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  • Indonesia, Saudi Arabia agree on strategic cooperation worth 27 bln USD-Xinhua

    JAKARTA, July 3 (Xinhua) — Indonesia and Saudi Arabia have agreed on business cooperation worth some 27 billion U.S. dollars in various sectors, including clean energy, petrochemical industries, aviation fuel services, healthcare, pharmaceuticals, and health technology.

    According to a press release by the Indonesian Presidential Secretariat on Thursday, the agreements were signed by private sector entities from both countries and welcomed by President Prabowo Subianto and Saudi Crown Prince Mohammed bin Salman during a bilateral meeting at Al-Salam Palace in Jeddah on Wednesday.

    In a joint statement, both leaders expressed their commitment to strengthening and expanding bilateral cooperation, particularly in investment, trade, and the digital economy, including enhanced private sector collaboration.

    They also welcomed the strengthening of defense and security cooperation, including counterterrorism, the fight against extremism, cybersecurity, and cooperation in information exchange and training.

    Both leaders affirmed the importance of enhancing cooperation in multilateral mechanisms such as the G20, the Organization of Islamic Cooperation, the International Monetary Fund, and the Non-Aligned Movement, to address global challenges.

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  • A Challenging Case of Wild-Type Transthyretin Amyloidosis (ATTR) Amyloidosis Treated With Cardiac Resynchronization Therapy

    A Challenging Case of Wild-Type Transthyretin Amyloidosis (ATTR) Amyloidosis Treated With Cardiac Resynchronization Therapy


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  • Dubai’s booming restaurant scene is feeling the heat of high costs and high failure rates

    Dubai’s booming restaurant scene is feeling the heat of high costs and high failure rates

    DUBAI, United Arab Emirates — From suspended tables to underwater lounges, some 13,000 food and drink establishments in Dubai pull out all the stops to attract customers in one of the world’s most saturated dining markets.

    They cater to all tastes and budgets. Some spots ladle out inexpensive biryani while others offer dishes dusted with edible gold.

    These are some of the ways the emirate is competing with its neighbors Saudi Arabia and Qatar for tourist dollars and, so far, it’s beating them handily. Dubai has more restaurants per capita than any major city except Paris.

    But the city-state’s booming restaurant scene is testing the limits of its growth-at-all-costs model, raising questions about how long Dubai can keep feeding its own ambitions.

    The competition is cutthroat, so presentation is key.

    “Gone are the days when it just tastes good,” said Kym Barter, the general manager of Atlantis The Palm, a resort perched on a manmade archipelago that boasts more Michelin stars than any other venue in the Middle East.

    But dazzling Dubai’s food bloggers — the most popular of whom have millions of social media followers — isn’t enough. Staying afloat means battling high rents and winning over a diverse and demanding group of consumers.

    Dubai has roughly nine expatriate residents for every Emirati citizen. Most of its private sector workers are migrants on temporary contracts, and only Vatican City has a higher share of foreign-born residents.

    Tourists, in turn, outnumber locals about five to one by some estimates, and they spend lavishly. Visitors to Dubai drop an average of over five times more than those traveling to nearby Saudi Arabia or even the U.S., according to global restaurant consultant Aaron Allen.

    Dubai is “on the right path” to becoming the world’s food capital, said Torsten Vildgaard, executive chef at FZN by Björn Frantzén. The restaurant, which runs at more than $540 a head, was one of two in Dubai to nab three Michelin stars in May.

    “We’re only seeing the tip of the iceberg of what’s to come in terms of gastronomy here,” Vildgaard added.

    With each new set of illuminated high-rises and hotels, another crop of eateries emerge, vying for patrons. The legions of construction workers powering Dubai’s progress also need affordable options.

    That growth, propped up in part by investor pressure on some of the world’s biggest chains to expand in Dubai, has created what some analysts warn is a bubble.

    “If you’re a publicly traded company like Americana, what are you supposed to do — just stop opening restaurants?” restaurant consultant Allen said, referring to the Gulf-based operator of KFC, Pizza Hut and other big franchises.

    The frenetic expansion of Dubai’s restaurant industry is part of a regional shift that has seen Gulf Arab states pour hundreds of billions of dollars into building out tourist destinations as they move away from hydrocarbons to diversify their economies. Saudi Arabia has a high-stakes, $500 billion project: a straight-line futuristic city called Neom.

    But, in a Muslim-majority region, the United Arab Emirates has gone to lengths that some consider too much of a compromise, including relaxing restrictions on alcohol that fuel its pubs and nightlife and other social reforms.

    The rapid development comes at a price. Dubai’s restaurants have a high failure rate, industry veterans say, though local authorities don’t say what the rate of closures is. In the downtown district and other prime areas, annual rents for restaurants can top $100 per square foot. That’s on a par with some of the world’s most expensive cities.

    Still, the emirate issued almost 1,200 new restaurant licenses last year, according to Dubai’s Department of Economy and Tourism. The department declined to respond to questions.

    Empty tables during peak hours are common, even in top locations. Part of the problem, managers say, is that traffic congestion is so severe that convincing diners to drive out can be a tall task.

    “I sometimes go, ‘Do I go into the restaurant right now, because I’m going to get into traffic?’’’ said Waseem Abdul Hameed, operations manager at Ravi, a Pakistani family-owned eatery famous for its official Adidas shoe line and a 2010 TV feature from Anthony Bourdain.

    He knows restaurateurs who have had to shut up shop and others who are squeezed by slim margins and increasingly reliant on delivery apps, Hameed said.

    The demand sends fleets of migrant workers racing through gridlock on motorbikes, with few protections and tight delivery windows. Emirati newspaper Khaleej Times reported the accidental deaths of 17 Dubai food couriers last year.

    The math of Dubai’s restaurant scene doesn’t add up, delivery apps and wealthy tourists notwithstanding, restaurant consultant Allen said. He cited operating expenses that have more than doubled relative to sales since 2009, when a financial crisis almost hobbled the emirate.

    Too many Dubai entrepreneurs, he put it simply, have “too much money, and they don’t know what to do besides open restaurants.”

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  • Study unveils powerful strategy to rejuvenate effectiveness of CAR T cell therapy against glioblastoma

    Study unveils powerful strategy to rejuvenate effectiveness of CAR T cell therapy against glioblastoma

    A team of researchers from the San Raffaele-Telethon Institute for Gene Therapy (SR-TIGET, Milan), led by Nadia Coltella and Luigi Naldini, has unveiled a powerful strategy to rejuvenate the effectiveness of chimeric antigen receptor (CAR) T cell therapy against glioblastoma, one of the most lethal and treatment-resistant brain tumors. The findings, published in Science Translational Medicine, highlight how gene therapy targeting immune stimulating cytokines to the tumor microenvironment (TME) and enabling their private cross-talk with CAR-T cells not only restores CAR-T killer activity but also boost a broader immune response that inhibits tumor growth and extends host survival in a preclinical glioblastoma models.

    The study builds on the prior development by the Naldini’s laboratory of a gene therapy strategy that exploit genetic engineering of hematopoietic progenitors to generate a progeny of monocyte/macrophages that selectively release their immune stimulating payload upon infiltrating a tumor. This strategy has been taken to its first-in-human clinical testing as stand-alone treatment of glioblastoma by the biotech company Genenta Science, a spin-off from the San Raffaele Institute now listed on the NASDAQ.

    “Solid tumors like glioblastoma have been notoriously difficult for CAR-T cells to penetrate and control,” explains Dr. Rossari, first author of the work, “By reprogramming a population of tumor-infiltrating macrophages to deliver cytokines directly into the tumor, we’ve morphed the immunosuppressive TME into one supportive of immune cells, thus allowing CAR T cells to better persist, become activated and attack tumor cells.”

    CAR-T cells have shown transformative results in blood cancers but have struggled in solid tumors due to the hostile, immunosuppressive TME. The team’s strategy leads to selective release of two cytokines within the TME: interferon-α (IFN-α), a pleiotropic immune stimulator that counteracts local immune suppressive cues and enforces antigen presentation and immune effectors’ activity, and an engineered mutant of interleukin-2 that can only activate a cognate mutant receptor co-introduced with the CAR into T cells, thus boosting the proliferation specifically of the administered effector engaged in fighting the tumor.

    “The private ‘cross-talk’ between genetically engineered macrophages and CAR T cells established in the TME ensures that the immune stimulants act only where needed, sparing the rest of the body from systemic toxicity, and specifically on the relevant target cells involved in the tumor attack, again preventing collateral damage and aberrant effects,” says Dr. Alvisi, co-first author of the study.

    In a mouse model of glioblastoma that mimics the pathology and immunological barriers seen in human patients, the targeted cytokines rescued the activity of CAR-T cells that, given alone, were ineffective – as mostly seen in clinical trials. In turn, the rescued CAR T cells now synergized with cytokine delivery, significantly enhancing their effect on delaying tumor growth and extending mouse survival. Strikingly, even tumors with only a fraction of cells expressing the CAR-targeted antigen B7-H3 were effectively controlled, indicating engagement of endogenous T cells on top of the CAR-T to fight the tumor.

    “We observed not only reactivation of the CAR-T cells but also the recruitment of the host’s own T cells against a wider range of tumor antigens,” says Dr. Nadia Coltella, senior co-corresponding author. “This phenomenon, known as antigenic spreading, was mostly dependent on IFN-α activity in the TME and is a key feature for creating effective immunity as it may overcome immune evasion by tumors targeted only through a single antigen by the CAR-T cells.”

    “This work represents another important step forward in our decade-long commitment to develop a novel gene and cell therapy strategy effective against tumors, as we have been able to do for several genetic diseases along the life of our institute” adds Luigi Naldini, Director of SR-TIGET and Professor at Università Vita-Salute San Raffaele. “The tumor-targeted IFN-α delivery strategy is already being evaluated as stand-alone treatment in a first-in-human phase 1/2a trial on the most aggressive type of glioblastoma (Temferon trial) led by the biotech company Genenta Science. The study has shown feasibility, safety, biological activity in reprogramming the TME and early but promising indication of therapeutic benefit, albeit limited by the small number of treated patients and the design of a phase 1 study. A combination of Temferon with CAR-T cells administration, as prompted by our new study, could in future further enhance the benefit of the treatment and broaden its efficacy to a larger fraction of patients.”

    This study was supported also by the Italian Association for Cancer Research (AIRC), the Louis-Jeantet Foundation through the Jeantet-Collen Prize for Translational Medicine to Luigi Naldini, and a research contract from Genenta Sciences.

    Source:

    Journal reference:

    Rossari, F., et al. (2025) A cross-talk established by tumor-targeted cytokines rescues CAR T cell activity and engages host T cells against glioblastoma in mice. Science Translational Medicine. doi.org/10.1126/scitranslmed.ado9511.

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  • Mercedes AMG CLA 45 S Final Edition Release Info

    Mercedes AMG CLA 45 S Final Edition Release Info

    Summary

    • Limited 2026 model features exclusive grey/yellow design and aero upgrades
    • 416 hp turbo engine, 0–60 mph in 4.0 seconds with drift mode
    • Launches early 2026 in the U.S. with enhanced interior and standard equipment

    Mercedes-AMG has announced the CLA 45 S “Final Edition”, a high-performance sendoff for the compact sport sedan, arriving in limited numbers to U.S. dealerships in early 2026. Finished in MANUFAKTUR Mountain Grey Magno, the Final Edition features bold black and yellow graphics, 19-inch matte black forged wheels with yellow accents and exclusive aerodynamic enhancements from AMG’s wind tunnel testing.

    Under the hood, the hand-built 2L turbocharged AMG engine delivers 416 hp and 369 lb-ft of torque, launching the car from 0–60 mph in 4.0 seconds. Power is distributed via an 8-speed dual-clutch transmission and AMG Performance 4MATIC+ all-wheel drive with torque vectoring and drift mode capability.

    Inside, the Final Edition sports AMG Performance seats wrapped in black MB-Tex and microfiber with yellow contrast stitching, matching details on the dashboard, doors and AMG Performance steering wheel. Unique badging, yellow-stitched floor mats and illuminated yellow AMG door sills round out the design.

    With extensive standard equipment including the AMG Night Package Plus and Aerodynamics Package Plus, the CLA 45 S “Final Edition” aims to offer both track-ready performance and refined exclusivity, marking the end of an era for AMG’s compact powerhouse.

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  • "He will be able to sleep well," says Sean 'Diddy' Comb's lawyer after rapper acquitted of sex trafficking charges – ANI News

    1. “He will be able to sleep well,” says Sean ‘Diddy’ Comb’s lawyer after rapper acquitted of sex trafficking charges  ANI News
    2. Diddy’s secret world revealed in videos and his voice notes  BBC
    3. Sean ‘Diddy’ Combs Trial Live Updates: Combs Found Not Guilty of Sex Trafficking and Convicted on Lesser Charges  The New York Times
    4. Sean ‘Diddy’ Combs convicted on prostitution counts by US jury, cleared of more serious charges  Dawn
    5. Sean ‘Diddy’ Combs trial updates: Bail denied due to ‘propensity for violence’  ABC News – Breaking News, Latest News and Videos

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  • KRK launches Kreate Series Studio Monitors — a versatile solution for producers, podcasters, and content creators alike

    KRK launches Kreate Series Studio Monitors — a versatile solution for producers, podcasters, and content creators alike

    KRK introduces the Kreate Series Studio Monitors, the newest addition to the brand’s wide range of audio offerings. The Kreate monitors bring extraordinary value and legendary KRK monitoring performance to emerging musicians, engineers, producers, and content creators. These best-in-class two-way studio monitors are designed specifically to meet the diverse needs of creatives, providing the tools necessary to reproduce every nuance of a production with astonishing clarity and accuracy. From casual playback to professional music and content production, the Kreate Series is designed to perform. The Kreate line is available through select dealers and online at krkmusic.com.

    As the brand’s newest studio monitor line, the KRK Kreate Series represents KRK’s continued commitment to innovation, accessibility, and excellence, supporting a wide range of setups and needs. Great for mixing, producing, and content creation, the Kreate monitors have a variety of key features that stand out among other monitors in their class. This includes wireless audio streaming capabilities with a pairable Bluetooth® audio input alongside balanced and unbalanced analog inputs for flexible connectivity. The monitors also have a universal voltage, switch-mode power supply for seamless global operations.

    Available in three sizes — three, five, and eight-inch — these entry-level active, two-way studio reference monitors feature a wide bandwidth, boundary and tuning EQs, new transducer designs, and Class D amplification. The Kreate Series also features useful acoustic boundary correction and tuning EQ combinations to help minimize and correct acoustic environment problems and dial in the voicing to meet specific application needs.

    “The Kreate Series offers professional-grade sound and flexible functionality that empowers emerging artists, producers, podcasters, and all creators to embrace high-quality audio at an affordable price point,” says Sterling Doak, Senior Director of Marketing for Gibson. “The monitors fill a vital space in the KRK lineup and are ideal for those who demand quality without compromise. As the new introductory solution within the portfolio, the Kreate Series will enable users to begin their creative journey with confidence.”

    With KRK Kreate, composite woven glass fiber cone woofers provide amazing dynamics with good damping and modal control to deliver tight and punchy mid and low-frequency response that’s perfect for casual and professional playback environments. The glass fiber structure is heat-resistant and features a high strength-to-weight ratio, ensuring the monitors are highly adaptable and sonically accurate.

    Additionally, high-frequency reproduction emanates from a carefully designed woven-textile dome tweeter with a neodymium motor, which accurately extends the frequency range up to 40 kHz in the KRK Kreate 8 and 5 options, and up to 33 kHz in the 3 option, for a smoother, more detailed sound profile. The textile dome tweeters are used to create a smooth accurate response.

    Furthermore, the system-tuning level control and low-frequency and high-frequency shelving filters allow for easy adjustment in various acoustic conditions. Hybrid Class D and Class AB amplification delivers power and headroom with excellent dynamics reproduction. The high-performance transducers are optimized for improved response and accuracy. For maximum transient response and dynamics reproduction, the amplifiers drive the transducers efficiently at reduced operating temperatures to ensure audio integrity during long work sessions.

    The monitors are launching in KRK’s signature black/yellow and latte/black color scheme, with the Kreate 3 models sold as a pair and the Kreate 5 and Kreate 8 options priced individually. The series also continues KRK’s visual branding evolution, with packaging and stylization that closely align with other monitors from the brand’s product portfolio.

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  • Research reveals secret behind scarless healing in the mouth

    Research reveals secret behind scarless healing in the mouth

    Your mouth is a magician. Bite the inside of your cheek, and the wound may vanish without a trace in a couple of days. A preclinical study co-led by Cedars-Sinai, Stanford Medicine and the University of California, San Francisco (UCSF), has discovered one secret of this disappearing act. The findings, if confirmed in humans, could one day lead to treatments that enable rapid, scarless recovery from skin wounds on other parts of the body.

    The study was published in the peer-reviewed journal Science Translational Medicine.

    Our research began with two questions: Why does your mouth heal so much better than your skin? And if we figure that out, can we use that information therapeutically?”


    Ophir Klein MD, PhD, executive vice dean of Children’s Health at Cedars-Sinai, executive director of Cedars-Sinai Guerin Children’s, the David and Meredith Kaplan Distinguished Chair in Children’s Health and co-corresponding author of the study

    The need for therapies is clear. Wounds to the lining of the mouth typically disappear in one to three days. But skin wounds may take nearly three times as long to heal and can leave unsightly scars.

    “Unfortunately, current treatments do not adequately resolve or prevent scarring because we do not fully understand the mechanism,” Klein said. “Our research helps fill in that knowledge gap.”

    In the study, investigators analyzed tissue samples from the lining of the mouth, known as the oral mucosa, and the facial skin of laboratory mice. In the oral mucosa, they found a signaling pathway between cells, involving a protein called GAS6 and an enzyme called AXL, which blocks a different cellular pathway, known as FAK, that promotes scarring.

    When the investigators inhibited the AXL enzyme in the laboratory mice, the oral mucosa wounds’ healing worsened, making them more like skin wounds. When AXL was stimulated in the skin wounds, they healed much like oral mucosa wounds, regenerating tissue more efficiently.

    “This data shows that the GAS6-AXL pathway is potentially important for scarless healing in the mouth and that manipulating it may help reduce skin scars as well,” Klein said.

    The next steps are to further determine how these preclinical findings apply to humans and to develop therapies to improve healing of skin wounds, according to Michael Longaker, MD, the Dean P. and Louise Mitchell Professor in the School of Medicine at Stanford University, and the study’s co-corresponding author.

    “Further clinical studies should be performed to assess the nature of the relationship between AXL and scarring in humans,” Longaker said.

    Source:

    Cedars-Sinai Medical Center

    Journal reference:

    Griffin, M. F., et al. (2025) Growth arrest specific–6 and angiotoxin receptor–like signaling drive oral regenerative wound repair. Science Translational Medicine. doi.org/10.1126/scitranslmed.adk2101.

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  • Transport connectivity paves brighter way for more trade among SCO members-Xinhua

    TIANJIN, July 3 (Xinhua) — Since late June, 29 drivers from Kazakhstan have been participating in immersive training sessions in north China’s Tianjin Municipality to master light-rail driving skills.

    Held by Tianjin Rail Transit, the three-month program will provide technical solutions for equipment system installation and commissioning, extreme weather response, equipment procurement, and renovation for a light-rail line in Astana, the capital of Kazakhstan.

    Rather than copying China’s experience, the team studied Astana’s local conditions and customized training programs and materials to meet its specific needs, said Wang Qingyong, a consulting manager with Tianjin Rail Transit.

    “To enhance connectivity, we not only need to deepen infrastructure links but also promote closer ties between the peoples,” said Wu Bingjun, chairman of the Tianjin company.

    Transportation has always been a leading area for cooperation among the Shanghai Cooperation Organization (SCO) countries. From Tuesday to Wednesday, the Senior Officials’ Meeting of the Global Sustainable Transport Forum and the 12th meeting of the SCO Ministers of Transport were held in Tianjin, where officials from different countries provided new insights into promoting regional transport connectivity.

    Sohail Khan, deputy secretary-general of the SCO, said at the forum that “we aim to develop a sustainable, efficient transportation system that delivers high-quality services while incorporating cutting-edge technologies contributed by all participating countries, including China.”

    Multiple transportation corridors have opened shipping channels and added trade routes for SCO countries, serving as new engines for industrial and economic development.

    On June 30, Beijing’s first cross-Caspian Sea China-Europe freight service to Baku, the capital of Azerbaijan, was launched. The route employs a rail-sea-rail multimodal transport system, covering more than 8,000 km and reducing the transit time from approximately 50 days to around 15.

    “The launch of this train has established a more convenient and efficient international logistics channel, and will significantly promote trade between China and other countries and regions like Azerbaijan,” said Wang Dong with China Railway Beijing Group’s logistics center.

    Last year, Azerbaijan received over 350 trains from Chinese cities as part of the China-Europe freight train service. This service continuously drives the upgrade and expansion of trade corridors, said Fariz Aliyev, head of the transport policy department at Azerbaijan’s Ministry of Digital Development and Transport.

    The China-Europe Railway Express exemplifies the growing transport connectivity between China and the SCO member states. According to the Ministry of Transport, in 2024, a total of 19,000 China Railway Express trains passed through SCO countries and regions, representing a 10.7 percent year-on-year increase, as the regional connectivity network becomes more intertwined.

    Li Yang, China’s vice minister of transport, said that China will continue to engage with the world and keep up with the times, promoting global transport cooperation, offering new opportunities through its development, and continuously fostering global transport collaboration based on mutual consultation, joint construction, and shared benefits.

    In 2024, trade between China and SCO member states, observers and dialogue partners reached a record 890 billion U.S. dollars, and the total stock of various investments has exceeded 140 billion dollars, with the value of newly signed engineering contracts surpassing 1 trillion dollars and a cumulative turnover of over 680 billion dollars.

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  • Punjab CM expresses Govt's resolve to make province plastic-free – RADIO PAKISTAN

    1. Punjab CM expresses Govt’s resolve to make province plastic-free  RADIO PAKISTAN
    2. ‘Green credit’ scheme for recycling plastic bottles launched in Lahore  The Express Tribune
    3. Punjab launches ‘Plastic-Free Punjab Pledge’ campaign  nation.com.pk
    4. Breaking the plastic habit  Pakistan Today
    5. CM Maryam launches Pakistan’s first incentive-based environmental programme  Associated Press of Pakistan

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