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Immunogenicity and safety of the domestic and imported live-attenuated varicella vaccine in healthy Chinese populations: a systematic review and meta-analysis | BMC Infectious Diseases
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Three reasons why England can retain their title
Lauren James: England’s ‘cheat code’
Two years ago, Olympics.com asked the question: Is Lauren James England’s next breakout star?
The answer was, quite comfortably, yes.
Her inclusion in the 23-player roster for EURO 2025 was thrown into question at the back end of the domestic season when she picked up an injury. Much to the relief of fans, James was named in the squad.
Any doubts over her inclusion were soon dismissed when James made a 30-minute appearance, in which she bagged an assist, in the Lionesses’ 7-0 thumping of Jamaica before jetting off to Switzerland.
James’s availability is a game-changer for the England camp.
She is a supreme footballer with bags of ability despite being just 23. The ball seems to act as a companion as opposed to an object when she’s in possession, gliding across the pitch and brushing off competitors with ease.
The Chelsea forward is one of those players that can change the game in an instant, a moment of magic out of nowhere to turn it on its head. A difference maker.
It has been acknowledged by national team captain Leah Williamson previously, the defender telling BBC Sport: “I think she’s a cheat code.
“I enjoy being on the same team as her. The girl is incredible.”
Make no mistake, football is a team game, and no single player is responsible for winning trophies.
When you have one that possesses the ability of James, though, being successful in the pursuit of said trophies becomes a whole lot easier.
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Swiss stage, Swiss army knife: Dybantsa does it all for USA
LAUSANNE (Switzerland) – AJ Dybantsa came to Lausanne on a mission – winning the FIBA U19 Basketball World Cup 2025 to become a back-to-back FIBA youth world champion.
The projected number 1 pick in the 2026 NBA Draft has United States just two wins from that goal thanks to an amazing all-around game and great off-court personality.
Let us know what you think and vote:
Who will be named FIBA U19 Basketball World Cup 2025 TISSOT MVP?
USA thus far has been challenged only twice, and both times Dybantsa has been there to shine for the team.
In the opening game against Australia, the Americans were never really able to fully put them away and Dybantsa collected 18 points, 3 rebounds and 2 assists. But most importantly, he was a menace driving to the basket, converting 12 of 15 free throws.Dybantsa played his usual versatile game in the next three games with limited minutes on the floor, picking his spots and scoring 16 points against France and Cameroon and then totaling 7 points in 12 minutes in a blowout of Jordan in the Round of 16.
But USA were faced with a major challenge against Canada and Dybantsa was there for his best game of the tournament: 22 points on 5 of 8 shots and 12 of 13 free throws, 4 rebounds, 3 assists and 3 steals in a 108-102 win.
The 18-year-old himself is strictly business off the court with the media. He answers journalists’ questions but is short and to the point.
“
It’s a blessing to be here and represent my country
AJ Dybantsa “It’s a blessing to be here and represent my country,” he said about being back on the global stage after taking the title at the FIBA U17 World Cup 2024. “It’s not any different, it’s the same mission. Gold, I’m only here for gold.”
Instead of pressing for more information from Dybantsa, why not let the people around him in Lausanne speak about him?
“
A world class talent and teammate
Coach Tommy Lloyd “He’s a world class talent but he’s also a world class teammate. He does a really good job playing through the team concept. He’s really not trying to play for himself. So that’s been really refreshing,” USA head coach Tommy Lloyd said about Dybantsa.
And when asked about what impresses him most about the guard, Lloyd added: “Amazing physical ability, good IQ, willingness to play within the team concept. I dont know if he is necessarily trying to come here and trying to be the leading scorer. I just think he’s trying to make sure USA comes out on top in the end.”
Daniel Jacobsen is playing with Dybantsa for the first time as the big man is part of the 2006-born generation, which played the FIBA U18 AmeriCup 2024 last summer.
“I think he’s a great player. Obviously he can do it all on the court. But more importantly he’s a really good teammate. He’s able to share the ball, especially with a star-studded team. He can play more of a role. He’s been awesome so far.”
Let us know what you think and vote:
Who will be crowned U19 World Cup 2025 champions?
Morez Johnson also played with the U18 team last summer and is teaming up with him for the first time on a USA squad.
“I don’t think AJ is worried about any pressure. That is important. The game is still a game at the end of the day. You can’t worry about that. And he’s handling that very well,” Johnson said.
And what about Dybantsa off the court?
“He’s a very vocal guy. He’s a leader by example and he talks. That is very important that you talk to the guys. A lot of guys are shy when they are around other good players – not AJ,” Johnson added.
AJ is a walking highlight reel
Dybantsa is one of seven players in Lausanne who were on the USA team at last summer’s FIBA U17 World Cup.
“Obviously he’s gotten better. He’s shooting the ball better and he gets to his spots. People can’t guard him so you have to foul him. He’s getting to the free throw line at a higher rate,” said Caleb Holt about the difference between last summer and this one.
“AJ is great. Everybody knows he’s a team player and he can get a bucket. AJ’s the number one player in the country for a reason.”
Tyran Stokes got to know Dybantsa well after playing with him the entire 2023-24 season in high school and the AAU circuit and then last summer in Istanbul with USA Basketball. Dybantsa transferred high schools for this past season and Stokes sees a difference.
“I got to watch him day and night in the gym. I could see he has a great work ethic and great motor. Him being at Utah Prep and being out of the way really helped him a lot. He was able to lock in on what he was able to do, which is get better and stay in the gym. And I can really see that translate, especially from the high school level to the FIBA level,” Stokes said.
Another teammate from the U17 national team with Dybantsa against is JJ Mandaquit, who played with him this past season at Utah Prep.
“He’s grown a lot from a leadership standpoint, from his game. Obviously his shooting has gotten a lot better, but also the leadership part – making sure everybody stays together and plays the right way,” Mandaquit said.
And when asked how he shows that leadership, Mandaquit answered: “He jokes around a lot and dances. He’s always posting videos on TikTok. He gets our team going in the locker room with the music and dancing.”
Going back to Dybantsa himself, the dynamic guard said his experience in Türkiye helped him know what to expect in Lausanne.
The best AJ Dybantsa photos from the U17 World Cup 2024
The best AJ Dybantsa photos from the U17 World Cup 2024
The best AJ Dybantsa photos from the U17 World Cup 2024
The best AJ Dybantsa photos from the U17 World Cup 2024
The best AJ Dybantsa photos from the U17 World Cup 2024
The best AJ Dybantsa photos from the U17 World Cup 2024
The best AJ Dybantsa photos from the U17 World Cup 2024
The best AJ Dybantsa photos from the U17 World Cup 2024
The best AJ Dybantsa photos from the U17 World Cup 2024
The best AJ Dybantsa photos from the U17 World Cup 2024
The best AJ Dybantsa photos from the U17 World Cup 2024
The best AJ Dybantsa photos from the U17 World Cup 2024
The best AJ Dybantsa photos from the U17 World Cup 2024
The best AJ Dybantsa photos from the U17 World Cup 2024
“Just playing together. We’re kind of unbeatable with all the talent we have. So we just have to play together,” Dybantsa said.
And having that U17 core back is a benefit for the whole team, he says, adding: “It’s better for us because we have good chemistry.”
Mikel Brown also talked about Dybantsa and said he’s a big part of the team’s success.
“I am blessed to have the opportunity to play alongside him in this tournament. He does a little bit of everything. He’s kind of a Swiss army knife,” said Brown, who was a member of the U18 team last summer.
“AJ keeps it simple. He’s very unselfish and he wants the best for his teammates. That’s something that people don’t always see. He’s always being a good teammate.”
A good teammate who makes a great team even greater.
You should check these ones too:
FIBA U19WC MVP Ladder: Who will guide their country to the title?
FIBA U19WC MVP Ladder, volume 2: Unexpected guests
FIBA
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Warning: Thanks to AI you must use “phishing-resistant” passkeys to replace vulnerable passwords
Google and Microsoft have been warning users to stop using passwords to protect their accounts and use passkeys instead. What’s a passkey, you ask? It is a digital credential that allows you entry into an app or website without typing in a username and password. Instead, you use the same methods that you employ to unlock your device. For example, with a passkey you might use:- Biometrics: Fingerprint or facial recognition. Examples include Face ID, Touch ID, Android Fingerprint/Face Unlock, and Windows Hello.
- PIN/Pattern: This would use the same method you use to unlock your phone with a PIN code or a pattern.
Leading American identity and access management (IAM) company Okta says that it has seen threat actors use vO, an AI tool, to develop phishing sites that impersonate legitimate sign-in web pages. Okta says that threat actors are now able to use AI to create a “functional phishing site” from a simple text prompt. “Vercel’s v0.dev is an AI-powered tool that allows users to create web interfaces using natural language prompts. Okta has observed this technology being used to build replicas of the legitimate sign-in pages of multiple brands, including an Okta customer.”“The observed activity confirms that today’s threat actors are actively experimenting with and weaponizing leading GenAI tools to streamline and enhance their phishing capabilities. The use of a platform like Vercel’s v0.dev allows emerging threat actors to rapidly produce high-quality, deceptive phishing pages, increasing the speed and scale of their operations.”
-Okta
Okta Threat Intelligence watched in real time as threat actors used the Vercel platform to host multiple phishing sites that pretended to be legitimate websites for well-known brands such as Microsoft 365 and some cryptocurrency firms. Using AI to create these bogus websites means that the old red flags, such as spelling and grammatical mistakes, can no longer be used to warn you of a phishing attack.
Even two-factor authentication (2FA) can’t be counted on to protect you. The best defense is to add passkeys to any account where it is an option and, if possible, eliminate the use of passwords for those accounts that allow you to do so. If you must use a password on an account, make it unique, long, and back it up with non-SMS 2FA.Continue Reading
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12 die after Karachi building collapse, Commissioner blames residents for mishap – ANI News
- 12 die after Karachi building collapse, Commissioner blames residents for mishap ANI News
- Search continues as death toll from Lyari building collapse rises to 15 Dawn
- Death toll rises to 14 in Karachi building collapse Ptv.com.pk
- Govt to relocate residents of derelict buildings: Ghani The Express Tribune
- At least 8 dead after building collapses in Karachi’s Lyari area Business Recorder
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Why Is This Car Rolling Down the Street on Fire?
Content creator Wiktor Ivanovko stitches a shocking video of a burning car driving down the street. Ivanovko claims the flaming car overheated due to the Northstar V-8’s head gasket failing.
The Facebook post went viral, generating 370,200 views as of this writing.
What Cars Had the Northstar V-8 Engine?
In the post, Ivanovko speculates that the cause of the engine fire was due to the head gasket failure in a vehicle with a Northstar V-8 engine.
“This is what happens when a Northstar V-8 engine head gasket fails. It overheats slightly,” Ivanovko says. “Slightly” is a sarcastic understatement, as the car was blazing down the road on fire. The question is, are these engines still in production, and which cars had the Northstar V-8?
The Northstar V-8 engine’s production began in 1993. It remained in production until 2011, according to CarBuzz. The Northstar V-8 engine was considered General Motors’ most complex engine at the time, featuring double overhead camshafts, four valves per cylinder, an aluminum engine block, and aluminum cylinder heads. During production, this V-8 engine was used for Cadillac, Pontiac, and Buick models, but mostly for Cadillac.
The Cadillac models that featured the V-8 in the debut were the Seville, Eldorado, and Allante. The Northstar V-8 immediately exhibited world-class luxury car performance refinement that American automakers had lacked, Autoweb reports.
While the buzz was real and exciting during the 90s, there was a slight issue that turned into a major one involving the head bolts.
What Caused the Head Gasket Failures?
The Truth About Cars reports that the head gasket failures were primarily due to issues with the head bolts and their ability to maintain clamping force under heat. The head bolts were threaded too finely, leading to stretching and loss of tension over time under heat cycling and stress.
This so-called “stretching” of the head bolts would cause them to strip the metal off the block as the threads pulled away. This resulted in a loss of cylinder pressure. When this happened, the coolant entered the cylinders, exhaust, and eventually engine oil, which led to overheating and cooking the head gasket.
While issues within the cylinders or exhaust were not always visible, a ruined head gasket led to milkshake-like brownish oil under the engine’s oil filler cap.
The issues were then known generally as a head gasket failure, or the “Northstar Condition.”
So, when coolant is on the loose and ends up in the oil, it’s best to avoid driving entirely.
What Are Signs of the Northstar Head Gasket Failure?
Northstar Performance reports these are the most common signs of head gasket failure on a Northstar engine:
- Overheating.
- High pressure build-up in the coolant surge (fill) tank that remains when the engine cools off.
- White smoke from the exhaust.
- Coolant smell from the exhaust.
- Engine temperature spikes during acceleration or climbing steep grades.
- Coolant in the oil, which makes oil milky white or light brown.
- Sudden severe oil leak coming from rear main seal area.
A few tests can be done to determine how things are looking. First, a combustion leak test kit can be picked up from your local auto shop. This will check for exhaust gasses being present in the cooling system.
Another test that can be done is a quick acceleration run on the highway. Before doing this, be sure there is enough coolant. This test entails driving the car up to 70 miles per hour and dropping the speed to monitor coolant temperature. When doing this, the coolant should never go past the ⅝ mark or go over 240 degrees Fahrenheit. If the temperature keeps climbing up, pull over immediately to let the car cool down.
The last thing you want to do is let the engine overheat and catch fire like the Ghost Rider in the viral post.
Many commenters couldn’t believe their eyes and chimed in with some humor.
“He’s on his way to O’reilly’s Auto,” one Facebook commenter wrote.
“There’s a few things that would make a man keep driving in that condition. I’ll leave the list to your imagination,” another said.
“I thought it was Ghost Rider,” a third joked.
Motor1 has contacted Wiktor Ivanovko via Facebook direct message. This story will be updated should he respond.
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🧬 DeepMind’s new AI identifies the gene variants most likely to cause disease
- AlphaGenome can predict how individual DNA changes affect gene expression and protein production across the entire human genome.
- The tool outperformed 22 of 24 other computer models in identifying specific features in DNA sequences.
- Academic researchers can use AlphaGenome free of charge while DeepMind works on commercial availability.
AI model analyzes entire genome
DeepMind has developed AlphaGenome, an AI tool that can explain how genetic changes affect gene function. The model builds on the company’s previous success with AlphaFold, which predicts how proteins fold into their three-dimensional shapes.
AlphaGenome can analyze DNA sequences up to one million base pairs long. The tool predicts where genes start and end, which can vary between different cell types. It also captures how RNA is processed and how much RNA is produced from the genes.
Outperforms other models
In tests, AlphaGenome performed better than 22 of 24 other computer models in identifying specific features in individual DNA sequences. This included coding and non-coding regions as well as transcription factor binding sites. The model also outperformed 24 of 26 models in predicting the effect of genetic variants on gene regulation.
AlphaGenome is the first AI tool that can handle the entire genome, not just the estimated 2 percent that codes for proteins. As Hani Goodarzi from the University of California San Francisco explains, the model can for the first time predict exactly where and how an RNA variant is expressed directly from a DNA sequence.
Helps cancer research
Marc Mansour, cancer molecular biologist at University College London, describes how his laboratory compares genomes from patients’ cancer cells with healthy cells. Thousands of individual letter changes emerge, but it’s difficult to determine which ones have functional consequences. AlphaGenome ranks the variants most likely to be significant, allowing researchers to focus their follow-up studies.
Caleb Lareau from Memorial Sloan Kettering Cancer Center, who received early access to the AI, calls it the most comprehensive attempt to explain every possible change in the 3-billion-letter sequence of the human genome. Instead of testing hundreds of things, he can focus on a few after being guided to the right spot.
Trained on decades of data
The model builds on massive molecular biology databases produced over decades by publicly funded consortia. These include results from experiments tracking how certain mutations in human and mouse cells affect properties such as RNA production and levels of transcription factors.
By training on these datasets, AlphaGenome has learned to decipher DNA and identify both genes and non-gene sequences that orchestrate gene activity. The model can also identify genetic variants most likely to produce significant changes.
Useful for synthetic biology
The ability to predict how genetic changes affect gene expression becomes equally valuable for synthetic biologists. The AI can suggest whether newly developed genetic sequences would have beneficial effects before testing them in laboratory experiments.
DeepMind plans to release the source code and model weights when a peer-reviewed version of the paper is published. This will enable researchers to customize the tool for their own projects. Pushmeet Kohli, DeepMind’s vice president of research, says the company shared the model with external biosecurity experts who assessed that the benefits far outweigh the risks.
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5 Health Benefits of Drinking Tea Every Day
Far beyond a comforting ritual, your daily cup of tea might be doing more than keeping you hydrated. Enjoyed around the world for centuries, tea is packed with nutrient compounds that may support everything from heart health to brain function. Here’s what nutrition experts say about the health benefits of drinking tea every day.
- Avery Zenker, RD, MAN, registered dietitian at MyHealthTeam
- Meghan Laszlo, MS, RD, CSO, clinical nutrition coordinator at Cedars-Sinai Hospital in Los Angeles
Supports Heart Health
“Regular tea consumption has been associated with possible reductions in blood pressure, LDL (‘lousy’) cholesterol, and triglycerides, which are all biomarkers linked to cardiovascular disease,” says Avery Zenker, RD, MAN, registered dietitian at MyHealthTeam. Much of this benefit comes from polyphenols, particularly EGCG, which is found in the highest amounts in green tea and, to a lesser extent, in black tea, and has shown promising protective effects for heart health.
“Green tea has been associated with decreased risk of death from cardiovascular disease of all kinds, where three cups per day was linked to a 26% lower risk of death,” says Zenker. “It’s also associated with reduced risks of cardiovascular complications, including coronary artery disease, heart attack, and stroke.”
Black tea also delivers a dose of flavonoids. “Flavonoids may help support vasodilation, the relaxing of blood vessels, which may help reduce blood pressure,” Zenker explains. There’s also some evidence that hibiscus tea may help reduce blood pressure and cholesterol, possibly due to its anthocyanin content, which are antioxidants with anti-inflammatory properties.
Boosts Cognitive Function
When it comes to cognitive function, one of the most studied compounds in tea is caffeine, found in green, black, and oolong varieties, which has been shown to enhance performance during long, demanding cognitive tasks and improve alertness, arousal, and vigor.
“L-theanine, another compound in tea, promotes relaxation, reduces tension, and increases calmness,” says Zenker. “When combined, caffeine and L-theanine have been found to improve attention-switching and alertness, though less than caffeine alone.” This duo may also support better focus, memory, and distraction control. Found in both green and black tea, L-theanine can help take the edge off caffeine, reducing overstimulation and helping you stay calm but alert.
Green tea’s anti-inflammatory and antioxidant properties may also play a role in supporting brain health. “The antioxidant properties of tea compounds, particularly L-theanine, may help protect brain cells from oxidative stress, potentially slowing cognitive decline,” says Zenker.
Helps Your Gut Microbiome
The polyphenols in tea also feed the good bacteria in your gut, helping support the growth of beneficial microbes like Firmicutes and Bacteroidetes, Zenker points out. An optimal ratio of these is linked to a lower risk of obesity and metabolic disorders.
“Tea has been found to decrease the amount of inflammatory compounds produced by gut bacteria, like lipopolysaccharides,” says Zenker. Tea also helps fuel the production of short-chain fatty acids, beneficial compounds that gut microbes make during digestion, supporting a more balanced gut microbiome overall. “Green tea in particular has been found to support the growth of helpful bacteria and decrease the growth of harmful bacteria,” says Zenker. “This finding was associated with intake of four to five cups of green tea per day.”
Regulates Your Metabolism
Green tea, especially, contains bioactive compounds that can help regulate metabolism. While the size of the effect can vary, Zenker says EGCG has been found to boost fat burning and improve insulin sensitivity.
Drinking tea in general has been linked to a lower risk of type 2 diabetes, with about two cups per day showing benefits, and a 15% reduced risk observed at four cups per day, Zenker points out.
“Many chronic diseases, such as type 2 diabetes, are closely related to metabolic dysfunction, inflammation, and insulin resistance. By influencing inflammatory processes, tea consumption may indirectly support metabolic health and insulin sensitivity,” Zenker says.
Supports Blood Sugar Control
Black tea, which contains about 269 milligrams of flavan-3-ols per 8-ounce cup, is linked to better blood sugar control. The American Academy of Nutrition and Dietetics recommends a daily intake of 400 to 600 milligrams of flavan-3-ols from food sources to help reduce risks associated with cardiovascular disease and diabetes. “Flavan-3-ols have been found to reduce blood pressure, improve cholesterol and blood sugar control. The higher the intake, the lower the risk of CVD,” says Meghan Laszlo, MS, RD, CSO, clinical nutrition coordinator at Cedars-Sinai Hospital in Los Angeles. “Flavan-3-ols lower LDL cholesterol, triglycerides, A1C, and raise HDL cholesterol.”
Regular tea drinking is also associated with a reduced risk of cardiovascular disease mortality, coronary heart disease, stroke, and type 2 diabetes.
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