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  • Avbelj upsets the ERC formbook to lead in Rome

    Avbelj upsets the ERC formbook to lead in Rome

    Roared on by thousands of fans, Avbelj took 56.2sec to complete the 1.30-kilometre Colosseo ACI Roma test in his Pirelli-equipped Škoda Fabia RS Rally2.

    Andrea Mabellini was second fastest, 0.4sec behind surprise early pacesetter Avbelj with MRF-shod Simone Tempestini third. Andrea Crugnola, who is chasing a hat-trick of wins on his home round of the FIA European Rally Championship, shared the fourth quickest time with Simone Campedelli.

    “I was pushing very hard but it is the Power Stage for the Italian championship so it was important,” the Italian-domiciled Slovenian said. “I’m happy with the result.”

    Mabellini, who earlier won the Qualifying Stage with his commemorative roof livery, said: “Tomorrow we start first on the rand so we can sleep a little bit less than the others tonight and that is the most important thing. For the rest it will be nice. How beautiful is my roof with the Colosseum on it. I think we will have great pictures tonight.”

    Tempestini said: “Half a second is let’s say some time when the stage is less than one minute. We had a clean run. I did a little mistake, I tried to do a perfect stage but it was not like that. It is a pleasure to be here and race so close to the Colosseum. I think this is something that helps our sport, so big congrats to the people organising this rally.”

    Behind sixth-placed Roberto Daprà, Michelin’s ERC points leader Miko Marczyk was seventh, Mads Østberg eighth followed by Dominik Stříteský with Norbert Herczig and Giandomenico Basso equal 10th best.

    Jon Armstrong, Simon Wagner, Fabio Andolfi and Marco Signor round out the top 15.

    Pirelli-equipped Ford Fiesta Rally3 driver Adrian Rzeźnik beat Hubert Kowalczyk to the fastest time in the FIA ERC3 category, while Tuukka Kauppinen set the FIA Junior ERC pace in his Hankook-equipped Lancia Ypsilon Rally4 HF.

    Rally di Roma Capitale resumes tomorrow (Saturday) with the 6.47-kilometre Collepardo Pozzo d’Antullo stage from 08:30 local time.

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  • Q2 2025 Recap: Cardiology News and Updates

    Q2 2025 Recap: Cardiology News and Updates

    HCPLive Cardiology
    Q2 2025 Recap

    The second quarter of 2025 brought a steady stream of momentum in cardiology, with developments spanning early-stage innovation, late-phase trial results, and new FDA approvals. This quarter’s recap includes 3 key regulatory milestones—including a major hypertension approval and a fast-tracked gene editing therapy—as well as 3 headline-making trial readouts that challenged, confirmed, or extended the evidence base in high-risk populations.

    Rounding it out, Don’t Miss a Beat delivered 3 episodes from the frontlines of ACC, Heart in Diabetes, and beyond—offering expert commentary on treatment sequencing, cardiorenal strategies, and emerging approaches in ATTR-CM. Here’s a look at what mattered most this past quarter in cardiovascular care.

    FDA News in Cardiology

    FDA Grants Fast Track Designation to VERVE-102 Gene Therapy

    On April 11, 2025, the FDA awarded Fast Track designation to Verve Therapeutics’ VERVE-102 gene editing medicine to lower low-density lipoprotein cholesterol (LDL-C) levels in individuals with hyperlipidemia and high cardiovascular risk. The regulatory agency cleared the Investigational New Drug (IND) application for VERVE-102 in March 2025, when the company provided interim data from the dose–escalation part of the Phase 1b Heart-2 trial.

    FDA Accepts NDA Submission for Oral Semaglutide 25 mg

    On May 2, 2025, Novo Nordisk announced the FDA accepted its NDA for a once-daily 25 mg oral formulation of semaglutide (Wegovy) for chronic weight management in adults with obesity or overweight. Based on Phase 3 OASIS 4 trial results, the pill showed significant efficacy in reducing weight in patients with at least one comorbidity. According to Novo Nordisk, this could become the first oral GLP-1 therapy approved for obesity treatment. The drug also aims to reduce cardiovascular risk in patients with established heart disease. The FDA decision is expected in Q4 2025.

    FDA Approves Triple Combination Drug GMRx2 (Widaplik) for Hypertension Treatment

    On June 9, 2025, the FDA approved GMRx2 (Widaplik), the first single-pill triple combination therapy—telmisartan, amlodipine, and indapamide—approved for initial treatment of hypertension in adults likely needing multiple drugs. Based on positive results from 2 phase 3 trials and the VERONICA study, Widaplik demonstrated superior blood pressure control and good tolerability. According to George Medicines, the pill’s design aligns with global guidelines recommending early use of combination therapy. A US launch is expected in Q4 2025.

    Trial Updates

    VERVE-102 Safely Cuts LDL-C Levels in Early Phase 1b Results

    On April 14, 2025, Verve Therapeutics announced data from their phase 1b Heart-2 trial of VERVE-102 for the treatment of patients with heterozygous familial hypercholesterolemia (HeFH) and/or premature coronary artery disease (CAD). A single infusion of the in vivo gene editing medicine achieved dose-dependent reductions in blood PCSK9 and LDL-C, with a mean LDL-C reduction of ≥50% and a maximum decrease of nearly 70% at the highest dose.

    Phase 3 Trial Results Announced for Sotatercept-csrk in Pulmonary Arterial Hypertension

    On June 23, 2025, Merck announced positive topline results from the Phase 3 HYPERION trial, showing sotatercept-csrk (WINREVAIR) significantly reduced time to clinical worsening in newly diagnosed PAH patients at intermediate or high risk. Based on a composite primary endpoint, the trial met its goal, with additional benefits seen in walking distance, NT-proBNP levels, and functional class. According to Merck, these findings extend sotatercept’s evidence base to earlier-stage patients, building on prior success in advanced PAH. On July 02, 2025, Merck announced the FDA’s acceptance of their BLA for a label expansion, which was granted Priority Review.

    ACHIEVE: Spironolactone Fails to Reduce Cardiovascular Risk in Dialysis Patients

    On June 6, 2025, results from the ACHIEVE trial presented at ERA 2025 showed that spironolactone did not significantly reduce cardiovascular death or heart failure hospitalization in dialysis patients. Based on data from over 2,500 participants, the primary outcome occurred in 20.5% of the spironolactone group vs. 21.6% in the placebo group (HR 0.92; P = .35). According to investigators, the findings challenge earlier studies suggesting large cardioprotective benefits. Additionally, spironolactone was associated with a higher rate of severe hyperkalemia, occurring in 6.6% of patients.

    Don’t Miss a Beat

    During the second quarter of 2025, Don’t Miss a Beat released a trio of episodes, including a pair of in-person episodes from the floor at the American College of Cardiology and the Heart in Diabetes meeting. Check out our episode summaries below!

    Treatment Sequencing in New Era of Heart Failure Management

    In this episode recorded at ACC 2025, the hosts examine the expanding treatment landscape for HFpEF, advocating for early combination therapy using SGLT2 inhibitors, MRAs, and incretin-based drugs to improve outcomes. They debate rapid versus risk-based implementation, highlight phenotyping for tailored care, and discuss upcoming trials and the promise of fixed-dose combinations to enhance adherence.

    CONFIDENCE Trial and Combination T2D, CKD Therapy at Heart in Diabetes 2025

    In this episode, the hosts review findings from the CONFIDENCE trial showing that combination therapy with finerenone and empagliflozin significantly outperformed either drug alone in reducing albuminuria in patients with CKD and type 2 diabetes. They discuss the trial’s design, safety profile, and implications for rapid implementation strategies and future fixed-dose combination treatments in cardiorenal care.

    Don’t Miss a Beat: Navigating the ATTR-CM Care Landscape, With Ahmad Masri, MD

    In this episode, the hosts and their guest discuss major advances in treating transthyretin amyloid cardiomyopathy, highlighting FDA-approved agents like tafamidis, acoramidis, and vutrisiran, while examining challenges such as residual risk, late-stage symptom limitations, and lack of head-to-head data. They also explore future strategies including amyloid-clearing therapies and early intervention trials like ACT-EARLY, which could shift the focus toward prevention in high-risk patients.

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  • U.S. researchers develop AI model improving sudden cardiac death prediction

    LOS ANGELES, July 4 (Xinhua) — Researchers at Johns Hopkins University have developed a new artificial intelligence (AI) model that significantly outperforms current clinical guidelines in identifying patients at high risk of sudden cardiac death, according to a newly published study.

    The AI system, known as Multimodal AI for ventricular Arrhythmia Risk Stratification (MAARS), integrates cardiac MRI images with a wide range of patient health records to detect hidden warning signs, offering a new level of precision in cardiovascular risk prediction.

    The study, published this week in Nature Cardiovascular Research, focused on hypertrophic cardiomyopathy, one of the most common inherited heart conditions and a leading cause of sudden cardiac death in young people.

    “Currently we have patients dying in the prime of their life because they aren’t protected and others who are putting up with defibrillators for the rest of their lives with no benefit,” said senior author Natalia Trayanova, a researcher focused on using AI in cardiology. “We have the ability to predict with very high accuracy whether a patient is at very high risk for sudden cardiac death or not.”

    Clinical guidelines used in the United States and Europe currently have an estimated accuracy of only 50 percent in identifying at-risk patients. In contrast, the MAARS model demonstrated an overall accuracy of 89 percent, and 93 percent for patients aged 40 to 60 — the group at the greatest risk.

    The AI model analyzes contrast-enhanced MRI scans for patterns of heart scarring — something that physicians have traditionally found difficult to interpret. By applying deep learning to this previously underused data, the model identifies key predictors of sudden cardiac death.

    “Our study demonstrates that the AI model significantly enhances our ability to predict those at highest risk compared to our current algorithms and thus has the power to transform clinical care,” said co-author Jonathan Chrispin, a Johns Hopkins cardiologist.

    The team plans to further test the new model on more patients and expand the new algorithm to use with other types of heart diseases, including cardiac sarcoidosis and arrhythmogenic right ventricular cardiomyopathy. Enditem

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  • What the teams said – Friday in Great Britain

    What the teams said – Friday in Great Britain

    Mercedes

    Russell sounded concerned about tyre wear in FP1, especially compared to the Ferraris – he was running behind Hamilton, and had a sneaky look at his former team mate’s rubber in the opening session. The better news is the car is in the mix in the hands of Russell, while Antonelli took a little longer to get going as he struggled to adjust to the soft compound tyre. The team mates reversed that trend in FP2 – Antonelli looking both quicker, and more comfortable on the softs than his team mate. As for their form, Mercedes will be hoping the forecast drop in temperatures for tomorrow help them as they look a shade off the pace as it stands.

    George Russell – FP1: 1:27.163, P5; FP2: 1:26.523, P8

    “It’s been a warm day here at Silverstone, with track temperatures upwards of 40°C. That made it a challenge to look after the tyres; it is frustrating that we are affected by the weather as much as we are, but we’re all focused on improving that, particularly as we head into summer months where this will be the norm.

    “If the forecast cooler conditions do appear over the rest of the weekend, that will likely help us.We won’t just sit here hoping that is the case though. We will work hard overnight to make improvements and give ourselves the best race car for Saturday and Sunday. I love being here at Silverstone, I love seeing all the fans, and I am hopeful that we can still get ourselves into the fight at the front, put on a good show for them, and give them something to cheer about.”

    Kimi Antonelli – FP1: 1:27.367, P9; FP2: 1:26.383, P6

    “Today was not the easiest Friday of the year we’ve had so far. The temperature was quite a bit higher than expected and that made looking after the tyres slightly more challenging. That said, the car felt decent, and I was happy with the overall balance. Silverstone is a great track, and I enjoyed being out there, exploring the limits, and pushing the car. There are clear areas for us to work on this evening, and for me to improve in my driving, so I’m excited to see what improvements we can make overnight.

    “Tomorrow is forecast to be slightly cooler which should help us. We should have some cloud cover too which may help keep the track temperature lower. If we can make gains this evening, then our goal is still to get ourselves into the fight with those who looked strong today, such as McLaren and Ferrari. Let’s see what we can do.”

    Andrew Shovlin, Trackside Engineering Director

    “It is always good to get on track at Silverstone, the closest race to our two factories at Brackley and Brixworth. Knowing many of our colleagues will be in the grandstands this week cheering us on at the circuit is always a boost. That will provide added motivation for our work overnight as we aim to find more pace in the car after a tricky Friday.

    “We opted to only run the Medium and Soft compounds today, like most other teams. We were able to complete plenty of single lap and long run work but were limited by rear tyre overheating. Silverstone puts a lot of energy into the tyre, and we saw track temperatures around 40°C, so the phenomenon was not completely unexpected, but it proved to be our main constraint on the long runs, alongside a tricky car balance in the gusty conditions.

    “We will need to make a step overnight to be able to challenge at the front this weekend, and we have several areas we are already targeting to do that. We will work diligently trackside and in the simulator at Brackley this evening to find gains ahead of FP3 and Qualifying tomorrow.”

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  • Azerbaijan signs $2 billion investment agreements with Pakistan on sidelines of ECO summit

    Azerbaijan signs $2 billion investment agreements with Pakistan on sidelines of ECO summit

    Eight killed in Karachi building collapse, exposing city’s crisis of unsafe housing


    KARACHI: A five-story residential building collapsed in Karachi’s densely populated Lyari neighborhood on Friday, killing at least eight people and trapping many others, in yet another tragedy underscoring the city’s crisis of unsafe, aging structures.


    Rescue workers, aided by local residents, scrambled to pull people from the debris of the Fotan Mansion building, recovering both bodies and injured survivors. The collapse took place around 10:30 a.m., jolting the community.


    “I suddenly woke up … it felt like there were tremors, like an earthquake,” said Salman Ahmed, who was sleeping in a nearby building at the time of the incident and later rescued two children.


    “At the moment the building collapsed, nothing was visible,” he recalled. “There was so much dust and smoke that no one could understand what had happened. “We could hear voices coming from underneath [the rubble].”


    It was not immediately clear how many families lived in the building, but residents estimated that around 40 people were inside when it collapsed. Many of the occupants were members of the low-income Hindu minority community.


    As of Friday evening, a large rescue operation was still underway, with cranes clearing debris and rescuers working against time to reach those still trapped beneath the rubble.


    “They handed me a three-month-old baby girl, she was alive,” said Maya Sham, a relative of a family living in the building. “Right now, two of their sons and three daughters-in-law are still trapped. But we can still hear voices from inside.”


    The collapse devastated families like that of Megbhai, a member of the Hindu community, which largely resided in the building.


    Karachi Mayor Murtaza Wahab confirmed that six people had died and eight were rescued alive. He said the building had long been on the city’s “danger list.”


    “This building was declared dangerous, and a couple of notices were issued to the occupants to vacate because of its structure,” Wahab told Arab News at the site. “But unfortunately, people chose to risk their lives, and they did not vacate.”


    Pakistan’s largest city — home to over 20 million people — faces a chronic housing shortage. Many low-income residents live in dilapidated buildings that have escaped regular maintenance. Authorities have declared nearly 588 buildings dangerous in Karachi, most in the congested Old City area.


    According to the Sindh Building Control Authority (SBCA), Fotan Mansion had been declared unsafe as far back as 2012.


    “This building was declared dangerous by the SBCA in 2012 and had been served multiple notices over the years,” SBCA spokesperson Shakeel Dogar told Arab News. “Before the recent rains, public announcements were also made in the area, but unfortunately, no one was willing to vacate,” he said, adding that it was the responsibility of the district administration to enforce the SBCA’s evacuation directives.


    Mayor Wahab said rescue efforts remained the top priority, with accountability and investigation to follow.


    “Our administration, our machinery is here on the ground,” he said. “Once we’re done with the rescue aspect, we will focus on who was responsible for this negligence or omission.”


    RECURRING TRAGEDY


    Friday’s incident is the latest in a string of deadly building collapses in Karachi.


    In February 2020, a five-story building collapsed in Rizvia Society, killing at least 27 people. The following month, another residential structure came down in Gulbahar, claiming 16 lives.


    In June 2021, a three-story building in Malir collapsed, killing four. And just last year, in August, a building collapse in Qur’angi led to at least three deaths.


    Most of these structures had either been declared unsafe or were built without proper approval.


    Experts say that despite repeated disasters, there has been little progress in enforcing building codes or relocating residents from hazardous structures.


    “The incident of the building collapse in Lyari is deeply tragic,” said Muhammad Hassan Bakhshi, chairman of the Association of Builders and Developers of Pakistan (ABAD). “It is alarming that despite having a list of dangerous buildings, the SBCA did not take action to get them evacuated.”


    He urged the Sindh government to reassess buildings citywide and equip rescue teams with modern tools and technology.


    With hundreds of buildings still listed as unsafe, authorities now face mounting pressure to prevent future disasters.


    “The way out is that we must follow what the law says,” said Mayor Wahab when asked if anyone would be held accountable. “If citizens don’t listen to us, the political leadership and the administration have to play their part to convince those people.”


    “Nobody wants to leave their house… but we must learn from our mistakes and ensure no such untoward incident takes place in the future,” he said.

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  • FO calls out India for ‘patronising terrorism’ from Afghan soil

    FO calls out India for ‘patronising terrorism’ from Afghan soil

    Listen to article

    Foreign Office Spokesperson Shafqat Ali Khan stated that cross-border terrorism remains the central challenge in its ties with Afghanistan, asserting that India is actively ‘patronising terrorism ‘ in Afghan territory.

    In a weekly briefing on Friday, he said Pakistan has repeatedly raised concerns over terrorist sanctuaries in Afghanistan posing grave threats to regional stability. “Counter‑terrorism remains a sticking point,” he noted, accusing India of “patronising terrorism against Pakistan.”

    Khan also condemned the BJP government’s demolition of over 500 shrines in Uttarakhand as evidence of rising Islamophobia. He described the act as “another demonstration of the virulence with which the current dispensation in India is pursuing its anti‑Muslim agenda.”

    Responding to Indian aggression in the aftermath of the Pahalgam incident, Khan warned against unilateral militaristic aggression. “No state can allow another to violate its sovereignty and territorial integrity at will,” he said, affirming Pakistan’s preparedness to defend its sovereignty “with full vigour.”

    Referring to remarks made by India’s External Affairs Minister S Jaishankar on alleged nuclear blackmail, Khan asserted that such talk exposes India’s insecurity about Pakistan’s defence capability.

    He stated that Pakistan’s conventional forces are “adequate to deter India without the self‑imposed nuclear blackmail that New Delhi suffers from.”

    On the Indus Waters Treaty, he welcomed an interim ruling by the Permanent Court of Arbitration that rebuked India’s unilateral suspension of the treaty. Describing India’s action as “totally illegal,” he said the award “vindicates Pakistan’s position in a very clear fashion.”

    Moreover, Khan confirmed Pakistan and India exchanged prisoner lists on July 1 under the 2008 Consular Access Agreement — Pakistan shared 246 names of Indian or Indian-origin detainees, while India handed over a list of 463 Pakistani prisoners. He urged both nations to ensure the welfare of detainees.

    He also highlighted Pakistan’s participation in regional diplomacy, saying Prime Minister Shehbaz Sharif led the delegation at the 17th ECO Summit in Azerbaijan, where he held bilateral meetings and advanced Pakistan’s policy agenda. Deputy PM Ishaq Dar also reached out to Turkey’s leadership ahead of Turkish Foreign Minister Hakan Fidan’s imminent visit.

    Responding to whether Pakistan would seek US mediation in its dialogue with India, the spokesperson said Islamabad prefers diplomacy over conflict. “It is India’s choice whether it treads the path of belligerence or takes steps for dialogue and reconciliation.”

    Meanwhile, he firmly reiterated Pakistan’s unwavering support for Palestine. He called for a sovereign Palestinian state along pre-1967 borders with Al Quds Al Sharif as its capital, emphasising that any ceasefire in Gaza must end occupation and respect Palestinian rights.

    “The road to peace lies not through normalisation under duress, but through justice, freedom and dignity for the Palestinian people,” he added.

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  • Buemi promoted to third in Jakarta after FIA hearing

    Buemi promoted to third in Jakarta after FIA hearing

    Additional footage from the Envision Racing’s rool hoop camera not available in the immediate aftermath of the race when the penalty was applied, for an incident between Buemi and Mahindra Racing’s Edo Mortara, showed that Buemi’s move was within the rules.

    “The driver of Car 16 argued that the New Element shows that his overtaking manoeuvre was legit, that he was always in control of his car and that when the slight contact between the two cars occurred, he was fully alongside Car 48.” said an FIA statement explaining the amended decision.

    “The driver of Car 48 agreed with what the driver of Car 16 said and added that he barely felt the contact. Upon careful consideration of the circumstances, the Stewards find that no single party bears whole or predominant responsibility for the collision.

    “Therefore, the Stewards decide to reverse the Decision 12. As a result the penalty (i.e. five second time penalty and one penalty point) on Car 16 is removed and the Stewards determine that no further action will be taken in relation to this collision.”

    Find out more

    CALENDAR: Sync the dates and don’t miss a lap of Season 11

    WATCH: Find out where to watch every Formula E race via stream or on TV in your country

    TICKETS: Secure your grandstand seats and buy Formula E race tickets

    SCHEDULE: Here’s every race of the 2024/25 Formula E season

    HIGHLIGHTS: Catch up with every race from all 10 seasons of Formula E IN FULL

    PREDICTOR: Get involved, predict race results and win exclusive prizes

    HOSPITALITY: Experience Formula E and world class motorsport as a VIP

    FOLLOW: Download the Formula E App on iOS or Android

     

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  • Save 33% Off the New Travel-Friendly Baseus Enercore Wall Charger With Built-in USB Cable

    Save 33% Off the New Travel-Friendly Baseus Enercore Wall Charger With Built-in USB Cable

    Baseus recently released a new line of Enercore wall chargers that is designed to be the ultimate travel friendly accessory while delivering enough power output to quickly charge your portable electronics. Even better, you can take advantage of some early Amazon Prime Day discounts. Currently the 67W model is on sale for Amazon Prime members for just $36.99 after you apply an additional 5% off coupon code “GOHTHZJQ“. The most unique feature of this charger is the built-in retractable USB-C cable, which saves you from bringing along yet another travel accessory.

    Baseus Enercore Wall Chargers with Built-In Cable

    Amazon Prime Member Exclusive

    Baseus 67W USB C Charger with Retractable Cable

    The Baseus Enercore wall charger features a handy 32-inch USB Type-C cable that retracts neatly inside the unit when it isn’t being used. The plug sits in a recessed nook so that it won’t get snagged. The prong is also foldable to prevent premature breakage. There are two additional USB Type-C ports for charging multiple devices simultaneously.

    The 65W output model is more than enough to fast charge a Nintendo Switch (or Switch 2), Steam Deck, Asus ROG Ally, and Apple iPhone 16 at their maximum rate. Although the Legion Go and Rog Ally X can support up to 100W of charging, the wall adapter that comes with these gaming handhelds has a 65W max output, so this charger is just as competent.

    Looking for a power bank for extended battery life? Check out our favorite portable power banks.

    Should You Shop Now or Wait for Prime Day?

    It’s a more complicated question then you might think. For now, I’d say this power bank deal is a good deal and similar to what we’ll see for 2025 Prime Day sales at Amazon, and worth snapping up while it’s still on sale.

    Eric Song is the IGN commerce manager in charge of finding the best gaming and tech deals every day. When Eric isn’t hunting for deals for other people at work, he’s hunting for deals for himself during his free time.

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  • Toyota Yaris 1.3 and 1.5 Expected Prices in Pakistan after New Taxes; Full List here

    Toyota Yaris 1.3 and 1.5 Expected Prices in Pakistan after New Taxes; Full List here

    Pakistan’s auto industry is seeing yet another round of price hikes as top automakers continue to revise rates upward. As Suzuki and KIA recently jacked up prices across their vehicle lineups, Toyota is now expected to follow suit, signaling no immediate relief for car buyers.

    Toyota Yaris, one of the company’s most popular sedans, is likely to see a 2% price increase across all variants. The expected new prices reflect the growing burden on consumers amid ongoing economic pressures.

    Toyota Yaris Price Update

    Models New Expected Price
    Yaris Sedan GLI MT 1.3 4,568,000
    Yaris Sedan ATIV MT 1.3 4,825,000
    Yaris Sedan GLI CVT 1.3 4,850,000
    Yaris Sedan ATIV CVT 1.3 5,700,000
    Yaris Sedan ATIV X CVT 1.5 (Beige) 6,380,000
    Yaris Sedan ATIV X CVT 1.5 (Black) 6,445,000

    Toyota Yaris GLI MT 1.3, which currently cost around 4,479,000, is expected to rise to 4,568,580. MT 1.3 variant will likely cost 4,824,600, while GLI CVT 1.3 is said to climb to 4,855,200.

    Yaris ATIV X CVT 1.5 expected price is likely to be from 6,380,000 to 6,445,000.

    Pakistani government started new one-time tax called Climate Levy with tax to be added to price of cars that run on petrol or diesel, including hybrid cars. The amount of tax depends on the engine size.

    Toyota Yaris 1 3 And 1 5 Expected Prices In Pakistan After New Taxes Full List Here

    Petrol cars like the Toyota Corolla Cross, Kia Sportage Hybrid, and others are not exempt because they still use fuel and can’t run far on battery only. So, they will be taxed just like regular fuel cars. A full list has been made to show the new prices of all locally made cars after this tax is added.

    Toyota Yaris is one of top selling subcompact cars known for decent fuel efficiency, smooth transmission, and some safety features, making it considerable for daily driving. It offers mileage between 11–15 km/l, low maintenance costs, and wide availability of spare parts, it falls short in performance and handling.

     

    KIA Sportage, Picanto prices increase from July 2025 [New Complete Rate List]

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  • U.S. researchers develop AI model improving sudden cardiac death prediction-Xinhua

    LOS ANGELES, July 4 (Xinhua) — Researchers at Johns Hopkins University have developed a new artificial intelligence (AI) model that significantly outperforms current clinical guidelines in identifying patients at high risk of sudden cardiac death, according to a newly published study.

    The AI system, known as Multimodal AI for ventricular Arrhythmia Risk Stratification (MAARS), integrates cardiac MRI images with a wide range of patient health records to detect hidden warning signs, offering a new level of precision in cardiovascular risk prediction.

    The study, published this week in Nature Cardiovascular Research, focused on hypertrophic cardiomyopathy, one of the most common inherited heart conditions and a leading cause of sudden cardiac death in young people.

    “Currently we have patients dying in the prime of their life because they aren’t protected and others who are putting up with defibrillators for the rest of their lives with no benefit,” said senior author Natalia Trayanova, a researcher focused on using AI in cardiology. “We have the ability to predict with very high accuracy whether a patient is at very high risk for sudden cardiac death or not.”

    Clinical guidelines used in the United States and Europe currently have an estimated accuracy of only 50 percent in identifying at-risk patients. In contrast, the MAARS model demonstrated an overall accuracy of 89 percent, and 93 percent for patients aged 40 to 60 — the group at the greatest risk.

    The AI model analyzes contrast-enhanced MRI scans for patterns of heart scarring — something that physicians have traditionally found difficult to interpret. By applying deep learning to this previously underused data, the model identifies key predictors of sudden cardiac death.

    “Our study demonstrates that the AI model significantly enhances our ability to predict those at highest risk compared to our current algorithms and thus has the power to transform clinical care,” said co-author Jonathan Chrispin, a Johns Hopkins cardiologist.

    The team plans to further test the new model on more patients and expand the new algorithm to use with other types of heart diseases, including cardiac sarcoidosis and arrhythmogenic right ventricular cardiomyopathy.

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