Kathryn Bigelow and Netflix have debuted A House of Dynamite at the Venice Film Festival this evening, marking the Oscar-winning filmmaker’s first feature in eight years.
The nuclear thriller opens as an unattributed missile is launched at the United States. As a result, a race begins to determine who is responsible and how to respond.
The movie stars Idris Elba, Rebecca Ferguson, Gabe Basso, Jared Harris, Tracy Letts, Anthony Ramos, Moses Ingram, Jonah Hauer-King, with Greta Lee and Jason Clarke. Script comes from Noah Oppenheim.
The critical reaction so far has been overwhelmingly positive.
Deadline’s Pete Hammond wrote: “[Kathryn Bigelow] hasn’t lost her mojo if this nail biting thriller is any indication. Let’s just hope the world takes notice because this explosive story is scary in many ways, but mostly because it is so completely plausible in the powder keg of a planet we currently exist in.”
The Guardian gives the film 5/5 stars, describing it as “a terrifying, white-knuckle comeback” and and “immaculately constructed nightmare procedural that ticks down the minutes from an atomic bomb’s launch to its detonation.”
In a 4/5 star review, the BBC said The Hurt Locker director builds “excruciating tension”, saying “It’s a characteristically authentic, riveting and chilling drama” from the filmmaker.
The Independent also gave it a strong 4/5 writeup, calling it “The most entertaining movie about mass destruction since Dr Strangelove”: “This is a white knuckle ride of a movie in which the tension is ratcheted up to near breaking point early on, and then simply keeps on rising. German composer Volker Bertelmann’s ominous score, heavy on the strident strings, puts viewers on edge even more.”
Roger Ebert.com was also a fan, noting: “Bigelow’s ability to take a series of hypotheticals and render them into narrative actuality has never been more pinpoint accurate or merciless.”
Another 4/5 review came from the UK’s Daily Telegraph, which called it a “hair-raising thriller” and “a razor-sharp Armageddon procedural”.
GQ also had praise for the film, describing it as “brilliantly constructed and gripping as hell”, but mused on its Oscar chances: “The film may prove too limited emotionally for Oscars voters – though it is so brilliantly stitched together by editor Kirk Baxter that you struggle to imagine anything else taking home that particular award. But as Netflix movies go, this is pretty much as good as it gets – the last thing you’ll do during this two-hour block is look at your phone. And that is a step in the right direction, at least.”
Time Out is yet another 4/5 star review, saying of Idris Elba: “Elba is solid in his second POTUS role of the year, after the immeasurably wackier Heads of State, although the final stretch lacks the piano-wire tautness of what came before.”
Producers are Greg Shapiro, Bigelow, and Oppenheim. EPs are Brian Bell and Sarah Bremner. The project marks Bigelow’s first movie since the 2017 thriller Detroit.
A little girl’s headaches turned out to be a rare, inoperable brain tumor.
Rosie Hassall, five, started complaining of a pain in her forehead in November 2024.
Initially her parents – Charlotte, 36, and Stefan, 37, thought it was just a headache and gave her Calpol.
They noticed her left eye appeared delayed and booked an optician appointment – which found nothing wrong – and a doctors appointment.
Doctors didn’t know what was wrong before an MRI revealed a tumor in her brain.
A biopsy in January 2025 confirmed Rosie had pediatric bithalamic glioma containing a rare genetic abnormality – an aggressive and inoperable tumor due to its location, with a prognosis of nine to twelve months.
But after five rounds of chemotherapy Rosie has returned to school.
Mom Charlotte, an NHS worker, from Cheshire, said: “Rosie started complaining about pain in her forehead.
“At first, we thought it was just a headache, so we gave her Calpol, but the pain began to come more frequently.
(Brain Tumour Research via SWNS)
By Talker
“I couldn’t believe it. After just one scan and no blood tests, I thought they must be wrong. As professional and kind as they were, the reality of the situation and what they were telling me were difficult to grasp.
“We didn’t think Rosie would be able to attend her school sports day in July, but she did, and she smashed it.
“She’s now returning to school for short sessions and has started her fifth round of chemo.
“She still has tough days, but she’s determined to carry on doing what she loves. She amazes us every single day.”
After an optician and doctors appointment found nothing wrong, Rosie became run down and was given antibiotics and diagnosed with an infection.
The family got a second opinion for her eye and a doctor confirmed she had a squint and referred them to ophthalmology at the Leighton Hospital in Crew – but they couldn’t pinpoint what was wrong.
The family were referred to pediatrics following a trip to out-of-hours care.
Rosie went for an MRI and on December 22 the family had a call and were told Rosie’s brain was compressed and she had a 6m tumor.
She had a biopsy on Dec. 27 to determine the type of tumor, and was diagnosed in the January.
Charlotte said: “I think, in that moment, I was still in denial. Apart from the pain, Rosie was just a normal little girl.
“When the pain wasn’t there, she was herself, full of attitude and life.”
On February 26, Rosie started radiotherapy alongside oral chemotherapy at The Christie Hospital in Manchester and had six weeks of it before starting chemotherapy.
She is now on her fifth cycle but a recent MRI scan, in June, showed the tumor was stable.
(Brain Tumour Research via SWNS)
By Talker
Charlotte said: “After everything she’d been through, I was deflated when they said the tumor hadn’t shrunk.
“However, stable was still a win, and she looked so much better.
“Her balance had improved, and her energy was back. You want more positive news, of course. You hope for a miracle. But I’m learning to celebrate the small victories.
“She’s still our little firecracker – determined, smiling and full of fight. We couldn’t be prouder of her.”
Rosie’s brother, Charlie, eight, was recently diagnosed with a chronic tic, which doctors believe is linked to the stress of being separated from his parents during Rosie’s hospital stays.
Charlotte said: “It’s not just the child with cancer who’s affected, it’s the whole family.
“Charlie just wanted time with us, and thankfully we’ve had that this summer. Emotionally, it’s hard to explain what this journey is like.
“Some days, I feel strong. Other days, I’m barely holding it together.
“Rosie keeps us going because her positivity is infectious. She looks so well that sometimes we forget just how serious this is. But we’re still living one day at a time.”
The Hassall family are continuing to raise awareness of brain tumors during Childhood Cancer Awareness Month in September with support from Brain Tumour Research.
They have support from Siobhain McDonagh MP – who donated to the fundraiser.
Charlotte said: “It means a lot to know that people in Parliament are listening. This is about Rosie, but it’s also about making sure other families do not have to go through what we’re facing.
“Research into brain tumors is so underfunded compared with other cancers, and more needs to be done by Government to support families and invest in research if we’re ever going to find a cure.”
Ashley McWilliams, community development manager at Brain Tumour Research, said: “Rosie’s strength and the courage of her family are extraordinary. Her story shows how devastating brain tumors are, striking children with their whole lives ahead of them. During Childhood Cancer Awareness Month, we’re reminded of the urgent need for more research to give families like Rosie’s real hope. No parent should have to hear that there are no treatment options left.”
Andrew T. Kuykendall, MD, lead investigator for the phase 3 VERIFY trial (NCT05210790), emphasizes the critical need for therapies that offer a sense of normalcy to individuals with polycythemia vera, elaborating on the unique challenges of living with polycythemia vera and examining the profound impact of rusfertide on these patients.
Early indications from the phase 2 REVIVE trial (NCT04057040), findings which served as a foundation for VERIFY, were overwhelmingly positive, with patients reporting they felt “better than they ever had; this was really something that changed their lives,” Kuykendall explains. This strong, meaningful feedback centered on improvements to their symptoms and their daily lives, allowing them to regain “a sense of independence and freedom that they didn’t have before or they thought they’d lost,” he adds.
Beyond the goal of curing polycythemia vera and targeting its underlying disease-driving mutations, there’s a growing recognition of the need to address what matters to patients on a daily basis. This agent and trial, Kuykendall notes, were unique in their focus on clinically relevant end points, aiming to determine if a better approach was possible. Core questions driving the research were: can blood counts be controlled? Can patients be freed up from the health care system? Is it possible to move away from the need for phlebotomies? Is it possible to make patients feel better on a daily basis? Phlebotomy, a deeply entrenched treatment paradigm, is common for patients often managed in the community, Kuykendall explains.
These objectives resonated deeply with patients and are precisely why the results, announced at the American Society of Clinical Oncology annual meeting, were deemed so exciting. The potential for rusfertide’s self-injection approach to really alter community physicians’ practice on a daily basis with some of these patients, he concludes, makes it a topic of great interest.
Rusfertide most recently received a breakthrough therapy designation from the FDA on August 25.1 It previously received an orphan drug designation and a fast track designation in 2020.2
Revisit part 1 of this interview, in which Kukendall speaks to rusfertide’s potential as a sustainable management strategy for polycythemia vera, and part 2, in which he first alludes to the need for therapies to treat this myeloproliferative neoplasm to offer a sense of normalcy.
References
Pelosci A. Rusfertide earns FDA BTD for erythrocytosis in polycythemia vera. Cancer Network®. August 25, 2025. Accessed September 2, 2025. https://www.cancernetwork.com/view/rusfertide-earns-fda-btd-for-erythrocytosis-in-polycythemia-vera
Rusfertide received breakthrough therapy designation for treatment of erythrocytosis in patients with polycythemia vera. The National Law Review. August 25, 2025. Accessed September 2, 2025. https://natlawreview.com/press-releases/rusfertide-receives-breakthrough-therapy-designation-treatment
The American College of Cardiology (ACC) has issued Concise Clinical Guidance (CCG) recommending vaccines to protect adults with heart disease from respiratory illnesses, including respiratory syncytial virus (RSV), influenza, and COVID-19.1,2
Image credit: guerrieroale | stock.adobe.com
“Vaccination against communicable respiratory diseases and other serious diseases is critical for people with heart disease, but barriers exist to ensuring people are educated on which vaccines to get, how often to get them, and why they are important,” Paul Heidenreich, MD, FACC, chair of the CCG writing committee, said in a news release. “With this document, we want to encourage clinicians to have these conversations and help their patients manage vaccination as part of a standard prevention and treatment plan.”2
Individuals with heart disease face an increased risk of contracting respiratory viruses and experiencing severe outcomes, including hospitalization and death. Although previous studies have demonstrated that vaccines are effective at reducing these risks, a recent study found that only 30% of health care providers, including primary care physicians, are checking their patients’ vaccination status during appointments.1,2
RSV and Heart Disease
Older adults and individuals with chronic medical conditions face a higher risk of severe RSV and related cardiovascular complications. Those most vulnerable to RSV include all adults 75 years and older, adults aged 50 to 74 with specific risk factors, and individuals with weakened immune systems or those living in nursing homes. Individuals with chronic medical conditions like lung disease, heart failure, coronary artery disease, kidney disorders, obesity, and certain neurologic conditions are also at an increased risk.3
According to the American Heart Association, nearly 150,000 adults aged 60 years and older are hospitalized annually in the US due to serious cases of RSV. The virus is known to have significant effects on heart health, including damaging heart muscle, causing inadequate blood supply to the heart, known as ischemia, and increasing the risk of irregular heartbeat, or atrial fibrillation. RSV can also worsen existing heart conditions, such as arrhythmias and heart failure, and is linked to a higher risk of heart attack or stroke, particularly within the first 3 days of infection.3
Vaccine Recommendations for Respiratory Illness and Heart Disease
The guidance from the ACC and American Heart Association primarily focuses on respiratory vaccines but also includes information on the herpes zoster vaccine, as previous evidence suggests it may provide cardiovascular benefits. The document outlines strategies to improve vaccination rates and address patient hesitancy and barriers to access.1,2
RSV
The RSV vaccine is recommended for adults aged 75 years or older and those aged 50 through 74 years with heart disease, as it protects against lower respiratory disease that could lead to hospitalization or death. The current guidelines advise a single dose of 1 of the 3 approved RSV vaccines—RSVPreF3 (Arexvy; GSK), RSVpreF (Abrysvo; Pfizer), or mRNA-1345 (mRESVIA; Moderna)—for all adults 75 years and older, along with individuals aged 60 to 74 years who are at increased risk of severe illness, instead of an annual vaccination.1,2
Influenza
An annual flu vaccination is recommended for all adults, based on the CDC and several cardiovascular societies, confirming its ability to reduce cardiovascular and all-cause mortality and morbidity. However, nasal versions of the vaccine are not suggested for use in patients 50 years and older.1,2
Evidence for this recommendation is supported by 6 randomized controlled trials and other studies, including a total of 6734 individuals. In the meta-analysis, researchers found that over a 7.9-month follow-up period, vaccine recipients had a 36% lower risk of major adverse cardiovascular events compared to those who received a placebo or no vaccine.1
Pneumococcal
The pneumococcal vaccine is recommended as a 1-time dose for adults aged 19 or older with heart disease to protect them from pneumonia, bacteremia, meningitis, and their associated risks of hospitalization and death. Following CDC recommendations, the guidance advises a single dose of either PCV20 or PCV21, or a combination of PCV15 followed by PPSV23, depending on the individual’s prior vaccination history.1,2
COVID-19
All adults with heart disease were recommended to receive the seasonal COVID-19 vaccine for the fall 2024 to 2025 season. However, the guidance noted that future COVID-19 vaccination recommendations for all adults may need to be reevaluated if the virus’s severity and prevalence continue to decrease. Despite this, it is likely that vaccination will remain beneficial for individuals with heart disease due to their increased risk of infection, severe illness, heart attack, COVID-19-induced pericarditis or myocarditis, COVID-19-induced stroke and atrial fibrillation, long COVID symptoms, and death.1,2
Shingles
Adults aged 50 years and older are recommended to receive 2 doses of the shingles vaccine to protect against stroke and heart attack during infection, as multiple observational studies have found that patients vaccinated for shingles experience a reduction in cardiovascular events. Additional randomized data also shows that the vaccine is as effective, or more effective, for patients with coronary artery disease compared to those with other chronic conditions.1,2
This document released by the ACC and American Heart Association suggests that discussing vaccination during cardiology appointments could be essential to integrate immunizations into a cardiovascular care plan.1,2
REFERENCES
1.A. Heidenreich, P, Bhatt, A, Nazir, N. et al. 2025 Concise Clinical Guidance: An ACC Expert Consensus Statement on Adult Immunizations as Part of Cardiovascular Care: A Report of the American College of Cardiology Solution Set Oversight Committee. JACC. null2025, 0 (0) .https://doi.org/10.1016/j.jacc.2025.07.003
2. The American College of Cardiology issues vaccine guidance for adults with heart disease. EurekAlert! News release. August 26, 2025. Accessed September 2, 2025. https://www.eurekalert.org/news-releases/1095588
3. RSV and Heart Health. American Heart Association. News release. Updated July 30, 2025. Accessed September 2, 2025. https://www.heart.org/en/health-topics/rsv
Some of your most interesting work comes when you feel like you’re skating on thin ice. On Splitsville, director Michael Angelo Covino and I leaned into the imperfections that come with shooting on film with older lenses and doing fewer takes. Riding that razor’s edge of getting the shot or not getting it — we live for that.
Mike is drawn to French cinema made during the 1970s, when the introduction of sync-sound reflex cameras meant you could run out with a battery and a small crew and just make something. We wanted Splitsville to honor that spirit; we worked with the mindset that we would strive to create something special without bogging it down with too many tools or people. We wanted the look to come across as intentional yet raw.
Following Ashley’s (Adria Arjona, center right) desire to divorce Carey (Kyle Marvin, center left), the couple and their friends, Paul (Covino, left) and Julie (Dakota Johnson, right), become entangled in a relationship dynamic with bizarre complications..
Mike understands how to highlight the absurdity of the human experience, and to that end, Splitsville moves from moments of minimalism and simplicity to extreme maximalism. We sought to constantly upend our relationship with the audience so they’d never be completely comfortable with the story we’re telling. The extended fight scene, which places the viewer right inside a brawl between Carey (Kyle Marvin) and Paul (Mike) after the former tells the latter he has slept with his wife, Julie (Dakota Johnson), falls firmly on the maximal side of this tonal spectrum.
Broken Home: Choosing the Fight Scene’s Location
For our fight-scene location, we chose a modernist lake house that best represented the type of second home we thought Paul’s character would have — something beautiful that felt connected to the water and nature, but still felt like a bold, modern statement of wealth and abundance. We then discussed what within the environment might be possible to break, and which spaces would be most fun to move through. We considered how the scene could start out simply as a moment of believable dialogue; then move into a wrestling match; and then have it devolve into a fight for the characters’ lives that would include breaking pottery and glasses, smashing tables, bodies being thrown down stairs, a fish tank blowing up, and finally, the characters crashing through a window into a swimming pool, all of which was written specifically in the script.
Paul turns a household item into a deadly weapon during a frenetic brawl with Carey when the former learns that the latter has slept with his wife.
Our production designer, Stephen Phelps, then helped build furniture pieces and windows for our actors to break. Kyle and Mike worked with stunt coordinator Tyler Hall on the scene every night after prep. At first, their extreme devotion boggled my mind, but it was clear they understood that this early scene would set the tone for the rest of the film.
Doubling Down on No Stunt Doubles
Kyle and Mike didn’t have stunt doubles for any part of the sequence. This was a point of pride for them. Early on, I told them the only way the scene would work would be with doubles, and that I didn’t think they would go at each other hard enough, but subconsciously, I think I might have been challenging them! At times, it felt like the three of us were all daring each other to grab the electric fence. I told them they’d have to commit 100 percent or it wouldn’t work, and to their credit, they did it. It’s also true that if your actors can perform something like this themselves, the results look better because you’re not hiding physical actions either with the camera or in the edit. I always push to do things practically even if it means rethinking how we shoot a scene, and here, we leaned into what’s happening in the moment onscreen.
On location, Newport-Berra, confers with Covino and Marvin before shooting portions of the film’s fight scene, which the actors performed entirely without the use of stunt doubles.
Camera Techniques and Oners
We aimed to approach every moment within the sequence as one shot and managed to achieve this in capturing the portion of the fight that takes place in the downstairs area of the house. For the first part of this shot, our Steadicam operator, Andre Perron, rested the Steadicam on an apple box so the shot would feel more locked off; at this point, the shot has a feeling of tension, but it’s also humorous. From there, the confrontation between Carey and Paul slowly escalates. Once the fight is fully underway, the two men fly into the study; at that moment, Andre lifted the Steadicam off the apple box and moved with them into this new room. Following this portion of the fight, Carey and Paul end up back in the living room, then move into the kitchen, then onto the stairwell, with the action in each room covered via the same Steadicam move.
Also Read: Adam Newport-Berra on Crafting “The Oner” for The Studio
I love oners; if anything, my work over the last couple of years has shown that shooting them is my dream scenario. But because Kyle and Mike performed their own stunts, and because Splitsville is a comedy about humanity — not an action movie — I also felt that some additional coverage would help the scene, even if it was just one punctuated move that sells the impression of a hit landing harder or a line landing funnier. So, we peppered in these little moments throughout. We shot a reverse on Paul for the beginning of the scene, but chose to remain wide, to keep our distance. This allows the viewer to observe that Paul is reacting, but not completely read into how he feels. We also captured some more extreme angles of the beginning of the wrestling — with one camera on the floor when the characters topple to the ground, to help sell the impact and signal a turning point in the fight; and a top shot of some of their wrestling maneuvers, to help better show their faces and play up the comedy of their lines. For the upstairs portion of the shoot, we added an underwater shot in the bathtub, to reveal Carey’s face as Paul tries to drown him in the tub. We also added close ups here and there for reactions, dialogue, or reveals, like when we see that Carey is missing his eyebrows.
The filmmakers prepare to shoot a stretch of the fight’s action that takes Paul and Carey outside after they crash through an upstairs window of Paul’s house.
Choosing — and Shattering — Glass
For the majority of the fight sequence, we used a Panavision Ultra Speed “Z” MKII series 24mm prime lens. (This lens, paired with Arri’s Arricam LT, our main camera, was occasionally exchanged with other glass in Panavision’s Ultra Speed and “Z” series.) The 24mm felt most natural and honest for the material — it’s wide but not distorted, the camera moves feel dynamic, and it proved versatile in finding wide or tight frames in the sequence seamlessly.
Our real set pieces — where things really got challenging — came when the fight moves upstairs. During this part, Carey and Paul move into Paul’s son’s room and Paul ends up breaking his son’s massive fish tank by throwing a bowling ball at it. We needed a tank that would be big enough to make an impression on the viewer, but every gallon of water weighs 8 pounds, and our tank held about 60 gallons that would eventually be spilled out. The house we shot in was brand new, and the owners were, understandably, worried. So, our art department designed and built a reservoir that looked like the floor of the room but was covered by carpet; the reservoir weighed about 3,000 pounds and held about 250 gallons, which allowed us to catch all of that water to prevent it from seeping into the floorboards.
On top of all that, we only had one take to shoot the upstairs material. We had special effects supervisor David Loveday remotely controlling a detonator that broke the fish-tank glass, which had to be perfectly timed with the throwing of the bowling ball. We wanted to capture this moment in camera, and although we did shoot coverage, we took care to avoid cheap cutaways. We needed to see the aftermath of the broken glass and water everywhere with the camera rolling. This was one of the few times we decided to have two cameras rolling to make sure we got the shot. All of this was terrifying, but in the end, we pulled it off.
Out of Window, Under Water
Another challenging moment to capture is when Carey and Paul break through the upstairs-hallway window and land in the pool outside. The production built a set that replicated the end of the hallway next to the actual window, and we stitched that together with shots in the hallway. We have a POV shot of Carey and Paul rushing through the window and a profile shot, for which we blocked the house with our set piece to capture them as they crash through the window and land on a mat off camera. We used a 35mm “Z” series lens in this shot to compress the background of the environment and ensure the set felt congruent with the geography of the location.
The jump for Mike and Kyle was about 15 feet down, and Mike tackling Kyle through breakaway glass had them cut up and bloodied. Shooting on film, we couldn’t watch anything back; we had to just pray the film would come back. We also shot the break through the window at high speed on an Arri 435 Xtreme, which made things even riskier. We did one take, which went well enough. After some discussion, we decided there was no reason to risk doing another one, so we moved on to our aquatic work to capture the moments following the characters’ landing in the pool and their continuation of the fight underwater.
We spent a morning shooting Mike and Kyle beating the hell out of each other underwater, using the 435 Xtreme, which was fitted into a HydroFlex RemoteAquaCam Mk5 housing.
Shooting underwater — especially on film — is difficult, because you don’t see what you get until you develop the film. Focus marks change with the flat-front attachment, so our 1st AC, Nico Marion, had to be very calculated in his focus-pulling efforts. On a bigger film, one would probably have another unit prepped to do this, but on our more modest budget, this was just an hour of an otherwise jam-packed day, so we really couldn’t afford to miss the shot. We just dove right in, and everyone nailed it.
I would never pressure an actor to do something they aren’t comfortable with, but a sequence like this one is always better when it’s practical and done as much with the actors as possible. It takes a lot of faith. If the actors are going to risk their safety, they must trust that I can capture that performance and deliver it in a way that makes it all worth it. It goes to show how important the relationships between cinematographers and actors are, and how much we rely on one another for success.
An international research team led by MDI Biological Laboratory President Hermann Haller, M.D. and postdoctoral researcher Yannic Becker, Ph.D. has discovered that a little-known molecule, heparanase 2 (Hpa2), plays a critical role in maintaining blood vessels’ integrity.
Malfunctions in the vasculature are increasingly seen as an underlying driver of a wide array of diseases.
The findings were published in the peer-reviewed journal, Arteriosclerosis, Thrombosis, and Vascular Biology. They suggest that Hpa2, which occurs naturally in vertebrates and other animals, could be useful in new therapies for vision and chronic kidney diseases, cardiovascular disease and cancer.
The vasculature’s interior is lined by the endothelium, a single layer of cells that control what passes in and out of the blood stream. Its permeability and structure depend on heparan sulfate proteoglycans – sugar-based molecules that anchor signaling proteins such as vascular endothelial growth factor (VEGF) to the cells.
The researchers found that Hpa2, until now poorly understood, also binds strongly to heparan sulfate at the same anchor site, and can block growth-factor signaling.
VEGF is essential for normal tissue growth and repair. But when overactive it can cause leaky blood vessels, contributing to diseases such as diabetic retinopathy and macular degeneration in the eye, and protein loss in the kidney (proteinuria). It can also aid cancer cells’ ability to highjack the vasculature for their own sustenance.
Working with zebrafish, mouse kidneys and human endothelial cell cultures, the research team showed that when Hpa2 is absent, vessels lose their structural integrity and become abnormally leaky. Introducing manufactured Hpa2 reversed that fragility, restoring normal vascular function.
Usually most of our blood vessels are pretty tight, but we saw that if we take out heparanase 2, we have an increased flux of molecules and water into the interstitium. This discovery identifies Hpa2 as an essential safeguard for the blood vessel wall.”
Yannic Becker, Ph.D., study’s first author
Key findings
Hpa2 is conserved across vertebrates and circulates in the bloodstream.
Hpa2 competes with VEGF and other growth factors for binding to endothelial cells, dampening overactive growth-factor signaling.
Loss of Hpa2 increases vascular permeability and disrupts endothelial structure in zebrafish.
Application of recombinant Hpa2 blocks VEGF-induced permeability and restores vascular function in mouse kidneys.
“Hpa2 shows promising pharmaceutical potential,” said Haller, the article’s senior author. “Current therapies for vascular disease often focus on blocking growth factor signaling, but Hpa2 may offer a more natural mechanism to restore balance without adverse side effects.”
Funding
This research was supported by the German Research Foundation (DFG), the Scott MacKenzie Foundation and the U.S. National Institutes of Health Institutional Development Award (IDeA) program (P20GM103423 and P20GM104318).
Source:
MDI Biological Laboratory
Journal reference:
Becker, Y., et al. (2025). Heparanase 2 Modulates Vascular Permeability via Heparan Sulfate–Dependent Growth Factor Signaling. Arteriosclerosis Thrombosis and Vascular Biology. doi.org/10.1161/atvbaha.125.323060
Part of the magic of portraiture is how it renders so much of the human experience accessible to us, things we might never see otherwise. This has been very much on Black artist Amy Sherald’s mind. When I spoke to her in advance of the debut of her exhibition American Sublime, she told me that Black representation was foundational to her practice: “I developed this idea that, when I look at art history, for the most part I don’t see portraits of people that look like me. So it started there.”
That exhibition’s curator, Sarah Roberts, also spoke about Sherald’s passion for representing the LGBTQ+ community: “Amy has thought a lot about her role as an artist and the need for representation, and she has long been a champion of LGBTQ+ rights. This work is thinking about who gets depicted as being American.”
It was no surprise, then, that Sherald would have a very strong reaction when the Smithsonian attempted to censor Trans Forming Liberty, a portrait that she made of the Black trans woman Arewà Basit, out of American Sublime in advance of its arrival there. As Sherald told the New Yorker: “Trans Forming Liberty challenges who we allow to embody our national symbols – and who we erase. It demands a fuller vision of freedom, one that includes the dignity of all bodies, all identities … This portrait is a confrontation with that truth.”
More than just censoring Trans Forming Liberty from American Sublime to appease the Trump administration, the Smithsonian added insult to injury when it suggested that Sherald replace her artwork with a video of cisgender people debating whether or not trans people deserved inclusion in American society. The artist lost no time in responding to these actions by pulling her show from the Smithsonian.
Amy Sherald’s Trans Forming Liberty on display. Photograph: Matthew Millman/Matthew Millman Photography
The skirmish over Sherald’s piece highlights the importance of trans representation in the artwork that hangs in our museums and galleries – a 2022 Pew poll found that less than half of Americans believed that they had ever met a trans person, meaning that seeing representation such as Sherald’s might add a dose of empathy and connection to a community that is in need of compassion from cisgender Americans. At the time when the trans community is being demonized with the fervor of a moral panic, it is no exaggeration to say that such encounters are transformational.
The Bay Area trans artist Éamon McGivern has made trans portraiture central to his artistic practice. His collection, Still Lives, a Trans Portrait Project, was recently shown in the Tenderloin Museum in San Francisco as a tribute to his connection with the trans community.
McGivern was appalled, although not surprised, at the idea that trans people are now being erased from museums with strong ties to the federal government. “We’re at a point where you can’t show a picture of a trans person at a federally funded institution and that’s bad, that’s fascism,” he said. “If cis artists are being asked to edit, what does that mean for queer and trans people?
He awarded Sherald points for understanding the importance of representing trans people in her art. “Since Sherald’s an artist of color, I’m sure she has to think these issues through more than the average person. The fact that she cares enough about trans people enough to include them in her body of work means that she gets it.”
Éamon McGivern – Ray and Sathya, 2022. Photograph: Éamon McGivern
While showing his work, McGivern has frequently seen cisgender people have to wrestle with their preconceived stereotypes around who trans people actually are. “The response I get from cisgender people is that they didn’t know trans people looked like that,” he said. “And that really opened my eyes, where I’m like: ‘Wow, people have such a narrow view.’ That we can just be normal people living normal lives.”
McGivern sees trans portraiture as far more than just a way of acquainting cisgender viewers with the trans experience. He shared that his series of portraits of trans people came out of his own experience of isolation after undergoing gender-affirming surgery: “I lost my housing during recovery from top surgery,” he said. “I looked around, and I realized that I didn’t have any capital T trans people in my life. I needed trans people around me who got it.”
Painting portraits of trans people became a lifeline at the very time he needed it: his art helped him build exactly the community he was in search of. “I started reaching out to people who I thought were cool hot trans people. I wanted to show portraits of people who were not alone and in community. Reaching out to people who seemed to have that in their lives, showing that in my art was subconsciously a way of getting that for myself.”
Like McGivern, Atlanta artist Sean La’Mont began creating trans portraits as a way of being in community. She recalled that in 1997 she began to frequent drag clubs and was astonished by the beauty of the trans women who danced there. “I thought: ‘Wow, these are amazing people!’ and it was that curiosity that started me drawing them.”
Artwork by Sean La’Mont. Photograph: Courtesy of the artist
La’Mont’s years of drawing the trans community have brought her into contact with some astonishing trans people, including surgeon Dr Marci Bowers, who is considered one of the top vaginoplasty surgeons in the world. La’Mont recalled that at a trans health symposium in Atlanta she got the chance to come face to face with a personal hero – and draw her portrait.
“I was invited to do a show with the Trans Symposium, and Bowers happened to be the guest speaker that year,” she recalled. “The event organizers asked me to draw her, and then they presented it to her at the event. She was so gracious about it. She’s been an idol, she’s pretty incredible.”
For La’Mont, it’s the love of her community that has kept her inspired to draw portraits of trans people for decades now, something she’s eager to share with the cisgender population. “Art reflects how people live and love, and some of the greatest pieces are the ones that show how we live and love. I see their reaction, it’s like: ‘Oh my God, that’s beautiful.’”
Physical therapy and rehabilitation tailored specifically for cats can make a significant difference in the wellbeing of these felines. Cats recovering from surgery, as well as those who have osteoarthritis, are overweight, or are healing from non-surgical injuries may see improved mobility, faster recovery, and an overall improved quality of life, according to Michael H. Jaffe, DVM, MS, CCRP, DACVS, an associate professor of small animal surgery at Mississippi State University College of Veterinary Medicine, who led a Fetch dvm360 Conference lecture on the topic this past weekend in Kansas City, Missouri.1
Other benefits of rehabilitation therapy include1:
Promoting early weight-bearing and return to function
Supporting weight loss
Improving proprioception and movement
Promoting tissue healing
Providing positive psychological effects
Increasing strength and endurance
Improving flexibility
Reducing pain, inflammation, and swelling
Offering a non-invasive approach
Carrying minimal risk of complications
Preventing compensatory injuries
Engaging owners in their pet’s care
“I always say that with surgery, we put the pieces together, but physical therapy and rehab gets the parts moving again. And I think there’s a lot of truth to that,” said Jaffe during his presentation.1
Massage therapy
Pet owners and practice owners who may not have specialized rehabilitation equipment can perform massage therapy on cats, explained Jaffe. This type of therapy promotes blood flow to the muscles, improves connective tissue strength and tendon elasticity, reduces some muscle spasms, and lowers stress and anxiety. According to Jaffe, massage therapy is also beneficial for breaking down adhesions.
“As far as lymphatic flow, that’s important, because any edema that may form in the tissue, or certainly distal to the tissue, can be mobilized pretty quickly in terms of promoting that blood flow and improving the lymphatics to help drain some of that edema that’s forming in the interstitial space,” he added.
In patients that have undergone surgery, Jaffe explained this therapy should be started within the first 24 to 48 hours after the procedure. Some patients may even receive massage therapy prior to undergoing more intensive rehabilitation protocols, noted Jaffe. Additionally, clients can be taught to perform massage therapy on their pets at home.
When it comes to the massage technique, Jaffe said he likes to isolate one joint at a time rather than doing a bicycle movement or the “accordion movement where you grab the foot and you pull the leg forward and back and forward and back.
“I really don’t like to work on more than one joint at a time because with activities like the bicycle motion or the accordion motion, you are working all of the joints at one time, and not every joint is going to be capable of the same mobility as others,” Jaffe emphasized. “To try to prevent injuries, I really think it’s best to work each individual joint by itself: hold the stretch for just a second or 2 and then…release it so that we don’t injure the patient.”
Heat therapy
As Jaffe explained, hot compresses cause vasodilation, promoting blood flow to tissues and increasing their metabolic rate. Heat therapy also increases the release of histamines, bradykinins, and prostaglandins, which may help lower inflammation in the tissue that is being warmed.
“This does also have the benefit of improving flexibility of fibrous tissue and so [for] joint capsule that may be a little bit contracted, it’s going to loosen things up a little bit,” said Jaffe.
Patients with chronic diseases, such as osteoarthritis or back pain will benefit from this form of therapy. According to Jaffe, heat therapy also improves lymphatic flow and can help decrease swelling and edema in tissue. Jaffe suggests doing a warm compress beginning at approximately 24 or 48 to 72 hours after a surgical procedure.
“Initially, we’re going to use our cold compresses to try to reduce some of the pain and inflammation at the surgery site following surgery. We’ll certainly do cold compresses on our incision, but [for] the muscles that we’ve manipulated and have moved around and that have developed injuries, we’re going to want to do warm compresses on those to try to improve that blood flow and promote healing,” explained Jaffe.
“I often use [heat therapy] as part of our warm up prior to any massage or passive range of motion or other exercises,” said Jaffe. “I like to use it to help decrease some of the muscle tightness prior to when we do our stretches and help decrease any muscle spasms as we work our muscles and take them through range of motion.”
Jaffe warns against using heat therapy for tumors because the blood flow to the tissue could promote metastasis. Other contraindications include open wounds, patients with severe cardiac insufficiency, and acute inflammation—for which cold compresses should be used in the first 48 to 72 hours post surgery. Additionally, veterinary professionals and pet parents at home should be careful when using hot compresses in areas with decreased or absent sensation, as well as with making sure the temperature is not too hot that it can burn the pet.
Cold therapy
Unlike heat therapy, cold therapy causes vasoconstriction, decreasing edema formation and helping to lower inflammation and hematomas that may form from an acute injury, said Jaffe.
“A lot of times when we’re putting a pet through a fairly vigorous workout with our rehab protocols, we’re going to ice them down afterwards,” explained Jaffe. “We’re going to use our cold compresses to decrease any pain or muscle spasms or muscle injury that may have occurred during our rehab session.”
Ice packs can be used for cold therapy, but caution should be taken not to put the packs directly on the cat’s skin. Instead, the ice packs should be wrapped in a towel to prevent cold shock or injury to the patient’s skin. Each session, Jaffe explained, should last no longer than 10 to 15 minutes. However, sessions can be repeated approximately every 4 hours as needed.
References
Jaffe MH. Feline physical therapy and rehabilitation. Presented at: Fetch dvm360 Conference; August 25-26, 2025; Kansas City, Missouri.
We stroll past wheat, clover, and grass and see only the green half of the story. The other half – the roots – do the heavy lifting: anchoring plants, pulling up water and nutrients, and locking away carbon in the soil.
Yet because roots are hidden, scientists have spent decades using muddy, labor-intensive methods to guess their size and spread, often missing the finest, most active threads. According to a team of researchers at Aarhus University, that guesswork can finally stop.
A high-tech root census
“It’s a bit like studying marine ecosystems without ever being able to dive,” said senior author Henrik Brinch-Pedersen, a professor in the Department of Agroecology.
Until now, the standard approach was to carve out big blocks of soil, wash away the dirt, sort and dry what remained, and weigh the roots. It’s slow, destructive, and misses the fine roots that absorb nutrients and release carbon to the soil.
The new approach swaps spades for droplet digital PCR (ddPCR), a DNA technology that partitions a teaspoon of soil into tens of thousands of microscopic droplets. Each droplet then answers a yes/no question: Does it contain plant DNA with a specific genetic signature?
The team uses a marker called ITS2 – think of it as a barcode that differs among species – so a single run can reveal not just that roots are present, but whose roots they are. Crucially, it also shows how much underground biomass each species contributes.
“It’s a bit like giving the soil a DNA test,” Brinch-Pedersen said. “We can suddenly see the hidden distribution of species and biomass without digging up the whole field.”
Mapping roots with precision
Because ddPCR counts DNA molecules across thousands of droplets, it can quantify roots that would otherwise be pulverized or rinsed away.
That makes it possible to map root communities at high resolution in living fields, pastures, and mixed-species grasslands and to repeat measurements over time without disturbing the site.
The payoff spans several fronts. For climate research, it lets scientists measure how much carbon different crops actually push belowground – data that’s been frustratingly hard to pin down but is essential for credible climate accounting in agriculture.
For plant breeding, the digital DNA method creates a path to select varieties that invest more in roots without sacrificing grain or forage aboveground.
And for biodiversity science, the technology finally illuminates the underground dynamics in species mixes – who’s competing, who’s complementing – insights that were “almost impossible before,” Brinch-Pedersen noted.
Roots matter for the climate
We tend to picture wind turbines and EVs when we think of climate solutions, but roots are a vast, quiet carbon pump.
As plants photosynthesize, some of the captured carbon flows belowground into roots and the surrounding soil. Depending on the crop, soil type, and management, a fraction of that carbon can persist for decades or even centuries.
Farmers and policymakers talk about “soil carbon sequestration,” but without precise measurement tools it’s been hard to document gains in ways that stand up to scrutiny. A rapid, species-resolved root assay changes that equation.
DNA test in soil
In practice, researchers collect small soil cores, extract DNA, and run ddPCR with species-specific probes keyed to the ITS2 barcode. The number of positive droplets scales with root biomass for that species in that sample.
Because the test targets DNA directly in soil, it captures fine roots and root fragments as well as thicker roots that are tough to wash and weigh.
There are, however, limits. Close relatives can be tricky to tell apart when their barcodes are nearly identical – ryegrass and Italian ryegrass hybrids, for instance, can blur the signal.
And the method recognizes only what it’s trained to find. Researchers must validate a probe for each species, so expanding the “DNA library” is both the hurdle and the goal.
“For us, the most important thing is that we have shown it can be done,” Brinch-Pedersen said. “Our vision is to expand the library so we can measure many more species directly in soil samples.”
Rapid answers from soil
Speed is the other advantage. Traditional root studies hinge on days to weeks of field and lab work per site. The ddPCR method turns around results in hours, making it practical to scale from a few experimental plots to entire farms, seasons, and regions.
That opens the door to experiments that were previously unrealistic. Researchers can compare cover crops for their belowground carbon contributions across soil types.
They can track how drought shifts root allocation among species in a pasture. They can also screen hundreds of breeding lines for deeper, denser root systems.
Plants that work smarter
Brinch-Pedersen sees a straight line from measurement to design. If breeders can quantify underground investment as easily as they count kernels or measure protein, they can begin to select for crops that are not only high-yielding but also high-sequestering. These are plants that do more of the climate work for us.
The same logic applies to mixtures. With species-level root data, agronomists can compose plant communities that pack more carbon belowground while maintaining forage or grain output above.
The bigger picture is simple: half a plant lives out of sight, and that half shapes soil health, farm resilience, and the climate. With a “DNA test for dirt,” researchers can finally watch that hidden half at work – no shovels required.
The study is published in the journal Plant Physiology.
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