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  • Scientists Turns Cockroaches into Cyborg Saviors for Disaster Rescue

    Scientists Turns Cockroaches into Cyborg Saviors for Disaster Rescue

    Singapore’s Nanyang Technological University (NTU) has just taken one of our planet’s most abhorred insects — the Madagascar hissing cockroach — and turned it into a cyborg savior.

    The breakthrough led by Professor Hirotaka Sato features the world’s first automated robotic system for assembling cyborg insects, where miniature electronic backpacks are attached to the cockroaches, turning them into biohybrid robots.

    NTU’s Cyborg Insect Factory Line

    Outfitting cockroaches with electronics for remote control isn’t new; it has been done before, but the process is excruciatingly slow; it takes an hour to assemble the electronics on an insect manually.

    NTU’s automated system, on the other hand, uses AI and computer vision to identify the best spot for placing the lightweight backpack composed of sensors, a battery, and control circuitry. In tests, the automated system completed such assemblies on four insects in under 8 minutes — 30 times faster than manual assembly!

    Aiding Time-Sensitive Operations

    More impressive was the mass-produced backpacks’ ability to stimulate the insects’ movement using 25% less voltage, thereby decreasing overstimulation and increasing energy efficiency. These factors are critical for meeting the crucial 72-hour, life-and-death window after a disaster.

    In recent tests, ten such cyborg cockroaches were sent to Myanmar as part of a humanitarian mission following a 7.7-magnitude earthquake. They proved adept at navigating rubble and tight crevices, as well as detecting human presence, something conventional robots would have failed at due to size or battery limitations.

    Reliable Cyborg Applications

    NTU has also created a swarm navigation algorithm allowing cockroaches to work in groups. These groups are led by a leader insect whose movements coordinate with the others, reminding one of robot swarms sans energy-intensive motors or high computational power.

    In real-life scenarios, this could make NTU’s cyborgs an optimal choice for inspecting critical infrastructure, military reconnaissance, and swarm-based object transport.

    Image credit: ArtMediaFactory/Shutterstock

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  • Speech by H.E. Adylbek Kasymaliev, Chairman of the Cabinet of Ministers of the Kyrgyz Republic at the Aga Khan Award for Architecture prize-giving ceremony

    Speech by H.E. Adylbek Kasymaliev, Chairman of the Cabinet of Ministers of the Kyrgyz Republic at the Aga Khan Award for Architecture prize-giving ceremony

    His Highness Prince Rahim Aga Khan,
    Distinguished guests,
    Esteemed representatives of the global architectural community,
    Laureates of the Award,

    For the Kyrgyz Republic, hosting the Aga Khan Award for Architecture ceremony is a great honour and a profound responsibility.

    We regard the participation of more than 200 prominent architects, scholars and high-ranking guests from various countries of the world in this grand event as a sign of respect and appreciation for our nation. We are delighted to welcome you to the Ala-Too mountains, in the warm and hospitable land of Kyrgyzstan.

    Through this grand ceremony, we find ourselves at the centre of the world community’s attention. Such events are rare. Global sports Olympiads, world competitions in culture and the arts, and international exhibitions of science and technology belong to this same category of historic events. Therefore, we believe that this day will hold great significance in our history.

    Organising the World Nomad Games was already a major event that captured global attention. Today, we are witnessing the grand ceremony of a worldwide architectural competition.

    This Award, which holds special significance for the global community, has for nearly half a century been not only a recognition of outstanding architectural projects but also a symbol of humanism, cultural diversity and the pursuit of harmony between people and nature.

    Unlike many other awards, the Aga Khan Award celebrates buildings not only for their beauty or form; it also considers their impact on society, their role in preserving cultural heritage and their significance in community development. This Award clearly demonstrates that architecture is not a display of wealth, but a necessity and a responsibility to future generations.

    In a time challenged by climate change, urbanisation and social trials, it is precisely such projects that give us hope and show the way toward building a sustainable and just future.

    Kyrgyzstan has long been distinguished by its rich history, deep culture and unique architecture. The lifestyle and cultural values of our people have been reflected for centuries in architectural monuments. The ancient cities of Balasagyn and Uzgen, the historic Burana Tower, the architectural complex and mausoleums in Uzgen, and the caravanserais in Tash-Rabatall of these testify to the creativity of our ancestors and their contribution to world civilisation.

    Today, building on this heritage, we strive not only to carefully preserve it and pass it on to future generations but also to develop contemporary architecture. New constructions grounded in national characteristics and historical traditions define the identity of our country and become another remarkable symbol introducing Kyrgyzstan to the world.

    In recent years, Kyrgyzstan’s construction sector has been developing particularly dynamically. Millions of square metres of housing have been put into use, and modern schools, kindergartens, hospitals, sports complexes and cultural centres are being built.

    As of now, a new chapter in large-scale construction and architectural development is unfolding. Among these projects are:

    • The construction of Kemin-City, a new environmentally friendly city that will become a modern centre for living and business;
    • The new Jalal-Abad Airport, designed not only to enhance transit capabilities but also to incorporate energy-efficient and modern engineering solutions;
    • The Ala-Too Resort mountain-ski cluster, globally competitive yet environmentally responsible, protecting and supporting nature rather than harming it;
    • The China-Kyrgyzstan-Uzbekistan railway corridor, which will significantly strengthen the region’s transport and economic connectivity.

    These are projects that ensure not only infrastructural development but also ecological balance.

    In addition, modern schools and medical complexes being built in the regions will adhere to green standards. Furthermore, environmentally friendly technologies will be applied in the reconstruction of international highways, as well as in the construction of bridges and engineering structures, minimising their impact on the environment.

    All these initiatives not only transform the architectural appearance of our cities and villages but also create green urban environments and establish infrastructure in harmony with nature. Along with creating new jobs and strengthening social and cultural spaces, they ensure architectural development.

    Today, we stand to congratulate and honour the winners and participants of the 16th cycle of the Aga Khan Award for Architecture. It is especially symbolic that this ceremony takes place during the 25-year period of cooperation between the Kyrgyz Republic and the Aga Khan Development Network.

    The partnership between the Kyrgyz Republic and the Aga Khan Development Network over the past quarter-century has been built on trust, mutual support and creativity. Within the framework of this cooperation, joint projects in education, health care and culture have been implemented, making a significant contribution to improving the quality of life for citizens. We are ready to continue strengthening this trusted relationship and to implement new initiatives together.

    Dear laureates,

    Each of your projects inspires millions of people around the world. You have demonstrated that architecture is not merely a collection of walls and roofs, but a commitment to caring for people, protecting their dignity and safeguarding their future.

    As seen in the video above, the Khudi Bari project by Marina Tabassum Architects in Bangladesh offers a replicable solution made of bamboo and steel for communities forced to relocate due to climatic and geographical changes. The community centre in West Wusutu Village, China, was restored using brick and has become a new space for culture and dialogue, taking into account the traditions and needs of the local Hui Muslim community.

    The Revitalisation of Historic Esna project in Egypt transformed a neglected area into a thriving centre of culture and tourism, while in Iran, the Majara complex on Hormuz Island and the renovated Jahad metro station in Tehran demonstrated how traditional materials combined with innovation can breathe new life into public spaces. In Pakistan, the Vision Pakistan Center in Islamabad has become a source of education and hope for youth, and in Palestine, the Wonder Cabinet in Bethlehem united craftsmanship, innovation and culture in a unique model of connected architecture.

    Each of these projects is unique in its own way. Yet, they all share a common goal – to make architecture a tool for transformation and innovation. They serve as a factor that strengthens society and fosters unity among citizens, becoming symbols that connect generations and values. Moreover, these projects act as a bridge between traditional architecture and contemporary trends, preserving national identity while creating new spaces that meet global standards.

    On behalf of the people of Kyrgyzstan, allow me to express our deep gratitude to His Highness Prince Rahim Aga Khan. Thanks to your leadership, the Award is serving as a unique platform that brings together architects, engineers, scholars, artisans and local communities. Your contribution to the development of culture, education and architecture is invaluable.

    The Aga Khan Award for Architecture is a great initiative that reminds us that buildings are a mirror of society. The cities and structures we create today will shape the face of tomorrow. It also reflects the values we will pass on to future generations.

    Kyrgyzstan will continue to develop its construction sector, taking confident steps toward creating modern cities and villages where every individual feels part of a harmonious space, where nature and culture are preserved, and where they become the foundation of progress.

    I wholeheartedly congratulate all the winners of the 16th cycle of the Award! I express my deep gratitude to the organisers and wish you renewed inspiration, bold ideas and a firm belief that your work will make the world a better place.

    May the Aga Khan Award for Architecture continue to serve as a symbol of hope, creativity and mutual understanding for all humanity!

    Thank you for your attention.

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  • Netanyahu admits Israel economically isolated, says will need to become ‘super-Sparta’

    Netanyahu admits Israel economically isolated, says will need to become ‘super-Sparta’

    Prime Minister Benjamin Netanyahu admitted on Monday that Israel is facing increasing isolation on the world stage, and will have to become a more self-reliant “super-Sparta” in the years to come.

    His comments, delivered as European countries have called for arms embargoes and sanctions against Israel during the ongoing war in Gaza, were seized on by political opponents and high-tech industry groups who blamed the premier for Israel’s troubled status on the world stage.

    “Israel is in a sort of isolation,” Netanyahu acknowledged, at a conference of the Finance Ministry’s accountant general in Jerusalem.

    “We will increasingly need to adapt to an economy with autarkic characteristics,” he continued, calling the term for economic self-sufficiency, closed off from global trade, “the word I most hate.”

    “I am a believer in the free market, but we may find ourselves in a situation where our arms industries are blocked. We will need to develop arms industries here — not only research and development, but also the ability to produce what we need,” he said.

    Faced with a scenario of “Athens and Sparta,” Israel would be “Athens and super-Sparta,” Netanyahu said. “There’s no choice; in the coming years, at least, we will have to deal with these attempts to isolate us.”

    Israel is facing two new threats since the start of the war, Netanyahu explained: demographic changes in Europe as a result of immigration from Muslim-majority countries and the influence of anti-Israel actors on digital platforms, aided by new technologies.

    The premier said these challenges had long been in the works, but came to the fore during the ongoing war sparked by the Hamas terror group’s October 7, 2023, attack in southern Israel.

    The prime minister began his speech by praising Jerusalem’s success in its military campaigns against Iran and its terror proxies throughout the region.

    According to Netanyahu, these campaigns “eliminated an existential threat that was hanging over our heads, and all of the [other] problems — economic, social, internal — would be irrelevant if we were destroyed.”

    Pedestrians walk past a mural at Palestine Square in central Tehran on July 8, 2025, as an anti-Israeli billboard is displayed on the facade of a building depicting the Prime Minister Benjamin Netanyahu with text in Persian and Hebrew reading, ‘Netanyahu lost another war; you fell victim to Bibi’s political games. Where will the next failure to stay in power occur?’ (AFP)

    He stressed, in particular, the damage done to Iran’s nuclear and ballistic missile programs, asserting that Tehran would have built a nuclear bomb or two, as well as the equivalent destructive power in ballistic missiles, within a year, had Israel not intervened.

    However, he said, Israel’s longstanding security challenges have been replaced by new diplomatic issues, which, he said, were long-maturing, but have come to the surface since the war’s start.

    PM says isolation result of EU migration, online propaganda

    Netanyahu first addressed demographic changes in Europe, where “limitless migration” has resulted in Muslims becoming a “significant minority — very vocal, very, very belligerent.” These countries’ Muslim citizens are pressuring European governments to adopt anti-Israel policies, he claimed.

    “Their focus isn’t Gaza, it’s opposing Zionism in general, and sometimes an Islamist agenda that challenges those states,” the premier added.

    “This is creating limitations, and all sorts of sanctions, on Israel — it’s happening. It’s a process that’s been at work for the last 30 years, and especially in the last decade, and that changes Israel’s international situation. Clear as day,” he said.

    The situation could bring arms embargoes and — though these are only threats for now — “the beginnings of economic sanctions,” the prime minister warned.

    Pro-Palestinian, anti-Israel protesters hold a ‘Wanted’ poster depicting Prime Minister Benjamin Netanyahu, during the 21st and last stage of the Vuelta a Espana 2025, in Madrid on September 14, 2025. (Oscar DEL POZO / AFP)

    The second challenge, according to Netanyahu, is the investment of Israel’s “rivals — both NGOs and states, like Qatar and China” — to “influence Western media with an anti-Israel agenda, using bots, artificial intelligence, and advertisements.” He cited TikTok as an immediate example.

    “This puts us in a sort of isolation,” he said, adding that Israel can fight demonization and incitement if it invests “very large sums” into efforts to counter those narratives.

    But for now, he said, Israel must quickly establish the capacity to produce everything it needs militarily without depending on foreign trade.

    Opposition fumes: PM ‘turned Israel into third-world country’

    Netanyahu’s comments drew immediate backlash from his domestic political opposition and from industry groups, as the Tel Aviv stock exchange dipped following the premier’s speech.

    Opposition Leader Yair Lapid said in a statement: “Isolation is not fate. It’s a product of a wrongheaded and failed policy by Netanyahu and his government, who have turned Israel into a third-world country, and aren’t even trying to change the situation.”

    Opposition Leader and Yesh Atid chairman MK Yair Lapid attends a Yesh Atid party conference in Tel Aviv, September 1, 2025. (Avshalom Sassoni/Flash90)

    The Democrats chair Yair Golan fumed that, “Netanyahu ‘blesses’ the citizens of Israel for the Rosh Hashanah holiday: To protect my seat, I need a forever war and isolation. And you all will sacrifice the state, the economy, and your children’s future, and their connection to the world. Our answer to this vile man: This year, we will replace you and save Israel.”

    Gadi Eisenkot, the former member of Netanyahu’s war government who recently left the National Unity party, blasted “the paralysis that has gripped Netanyahu and the ‘October 7 Cabinet’ in its management of the war in Gaza for more than a year,” adding: “If the prime minister doesn’t know how to fix the situation, then he should turn over the keys and return his mandate to the people, immediately.”

    Industry groups blast PM, as markets dip after speech

    Manufacturers’ Association of Israel President Ron Tomer said that Netanyahu “said publicly what we’ve been feeling and warning against: The Israeli brand, of creativity, demand, and success, has been seriously harmed in the world.”

    “Israeli industry will ensure that we are never lacking — not in security, not in food, and not in anything vital to the Israeli economy. That being said, an autarkic market will be a disaster for Israel’s economy and will influence every citizen’s quality of life,” he said.

    Ron Tomer, president of the Manufacturers Association of Israel attends an Economic Committee meeting at the Knesset, in Jerusalem, on January 16, 2023. (Yonatan Sindel/Flash90/File)

    The High-Tech for Israel Forum said in a statement: “Is this the prime minister’s vision — that we go back to being an orange seller?”

    And just minutes after the prime minister’s speech, leading indexes on the Tel Aviv stock exchange went down by as much as two percent, though it recovered by about half, later in the day.

    PM: China and Qatar trying to ‘besiege’ Israel

    Later on Monday, Netanyahu returned to the same themes, speaking to a delegation of 250 US state legislators at the Foreign Ministry in Jerusalem.

    “We value and cherish your support,” the premier told the delegation — the largest group of legislators from a single country ever to visit Israel — adding that “there is an effort to erode [that support].”

    “An effort to besiege — not isolate as much as besiege Israel — that is orchestrated by the same forces that supported Iran,” he continued.

    While Iran attempted “a military siege” on Israel through its network of terror proxies, and Israel was “able to break loose from that siege,” the premier said, “we will have to do several things to break loose from this siege that is organized by a few states.”

    Prime Minister Benjamin Netanyahu speaks during a ceremony at the Foreign Ministry in Jerusalem, September 15, 2025. (Olivier Fitoussi/ POOL)

    He named those states: “One is China. And the other is Qatar. They are organizing an attack on Israel… [through] the social media of the Western world and the United States. We will have to counter it, and we will counter it with our own methods,” he said.

    Later, speaking to i24 News, Netanyahu said: “Have [China and Qatar] achieved global isolation [of Israel]? No. The US is with us, as are many other countries. But we do currently have a problem centered in Western Europe, and we are working and will continue to work to remove this blockade.”

    PM dismisses ‘doom-and-gloom forecasters’

    In a second stab at damage control following the stock market dip, the prime minister said in a statement Monday evening: “To all the doom-and-gloom forecasters in economics, in the end the Israeli stock market is the strongest in the world.”

    “The shekel has strengthened, the deficit has shrunk despite the war, and foreign investment in R&D is the highest in the world after the United States. Investing in Israel is the smart thing to do,” he said.

    Netanyahu added that his government will continue to “increase investments in weapons production so as not to be dependent on weak Western European leaders who give in to the extreme Muslim minorities in their countries — and that is exactly what we are doing.”

    His office also shared a graph showing that Israel ranks second in the world in R&D investment.


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  • Sri Lanka survive Hong Kong scare in Dubai

    Sri Lanka survive Hong Kong scare in Dubai

    Sri Lanka managed a four-wicket win in Dubai

    What’s the story

    Despite tumbling, Sri Lanka beat Hong Kong in Match 8 of the 2025 T20 Asia Cup at Dubai International Cricket Stadium.
    The Lankans successfully chased down what appeared to be a challenging 150, with Pathum Nissanka anchoring the chase.
    Nissanka hammered a formidable 78* after losing his opening partner, Kusal Mendis, early.
    Earlier, Anshuman Rath and Nizakat Khan played fine knocks for Hong Kong.

    Hong Kong off to fine start

    Hong Kong were off to a terrific start, with openers Zeeshan Ali and Anshuman Rath adding 41 runs.
    However, Zeeshan and Babar Hayat departed before 10 overs, leaving HK at 57/2. Dushmantha Chameera and Wanindu Hasaranga did the damage.
    However, Nizakat and Rath joined forces thereafter, taking the side past 110. The latter finally fell to Chameera, scoring 48 off 46 balls.

    Nizakat gets HK to challenging total

    While Rath departed, Nizakat remained unfazed.
    Despite seeing the departure of skipper Yasim Murtaza, he finished unbeaten on 52 off 38 balls. His knock was laced with 4 fours and 2 sixes.
    While Nizakat’s knock propelled Hong Kong to 149/4 in 20 overs, Chameera bagged figures of 4-0-29-2.
    Notably, Dasun Shanaka dismissed Murtaza in his only over.

    Special feat for Nizakat

    As per Cricbuzz, Nizakat became the second Hong Kong batter to have recorded a 50-plus score in the T20 Asia Cup.
    He joined Babar Hayat, who hammered an incredible 122 against Oman and 54 against UAE, both in 2016.
    In 118 T20Is, he raced to 2,376 runs at 22.41. His tally includes a strike rate of 121.22. This was his 12th half-century in T20Is.

    Kusal Mendis equals Kumar Sangakkara

    Kusal Mendis now has the joint-most wicket-keeping dismissals for Sri Lanka in T20Is, equaling the great Kumar Sangakkara.
    Both Mendis and Sanga now have 45 wicket-keeping dismissals across 56 innings.
    Mendis first took the catch of Zeeshan Ali in the fifth over. In the ninth over, Mendis stumped Babar Hayat to reach the landmark. Hayat came down the track against Hasaranga.

    Nissanka powers SL home

    Nissanka single-handedly powered Sri Lanka to victory in Abu Dhabi.
    He lost Kusal Mendis in the fourth over, while Kamil Mishara departed after scoring a run-a-ball 19.
    With Sri Lanka behind the required run-rate, Nissanka upped the ante and scored successive boundaries in the 13th over.
    Getting the chase under control, Nissanka was run out for a 44-ball 68 (6 fours and 2 sixes).

    SL tumble before winning

    With 32 required off 30 balls, SL were expected to win easily despite Nissanka’s runout.
    However, Murtaza dismissed Kusal Perera on the very next ball, reducing SL to 119/4.
    Charith Asalanka and Kamindu Mendis fell in the next seven balls, and suddenly, SL slumped to 127/6.
    However, Hasaranga released the pressure with a six off Murtaza. The former, along with Shanaka, sealed SL’s win.

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  • Maurice Bellan Named a Finalist in the 2025 National Law Journal Awards | Newsroom

    Maurice Bellan Named a Finalist in the 2025 National Law Journal Awards | Newsroom

    Global law firm Baker McKenzie is pleased to announce that Maurice Bellan, Managing Partner of the Washington, DC, office, has been named a finalist for DC Managing Partner of the Year in the 2025 National Law Journal Awards. This recognition honors law firm leaders whose achievements and influence have made a meaningful impact on their firms, their people and clients, and society at large.

    Maurice’s selection underscores his outstanding contributions to Baker McKenzie’s DC office and the broader firm community. As a member of the Dispute Resolution Practice and a former trial attorney at the US Department of Justice, Maurice is a highly respected practitioner known for exceptional commitment to client service. As Managing Partner of the Firm’s DC office, Maurice’s impact goes beyond legal work as he actively supports junior lawyers through a strong commitment to mentorship and talent development. His dedication to mentorship was recently recognized with the Best Mentor Award in the 2024 American Lawyer Industry Awards. Maurice was also named a 2025 BTI Client Service All-Star, a select group of attorneys identified by clients for delivering truly superior client service.

    The National Law Journal Awards celebrate individuals and organizations that have made a significant impact on the legal industry and the DC area. Winners will be announced at a ceremony in November. Learn more here.

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  • What CoreWeave’s new $6.3 billion contract with Nvidia says about the AI trade

    What CoreWeave’s new $6.3 billion contract with Nvidia says about the AI trade

    By Britney Nguyen

    The deal offers some reassurance to CoreWeave investors in light of the company’s heavy customer concentration and rampant competition for cloud offerings

    CoreWeave’s stock was up more than 6% during midday trading on Monday.

    CoreWeave Inc. and Nvidia Corp. are deepening their ties with a new cloud-services agreement valued at $6.3 billion – and the deal is giving CoreWeave investors some reassurance.

    The cloud-infrastructure provider (CRWV) said it entered a new order form with the artificial-intelligence chip maker earlier this month that will give Nvidia (NVDA) access to computing capacity that it can’t sell. Under the existing agreement, which was made in April 2023, when CoreWeave’s data-center capacity “is not fully utilized by its own customers, Nvidia is obligated to purchase the residual unsold capacity” until April 2032, CoreWeave said in a Securities and Exchange Commission report on Monday.

    The guarantee from Nvidia could help alleviate some investors’ concerns over the viability of CoreWeave’s business, which so far depends mainly on two customers and is subject to fierce competition, even with the insatiable appetite for AI compute.

    CoreWeave shares were up more than 6% during midday trading on Monday.

    The company serves developers and major tech companies, including Microsoft Corp. (MSFT) and OpenAI, by providing large-scale access to AI hardware like Nvidia’s graphics processing units (or GPUs) for intensive AI workloads such as training and inferencing. CoreWeave is one of a few emerging neoclouds, or AI hardware and service providers, that serve as an alternative to hyperscalers such as Amazon.com Inc.’s (AMZN) Amazon Web Services and Alphabet Inc.’s (GOOG) (GOOGL) Google Cloud. Microsoft’s Azure is also considered a hyperscaler rival.

    In a statement shared with MarketWatch, CoreWeave said the expanded contract with Nvidia “reflects the scale, trust and pivotal role CoreWeave plays in accelerating AI innovation worldwide.”

    An Nvidia spokesperson noted the “long lead times and 4-6 year customer commitments” that come with building the necessary data center capacity to meet ongoing industrywide demand.

    “To support startups and small to mid-sized companies, Nvidia and CoreWeave are proactively building data center infrastructure and provisioning data center capacity to meet evolving capital needs,” the spokesperson said.

    Before its initial public offering in March, CoreWeave announced that it would be delivering AI infrastructure to OpenAI through a contract worth up to $11.9 billion. It followed up with another deal in May with the ChatGPT maker that is worth up to $4 billion and will run through April 2029. In a Form-10Q for the period ended in June, CoreWeave disclosed that Microsoft, which is a top-backer for OpenAI, is one of its two largest customers. It also said that it expects “OpenAI to be a significant customer in future periods.”

    “Ultimately, CoreWeave’s focus on large customers is its greatest risk,” Seaport Research analyst Jay Goldberg wrote as he initiated coverage of CoreWeave’s stock with a neutral rating on Monday.

    CoreWeave’s stock has nearly tripled since its IPO in March.

    See more: CoreWeave’s stock has surged 38% in 4 days. Why investors might be getting ahead of themselves.

    However, MoffettNathanson analyst Nick Del Deo said last week that investors should be cautious about CoreWeave’s AI opportunity despite signals that AI demand still remains strong. While that provides for a “favorable” view for the company, “it’s inappropriate to think of CoreWeave’s infrastructure capabilities as singularly unique,” Del Deo said, adding that “they can be matched.”

    For example, Netherlands-based Nebius Group N.V., which is also considered an up-and-coming neocloud, announced last week that it had made a multiyear deal worth $17.4 billion with Microsoft to provide it with AI infrastructure capacity for a new data center in New Jersey.

    Although the move points to increasing AI demand driving major tech companies to look elsewhere from hyperscalers for compute capacity, in Del Deo’s view, it suggests “that the returns on delivering AI infrastructure to large customers are likely to compress due to competitive forces.”

    -Britney Nguyen

    This content was created by MarketWatch, which is operated by Dow Jones & Co. MarketWatch is published independently from Dow Jones Newswires and The Wall Street Journal.

    (END) Dow Jones Newswires

    09-15-25 1405ET

    Copyright (c) 2025 Dow Jones & Company, Inc.

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  • Nadofaragene Firadenovec NDA Accepted for Review in Japan for BCG-Unresponsive NMIBC

    Nadofaragene Firadenovec NDA Accepted for Review in Japan for BCG-Unresponsive NMIBC

    The Pharmaceuticals and Medical Devices Agency of Japan accepted for review the new drug application (NDA) seeking the approval of nadofaragene firadenovec in patients with Bacillus Calmette–Guérin (BCG)–unresponsive non–muscle-invasive bladder cancer (NMIBC).1

    The NDA is supported by data from a phase 3 trial conducted in Japan, which were shared during the 2025 Japanese Urological Association Annual Meeting. A single quarterly administration of nadofaragene firadenovec led to a complete response (CR) rate of 75% at 3 months in Japanese patients with high-risk, BCG-unresponsive NMIBC with carcinoma in situ (CIS) with or without concomitant high-grade Ta or T1 papillary lesions (n = 20).2

    Moreover, treatment-related adverse effects (AEs; n = 76) were observed in 80% of safety evaluable patients (n = 16); 64 of these AEs were grade 1 and occurred in 84.2% of patients and 12 of these AEs were grade 2 and occurred in 15.8% of patients. The toxicity profile was determined to be tolerable, with no grade 3 to 5 AEs reported.

    “Nadofaragene firadenovec represents an option for those who failed NMIBC treatment,” Professor Keiji Inoue, MD, PhD, of the Department of Urology at Kochi Medical School, stated in a news release.1 “As the first choice after BCG failure, this bladder-sparing gene therapy offers patients a non-chemotherapy option that transforms their own bladder cells into interferon-producing factories. The 75% CR rate achieved with convenient quarterly dosing provides hope for patients who previously faced limited treatment options.”

    What Was the Design of the Japanese Study?

    The open-label, phase 3 study plans to enroll a total of 25 patients with high-risk BCG-unresponsive NMIBC with CIS only, Ta/T1 high-grade disease with concomitant CIS, or Ta/T1 high-grade disease without concomitant CIS.3 This included patients who

    • Did not respond to BCG treatment and experienced persistent high-grade recurrence within 1 year after initiation of BCG
    • Those with CIS who relapsed within 12 months of their last intravesical treatment despite achieving an initial CR, and
    • Those with high-grade Ta/T1 NMIBC who relapsed within 6 months of their last intravesical treatment

    Additional eligibility criteria include life expectancy longer than 2 years, an ECOG performance status of 0 to 2. Upon enrollment, patients receive 75 mL of intravesical nadofaragene firadenovec once every 3 months via a urinary catheter without reinduction. Those who responded at the 3-month assessment will continue this dosing schedule until disease recurrence.2 The primary end point is CR rate at any time following the first dose.3 Secondary end points include duration of response (DOR), duration of event-free survival, time to cystectomy, overall survival (OS), and safety.

    What Is Nadofaragene Firadenovec, and What Data Have Previously Been Reported?

    The intravesical non-replicating gene therapy leverages a non-replicating adenovirus vector–based therapy containing the interferon alfa-2b gene. The product is administered via catheter directly into the bladder once every 3 months only. The approach leads to high and transient local expression of interferon alfa-2b protein, which strengthens the body’s natural capabilities to fight cancer.

    Previously, data from the single-arm phase 3 Study CS-003 (NCT02773849) showed that the therapy elicited a 51% CR rate at 3 months in evaluable patients with high-risk BCG-unresponsive NMIBC with CIS with or without concomitant high-grade Ta or T1 disease (n = 98).4,5 The median DOR was 9.7 months (range, 3-52+). Notably, 46% of those who experienced an initial CR (n = 23) continued to be free of high-grade recurrence at 1 year. These data led to the December 2022 FDA approval of nadofaragene firadenovec-vncg (Adstiladrin) in adult patients with high-risk BCG-unresponsive NMIBC with CIS with or without papillary tumors.

    At a median follow-up of 50.8 months (interquartile range, 39.1-60.0), 5.8% (95% CI, 2.2%-12.2%) of patients with CIS ± Ta/T1 (CIS; n = 106) were high grade recurrence free (HGRF) at 57 months; this was true for 15% (95% CI, 6.1%-27.8%) of those with Ta/T1 without CIS (Ta/T1; n = 50) at that time point.6 In the respective cohorts, the 57-month Kaplan-Meier–estimated HGRF survival rates were 13% (95% CI, 6.9%-12.5%) and 33% (95% CI, 19.5%-46.6%), respectively. Additionally, the 60-month cystectomy-free survival rate in the CIS cohort was 49% (95% CI, 40.0%-57.1%); in the Ta/T1 cohort, this was 59% (95% CI, 43.1%-71.4%). The 60-month OS rate was 80% (95% CI, 71.0%-86.0%) overall; in the CIS and Ta/T1 cohorts, the respective rates were 76% (95% CI, 64.6%-84.5%) and 86% (95% CI, 70.9%-93.5%).

    The data from the Japanese trial were consistent with US real-world data shared by the Mayo Clinic, which showed that nadofaragene firadenovec elicited a CR rate of 79% in patients with BCG-unresponsive NMIBC (n = 29).1,7 At a median follow-up of 8.2 months, 72% of patients had a CR or were free from high-grade recurrence at 3 months and more than half (62%) maintained response at 6 months. Moreover, 94% of patients avoided cystectomy and all were alive at 6 months.

    References

    1. Ferring Japan announces PMDA acceptance of NDA filing for nadofaragene firadenovec. News release. Ferring Pharmaceuticals Co., Ltd. September 11, 2025. Accessed September 11, 2025. https://www.businesswire.com/news/home/20250911332715/en/Ferring-Japan-announces-PMDA-Acceptance-of-NDA-Filing-for-nadofaragene-firadenovec
    2. Ferring announces initial data from phase 3 trial in Japanese patients demonstrating 75% complete response rate at 3 months with (nadofaragene firadenovec) in BCG-unresponsive NMIBC patients. News release. Ferring Pharmaceuticals. April 21, 2025. Accessed September 11, 2025. https://www.businesswire.com/news/home/20250421675994/en/Ferring-Announces-Initial-Data-from-Phase-3-Trial-in-Japanese-Patients-Demonstrating-75-Complete-Response-Rate-at-3-Months-with-nadofaragene-firadenovec-in-BCG-unresponsive-NMIBC-Patients1
    3. Safety and efficacy of FE 999326 administered intravesically to Japanese subjects with high-grade, BCG unresponsive, non-muscle invasive bladder cancer (NMIBC). ClinicalTrials.gov. Last updated February 13, 2025. Accessed September 11 ,2025. https://clinicaltrials.gov/study/NCT05704244
    4. FDA approves first gene therapy for the treatment of high-risk, non-muscle-invasive bladder cancer. News release. FDA. December 16, 2022. Accessed September 11, 2025. https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-first-adenoviral-vector-based-gene-therapy-high-risk-bacillus-calmette-guerin
    5. Nadofaragene firadenovec-vncg (Adstiladrin). Prescribing information; Ferring Pharmaceuticals; 2022. Accessed September 11, 2025. https://www.ferringusa.com/wp-content/uploads/sites/12/2022/12/ADSTILADRIN_pi.pdf
    6. Narayan VM, Boorjian SA, Alemozaffar M, et al. Efficacy of intravesical nadofaragene firadenovec for patients with BCG-unresponsive non-muscle invasive bladder cancer: 5-year follow-up from a phase 3 trial. J Urol. 2024;212(1):74-86. doi:10.1097/JU.0000000000004020
    7. Moyer J, Durant A, Nguyen M, et al. Real-world outcomes of nadofaragene firadenovec in BCG-unresponsive non-muscle invasive bladder cancer. J Clin Oncol. 2025;43(suppl 5):716. doi:10.1200/JCO.2025.43.5_suppl.716

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  • Architecture Award spotlights creative solutions

    Architecture Award spotlights creative solutions

    His Highness the Aga Khan elaborated on the importance of this pursuit: “Today, with the climate more volatile than ever, architects have a great responsibility, and an opportunity, to use their creativity to design the buildings that will buffer that volatility and protect us all – and especially the most vulnerable – from climatic risk,” he said.

    “This quality – flexibility in the face of the unexpected – was at the heart of the jury’s concerns in this cycle of the award.”

    As well as environmental justice, the built environment is well placed to help solve issues of social justice, His Highness explained in his address: “It is not an exaggeration to say that affordability of our housing, ease of access to green space, education, health and cultural heritage all hinge on the creativity of our architects and the wisdom of our civic planners.”

    Buildings, he added, have the power to raise living standards, inspire reverence and solve problems for generations to come. “Great architecture,” he went on to say, “has the power to answer directly to the most acute development challenges, and to create the inclusive, safe, dignified world that we want for everyone.” Read His Highness the Aga Khan’s speech.

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  • NASA Spaceline Current Awareness List #1,166 12 September 2025 (Space Life Science Research Results)

    NASA Spaceline Current Awareness List #1,166 12 September 2025 (Space Life Science Research Results)

    The abstract in PubMed or at the publisher’s site is linked when available and will open in a new window.

  • Rithidech K, Mohallem R, Aryal UK, Peanlikhit T, Crucian B.Effects of the space environment and re-adaptation to Earth’s gravity on astronauts’ plasma proteome.Life Sci Space Res. 2025 Sep 9. Online ahead of print.PI: K. RithidechNote: ISS results.

    Journal Impact Factor: 2.8

    Funding: “This research was supported by the National Aeronautics and Space Administration (NASA) Grant # NNX16AH80G, awarded to Dr. Rithidech. Proteomic analysis was performed at the Purdue Proteomics Facility, Bindley Bioscience Center. The authors wish to thank the International Space Station astronauts who participated in this study. The authors thank the NASA Human Research Program, Human Health, and Countermeasures Element for the selection and support of this investigation.”

  • Crucian B, Diak DM, Garbino A, Gutierrez C, Bustos-Lopez S, Colorado A, Young M, Smith SM, Zwart SR, Oswald TM, Hew-Yang MY, Estep P, Marshall-Goebel K, Mehta S.Effects of hypoxia/hyperoxia exposure on immune function – Results from a spacecraft-relevant hypobaric chamber study.Front Physiol. 2025 Sep 8;16:1637834.Note: This article and an article below (Gorini Pereira et al.) in the “Other” section are part of Research Topic “Bioconvergence: A New Frontier for Understanding and Enhancing Human Adaptations to Extreme Environments” (https://www.frontiersin.org/research-topics/68632/bioconvergence-a-new-frontier-for-understanding-and-enhancing-human-adaptations-to-extreme-environments). Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.

    Journal Impact Factor: 3.4

    Funding: “The author(s) declare that financial support was received for the research and/or publication of this article. The overall chamber study as a Program level evaluation was funded by the NASA JSC Extravehicular Activity and Human Surface Mobility Program. This included the immunological sub-study, for all immediate analyses. Additional funding for analysis of all frozen biosamples was provided by the NASA Human Research Program, Human Health and Countermeasures Element.”

  • Rhoades J, Mangle K, de León P, Crisman K, Manyapu K.Study on parastronaut ingress and egress of Orion and Boeing CST-100 starliner space vehicles.Acta Astronaut. 2025 Nov;236:904-13.Note: From the abstract: “This preliminary investigation aimed to observe individuals with disabilities participating in the ingress and egress procedures of Lockheed Martin’s Orion and Boeing’s CST-100 Starliner spacecraft.”

    Journal Impact Factor: 3.4

    Funding: “The National Aeronautics and Space Administration funded this project. Grant Number: 22-NUP2022-0061; UNSOL_FY2022.”

  • Tays GD, McGregor HR, De Dios YE, Mulder E, Bloomberg JJ, Mulavara AP, Wood SJ, Seidler RD.Thirty minutes of daily artificial gravity does not mitigate head down tilt induced brain activity changes during cognitive task performance.Front Neurol. 2025 Aug 26;16:1602104.PI: R.D. SeidlerNote: This article is part of Research Topic “Impact of Vestibular Dysfunction Studies on Space Flight Health Challenges” (https://www.frontiersin.org/research-topics/53190/impact-of-vestibular-dysfunction-studies-on-space-flight-health-challenges). The Research Topic also includes articles from previous Current Awareness Lists #1,075 https://doi.org/10.3389/fneur.2023.1284029, #1,139 https://doi.org/10.3389/fneur.2025.1556553, and #1,164 https://doi.org/10.3389/fneur.2025.1628938. This article may be obtained online without charge.

    Journal Impact Factor: 2.8

    Funding: “This work was supported by grants from the National Aeronautics and Space Administration (NASA 80NSSC18K0783) to RS, AM, SW, and JB. During the completion of this work GT was supported by the University of Florida’s (UF) Graduate Student Funding Award and by NIH T32-NS082128.”

  • Pham J, Isquith J, Balaian L, Nandi SP, Engstrom C, Mack K, van der Werf I, Chang P, Stoudemire J, Ladel L, Klacking E, Ruiz A, Chilin-Fuentes D, Sneifer J, Mays D, Gamble P, Giza S, Janowitz J, Nienaber T, Mishra T, Khachatrian AA, Molina E, Snyder MP, Morris SR, Clements T, Muotri AR, Whisenant T, Alexandrov LB, Jamieson CHM.Nanobioreactor detection of space-associated hematopoietic stem and progenitor cell aging.Cell Stem Cell. 2025 Sep 4;32(9):1403-20.e8.Note: This article may be obtained online without charge.

    Journal Impact Factor: 20.4

    Funding: “…This work was supported by the Sanford Stem Cell Institute, the SCRM microscopy core, and the NGS Core Facility of the Salk Institute. We are grateful to our funding agencies for their vital support, including NASA (NRA NNJ13ZBG001N) to UC San Diego Sanford ISSCOR Center, NIH (R01CA296974), NCI (R01CA2 05944), NIH/NIDDK (R01DK114468-01), NIH NCI CCSG p30CA023100, NIH NCI CCSG: P30 CA01495, NIH NIA San Diego Nathan Shock Center (P30 AG068635), the Chapman Foundation and the Helmsley Charitable Trust, LLS Blood Cancer Discoveries, Koman Family Foundation, JM Foundation, and Moores Family Foundation.”

  • Sakharkar A, Chen R, LeRoy E, Nelson TM, Proszynski J, Kim J, Park J, Arikatla MR, Mathyk B, Mason CE.Multi-omics profiling of individuals sustaining extreme physical stressors.Life. 2025 Sep 1;15(9):1377.PI: C.E. MasonNote: This article is part of Special Issue “Space Medicine Advancements: From Human Health to Biomedical System Design” (https://www.mdpi.com/journal/life/special_issues/P9T6CD6J32) and may be obtained online without charge.

    Journal Impact Factor: 3.4

    Funding: “The National Institutes of Health (U54AG089334), NASA (80NSSC23K0832), The UK Cancer Grand Challenges (SAMBAI-01), and the Leukemia and Lymphoma Society (MCL7001-18, LLS 9238-16, 7029-23/22).”

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  • How a Novel Coaching Intervention Is Building Resilience and Hope in Adolescents and Young Adults With Advanced Cancer

    How a Novel Coaching Intervention Is Building Resilience and Hope in Adolescents and Young Adults With Advanced Cancer

    Each year, nearly 90,000 adolescents and young adults (AYAs; aged 15–39) are diagnosed with cancer, and approximately 9,300 die of the disease.1 And although the 5-year survival rate among these young patients is approaching 80%, it lags behind that of the pediatric population, whose 5-year survival rate is approximately 85%.2 In addition, outcomes have remained stagnant for many AYA cancer diagnoses, including sarcomas and central nervous system (CNS) tumors.3 Furthermore, AYAs are at increased risk for developing adverse long-term side effects from cancer and/or its treatment, including chronic conditions, secondary cancers, infertility, poor psychosocial health, and financial toxicity.

    For AYAs with advanced cancer, the emotional and physical toll of the disease can be especially daunting and may include fatigue, pain, and difficulty sleeping, significantly impacting their quality of life; disruptions in critical developmental life milestones, exacerbating feelings of sadness, anxiety, and social isolation; and psychological challenges, including heightened levels of depression and fear of cancer recurrence.

    The findings from a recent randomized phase III clinical trial investigating a novel resilience coaching intervention for AYA patients with advanced cancer are showing promising results in improving feelings of resilience and hope, as well as longer-term improvement in quality of life for these patients.4 The study, conducted by Abby R. Rosenberg, MD, MS, MA, Chief of Pediatric Palliative Care at Dana-Farber Cancer Institute and Director of Palliative Care at Boston Children’s Hospital, and colleagues, tested the Promoting Resilience in Stress Management in Advanced Cancers (PRISM-AC) intervention compared with standard pediatric psychosocial usual care. It focused on 195 AYAs (aged 12–24) diagnosed in the previous 2 weeks with advanced cancer, defined as progressive, recurrent, refractory, or with a less than 50% expected overall survival. Among the trial participants, 37% were diagnosed with leukemia or lymphoma, 42% had solid tumors, and 21% had CNS tumors.

    The patients in the PRISM arm…continued to see improvements in their mental health and quality of life over the next year.

    — ABBY R. ROSENBERG, MD, MS, MA

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    The PRISM-AC program consists of four core sessions delivered by a lay coach and targets AYA-endorsed “resilience resources,” including skills in stress management, goal setting, cognitive reframing, and meaning-making. It also includes a family meeting during which patients can share what helped to reinforce these skills, plus an optional session focused on elements of advance care planning, such as communication preferences and priorities. The participants completed surveys at baseline and at 3, 6, 9, and 12 months after enrollment.

    The results showed that at 3 months, the PRISM-AC intervention group reported significantly improved resilience and hope compared with the patients who received usual care, although there were no significant differences in quality of life, anxiety, or depression. As the study continued, however, the PRISM-AC participants reported progressive improvements in quality of life and anxiety compared with the usual-care group. And by 9 to 12 months, the intervention group also appeared to participate more in key health-care decisions.4

    In a wide-ranging interview with The ASCO Post, Dr. Rosenberg discussed the psychosocial impact of cancer on AYA cancer survivors, the results of the PRISM-AC study, and how AYA survivors are able to cope with having a terminal prognosis.

    Understanding the Consequences of Cancer on AYAs

    Before we discuss the findings from your PRISM-AC study, please explain the psychosocial impact of cancer on AYA cancer survivors.

    We are continuing to learn about the consequences of cancer on AYAs. What we know is that for these young survivors, a cancer diagnosis interrupts their critical developmental life stages, impacting their physical, psychosocial, and emotional well-being. This disruption may impact their identity formation, social relationships, education, and professional career as well as hinder their transition to adulthood and becoming independent. They may have fewer opportunities for career advancement, make less money, and have a more difficult time building social relationships.

    That doesn’t mean these young survivors are not resilient. They often still lead incredibly happy and meaningful lives. To me, the key consideration is that the stressors of having cancer at this age compared with at an older age are enormous. I want to find ways to make the diagnosis less hard.

    Thriving During Survivorship

    Please talk about the PRISM skills-based coaching program, which comprises four 30-to-60-minute, one-on-one sessions, plus a facilitated family meeting. What is discussed at these sessions?

    In its original form, the PRISM program included the four core sessions plus the optional meeting with the family and a coach. Those core sessions were developed in partnership with AYAs over a decade ago and are based on what they told us was important to them. For example, learning stress management techniques, such as deep breathing and mindfulness, is the focus of the first session. The second session is on setting specific, measurable, actionable, and realistic goals. The third session emphasizes cognitive reframing, a technique that helps patients reappraise how they perceive and react to stressful situations. And the fourth core session centers around helping people identify what matters most to them and what they are grateful for even in hard times.

    All of these skills have been validated as helpful in coping with stress and adversity. What we’ve learned from previous studies among AYAs with newly diagnosed cancer is that delivering all four of these sessions in a reproducible, lay-coach setting—with or without the facilitated family meeting—translates to improvements in resilience, hope, quality of life, and psychological distress when compared with usual care.

    Together, both AYAs and their parents are struggling, and advance care planning provides an opportunity to help.

    — ABBY R. ROSENBERG, MD, MS, MA

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    Perhaps more relevant to this recent PRISM-AC trial was this: AYAs who received the PRISM intervention and then experienced a relapse or disease progression told us they wanted even more PRISM sessions. Specifically, they said the PRISM intervention helped them set goals and identify what mattered most to them, and now they needed help applying those skills to talk to their family and clinicians about treatment choices and preferences for end-of-life care.

    I listened to those comments and thought what these patients are asking for is essentially the same service we offer in palliative care, which is advance care planning. So, in the current PRISM-AC study, in addition to the four core sessions and the family meeting, we included a sixth module that integrated concepts in advance care planning to help AYAs with advanced cancer set goals and make their wishes known for their end-of-life care.

    Building Feelings of Resilience and Hope in AYAs

    Your results from the PRISIM-AC study showed that at 3 months, participants reported significantly improved resilience and hope than AYAs receiving usual care, but there were no significant differences between study arms in terms of quality of life, anxiety, or depression. However, there were significant improvements in quality of life, depression, and anxiety in the PRISM group at 6 and 12 months, and as more time went by, AYAs participated more in their key health-care decisions. Please talk about this finding. And how old were the AYAs who felt more comfortable in their health-care decision-making, including end-of-life care?

    What the study results showed is that the AYAs who received the intervention experienced immediate improvements in their feelings of resilience and hope. What I suspect, and we don’t know this for sure, is that as time went on, these AYAs continued to hone those skills. That’s why we saw the continued impact of those skills at 6, 9, and 12 months.

    What is really important from the findings of this study is that at 6, 9, and 12 months, the patients in the usual-care arm of the study had scores that bounced all over the place. What that tells me is these patients were still struggling with their cancer diagnosis, and they had some good and bad days. But the patients in the PRISM arm had developed a more stable foundation in their resilience and hope skills, and that’s why they continued to see improvements in their mental health and quality of life over the next year.

    In terms of age, on average across both groups, patients were about 16.5 years old. What we found after looking through palliative care notes in patients’ medical records is that over time, AYAs in the PRISM group were more likely to directly participate in their clinical care and share their opinions about that care, whereas the AYAs in the usual-care group often continued to defer to their parents for treatment and end-of-life care decision-making.

    Understanding Prognosis

    All AYAs in the study had advanced cancer. How were these young patients able to come to terms with having a terminal disease at such a young age?

    This is such an important question, but we did not ask that question explicitly in this study. What we know about pediatric and AYA patients is that they very often understand their prognosis and the concept of death. We know that children with terminal illnesses who are as young as 8 years old understand they are likely to die of their disease.

    Brandon Hayes-Lattin, MD, FACP

    Brandon Hayes-Lattin, MD, FACP

    Brandon Hayes-Lattin, MD, FACP, is Professor of Medicine, Deputy Division Head of Hematology and Medical Oncology, and Director of the Adolescent and Young Adult Oncology Program at the Knight Cancer Institute at Oregon Health and Science University, Portland.

    What we also know is that young individuals, and AYAs in particular, tend to want to protect their loved ones from these difficult conversations. They rarely admit out loud that they know they are going to die. Instead, they are more likely to verbalize their hopes, for example, that the next medicine will work, that God will help them, or that they will defy the odds.

    What is impressive about caring for these young patients, in addition to their incredible sense of resilience and hope, is they articulate their prognostic understanding in a slightly different way from older adults. For example, rather than saying, “I know I’m going to die and my time is short,” they may say, “I really want to be home with my family and my dog,” or “I’m engaged to be married, and it’s important for me to get married now rather than wait.” They will make these poignant comments from which you can intuit that they understand their prognosis.

    What’s especially touching about this situation is that parents also want to protect their children, and so they often avoid the hard talks in an effort to prevent additional distress. Together, both AYAs and their parents are struggling, and advance care planning provides an opportunity to help.

    It is such a privilege to care for these incredible people.

    DISCLOSURE: Dr. Rosenberg reported no conflicts of interest.

    REFERENCES

    1. Miller KD, Fidler-Benaoudia M, Keegan TH, et al: Cancer statistics for adolescents and young adults, 2020. CA Cancer J Clin 70:443-459, 2020.
    2. Janardan SK, Wechsler DS: Caught in the in-between: Challenges in treating adolescents and young adults with cancer. JCO Oncol Pract 17:299-301, 2021.
    3. Itzep N, Roth M: Psychosocial distress due to interference of normal developmental milestones in AYAs with cancer. Children (Basel) 9:309, 2022.
    4. Rosenberg AR, Fladeboe KM, Zhou C, et al: Promoting resilience in stress management: A randomized controlled trial of a novel psychosocial intervention for adolescents and young adults with advanced cancer. JCO Oncol Pract. April 28, 2025 (early release online).

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