Saba L, Cau R, Murgia A, Nicolaides AN, Wintermark M, Castillo M, Staub D, Kakkos SK, Yang Q, Paraskevas KI, et al. Carotid Plaque-RADS: a novel stroke risk classification system. JACC Cardiovasc Imaging. 2024;17(1):62–75.
PubMed
Google Scholar
Kopczak A, Schindler A, Bayer-Karpinska A, Koch ML, Sepp D, Zeller J, Strecker C, Hempel JM, Yuan C, Malik R, et al. Complicated carotid artery plaques as a cause of cryptogenic stroke. J Am Coll Cardiol. 2020;76(19):2212–22.
PubMed
Google Scholar
Saba L, Saam T, Jäger HR, Yuan C, Hatsukami TS, Saloner D, Wasserman BA, Bonati LH, Wintermark M. Imaging biomarkers of vulnerable carotid plaques for stroke risk prediction and their potential clinical implications. Lancet Neurol. 2019;18(6):559–72.
PubMed
Google Scholar
Johri AM, Herr JE, Li TY, Yau O, Nambi V. Novel ultrasound methods to investigate carotid artery plaque vulnerability. J Am Soc Echocardiogr Off Publ Am Soc Echocardiogr. 2017;30(2):139–48.
Google Scholar
Schindler A, Schinner R, Altaf N, Hosseini AA, Simpson RJ, Esposito-Bauer L, Singh N, Kwee RM, Kurosaki Y, Yamagata S, et al. Prediction of stroke risk by detection of hemorrhage in carotid plaques: meta-analysis of individual patient data. JACC Cardiovasc Imaging. 2020;13(2 Pt 1):395–406.
PubMed
Google Scholar
Kamel H, Navi BB, Merkler AE, Baradaran H, Díaz I, Parikh NS, Kasner SE, Gladstone DJ, Iadecola C, Gupta A. Reclassification of ischemic stroke etiological subtypes on the basis of high-risk nonstenosing carotid plaque. Stroke. 2020;51(2):504–10.
PubMed
Google Scholar
Murata K, Murata N, Chu B, Watase H, Hippe DS, Balu N, Sun J, Zhao X, Hatsukami TS, Yuan C. Characterization of carotid atherosclerotic plaques using 3-Dimensional MERGE magnetic resonance imaging and correlation with stroke risk factors. Stroke. 2020;51(2):475–80.
PubMed
Google Scholar
Ota H, Reeves MJ, Zhu DC, Majid A, Collar A, Yuan C, DeMarco JK. Sex differences in patients with asymptomatic carotid atherosclerotic plaque: in vivo 3.0-T magnetic resonance study. Stroke. 2010;41(8):1630–5.
PubMed
Google Scholar
Ma X, Wang Q, Hu X, Wang X, Zhao Y, Liu X, Li J, Du Y, Wang M, Qiu C, et al. Association of sdLDL-C with incident carotid plaques with stable and vulnerable morphology: a prospective cohort study. Stroke. 2024;55(3):576–85.
PubMed
Google Scholar
Baradaran H, Eisenmenger LB, Hinckley PJ, de Havenon AH, Stoddard GJ, Treiman LS, Treiman GS, Parker DL, Scott McNally, J. Optimal carotid plaque features on computed tomography angiography associated with ischemic stroke. J Am Heart Association. 2021;10(5):e019462.
Google Scholar
Ning C, Ouyang H, Xiao J, Wu D, Sun Z, Liu B, Shen D, Hong X, Lin C, Li J, et al. Development and validation of an explainable machine learning model for mortality prediction among patients with infected pancreatic necrosis. EClinicalMedicine. 2025;80:103074.
PubMed
PubMed Central
Google Scholar
Yoo SK, Fitzgerald CW, Cho BA, Fitzgerald BG, Han C, Koh ES, Pandey A, Sfreddo H, Crowley F, Korostin MR, et al. Prediction of checkpoint inhibitor immunotherapy efficacy for cancer using routine blood tests and clinical data. Nat Med. 2025;31(3):869–80.
PubMed
PubMed Central
Google Scholar
Aaseth E, Halvorsen S, Helseth R, Gravning JA. Remnant cholesterol, plasma triglycerides and risk of cardiovascular disease events in young adults: a prospective cohort study. Eur J Prev Cardiol 2025. https://doi.org/10.1093/eurjpc/zwaf104
Björkegren JLM, Lusis AJ. Atherosclerosis: recent developments. Cell. 2022;185(10):1630–45.
PubMed
PubMed Central
Google Scholar
Peng M, Wang L, Xia Y, Tao L, Liu Y, Huang F, Li S, Gong X, Liu X, Xu G. High dietary inflammatory index is associated with increased plaque vulnerability of carotid in patients with ischemic stroke. Stroke. 2020;51(10):2983–9.
PubMed
Google Scholar
Gong P, Liu Y, Gong Y, Chen G, Zhang X, Wang S, Zhou F, Duan R, Chen W, Huang T, et al. The association of neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, and lymphocyte to monocyte ratio with post-thrombolysis early neurological outcomes in patients with acute ischemic stroke. J Neuroinflamm. 2021;18(1):51.
Google Scholar
Jiang L, Cai X, Yao D, Jing J, Mei L, Yang Y, Li S, Jin A, Meng X, Li H, et al. Association of inflammatory markers with cerebral small vessel disease in community-based population. J Neuroinflamm. 2022;19(1):106.
Google Scholar
Huo RR, Liao Q, Zhai L, You XM, Zuo YL. Interacting and joint effects of triglyceride-glucose index (TyG) and body mass index on stroke risk and the mediating role of TyG in middle-aged and older Chinese adults: a nationwide prospective cohort study. Cardiovasc Diabetol. 2024;23(1):30.
PubMed
PubMed Central
Google Scholar
Lopez-Jaramillo P, Gomez-Arbelaez D, Martinez-Bello D, Abat MEM, Alhabib KF, Avezum Á, Barbarash O, Chifamba J, Diaz ML, Gulec S, et al. Association of the triglyceride glucose index as a measure of insulin resistance with mortality and cardiovascular disease in populations from five continents (PURE study): a prospective cohort study. Lancet Healthy Longev. 2023;4(1):e23–33.
PubMed
Google Scholar
Min Q, Wu Z, Yao J, Wang S, Duan L, Liu S, Zhang M, Luo Y, Ye D, Huang Y, et al. Association between atherogenic index of plasma control level and incident cardiovascular disease in middle-aged and elderly Chinese individuals with abnormal glucose metabolism. Cardiovasc Diabetol. 2024;23(1):54.
PubMed
PubMed Central
Google Scholar
Sardu C, Pieretti G, D’Onofrio N, Ciccarelli F, Paolisso P, Passavanti MB, Marfella R, Cioffi M, Mone P, Dalise AM, et al. Inflammatory cytokines and SIRT1 levels in subcutaneous abdominal fat: relationship with cardiac performance in overweight Pre-diabetics patients. Front Physiol. 2018;9:1030.
PubMed
PubMed Central
Google Scholar
Sardu C, Paolisso G, Marfella R. Inflammatory related cardiovascular diseases: from molecular mechanisms to therapeutic targets. Curr Pharm Design. 2020;26(22):2565–73.
Google Scholar
Dolz S, Górriz D, Tembl JI, Sánchez D, Fortea G, Parkhutik V, Lago A. Circulating MicroRNAs as novel biomarkers of stenosis progression in asymptomatic carotid stenosis. Stroke. 2017;48(1):10–6.
PubMed
Google Scholar
Sardu C, Modugno P, Castellano G, Scisciola L, Barbieri M, Petrella L, Fanelli M, Macchia G, Caradonna E, Massetti M et al. Atherosclerotic plaque fissuration and clinical outcomes in pre-diabetics vs. normoglycemics patients affected by asymptomatic significant carotid artery stenosis at 2 years of follow-up: role of MicroRNAs modulation: the ATIMIR study. Biomedicines. 2021;9(4):401.
PubMed
PubMed Central
Google Scholar
Jochmann SL, Sievering EMW, Ernst J, Ringlstetter R, Grosshennig A, Weissenborn K, Grosse GM. Sex-Specific risk factors of nonstenotic carotid plaque in embolic stroke of unknown source: a case-control study. Stroke. 2024;55(2):296–300.
PubMed
Google Scholar
Gasbarrino K, Di Iorio D, Daskalopoulou SS. Importance of sex and gender in ischaemic stroke and carotid atherosclerotic disease. Eur Heart J. 2022;43(6):460–73.
PubMed
Google Scholar
Song JW, Cao Q, Siegler JE, Thon JM, Woo JH, Cucchiara BL. Sex differences in carotid plaque composition in patients with embolic stroke of undetermined source. J Am Heart Association. 2021;10(9):e020143.
Google Scholar
Sukhavasi K, Mocci G, Ma L, Hodonsky CJ, Diez Benevante E, Muhl L, Liu J, Gustafsson S, Buyandelger B, Koplev S, et al. Single-cell RNA sequencing reveals sex differences in the subcellular composition and associated gene-regulatory network activity of human carotid plaques. Nat Cardiovasc Res. 2025;4(4):412–32.
PubMed
PubMed Central
Google Scholar
Rexrode KM, Madsen TE, Yu AYX, Carcel C, Lichtman JH, Miller EC. The impact of sex and gender on stroke. Circul Res. 2022;130(4):512–28.
Google Scholar
Chen Z, Ouyang H, Sun B, Ding J, Zhang Y, Li X. Utilizing explainable machine learning for progression-free survival prediction in high-grade serous ovarian cancer: insights from a prospective cohort study. Int J Surg (London England). 2025;111:3224
Google Scholar
van Dam-Nolen DHK, van Egmond NCM, Dilba K, Nies K, van der Kolk AG, Liem MI, Kooi ME, Hendrikse J, Nederkoorn PJ, Koudstaal PJ, et al. Sex differences in plaque composition and morphology among symptomatic patients with Mild-to-Moderate carotid artery stenosis. Stroke. 2022;53(2):370–8.
PubMed
PubMed Central
Google Scholar
Tyrrell DJ, Blin MG, Song J, Wood SC, Zhang M, Beard DA, Goldstein DR. Age-Associated mitochondrial dysfunction accelerates atherogenesis. Circul Res. 2020;126(3):298–314.
Google Scholar
Kim SY, Cheon J. Senescence-associated microvascular endothelial dysfunction: a focus on the blood-brain and blood-retinal barriers. Ageing Res Rev. 2024;100:102446.
PubMed
Google Scholar
Paneni F, Osto E, Costantino S, Mateescu B, Briand S, Coppolino G, Perna E, Mocharla P, Akhmedov A, Kubant R, et al. Deletion of the activated protein-1 transcription factor JunD induces oxidative stress and accelerates age-related endothelial dysfunction. Circulation. 2013;127(11):1229–40. e1221-1221.
PubMed
Google Scholar
Luyendyk JP, Schoenecker JG, Flick MJ. The multifaceted role of fibrinogen in tissue injury and inflammation. Blood. 2019;133(6):511–20.
PubMed
PubMed Central
Google Scholar
Lei J, Zhou Y, Zhao H, Chen Y, Yan G, Wu L, Xu Y, Zhang J, Zhang X, Wang J, et al. Dabigatran activates inflammation resolution by promoting fibrinogen-like protein 2 shedding and RvD5(n-3 DPA) production. Theranostics. 2021;11(9):4251–61.
PubMed
PubMed Central
Google Scholar
Hahn J, Temprano-Sagrera G, Hasbani NR, Ligthart S, Dehghan A, Wolberg AS, Smith NL, Sabater-Lleal M, Morrison AC, de Vries PS. Bivariate genome-wide association study of Circulating fibrinogen and C-reactive protein levels. J Thromb Haemostasis: JTH. 2024;22(12):3448–59.
Google Scholar
Ménégaut L, Laubriet A, Crespy V, Leleu D, Pilot T, Van Dongen K, de Barros JP, Gautier T, Petit JM, Thomas C, et al. Inflammation and oxidative stress markers in type 2 diabetes patients with advanced carotid atherosclerosis. Cardiovasc Diabetol. 2023;22(1):248.
PubMed
PubMed Central
Google Scholar
Harmon EY, Fronhofer V, Keller RS, Feustel PJ, Zhu X, Xu H, Avram D, Jones DM, Nagarajan S, Lennartz MR. Anti-inflammatory immune skewing is atheroprotective: Apoe–/–FcγRIIb–/– mice develop fibrous carotid plaques. J Am Heart Association. 2014;3(6):e001232.
Google Scholar
Mawhin MA, Tilly P, Zirka G, Charles AL, Slimani F, Vonesch JL, Michel JB, Bäck M, Norel X, Fabre JE. Neutrophils recruited by leukotriene B4 induce features of plaque destabilization during endotoxaemia. Cardiovascular Res. 2018;114(12):1656–66.
Google Scholar
Montecucco F, Di Marzo V, da Silva RF, Vuilleumier N, Capettini L, Lenglet S, Pagano S, Piscitelli F, Quintao S, Bertolotto M, et al. The activation of the cannabinoid receptor type 2 reduces neutrophilic protease-mediated vulnerability in atherosclerotic plaques. Eur Heart J. 2012;33(7):846–56.
PubMed
Google Scholar
Fernandez DM, Rahman AH, Fernandez NF, Chudnovskiy A, Amir ED, Amadori L, Khan NS, Wong CK, Shamailova R, Hill CA, et al. Single-cell immune landscape of human atherosclerotic plaques. Nat Med. 2019;25(10):1576–88.
PubMed
PubMed Central
Google Scholar
Ma T, Gao Q, Zhu F, Guo C, Wang Q, Gao F, Zhang L. Th17 cells and IL-17 are involved in the disruption of vulnerable plaques triggered by short-term combination stimulation in Apolipoprotein E-knockout mice. Cell Mol Immunol. 2013;10(4):338–48.
PubMed
PubMed Central
Google Scholar
Zhao S, Yu S, Chi C, Fan X, Tang J, Ji H, Teliewubai J, Zhang Y, Xu Y. Association between macro- and microvascular damage and the triglyceride glucose index in community-dwelling elderly individuals: the Northern Shanghai study. Cardiovasc Diabetol. 2019;18(1):95.
PubMed
PubMed Central
Google Scholar
Wendorff C, Wendorff H, Pelisek J, Tsantilas P, Zimmermann A, Zernecke A, Kuehnl A, Eckstein HH. Carotid plaque morphology is significantly associated with sex, age, and history of neurological symptoms. Stroke. 2015;46(11):3213–9.
PubMed
Google Scholar
Mosquera JV, Auguste G, Wong D, Turner AW, Hodonsky CJ, Alvarez-Yela AC, Song Y, Cheng Q, Lino Cardenas CL, Theofilatos K, et al. Integrative single-cell meta-analysis reveals disease-relevant vascular cell States and markers in human atherosclerosis. Cell Rep. 2023;42(11):113380.
PubMed
Google Scholar
Franzén O, Ermel R, Cohain A, Akers NK, Di Narzo A, Talukdar HA, Foroughi-Asl H, Giambartolomei C, Fullard JF, Sukhavasi K, et al. Cardiometabolic risk loci share downstream cis- and trans-gene regulation across tissues and diseases. Sci (New York NY). 2016;353(6301):827–30.
Google Scholar
Yi Y, Luo Q, Chen J, Chen Z, Aydemir HA, Chen P, Tang J, Luo F, Fang Z. Association between the uric acid-to-HDL-cholesterol ratio (UHR) and the risk of cardiovascular disease and dyslipidemia: a population-based study. Lipids Health Dis. 2025;24(1):143.
PubMed
PubMed Central
Google Scholar
Li W, Chen D, Tao Y, Lu Z, Wang D. Association between triglyceride-glucose index and carotid atherosclerosis detected by ultrasonography. Cardiovasc Diabetol. 2022;21(1):137.
PubMed
PubMed Central
Google Scholar
Li Z, He Y, Wang S, Li L, Yang R, Liu Y, Cheng Q, Yu L, Zheng Y, Zheng H, et al. Association between triglyceride glucose index and carotid artery plaque in different glucose metabolic States in patients with coronary heart disease: a RCSCD-TCM study in China. Cardiovasc Diabetol. 2022;21(1):38.
PubMed
PubMed Central
Google Scholar
Guo Y, Wang F, Ma S, Mao Z, Zhao S, Sui L, Jiao C, Lu R, Zhu X, Pan X. Relationship between atherogenic index of plasma and length of stay in critically ill patients with atherosclerotic cardiovascular disease: a retrospective cohort study and predictive modeling based on machine learning. Cardiovasc Diabetol. 2025;24(1):95.
PubMed
PubMed Central
Google Scholar
Wu XB, Huang LX, Huang ZR, Lu LM, Luo B, Cai WQ, Liu AM, Wang SW. The lymphocyte-to-monocyte ratio predicts intracranial atherosclerotic stenosis plaque instability. Front Immunol. 2022;13:915126.
PubMed
PubMed Central
Google Scholar
Qin P, Ho FK, Celis-Morales CA, Pell JP. Association between systemic inflammation biomarkers and incident cardiovascular disease in 423,701 individuals: evidence from the UK biobank cohort. Cardiovasc Diabetol. 2025;24(1):162.
PubMed
PubMed Central
Google Scholar
Sarlon-Bartoli G, Bennis Y, Lacroix R, Piercecchi-Marti MD, Bartoli MA, Arnaud L, Mancini J, Boudes A, Sarlon E, Thevenin B, et al. Plasmatic level of leukocyte-derived microparticles is associated with unstable plaque in asymptomatic patients with high-grade carotid stenosis. J Am Coll Cardiol. 2013;62(16):1436–41.
PubMed
Google Scholar
Silvestre-Roig C, de Winther MP, Weber C, Daemen MJ, Lutgens E, Soehnlein O. Atherosclerotic plaque destabilization: mechanisms, models, and therapeutic strategies. Circul Res. 2014;114(1):214–26.
Google Scholar
Yurdagul A Jr. Crosstalk between macrophages and vascular smooth muscle cells in atherosclerotic plaque stability. Arterioscler Thromb Vasc Biol. 2022;42(4):372–80.
PubMed
PubMed Central
Google Scholar
Mazhar F, Faucon AL, Fu EL, Szummer KE, Mathisen J, Gerward S, Reuter SB, Marx N, Mehran R, Carrero JJ. Systemic inflammation and health outcomes in patients receiving treatment for atherosclerotic cardiovascular disease. Eur Heart J. 2024;45(44):4719–30.
PubMed
PubMed Central
Google Scholar
Moran CA, Collins LF, Beydoun N, Mehta PK, Fatade Y, Isiadinso I, Lewis TT, Weber B, Goldstein J, Ofotokun I, et al. Cardiovascular implications of immune disorders in women. Circul Res. 2022;130(4):593–610.
Google Scholar
Dushay J, Rickers ES, Wang E, Gilman J, Zhang Y, Blankstein R, Gervino EV, Jerosch-Herold M, Veves A. Effects of age and sex on systemic inflammation and cardiometabolic function in individuals with type 2 diabetes. J Am Heart Association. 2025;14(3):e037863.
Google Scholar
Fryk E, Rodrigues Silva VR, Bauzá-Thorbrügge M, Schmelz M, Gan LM, Strindberg L, Jansson PA. Feasibility of high-dose Tadalafil and effects on insulin resistance in well-controlled patients with type 2 diabetes (MAKROTAD): a single-centre, double-blind, randomised, placebo-controlled, cross-over phase 2 trial. EClinicalMedicine. 2023;59:101985.
PubMed
PubMed Central
Google Scholar
Darvish S, Murray KO, Ludwig KR, Avalani KH, Craighead DH, Freeberg KA, Bevers S, Reisz JA, D’Alessandro A, Moreau KL, et al. Preservation of vascular endothelial function in late-onset postmenopausal women. Circul Res. 2025;136(5):455–69.
Google Scholar