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  • Study Suggests Benefits of FDG PET/CT for Detecting Oligometastatic Breast Cancer

    Study Suggests Benefits of FDG PET/CT for Detecting Oligometastatic Breast Cancer

    For patients with locally advanced breast cancer, positron emission tomography/computed tomography (PET/CT) may provide enhanced detection of oligometastatic and polymetastatic disease.

    In a post-hoc analysis from a prospective multicenter trial, recently published in Radiology, researchers compared fluorodeoxyglucose (FDG) PET/CT to CT and bone scintigraphy (CTBS) in 369 women (mean age of 53) with locally advanced breast cancer.

    The study authors found a higher percentage of oligometastatic disease (OMD) detection with FDG PET/CT (11 percent) in comparison to CTBS (4 percent). There was also increased detection of polymetastatic disease (defined as > five distant metastases) with FDG PET/CT (13 percent) in contrast to CTBS (7 percent), according to the researchers.

    The above PET imaging revealed a left breast mass and metabolically active left axillary lymph nodes. Subsequent biopsy results confirmed invasive ductal carcinoma and axillary lymph node metastases. (Images courtesy of Radiology.)

    “These results suggest that if radical therapy with a potential long-term disease-free duration is planned for OMD, staging with CTBS alone is insufficient,” wrote lead study author Ur Metser, M.D., the division head of molecular imaging at the Joint Department of Medical Imaging for University Medical Imaging Toronto and the Women’s College Hospital Cancer Center in Toronto, and colleagues.

    For women with OMD and axillary lymph node metastases, the researchers noted that extra-axillary regional lymphadenopathy was detected with FDG PET/CT in 32 percent of patients in contrast to 13 percent with CTBS. While noting a lack of statistical significance with this finding, the study authors said this is a key consideration in the management of these patients.

    Three Key Takeaways

    1. Improved detection of metastatic disease. FDG PET/CT identified higher rates of oligometastatic (11 percent vs. 4 percent) and polymetastatic disease (13 percent vs. 7 percent) compared to CT and bone scintigraphy (CTBS) in locally advanced breast cancer.
    2. Impact on regional disease assessment. In women with OMD and axillary lymph node involvement, PET/CT detected more extra-axillary lymphadenopathy (32 percent vs. 13 percent) and extra-regional lymph node metastases (16 percent vs. 0 percent), potentially altering surgical and radiation planning.
    3. Greater detection of liver metastases. PET/CT demonstrated superior detection of liver metastases (32 percent vs. 13 percent) compared to CTBS, which may influence systemic therapy decisions.

    “This discrepancy in performance may influence treatment plans such as the extent of surgery or the radiation fields used to optimize local disease control,” added Metser and colleagues.

    The researchers also noted that FDG PET/CT detected higher percentages of extra-regional lymph node metastases (16 percent vs 0 percent) and liver metastases (32 percent vs. 13 percent) in comparison to CTBS in patients with OMD.

    (Editor’s note: For related content, see “PET/CT Shows Superior Results for Detecting Oligometastatic Breast Cancer in Comparison to CT,” “Researchers Show Higher Breast Cancer Upstaging Rate with 18F-FAPI PET/CT” and “Can Radioligand Therapy Have an Impact for Women with Breast Cancer?”)

    In regard to study limitations, the authors noted the exploratory nature of the research and acknowledged more robust data collection for the 18F-FDG PET/CT arm of the study in comparison to the CTBS cohort. The researchers also conceded a lack of data on long-term survival.

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  • How lithium went from 7Up to treatment for mental illness — and maybe Alzheimer’s – The Washington Post

    1. How lithium went from 7Up to treatment for mental illness — and maybe Alzheimer’s  The Washington Post
    2. Does lithium deficiency contribute to Alzheimer’s disease?  Nature
    3. Scientists say it may be possible to protect aging brains from Alzheimer’s with an old remedy — lithium  CNN
    4. Low lithium levels linked to Alzheimer’s  Chemistry World
    5. A new clue in Alzheimer’s could rewrite what we know about the disease  MDLinx

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  • What’s News in Markets: Apple’s Investment, Fannie and Freddie’s IPO, Crocs’ Misstep – What’s News – WSJ Podcasts – The Wall Street Journal

    1. What’s News in Markets: Apple’s Investment, Fannie and Freddie’s IPO, Crocs’ Misstep – What’s News – WSJ Podcasts  The Wall Street Journal
    2. Top Stock Market Highlights of the Week: Apple, CapitaLand Integrated Commercial Trust and Venture Corporation  sg.finance.yahoo.com
    3. The weekender: Bulls on a wire, AI euphoria, dovish hopes, and the market’s high-stakes balancing act  FXStreet
    4. Weekly Commentary: Anything But Normal Times  Seeking Alpha

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  • Canada increases funds needed to immigrate through rural pathways for PR by over 30%

    Canada increases funds needed to immigrate through rural pathways for PR by over 30%

    Immigration, Refugees and Citizenship Canada (IRCC) has increased the minimum settlement fund requirement for those immigrating through the Rural Community Immigration Pilot (RCIP) and the Francophone Community Immigration Pilot (FCIP).

    As of July 29, 2025, foreign nationals need a minimum of $2,544 more in settlement funds to immigrate through the RCIP or the FCIP.

    Assess your eligibility for the RCIP

    For a family of one, the minimum funds required to qualify for the RCIP or the FCIP increased from $7,963 to $10,507 on July 29 – a 31.94% increase.

    The RCIP and the FCIP are employer-driven pathways to permanent residence in Canada for those looking to settle in rural or francophone communities outside Quebec.

    How much money do I need to immigrate to Canada through the RCIP or the FCIP?

    The minimum amount of funds needed to immigrate through the RCIP or the FCIP depends on the size of your family.

    Both programs share the same settlement funds requirements.

    Number of family members Funds required (CAD) from July 29, 2025 Previous minimum fund requirement
    1 $10,507 $7,963
    2 $13,080 $9,692
    3 $16,080 $12,069
    4 $19,524 $15,056
    5 $22,143 $17,145
    6 $24,975 $19,015
    7 $27,806 $20,884
    For each additional member over 7 $2,831 $1,869

    How do I calculate the size of my family?

    Your family size includes

    • Yourself;
    • Your spouse or common-law partner; and
    • Dependent children (yours, your spouse or common law partner’s).

    You must include a spouse or common-law partner and dependent children even if they are Canadian citizens or permanent residents, and/or even if they are not coming to Canada with you.

    What does IRCC accept as proof of funds?

    Proof of funds can be any one of the following documents:

    • bank account statements;
    • bank drafts;
    • cheques; or
    • money orders.

    The money needs to be available when applying for the program, and when you are issued your permanent resident visa.

    About the RCIP and the FCIP

    The RCIP and the FCIP launched earlier this year to help employers in rural communities outside Quebec address labour shortages.

    To be eligible, a foreign national must have a job offer from a designated employer in the region. This offer must also be endorsed by a local economic development organization.

    Besides that, the foreign national has to meet certain eligibility criteria regarding education, work experience, language proficiency, and settlement funds. For the FCIP, foreign nationals need to prove French language proficiency.

    Those who meet all the eligibility criteria can apply directly to the federal government for PR.

    They are also eligible to apply for a work permit so they can start working for their employer while their PR application is being processed.

    There are 14 communities in total participating in the RCIP, while there are six communities participating in the FCIP. Each community has selected specific priority sectors and occupations based on their economic goals and workforce needs.

    Assess your eligibility for the RCIP

     


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  • Scientists make concerning discovery after analyzing melted glaciers: ‘An important future question’

    Scientists make concerning discovery after analyzing melted glaciers: ‘An important future question’

    For years, scientists have monitored the close relationship between rising carbon pollution and the melting of glaciers in the Arctic. According to a new study from researchers from the University of Florida and the University of Maryland, there may be a new dimension to the relationship that requires a closer look.

    What’s happening?

    As noted in the study, the team of researchers theorized that as glaciers melt and uncover land, the fresh sediments first trigger chemical reactions that actually help suppress greenhouse gases. The team explained its findings in an article published by Phys.org.

    Jonathan Martin, a professor of geological sciences at UF and the lead author of the study, revealed the core principle behind the research. “Our central hypothesis was that the transfer of greenhouse gases between landscapes and the atmosphere has changed since the Last Glacial Maximum about 15,000 years ago, as the landscapes are exposed following loss of continental ice sheets,” noted Martin.

    To test this theory, the team conducted field research at a “partially deglaciated watershed” in southwest Greenland. It was able to collect fresh glacial meltwater samples that contained low concentrations of reactive dissolved organic carbon. The researchers also pulled soil water that had been exposed to atmospheric conditions since the glacier first began retreating thousands of years ago.

    Why is this glacier study important?

    When newly crushed rock from melting glaciers breaks down through chemical reactions, it pulls carbon dioxide out of the air and stores it. This helps reduce the amount of greenhouse gases released into the atmosphere, at least temporarily.

    The team suggests that the meltwater was reacting with the fine, crushed rock left behind by the moving glaciers, which helped limit greenhouse gas release at first. But over thousands of years, as soil started to form on the exposed land, new chemical reactions began. These reactions in the soil started to produce methane, another powerful greenhouse gas.

    “These results imply that the loss of carbon dioxide from the atmosphere during deglaciation after the Last Glacial Maximum reduced the heat-trapping capacity of the atmosphere and provided a negative feedback on natural global warming associated with the transition out of an ice age,” explained Martin.

    The increase in global temperature has significantly impacted the environment by causing shifts in weather patterns, rising sea levels, disruptions to ecosystems, and other critical climate issues. These changes lead to more frequent and intense extreme weather events that threaten both wildlife and human populations.

    What’s being done about carbon emissions?

    The researchers believe that the exposed land ultimately produced more methane. Since methane is a strong greenhouse gas, this would make the atmosphere better at trapping heat, which in turn would lead to the continued increase of the global temperature.

    While researchers have detailed the impacts of gases like methane and carbon dioxide, Martin is now eyeing a new study that focuses more on nitrous oxide. Even though nitrous oxide represents just 6% of all gas emissions, its ability to trap heat in the atmosphere hasn’t gone unnoticed.

    “An important future question would be to evaluate how the relative magnitudes of production and loss of these three greenhouse gases relate to each other to regulate warming and cooling during the loss of glacial ice,” Martin added.

    Join our free newsletter for weekly updates on the latest innovations improving our lives and shaping our future, and don’t miss this cool list of easy ways to help yourself while helping the planet.

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  • Headless chicken monster: The deep sea cucumber with tubular feet for gobbling sediment

    Headless chicken monster: The deep sea cucumber with tubular feet for gobbling sediment

    QUICK FACTS

    Name: Headless chicken monster (Enypniastes eximia)

    Where it lives: The depths of the world’s oceans

    What it eats: Marine snow (organic matter that floats from the surface down to the seabed)

    If you happened upon this bizarre creature in the ocean, you could be forgiven for thinking someone had flung a chicken carcass into the sea and it was bobbing along on the current — hence its nickname, “the headless chicken monster.”

    But this strange creature is actually a sea cucumber that lives deep beneath the surface, generally below 1,600 feet (500 meters) and down to the seafloor.

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  • Japan used to be a tech giant. Why is it stuck with fax machines and ink stamps?

    Japan used to be a tech giant. Why is it stuck with fax machines and ink stamps?



    CNN
     — 

    When you think of Tokyo, you might think of neon-lit skyscrapers and its world-famous bullet train system, or films like “Akira” and “Ghost in the Shell” that depict a futuristic Japan filled with intelligent robots and holograms.

    But there’s a more mundane side of Japan that you won’t find anywhere in these cyberpunk films. It involves fax machines, floppy disks and personalized ink stamps – relics that have long died out in other advanced nations but have stubbornly persisted in Japan.

    For everyday residents, the lag in digital technology and the ensuing bureaucracy is at best inconvenient, and at worst makes you want to tear your hair out.

    “Japanese banks are portals to hell,” one Facebook user wrote in a local expat group. A commenter joked sarcastically: “Maybe sending a fax would help.”

    The scale of the problem became terrifyingly clear during the Covid-19 pandemic, as the Japanese government struggled to respond to a nationwide crisis with clumsy digital tools.

    In the years since, they’ve launched a dedicated effort to close that gap, including a newly created Digital Agency and a host of new initiatives. But they’re arriving to the tech race decades late – 36 years after the arrival of the World Wide Web, and more than half a century after the first ever email was sent.

    Now as the country races to transform itself, the question remains: What took them so long, and can they still catch up?

    It wasn’t always this way. Japan was the object of global admiration in the 1970s and ‘80s, when companies like Sony, Toyota, Panasonic and Nintendo became household names. Japan brought the world beloved devices like the Walkman, and games like Donkey Kong and Mario Bros.

    But that changed by the turn of the century with the rise of computers and the internet.

    While the world was shifting to software-driven economies, “Japan, with its strengths in hardware, was slow to adapt to software and services,” said Daisuke Kawai, director of the University of Tokyo’s Economic Security and Policy Innovation Program.

    A range of factors exacerbated the problem, he said. Japan didn’t invest enough in information and communications technology, and as its electronics industry shrank, Japanese engineers flocked to foreign companies.

    That left a government with low digital literacy and a lack of skilled tech workers. Over time, different ministries and agencies adopted their own patchwork IT strategies, but there was never a unified government push – meaning public services never properly modernized and remained reliant on paper documents and hand-carved, personalized seals called hanko that are used for identity verification.

    There were cultural factors, too.

    “Japanese companies are known for their risk-averse culture, seniority-based … hierarchical system, and a slow, consensus-driven decision-making process – all of which hampered innovation,” Kawai said.

    And thanks to Japan’s plummeting birthrate, it has far more old people than young people. This outsized elderly proportion meant a wider distrust of new technologies, wariness of digital fraud, a preference for traditional methods like the hanko, and “relatively little demand or pressure for digital services,” Kawai said.

    Numerous hanko name stamps are displayed at a hanko shop in Toshima Ward, Tokyo.

    That apathy was widespread, said Jonathan Coopersmith, professor emeritus of history at Texas A&M University. Small businesses and individuals didn’t feel compelled to switch from fax machines to computers: Why buy expensive new machinery and learn how to use it, when fax worked fine and everybody in Japan used it anyway?

    Larger corporations and institutions like banks or hospitals found a potential switch too disruptive to daily services. “The bigger you are, the harder it is to change, especially software,” said Coopersmith, who wrote about Japan’s relationship with the fax machine in a 2015 book about the device.

    It also posed a legal headache. Any new technology requires new laws – for instance, how electric scooters prompted new road regulations, or how countries worldwide are now trying to legislate against deepfakes and AI copyright after the AI boom. Digitizing Japan would have required changing thousands of regulations, Coopersmith estimates – and lawmakers simply had no incentive to do so. After all, it’s not like digitization is a key issue driving votes in elections.

    He summed it up: “Why do I want to become part of the digital world if I don’t need to?”

    The pandemic push

    The result was that for decades, Japan remained stuck with old tech even as it progressed in other ways – creating the ultimate contradiction.

    Japan has world-class robotics and aerospace industries, and features of day-to-day life that tend to awe foreign tourists, like safe and clean public spaces, ubiquitous vending machines and convenience stores, widely accessible public transit and a comprehensive bullet train system.

    Its digital failings look even more stark by comparison.

    In 2018, Japan’s then cybersecurity minister sparked outrage and disbelief when he claimed he’d never used a computer since his secretaries did “that kind of thing” – before walking back his remarks a few days later.

    And it wasn’t until 2019 that the last company in Japan still operating pagers finally halted services – decades after the personal messaging device was rendered obsolete by cell phones.

    The prevalence of old technology also created endless bureaucracy. Opening a bank account or registering for housing might require a hanko seal, along with documents of personal information you have to visit a local council to request in person, said Kawai.

    A hanko is stamped on a banking document in an arranged photograph taken in Tokyo, Japan.

    In the end, it took a global pandemic to finally force change. Japan’s technological gap became evident as national and local authorities became overwhelmed, without the digital tools to streamline their processes.

    It was only in May 2020, months after the virus began running rampant globally, that Japan’s health ministry launched an online portal for hospitals to report cases instead of relying on handwritten faxes, phone calls or emails.

    And even then, hiccups persisted. A contact tracing app had a months-long system error that failed to notify people of possible exposure, reported public broadcaster NHK. Adjusting to remote work and school was tough, as many had never used file-sharing services or video tools like Zoom.

    In one mind-boggling case in 2022, a Japanese town accidentally wired the entirety of its Covid relief fund – about 46.3 million yen ($322,000) – to just one man’s bank account. The confusion stemmed from the bank being given both a floppy disk of information and a paper request form – but by the time authorities realized their error, the man had already gambled away most of the funds, according to NHK.

    For anyone under 35, a floppy disk is a magnetic memory strip encased in plastic that is physically inserted into a computer. Each one typically stores up to 1.44MB of data – less than an average-resolution photo on your iPhone.

    The situation got so bad that at one point, Takuya Hirai – who in 2021 was appointed to the newly created role of Minister of Digital Transformation – described the country’s handling of the pandemic as a “digital defeat.”

    Thus, the Digital Agency was born – a department tasked with bringing Japan up to speed, born from a “combination of fear and opportunity,” said Coopersmith.

    Created in 2021, it launched a series of initiatives including rolling out a smart version of Japan’s social security card and pushing for more cloud-based infrastructure.

    Last July, the Digital Agency finally declared victory in its “war on floppy disks,” eliminating the disks across all government systems – a mammoth effort that required scrapping more than 1,000 regulations governing their use.

    But there were growing pains, too. At one point, the government asked the public for their thoughts about the metaverse – through a convoluted system that required downloading an Excel spreadsheet, filling out your details, and emailing the document back to the ministry, local media reported.

    After the move garnered scorn and disbelief on social media, then Digital Minister Taro Kono wrote on Twitter: “The (ministry) will respond properly using an (online) form from now on.”

    With the government firmly forging forward, companies hastened to follow, many hiring external contractors and consultants to help overhaul their systems, said Kawai.

    Masahiro Goto is one such consultant. As part of the Nomura Research Institute’s (NRI) digital transformation team, he has helped large Japanese companies across all industries adapt to the digital world – from designing new business models to adopting new internal systems.

    These clients are often “eager to move forward, but they’re unsure how to go about it,” he told CNN. “Many are still using old systems that require a lot of maintenance, or systems that are approaching end-of-service life. In many cases, that’s when they reach out to us for help.”

    The NRI consultants are in high demand – the number of companies reaching out for their services “has definitely been rising year by year,” especially in the last five years, Goto said. And for good reason: for years, Japanese companies outsourced their IT needs, meaning they now lack the in-house skills to fully digitize.

    A sign for cashless payments outside a shop in the trendy Omotesando district of Tokyo.

    “Fundamentally, they want to make their operations more efficient, and I believe they want to actively adopt digital technologies as a means of survival,” he said. “After all, Japan’s population is going to continue to decline, so improving productivity is essential.”

    There may be resistance in certain pockets – the Digital Agency’s plan to eliminate fax machines within the government received 400 formal objections from different ministries in 2021, according to local media.

    Things like the hanko seal – which are rooted in tradition and custom, and which some parents gift to their children when they come of age – may be harder to phase out given their cultural significance.

    The pace of progress also depends on how willing the Digital Agency is to push regulatory reform, and how much lawmakers will prioritize digitization in creating future budgets, Kawai said. There’s also the fact Japan is playing catch-up with moving goalposts, as new technologies surge forward in other parts of the world.

    “This is going to be an ongoing challenge because the digital technologies of 2025 are going to be different from the ones of 2030, 2035,” said Coopersmith.

    But experts are optimistic. Kawai estimates at this rate, Japan could catch up with some Western peers in five to 10 years.

    And finally, there’s a public hunger for it, with more and more businesses accepting cashless payments and rolling out new online services.

    “People are generally eager to digitize for sure,” said Kawai. “I’m sure that young people, or the general public, prefer to digitize as fast as possible.”

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  • ‘Olympus’ the 4-legged robot could help astronauts explore Mars someday (video)

    ‘Olympus’ the 4-legged robot could help astronauts explore Mars someday (video)

    A four-legged robot tested under simulated Martian gravity jumps from wall to wall in a new video, demonstrating how future explorers could navigate terrain too challenging for today’s rovers.

    Designed for use in low-gravity environments like on the moon and Mars, the four-legged robot, named Olympus, uses “double” limbs with jointed knees and paw-like feet for agile movement. At the European Space Agency’s (ESA) Orbital Robotics Interactive Test (ORBIT) facility in the Netherlands, the robot recently showcased its ability to stabilize, jump and reorient itself under simulated microgravity conditions.

    In reduced gravity, like that of Mars, which is about 38% of Earth’s, the robot’s jumping ability could be a powerful advantage, enabling it to vault over obstacles that would stop traditional wheeled rovers in their tracks. Robots like Olympus could also access underground features such as lava tubes or caverns, which are too risky for drones or flying probes to explore, Jørgen Anker Olsen, who developed and built the robot, explained in a statement from ESA.

    The team’s four-legged robot design. (Image credit: ESA/J. A. Olsen)

    During the tests, Olympus was mounted upside-down on one of ORBIT’s floating platforms, which glides on a thin cushion of air across an ultra-flat floor without any friction, reproducing a state of weightless free-floating in two dimensions, similar to how pucks float on an air hockey table. This allowed the team to test the robot’s full range of leg motion.

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  • Farnham youth choir to perform at BBC Proms

    Farnham youth choir to perform at BBC Proms

    A youth choir from Surrey is to take part in a sold-out performance at the Royal Albert Hall at the BBC Proms.

    Farnham Youth Choir will perform with the National Youth Orchestra during a rendition of Neptune in Holst’s famous The Planets in London on Saturday.

    A total of 30 singers, aged between 13 to 21-years-old, will be taking part in the concert.

    Patrick Barrett, the group’s artistic director, said: “I’m incredibly proud of our young singers, whose hard work and dedication made this invitation possible.”

    He added: “For our small-town choir to be invited to such a prestigious, globally recognised event is a tremendous honour.”

    The performance follows the choir competing at the 2024 World Choir Games in New Zealand, where they won two gold medals.

    Its three choirs rehearse with a dedicated team of professional musicians every Wednesday during term time in Farnham.

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  • Elvis-inspired teacher fights Roma prejudice with music and heart | Arts and Culture News

    Elvis-inspired teacher fights Roma prejudice with music and heart | Arts and Culture News

    Tudor Lakatos challenges Roma discrimination through Elvis Presley’s musical legacy.

    Sporting a rhinestone shirt, oversized sunglasses and a classic 1950s quiff, Lakatos captivates audiences across Romania with his distinctive renditions of songs like Blue Suede Shoes.

    Rather than being an impersonator, Lakatos harnesses Elvis’s universal appeal to dismantle stereotypes about Roma people and inspire Roma youth.

    “I never wanted to get on stage, I did not think about it,” Lakatos, 58, said after a recent gig at a restaurant in the capital, Bucharest. “I only wanted one thing – to make friends with Romanians, to stop being called a Gypsy,” he added, using an often derided term for people belonging to the Roma ethnic group.

    The Roma, with South Asian origins, have endured centuries of persecution throughout Eastern Europe and continue to face poverty, unemployment and prejudice. In Romania, they represent approximately seven percent of the population, with one-fifth reporting discrimination experiences in the past year, according to European Union data.

    Lakatos began his mission in the early 1980s as an art student during Nicolae Ceausescu’s communist regime. When anti-Roma sentiment was widespread, he discovered that Elvis’s music created connections with ethnic Romanian students while simultaneously symbolising resistance against government oppression.

    Now, 40 years later, his audience has expanded. As a teacher for 25 years, Lakatos uses music to show his students they can aspire beyond the limited opportunities of their northwestern Romanian village.

    “The adjective Gypsy is used everywhere as a substitute for insult,” Lakatos said. “We older people have gotten used to it, we can swallow it, we grew up with it. I have said many times, ‘Call us what you want, dinosaur and brontosaurus, but at least join hands with us to educate the next generation.’”

    Despite his teaching career, Lakatos continues performing throughout Romania at various venues.

    The eclectic mix of languages can sometimes lead to surprises because there is not always a literal translation for Elvis’s 1950s American English.

    For example, “Don’t step on my blue suede shoes” does not make sense to many of the children he teaches because they are so poor, Lakatos said.

    In his version, the lyric Elvis made famous becomes simply “Don’t step on my bare feet.”

    It is a message that Elvis – born in a two-room house in Tupelo, Mississippi, during the Great Depression – probably would have understood.

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