The Pakistan cricket squad arrived in Lauderhill, Florida, on Sunday via Dubai in two separate groups, ahead of the three-match T20 International series against the West Indies next month.
According to details, the second group comprising Mohammad Haris, Hussain Talat, Hasan Nawaz, Sahibzada Farhan, along with the coaching and support staff, departed recently and has now joined the squad in the USA.
The first group, including T20I captain Agha Salman, Saim Ayub, Fakhar Zaman, Mohammad Nawaz, Abrar Ahmed, Khushdil Shah, and Faheem Ashraf, had already left for Lauderhill on Friday.
Meanwhile, emerging pacers Ahmed Daniyal, Salman Mirza, and Abbas Afridiwho failed to retain their places in the squadhave returned to Pakistan from Dhaka.
The Men in Green will begin the tour with a three-match T20I series against the West Indies, with fixtures scheduled for July 31, August 2, and August 3 at the Central Broward Park & Broward County Stadium in Lauderhill, USA.
All-rounder Agha Salman will lead the T20I side, which sees the return of key pacers Haris Rauf, Hasan Ali, and Shaheen Shah Afridi.
Following the T20Is, both teams will contest a three-match ODI series, set to be played at the Brian Lara Cricket Academy in Trinidad and Tobago on August 8, 10, and 12.
Wicketkeeper-batter Mohammad Rizwan will captain the 16-member ODI squad, which includes one uncapped player, Hasan Nawaz.
Senior stars Babar Azam and Shaheen Shah Afridi have been recalled to strengthen the lineup for the 50-over format.
Pakistan T20I Squad: Salman Ali Agha (c), Abrar Ahmed, Faheem Ashraf, Fakhar Zaman, Haris Rauf, Hasan Ali, Hasan Nawaz, Hussain Talat, Khushdil Shah, Mohammad Haris (wk), Mohammad Nawaz, Sahibzada Farhan (wk), Saim Ayub, Shaheen Shah Afridi and Sufiyan Muqeem.
Pakistan ODI Squad: Mohammad Rizwan (c), Salman Ali Agha (vc), Abdullah Shafique, Abrar Ahmed, Babar Azam, Faheem Ashraf, Fakhar Zaman, Hasan Ali, Hasan Nawaz, Hussain Talat, Mohammad Haris (wk), Mohammad Nawaz, Naseem Shah, Saim Ayub, Shaheen Shah Afridi and Sufiyan Muqeem.
Doubtful Shadab
Pakistan’s T20 vice-captain Shadab Khan is likely to miss the Asia Cup 2025, scheduled to take place in the UAE from September 9 to 28, as he continued to recover from shoulder surgery.
The all rounder underwent successful surgery in the UK earlier in July after sustaining a shoulder injury, which had already ruled him out of the three match T20I series against Bangladesh and the ongoing West Indies tour.
According to sources, Shadab will need a minimum of three months to regain full fitness and return to competitive cricket.
This timeline made his participation in the Asia Cup highly unlikely, with his return expected only in October.
The Pakistan Cricket Board (PCB) has not yet named a replacement for the deputy captaincy role.
During the Bangladesh series, no vice captain was appointed in Shadab’s absence and the squad announced for the West Indies tour also did not include a designated deputy to skipper Salman Ali Agha.
The PCB has yet to release an official timeline for his recovery or confirm any plans for a potential return.
For the unversed, the Asian Cricket Council (ACC) recently unveiled the highly anticipated schedule for the Men’s Asia Cup 2025, confirming that arch-rivals India and Pakistan will lock horns on September 14 in the UAE.
This edition of the continental event will follow the T20 format, serving as a crucial warm-up ahead of the ICC T20 World Cup 2026, co-hosted by India and Sri Lanka.
The tournament features eight teams split into two groups. Group A consists of India, Pakistan, UAE, and Oman, while Group B includes Bangladesh, Afghanistan, Sri Lanka and Hong Kong.
The event kicks off on September 9 with the curtain-raiser between Afghanistan and Hong Kong.
Pakistan will begin their campaign against Oman on September 12, followed by the high-voltage clash against India two days later.
The media rights for the Asia Cup have not yet been sold in Pakistan. The Indian broadcaster has demanded $12 million, and Pakistani TV channels are in talks to reduce the amount. At the same time, discussions are ongoing among the channels to form a consortium.
According to details, the Asia Cup is scheduled to be held from September 9 to 28 in the UAE, featuring 19 matches. If both teams reach the final, three India-Pakistan matches are expected.
Last year, the Asian Cricket Council sold the 8-year media rights (from 2024 to 2031) to Sony India for $170 million (approximately PKR 47.26 billion). These rights include four men’s and four women’s Asia Cups, as well as 119 matches including the Emerging Cup.
Currently, negotiations are underway for the sale of broadcasting rights in Pakistan. Sources reveal that the Indian broadcaster has demanded $12 million for the two Asia Cups. However, none of the three Pakistani channels currently in the race is willing to pay such a high amount. According to them, the current market is not strong enough to ensure profit on such a large investment.
Talks have also been held among the channels to form a consortium. Only in that case will Sony’s demand be met; otherwise, negotiations to reduce the fee will continue.
The digital rights for the Asia Cup in Pakistan have already been finalized, and the announcement is expected on Monday. During the recent series against Bangladesh, the state TV channel reportedly made a profit from broadcasting after a long time.
Sources also said that Pakistan’s share in ACC media rights is around 25% (approximately $42.5 million), while digital rights are separate. The majority of the revenue (about 65%) comes from India, meaning that the broadcaster stands to make a significant profit if the Asia Cup takes place.
(Bloomberg) — Wall Street traders left stocks at all-time highs while the dollar climbed the most since May, with a tariff deal between President Donald Trump and the European Union bolstering hopes for an extension of a China trade truce. Treasuries edged lower.
The start of a week that will set the tone for the rest of the year in markets saw a dollar gauge up nearly 1%. The euro slid the most in over two months. The S&P 500 briefly topped 6,400 to close little changed. Treasuries barely budged amid mixed results from US debt sales. Oil rose as Trump said he’d shorten his timeline for Russia to reach a truce with Ukraine.
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In the run-up to the Aug. 1 US tariff deadline, traders will go through a raft of key data from jobs to inflation and economic activity. The big event comes Wednesday, when the Federal Reserve is expected to keep rates unchanged. Then there’s a string of big-tech earnings, with four megacaps worth a combined $11.3 trillion reporting results.
“This is about as busy as a week can get in the markets,” said Chris Larkin at E*Trade from Morgan Stanley. “This week could make or break that momentum in the near term.”
US and Chinese officials finished the first of two days of talks aimed at extending their tariff truce beyond a mid-August deadline and hashing out ways to maintain trade ties while safeguarding economic security. Canada Prime Minister Mark Carney said his government is still deep in trade talks with the Trump administration.
The Treasury jacked up its estimate for federal borrowing for the current quarter to $1 trillion, mainly due to distortions from the debt limit. On Wednesday, the department will announce its plans for note and bond sales over coming months — which dealers widely see as staying unchanged.
Speaking in Scotland on Sunday to announce the EU deal, Trump gave a brief update on Washington’s relations with Beijing. “We’re very close to a deal with China. We really sort of made a deal with China, but we’ll see how that goes,” he said without elaborating.
“It is possible that as more trade deals are announced, the level of uncertainty that has hovered over business and the economy will ease,” said Brent Schutte at Northwestern Mutual Wealth Management Co. “Additionally, the impact of final trade deals could be less than originally forecast after the April 2 announcement of reciprocal tariffs.”
To Thierry Wizman at Macquarie Group, while the dollar’s strength today may reflect the perception that the new EU deal is lopsided in favor of the US, it may also reflect a feeling that America is reengaging with its major allies.
“Whether we agree or not with the use of tariffs and the deals announced, we are getting the big ones out of the way which will allow American businesses to adjust and plan, for better or worse,” said Peter Boockvar at the Boock Report. “And we can now focus on how this all plays out.”
Fed Chair Jerome Powell and his colleagues will step into the central bank’s board room for a two-day meeting starting Tuesday to deliberate on rates at a time of immense political pressure, evolving trade policy, and economic cross-currents.
In a rare occurrence, policymakers will convene in the same week that the government issues reports on gross domestic product, employment and the Fed’s preferred price metrics. Forecasters anticipate the heavy dose of data will show economic activity rebounded in the second quarter.
While the stock market is moving sideways after a solid run, “if we get no surprises in earnings and some dovish comments by the Fed, it’s likely we’ll see yet more new highs by the end of the week,” said Louis Navellier, chief investment officer at Navellier & Associates.
“We do not expect the Federal Reserve to cut interest rates on Wednesday, but it’s possible that they make a stronger signal that cuts are on the horizon in the fall, especially as the inflation data continues to stay muted even in this tariff environment,” said Rick Gardner at RGA Investments.
Gardner also says that while stock market valuations are high, that in and of itself is not a reason why valuations can’t expand even further from here.
In fact, this earnings season is off to a solid start, and all eyes will be on results from Microsoft Corp. and Meta Platforms Inc. on Wednesday, and Apple Inc. and Amazon.com Inc. on Thursday.
So far, Corporate America appears to be taking tariffs in stride. With about a third of S&P 500 firms having reported, roughly 82% have beaten profit forecasts, on track for the best quarter in about four years, data compiled by Bloomberg Intelligence show.
Progress in trade negotiations will take the S&P 500 to a third consecutive year of 20% gains, according to Oppenheimer Asset Management’s John Stoltzfus, a feat unseen since the late 1990s. He raised his year-end target for the US benchmark to 7,100.
Some market forecasters including Morgan Stanley’s Michael Wilson have turned more optimistic about the S&P 500 as they expect earnings to remain upbeat.
The technical evidence suggests a broadening of participation in equities off the April low, according to Craig Johnson at Piper Sandler.
“Despite a slight easing in momentum as investors await earnings, the combination of several major indices at all-time highs and improving market breadth continues to draw investors off the sidelines, offering opportunities to buy the dip,” he said.
At RBC Capital Markets, Lori Calvasina says it would be premature to write off the impact of tariffs on inflation and corporate earnings.
“It also poses a risk to the path of stock prices if company outlooks for 2026 don’t end up being as rosy as investors have been anticipating,” she noted.
The S&P 500 is trading around 22.5 times projected earnings, compared to a 10-year average of 18.6. That’s sparked concerns that there may be little room for error.
The stock market’s stunning rebound and resilience have again emboldened equity investors, who have developed muscle memory around ‘buying the dip’,” according to Lisa Shalett at Morgan Stanley Wealth Management.
“With volatility having decoupled from stress indicators, passive indexes have ground to new highs, while the most speculative corners of the market have begun to lead,” she said. “Complacency is elevated, and valuations are rich. In this environment, we want to be stock-pickers.”
To Mark Hackett at Nationwide, this may be the most compelling intersection of technical momentum and fundamental strength we’ve seen in a long time.
“The S&P hasn’t had a 1% move in over a month and yet bears have capitulated,” he said. “No one’s willing to short this market, and even typically skeptical investors are getting pulled in. While it’s not a blow-off top yet, the odds of that happening are rising.”
If sentiment keeps shifting and dip buyers remain aggressive, we could see a classic melt-up – and any near-term weakness over the next several weeks is likely to be bought aggressively, he said.
“However, for now, bears are hibernating through the summer,” Hackett concluded.
“We would lean toward being more bullish than bearish on US stocks through year-end, but not outside of a balanced portfolio based on risk,” said Anthony Saglimbene at Ameriprise. “However, that view is contingent on positive corporate profitability and economic growth this year, avoiding worst-case tariff scenarios, and investors remaining willing to ‘buy the dip’.”
Markets have found reassurance in several developments, according to Invesco Global Market Strategy Office.
“For one, the worst fears that manifested around trade in early April haven’t materialized, and key trade agreements are being signed,” the strategists said. “Tariff rates remain vastly elevated compared to last year, but they appear manageable. In our view, it’s likely that the cost can be shared between businesses and consumers without a meaningful impact on growth or inflation.”
Invesco strategists also noted that what should really matter for stocks in the medium and long-term is earnings.
“After a strong market rally, investors should prepare for renewed volatility in the near term,” said Mark Haefele at UBS Global Wealth Management. “Potential market dips could offer an opportunity for investors to build long-term exposure to stocks.”
Corporate Highlights:
Samsung Electronics Co. will produce AI semiconductors for Tesla Inc. in a new $16.5 billion pact that marks a win for its underperforming foundry division.
Texas Instruments Inc. was upgraded to outperform at Wolfe Research, which said the chipmaker is “near the end” of a spending cycle.
Cisco Systems Inc. was downgraded to inline at Evercore, which mentioned valuation following recent gains.
Nike Inc. was raised to overweight at JPMorgan Chase & Co., which cited the earnings impact of the sportswear maker’s five-pronged multi-year recovery plan.
Albertsons Cos. demanded that Kroger Co. provide details on personal conduct that led the company to replace its chief executive officer, who shepherded the failed $24.6 billion takeover that’s now the focus of litigation between the two companies.
PayPal Holdings Inc. will soon allow businesses to accept more than one hundred cryptocurrencies at checkout.
Roche Holding AG plans to test whether an experimental medicine can prevent Alzheimer’s disease symptoms in high-risk people, its latest investment in one of the most failure-prone areas of drugmaking.
Arrowhead Pharmaceuticals Inc. said Monday that it’s owed a $100 million milestone payment from Sarepta Therapeutics Inc. within the next two months, pressuring the beleaguered biotech company just days after it stopped selling its biggest drug due to safety concerns.
EssilorLuxottica SA posted better-than-expected revenue in the second quarter, as the world’s biggest eyewear maker showed strong gains in Europe and pressed ahead with its smart-glasses initiative.
Warner Bros. Discovery Inc. announced the names of the two companies resulting from a planned separation of the streaming and studios business from its cable-TV networks.
What Bloomberg Strategists say…
“A European trade deal and new China talks will go a long way to bolster risk sentiment in the days ahead, with the Aug. 1 deadline now largely irrelevant. With some level of framework in place for Europe, China and Japan, investors are gaining more visibility into the contours of global trade — and so far, they’re not particularly worried.”
—Tatiana Darie, Macro Strategist, Markets Live
For the full analysis, click here.
Some of the main moves in markets:
Stocks
The S&P 500 was little changed as of 4 p.m. New York time
The Nasdaq 100 rose 0.4%
The Dow Jones Industrial Average fell 0.1%
The MSCI World Index fell 0.3%
Bloomberg Magnificent 7 Total Return Index rose 0.8%
The Russell 2000 Index fell 0.2%
Currencies
The Bloomberg Dollar Spot Index rose 0.8%
The euro fell 1.3% to $1.1592
The British pound fell 0.6% to $1.3355
The Japanese yen fell 0.6% to 148.56 per dollar
Cryptocurrencies
Bitcoin fell 0.6% to $118,128.17
Ether fell 0.6% to $3,802.22
Bonds
The yield on 10-year Treasuries advanced two basis points to 4.41%
Germany’s 10-year yield declined three basis points to 2.69%
Britain’s 10-year yield advanced one basis point to 4.65%
Commodities
West Texas Intermediate crude rose 3% to $67.10 a barrel
Beyoncé has set several new records after wrapping her wildly successful Cowboy Carter tour, which now holds the distinction of being the highest-grossing country tour ever.
The 32-show run tour grossed a whopping $407.6 million with 1.6 million tickets sold, according to Billboard Boxscore. (Boxscore has been collecting touring data and figures from various industry sources — artists, venues, promoters — for almost 40 years.)
Additionally, Pollstar, the trade publication for the concert industry, credited the Cowboy Carter Tour with making over $400 million, a feat that no other country tour has ever achieved. They also noted Beyoncé is the first American artist to have two separate tours gross over $400 million, with her 2023 Renaissance trek amassing $579 million across 56 shows.
That the Cowboy Carter trek made as much as it did with 24 fewer shows is another remarkable feat. It’s now the shortest tour ever to reach $400 million in gross, per Boxscore, with its closest competitors lagging far behind. Those include the Renaissance run (56 dates), The Rolling Stones’ 2017 – 2021 No Filter Tour (58 dates), and Metallica’s ongoing M72 World Tour (60 so far).
After her comparatively lengthy Renaissance tour — which was also her first headlining run since the 2016 Formation World Tour — Beyoncé took a slightly different approach with the Cowboy Carter, scheduling more shows in fewer locations. In total, she played just nine cities, but her itinerary included five nights in Los Angeles and the New York City area, as well as six gigs in London. She wrapped the run this month with a four-night stand in Atlanta, followed by two nights in Las Vegas.
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While Cowboy Carter was, of course, the focus of the tour, the setlist featured highlights from throughout Beyoncé’s career, as well as nightly cameos from her children, Blue Ivy and Rumi. During Beyoncé’s June 19 show in Paris, she welcomed Miley Cyrus onstage for the live premiere of “II Most Wanted.” And at the tour finale in Vegas, there were appearances from Jay-Z and Shaboozey, as well as a Destiny’s Child reunion.
The end of the Cowboy Carter tour likely marks the conclusion of the second act of Beyoncé’s planned album trilogy, which began with Renaissance. On top of the wildly successful tour, Cowboy Carter also marked a major musical milestone for Beyoncé as she finally won the Grammy for Album of the Year.
Budapest was bittersweet for Masai Russell. While disappointed at the time, the US hurdler believes that World Championships experience in 2023 helped to put her on track for Olympic gold in Paris.
The 25-year-old reached the semifinals of the 100m hurdles in Budapest but became the Olympic champion less than a year later. Now she is also the second-fastest 100m hurdler in history thanks to her 12.17 performance in Florida in May.
Taking things meeting by meeting, Russell’s next target is the US Championships, taking place in Eugene from 31 July to 3 August, as she aims to book her place on the team for the World Athletics Championships Tokyo 25 in September.
“I think it had to happen for me to become who I am now,” says Russell, reflecting on the World Championships in Budapest. “I had to take a step back. I think I was a little ahead of myself and I thought that I was going to do something that I wasn’t ready for. I was just glad that I was able to get that opportunity to run at Budapest and run on that global stage so then at the next major championship, which was the Olympics, I had that experience.
“As much as Budapest hurt – it broke my heart – I had to go through that to get to where I am now.”
View the full interview on World Athletics Watch
Russell clocked her North American record of 12.17 – a mark just 0.05 off the world record – at the Grand Slam Track meeting in Miami and was followed by her compatriot Tia Jones who moved to third on the world all-time list with 12.19. While Russell wasn’t surprised by her own time, she was shocked by how early in the season she was able to achieve it.
“Whatever’s meant for me is going to happen, and whatever’s meant to be will be,” she says. “So, if that’s me breaking the world record or if that’s me running sub-12, however that looks, I just believe whatever’s meant for me will never miss me as long as I’m doing what I’m supposed to do.
“The evolution of the women’s hurdles, it just shows that when one person does something, the next person believes that they can do it,” she adds. “Trackflation, that’s what they’re calling it. It’s just going crazy because everyone in every event is running crazy fast, but the women’s hurdles, it’s just sick.”
Now she is ready to take on some of her fellow best in the world as she races for a place in Tokyo.
“I was more nervous at the US Championships than I was at the Olympic final,” she explains, remembering 2024. “At the Olympic final I’m like I’m here, the time is now – there’s nothing to lose. Whereas, you have everything to lose at the championships for the United States because you might not get that opportunity, so you have to make it count.”
Matthew Lawrence’s comment at San Diego Comic-Con over the weekend on Krypto, the canine star of James Gunn’s Superman, has sparked online debate about the importance of the CGI four-legged friend to the titular hero — and prompted some to suggest the actor rewatch the film’s final scene.
Lawrence was at Comic-Con to promote his new graphic novel with his brothers, The Lawrence Brothers Detective Agency, and during an interview with The Hollywood Reporter at our onsite suite, he drew a question from our popcorn bucket asking if he’s seen Superman. The actor took it as an opportunity to pontificate about the role the dog plays in the movie and to David Corenswet’s titular character.
“This really got me,” Lawrence said. “I’m a huge animal lover. I work in conservation. I have more pets than I can count, most of them reptiles and amphibians, but I’ve had some amazing connections with dogs over the years, and that is not the relationship that I wanted to see. I think it needed more heart. It needed more depth. He was kind of like: ‘This dog. I don’t really care about this dog.’”
Lawrence is interrupted by his brother, Andrew, who corrects the record, telling him how in the movie, Superman was “just watching the dog.” This fact is revealed at the end of the film when (spoiler alert!) an inebriated Supergirl (Milly Alcock) arrives at the Fortress of Solitude to collect her feisty pet. It’s also mentioned in dialogue throughout the blockbuster action hit that little Krypto does not belong to Superman. Either ignoring or not hearing the interjection from his brother, Lawrence continued his critique.
“I think … if you’ve had a dog and you had a real connection with your dog, that is not it. And I wish I would have seen that, because it always needs to be highlighted,” he concluded.
A clip of the interview moment posted to THR’s X account was quick to receive comments pointing out this plot revelation of Krypto’s true master at the end of the movie. Several users also debated the significance of the entirely CGI pooch to the plot of the movie, which sees Superman travel into a pocket dimension to retrieve the pet, who manages to help save the day more than once before the movie concludes.
The dog is not his and krypto is fucking up his place and it’s not a trained dog.
He also literally risks his life to go save krypto and Louis even challenged him on that.
“The dog is not his and krypto is fucking up his place and it’s not a trained dog. He also literally risks his life to go save krypto and Louis even challenged him on that. Idk what bro is on about 🤔.” X user xblazrx wrote.
User @house of woes agreed with Lawrence, writing on X, “Loved Superman but he’s right” and that, “Krypto was just a tad off tonally for me.” “Even after his parents evil reveal his main concern was finding krypto . He was whistling every time he got a chance. Only time he lost his cool was when he confronted lex for his dog . Also, krypto cried and didn’t want him to leave at the start of movie so that explains a bond,” shared @bullseye0777.
Lawrence’s read of the dog-superhero relationship isn’t entirely off base, as some frostier moments between the pup and man of steel are peppered throughout the movie. His heart is certainly in the right place, but he may want to check out Superman again. In the meantime, the actor’s graphic novel with his brothers, Joey and Andrew, was launched at Comic-Con via a Kickstarter, and the brothers have designs on an expansion into an animated and live-action show in which they run a detective agency.
Krypto, the CGI rendering of a mixed-breed pooch who steals many scenes in Gunn’s box office smash, is based on a rendering of the filmmaker’s rescue dog, Ozu.
Mapping transcription factor (TF) binding sites across the genome is key to understanding how cells control gene expression, yet pinpointing their footprints across the genome—especially in single cells or small samples—has remained a technical bottleneck in the fields of molecular biology, genetics, and epigenetics. A new technique called DynaTag may be a promising new approach to understanding TF landscapes.
In a study titled “DynaTag for efficient mapping of transcription factors in low-input samples and at single-cell resolution,” published in Nature Communications, DynaTag (cleavage under Dynamic targets and Tagmentation) enables high-resolution mapping of transcription factor binding sites—even from low-input or single-cell samples. The method, developed by researchers at the University of Cologne, relies on a physiological salt buffer to preserve TF–DNA interactions that are typically lost during sample processing with standard high-salt protocols. “TF–DNA interactions are sensitive to these stringent conditions, causing their dissociation from chromatin and incompatibility with these tagmentation-based technologies,” reported the researchers. DynaTag utilizes a physiological intracellular salt solution throughout all nuclei handling steps to retain specific interactions while suppressing nonspecific protein–DNA interactions, added the research team.
“DynaTag outperforms existing methods such as ChIP-seq and CUT&RUN in terms of sensitivity and resolution,” said senior author Robert Hänsel-Hertsch, PhD, principal investigator at the Center for Molecular Medicine Cologne (CMMC). “The new method delivers high-resolution mapping of the DNA regions where transcription factors bind.”
Using DynaTag, the team profiled 15 transcription factors in both stem cell and cancer models. In embryonic stem cells, the method revealed dynamic binding patterns for factors such as NANOG, MYC, and OCT4 as cells transitioned to an epiblast-like state. Single-nuclei DynaTag further showed that distinct TF occupancy patterns were enough to distinguish cell states, highlighting its utility in developmental biology and heterogeneous tissue analysis.
The authors also applied DynaTag to small cell lung cancer (SCLC), a fast-growing cancer type notorious for its resistance to therapy. In a patient-derived mouse model, the researchers used DynaTag to compare TF binding before and after chemotherapy. They found that the transcription factors FOXA1 and MYC showed increased occupancy in chemotherapy-resistant tumors, while factors like ASCL1 and POU2F3 declined. Likewise, the results further showed significantly increased FOXA1 and MYC occupancies at genes involved in several metabolic pathways, such as fatty acid metabolism.
Intriguingly, the method also suggested a gain-of-function for a mutant p53 variant (R248Q), which became more active at genes linked to epithelial-mesenchymal transition (EMT)—a potential route for cancer cells to escape treatment. These insights, the researchers say, were not detectable using alternative methods like ATAC-seq footprinting.
“It had already been established that certain signaling pathways promoting resistance or metastasis are activated after chemotherapy in small cell lung cancer. However, it was not known which transcription factors regulate these signaling pathways,” said Hänsel-Hertsch. “With the help of DynaTag, we were able to identify specific transcription factors that show increased binding to genes belonging to these signaling pathways after chemotherapy and are likely to promote further tumor growth.”
From this paywalled report at Punchbowl News, as quoted by Taegan Goddard at Political Wire:
“The Senate GOP campaign arm is warning that Apple’s new
iOS update could cost them $25 million in fundraising revenue, as
well as priceless GOTV opportunities,” Punchbowl News
reports.
Here’s a copy of the original memo from the NRSC (National Republican Senatorial Committee). What they’re freaking out about is the new iOS 26 Messages feature (which will be available in Messages on iPadOS and MacOS 26 too — but because these messages are sent as SMS and because the iPhone is so many people’s primary or sole messaging device, it’s the platform they’re focusing on) that will automatically sort messages from unknown senders into a new “Unknown Sender” inbox.
Quoting from the NRSC letter (emphasis in original):
Apple’s iOS 26 update introduces aggressive message filtering.
Political texts — even from verified and compliant senders-will
be treated as spam by default, silently sent to an “Unknown” inbox
with no alerts or notifications. That change has profound
implications for our ability to fundraise, mobilize voters, and
run digital campaigns.
It’s important to understand: Apple isn’t just targeting cold
outreach or spammy actors. Every political message — shortcode,
long code, doesn’t matter-gets pushed into the dark. The only
workaround-getting a voter to reply — is increasingly rare and
entirely at the mercy of Apple’s unclear rules. How will a voter
reply if they never get the message?
Apple’s “rules” for this new feature aren’t unclear at all. If a sender is not in your saved contacts and you’ve never sent or responded to a text message from them, they’re considered “unknown”. That’s it. The feature isn’t even really new — you’ve been able to filter messages like this in Messages for years now, but what iOS 26 changes is that it now will be on by default and has a new more prominent — better, IMO — interface for switching between filter views. Update: I was wrong that this filtering will be on by default in iOS 26 — I was fooled because I had previously enabled “Filter Unknown Senders” in Settings → Apps → Messages → Unknown & Spam (which you need to scroll down quite a bit to get to). I do think, though, that many more iOS users will be using this feature starting with iOS 26 — it’s both better designed and less hidden.
Back to the NRSC letter:
Here’s the shift in practice. Today, a voter with an iPhone gets
our message just like a normal text. In iOS 26, unless that
person has already replied, our message is silently sent to the
“Unknown” inbox. No ping, no badge, just buried in an inbox few
people ever check.
We’ve spent years complying with rigorous standards — providing full
documentation, opt-in proof, and message samples via Campaign
Verify and The Campaign Registry — yet Apple ignores that. Carriers
respect it. Apple doesn’t.
Estimated prospecting losses: NRSC alone could see a $25M+
revenue hit. Since 70% of small-dollar donations come via text,
and iPhones make up 60% of US mobile devices, the macro effect
could be over $500M in lost GOP revenue. […]
Unfortunately, K St and trade groups are asleep at the wheel.
Apple isn’t engaging. But we have only a few weeks left before the
public release. If we’re going to push back, it has to be now. We
have a very narrow window to fix this.
“Unknown Senders” isn’t spam. It’s for … unknown senders. Which these political texts are. I don’t know anyone who enjoys getting these texts in their primary timeline of messages. What the NRSC is asserting here is that they have a right to put political solicitations in your primary Messages view, and to have them appear as notifications, which is ridiculous.
Also, there’s no reason to believe that Republican candidates and groups will be more affected by this than Democratic ones. There’s no filtering by message content. It’s just a change to stop sending notifications for texts from unknown senders, and to put those messages in a separate timeline by default. People will check the Unknown Senders timeline occasionally too — all sorts of text messages from bots will go there, including some you want or need.
AMSTERDAM—German manufacturer Guntermann & Drunck GmbH (G&D) has announced that it will present a wide range of KVM and video processing solutions for broadcast and control room environments during IBC2025 between Sept. 12 to 15 at its booth 8.B51.
One of the key highlights of its live demos during the show will be the new VisionVS solution, which was developed in close collaboration with sister company VuWall.
This compact solution combines powerful KVM control with advanced video wall visualization, bridging the gap between two previously separate system worlds. Thanks to dual encoding technology, VisionVS simultaneously transmits two encrypted video streams – one in G&D’s proprietary bluedec™ format and a second in the VuWall format. The solution is particularly well-suited for mission-critical control rooms, where real-time transmission, low latency, and minimal hardware requirements are essential, the company explained.
Another highlight is the PersonalWorkplace-Controller, a flexible multi-viewing tool designed for broadcast environments. It allows users to display and control multiple video and computer signals on one or more screens within a customizable interface – ideal for control rooms, production studios, or master control rooms. The controller enhances clarity, improves workflows, and enables ergonomic operator station setups without compromising image quality or response time, the company reported.
During the show, G&D will also be demonstrating how its space-saving KVM and matrix solutions can be seamlessly integrated into OB vans and live studios. In environments where space is limited and maximum operational reliability is essential, these systems enable centralized, real-time control of technical resources. By relocating high-performance computers, heat and noise levels in the working environment are significantly reduced. At the same time, features such as multi-viewing, 4K resolution, redundant system structures, and encrypted signal transmission support the development of efficient, scalable production setups, the company said.
Whether in live production, broadcast control rooms, or OB vans, the demos will also show how its solution provide reliable access to distributed computer systems and are engineered to offer seamless control, high availability, and user-friendly integration in complex environments. By enabling centralized computer access and reducing heat, noise, and physical footprint at workstations, G&D helps create ergonomic, quiet, and fail-safe environments that are ideal for mission-critical applications, the company said.
More information about G&D’s solutions is available at www.gdsys.com.
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In clinical studies, the prevalence of cognitive impairments in MS is estimated to be between 54% and 65% [1]. These impairments tend to increase with worsening physical disability, disease duration, and a progressive course [6]. The cognitive domains most frequently affected in MS are speed of information processing, sustained attention, memory, and visuospatial perception [3]. Cognitive impairment significantly affects patients’ quality of life, social integration, and ability to work [18]. Levels of anxiety and depression can have a negative impact on patients’ cognitive performance, leading to poorer outcomes [8]. However, research has demonstrated that higher levels of cognitive reserve are linked to less cognitive impairment in pwMS [11].
The objective of this study was to investigate the relationship between depressive symptoms, CR, sustained attention, and semantic fluency in individuals with impairment. Our hypothesis was that CR predicts the relationship between depressive symptomatology and cognitive function. The main aim was to examine the role of CR as a moderator of the relationship between BDI, PASAT, and WLG.
The findings suggest a consistent association between increased depressive symptomatology and lower performance in sustained attention, and semantic fluency.
Depression affects over 20% of MS patients [19], leading to reduced quality of life, increased hospitalisation and mortality rates, and worse disability progression [20, 21]. Research has demonstrated a correlation between symptoms of depression in patients and a decline in attention and executive function, particularly in tasks that involve distractions [22, 23]. A subsequent study revealed that symptoms of depression are more closely linked to cognitive efficiency, specifically speed, rather than memory [24]. Several studies have shown that pwMS with depression perform worse on the PASAT than non-depressed MS patients and normal control participants [25, 26]. A meta-analysis of 10 studies on MS patients with depression also found a correlation between major depression and lower PASAT scores [27]. It has been widely demonstrated that high levels of depression are associated with worse performance on verbal semantic fluency tests [28].
However, the importance of CR as a predictor of cognitive functioning in persons with disabilities was reiterated [11]. Studies have indicated how CR predicts performance in tests of processing speed and memory [29]. However, it has also been shown the central role played by CR on all aspects of cognition such as executive functions, visuospatial processing and the various cognitive indices measured by the verbal fluency test [30].
To understand whether higher levels of cognitive reserve (CR) could influence the relationship between cognitive performance and depressive symptoms, we conducted a mediation analysis in our study. The analysis considered CR as a potential moderator in the model, based on the direct correlations observed. The results of the mediation analyses indicate that depressive symptoms did not have a direct negative impact on performance in working memory, sustained attention, and verbal fluency. Instead, cognitive reserve (CR) played a protective role in this relationship, resulting in better performance.
Previous research has investigated the relationship between cognitive reserve (CR) and depression. It has been suggested that CR may have a protective effect against the negative impact of increased neurological disability on an individual’s level of depression [31].
Additionally, the correlation between the CRIq score and cognitive performance suggests that patients with higher CRIq scores exhibit better information processing speed, as well as verbal and visuospatial memory performance, compared to those with lower CRIq scores [10]. Cognitive function is differentially protected by CR [32]. High CR predicts the preservation of functional brain connectivity despite grey matter atrophy and attenuates the detrimental effect of white matter alteration on information processing speed in MS patients [33]. In another MS study, high CR was found to selectively protect against the effect of peripheral grey matter atrophy on verbal memory [34].
Previous studies have examined the protective role of CR on cognitive function in patients without multiple sclerosis, but none have specifically focused on the moderating role of CR in the relationship between cognition and depression. Wight and colleagues [35] investigated the impact of education, post-school training, and occupation on cognitive function in a sample of older men living in the community. The study found that a higher level of education moderated the effect of depressive symptoms on cognition, but only when the symptoms were more severe. Bhalla et al. [36] found no moderating effect of education level on neuropsychological performance in a sample of depressed patients. In a study designed to examine the mediation of cognitive reserve in the relationship between cognitive performance and late-life depression, subjects with higher levels of education and/or higher reading scores showed greater declines in cognitive performance with increasing depressive symptoms than those with lower levels of education or reading scores in the reference sample [37]. In agreement with the literature, we also found better performance on cognitive tasks in our study in the presence of higher levels of cognitive reserve, which acts as a protective factor when higher levels of depressive symptoms are registered. While the effect size of -0.044 might be considered weak according to Cohen’s standards, it is important to note that even small effects can have substantial clinical implications for MS patients. The attenuation of cognitive reserve benefits by depressive symptoms highlights the need for integrated therapeutic approaches that address both cognitive and emotional health in MS care.
A few limitations must be considered when interpreting our results. The cross-sectional design, utilizing self-reported measures of CR and neuropsychiatric symptoms, was performed at a single center with a relatively small patient sample and a limited neuropsychological battery. It would be interesting to observe changes in cognitive profiles in larger cohorts over long-term follow-up with a more comprehensive neuropsychological evaluation (including the SDMT and other relevant tests), which could serve as a future goal for this preliminary cross-sectional study. Our findings are specific to the RR-MS population and may not be generalizable to patients with secondary progressive MS (SP-MS). The relatively low percentage of patients on DMTs highlights the variability in treatment practices and patient circumstances. Further research could explore the impact of cognitive reserve and depressive symptoms in other MS subtypes, including SPMS.
Additionally, recognizing the potential limitation of including only newly diagnosed PwMS, who may exhibit higher levels of depression or increased depressive symptoms, future research should compare this group with patients diagnosed for at least two years. This comparison will help clarify the impact of disease duration on depression and cognitive functions.
Finally, another limitation of this study is the absence of specific inclusion criteria for anxiety, fatigue, and sleep quality, despite their known effects on depression in people with disabilities. The sole reliance on the BDI is an additional limitation, as depression can be a secondary symptom in individuals with multiple sclerosis, complicating the relationship between depression and cognitive performance. Future studies should incorporate assessments of anxiety, fatigue, and sleep quality to provide a more comprehensive understanding of the behavioral factors influencing cognitive functions in individuals with multiple sclerosis.
