The recommended daily intake of sodium chloride for adults is no more than 6g, which equates to about one level teaspoon. It’s important to consider all sources of sodium in your diet to avoid exceeding this limit.Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional before making any changes to your health routine or treatment.Also read | Arjun Chaal benefits for heart health and control blood pressure naturally


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  • Bernstein analysts see crypto bull market running through 2027 – The Block

    1. Bernstein analysts see crypto bull market running through 2027  The Block
    2. Bitcoin Could Keep Surging to New Highs Into 2026, Says Bernstein  Decrypt
    3. Bitwise CIO outlines four catalysts the crypto market hasn’t priced in, from government bitcoin buys to ‘ICOs 2.0’  The Block
    4. Crypto’s bull run is just beginning. Here are 3 stocks to play. [Video]  AOL.com
    5. Robinhood price target raised to $160 from $105 at Bernstein  TipRanks

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  • PSO Posts Profit After Tax of Rs. 20.9 Billion in FY25

    PSO Posts Profit After Tax of Rs. 20.9 Billion in FY25

    Pakistan State Oil (PSO), the nation’s trusted energy partner, successfully navigated complex market dynamics to achieve steady financial results, showcasing its strategic agility and adaptability. The Board of Management convened on August 19, 2025 in Karachi to review the group’s performance for the fiscal year ended June 30, 2025.

    Despite navigating policy uncertainty, trade tensions, and financial market volatility, the company delivered robust financial results, reporting a notable profit after tax of PKR 20.9 billion. The Board of Management announced a dividend of PKR 10 per share, representing a payout ratio of 22.5% for the financial year 2024-25.

    On a consolidated basis, including Pakistan Refinery Limited (PRL), the group achieved a profit after tax of PKR 16.4 billion, yielding an Earnings Per Share (EPS) of PKR 35.03.

    PSO continued to lead the market, securing a 44% share of the liquid fuel market in FY25. The company continued its dominance across key petroleum segments, capturing a 45.7% share in the white oil segment and solidifying its position in a highly competitive landscape.

    PSO with a 40.8% market share, sold 3.2 million metric tons in the motor gasoline segment. The company also sustained its leadership in diesel with a 46% market share and sales of 3.1 million metric tons. Even in the black oil segment, where demand declined due to the country’s shift towards alternative energy sources, PSO supplied 131,000 metric tons, demonstrating its adaptability and market resilience.

    PSO cemented its unparalleled leadership in the jet fuel market, commanding a remarkable 99% market share while delivering seamless refueling operations at 15 strategically located airports nationwide. In a bold and innovative stride, the company launched a state-of-the-art mobile jet fuel refueling facility at the New Gwadar International Airport (NGIAP), driving Pakistan’s infrastructure development and aviation ambitions forward.

    PSO’s strategic initiatives drove remarkable growth in the lubricants sector, boosting market share to 29% and sales volumes to 41,000 metric tons. Meanwhile, the company’s LPG business achieved a major milestone in FY25, with volumes surging to 60,000 metric tons, representing a substantial 22.4% year-on-year (YoY) increase.

    In a landmark collaboration, PSO and the State Oil Company of the Azerbaijan Republic (SOCAR) are establishing a joint trading company in Singapore, strategically positioned to strengthen Pakistan’s energy security and leverage global market opportunities. This innovative venture is designed to optimize energy procurement, drive efficiency, and cultivate enduring trade partnerships.

    PSO’s 427-kilometer White Oil Pipeline project, a strategic partnership with Frontier Works Organization (FWO), has achieved a significant benchmark with the completion and review of the Front-End Engineering Design (FEED) draft. The pipeline, stretching from Machike to Tarujabba, aims to enhance the efficiency and safety of oil transportation, reduce traffic congestion, and minimize environmental pollution. Once operational, it will play a vital role in Pakistan’s energy security and supply chain infrastructure.

    PSO continued to strengthen its storage and logistics infrastructure, achieving an impressive operational availability rate of over 90% throughout the year. Key highlights include the rehabilitation of 7 tanks, increasing total storage capacity to 1.24 million tons. This enhancement will enable PSO to better manage supply chains, reduce bottlenecks, and ensure a steady fuel supply to meet customer demands.

    PSO completed fuel handling facilities at 8 strategic railway sites, significantly enhancing intermodal efficiency and streamlining nationwide fuel distribution. This upgrade enables seamless logistics operations, reducing transit times and costs while improving supply chain reliability.

    In FY25, PSO aggressively expanded its retail footprint, adding 107 new outlets to reach a total of 3,649 across the country. With over 310 convenience stores, PSO is reimagining fuel stations as one-stop destinations for everyday essentials, elevating the customer experience and setting new standards in retail sector.

    PSO introduced its innovative VIBE concept stores in Karachi, Lahore, and Islamabad, redefining the convenience shopping experience. These stores set a new benchmark in retail innovation, offering customers a unique blend of fuel services and everyday essentials in a modern, customer-centric environment.

    Leading Pakistan’s clean mobility drive, PSO, in partnership with BYD Pakistan and HUBCO Green, unveiled the country’s first New Energy Vehicle fast-charging station on the M2 motorway. With plans for 128 DC fast chargers and 50 stations operational by December 2025, the company is setting the standard for EV charging infrastructure.

    The company has launched the first phase of Asaan Safar, a travel enhancement program designed to elevate the overall travel experience across Pakistan. Through the Fuelink app, travelers can effortlessly plan their trips, while upgraded stations now boast executive restrooms, curated essentials, and fully stocked stores, ensuring a comfortable and convenient journey.

    LPG Blue made its mark in Gilgit-Baltistan with the launch of Pakistan’s first e-commerce platform for pre-ordering LPG cylinders with last-mile delivery. This innovative platform complements PSO’s doorstep services, offering customers a seamless experience.

    CERISMA (Pvt.) Limited, a PSO subsidiary, has achieved a key milestone in its Electronic Money Institution (EMI) journey, successfully completing the pre-pilot inspection. With final regulatory approval pending, CERISMA is poised to launch pilot operations, marking a major step forward in Pakistan’s fintech landscape.

    PSO Renewable Energy (Pvt.) Limited is spearheading Pakistan’s transition to clean energy, driving the development and deployment of renewable energy projects in line with national low-carbon goals. Focused on solar energy, the company is committed to boosting profitability, creating new revenue streams and contributing to Pakistan’s renewable energy growth.

    Pakistan Refinery Limited’s (PRL) Refinery Expansion and Upgrade Project, supported by the Government’s Brownfield Refining Policy, is advancing steadily. The project is currently evaluating EPCF bids to ensure timely and efficient implementation, aiming to enhance refining capacity and meet growing energy demands.

    PSO’s digital transformation journey gained momentum with noteworthy advancements, including the automation of 2 terminals, installation of 498 dispensing controllers across 137 outlets, and deployment of 20 smart radar gauges. Additionally, core processes were streamlined, enhancing operational efficiency and setting a new standard for digital excellence in the industry.

    PSO continued its philanthropic efforts, investing PKR 500 million in FY25 to support critical initiatives in healthcare, education, disaster relief, community development, and environmental conservation. Through strategic partnerships with NGOs, the company reinforced its commitment to giving back to society and driving positive change.

    PSO demonstrated strong financial stewardship, improving receivables and liabilities management, leading to a 20% reduction in power sector circular debt and a decrease in SNGPL exposure by PKR 24.7 billion.

    PSO management extends its gratitude to the Board of Management, Government of Pakistan, Ministry of Energy (Petroleum Division), shareholders, employees, and all stakeholders for their continued trust and support.


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  • Acute onset Capgras syndrome after upper respiratory tract infection: a case report on the possible role of inflammation and drug exposure | BMC Psychiatry

    Acute onset Capgras syndrome after upper respiratory tract infection: a case report on the possible role of inflammation and drug exposure | BMC Psychiatry

    The patient was a 42-year-old woman, high school graduate, married, and mother of two children. She presented to the psychiatric outpatient clinic on January 19, 2024, complaining of insomnia, thoughts that her husband was cheating on her, and irritability. The patient had no prior history of psychiatric hospitalization or psychiatric illness and reported that these symptoms began approximately ten days after experiencing a severe upper respiratory tract infection.

    The patient presented to the emergency department approximately ten days ago with complaints of fever, shortness of breath, and fainting; laboratory and imaging tests resulted in a diagnosis of upper respiratory tract infection. Blood tests conducted at the time of admission revealed only a transient elevation in C-reactive protein (CRP) levels (22.85 mg/L), with no significant abnormalities in other systemic inflammation markers such as white blood cell count, ferritin, procalcitonin, or sedimentation rate. Clinical evaluation revealed normal oxygen saturation, a temperature of 38.1°C, and stable vital signs. No findings consistent with systemic inflammatory response syndrome (SIRS) criteria, such as hypotension, tachycardia, altered consciousness, or organ dysfunction, were observed. Therefore, it was concluded that the infection did not progress to systemic inflammation and remained limited to an upper respiratory tract infection. The patient was started on 200 mg cefuroxime and ibuprofen treatment. The patient returned to the emergency department due to worsening symptoms, and treatment was changed to 1000 mg amoxicillin-clavulanic acid, 200 mg ibuprofen, 30 mg pseudoephedrine hydrochloride, and 4 mg chlorpheniramine maleate.

    After this, the patient believed that her husband had been replaced by someone else, stopped talking to him, and did not answer his phone calls. The patient avoided meeting with family members, did not make eye contact with her husband, and showed a marked withdrawal from social interactions. Her husband stated that the patient had undergone a major change in the last ten days, did not respond to him, and frequently said, “What did you do to my husband?”

    Therefore, the patient was referred to the neurology department;

    Neurological Examination: conscious, cooperative, and fully oriented.

    Cranial nerve examination: Normal; no facial paralysis or visual field defects were detected. Muscle strength and tone were normal, and no motor weakness was observed. Deep tendon reflexes were symmetrical and normoactive. The Babinski reflex was bilateral negative. Light touch, pain, vibration, and position sense were normal. Finger-nose and heel-knee tests were normal, rapid, and coordinated; no dysmetria was observed. Fundus examination was normal; no papilledema was detected. No nuchal rigidity or other signs of meningeal irritation were observed.

    Brain MRI including T1, T2, FLAIR, and diffusion sequences showed no acute or chronic pathology. No signal changes suggestive of demyelination, mass lesion, or limbic encephalitis were observed. The basal ganglia, thalamus, brainstem, cerebellum, and cortical structures were normal. No restriction was detected on diffusion imaging, ruling out acute ischemic events or infectious encephalopathy. Lumbar puncture was not performed due to the absence of meningeal irritation findings, neurological focal findings, consciousness fluctuations, or cognitive fluctuations, and normal MRI and EEG results. Although rare possibilities such as autoimmune encephalitis have not been theoretically ruled out, the current clinical picture does not warrant invasive evaluation in this direction.

    During the neurological evaluation, a decrease in C-reactive protein (CRP) levels (CRP: 0.96 mg/L) was observed compared to the initial values obtained during the first emergency department visit (CRP: 22.85 mg/L), indicating a reduction in the inflammatory process. The patient did not undergo COVID-19 testing during emergency department visits or subsequent neurological evaluations, and no respiratory imaging findings suggestive of COVID-19 were recorded. However, the patient continued to believe that her husband had been transferred to another location. The following timeline summarizes the patient’s clinical findings and course (Fig. 1).

    Fig. 1

    Clinical timeline of the patient

    Psychiatric evaluation

    The patient’s general level of alertness was normal. Orientation and cooperation were intact. Attention span, short-term memory, and abstract thinking were adequate. Although a structured cognitive assessment scale (e.g., MoCA or MMSE) was not administered, the cognitive processes observed during the interview were within the expected limits for her age and educational level. She exhibited an anxious mood and affect, and her appearance and self-care were consistent with her age and sociocultural level. The patient had persistent and reality-detached beliefs in the content of her thoughts, particularly regarding the replacement of her husband and daughter with fake people. There was no insight into the delusions. Psychomotor activity was normal, and no catatonic features such as mutism, negativism, or stereotypy were observed. Therefore, there was no need to administer the Bush–Francis Catatonic Rating Scale. Following the initial psychiatric evaluation, the patient underwent electroencephalography (EEG) by the psychiatric team. EEG showed normal background activity with no generalized slowing or epileptiform activity. Additionally, the patient’s previously obtained brain magnetic resonance imaging (MRI) scans were re-evaluated by a radiologist to rule out any potential organic pathologies that could cause psychotic symptoms. This second evaluation, which specifically focused on limbic encephalitis, demyelinating lesions, or other structural abnormalities, also did not reveal any pathology.

    The patient, who had no history of psychiatric illness, reported that he was cheerful, active, and sociable prior to the onset of the illness and had no history of alcohol or substance abuse. Additionally, the patient had no known medical conditions or history of trauma/accidents, although he had undergone two cesarean sections in the past.

    The patient exhibited delusional misidentification consistent with Capgras syndrome, and antipsychotic treatment with 3 mg/day of paliperidone was initiated. According to DSM-5 criteria, the clinical presentation was consistent with a psychotic disorder characterized by sudden-onset delusional misidentification symptoms in a patient without a prior psychiatric history. Approximately one month after treatment initiation, the patient presented for a psychiatric follow-up examination. In this second psychiatric evaluation, clinical observations and information obtained from the family indicated no improvement in the patient’s symptoms. The patient stated, “An unknown man has taken my husband’s place, and I am afraid of him” and “He is deceiving everyone, and everyone believes him.” A relative noted that these symptoms began after flu-like symptoms and that there had been no previous episodes of this kind.

    Treatment was subsequently increased to 6 mg of paliperidone. According to family observations and clinical interviews, a slight decrease in the intensity of delusional beliefs was noted. Due to loss of follow-up, no post-treatment diagnostic tests or psychiatric evaluations were conducted. No adverse effects were reported during the short follow-up period; however, the short observation period limits the assessment of the drug’s tolerability.

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