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  • Strike by 10,000 Air Canada flight attendants declared illegal

    Strike by 10,000 Air Canada flight attendants declared illegal

    TORONTO — The Canada Industrial Relations Board declared a strike by 10,000 Air Canada flight attendants illegal Monday and ordered them back on the job after they ignored an earlier order to return to work and submit to arbitration.

    The strike at Canada’s largest airline entered its third day on Monday and is affecting about 130,000 travelers per day during the peak summer travel season, and the two sides remain far apart on pay and other issues. Air Canada suspended plans to restart operations Sunday after the union defied an earlier return-to-work order.

    “The members of the union’s bargaining unit are directed to resume the performance of their duties immediately and to refrain from engaging in unlawful strike activities,” the Canada Industrial Relations Board board, or CIRB, said in a written decision.

    The board, an independent administrative tribunal that interprets and applies Canada’s labor laws, said the union needs to provide written notice to all of its members by noon Monday that they must resume their duties.

    It was not immediately clear what recourse the board or the government has if the union continues to refuse.

    “We are in a situation where literally hundreds of thousands of Canadians and visitors to our country are being disrupted by this action,” Prime Minister Mark Carney said. “I urge both parties to resolve this as quickly as possible.”

    Carney said his jobs minister would have more to say later. Carney said it was disappointing that talks have not led to a deal, and added that it is important that flight attendants are compensated fairly at all times.

    The labor board previously ordered airline staff back to work by 2 p.m. Sunday and for the union to enter arbitration, after the government intervened. Air Canada then said it planned to resume flights Sunday evening. But when the workers refused, the airline said it would resume flights Monday evening instead. However, there was no sign that the Canadian Union of Public Employees, or CUPE, would relent.

    Air Canada operates around 700 flights per day.

    CUPE national President Mark Hancock on Sunday had ripped up a copy of the initial back-to-work order outside Toronto’s Pearson International Airport, and said members wouldn’t go back to work this week, to the cheers of picketing flight attendants.

    Flight attendants walked off the job around 1 a.m. EDT on Saturday, after turning down the airline’s request to enter into government-directed arbitration, which allows a third-party mediator to decide the terms of a new contract.

    Air Canada and CUPE have been in contract talks for about eight months, but remain far apart on the issue of pay and the unpaid work that flight attendants do when planes aren’t in the air.

    The airline’s latest offer included a 38% increase in total compensation, including benefits and pensions, over four years, that it said “would have made our flight attendants the best compensated in Canada.”

    But the union pushed back, saying the proposed 8% raise in the first year didn’t go far enough because of inflation.

    Passengers whose flights are impacted will be eligible to request a full refund on the airline’s website or mobile app, according to Air Canada.

    Last year, the government forced the country’s two major railroads into arbitration with their labor union during a work stoppage. The union for the rail workers is suing, arguing the government is removing a union’s leverage in negotiations.

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  • Gulf in line for potential benefits from Trump’s Nvidia-China deal | News

    Gulf in line for potential benefits from Trump’s Nvidia-China deal | News

     

     

    Mayer Brown is a global legal services provider comprising associated legal practices that are separate entities, including Mayer Brown LLP (Illinois, USA), Mayer Brown International LLP (England & Wales), Mayer Brown Hong Kong LLP (a Hong Kong limited liability partnership) and Tauil & Chequer Advogados (a Brazilian law partnership) (collectively, the “Mayer Brown Practices”). The Mayer Brown Practices are established in various jurisdictions and may be a legal person or a partnership. PK Wong & Nair LLC (“PKWN”) is the constituent Singapore law practice of our licensed joint law venture in Singapore, Mayer Brown PK Wong & Nair Pte. Ltd. More information about the individual Mayer Brown Practices and PKWN can be found in the Legal Notices section of our website.

    “Mayer Brown” and the Mayer Brown logo are the trademarks of Mayer Brown.

    Attorney Advertising. Prior results do not guarantee a similar outcome.

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  • Chinese astronauts beef up Tiangong space station’s debris shield during 6.5-hour spacewalk (video)

    Chinese astronauts beef up Tiangong space station’s debris shield during 6.5-hour spacewalk (video)

    Chinese astronauts added more debris shielding to the Tiangong space station during a 6.5-hour spacewalk on Friday (Aug. 15), according to state media.

    Two astronauts from the three-person Shenzhou 20 mission ventured outside Tiangong to do the spacewalk, which concluded Friday at 9:27 a.m. EDT (1447 UTC, or 10:47 p.m. in Beijing). It was at least the second effort for the crew to put “debris protection” devices on the three-module space station, following similar work on May 22.

    Taikonauts Chen Dong and Wang Jie also inspected and maintained equipment on the exterior of Tiangong, among other duties, the China Manned Space Agency (CMSA) said, according to the state-run broadcaster CCTV.

    A Shenzhou 20 astronaut performs a spacewalk outside China’s Tiangong space station on Aug. 15, 2025. (Image credit: CCTV)

    It was Dong’s sixth spacewalk — the most by any Chinese astronaut, CMSA officials said. Assisting the duo from inside Tiangong was Chen Zhongrui, the other member of Shenzhou 20.

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  • ‘Hacks’ Team On Late-Night TV And Impact On Season 5

    ‘Hacks’ Team On Late-Night TV And Impact On Season 5

    The Late Show with Stephen Colbert was canceled less than two months after Late Night with Deborah Vance suffered a similar fate on HBO Max’s Hacks.

    It’s a fate that has not gone unnoticed by the stars and creators of the latter.

    “What’s happening in late-night happened on the show. Deborah left the show and in the world of Hacks, the franchise ended, so it’s very weird that this is happening with Stephen Colbert right now because a lot of our season [four] was building up to that moment,” Paul W. Downs, who is a co-creator and co-showrunner of the series who also plays manager Jimmy, told Deadline.  

    Speaking at the Deadline Contenders at HBO Max event in Hollywood, Downs added that it’s been a “surreal moment for us, in light of what’s going on.”

    Watch the panel conversation here.

    But there’s good news for Jean Smart’s Vance as the show heads into Season 5, which is currently being written. “A lot of our Season 5 is going to be about her sort of reinventing herself and rewriting her legacy after she’s been blamed for the death of late-night,” he said.

    Downs was joined at the event by Lucia Aniello and Jen Statsky, who co-created and co-showrun Hacks, as well as Hannah Einbinder, who plays Ava, and Smart, who appeared virtually. The event also included scripts from Hacks as well as music inspired by the series and costumes from the show, which TV Academy voters could peruse in between sessions. There was also a conversation with a number of the below-the-line folk from Hacks including cinematographer Adam Bricker, costume designer Kathleen Felix-Hager, casting director Linda Lowy, production designer Rob Tokarz and editor Susan Vaill.

    In the show’s ninth episode, after having a sex-pest movie star on as a guest, Ava leaks the fact that a joke was cut to protect his reputation. This leads Vance to quit live on air in a special post-Oscars episode.

    Aniello said, “We wanted to explore less so the exact what is late-night in this moment, even though we do explore that, but we really wanted to explore who is Deborah now, hosting late-night. It’s more interesting to explore the relationship with Ava in making this and of course, there is the battle of art, commerce and what happens with Bob Lipka.”

    “We have a very optimistic perspective about the industry. What Deborah does in ‘A Slippery Slope’ — the ninth episode — when she leaves late-night, she does it because she wants to fight for an industry that works better for artists, and as a comedian, she doesn’t want to let herself be censored and capitulate to this tech company and her corporate overlords. We try to make it feel aspirational. We wish there were a female late-night host. We wish there was someone who stood up to corporate greed the way that Deborah does. It’s wish fulfillment,” added Downs.

    Smart said that she loved watching Johnny Carson and Steve Allen host The Tonight Show when she was growing up. “I was very excited when I found it was going to be hosting the late-night show. It’s always something that I thought would be great fun, and for somebody like Deborah, it’s the perfect fit. She has control. She’s running a party. But also, too, because it was something that was unreachable for women, that made it more enticing for her,” she added.

    Einbinder’s first entry into the business was doing a stand-up set on The Late Show with Stephen Colbert. She was also the youngest comedian to ever do a set on the CBS show and was the last onstage set for over a year as a result of the pandemic. “It was so meaningful. It’s an institution that has meant so much, and it’s such a vehicle for so many artists. We all have people in the comedy community that came up through the late-night systems. It is cool and fun to do it that justice. It was really an honor,” she said.

    In fact, Statsky interned at Saturday Night Live and Late Night with Conan O’Brien before landing a full-time job on Late Night with Jimmy Fallon.

    Late Night was my first official comedy writing job. I was 24 years old. I was scared out of my mind and it really forged in fire in terms of how those shows are made. When the three of us starting writing the season, we wanted to pay homage to what it’s like to host a late-night show, what a challenge that is, but also what it’s like to write a late-night show, make your show five days a week. We wanted to show just how hard these shows are to make and how much work goes into it,” she said.

    In the season, Einbinder’s Ava quits after finding out that the writers were splurging on fancy lunches, on her dime, but not before throwing a $70 branzino at the window. Statsky was asked who actually hurled the fish. “It was a different kind of fish,” she joked.

    Season 4 is clearly a homage to a genre that is struggling, but it’s also a homage to Los Angeles. Vance’s L.A. home was a house in Altadena that was affected by the wildfires earlier this year, and while some of the season was shot in Singapore and Las Vegas, there’s a lot of L.A., including a memorable plotline about Ava moving into the Americana.

    Statsky joked, “I spent a lot of time at the Americana. It’s amazing. I’ve always wanted to live there, yeah, because I love the Cheesecake Factory. That’s it, actually.”

    “We’re fighting for doing this the way we think it should be done. We’re lucky to make the show. We want to keep production here in Los Angeles. We want to keep this city and Hollywood working the way it has been for many years, and we feel lucky to be a part of doing that,” she added.

    The team also paid tribute to some of the fantastic guest stars this season including Julianne Nicholson, who plays a cocaine-snorting TikTok star who gets famous as Dance Mom, except she’s not actually a mother; and Jimmy Kimmel, who kicks off at Vance for attempting to lure Kristen Bell onto her show even though he “got full custody when Conan died.”

    Smart was charmed by both. “They both did performances that we did not see coming. Jimmy, Mr. Nice Guy, was so awful to Deborah and so hilarious and so shocking, that was a riot, and Julianne, no one’s ever seen Julianne like that. She’s amazing,” she said.

    Hacks, which has been renewed for Season 5, scored 14 Emmy nominations this year including Outstanding Comedy Series, which it won last year.

    The series, which also stars Megan Stalter, Carl Clemons-Hopkins, Mark Indelicato and Rose Abdoo, along with Dan Bucatinsky, Helen Hunt, Tony Goldwyn, Kaitlin Olson, Jane Adams, Lauren Weedman, Christopher McDonald, Poppy Liu, Lorenza Izzo, Johnny Sibilly, Paul Felder, Polly Draper, Luenell and Aristotle Athari, is produced by Universal Television. It is executive produced by Downs and Aniello via their Paulilu banner, Statsky via First Thought Productions, as well as Michael Schur via Fremulon, David Miner for 3 Arts Entertainment, Morgan Sackett and Joe Mande.

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  • Joe Caroff, designer of James Bond 007 logo and countless iconic film posters, dies aged 103 | James Bond

    Joe Caroff, designer of James Bond 007 logo and countless iconic film posters, dies aged 103 | James Bond

    The graphic designer responsible for the 007 gun logo as well as countless classic film posters has died, aged 103.

    Joe Caroff, whose work can be seen on the posters for films including West Side Story, A Hard Day’s Night, Last Tango in Paris, Cabaret, Manhattan and The Last Temptation of Christ, died on Sunday.

    His sons, Peter and Michael Caroff, told the New York Times he been under hospice care at his home in Manhattan, one day short of his 104th birthday.

    ‘I want a design to be effervescent’ … Joe Caroff. Photograph: Simone Bloch

    Caroff worked on more than 300 campaigns during his career, but his first two commissions turned out to be among his most enduring – and lucrative.

    First, United Artists executive David Chasman hired him to design the poster for West Side Story (1961). The better to suggest rough brickwork, Caroff scuffed the lettering, then added fire escapes and perching balletic dancers.

    Adapting the font to suit the material became a trademark. Other key examples include his poster for Manhattan (1979), one of more than a dozen collaborations with Woody Allen. In that image, Caroff assembled silhouettes of recognisable New York skyscrapers, including the Empire State Building, Chrysler building and the twin towers to spell out the word “Manhattan”.

    The second task assigned to Caroff by Chasman was to design a letterhead for the publicity release for the first Bond film, Dr No, in 1962.

    “He said, ‘I need a little decorative thing on top,’” Caroff recalled in 2021. “I knew [Bond’s] designation was 007, and when I wrote the stem of the seven, I thought, ‘That looks like the handle of a gun to me.’ It was very spontaneous, no effort, it was an instant piece of creativity.”

    Caroff’s 1961 poster for West Side Story. Photograph: Pictorial Press Ltd/Alamy

    Taking inspiration from Ian Fleming’s favourite gun, a Walther PPK, Caroff extended the image with a barrel and trigger and was paid $300 – a fee never increased by any residuals or royalties.

    As with much of his work, the logo was also uncredited, and Caroff never received the public acclaim or name recognition of his close contemporary, Saul Bass.

    Other key posters included Sergio Leone’s A Fistful of Dollars (1964) and For a Few Dollars More (1965), as well as Last Tango in Paris (1972), Rollerball (1975), An Unmarried Woman (1978) and Gandhi (1982).

    As well as working on graphics and posters, Caroff created a number of opening title sequences, including those for Richard Attenborough’s A Bridge Too Far (1977), Volker Schlöndorff’s Death of a Salesman (1985), and Martin Scorsese’s The Last Temptation of Christ (1988).

    He sought above all else “effervescence” in his work, he said in the 2022 TCM documentary By Design: The Joe Caroff Story. “I want it to have a life, it doesn’t want to lie there flat.”

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  • Wembley Park and Pantone honor hit Coldplay track with new installation – The Architect’s Newspaper

    1. Wembley Park and Pantone honor hit Coldplay track with new installation  The Architect’s Newspaper
    2. Wembley Park Unveils ‘Yellow 25’ Pantone Art Installation Inspired By Coldplay Hit  Forbes
    3. Three London pop ups Coldplay fans won’t want to miss during Wembley residency  LondonWorld
    4. Jane Boddy Creative Director at the Pantone Color Institute talks Yellow, colour and feeling  Art Plugged
    5. How to find the Coldplay ‘Yellow’ steps in Wembley during their London shows  MyLondon

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  • Could A Specificity Emphasis for MRI-Based T-Staging Reinvent Staging for Prostate Cancer?

    Could A Specificity Emphasis for MRI-Based T-Staging Reinvent Staging for Prostate Cancer?

    Assessing a variety of key considerations in prostate cancer imaging with MRI, the authors of a new review emphasize a reevaluation of specificity with respect to its impact with extraprostatic extension (EPE) prediction and correlation with long-term outcomes.

    Here are five pertinent takeaways from the prostate MRI review, which was recently published in the European Journal of Radiology.

    1. Is tumor diameter or tumor volume a better predictor for EPE? While a recent meta-analysis revealed comparable specificity at 75 percent for tumor diameter vs. 72 percent for tumor volume, researchers pointed out a 15 percent higher sensitivity rate (77 percent vs. 62 percent) and 8 percent higher AUC for tumor volume prediction of EPE.

    Emphasizing that tumor volume offers a better indication of the “overall burden and spatial extent of disease,” the review authors noted that each 1 mL increase in volume has been correlated to a 22 percent increase in risk for future metastatic disease over a five-year period for patients with localized PCa.

    The above MRI case involved a PI-RADS 5 presentation with extraprostatic extension (EPE). The authors of a new prostate MRI review emphasize a closer look at the impact of specificity and its impact on EPE prediction. (Images courtesy of RSNA.)

    2. Can neurovascular bundle asymmetry (NVB) improve clarity with ambiguous PCa cases? While neurovascular bundle asymmetry (NVB) is commonly excluded from MRI scoring systems due to poor inter-reader reproducibility and sensitivity rates ranging between 20 to 30 percent, multiple studies have noted higher than 95 percent specificity for EPE, according to the review authors.

    “ … When clearly present, NVB asymmetry can serve as a valuable confirmatory finding in otherwise ambiguous cases, supporting a specificity-focused approach that (prioritizes) avoiding overtreatment rather than pursuing equivocal signs of disease,” wrote lead review author George Agrotis, M.D., Ph.D., who is affiliated with the Netherlands Cancer Institute in Amsterdam, Netherlands, and colleagues.

    3. Does the capsular contrast enhancement sign (CES) have prognostic implications for EPE? The review authors acknowledged the rare nature of CES (presenting in 10 percent of patients with PCa) and reported sensitivity, ranging from low (17 percent) to moderate (55 percent), for EPE. However, they also noted specificity ranging from 87 to 100 percent and significant correlation with higher ISUP grade (> 4), lymphovascular invasion and perineural invasion.

    These findings position CES as a highly specific, reproducible, and visually distinctive MRI marker, particularly valuable in posterior peripheral zone tumors,” emphasized Agrotis and colleagues. “Despite its limitations — such as the paucity of studies investigating this imaging finding and its rarity resulting in low sensitivity and generalizability, it serves as a strong rule-in sign of EPE and may offer important prognostic information.

    4. Assessing the role of frank EPE. Characterized by MRI findings such as capsular breach, fat plane obliteration, periprostatic tumor mass or direct invasion of neighboring structures, frank EPE has low sensitivity and occurs in less than 15 percent of PCa cases.

    However, the review authors maintained that frank EPE offers nearly perfect specificity and inter-reader concurrence for T3a disease.

    “While an uncommon imaging feature, (the presence of frank EPE) should guide staging and surgical planning with high confidence,” maintained Agrotis and colleagues.

    5. How significant is PCa tumor zone location with EPE? In cases involving tumor capsule contact length (TCCL) ranging between 1 to 20 mm, the review authors noted research demonstrating a 25 percent lower rate of EPE with anterior prostate tumors in comparison to posterior prostate tumors (28 percent vs. 53 percent).

    However, the researchers also acknowledged a higher rate of positive surgical margins (PSMs) with anterior prostate tumors. Deficiency of the prostatic pseudocapsule at the apex is a key consideration in these cases, according to the review authors.

    While noting moderate sensitivity, the researchers cited research showing that radiological apical tumor involvement (radATI) has over 3.5 times the risk for apical PSM and over a sixfold higher risk for biochemical recurrence.

    “While anterior tumors overall are less likely to exhibit capsular breach, MRI features such as tumor contact length still hold predictive value and warrant careful preoperative evaluation due to the increased risk of apical positive surgical margins and adverse oncologic outcomes,” added Agrotis and colleagues.

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  • Alcaraz extends Big Titles lead over Sinner with Cincinnati victory – ATP Tour

    1. Alcaraz extends Big Titles lead over Sinner with Cincinnati victory  ATP Tour
    2. Cincinnati Open: Jannik Sinner to face Carlos Alcaraz in final  BBC
    3. ~^^Cincinnati Open Tennis Final 2025 Live Free on Tv  SNNewsWatch.com
    4. How the Sinner-Alcaraz Cincinnati final could prove pivotal in No. 1 battle entering US Open  ATP Tour
    5. Cincinnati Open 2025 Prize Money: How much will the winner of Alcaraz vs Sinner earn at the Masters 1000?  MARCA

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  • The nature of phantom dark energy and its relation to time crystals

    We need to show that the region of time crystals bounded by the turning points, given by the cusps of the conjugate momentum, corresponds to stable bound states.

    Before time crystals were discovered, authors of4 who studied this class of Lagrangians in the context of k-essence naturally interpreted the boundary of the time crystal with a terminating singularity since, as we will see next, the speed of sound diverges there. They relied on Einstein equations, to conclude from Friedman’s equation and the diverging speed of sound at the boundary, that the expansion of the universe terminates abruptly when the field reaches its boundary value \(\phi _t\).

    In fact, as shown a few years later in2,3,10 when time crystal solutions were discovered, time crystals are stable bound state solutions and their boundary at \(\phi =\phi _t\) behaves like a brick wall potential for the field, namely as the field approaches its boundary, the speed of sound squared diverges, implying that the field simply reverses its momentum there while all the time conserving the energy thus preserving the bound state. In this work, the phantom dark energy fluid is collections of these bound states, of the time crystals, and we show next that the expansion of the universe does not suffer a terminating singularity. Rather, it continues into an accelerated expansion until doomsday: the Big Rip.

    Let’s estimate the speed of sound squared and show that \(C_s^{2}>0\) everywhere in the time crystal field region with \(\phi \le \phi _t\) and it diverges at the boundary \(\phi _t\). In other words, the bound state structure is stable against small perturbations and the field cannot break the crystal structure to jump over values higher than its orbit \(\dot{\phi _t}\) without investing a large amount of work and energy to break the crystal-bound state, because at the boundary the speed of sound squared \(C_s^2 -> \infty\) at \(\dot{\phi } -> \dot{\phi _t}\). At the boundary, the field bounces back by reversing its momentum and remains confined within the well-behaved bound state solutions. The diverging speed of sound at the boundary simply serves to reinforce the stability of the crystal by keeping the field bound within the crystal regime despite the accelerated expansion of the universe, discussed in the context of the field’s equation of motion above.

    Actually, since the fluid is a collection of bound state crystals, we expect to find the speed of sound to be not only positive but to be \(C_{s}^{2} \ge 1\) characteristic of the crystalline structures. If such a speed of sound is found observationally, it would be an indicator of a crystalline type of dark energy. The relation of the speed of sound to background perturbations, implies that gravitational collapse of background perturbations into dark matter will be highly dampened, and none of the symmetries, such as Lorentz invariance, are violated, as explained in detail in6,9.

    The sound speed squared \(C_s^2\) for an ideal fluid with a stress energy tensor

    $$\begin{aligned} T_{ab} = \rho u_{a} u_{b} + g_{ab}(\rho + p) \end{aligned}$$

    (10)

    with \(u_a\) the four vector normalized to unity and \(g_{ab}\) the metric of the FRW universe, is defined as:

    $$\begin{aligned} C_s^2 = \frac{p’_X}{\rho ‘_X} = \frac{\mathcal {L’}_X}{\mathcal {H’}_X}. \end{aligned}$$

    (11)

    where the subscript \(X\) indicates derivatives with respect to that variable. Given the Lagrangian and Hamiltonian expressions in Eq. (1) and Eq. (4), in the general non-canonical case the speed of sound is:

    $$\begin{aligned} C_s^{2} = \frac{g'(X)}{ ( g'(X) + 2 X g” (X) )} \end{aligned}$$

    (12)

    The stability condition requires that the speed of sound is positive, \(C_{s}^{2}>0\). The latter, in combination with the condition from the phantom equation of state \(g'(X)\le 0\), and from Eq. (12) implies that \(g'(X) + 2X g”(X) \le 0\). Given the stability condition of the fluid, \(g”(X)>0\), and phantom behavior \(g'(X) <0\) naturally results not only in the speed of sounds being positive but, furthermore, in \(C_{s}^{2} \ge 1\), as can be seen from Eq. (12).

    Note from the Hamilton equations, Eq. (6), that the exact same condition that minimizes kinetic energy \(\mathcal {H’}_X =0\) at \(\dot{\phi } = \pm \dot{\phi }_t\) and gives the turning points of the time crystals, also enters in the denominator of the expression for the speed of sound squared, Eq. (11). Therefore, given that the nominator \(\mathcal {L’}_{X} < 0\) for the phantom dark energy fluid (\(g'(X) < 0\) in Eq. (12)), it can be clearly seen that the speed of sound squared will diverge at the boundary as expected

    $$\begin{aligned} C_s^2 =\frac{\mathcal {L’}_X}{\mathcal {H’}_X} = \infty \quad \textit{at}\quad \dot{\phi } =\pm \dot{\phi }_t \end{aligned}$$

    (13)

    Since\(\mathcal {H’}_X =0\) is the requirement for minimizing the energy along the orbit and it defines the time crystal, with turning points at \(\dot{\phi }_t \ne 0\) which break the time translation symmetry, a consequence of the fact that the crystal has motion as a whole. The turning points \(\phi _t\) with the diverging speed of sound squared define a brick wall in field space, an upper bound for the dark energy fluid defined by the non-canonical field \(\phi\) which is confined to take values within its bound state, the time crystal. Energy is conserved at the turning points as the field reverses momentum, therefore the expansion of the universe does not terminate abruptly. Instead the field is forced to oscillate within the time crystal region.

    A numerical study of potential observational signatures, including metric perturbations, requires selecting a class of models and it will be presented in a forthcoming paper. Hence, we can draw some general remarks regarding perturbation around time crystals. For simplicity, we will keep the metric perturbations frozen and set \(f(\phi ) =1\). Then, an approximate analysis of the scalar field perturbations \(\delta \phi (t,x)\) coupled to gravity on an accelerated expanding FRW background, with Hubble parameter \(H\), reveals stability, in part due to the periodic nature of the crystals as we show below, as well as the positive speed of sound squared and the dominant role of the Hubble drag term. For the cosmic fluid made of time crystals, where the Hamiltonian is identified with the energy density, \(\rho = {\mathcal {H}}\) and pressure with its Lagrangian \(p= {\mathcal {L}}\), the perturbation equation to first order is

    $$\begin{aligned}&\delta \ddot{\phi } – \frac{C_{s}^{2}}{a^2} \delta \phi _{,ii} + 3H \delta \dot{\phi }\nonumber \\&\quad +\left( 3 \frac{g”}{g’ + 2 X g”} \ddot{\phi } \dot{\phi }+ \frac{g”’}{g’ + 2 X g”}\ddot{\phi }\dot{\phi }^3 \right) \delta \dot{\phi }\nonumber \\&\quad + \frac{V_{\phi \phi }}{g’ + 2X g”} \delta \phi =0 \end{aligned}$$

    (14)

    where the index \(\prime\) mean derivative with respect to \(X\) and\(i\) derivative with respect to the spatial variable \(x,y,z\). (Notice that the denominator in the last three terms is simply \(\rho ‘_{X} = g’ + 2Xg”.\)) Rewriting it in term of Fourier modes, the second term in Eq.(14) becomes \(-\frac{C_{s}^{2} k^{2}}{a^2} \delta \phi\), where \(C_{s}^2\) is the speed of sound squared which is positive. Due to the periodic nature of the crystal terms, those terms containing odd power of \(\dot{\phi }\) average to zero, that is \(<\dot{\phi }> \simeq 0 , <\dot{\phi }^3> \simeq 0\), therefore the terms in the round brackets in Eq.(14) average to zero. Therefore Eq. (14) becomes

    $$\begin{aligned} \delta \ddot{\phi } + 3H \delta \dot{\phi } + \frac{C_{s}^{2} k2}{a^2} \delta \phi + \frac{V_{\phi \phi }}{g’ + 2 Xg”} \delta \phi \simeq 0\end{aligned}$$

    (15)

    Specific conclusions require a specific model. However it is possible to draw some general conclusions. For example, the Hubble drag term dominates over the potential term for any reasonable potential, as shown in the previous section counting powers of \(\frac{1}{a(t)}\) in their ratio; the odd powers of \(\dot{\phi }\) average to zero due to the oscillating nature of the crystal, simplifying Eq.(14); while \(\rho _X\) will average to some finite number given by the parameters of the specific crystal model. Besides, the crucial factor for stability of any model is the speed of sound squared being positive. The solution to the above simplified equation Eq. (15) is the familiar under-damped decaying pendulum solution.

    To remove any concern, about the longest super-horizon wavelengths, where the small \(V_{\phi \phi }\) term may play a negative role on stability, let us now look at the perturbation energy to second order,

    $$\begin{aligned} \delta ^{2}E = \frac{\rho _X}{2}\left[ \delta \dot{\phi }^2 + \frac{C_{s}^{2} k^2 }{a^2} \delta \phi ^2 + \frac{V_{\phi \phi }}{\rho _X} \delta \phi ^2 \right] \end{aligned}$$

    (16)

    With all the caveats of the Hubble drag term dominating, replacing an approximate decaying solution from the perturbations equation (\(\delta \phi (t,x) \simeq e^{-\gamma t -i k x} cos(\Gamma t)\) where \(\gamma , \Gamma\) are given by a combination of time dependent \(H, C_{s}^2,\) and \(m^2 \simeq V_{\phi \phi }\), when solving Eq. (15)), the rate of change of perturbations energy of (16) over time is roughly \(d (\delta ^{2}E)/dt \simeq – 6 H \delta \dot{\phi }^2 <0\) which is negative showing that no energy is taken from the homogeneous mode energy, \(\rho\).

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  • Study suggests probiotics may suppress antibiotic resistance genes in preterm infants

    Study suggests probiotics may suppress antibiotic resistance genes in preterm infants

    A small UK study of preterm infants is shedding new light on the impact of antibiotics and probiotics on the infant gut microbiome.

    The study, published last week in Nature Communications, found that among a cohort of very low birth weight (VLBW) infants, those who received probiotic supplements had fewer antibiotic-resistance genes (ARGs) and multidrug-resistant (MDR) pathogens in their gut than those who didn’t, even when they also received antibiotics. The infants who received probiotics also had a higher abundance of beneficial bacteria.

    The authors of the study say the findings highlight the role that probiotics could play in antimicrobial stewardship and infection control in vulnerable preterm infants.

    “Our paper shows how beneficial this intervention can be for babies born prematurely to help them give their gut a kickstart, and reduce the impact of concerning pathogens taking hold,” lead study author Lindsay Hall, PhD, chair of microbiome research at the University of Birmingham, said in a university press release.

    Antibiotic exposure common in preterm infants

    For the study, Hall and colleagues from the University of Birmingham, Quadrum Institute Bioscience, and Imperial College London analyzed the gut microbiomes of 34 VLBW infants who were all exclusively fed human milk. The infants were split into two groups: the probiotics-supplemented (PS) cohort and the non–probiotic-supplemented (NPS) cohort. 

    The infants in the PS group received probiotics containing Bifodobacterium bifidum and Lactobacillus acidophilus, two species of beneficial bacteria commonly used in probiotics. Some infants in both cohorts also received empiric benzylpenicillin and gentamicin, while others had no antibiotic exposure.

    Our paper shows how beneficial this intervention can be for babies born prematurely to help them give their gut a kickstart, and reduce the impact of concerning pathogens taking hold.

    As the authors explain, roughly 40% of neonatal intensive care units (NICUs) in the United Kingdom provide probiotic supplementation to VLBW infants, who have underdeveloped immune systems and are routinely administered broad-spectrum antibiotics to ward off infections with drug-resistant pathogens. Probiotics are used to counter the effects of early antibiotic exposure, which can disrupt the normal development of the infant gut microbiome and has been associated with higher levels of ARGs in preterm infants.

    “Importantly, probiotics have also been observed to reduce the abundance of ARGs in the gut microbiota of preterm infants, bringing it closer to levels seen in full-term infants,” the authors wrote.

    Using shotgun metagenomic sequencing, the researchers analyzed infant fecal samples, assessing microbiome species and strain dynamics, along with the effects of probiotics and antibiotics, during the first 3 weeks of life. Shotgun metagenomic sequencing involves taking the DNA out of all the bacteria in the samples, breaking it into small pieces, and analyzing all of the pieces.

    More beneficial bacteria, fewer ARGs in probiotic recipients

    The analysis revealed that the gut microbiomes of the PS infants were notably different from those of the NPS infants, with the former dominated by Bifidobacterium and the latter dominated by pathobionts (species that under certain conditions can become pathogenic) such as Klebsiella pneumoniae, Escherichia coli, and Staphylococcus epidermis. Another potentially pathogenic species, Enterococcus faecalis, was prominent in the gut microbiota of both groups.

    The abundance of ARGs was also significantly higher in NPS infants than PS infants across the first 3 weeks. And genomic analysis of ARGs found in potentially pathogenic species in each cohort indicated that those in the NPS infants more frequently exhibited MDR characteristics. 

    “The presence of these ARGs, underscores the potential for reduced antibiotic efficacy in this vulnerable population and highlights the need for careful and improved antibiotic stewardship in NICU settings,” Hall and colleagues wrote.

    In addition, when the researchers compared ARG profiles in the antibiotic versus control groups within each cohort, they found that both the antibiotic-treated and control infants in the NPS group had higher ARG counts than their counterparts in the PS, a finding they say suggests a “potential ARG-suppressive effect of B. bifidum in the preterm gut.”

    “We have already shown that probiotics are highly effective in protecting vulnerable preterm babies from serious infections, and this study now reveals that these probiotics also significantly reduce the presence of antibiotic resistance genes and multidrug-resistant bacteria in the infant gut,” said Hall.

    The analysis also found, however, that while there were a greater number of plasmids—mobile pieces of DNA that carry ARGs and other resistance mechanisms—in the NPS infants compared with the PS cohort, even high levels of Bifidobacterium did not prevent the transfer of plasmids carrying ARGs between bacteria. The finding was revealed in an ex vivo experiment that simulated the neonatal gut environment and showed horizontal gene transfer (HGT) between strains of Enterococcus isolated from the infants.

    That finding is significant because antibiotic exposure can create a selection pressure that favors ARG-carrying plasmids. So even if children who receive probiotics are carrying fewer ARGs, those ARGs could still proliferate in their gut if they’re exposed to antibiotics.

    “This emphasises the need for further studies to evaluate the role of probiotics not only in microbial colonisation but also in their potential impact on HGT dynamics, particularly in environments where antibiotics are heavily used,” the authors wrote.

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