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  • Increased Heart Failure-, Cardiovascular-Related Mortality Common Among Patients With CKD

    Increased Heart Failure-, Cardiovascular-Related Mortality Common Among Patients With CKD

    Concerning demographic and geographic disparities are present among certain patients with chronic kidney disease (CKD) and acute renal failure with underlying cardiovascular disease, according to an abstract presented at the European Society of Cardiology (ESC) 2025 Congress.1 Additionally, another abstract demonstrated that heart failure mortality among patients with advanced CKD has risen significantly over the past 2 decades.2 Of note, both ESC Congress abstracts utilized data from the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research (CDC WONDER).1,2

    Image credit: Rasi | stock.adobe.com

    Kidney Disease and Cardiovascular Death

    The first abstract utilized the data to perform a retrospective analysis of cardiovascular disease-related deaths in US patients with CKD and acute renal failure from 1999 to 2020. The investigators utilized ICD codes I10-I64 for underlying cardiovascular-related causes, N18 for CKD, and N17. Additionally, age-adjusted mortality rates (AAMRs) and annual percentage change (APC), along with 95% confidence intervals, were examined over time and across sex, racial and ethnic groups, and geographical regions using a joinpoint analysis.1

    Findings

    From 1999 to 2020, the investigators observed a total of 565,190 and 248,946 deaths that occurred in patients with CKD and acute renal failure, respectively. Interestingly, there was an overall decrease in mortality trends for both groups. The 85-years-and-older age group demonstrated a higher mortality rate in both groups, with a crude rate of about 173.99 in CKD and 81.31 in acute renal failure, respectively. In 2020, the analysis showed higher mortality trends among male patients in both kidney disease groups; however, males demonstrated higher deaths in CKD (AAMR: 20.22) compared with acute renal failure (AAMR: 8.48).1
    Further, the non-Hispanic White patients demonstrated the highest mortality trends in CKD (AAMR: 13.49; 95% Cl, 13.45–13.53) as well as in acute renal failure (AAMR: 6.49; 95% Cl, 6.46–6.52). In addition, the Midwest region exhibited the highest mortality trends in patients with CKD (APC: 0.02; 95% Cl, –1.50 to 1.67), whereas the Southern region showed increased mortality in patients with acute renal failure (APC: 2.19; 95% Cl, –1.27 to 6.18). Regarding state-specific trends, California had a high overall mortality rate from cardiovascular disease in both CKD and ARF. Conversely, Alaska was observed to have a lower mortality rate for both of the kidney diseases.1

    Advanced CKD and Heart Failure Mortality

    Similar to the previous abstract, this nationwide analysis also utilized data from the CDC WONDER database to calculate AAMR per 1 million individuals with advanced CKD aged 45 years and older who died from heart failure between 1999 and 2020. Heart failure-related deaths (ICD codes I11.0, I13.0, I13.2, I50.0, I50.1, and I50.9) and advanced CKD (N18.0, N18.4, N18.5) were identified from Multiple Causes of Death (MCD) records. Trends were analyzed across 10-year age groups, and joinpoint regression assessed AAPC in mortality rates.2

    Findings

    From 1999 to 2020, AAMR for heart failure with advanced CKD rose from about 27.99 to 87.88, with a steady increase after the early 2000s and a sharp surge following 2010, which peaked in 2020 (APCC: 5.3; 95% CI 4.1–6.6). Notably, male patients had higher AAMRs (71.5) compared with females (41.5). Crucially, racial disparities were evident, with non-Hispanic Black individuals having the highest AAMR (115.8), followed by American Indian or Alaskan Native (81.8), Hispanic or Latino (66.1), non-Hispanic Asian or Pacific Islander (49.1), and non-Hispanic White (45). Mortality rates were also slightly higher in metropolitan areas (53.9) than in nonmetropolitan areas (52.4).2

    Additionally, age-specific trends demonstrated significant increases across all groups, with the highest CMR observed in patients aged 65 and older (123.8). Regional variations in AAMR were notable, with the highest rates in the South (57.6), followed by the Midwest (52.9), West (51.1), and Northeast (49.26). Further, most deaths occurred in inpatient medical facilities (n = 68,875), with California reporting the highest number of cases (n = 16,887).2

    The findings from both abstracts show how having CKD—as well as other kidney diseases—is correlated with cardiovascular-related mortality. Depending on patients’ geographical location or demographics, there are notable disparities that present a higher incidence of death. The authors of both abstracts emphasized a need for optimized care, risk reduction, and policy reforms to address the disparities among underrepresented populations with kidney disease.1,2

    REFERENCES
    1. Abdul Q, Kakahel M, Khan I, et al. impact of advanced chronic kidney disease stages on heart failure mortality: a nationwide analysis using CDC WONDER. Presented at: European Society of Cardiology Congress; Madrid, Spain. August 29–September 1. https://esc365.escardio.org/ESC-Congress/abstract?text=chronic%20kidney%20disease&docType=All&days&page=1&vue=cards#:~:text=%C3%97-,impact%20of%20advanced%20chronic%20kidney%20disease%20stages%20on%20heart%20failure%20mortality%3A%20a%20nationwide%20analysis%20using%20CDC%20WONDER,-Authors
    2. Durrani T, Kakakhel MZJ, Munir SU, et al. Kidney disease and cardiovascular death: a comparative analysis of chronic kidney disease vs. acute renal failure outcomes using CDC WONDER. Presented at: European Society of Cardiology Congress; Madrid, Spain. August 29–September 1. https://esc365.escardio.org/ESC-Congress/abstract?text=chronic%20kidney%20disease&docType=All&days&page=1&vue=cards#:~:text=%C3%97-,Kidney%20disease%20and%20cardiovascular%20death%3A%20a%20comparative%20analysis%20of%20chronic%20kidney%20disease%20vs.%20acute%20renal%20failure%20outcomes%20using%20CDC%20WONDER,-Authors

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  • Ben & Jerry’s founders call for brand to be excluded from Unilever listing | Unilever

    Ben & Jerry’s founders call for brand to be excluded from Unilever listing | Unilever

    The co-founders of Ben & Jerry’s have called for the ice-cream brand to be made independent and excluded from current owner Unilever’s plans to list its ice-cream business on the stock market.

    Ben Cohen and Jerry Greenfield say The Magnum Ice Cream Company (TMICC), a new division of Unilever that is set to be separately listed in November and includes the brand founded by the pair in 1978 alongside Magnum, Cornetto and Wall’s, “must free Ben & Jerry’s” in an open letter to prospective investors and the group’s board.

    The pair, who no longer have a financial interest in Ben & Jerry’s or any formal role, say they “feel compelled to speak out – as concerned individuals”.

    “We are deeply concerned that the commitments made to us, our employees, and our customers are being eroded. For several years now the voice of Ben & Jerry’s has been silenced by Unilever, particularly when the brand has tried to speak out about social justice and unjust wars. That is not the Ben & Jerry’s that we founded, or the one that we envisioned when we agreed to join.”

    The ice-cream company launched in Vermont in the US with a mission to “advance human rights and dignity”.

    The letter says: “We believe that the founding values are central to what Ben & Jerry’s is, and cannot simply be discarded out of convenience or under political pressure.”

    Cohen added: “Ben & Jerry’s was founded on a simple but radical premise: that our business could thrive and make outstanding products whilst standing up for progressive values.

    “We fought to ensure our social justice mission was protected by Unilever when the company was acquired, but over the past several years, this has been eroded, and the company’s voice has been muted. We won’t be silent any more. Authenticity has always been at the very heart of what we do, and stripping this away risks destroying the very value of Ben & Jerry’s. We urge the board and potential investors to rethink the inclusion of Ben & Jerry’s in Magnum’s future makeup and establish a Free Ben & Jerry’s.”

    A spokesperson for TMICC said: “Ben & Jerry’s is a proud part of The Magnum Ice Cream Company and is not for sale. We remain committed to Ben & Jerry’s unique three-part mission – product, economic and social – and look forward to building on its success as an iconic, much-loved business.”

    The latest spat comes after a series of disagreements.

    Last year, Ben & Jerry’s social mission board, an entity that is independent from Unilever, launched legal action against Unilever, accusing its parent company of trying to block the ice-cream brand from making public statements supporting Palestinian refugees in the conflict in Gaza.

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    The lawsuit claimed that Unilever had threatened to dismantle its board and sue directors over the issue.

    Unilever has rejected the claims and said it would “defend our case very strongly”.

    Ben & Jerry’s has also clashed with its parent company over the sale of its products in the Israeli-occupied West Bank.

    Unilever subsequently sold Ben & Jerry’s Israel division to a local operation, prompting the ice-cream maker to sue its parent company before reaching a settlement.

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  • Suryakumar Yadav, Salman Ali Agha call for focus amid India vs Pakistan buzz

    Suryakumar Yadav, Salman Ali Agha call for focus amid India vs Pakistan buzz

    Passion has always been the colour of the India-Pakistan cricket rivalry, regardless of the stage, and it was no surprise when the subject dominated the captains’ press conference on the eve of the Asia Cup 2025 on Tuesday.

    India’s T20 captain Suryakumar Yadav, set to lead his country in a multi-team tournament for the first time, noted that intensity and passion have always been part of the game and cannot be taken away.

    “I’m very excited to take the field on the front foot. Without aggression, I don’t think you can play this sport,” Suryakumar Yadav responded when asked if players would approach the Asia Cup clashes differently.

    Pakistan cricket team‘s Salman Ali Agha, also leading his side into a major competition for the first time, echoed a similar view with a measured stance.

    “You don’t need to say anything to anyone. The fast bowlers always want to be aggressive because that’s what keeps them going. From my side, there is no instruction to anyone as long as they keep it on the ground,” Salman said.

    The 17th edition of the Asia Cup, returning to the T20 format, brings together eight teams.

    Reigning Asia Cup champions India and two-time winners Pakistan are in Group A alongside hosts UAE and Oman. Their group-stage meeting on September 14 in Dubai is already shaping up as one of the tournament’s biggest draws.

    Both captains, though, stressed preparation over narratives. Suryakumar, back after sports hernia surgery, emphasised continuity in India’s approach with team selections.

    “Why mend something that isn’t broken? If something has given us results, why would we change? If your preparations are good, you’ll be confident when you take the field,” he said.

    India, the most successful team in Asia Cup history with eight titles, begin their campaign against the UAE on September 10.

    Pakistan, champions in 2000 and 2012, start against Oman two days later, coming into the tournament fresh from a T20 tri-series win in Sharjah.

    For India, this Asia Cup is also the only multi-team assignment before next year’s T20 World Cup.

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  • Insights on ALONE-AF and AQUATIC Trials

    Insights on ALONE-AF and AQUATIC Trials

    Host Craig Beavers sits down with Lorenz van der Linden, a Belgian pharmacist, to dive deep into 2 groundbreaking trials from the European Society of Cardiology (ESC) 2025 Congress. They explore the ALONE-AF trial, which examined anticoagulation strategies for patients with atrial fibrillation after catheter ablation, and the AQUATIC trial, which investigated the role of aspirin in patients on oral anticoagulation. With their expert analysis, Craig and Lawrence break down the clinical implications, methodological nuances, and potential practice-changing insights from these important cardiovascular studies.

    Show notes:

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  • WCH Tokyo 25 preview: women’s heptathlon | News | Tokyo 25

    WCH Tokyo 25 preview: women’s heptathlon | News | Tokyo 25

    • Nafi Thiam seeks to restore her dominance with a third world title
    • Katarina Johnson-Thompson defends her crown, aiming for back-to-back world titles and a third gold
    • World leader Anna Hall arrives in Tokyo chasing her first global title

    When Nafi Thiam left the 2022 World Championships in Oregon as a double world champion, she seemed untouchable. But in Budapest one year later, it was Katarina Johnson-Thompson who claimed the crown, winning her second global title and reminding the world of her extraordinary resilience.

    Their paths have crossed on the biggest stages for years, and in Tokyo they meet again – Thiam aiming to restore her supremacy, Johnson-Thompson determined to hold on to it.

    Thiam, the only woman in history to win three Olympic titles in the combined events and the world record-holder for the indoor pentathlon, owns a personal best of 7013, dating back to 2017. Johnson-Thompson, Olympic silver medallist with a best of 6981, has rebuilt her career through injuries and setbacks, triumphing again on the biggest stage in Budapest. Both women have proven they can rise to the occasion, and with both chasing a third world title, their latest duel at the World Athletics Championships Tokyo 25 promises to be one of the highlights.

    But it won’t be just the two global champions chasing gold in Tokyo.

    USA’s Anna Hall joined the 7000-point club at the Hypo-Meeting in Götzis earlier this year, scoring 7032 to move to equal second on the world all-time list. Her astonishing series included a 1.95m high jump and a world heptathlon best of 2:01.23 in the 800m. After taking world bronze in 2022 and world silver in 2023, just 20 points shy of gold, Hall heads to Tokyo in search of her first senior global title.

    Many others in the field will also be eager to step on to the podium. Emma Oosterwegel of the Netherlands, the Olympic bronze medallist in this very stadium in 2021, remains a consistent force. Her compatriot Sofie Dokter, world indoor bronze medallist in 2024, continues to make steady progress with a best of 6576.

    Switzerland’s Annik Kälin, fourth in Paris and bronze medallist in the long jump at the World Indoor Championships earlier this year, has raised her level again, setting national records not only in the heptathlon (6639 in 2024), but also in the long jump (6.90m this year).

    Colombia’s Martha Araujo has enjoyed a solid 2025 so far. She inished third in Gotzis with a South American record of 6475 and backed it up with a 6451 victory in Talence.

    The US team is bolstered by world indoor bronze medallist Taliyah Brooks and 2024 Combined Events Tour winner Michelle Atherley.

    Young Finn Saga Vanninen arrives fresh from retaining her European U23 crown, which she did by setting a national record of 6563.

    And then there is Adrianna Sułek-Schubert. The Pole made headlines by joining the exclusive 5000-point club in the pentathlon before stepping away from competition to become a mother. After making her comeback at the Paris 2024 Olympic Games, she continues her search for top form.

    Others to watch include Kate O’Connor, who set an Irish record of 6487 to win the World University Games title, and France’s Auriana Lazraq-Khlass, silver medallist at last year’s European Championships with a breakthrough of 6635.

    Ainhoa Serrano for World Athletics

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  • You could help NASA track its Artemis 2 astronauts’ trip around the moon in 2026

    You could help NASA track its Artemis 2 astronauts’ trip around the moon in 2026

    NASA is asking citizen scientists, space industry employees and other volunteers to help them track the first human mission to the moon in more than 50 years.

    The agency put out a call for volunteers to passively track the Artemis 2 mission’s Orion spacecraft when it launches in April 2026 or thereabouts, to keep an eye as the four astronauts aboard loop around the moon and then come back to Earth.

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  • ‘The Conjuring’ HBO Max Series Sets Nancy Won as Showrunner

    ‘The Conjuring’ HBO Max Series Sets Nancy Won as Showrunner

    “The Conjuring” TV series currently in development at HBO Max has taken a big step forward.

    Variety has learned exclusively from sources that Nancy Won has boarded the project to serve as writer, executive producer, and showrunner. In addition, both Peter Cameron and Cameron Squires are attached to write on the series.

    HBO Max declined to comment.

    The show was first reported to be in development at HBO Max back in 2023. Exact plot details remain under wraps aside from the fact the show will continue the story established in “The Conjuring” film franchise. Peter Safran remains onboard as an executive producer, with James Wan’s Atomic Monster producing. Warner Bros. Television is the studio.

    The news comes just days after “The Conjuring: Last Rites” premiered in theaters. The fourth film in “The Conjuring” franchise has gone over like gangbusters at the box office, grossing over $194 million worldwide so far.

    The first “The Conjuring” film debuted in 2013. The films star Patrick Wilson and Vera Farmiga as paranormal investigators Ed and Lorraine Warren as they take on different supernatural cases. In addition to the four main films, “The Conjuring” has also spawned the spinoff franchises “Annabelle” and “The Nun,” which have produced three and two films respectively to date. Collectively, the films have grossed nearly $2.5 billion worldwide.

    Won’s recent TV writing credits include “Sunny” at Apple TV+, “Tiny Beautiful Things” and “Little Fires Everywhere” at Hulu, and the Marvel series “Jessica Jones” at Netflix. She is also known for her work on “Jericho” and “Supernatural” among several other series.

    Both Cameron and Squires have worked on multiple Marvel projects in recent years. Cameron has written for the special “Werewolf by Night” as well as for shows like “Agatha All Along,” “Moon Knight,” and “WandaVision.” Squires also wrote for “Agatha All Along” and “WandaVision” as well as shows such as “Agent Elvis,” the “Star Wars” series “The Acolyte,” and Season 2 of “The Boys” companion series “Gen V.”

    Won is repped by UTA. Cameron is repped by Verve, Untitled, and Johnson Shapiro Slewett & Kole. Squires is repped by CAA, Artists First, and Johnson Shapiro Slewett & Kole.

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  • Double-Dose Firmonertinib Showing Promising Activity in First-Line EGFR L858R–Mutated NSCLC

    Double-Dose Firmonertinib Showing Promising Activity in First-Line EGFR L858R–Mutated NSCLC

    EGFR L858R–Mutated NSCLC | Image by

    Ashling Wahner & MJH Life Sciences Using AI

    Dual-dose firmonertinib was safe and active for the frontline treatment of patients with EGFR L858R–mutated non–small cell lung cancer (NSCLC), according to data from the phase 2 FIRM Study (ChiCTR2200060897) presented during the International Association for the Study of Lung Cancer 2025 World Conference on Lung Cancer.1

    At the February 16, 2025, data cutoff, at a median follow-up of 18.1 months, the median progression-free survival (PFS) among patients who received firmonertinib was 21.1 months (95% CI, 17.5-not reached [NR]). The 18-month PFS rate was 59.7% (95%, 44.1%-80.8%).

    “Double-dose firmonertinib exhibited promising efficacy and safety in this trial, supporting its use as a first-line option for patients with EGFR L858R–mutated [NSCLC],” Meiqi Shi, MD, of the Department of Medical Oncology at Jiangsu Cancer Hospital in Nanjing, China, and coauthors wrote in a poster presentation of the data.

    What Were the Methods and Baseline Characteristics of the FIRM Study?

    The FIRM Study was a prospective, multicenter, open-label, single-arm study that enrolled patients with EGFR L858R–mutated advanced NSCLC in China.1,2 Eligible patients needed to be at least 18 years of age, have received no prior systemic anti-tumor therapy, have an ECOG performance status of 0 or 1, and have a life expectancy of at least 12 weeks.2 Patients with asymptomatic brain metastases were allowed to be included in the study.

    All patients received oral firmonertinib at 160 mg once daily. The primary end point was investigator-assessed PFS.1 Secondary end points included overall response rate (ORR), disease control rate (DCR), 18-month PFS rate, overall survival (OS), and safety. Dynamic changes of circulating tumor DNA (ctDNA) at baseline, day 1 of cycle 3, and disease progression were assessed as exploratory end points.

    At baseline, the median age was 65 years (range, 47-80). Most patients were female (51.5%), had stage IV disease (90.9%), and were never smokers (66.7%). All patients had an ECOG performance status of 1 and adenocarcinoma.

    What Were the Additional Efficacy and Safety Data?

    Further efficacy data revealed that the ORR was 75.8% (95% CI, 57.7%-88.9%); all responses were partial. Patients achieved stable disease at a rate of 15.2% and 6.1% had disease progression. The DCR was 90.9% (95% CI, 75.7%-98.1%). The median OS was NR (95% CI, NR-NR), and the 12-month OS rate was 96.6% (95% CI, 90.1%-100%).

    In terms of safety, 90.9% of patients experienced any-grade treatment-emergent adverse effects (TEAEs). The most common any-grade TEAEs included lymphopenia (39.4%), increased creatine phosphokinase levels (39.4%), diarrhea (36.4%), and increased creatinine levels (33.3%). Grade 3 or higher TEAEs were reported in 6.1% of patients. Notably, no patients had dose reductions, treatment discontinuations, or died.

    Data from an exploratory analysis, which included 28 patients with available plasma samples, showed that ctDNA was detected in 92.9% of patients at baseline, fell to 32.0% (n = 8 of 25) at day 1 of cycle 3, and rose to 78.6% (n = 11 of 14) at the time of disease progression. The median variant allele frequency (VAF) fell from 1.1% to 0% at baseline to day 1 of cycle 3 (P < .001), then rose to 0.08% at disease progression.

    Patients with ctDNA positivity at day 1 of cycle 3 (n = 17) had a median PFS of 23.4 months (95% CI, 18.9-NR) compared with 10.7 months (95% CI, 9.9-NR) among patients who were negative for ctDNA at the same time point (HR, 4.3; 95% CI, 1.4-13.1; P = .006).

    “ctDNA analysis demonstrates its significant clinical value for efficacy monitoring and provides new insights for precise treatment strategies based on biomarker-driven stratification,” the study authors wrote in their conclusion.

    References

    1. Shi M, Shen B, Wang C, et al. Phase II trial of first-line double-dose firmonertinib in locally advanced or metastatic NSCLC with EGFR L858R (FIRM Study). Presented at: International Association for the Study of Lung Cancer 2025 World Conference on Lung Cancer; September 6-9, 2025; Barcelona, Spain. Abstract P3.12.01.
    2. High dose Firmonertinib in treatment naive advanced non-small cell lung cancer patients harbouring EGFR Exon 21 L858R mutation: a prospective, multicenter, single arm, open label study. Chinese Clinical Trial Registry. Updated on April 15, 2025. Accessed September 9, 2025. https://www.chictr.org.cn/showproj.html?proj=171715

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  • Nepal parliament set on fire after PM resigns over anti-corruption protests

    Nepal parliament set on fire after PM resigns over anti-corruption protests

    Prime Minister KP Sharma Oli has resigned amid Nepal’s worst unrest in decades, as public anger mounts over the deaths of 19 anti-corruption protesters in clashes with police on Monday.

    On Tuesday, crowds set fire to parliament in the capital Kathmandu, sending thick black smoke billowing into the sky. Government buildings and the houses of political leaders were attacked around the country.

    Three more deaths were reported on Tuesday. Amid the chaos, jail officials said 900 inmates managed to escape from two prisons in Nepal’s western districts.

    The demonstrations were triggered by a ban on social media platforms. It was lifted on Monday – but by then protests had swelled into a mass movement.

    Nepal’s army chief issued a statement late on Tuesday accusing demonstrators of taking advantage of the current crisis by damaging, looting and setting fire to public and private property.

    It said if unrest continued, “all security institutions, including the Nepal Army, are committed to taking control of the situation,” effective from 22:00 local time (16:15 GMT; 17:15 BST), without detailing what this might entail.

    While the prime minister has stepped down, it’s not clear who will replace him – or what happens next, with seemingly no-one in charge. Some leaders, including ministers, have reportedly taken refuge with the security forces.

    So far, the protesters have not spelt out their demands apart from rallying under the broader anti-corruption call. The protests appear spontaneous, with no organised leadership.

    Inside parliament, there were jubilant scenes as hundreds of protesters danced and chanted slogans around a fire at the entrance to the building, many holding Nepal’s flag.

    Some entered inside the building, where all the windows have been smashed. Graffiti and anti-government messages have been spray painted on the exterior.

    Kathmandu resident Muna Shreshta, 20, was among the large crowd outside parliament.

    Corruption has been a long-term issue, she told the BBC, adding that it is “high time our nation, our prime minister, and anyone in power changes, because we need to change”.

    “It has happened now and we are more than happy to witness this and fight for this. I hope this change will bring something that is positive to us.”

    Ms Shreshta thinks taxes paid by working people need to be used in ways that will help the country grow.

    Last week, Nepal’s government ordered authorities to block 26 social media platforms for not complying with a deadline to register.

    Platforms such as Instagram and Facebook have millions of users in Nepal, who rely on them for entertainment, news and business.

    The government justified its ban in the name of tackling fake news, hate speech and online fraud.

    But young people criticised the move as an attack on free speech.

    Although the ban was hastily lifted on Monday night, the protests had already gained unstoppable momentum, targeting the political elite and plunging the nation into chaos.

    A government minister said they lifted the ban after an emergency meeting late on Monday night to “address the demands of Gen Z”.

    In the weeks before the ban, a “nepo kid” campaign, spotlighting the lavish lifestyles of politicians’ children and allegations of corruption, had taken off on social media.

    Thousands of young people first attempted to storm the parliament building on Monday. Several districts were put under curfew. Most of the deaths occurred around parliament and government buildings on that day.

    On Tuesday, protests continued unabated. A crowd in Kathmandu torched the headquarters of the Nepali Congress Party, which is part of the governing coalition, and the house of its leader, Sher Bahadur Deuba.

    The house of KP Oli – a 73-year-old four-time prime minister who leads the Communist Party – was also set on fire.

    He said he had resigned to pave the way for a constitutional solution to the current crisis.

    “In view of the adverse situation in the country, I have resigned effective today to facilitate the solution to the problem and to help resolve it politically in accordance with the constitution,” Oli wrote in his letter to President Ramchandra Paudel.

    An aide to Paudel told Reuters news agency the president had accepted the resignation and begun the “process and discussions for a new leader”.

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  • US container imports up in August, tariff turmoil dims year-end outlook – Reuters

    1. US container imports up in August, tariff turmoil dims year-end outlook  Reuters
    2. SHIPPING: Asia-US container rates face downward pressure as imports wane on rising tariffs  ICIS
    3. U.S. Imports Set to Drop as Tariffs Bite  The Wall Street Journal
    4. US container imports hold steady as China volumes decline in August  Yahoo Finance
    5. Tariffs Expected To Dampen Port Traffic For The Rest Of 2025  Store Brands

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