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  • Former Wimbledon semi-finalist Musetti suffers shock first-round defeat – ATP Tour

    1. Former Wimbledon semi-finalist Musetti suffers shock first-round defeat  ATP Tour
    2. ATP Wimbledon Basilashvili N. – Musetti L. 🧠 Form & Context Lorenzo Musetti 🔥 Slam-level consistency: Musetti has reached at least the quarterfinals in three of his last four Grand Slams, including a semifinal run at Roland Garros just weeks ago. 🌱 Grass pedi  x.com
    3. Andreeva vs. Sherif Prediction at the Wimbledon – Tuesday, July 1  Bleacher Nation
    4. Tennis, ATP – Wimbledon 2025: Basilashvili gets past Musetti  tennismajors.com
    5. Lorenzo Musetti vs Nikoloz Basilashvili Head-to-Head Record, Preview, Prediction, and Betting Odds for Wimbledon 2025 First Round  The Playoffs

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  • China's Innogen expects to complete weight-loss drug trials next year – Reuters

    1. China’s Innogen expects to complete weight-loss drug trials next year  Reuters
    2. Novel GLP-1 Agonist Promotes Safe and Effective Weight Loss  Medscape
    3. Chinese Biotech Showcases Challenger to Eli Lilly’s Obesity Drug  Bloomberg
    4. Data from the Phase 2 Clinical Trial of CX11/VCT220 in China Presented at ADA 2025  GlobeNewswire
    5. ADA: Ecnoglutide Yields Superior, Sustained Reduction in Body Weight  Endocrinology Advisor

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  • Ancient DNA reveals rare leprosy strain in the Americas thousands of years before European contact

    Ancient DNA reveals rare leprosy strain in the Americas thousands of years before European contact

    In a discovery that overturns old suppositions about the origin of leprosy, researchers have recovered two extremely well-preserved genomes of Mycobacterium lepromatosis—a rare and severe form of bacteria that causes Hansen’s disease—from 4,000-year-old Chilean human skeletons. The finding is the first ancient genetic evidence of this form of leprosy in the Americas and suggests that the disease emerged on the continent independently, centuries before the arrival of Europeans.

    Cranium of a leper, showing deformed eye sockets, nose, jaw, and chin. On display at the Ribes Vikinger Museum, Denmark. Credit: Cnyborg / CC BY-SA 3.0

    The skeletons, unearthed at Chile’s Atacama Desert archaeological sites of El Cerrito and La Herradura, belonged to two adult males who lived around 2000 BCE. The skeletons bore signs of leprosy, such as widened nasal cavities and thickening of the hand bones. When scientists studied the skeletons, they were surprised to find highly intact M. lepromatosis genomes, with better DNA preservation than in many modern samples.

    While Mycobacterium leprae has long been known to be the dominant cause of Hansen’s disease—and is found in archaeological remains all over Europe and Asia dating back 5,000 years—M. lepromatosis was only identified in 2008 and is still rare today. This form of leprosy is associated with the most severe manifestations of the disease, such as diffuse lepromatous leprosy (DLL) and the potentially fatal Lucio’s phenomenon.

    The two recovered genomes indicate that M. lepromatosis split from M. leprae approximately 26,800 years ago, with the American lineages diverging around 12,600 years ago—presumably coinciding with early human migration into South America. Importantly, the ancient Chilean strain has 94 unique mutations not found in modern genomes, suggesting long-standing isolated evolution.

    Ancient DNA reveals rare leprosy strain in the Americas thousands of years before European contact
    Children sitting beside a collection of human remains at Paco Leper Cemetery, Manila, Philippines. Credit: National Museum of Health and Medicine / CC BY 2.0

    This deep divergence means that Hansen’s disease did not arrive with European colonists to the Americas, as previously believed, but perhaps originated or was independently introduced much earlier. “So far, the evidence points in the direction of an American origin,” said Kirsten Bos, group leader for Molecular Paleopathology at the Max Planck Institute for Evolutionary Anthropology, “but we’ll need more genomes from other time periods and contexts to be sure.”

    The study also raises broader questions about disease evolution and the limitations of our historical knowledge.

    Today, M. lepromatosis remains rare, largely confined to Mexico and the Caribbean, but it has also been found in red squirrels in Ireland and the UK, highlighting possible zoonotic transmission routes. Although new cases are limited, finding it in ancient Chile provides evidence that the pathogen also circulated more widely and might have played a significant role in pre-Columbian health.

    This finding showcases the ability of ancient DNA studies to reveal the lost epidemics of the past—pathogens that shaped civilizations and disappeared without a trace, until now.

    More information: Ramirez, D. A., Sitter, T. L., Översti, S., Herrera-Soto, M. J., Pastor, N., Fontana-Silva, O. E., … Bos, K. I. (2025). 4,000-year-old Mycobacterium lepromatosis genomes from Chile reveal long establishment of Hansen’s disease in the Americas. Nature Ecology & Evolution. doi:10.1038/s41559-025-02771-y


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  • Ancient DNA reveals rare leprosy strain in the Americas thousands of years before European contact

    Ancient DNA reveals rare leprosy strain in the Americas thousands of years before European contact

    In a discovery that overturns old suppositions about the origin of leprosy, researchers have recovered two extremely well-preserved genomes of Mycobacterium lepromatosis—a rare and severe form of bacteria that causes Hansen’s disease—from 4,000-year-old Chilean human skeletons. The finding is the first ancient genetic evidence of this form of leprosy in the Americas and suggests that the disease emerged on the continent independently, centuries before the arrival of Europeans.

    Cranium of a leper, showing deformed eye sockets, nose, jaw, and chin. On display at the Ribes Vikinger Museum, Denmark. Credit: Cnyborg / CC BY-SA 3.0

    The skeletons, unearthed at Chile’s Atacama Desert archaeological sites of El Cerrito and La Herradura, belonged to two adult males who lived around 2000 BCE. The skeletons bore signs of leprosy, such as widened nasal cavities and thickening of the hand bones. When scientists studied the skeletons, they were surprised to find highly intact M. lepromatosis genomes, with better DNA preservation than in many modern samples.

    While Mycobacterium leprae has long been known to be the dominant cause of Hansen’s disease—and is found in archaeological remains all over Europe and Asia dating back 5,000 years—M. lepromatosis was only identified in 2008 and is still rare today. This form of leprosy is associated with the most severe manifestations of the disease, such as diffuse lepromatous leprosy (DLL) and the potentially fatal Lucio’s phenomenon.

    The two recovered genomes indicate that M. lepromatosis split from M. leprae approximately 26,800 years ago, with the American lineages diverging around 12,600 years ago—presumably coinciding with early human migration into South America. Importantly, the ancient Chilean strain has 94 unique mutations not found in modern genomes, suggesting long-standing isolated evolution.

    Ancient DNA reveals rare leprosy strain in the Americas thousands of years before European contact
    Children sitting beside a collection of human remains at Paco Leper Cemetery, Manila, Philippines. Credit: National Museum of Health and Medicine / CC BY 2.0

    This deep divergence means that Hansen’s disease did not arrive with European colonists to the Americas, as previously believed, but perhaps originated or was independently introduced much earlier. “So far, the evidence points in the direction of an American origin,” said Kirsten Bos, group leader for Molecular Paleopathology at the Max Planck Institute for Evolutionary Anthropology, “but we’ll need more genomes from other time periods and contexts to be sure.”

    The study also raises broader questions about disease evolution and the limitations of our historical knowledge.

    Today, M. lepromatosis remains rare, largely confined to Mexico and the Caribbean, but it has also been found in red squirrels in Ireland and the UK, highlighting possible zoonotic transmission routes. Although new cases are limited, finding it in ancient Chile provides evidence that the pathogen also circulated more widely and might have played a significant role in pre-Columbian health.

    This finding showcases the ability of ancient DNA studies to reveal the lost epidemics of the past—pathogens that shaped civilizations and disappeared without a trace, until now.

    More information: Ramirez, D. A., Sitter, T. L., Översti, S., Herrera-Soto, M. J., Pastor, N., Fontana-Silva, O. E., … Bos, K. I. (2025). 4,000-year-old Mycobacterium lepromatosis genomes from Chile reveal long establishment of Hansen’s disease in the Americas. Nature Ecology & Evolution. doi:10.1038/s41559-025-02771-y


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  • Meet Natasha Anasi-Erlingsson – the former U.S. junior all in for Iceland

    Meet Natasha Anasi-Erlingsson – the former U.S. junior all in for Iceland

    From Texas to Iceland – Natasha Anasi-Erlingsson’s football journey to the UEFA Women’s EURO 2025 has been one of a kind.

    A little more than 10 years ago, the defender never would have thought she would play at the European championships one day. At that time, the Texas-born footballer was pursuing her goals with the U.S. U23 squad and hoping to play in the National Women’s Soccer League.

    When the deal fell through, she got an offer to move to Europe. The young player ended up in Iceland, a stark contrast from the warmth of Texas where was raised by parents of Kenyan descent.

    “I looked for an agent and started looking at moves abroad. When the offer from Iceland came, initially I definitely found it a bit random. But after I did my research, I thought there was something really charming about it and I ended up taking the plunge,” she said in an interview with FIFA.com.

    “The landscape and the weather here could hardly be any more different from Texas… But I came here with the mindset of just wanting to explore and have a great time. I was lucky too that the team I joined had a real family environment and took great care of me, so I settled in and enjoyed it right from the start.”

    The now 33-year-old acclimatised quickly and ended up staying longer than expected. She married an Icelander and, in 2019, was granted citizenship and received her first call up to the national team.

    “There was a brief thought of, ‘Am I really going to do this?’ But at the same time there was no hesitation at all,” said the mother-of-two. “My roots here are so deep now that I really do feel like I’m an Icelander.

    “I’ve learned the language and my teammates are constantly praising me about how well I do with it. And I love that they all speak to me in Icelandic. Even if I ever struggle to get a word out, they just help me – they never switch to English. They’ve embraced me as an Icelander from the first minute I met them.”

    Anasi-Erlingsson is the experienced spine that Iceland will be counting on as they play in their fifth consecutive UEFA Women’s EURO. The national team, coached by Thorsteinn Halldórsson, are seeking their first win at the EUROs since 2013.

    Iceland kicks off the UEFA Women’s EURO 2025 against Finland in Group A on Wednesday, 2 July in Thun, Switzerland.

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  • Brentford hold latest fan advisory board meeting | Brentford FC

    Brentford hold latest fan advisory board meeting | Brentford FC

    Brentford held its most recent fan advisory board (FAB) meeting in June.

    FAB meetings are a part of the club’s ongoing commitment to consulting and involving fans in key decisions and are a key element of the Premier League’s fan engagement standard.

    The meeting was attended by club executives together with FAB members drawn from Bees United and Brentford Independent Association of Supporters (BIAS). The current FAB members are: Stuart Hatcher (co-chair), Don Tanswell, Chris Tate, Sharon Wright (all Bees United), Angelo Basu (co-chair), Dave Minckley, Matthew White and Allyson Woyak (all BIAS).

    The FAB focuses on off-pitch matters and provides a sounding board for the club to discuss strategic issues with fan representatives.

    A number of working groups focusing on specific topics and projects such as ticketing, food and drink, fan atmosphere and sustainability also report into the FAB, providing more detailed feedback to help steer the club’s decisions and policies.

    In the most recent meeting, the FAB discussed the club’s plans to move to digital ticketing, including detailed implementation plans and how Brentford will help fans transition to the new technology.

    The group also spoke about plans for fan consultation and involvement for the season ahead, including the suggested outline plan for the FAB meetings and ongoing working group meetings. Ahead of the meeting, an overview of the working group meetings was shared, totalling some 60 meetings over the last season.

    Fan atmosphere was also on the agenda. The group discussed how fans and fan groups could help the team by improving the atmosphere during home games at Gtech Community Stadium. Plans are in place for the fan atmosphere working group to meet ahead of the new season.

    Brentford staff also provided an update on the work that’s required to confirm that the club has met the requirements set out in the Premier League’s Fan Engagement Standard for the 2024/25 season.

    The club is required to publish a fan engagement plan and other key documents such as a revised Supporter Charter ahead of the start of the upcoming campaign.

    Read more about the points discussed at our recent FAB meeting

    Get to know your fan advisory board members

    FAB member Sharon Wright recently spoke to the club’s sustainability manager James Beale about why sustainability is so important to her and how she’s engaged with Brentford to support our efforts in this area.

    If you’d like to find out more about the work that the FAB does or have any points that you’d like to raise with them, you can send an email to [email protected] or [email protected], or contact the club via email at [email protected] and your email will be passed onto the FAB members.

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  • Sinner speeds past Nardi in Wimbledon opener – ATP Tour

    1. Sinner speeds past Nardi in Wimbledon opener  ATP Tour
    2. Wimbledon 2025 LIVE: Krejcikova vs Eala, Sinner vs Nardi on day two – watch stream, order of play, scores & updates  BBC
    3. Jannik Sinner looks to bury Roland Garros demons in bid for 1st Wimbledon title  India Today
    4. Coco Gauff vs Dayana Yastremska (7/1/25) FREE LIVE STREAM: Watch Wimbledon match online | Time, TV Channel  NJ.com
    5. Britain Wimbledon Tennis  WV News

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  • Wimbledon 2025: Sinner brushes aside Nardi in all-Italian battle, moves to second round

    Wimbledon 2025: Sinner brushes aside Nardi in all-Italian battle, moves to second round

    Top seed Jannik Sinner eased into the Wimbledon second round on Tuesday, brushing aside fellow Italian Luca Nardi in straight sets.

    Unfazed by the searing heat, Sinner barely broke sweat in a 6-4, 6-3, 6-0 victory lasting just one hour and 48 minutes on Court One.

    “I’m very happy to come back here to such a special place for me,” Sinner said.

    “Playing an Italian is very unfortunate but one has to go through and luckily it was me.”

    Sinner last week insisted his surprise decision to part with two of his coaching staff on the eve of Wimbledon would not affect his bid to win the tournament for the first time.

    He opted to move on from Marco Panichi and Ulises Badio, his trainer and physiotherapist, as he looks for a new direction following his painful French Open final loss to Carlos Alcaraz.

    READ | Elisabetta Cocciaretto stuns Jessica Pegula in first round of Wimbledon

    The pair had been employed by Sinner since September 2024, helping him retain the Australian Open crown in January and reach the Roland Garros showpiece in June.

    Asked if the decision might jeopardise his Wimbledon challenge over the next fortnight, Sinner was adamant it would be beneficial, with coaches Simone Vagnozzi and Darren Cahill still on his staff.

    On the evidence of his dominant display against Nardi the world number one, who returned from a three-month doping ban in May, will be just fine regardless of the coaching shake-up.

    “We worked a lot after Halle (grass-court tournament) on the serve and in important moments I felt I was serving very well,” Sinner said.

    “First matches are never easy, so I’m very happy with the performance. It’s a new tournament, new challenges.

    “If you don’t enjoy to play on these courts, I don’t know where you will enjoy. I will try to keep going.”

    Sinner has won three of the past six Grand Slams, but the 23-year-old blew a two-set lead and wasted three match points as Alcaraz staged a comeback for the ages to win the French Open final.

    Sinner has failed to reach the Wimbledon final in his four visits, with a last-four appearance in 2023 ranking as his best effort.

    The Italian’s Wimbledon preparations were also dented by a shock last-16 defeat against Alexander Bublik at Halle.

    Playing world number 95 Nardi for the first time, Sinner had little trouble dispatching the 21-year-old in his first Grand Slam match since that bitter defeat at Roland Garros.

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  • Turkiye evacuates more than 50,000 residents from wildfire-affected areas of Izmir province – RADIO PAKISTAN

    1. Turkiye evacuates more than 50,000 residents from wildfire-affected areas of Izmir province  RADIO PAKISTAN
    2. PM expresses sorrow over wildfires in Türkiye’s Izmir province  Ptv.com.pk
    3. Watch: Wildfires rage in Turkey as flames engulf houses  BBC
    4. Turkiye battles wildfires in Izmir for second day, 50,000 people evacuated  Al Jazeera
    5. Firefighters race to contain wildfires in western, southern Türkiye | Daily Sabah  Daily Sabah

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  • Apple weighs using Anthropic or OpenAI to power Siri in major reversal

    Apple weighs using Anthropic or OpenAI to power Siri in major reversal

    Apple Inc. is considering using artificial intelligence technology from Anthropic PBC or OpenAI to power a new version of Siri, sidelining its own in-house models in a potentially blockbuster move aimed at turning around its flailing AI effort.

    The iPhone maker has talked with both companies about using their large language models for Siri, according to people familiar with the discussions. It has asked them to train versions of their models that could run on Apple’s cloud infrastructure for testing, said the people, who asked not to be identified discussing private deliberations.

    If Apple ultimately moves forward, it would represent a monumental reversal. The company currently powers most of its AI features with homegrown technology that it calls Apple Foundation Models and had been planning a new version of its voice assistant that runs on that technology for 2026.

    A switch to Anthropic’s Claude or OpenAI’s ChatGPT models for Siri would be an acknowledgment that the company is struggling to compete in generative AI — the most important new technology in decades. Apple already allows ChatGPT to answer web-based search queries in Siri, but the assistant itself is powered by Apple.

    Apple’s investigation into third-party models is at an early stage, and the company hasn’t made a final decision on using them, the people said. A competing project internally dubbed LLM Siri that uses in-house models remains in active development.

    Making a change — which is under discussion for next year — could allow Cupertino, California-based Apple to offer Siri features on par with AI assistants on Android phones, helping the company shed its reputation as an AI laggard.

    Representatives for Apple, Anthropic and OpenAI declined to comment. Shares of Apple closed up over 2% after Bloomberg reported on the deliberations.

    The project to evaluate external models was started by Siri chief Mike Rockwell and software engineering head Craig Federighi. They were given oversight of Siri after the duties were removed from the command of John Giannandrea, the company’s AI chief. He was sidelined in the wake of a tepid response to Apple Intelligence and Siri feature delays.

    Rockwell, who previously launched the Vision Pro headset, assumed the Siri engineering role in March. After taking over, he instructed his new group to assess whether Siri would do a better job handling queries using Apple’s AI models or third-party technology, including Claude, ChatGPT and Alphabet Inc.’s Google Gemini.

    After multiple rounds of testing, Rockwell and other executives concluded that Anthropic’s technology is most promising for Siri’s needs, the people said. That led Adrian Perica, the company’s vice president of corporate development, to start discussions with Anthropic about using Claude, the people said.

    The Siri assistant — originally released in 2011 — has fallen behind popular AI chatbots, and Apple’s attempts to upgrade the software have been stymied by engineering snags and delays.

    A year ago, Apple unveiled new Siri capabilities, including ones that would let it tap into users’ personal data and analyze on-screen content to better fulfill queries. The company also demonstrated technology that would let Siri more precisely control apps and features across Apple devices.

    The enhancements were far from ready. Apple initially announced plans for an early 2025 release but ultimately delayed the launch indefinitely. They are now planned for next spring, Bloomberg News has reported.

    People with knowledge of Apple’s AI team say it is operating with a high degree of uncertainty and a lack of clarity, with executives still poring over a number of possible directions. Apple has already approved a multibillion dollar budget for 2026 for running its own models via the cloud but its plans for beyond that remain murky.

    Still, Federighi, Rockwell and other executives have grown increasingly open to the idea that embracing outside technology is the key to a near-term turnaround. They don’t see the need for Apple to rely on its own models — which they currently consider inferior — when it can partner with third parties instead, according to the people.

    Licensing third-party AI would mirror an approach taken by Samsung Electronics Co. While the company brands its features under the Galaxy AI umbrella, many of its features are actually based on Gemini. Anthropic, for its part, is already used by Amazon.com Inc. to help power the new Alexa+.

    In the future, if its own technology improves, the executives believe Apple should have ownership of AI models given their increasing importance to how products operate. The company is working on a series of projects, including a tabletop robot and glasses that will make heavy use of AI.

    Apple has also recently considered acquiring Perplexity in order to help bolster its AI work, Bloomberg has reported. It also briefly held discussions with Thinking Machines Lab, the AI startup founded by former OpenAI Chief Technology Officer Mira Murati.

    Apple’s models are developed by a roughly 100-person team run by Ruoming Pang, an Apple distinguished engineer who joined from Google in 2021 to lead this work. He reports to Daphne Luong, a senior director in charge of AI research.

    Luong is one of Giannandrea’s top lieutenants, and the foundation models team is one of the few significant AI groups still reporting to Giannandrea. Even in that area, Federighi and Rockwell have taken a larger role.

    Regardless of the path it takes, the proposed shift has weighed on the team, which has some of the AI industry’s most in-demand talent.

    Some members have signaled internally that they are unhappy that the company is considering technology from a third-party, creating the perception that they are to blame, at least partially, for the company’s AI shortcomings. They’ve said that they could leave for multimillion-dollar packages being floated by Meta Platforms Inc. and OpenAI.

    Meta, the owner of Facebook and Instagram, has been offering some engineers annual pay packages between $10 million and $40 million — or even more — to join its new Superintelligence Labs group, according to people with knowledge of the matter. Apple is known, in many cases, to pay its AI engineers half — or even less — than what they can get on the open market.

    One of Apple’s most senior large language model researchers, Tom Gunter, left last week. He had worked at Apple for about eight years, and some colleagues see him as difficult to replace given his unique skillset and the willingness of Apple’s competitors to pay exponentially more for talent.

    Apple this month also nearly lost the team behind MLX, its key open-source system for developing machine learning models on the latest Apple chips. After the engineers threatened to leave, Apple made counteroffers to retain them — and they’re staying for now.

    In its discussions with both Anthropic and OpenAI, the iPhone maker requested a custom version of Claude and ChatGPT that could run on Apple’s Private Cloud Compute servers — infrastructure based on high-end Mac chips that the company currently uses to operate its more sophisticated in-house models.

    Apple believes that running the models on its own chips housed in Apple-controlled cloud servers — rather than relying on third-party infrastructure — will better safeguard user privacy. The company has already internally tested the feasibility of the idea.

    Other Apple Intelligence features are powered by AI models that reside on consumers’ devices. These models — slower and less powerful than cloud-based versions — are used for tasks like summarizing short emails and creating Genmojis.

    Apple is opening up the on-device models to third-party developers later this year, letting app makers create AI features based on its technology.

    The company hasn’t announced plans to give apps access to the cloud models. One reason for that is the cloud servers don’t yet have the capacity to handle a flood of new third-party features.

    The company isn’t currently working on moving away from its in-house models for on-device or developer use cases. Still, there are fears among engineers on the foundation models team that moving to a third-party for Siri could portend a move for other features as well in the future.

    Last year, OpenAI offered to train on-device models for Apple, but the iPhone maker was not interested.

    Since December 2024, Apple has been using OpenAI to handle some features. In addition to responding to world knowledge queries in Siri, ChatGPT can write blocks of text in the Writing Tools feature. Later this year, in iOS 26, there will be a ChatGPT option for image generation and on-screen image analysis.

    While discussing a potential arrangement, Apple and Anthropic have disagreed over preliminary financial terms, according to the people. The AI startup is seeking a multibillion-dollar annual fee that increases sharply each year. The struggle to reach a deal has left Apple contemplating working with OpenAI or others if it moves forward with the third-party plan, they said.

    If Apple does strike an agreement, the influence of Giannandrea, who joined Apple from Google in 2018 and is a proponent of in-house large language model development, would continue to shrink.

    In addition to losing Siri, Giannandrea was stripped of responsibility over Apple’s robotics unit. And, in previously unreported moves, the company’s Core ML and App Intents teams — groups responsible for frameworks that let developers integrate AI into their apps — were shifted to Federighi’s software engineering organization.

    Apple’s foundation models team had also been building large language models to help employees and external developers write code in Xcode, its programming software. The company killed the project — announced last year as Swift Assist — about a month ago.

    Instead, Apple later this year is rolling out a new Xcode that can tap into third-party programming models. App developers can choose from ChatGPT or Claude.

    Gurman writes for Bloomberg.

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