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  • Princess Kate ‘Has Good Days and Bad Days’ As She Continues to Recover From Cancer Battle: Source

    Princess Kate ‘Has Good Days and Bad Days’ As She Continues to Recover From Cancer Battle: Source

    The royals were out in force at Royal Ascot in mid June, days of world-class horse racing, with spectators in top hats and whimsical fascinators sipping on Pimm’s Cup and riding in open carriages to the course in Berkshire, England, about 25 miles west of London. Kate Middleton, the Princess of Wales, of course, was not among the well-dressed crowd.

    Minutes after Buckingham Palace’s official carriage list was released — indicating that Kate and her husband, Prince William, would arrive in a horse-drawn landau — Kensington Palace announced the 43-year-old would not attend. After initially claiming the list was sent in error, a  royal source told ABC News that Kate was “disappointed” to miss the social event, but “has to find the right balance as she fully returns to public-facing duties.”

    It’s a stark reminder that the princess, who revealed in March 2024 that she was diagnosed with an undisclosed form of cancer, is still not completely well. And once again, she is torn between her duties as the future queen and her need to take care of her health. “It’s a delicate balance whereby Kate is striving to care for herself and still carry out royal duties,” an insider tells Star. “Kate has good days and bad days, that’s just part of her recovery.”

    Finding Meaning

    The princess’ illness, which involved abdominal surgery in January 2024 as well as chemotherapy, has made her more reflective of how she spends her time. In a video last June, the mom of George, 11, Charlotte, 10, and 6-year-old Louis explained that on bad days she felt “weak” and “tired,” adding, “But on the good days, when you feel stronger, you want to make the most of feeling well.”

    MEGA

    While she skipped Ascot, Kate made sure to fulfill a less glitzy obligation, penning a June 20 letter to draw attention to the work of children’s hospices. Naming two that she is patron of, Kate wrote of the privilege of seeing them “lifting spirits through laughter, fun and play, as well as listening, holding, caring and sharing. They support children and families through life, death and beyond.”

    Her own brush with mortality has left Kate even more devoted to her young family. “As harrowing as the illness was on Kate, it did teach her a lot about priorities,” notes the insider. “Spending time with her kids, as well as William of course, is her biggest priority bar none.” She’s also determined not to worry her children. “She keeps them up to speed on her health,” adds the insider, “reassuring the kids that she’s getting better and better as time goes on.”

    Future Queen

    Kate’s health setback comes as her father-in-law, King Charles III, is also battling cancer, reportedly undergoing weekly treatments. The 76-year-old’s declining health has no doubt put pressure on Kate and future king William, 43, as they face the prospect of ascending to the throne far sooner than they expected. “Kate is acutely aware that she’ll be queen one day and is mindful that she has to prepare for that eventuality,” explains the insider.

    <span class="wp-caption-text">WireImage</span>

    WireImage

    At the same time, Charles — who attended Royal Ascot with his wife, Queen Camilla, 77 — has barely slowed his busy schedule. “Seeing King Charles carrying on with his full workload even whilst he’s so poorly is something Kate finds admirable,” says the insider. “But at the same time there’s probably a lingering worry that she may look like she’s slacking by comparison.”

    Not that the king is pointing fingers. Throughout their illnesses, Charles and Kate have grown close, reveals the insider. “They’ve bonded enormously. There’s so much mutual respect between the two, and as awful as it’s been, the one positive is that it’s brought them so much closer together.”

    <span class="wp-caption-text">MEGA</span>

    MEGA

    William, too, has discovered a new appreciation for the woman he met as an undergrad at Scotland’s University of St Andrews and wed in 2011. “He’s quick to quell any anxiety or jitters she may have,” says the source. “He often goes out of his way to reassure Kate that by taking a step back from time to time she’s by no means neglecting her royal duties.”

    As one of the most popular royals in the family, Kate is still learning how to put herself first. “The people love her, the royal family appreciate her,” says the insider. “ Still, she’s a perfectionist at heart, always striving to contribute and fulfill her role to the best of her abilities.

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  • FDA Grants Accelerated Approval to Sunvozertinib for Metastatic NSCLC With EGFR Exon 20 Insertion Mutations

    FDA Grants Accelerated Approval to Sunvozertinib for Metastatic NSCLC With EGFR Exon 20 Insertion Mutations

    The FDA has granted accelerated approval to sunvozertinib (Zegfrovy) for the treatment of adult patients with locally advanced or metastatic non–small cell lung cancer (NSCLC) harboring EGFR exon 20 insertion mutations, as detected by an FDA-approved test, whose disease has progressed on or following platinum-based chemotherapy.1

    The efficacy of the agent was examined in the multinational, open-label WU-KONG1b trial (NCT03974022). Data showed that sunvozertinib elicited an objective response rate of 46% (95% CI, 35%-57%), with a duration of response of 11.1 months (95% CI, 8.2-not evaluable).

    About the Trial

    WU-KONG1 Part B enrolled patients with locally advanced or metastatic NSCLC with EGFR exon 20 insertion mutations confirmed in tumor tissue.2 Patients needed to have an ECOG performance status of 0 or 1 and have received prior treatment with platinum-based chemotherapy.

    Patients were randomly assigned 1:1 to receive sunvozertinib at 200 mg daily or 300 mg daily. At the interim analysis, 111 patients went on to receive continuous dosing of the agent at 300 mg daily until trial discontinuation criteria were met.

    Independent review committee (IRC)–assessed ORR served as the trial’s primary end point. IRC-assessed duration of response (DOR) was a key secondary end point. Other secondary end points included investigator-assessed ORR and DOR.

    Safety Spotlight

    The most common grade 3 or higher treatment-related adverse effects (TRAEs) observed with the agent at the 300-mg dose included diarrhea (17.1%), increased blood creatinine phosphokinase levels (10.8%), anemia (3.6%), rash (3.6%), increased lipase levels (3.6%), decreased neutrophil counts (2.7%), hypokalemia (2.7%), decreased appetite (2.7%), and asthenia (2.7%). TRAEs led to dose reduction and treatment discontinuation in 36.0% and 6.3% of patients, respectively. Investigators noted that most of the common TRAEs were grade 1 or 2 in severity and clinically manageable. No TRAEs led to fatal outcomes.

    What Came Before

    Previously, in April 2024, the FDA granted breakthrough therapy designation to sunvozertinib for patients with treatment-naive NSCLC harboring an EGFR exon 20 insertion mutation.3

    References

    1. FDA grants accelerated approval to sunvozertinib for metastatic non-small cell lung cancer with EGFR exon 20 insertion mutations. FDA. July 2, 2025. Accessed July 2, 2025. https://www.fda.gov/drugs/resources-information-approved-drugs/fda-grants-accelerated-approval-sunvozertinib-metastatic-non-small-cell-lung-cancer-egfr-exon-20
    2. Yang J CH, Doucet L, Wang M, et al. A multinational pivotal study of sunvozertinib in platinum pretreated non-small cell lung cancer with EGFR exon 20 insertion mutations: primary analysis of WU-KONG1 study. J Clin Oncol. 2024;42(suppl 16)8513. doi:10.1200/JCO.2024.42.16_suppl.8513
    3. FDA grants breakthrough therapy designation to sunvozertinib for the first-line treatment of patients with advanced non-small cell lung cancer harboring EGFR exon 20 insertion mutations. News Release. Dizal Pharma. April 7, 2024. Accessed July 2, 2025. https://www.dizalpharma.com/news/detail?id=70&search=&currentPage=1

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  • Fitch Affirms Bunge at 'BBB+'/Stable; Upgrades and Withdraws Viterra's IDR – Fitch Ratings

    1. Fitch Affirms Bunge at ‘BBB+’/Stable; Upgrades and Withdraws Viterra’s IDR  Fitch Ratings
    2. Bunge Global upgraded to A- by S&P following Viterra merger  Investing.com
    3. Glencore announces $1 billion share buyback  Global Banking | Finance | Review
    4. Bunge and Viterra Complete Merger to Create Premier Global Agribusiness Solutions Company  Yahoo Finance
    5. Bunge completes $8.2B Viterra acquisition, creating global agriculture powerhouse  The Business Journals

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  • Blizzard is winding down support for its Warcraft mobile game

    Blizzard is winding down support for its Warcraft mobile game

    Microsoft’s layoff of roughly 9,000 employees is continuing to have downstream effects at the company’s subsidiaries. Aftermath reports that as many as 100 developers at Blizzard have been impacted, and as a result the studio is winding down development on its mobile tower defense game Warcraft Rumble.

    In an announcement, Blizzard wrote that while the game will not be abandoned entirely, the company will cease development on any new content. “Moving forward, we’ll continue supporting Rumble with updates focused on regular, systemic in-game events and bug fixes, but no new content. ”

    Blizzard continued, saying Rumble, “struggled to find its footing relative to our ambition for its long-term success.” And while its developers worked to respond to player feedback that, “ultimately wasn’t enough to put the game on a path to sustainability.”

    Warcraft Rumble was the first mobile focused game in the Warcraft Universe. It launched in 2023 after nine years in development and was originally one of two mobile games Blizzard was working on, the other being Blizzard’s take on Pokémon Go. That game was never officially announced by Blizzard and cancelled sometime in 2022. Warcraft Rumble joins a handful of other Blizzard games in development stasis along with Starcraft II and Heroes of the Storm.

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  • Webb and Chandra Image of Bullet Cluster Maps Invisible Dark Matter

    Webb and Chandra Image of Bullet Cluster Maps Invisible Dark Matter

    ‘This is the central region of the Bullet Cluster, which is made up of two massive galaxy clusters. The vast number of galaxies and foreground stars in the image were captured by NASA’s James Webb Space Telescope in near-infrared light. Glowing, hot X-rays captured by NASA’s Chandra X-ray Observatory appear in pink. The blue represents the dark matter, which was precisely mapped by researchers with Webb’s detailed imaging. Normally, gas, dust, stars, and dark matter are combined into galaxies, even when they are gravitationally bound within larger groups known as galaxy clusters. The Bullet Cluster is unusual in that the intracluster gas and dark matter are separated, offering further evidence in support of dark matter. (See the defined galaxy clusters within the dashed circle.’ | Credit: NASA, ESA, CSA, STScI, CXC; Science: James Jee (Yonsei University/UC Davis), Sangjun Cha (Yonsei University), Kyle Finner (IPAC at Caltech)

    NASA’s James Webb Space Telescope (JWST) and Chandra X-ray Observatory combined their efforts to look at the Bullet Cluster in a new way, enabling scientists to precisely map the cluster’s dark matter.

    Webb’s near-infrared imaging capabilities enabled astronomers to capture the highest detailed images yet of the Bullet Cluster, which comprises a pair of massive galaxy clusters. With Webb’s highly sensitive cameras, researchers can see fainter, more distant galaxies in the Bullet Cluster than ever before.

    “With Webb’s observations, we carefully measured the mass of the Bullet Cluster with the largest lensing dataset to date, from the galaxy clusters’ cores all the way out to their outskirts,” says Sangjun Cha, the lead author on a new research paper published this week in The Astrophysical Journal Letters. Cha is a PhD student at Yonsei University in Seoul, South Korea.

    “Webb’s images dramatically improve what we can measure in this scene — including pinpointing the position of invisible particles known as dark matter,” adds Kyle Finner, a co-author of the new research paper and an assistant scientist at IPAC at Caltech in Pasadena, California.

    As NASA explains, “all galaxies are made up of stars, gas, dust, and dark matter, which are bound together by gravity.” The Bullet Cluster is not just a galaxy, but a grouping of two “very massive collections of galaxies.”

    The galaxy clusters, which are massive and therefore have powerful gravitational forces, can act as gravitational lenses that significantly magnify the light of background galaxies. The amount of gravitational lensing, when compared against the amount of visible mass in a cluster, enables scientists to infer the distribution of invisible dark matter.

    A deep space image showing countless distant galaxies of various shapes and sizes, scattered against a dark background with several bright stars featuring diffraction spikes.
    Bullet Cluster — NIRCam image

    “Gravitational lensing allows us to infer the distribution of dark matter,” says co-author James Jee, professor at Yonsei University and research associate at UC Davis in California.

    It is helpful to think about gravitational lensing and dark matter using a metaphor of a pond filled with crystal-clear water and pebbles, Jee says.

    “You cannot see the water unless there is wind, which causes ripples,” the scientist explains. “Those ripples distort the shapes of the pebbles below, causing the water to act like a lens.” This same phenomenon occurs in space, where the water represents dark matter, and the pebbles in the example represent background galaxies.

    With Webb’s imaging capabilities, it is much easier to see and measure the galaxies, including the background ones, meaning it is possible to weigh both visible and invisible matter (dark matter) in the galaxy clusters. The researchers also mapped and measured the collective light emitted by intracluster stars. These are stars that are no longer bound to an individual galaxy.

    “We confirmed that the intracluster light can be a reliable tracer of dark matter, even in a highly dynamic environment like the Bullet Cluster,” Cha says. If intracluster stars are not bound to galaxies, and instead are bound to dark matter, scientists could learn much more about dark matter and its distribution.

    Image credits: NASA, ESA, CSA, STScI, CXC; Science: James Jee (Yonsei University/UC Davis), Sangjun Cha (Yonsei University), Kyle Finner (IPAC at Caltech). Video credits: NASA, ESA, CSA, Joseph DePasquale (STScI)

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  • Over Decades, A Healthy Lifestyle Outperforms Metformin in Preventing Onset of Type 2 Diabetes

    Over Decades, A Healthy Lifestyle Outperforms Metformin in Preventing Onset of Type 2 Diabetes

    In the early 2000s the U.S. Diabetes Prevention Program (DPP), a large randomized clinical trial, showed that intensive lifestyle modification was better than a medication called metformin at preventing at-risk patients from developing Type 2 diabetes.

    In a newly completed follow-up study, a team of researchers including Vallabh “Raj” Shah, professor emeritus in The University of New Mexico Departments of Internal Medicine and Biochemistry & Molecular Biology at the School of Medicine, found that the health benefits from the lifestyle intervention persisted more than 20 years later.

     

    Within three years, they had to stop the study because lifestyle was better than metformin. That means lifestyle, which everybody is banking on, is more effective — that is the news.

     

    -Vallabh “Raj” Shah, PhD, Professor Emeritus, The University of New Mexico Departments of Internal Medicine and Biochemistry & Molecular Biology at the School of Medicine

    In a paper published in The Lancet Diabetes & Endocrinology, they reported that the greatest results from both interventions were seen in the first few years of the study, and they were durable, Shah said. “The data suggests that those people who didn’t get diabetes also didn’t get diabetes after 22 years,” he said.

    The DPP was launched in 1996 to compare the benefits of metformin – then newly approved by the FDA to treat Type 2 diabetes – and a lifestyle modification regimen that included exercise and a healthy diet. The study enrolled 3,234 patients with prediabetes at 30 institutions in 22 states.

    2025_06_11_Raj_Shah-4

    Vallabh “Raj” Shah, PhD. Photo Credit: Jett Loe

    The intensive lifestyle intervention reduced the development of diabetes by 24%, and metformin reduced diabetes development by 17%, according to the new study. The DPP had previously found that after the first three years of study, the lifestyle intervention of moderate weight loss and increased physical activity reduced the onset of Type 2 diabetes by 58% compared with a placebo medicine, while metformin reduced development of diabetes by 31%.

    Compared with the original placebo group, the median time without diabetes was extended by three-and-a-half years in the lifestyle group and two-and-a-half years in the metformin group.

    “Within three years, they had to stop the study because lifestyle was better than metformin,” Shah said. “That means lifestyle, which everybody is banking on, is more effective – that is the news.”

    But because a wealth of health and biological data had already been collected for patients participating in the project, the DPP was repurposed into the DPP Outcomes Study (DPPOS), enabling researchers to follow their health outcomes in multiple domains over a period of decades, he said.

    2025_06_11_Raj_Shah-3

    Vallabh “Raj” Shah, PhD. Photo Credit: Jett Loe

    Shah has contributed to kidney disease research for more than three decades, conducting multiple studies at Zuni Pueblo and other American Indian communities in western New Mexico. He has also overseen the participation of the American Indian cohort enrolled in the DPPOS. Meanwhile, David Schade, MD, chief of the Division of Endocrinology in the UNM School of Medicine, recruited New Mexico participants in the study.

    More recently, he said, DPPOS researchers have taken advantage of their large, well-documented cohort to repurpose the study to focus on diseases associated with aging, such as cancer and dementia, Shah said.

    Banner Photo: Vallabh “Raj” Shah, PhD. Photo Credit: Jett Loe

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  • Gaza: Access to key water facility in Khan Younis disrupted, UN reports

    Gaza: Access to key water facility in Khan Younis disrupted, UN reports

    According to the UN Office for the Coordination of Humanitarian Affairs (OCHA), Israeli authorities issued displacement orders overnight for two neighbourhoods in Khan Younis, where up to 80,000 people had been living.

    The Al Satar reservoir – a critical hub for distributing piped water from Israel – has become inaccessible as a result.

    Grave warnings

    “Any damage to the reservoir could lead to a collapse of the city’s main distribution of the water system, with grave humanitarian consequences,” UN spokesperson Stéphane Dujarric told reporters at a daily news briefing in New York.

    Al Satar’s disruption comes as Gaza’s infrastructure buckles under relentless displacement, strained services and critical shortages of fuel and supplies.

    Approximately 85 per cent of Gaza’s territory is currently either under displacement orders or located within military zones – severely hampering people’s access to essential aid and the ability of humanitarians to reach those in need, OCHA reported.

    Displacement continues

    Since the collapse of a temporary ceasefire in March, nearly 714,000 Palestinians have been displaced again, including 29,000 in the 24 hours between Sunday and Monday. Existing shelters are overwhelmed, and aid partners report deteriorating health conditions driven by insufficient water, sanitation and hygiene services.

    Health teams report that rates of acute watery diarrhoea have reached 39 per cent among patients receiving health consultations. Khan Younis and Gaza governorates are hardest hit, with densely overcrowded shelters and little access to clean water exacerbating the spread of disease.

    Adding to the crisis, no shelter materials have entered Gaza in over four months, despite the hundreds of thousands of newly displaced people. UN partners reported that in 97 per cent of surveyed sites, displaced families are sleeping in the open, exposed to heat, disease and trauma.

    Fuel shortages

    Meanwhile, fuel shortages are jeopardising the humanitarian response. A shipment of diesel intended for northern Gaza was denied on Wednesday by Israeli authorities, just a day after a successful but limited delivery to Al Shifa Hospital in Gaza City.

    If the fuel crisis is not urgently addressed, Mr. Dujarric warned that relief efforts could grind to a halt.

    “If the fuel crisis isn’t addressed soon, humanitarian responders could be left without the systems and the tools that are necessary to operate safely, manage logistics and distribute humanitarian assistance,” he said.

    “This would obviously endanger aid workers and escalate an already dire humanitarian crisis.”

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  • Amazon’s Prime exclusive Echo Frames deal comes with an Echo Spot (and it’s still cheaper than Meta Ray-Bans)

    Amazon’s Prime exclusive Echo Frames deal comes with an Echo Spot (and it’s still cheaper than Meta Ray-Bans)

    June Wan/ZDNET

    Smart glasses are among the latest and most interesting tech developments. They suit an audience of tech enthusiasts and photographers and can even help bridge the gap for those with visual impairment. Amazon took its stab at them, introducing the Echo Frames in 2019 and updating them periodically since. 

    Also: The best Prime Day tech deals live now 

    Luckily, Amazon is offering an early Prime exclusive bundle deal — even days ahead of Prime Day, which starts on July 8. For only $130, you can get the third generation of Echo Frames in any color, plus an Echo Spot. That’s an excellent offer, considering Amazon is selling the Echo Frames alone for $270. Amazon is also offering another Prime exclusive bundle at a discount. The Echo Frames and Echo Show 8 are on sale together for $240. 

    A good way to describe the Echo Frames is as headphones with a little more utility. Besides wearing them for the aesthetic, the glasses offer many different features that substitute devices like your headphones or Bluetooth speaker and your Alexa devices.

    Also: These smart glasses beat the Meta Ray-Bans in a few key ways

    The glasses are still extremely capable. An Alexa assistant is available, and you can use it to listen to books, music, and podcasts, as the open-ear speakers direct sound to your ear while minimizing it for others around you. 

    These frames are a good entry point into smart glasses, as the price is fair. However, the features are minimal compared to their competitors. For instance, the Echo Frames do not have a built-in camera. 

    Also: The best Prime Day Echo device deals 

    You can make calls, though, which would be a selling point for business professionals or those on the go. The glasses can also be used for controlling Alexa devices, like the Echo Spot, Amazon’s Alexa-enabled alarm clock, which comes with this bundle. 

    Also: I took my Ray-Ban Meta smart glasses fly fishing, and they beat GoPro in several surprising ways

    ZDNET expert Kerry Wan tested the Echo Frames and thought they were very convenient for daily use, especially for tasks like calling or listening to music while walking.

    Amazon Echo Frames 3rd Gen

    A closer look at the Amazon Echo Frames 3rd Gen. 

    June Wan/ZDNET

    “Besides the smart features, I’ve also enjoyed listening to podcasts and making calls during my evening walks. Perhaps it’s the ability to listen to my on-device audio while staying aware of my surroundings, or the fact that the speakers on the Echo Frames favor the mid and high frequencies more than the bassy, engulfing lows,” he said. 

    The Echo Frames are a great entry point into the world of smart glasses, and right now they’re much cheaper than a pair of Meta Ray-Bans. 

    Looking for the next best product? Get expert reviews and editor favorites with ZDNET Recommends.

    How I rated this deal 

    With this deal you’re getting the Echo Frames at a significant discount, plus a free Echo Spot. We have factored in the 63% bundle discount, and have given this deal a 5/5 Editor’s deal rating. Not only is this a newer product with a price slash, but it also includes a compatible Alexa device. This deal would be great for those who want to try out new variations of tech without breaking the bank. 

    Deals are subject to sell out or expire anytime, though ZDNET remains committed to finding, sharing, and updating the best product deals for you to score the best savings. Our team of experts regularly checks in on the deals we share to ensure they are still live and obtainable. We’re sorry if you’ve missed out on this deal, but don’t fret — we’re constantly finding new chances to save and sharing them with you at ZDNET.com. 

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    We aim to deliver the most accurate advice to help you shop smarter. ZDNET offers 33 years of experience, 30 hands-on product reviewers, and 10,000 square feet of lab space to ensure we bring you the best of tech. 

    In 2025, we refined our approach to deals, developing a measurable system for sharing savings with readers like you. Our editor’s deal rating badges are affixed to most of our deal content, making it easy to interpret our expertise to help you make the best purchase decision.

    At the core of this approach is a percentage-off-based system to classify savings offered on top-tech products, combined with a sliding-scale system based on our team members’ expertise and several factors like frequency, brand or product recognition, and more. The result? Hand-crafted deals chosen specifically for ZDNET readers like you, fully backed by our experts. 

    Also: How we rate deals at ZDNET in 2025

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  • Sean ‘Diddy’ Combs guilty on two of five charges, banks ignoring interest calls, pear dinkum giant | Australia news

    Sean ‘Diddy’ Combs guilty on two of five charges, banks ignoring interest calls, pear dinkum giant | Australia news

    Morning everyone. Although he could still face years in prison for two charges of transportation to engage in prostitution, Sean “Diddy” Combs fell to his knees in relief and his supporters celebrated wildly outside after a jury in New York found the music mogul not guilty of the more serious charges of sex trafficking and racketeering. A Guardian Australia analysis shows the big four banks are not making it easy for customers to get bonus interest despite watchdog recommendations, auditors have condemned the navy’s handling of bribery allegations, and a Victorian city is bidding to be the “capital of big things”.

    Australia

    Water flowing out of Australia’s largest urban water supply will add to the risk of flooding after a damaging and complex low-pressure system. Photograph: Dean Lewins/EPA

    • Storm eases | The damaging weather system that has brought widespread havoc to much of coastal New South Wales is expected to ease today. But heavy conditions will continue along parts of the coast and thousands remain without power.

    • ‘Factional hacks’ | Newly elected Liberal senator Jess Collins has hit out at “factional hacks” in the party’s NSW branch, insisting a push for quotas to boost female representation is the wrong approach for trying to beat Labor at the next election.

    • All at sea | Defence officials failed to properly document and investigate bribery allegations made against navy contractor officials, a scathing audit report on the multibillion-dollar commissioning and maintenance of two military ships has found.

    • Bank blank | More than 18 months after regulatory advice that Australia’s major banks should help customers qualify for bonus interest rates on savings products, several of the recommendations have not been implemented by the big four, an analysis by Guardian Australia has found.

    • Pear share | The regional Victorian city of Shepparton is in the running to be the “capital of big things” with a $1.3m plan to build a giant pear to go alongside the world’s largest Murray cod.

    World

    Donald Trump, joined by House speaker Mike Johnson, speaks to the press in Washington in May. Republicans have grappled with the so-called ‘one big beautiful’ bill’s price tag – it is set to raise the deficit by US$5tn – and its impact on the US healthcare system. Photograph: Anadolu/Getty Images

    • Trump’s ‘big, beautiful bill’ | The House of Representatives is at a standstill as Republican leaders continue to try to rally holdouts against Donald Trump’s sweeping tax cut and spending legislation, after it cleared the Senate with the narrowest of margins. And after last-minute negotiations, the US and Vietnam struck a trade agreement that sets 20% tariffs on many of the south-east Asian country’s exports.

    • Exclusive | The Israeli military used a 230kg bomb – a powerful and indiscriminate weapon that generates a massive blast wave and scatters shrapnel over a wide area – when it attacked a target in a crowded beachfront cafe in Gaza on Monday, evidence seen by the Guardian has revealed.

    • Combs guilty | A New York Jury has found Sean “Diddy” Combs guilty of two counts of engaging women in prostitution but was cleared of the more serious offences of sex trafficking and racketeering, after a closely watched seven-week federal trial marked by emotional and graphic testimony. Outside the court, supporters danced and celebrated the verdict. Here are some key moments from the court drama.

    • Reeves’ tears | The UK chancellor, Rachel Reeves, appeared to be left in tears at prime minister’s questions as the Tory leader, Kemi Badenoch, attacked the government over its U-turn on welfare cuts. That climbdown leaves the government with its authority shredded and a £5bn hole to plug.

    • Drought threat | As Europe’s heatwave moved eastwards, a new report says that drought is pushing tens of millions of people around the world to the edge of starvation.

    Full Story

    In 2019, the people of Bougainville overwhelmingly voted in favour of independence. Composite: Mike Bowers/Guardian Australia

    Bougainville’s rocky path to independence

    Nour Haydar speaks to Ben Doherty about the road to independence for Australia’s Pacific neighbour and the risk of repeating mistakes from the past.

    Full Story

    Bougainville’s rocky path to independence

    In-depth

    After five consecutive seasons of finishing in the bottom two, the Kangaroos need to start performing on the biggest stages again. Photograph: James Wiltshire/AFL Photos/Getty Images

    It’s been miserable being a fan of North Melbourne in recent years. But the AFL club’s centenary celebrations are a chance for everyone involved to show that their investment in top-end picks and highly talented youth might just be about to pay off, writes Martin Pegan.

    Not the news

    ‘I truly feel like no one can hurt me as badly as my sister did.’ Photograph: Antonio Guillem Fernández/Alamy

    After years of fighting with her sister, Lucinda Price writes today about how it took their father’s cancer diagnosis for them “to form a truce after 26 years of full-pelt warfare … Our hatred just silently slipped away. I guess I felt as though my parents finally deserved to experience having children who didn’t hate each other”.

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    Sport

    Josh Flook, left, of the Reds celebrates scoring a try with Lachie Anderson. Photograph: Darren England/AAP

    • Rugby union | Queensland Reds put up a good fight but the British & Irish Lions had too much class as the second tour match ended in a 52-12 defeat for the local side in Brisbane last night.

    • Tennis | British No 1 Emma Raducanu set up a huge third-round match against Aryna Sabalenka after beating 2023 champion Marketa Vondrousova at Wimbledon, while defending men’s champion Carlos Alcaraz breezed through against plucky Ollie Tarvet. British tennis player Jodie Burrage has said she has had to stop herself looking at her phone due to online abuse – some from gamblers, some from about her appearance – after her first-round Wimbledon exit.

    • Cricket | India’s captain, Shubman Gill, made an unbeaten century as he dug in to steady his team and hold off England’s bowlers on the first day of the second test at Edgbaston.

    • Women’s football | Euro 2025 hosts Switzerland were defeated by Norway 2-1 this morning after Finland secured a narrow win against 10-player Iceland in the opening match. And Matildas star Ellie Carpenter has joined Sam Kerr at Chelsea with a big move from Lyon.

    The Australian claims the public service has grown to a record size under the Albanese government. The management of Victoria’s water would be reshaped to enshrine traditional owners as rights holders under a proposal from the truth-telling inquiry, the Age reports. The Courier Mail looks at how the Brisbane-based beauty product business Lucas Papaw went from near-bust to boom in five years. And residents on the south coast of NSW might not have seen many in the past couple of rain-drenched days but this season’s whale sightings are at a record high, the Mercury reports.

    What’s happening today

    • Economy | New vehicle sales figures for June released at 11am and international trade data from the ABS at 11.30am.

    • Brisbane | The Queensland deputy premier, Jarrod Bleijie, gives an Olympics update.

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    And follow the latest in US politics by signing up for This Week in Trumpland.

    Brain teaser

    And finally, here are the Guardian’s crosswords to keep you entertained throughout the day. Until tomorrow.

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  • Ozempic-style drugs treat type 1 diabetes, not only type 2, study finds

    Ozempic-style drugs treat type 1 diabetes, not only type 2, study finds

    Semaglutide, the active ingredient in Ozempic, and other drugs in the same class have revolutionized the treatment of obesity and type 2 diabetes. Now, a clinical trial suggests the medicines can treat type 1 diabetes, as well.

    The trial results, published June 23 in the journal NEJM Evidence, suggest semaglutide can improve blood sugar levels and induce weight loss in people with type 1, potentially introducing a new drug that could be used along with insulin to manage the disease.

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