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  • Why England May Ban Energy Drinks for Under‑16s

    Why England May Ban Energy Drinks for Under‑16s

    LONDON — Ever been ID’d when buying a can of Red Bull? That’s what the future may hold for teenage consumers of energy drinks in England.

    U.K. health secretary Wes Streeting announced a consultation on banning those under the age of 16 from purchasing energy drinks that contain more than 150 milligrams of caffeine per liter. Energy drinks that currently breach that limit include those sold by the likes of Red Bull, Monster and Prime. 

    Ministers say a ban would prevent issues associated with young people consuming energy drinks, such as disrupted sleep, increased anxiety and lack of concentration, along with poorer school results. 

    But why is it that those ages 15 and under are being targeted by ministers? Deborah Gater, assistant professor in chemistry at Northeastern University in London, says it’s because caffeine can have a more disruptive effect on young, developing bodies.

    Explaining how caffeine disrupts natural sleeping patterns, Gater says caffeine, which is also found in tea, coffee and soft drinks such as Coca-Cola, tricks the brain into thinking it is not tired.

    In simple terms, Gater says the caffeine molecule is “structurally like” the chemical adenosine, which is what gradually builds up to indicate to your brain that it is time for sleep. Caffeine confuses the brain’s adenosine receptors and “gets in the way” of the chemical from binding properly, deceiving the brain into staying alert for longer.

    If your body begins to get used to regular caffeine use, it can “mess with your sleep-wake patterns,” Gater adds. This then has a impact on things like a person’s ability to control dopamine levels and the way the nervous system regulates itself, which can, in turn, make it hard to concentrate and can also cause anxiety.

    Deborah Gater, assistant professor in chemistry (left), and Dina Rabie, assistant professor in economics, analyse the potential energy drinks ban. Courtesy photos

    For children, their smaller body size makes these effects more pronounced, adds Gater. 

    A 12-ounce can of Prime Energy contains 200 milligrams of caffeine, compared with 114 in the same size serving of Red Bull. Scientists say a can of Prime Energy is equivalent to drinking two shots of espresso, with the average cup of coffee containing at least 80 milligrams of caffeine. Coca-Cola and similar soft drinks have between 35 and 45 milligrams of caffeine in a 12-ounce can.

    Pediatricians, according to a report by The New York Times, recommend that children under the age of 12 avoid caffeine entirely, and that those from 12 to 18 should consume no more than 100 milligrams per day.

    “The issue with kids, particularly, is twofold,” says Gater. “Kids, in the main, are smaller than adults. Particularly when you’re talking about 10-, 11- and 12-year-olds, if they’re only 40-50 kilograms (88-110 pounds), then in terms of milligrams of caffeine per kilo of bodyweight, a cup of coffee that is just a nice hit for an adult is going to completely overwhelm their system in terms of how much caffeine is floating around.

    “And then the secondary thing is, because they’re still developing and they’ve got all these receptors interacting and sending signals to each other, nobody is quite sure what the long-term effect is — or even necessarily the acute effect — of giving small children with developing brains and bodies large quantities of caffeine.”

    Despite the effect of caffeine intake on pubescent teens not being entirely understood, high school-aged children in the U.K. are commonly purchasing energy drinks. In the government consultation on the ban, ministers cite research showing that, between 2013 and 2018, one-third of children aged 13 to 16 consumed one or more high-caffeine energy drinks each week.

    In the U.S., the use of energy drinks among adolescents has been described as “widespread.”  According to research from 2014 shared by the National Library of Medicine, nearly two-thirds of American teens reported having used energy drinks.

    European countries such as Latvia and Lithuania have already banned the sale of energy drinks to children, and the U.K.’s Labour government wants England to follow their lead.

    Assistant professor Dina Rabie, a behavioral economist on Northeastern’s London campus, says there are clear benefits to such bans. She says when hyper schoolchildren become disruptive in the classroom and elsewhere, the damage that causes reaches far beyond the individual.

    “It is not just the person drinking who is being affected,” she says. “There are external effects on others and, in that case, there could be external costs.”

    Rabie stresses, however, that applying a ban is not enough to prevent the consumption of energy drinks appearing attractive to young people. She argues that schoolchildren should be taught about the harmful effects energy drinks can have so they are not incentivized to take up drinking such products as a social rite of passage when turning 16.

    “It is really important that with the ban comes the education about what the ban is for,” Rabie continues.

    “It is important for the kids to know why this is not good for them. It is about being aware that this has lots of negative effects on you and on others. It is important to do this so that when the person becomes 16, they don’t just go and drink and show off that they have more energy to their classmates. Without that awareness campaign, this policy could backfire.”

    Major supermarkets in Britain have already voluntarily stopped sales of the drinks to young people but the proposal, if it is implemented, would make it a legal obligation for retailers to check consumers are old enough to purchase cans of Red Bull, Monster and similar products.

    British ministers are no strangers to considering potential bans in the name of public health. Former Conservative prime minister Rishi Sunak wanted to outlaw smoking in future generations and the current Labour government is set to bring in a blackout on junk food advertising aimed at children.

    Such interruptions to the way markets operate are a “paternalistic” form of governing, Rabie says, but she argues that it can be justified if a certain type of consumer behavior “poses some risk” to the nation’s wellbeing.

    A ban could, she suggests, lead to better options for consumers. It could force producers of energy drinks to create alternatives that do not have as many associated health risks.

    “Energy drink companies may start to come up with healthier solutions,” she says. “Companies could respond by protecting young people and by offering substitutes — drinks that are lower in sugar and lower in caffeine.”

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  • Owen Cooper’s Emmy sends message to ‘look outside the box’, drama school says | Adolescence

    Owen Cooper’s Emmy sends message to ‘look outside the box’, drama school says | Adolescence

    The co-director of the drama school where Adolescence star Owen Cooper trained has said she hopes his Emmy win will encourage producers to “look outside the box” when it comes to casting working-class and northern talent.

    Cooper, 15, became the youngest ever male recipient of an Emmy on Sunday, when he won the best supporting actor in a limited series award for his role as the teenage murder suspect Jamie Miller in the Netflix drama.

    Esther Morgan, who runs the Drama MOB school in Didsbury, Manchester, with the Coronation Street star Tina O’Brien, helped train Cooper alongside hundreds of other young people from the north-west from a wide variety of backgrounds.

    She said they were delighted at his success and pleased to see the producers taking the time to look for talent outside London.

    “There’s a frustration in the industry that everything seems to happen in London, despite the talent that exists elsewhere,” Morgan said. “We were really passionate that we wanted to build something from the north, for northern kids and provide them with the same opportunities, no matter where they’re from.”

    Cooper was cast in Adolescence after Stephen Graham, who co-created and starred in the series as the father of Cooper’s character, insisted on casting an unknown northern actor for the role. Graham has previously said he and the production team wanted to give a chance to young people “who may not normally have those opportunities” and that doing so was the show’s biggest achievement.

    Morgan said: “We’re so proud of Owen and so happy for him, and he’s worked so hard, and we’re delighted that the producers took the time to look for northern talent and took a chance on him. But it’s so rare they’ll take that chance, and so much talent is never looked at.”

    Morgan hopes that Cooper’s win will motivate more young people in the north-west to give the arts a try, and encourage a broader approach to casting that will enable people outside the capital, especially younger people, to be put on an equal footing for roles in the future.

    “You hope now that with the story of Owen, who you know, is just a normal kid from Warrington, more people will consider sending their kids to the school,” Morgan said. “What we really want, and what we hope Owen’s success does, is give a bit of a message out to everybody that maybe there is some really good raw northern talent out there, and in the rest of the country. Maybe come and look in different places in future to find that talent; maybe you’ll find a star.”

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    The Drama MOB school offers students a range of options, including the possibility of attending for nothing, so that young people can access the arts regardless of household income to “bridge that gap and make sure that it is accessible to everybody”.

    In the past, Morgan has lamented the way talent outside the south is viewed, saying casting directors and producers have rarely given talent in other parts of the UK a chance even when a production is based there, and that when an actor such as Cooper is cast, there is a narrative that they have “done nothing and came from nowhere” despite being trained.

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  • Lachlan Morton’s top tips for cycling in the dark

    Lachlan Morton’s top tips for cycling in the dark

    Tips & Recipes

    Ultracycling legend sheds light on how stay safe and have fun on the bike at night

    September 16, 2025

    Lachlan Morton has advice for you if you want to ride bikes in the dark.

    Lachy has done more than his fair share of nighttime riding on long-distance adventures like the Alt Tour, One Ride Away, The Divide, and Great Southern Country. He has made all the mistakes, scared himself more than a few times, and figured out the hard way what works best for riding in the dark.

    Ultra-distance racing, FKTs, and audax events are becoming evermore popular — and riding at night is often part of the game. It can also be dangerous, especially on open roads.

    We asked Lachlan for his best nighttime riding tips, so you can stay safe and have fun on the bike at night.

    1. Use powerful lights

    I very quickly learned that it is a massive advantage to be able to see the road, or trail. You save so much mental energy when everything is well-lit. Especially if you are riding off-road at night, I would say go with high lumens and lots of battery.

    Knog has a 1300-lumen Blinder that I put under my Wahoo. That works really well, because I can just leave it on the bike all the time. They also have a super high-powered, 2300-lumen big dog that is great for absolutely lighting it up. You can toggle through the different brightness modes. Basically, if you’re going uphill or if it is less technical, you can run it lower and then when you need it, you just crank it up. Get good lights.

    2. Wear a headlamp

    I always wear a headlamp at night. It helps to be able to light up the trail where you’re looking, as well as where the bars are pointing. And then, if you’re trying to get something out of a bag or you stop to pee, it’s helpful to always have the headlight. So, as soon as it gets dark, the headlight goes on. That doesn’t mean I’m always running it, but it is good to have the combo ready.

    3. Have a sleep strategy

    Managing sleep is super important. I’ve done it both ways in ultra events, pushing through the nights and dedicating time to sleep, and I definitely now prefer to sleep. For me, if I’m getting five hours, I think it is a good amount. That way, you at least get a full sleep cycle. There’s always half an hour or so on each side for setting up and packing up. For keeping the stress down, sleep is super important. You know: I’ll get the sleep and then I’ll be better for it.

    What I do is try and work out during the day how I’m traveling and then get an idea that I could get to “spot X,” whether it’s a town or a campground or somewhere else I like that would be a good spot to set up. That helps you stay focused until you get to that point, as opposed to just riding until you get tired. I prefer to do it that way.

    4. Listen to your body and don’t push through extreme fatigue

    Even though I have ridden through whole nights, I wouldn’t advocate for it. If you do plan to do it, knowing yourself becomes very important, because you can switch really quickly from feeling really good to feeling like, “Oh, I’m in a hole, and I need to stop right away.”

    Gauging when you need to stop is key. You need to work out your own cues for when you’re getting tired. Sometimes, because you’re very stimulated, they can be hard to read, but you need to work out what those cues are and when to call it a night.

    Sometimes, it’s just a lack of focus and concentration, which, if you’re riding off road, is really easy to pick up because you get sloppy and make mistakes. On the road, it is a little harder to work out, but, in general, it is a focus thing and once your mind starts to wander, you should call it a night. You’re better off calling it early than finding yourself pushing a bit too far and then being stuck somewhere and being really tired all of a sudden and having to work it out at that point.

    5. Be extra careful around traffic

    Being careful around traffic is a huge one. The nice thing is that if you have good lights, you should actually be more visible at night, because you really stand out. Make sure you get the lights on early, because twilight, the hours between when the sun starts to go down and complete darkness, is probably the most dangerous time. It’s also when there tends to be a lot of cars.

    You have to be aware that people who are driving at strange hours might also be tired. During the day, you might not think twice about a car overtaking you, but if it is 2:00 AM and you’re riding along a random road, check to make sure that they have seen you.

    As a bike rider, it is on you to look after your own safety a little bit more at night, because no one’s expecting to see you. If you are in a city, coming through a town where there are blind corners, or where traffic merges, it is definitely important to bring it back a notch and make sure that the drivers have seen you. If someone’s pulling out of a street at 11 o’clock at night, they’re probably not expecting to see you. That doesn’t mean there’s any malintention behind it. It’s just human nature, so having that awareness is key. I don’t think that riding at night is necessarily any more risky than riding in the daytime. But, with traffic, it is on you as a bike rider to ensure your safety, because you are always going to come off second best in a crash.

    6. Keep important gear close

    One thing you can easily underestimate at night is managing things like clothing. Little things become a lot more difficult when it’s dark. Once I know I’m going into the night, I’ll stop and tell myself, “I might need this, so I’ll get it out of my bag now and put it in my pocket.” Or, I might just chuck on a vest then and leave it open. When you switch to night mode and it’s dark, you want everything to be as simple as it can be and have everything you need right there, so you don’t waste time looking for it, because all of that becomes 10 times more difficult in the dark.

    7. Embrace the dark

    Night riding, especially if you’re with a group of people out on a casual night ride, can be so fun, because you can ride roads or terrain that you’ve done a hundred times before, but at night they are completely different. If you haven’t done it, I would say, go and do it. It feels a little naughty, like you are out too late, or something. It is a really fun thing to go and do. Just stay safe.

    Check out Lachlan’s favorite Knog bike lights.

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  • A Galaxy Warped by Gravity Glows With Baby Stars

    A Galaxy Warped by Gravity Glows With Baby Stars

    Hubble’s latest portrait of Messier 96 captures a galaxy twisted by cosmic interactions. The new details reveal brilliant star-forming regions glowing in its outer edges. Credit: ESA/Hubble & NASA, F. Belfiore, D. Calzetti

    Messier 96, a spiral galaxy 35 million light-years away, shines with a lopsided beauty shaped by cosmic forces.

    Its uneven arms, displaced core, and scattered gas clouds hint at gravitational struggles with nearby galaxies.

    Galactic Tug of War in Leo

    This striking image from the Hubble Space Telescope showcases a galaxy with an unusual, lopsided appearance that may be the result of a cosmic struggle between neighboring galaxies. Known as Messier 96, the spiral galaxy lies about 35 million light-years away in the constellation Leo and is the brightest member of its galactic group. Astronomers believe that the gravitational influence of surrounding galaxies could explain Messier 96’s uneven arms, scattered gas and dust, and its core that sits slightly off-center.

    Hubble’s Ongoing Observations of Messier 96

    The galaxy’s distorted shape is vividly captured in Hubble’s newest portrait, created from ultraviolet and optical observations. This is not the first time Hubble has turned its gaze on Messier 96, with earlier images released in 2015 and 2018. Each release has built upon the last, gradually layering new details to create both a visually stunning and scientifically rich record of the galaxy.

    A New Look at Star Formation

    The latest image adds a new dimension to our understanding of how stars are forming within Messier 96. Bright pink clouds of gas encircle clusters of massive, young stars, outlining a glowing ring of stellar birth on the galaxy’s outer edges. Many of these newborn stars remain nestled in the very gas clouds that created them. For the first time, astronomers now have access to new data from this image that will help them explore how stars emerge from dense clouds of dust and gas, how dust alters the light we see from stars, and how the stars themselves reshape their galactic environment.

    Never miss a breakthrough: Join the SciTechDaily newsletter.

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  • Qatar, US near defence deal after Israeli strike in Doha – Reuters

    1. Qatar, US near defence deal after Israeli strike in Doha  Reuters
    2. Rubio in Qatar after warning of ‘short window’ to secure Gaza ceasefire  Al Jazeera
    3. Rubio promises ‘unwavering support’ to Israel in Gaza goals  Dawn
    4. Rubio says Netanyahu has full support of US over plans to destroy Hamas  The Guardian
    5. Rubio, in Israel, Says a Diplomatic Solution to Gaza War May Not be Possible  The New York Times

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  • Nusantara Lima Satellite to provide internet services throughout Indonesia and ASEAN, Access Evolution

    Nusantara Lima Satellite to provide internet services throughout Indonesia and ASEAN, Access Evolution

    Jakarta – PT Pasifik Satelit Nusantara, Indonesia’s first private satellite company, successfully launched the Nusantara Lima Satellite (SNL) into orbit aboard a Space Exploration Technologies Corporation (SpaceX) Falcon 9 rocket from Cape Canaveral, Florida, United States, on Thursday (September 11) local time, after three launch delays due to unfavorable weather. SNL is a 160 Gigabit per Second (Gbps) satellite, the largest in Asia, capable of providing internet access throughout the Indonesian archipelago, including the Philippines and Malaysia.

    The SNL launch was witnessed by Wayan Toni Supriyanto, S.T., M.M., Director General of Postal and Informatics at the Ministry of Communication and Digital, as well as all partners and stakeholders participating in the project. This satellite will play a crucial role in strengthening national capacity for the domestic market, equitable internet access, developing telecommunications technology, strengthening space-based human resources, disaster mitigation, environmental monitoring, and the defense and security sector.

    PSN President Director Adi Rahman Adiwoso stated that the successful launch of the SNL further strengthens Indonesia’s capabilities and credibility as a key player in the global space industry. This success demonstrates Indonesia’s ability to create internet-based service infrastructure and provides momentum for developing a national space industry roadmap. This will accelerate Indonesia’s goal of becoming a sovereign nation capable of independently managing space.

    “We express our gratitude for the hard work and strong collaboration between PSN, Boeing Satellite System International Inc., and SpaceX, as well as the strong support from the Indonesian government, which enabled the SNL launch to proceed smoothly and as planned. In the spirit of celebrating 80 years of independence, we hope that the SNL will have a significant impact on various aspects of life and support the Indonesian government in realizing space sovereignty,” Adi Rahman said in an official statement.

    The SNL launch was scheduled for Monday (September 8th) local time. However, in accordance with standard operating procedures, the launch had to be postponed due to non-technical factors, including rain and lightning. The SNL launch was rescheduled for Tuesday (September 9th), but the weather remained unfavorable, leading to a second postponement. On the third day, the rocket was declared unable to launch due to unfavorable weather and minor technical issues with the rocket. The fourth SNL launch attempt was conducted on Thursday (September 11).

    Adi Rahman explained that launch delays are common in space missions, as many important factors must be considered during the launch process. “The decision to postpone is based on SpaceX’s evaluation results. PSN fully supports SpaceX’s decision to ensure the safety of all systems and the success of the SNL launch mission. Overall, the Nusantara Lima Satellite is in prime condition and on track to reach its orbit,” said Adi Rahman.

    SNL is a Very High Throughput Satellite (VHTS) satellite, enabling greater bandwidth capacity to provide broadband services to all corners of Indonesia and ASEAN countries, namely the Philippines and Malaysia. The 7.8-ton satellite is equipped with a hybrid propulsion system using Xenon-Ion (XIPS) chemical and electronic propulsion, which is ten times more efficient than conventional satellites, and 101 spot beams operating at the Ka-band frequency.

    To support the operation of Asia’s largest-capacity satellite, PSN is collaborating with Hughes Network System to build eight earth stations across several cities, including Banda Aceh, Bengkulu, Cikarang, Gresik, Banjarmasin, Tarakan, Kupang, and Makassar. Satrio Adiwicaksono, Project Director of Satelit Nusantara Lima and PSN Technology Director, added that the distribution of earth stations across Western, Central, and Eastern Indonesia allows SNL services to reach the Underdeveloped, Frontier, and Outermost (3T) regions that have traditionally struggled to access the internet.

    “PSN believes that easy access to the best internet services is a right for all Indonesian citizens amidst the current rapid digital transformation. We hope that the presence of PSN services can be a catalyst in improving the quality of life for the community and contribute to supporting the progress and prosperity of the Indonesian nation,” said Satrio.

    SNL will spend four to five months in space, eventually occupying an orbital slot at 113 degrees East Longitude. After reaching orbit, PSN will conduct three weeks of In-Orbit Testing to ensure all SNL equipment is functioning normally after launch. The final stage, PSN will conduct an In-Orbit Acceptance Review (IOAR) to ensure that SNL and other supporting infrastructure (ground segment), such as eight ground stations and other communication networks, have been integrated, tested, and are functioning properly.

    SNL Services Reach ASEAN

    With its large capacity, SNL can also provide services to the Philippines and Malaysia. Adi Rahman stated that PSN established a partnership with satellite service company We Are IT Philippines Inc. in late 2022. PSN will help provide internet connections in remote areas of the Philippines with a capacity of 13.5 Gbps. Providing services to ASEAN will also strengthen the company’s and the country’s reputation internationally.

    “The expansion of PSN services to ASEAN countries confirms the capabilities of Indonesian companies in satellite and space technology on the global stage. We will continue to innovate our products and services to maximize the potential of other markets in the future, while simultaneously pursuing our mission of strengthening a sovereign and independent national space industry,” Adi Rahman concluded.

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  • TikTok deal to include new investors with ByteDance; Oracle to keep cloud agreement, sources say

    TikTok deal to include new investors with ByteDance; Oracle to keep cloud agreement, sources say

    The upcoming framework agreement for the social media platform TikTok will include new investors as well as existing investors in the platform’s Chinese parent company ByteDance, sources told CNBC’s David Faber.

    The deal is expected to close in the next 30 to 45 days, according to the sources, who asked not to be named because the details of the negotiations are confidential. As part of the agreement, Oracle will keep its cloud deal with the platform, the people said.

    “Where this thing is capitalized and how large it is remains to be seen,” Faber said during CNBC’s “Squawk on the Street” on Tuesday. “‘I’m hearing it’s actually going to be relatively small in terms of the actual size of the checks that are written for the entity itself, and it will not be something that is going to go public at some point.”

    TikTok’s future in the U.S. has been uncertain since 2024, when Congress passed a bill that would ban the platform unless its Chinese owner, ByteDance, divested from it. Lawmakers had grown concerned that the Chinese government could access sensitive data from American users or manipulate content on the platform.

    The new details about the deal come after U.S. Treasury Secretary Scott Bessent said Monday that the U.S. and China have reached a “framework” deal for TikTok. Bessent said Tuesday that commercial terms had been in place since March or April, but the Chinese put it on hold after Trump’s “Liberation Day” tariff blitz.

    The White House, TikTok and Oracle did not immediately respond to CNBC’s request for comment.

    This is breaking news. Please refresh for updates.

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  • Promising New Preclinical Therapy Offers Hope in the Development of Precision Medicine Treatments for Aggressive Cancers

    Promising New Preclinical Therapy Offers Hope in the Development of Precision Medicine Treatments for Aggressive Cancers

    Newswise — Philadelphia September 16, 2025 – Researchers at Children’s Hospital of Philadelphia (CHOP) unveiled a novel antibody-drug conjugate (ADC) that shows striking efficacy against cancers that express the anaplastic lymphoma kinase (ALK) protein on the cancer cell surface. The therapy, named CDX0239-PBD, achieved complete and lasting tumor responses in preclinical models of neuroblastoma, rhabdomyosarcoma and colorectal carcinoma, according to findings published in Nature Communications. The breakthrough could unlock a new class of precision medicine treatments for both childhood and adult cancers, potentially improving short- and long-term patient outcomes and minimizing the harmful side effects of many current treatments.

    Yael P. Mossé, MD, Professor of Pediatrics and leader of the Neuroblastoma Developmental Therapeutics Program at CHOP’s Cancer Center, and her team are renowned for the groundbreaking discovery of gain-of-function mutations in the ALK gene, which are the primary cause of hereditary neuroblastoma and the most common mutations in its sporadic forms. This discovery was pivotal as it identifies ALK as the only mutated oncogene in neuroblastoma that can be targeted for therapy, reducing the likelihood of toxic side effects. The new research, an outgrowth of Mossé’s work, was led by Alberto D. Guerra, MD, PhD, a fellow within the Division of Oncology at CHOP.

    In the study, researchers combined CDX0239, a humanized antibody targeting ALK, with a potent chemotherapy agent called pyrrolobenzodiazepine (PBD) dimer. This innovative approach directs the antibody to cancer cells, delivering the chemotherapy inside to kill cancerous cells while mostly sparing healthy ones that do not express ALK. The ADC remained stable in the bloodstream, an essential step for moving the research into human trials.

    “Our findings represent an important advance in the field of antibody-drug conjugates for pediatric solid tumors, an area where progress has lagged,” said Guerra. “By combining tumor selectivity with potent drug delivery, CDX0239-PBD offers a potential blueprint for future pediatric solid tumor therapies.”

    The therapy’s effectiveness is closely linked to ALK levels on the surface of cancer cells. Those with a range of ALK surface expression responded well, even when expression was modest. This is particularly exciting as these findings credential the opportunity to leverage an ADC approach for a broad population of patients. In preclinical studies with human tumor models, three total weekly doses of CDX0239-PBD successfully eliminated tumors, resulting in 100% survival across several highly drug-resistant preclinical models. The effects were seen not only in pediatric cancers like neuroblastoma and rhabdomyosarcoma but also in colorectal carcinoma, underscoring the treatment’s potential versatility.

    The therapy also achieved success where others did not. For example, in models resistant to lorlatinib, an FDA-approved ALK inhibitor, and those with TP53 mutations and MYCN amplification, treatment with CDX0239-PBD led to lasting positive effects and complete survival. Molecular analyses confirmed that the treatment caused DNA damage and activated cell-death pathways inside tumors, validating its mechanism of action to be selective delivery of a potent chemotherapy drug to cancer cells expressing ALK, and likely also to neighboring tumor cells which may not necessarily express ALK, a phenomenon referred to as the “bystander effect.”

    Moving forward, the research team is working on refining the technology to meet strict regulatory requirements for developing a first-in-class ALK-directed ADC, aiming for first-in-human/first-in-children early phase clinical trial testing within the next two years. The team is also exploring alternative antibodies with features that would allow for better penetration into the solid tumor microenvironment.

    “Precision medicine is transforming our approach to cancer treatment by moving beyond one-size-fits-all therapies,” said Mossé. “By tailoring treatments to the unique characteristics of each tumor, we can specifically target cancer cells, thereby increasing the potency and reducing harmful side effects on healthy cells. Our hope is to significantly boost survival rates for patients fighting aggressive cancers while also enhancing their quality-of-life post-treatment.”

    This work was supported in part by the National Cancer Institute grants (R01CA140198-11-1, R37CA282041 and K08CA230223), Patricia Brophy Endowed Chair in Neuroblastoma Research, DOD Award (W81XWH-12-1-0486), the National Institutes of Health grant (R013208130624), the National Institutes of Health grant (DP2HD108775), funding from Braden’s Hope Foundation, the Margaret Q Landenberger Foundation, NIH Grant (2T32CA009615) and the Howard Hughes Medical Institute (HHMI).

    Guerra et al. “A humanized anaplastic lymphoma kinase (ALK)-directed antibody-drug conjugate with pyrrolobenzodiazepine payload demonstrates efficacy in ALK-expressing cancers.” Nat Comms. Online August 15, 2025. DOI: 10.1038/s41467-025-62979-1

    About Children’s Hospital of Philadelphia  

    A non-profit, charitable organization, Children’s Hospital of Philadelphia was founded in 1855 as the nation’s first pediatric hospital. Through its long-standing commitment to providing exceptional patient care, training new generations of pediatric healthcare professionals, and pioneering major research initiatives, the hospital has fostered many discoveries that have benefited children worldwide. Its pediatric research program is among the largest in the country. The institution has a well-established history of providing advanced pediatric care close to home through its CHOP Care Network, which includes more than 50 primary care practices, specialty care and surgical centers, urgent care centers, and community hospital alliances throughout Pennsylvania and New Jersey. CHOP also operates the Middleman Family Pavilion and its dedicated pediatric emergency department in King of Prussia, the Behavioral Health and Crisis Center (including a 24/7 Crisis Response Center) and the Center for Advanced Behavioral Healthcare, a mental health outpatient facility. Its unique family-centered care and public service programs have brought Children’s Hospital of Philadelphia recognition as a leading advocate for children and adolescents. For more information, visit www.chop.edu

     

     

     

     

     

     


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  • What to Read During Jane Austen’s 250th Birthday Year

    What to Read During Jane Austen’s 250th Birthday Year

    This year marks the 250th anniversary of Jane Austen’s birth. While the precise day is December 16, the book world has been marking the occasion all year with homages, story spin-offs, new editions of her novels and celebrations, including a massive 10-day Jane Austen festival this month in Bath, England.

    The beloved English novelist, whose stories have launched a million rom-coms, could hardly have imagined the vastness of her influence more than 200 years after she published her stories anonymously — or “by a lady.”

    Austen’s presence can be felt across our entertainment culture, from the Emma-inspired film Clueless (1995) to the 1996 novel (and later, film) Bridget Jones’s Diary, whose plot author Helen Fielding admits she “nicked” from Pride and Prejudice. British writer Ian McEwan has said Austen’s fingerprints are all over his 2001 masterpiece Atonement; her work is “the ghost that stalks this novel,” he once told a French audience. The list of film adaptations and books inspired by her work goes on and on, including Bollywood movies, graphic novels, erotic fiction and monster tales (2009 brought the bestseller Pride and Prejudice and Zombies by Seth Grahame-Smith and Sense and Sensibility and Sea Monsters, a parody by Ben H. Winters).

    Today you can stream Jane Austen Wrecked My Life, a rom-com about a lovelorn, Austen-obsessed bookseller in Paris, and Miss Austen, a four-part PBS miniseries released in May that reimagines the lives of Jane and her sister, Cassandra.  

    Two new film versions of her books are in the works too: Netflix’s upcoming six-part Pride and Prejudice, now in production, stars Emma Corrin (Diana in The Crown) as Elizabeth Bennet, Olivia Colman as Mrs. Bennet, and Scottish actor Jack Lowden as Mr. Darcy. Focus Features is filming a new Sense and Sensibility movie with Daisy Edgar-Jones (Twister) and Esmé Creed-Miles as sisters Elinor and Marianne Dashwood; Outlander’s Caitríona Balfe plays their mother.

    a collage with a portrait of jane austen and a hand holding a quill pen

    Who was Jane Austen?

    Austen, one of eight siblings, was born in 1775 to a clergyman in rural southern England. She began writing stories around age 11, when her formal education ended. Her father always encouraged her to read, offering her full access to his extensive home library, and gave her a portable wooden writing desk for her 19th birthday. When she was 25, her father retired, and the remaining members of her household — the Rev. and Mrs. Austen, Jane and Cassandra — downsized from the roomy rectory to smaller quarters in Bath, a fading resort town.

    After Rev. Austen’s death four years later, Jane, Cassandra, their mother, and a family friend moved into Chawton Cottage, now the Jane Austen House Museum. There, the author revised and wrote her six novels on a tiny, portable writing table. She died at 41 of a mysterious illness.

    Austen scholars say this life was not as dreary as the bare facts suggest: She loved going to London, attending the theater, shopping, taking holidays by sea, where she enjoyed being dunked in the ocean by an old-fashioned bathing machine, and gossip. In a new book, Wild for Austen: A Rebellious, Subversive, and Untamed Jane, Arizona State University professor Devoney Looser expands on instances of the author’s worldliness (Austen once bragged that she was excellent at spotting adulteresses, for example). 

    More reasons to love Jane

    1. She captured the realities of women’s lives — particularly the frustrations of smart, young women whose energies were narrowed to husband-seeking in the refined society of late 18th-century England. As a single woman with almost no career path available, like many ladies in her day, Austen captured how landing a prosperous husband was essential for financial security and social acceptance, often at the expense of love. “[Her books] are about how to live a meaningful life in a world that’s deeply unfair,” Looser says. “And that speaks to a lot of people.”

    2. She used humor to brilliant effect. She also brought the funny, whether through Pride and Prejudice’s Mrs. Bennet’s humblebragging about her daughters or Persuasion’s Sir Walter Elliot, who reads about “his own history with an interest that never failed.” Looser says Austen was exceptional for “creat[ing] comic fiction of lasting genius, either on the level of the word, sentence, chapter, character or plot,” says Looser. “These characters resemble real people.”

    3. She understood love.Pride and Prejudice is the uber–romance novel,” says best-selling YA novelist Nicola Yoon (Everything, Everything), who wrote the introduction to the new Vintage Classic edition of the book. “You can see [Elizabeth and Darcy] working their way towards each other, [but] before they can get to each other, they have to get through themselves and their flaws and obstacles,” Yoon says. “We’re still feeling what Jane Austen wanted us to feel. It’s a bit magical.”

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  • Get Ready For Our Singapore Fan Zone 2025

    Get Ready For Our Singapore Fan Zone 2025

    The Atlassian Williams Racing Fan Zone World Tour is making its next stop in Singapore, giving fans the opportunity to hear from Thai F1 driver Alex Albon and the team ahead of the 2025 Singapore Grand Prix.

    Kicking off on Monday 29th September, the Atlassian Williams Racing Fan Zone gives fans truly unmatched access, bringing the excitement of racing to the cities they live in. A range of interactive experiences allow fans to get closer to the sport than ever, regardless of whether they have tickets to the race on Sunday.

    The Singapore Fan Zone also marks Alex’s honorary home race, with festivities continuing for an additional two days until Tuesday 7th October.

    Customise your Driver Card to begin!

    Your Fan Appreciation 2025 journey starts now…

    During the Fan Zone, fans will have the opportunity to:

    Hear Q&As from: Alex Albon, Lia Block, Jenson Button and James Vowles – stay tuned for full details, sign up to be the first to know.

    Show their speed at the Marina Bay Street Circuit on our state-of-the-art esports simulators, plus race against friends and competitors for special prizes

    Discover our partners and try their hand at driving Komatsu’s Haul Truck Simulator

    Test their reflexes just like our drivers on the batak reaction machines and Reaction Ring game

    Get up close with our FW47 show car

    Explore Williams’ decorated history in the Heritage Zone

    Get their hands on exclusive Atlassian Williams Racing merchandise

    Event Details

    Location: Central Atrium, L2, Marina Square, 6 Raffles Blvd, Singapore 039594

    Dates: Monday 29th September – Tuesday 7th October

    Opening Hours: 11am – 9pm daily

    Entry Information

    All fans wishing to attend the Fan Zone will be required to:

    Download and register an account on our official Atlassian Williams Racing app
    Create their customisable Driver Card

    Upon arrival, fans must present their Driver Card to a staff member for entry.

    With our app, fans can take part in the digital treasure hunt by tapping NFC tags around the Fan Zone to unlock badges – collect them all and win prizes.

    Get our Official App

    Get even closer to Atlassian Williams Racing…

    About the Tour

    The 2025 Atlassian Williams Racing Fan Zone World Tour is part of our commitment to bring unrivalled access to fans in the cities we race in.

    In 2024, over 200,000 fans visited a Fan Zone from London to Tokyo, making Formula 1 accessible to fans of all ages.

    The Fan Zones were also recognised by The Race Awards in 2024, taking the title of Best Live Experience.

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