TO APPRECIATE the dilemmas the Food and Drug Administration (FDA) faces when it reviews new drugs targeting rare diseases, consider the recent rollercoaster ride of Sarepta Therapeutics, a biotech firm. In 2023 the FDA granted accelerated approval for its gene therapy for Duchenne muscular dystrophy, a rare genetic disorder that typically causes death in early adulthood. Peter Marks, director of the FDA’s biologics centre at the time, approved the treatment despite reviewers’ concerns about limited clinical data. Some hailed that as proof the FDA could be nimble in cases where sufferers had few options. The treatment costs an eye-watering $3.2m per patient, so the drug’s approval delivered Sarepta a major payday. But in the past four months three patients on Sarepta’s treatments have died from acute liver failure. On July 18th the FDA asked the firm to suspend distribution. Within days its stock lost nearly half of its value (see chart 1).
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‘Use your other senses’: pioneering show for the blind hits Edinburgh | Edinburgh festival
In the intimacy of a blacked-out theatre, the smell of freshly made coffee, cheap perfume and stuffed peppers becomes more pronounced. The weight of each character’s footsteps become recognisable.
Welcome to the Blind Theater from Brazil, where every scent is a prop, and an actor’s breathing and tread are their character’s signatures.
Before their Edinburgh fringe show begins, the blind actor Edgar Jacques briefs the audience on what to expect when they enter the entirely darkened space. It is a fringe first and will be an unusual, perhaps unsettling experience, he warns the sighted.
Sitting in pitch dark will “reach your other senses, and use your other senses. You will listen to things, you will smell things and maybe things will touch you, like the wind or maybe the rain.”
Before audiences line up single file, one hand resting on the shoulder of the person in front, everyone is cautioned to switch off their mobile phones and smartwatches, and to avoid stretching their legs in the small auditorium, where production staff taped out light leaking under the theatre door.
Although well established in São Paulo, the Blind Theater (Teatro Cego) production of Another Sight is one of several shows designed for visually impaired audiences being staged by the venue group Zoo for the first time at this year’s festival.
Another theatre company, Extant, has teamed up with the charity Sight Scotland and artists’ collective Visually Impaired Creators Scotland to put on three “enhanced” performances, which include touch tours of the shows and live audio description over headphones.
One semi-autobiographical Extant production, I Dream in Colour, was written by a fully blind writer Jasmin Thein. It recounts the trauma of a blind woman forced to weigh up losing her remaining eye owing to a tumour or risking cancer.
Another Sight, played by blind and sighted actors, examines Brazil’s class system and the politics of disability. It explores the tensions between a wealthy woman, Grace, confronting a cancer diagnosis, when her maid, Maria, returns to work as Grace’s domestic while she completes her own treatment for cancer.
Anxious to work again despite being clearly fragile and diminished by her chemotherapy, her presence triggers a powerful reaction from her employer. Their respective husbands, including Jacques, act as peace-makers.
For Jacques, the darkness offers him an equality that conventional theatre productions do not. Unlike on a fully lit stage, he is no longer defined by his disability or his physical movements and posture which, as a blind person, can be different from the sighted.
“We open this universe for blind actors to play not just blind characters, but the good guy, the bad guy, the princess, the frog, everybody. So in the darkness, a blind person can be like anybody else,” he told the audience earlier this week.
For Ana Righi, a fully sighted actor who played Grace, that means she has to emphasise the sound of her feet and voice far more deliberately. Facial expressions, makeup and physical movement are irrelevant. Speaking through a translator, Righi said that changes “a lot of elements … especially using breathing to express emotions”.
Actors move through the audience, which sits close to the small stage in a semi-circle, adding a spatial dimension by working in different parts of the room. Grace has “a very stiff, secure step, whereas the maid has a very timid step, like a person who’s always afraid”.
Another Sight is part of a series showcasing theatre, dance and clowning from São Paulo supported by the state government, the Brazilian consulate in Edinburgh and the local arts association Associação Paulista dos Amigos da Arte.
Paulo Palado, the show’s director, said blind actors were normally expected to play only blind characters. The approach taken in Another Sight lifted that restriction. The company realised the power of that only during their first show 13 years ago; they now have seven plays in that format.
Sensory perceptions are essential, Palado said. Those can include fans to provide a breeze or, in some shows, rain. It can be a special experience for unsighted audiences, too, who normally have audio description telling them what is happening in conventional theatre.
In this show blind and sighted people “are all in exactly the same situation. We have the same information. In this case audio description is not necessary because that language is for all.”
Another Sight runs at Playground 2 at Zoo Playground from 1–24 August
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Rape accuser had lunch with Haider Ali week after their Manchester meeting
Right-handed batter Haider Ali speaks during an interview at Kent County Cricket Ground. — Screengrab via Facebook/@PakistanCricketBoard/File LONDON: A British-Pakistani woman who accused Pakistani batter Haider Ali of assault maintained contact with the player for nearly two weeks and met him at a Manchester restaurant on July 23, sources close to the police investigation have confirmed to Geo News.
According to the sources, the female, who is in her mid-20s, met the cricketer at a hotel in Manchester on July 23 for the first time, but reported the rape assault around two weeks later on August 4.
Between the two dates, she made a special trip to Ashford, in Kent, and met the right-handed batsman for lunch and a walkabout in the city on August 1.
Two witnesses who saw the female with Ali at a local restaurant in Ashford shared that they also saw Ali and the female walking towards the train station the same afternoon, without noticing any animosity.
It’s understood that the female travelled from Manchester to Ashford on her own, which takes around four hours on each side. She reported the rape allegations to the Manchester Police three days after the Ashford meeting and nearly two weeks after the Manchester encounter on July 23.
Trusted sources said the woman, whose identity is known but cannot be disclosed, remained in contact with Ali during the two weeks leading up to her police complaint.
Sources familiar with the investigation shared that phone data seized by the Manchester Police shows their contact with each other was normal, after both their meetings. Sources also shared that the female was a fan of Ali and got in touch with the cricket star through social media sites in 2023.
The 24-year-old cricketer remained in police custody for nearly 48 hours, where he provided a written statement to the police, strongly denying the allegation of rape and stressing his innocence. The police returned his phone when releasing him on bail on the evening of August 7, pending further inquiries.
The police release suspects on bail in circumstances when there is not enough evidence to bring charges.
Greater Manchester Police said on August 8 that Ali was arrested on the allegations of rape after the police received a report of rape on August 4 and arrested Ali the following day.
The police said: “It’s alleged that the incident occurred on Wednesday, 23 July, 2025, at a premises in Manchester. The man has since been bailed pending further enquiries. The victim is being supported by officers.”
Ali was arrested at the Spitfire County Cricket Ground, Kent, from the Players’ Canteen Office. He was taken to the Canterbury Police Station by the Kent Police officers. Sources said he was not handcuffed.
The Pakistan Cricket Board (PCB) said Ali has been provisionally suspended for the duration of the criminal investigation.
“The PCB fully respects the legal procedures and processes of the United Kingdom and acknowledges the importance of allowing the investigation to run its due course,” the PCB said in a statement.
“Accordingly, the PCB has decided to place Haider Ali under provisional suspension, effective immediately, pending the outcome of the ongoing investigation.
“Once the legal proceedings are concluded and all facts have been duly established, the PCB reserves the right to take appropriate action under its Code of Conduct, if necessary.”
Ali has represented Pakistan in 35 Twenty20 internationals since making his debut in 2020, as well as two one-day internationals.
Disclaimer: Under UK law, sexual assault survivors can report the crime at any time, with no time limits. Women have reported decades-old assaults and won justice. There are no reporting restrictions in this case. Geo News has shared only the facts so far. The victim’s view is not included, as police have advised against contacting her. Geo News is committed to fair, fact-based reporting that seeks the truth and supports justice without bias.
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Apple Debuts AI-Powered Support Assistant Chatbot in iPhone App
In a quiet but significant move, Apple Inc. has begun integrating artificial intelligence chatbots into its customer support ecosystem, signaling a broader push into AI-driven services amid growing competition from rivals like OpenAI and Google. The rollout, spotted in the Apple Support app for iPhone users, introduces an AI-powered “Support Assistant” that handles queries ranging from device troubleshooting to account issues, potentially reducing the need for human intervention. This development comes as Apple navigates delays in its more ambitious AI features, such as an enhanced Siri, while experimenting with generative AI in less visible areas.
The chatbot, currently in a limited preview for select users, appears under a new “Chat” tab in the app. It leverages natural language processing to provide responses, but Apple has included a disclaimer warning that the tool “may get things wrong,” urging patience from users. This cautious approach reflects broader industry concerns about AI accuracy, especially in high-stakes customer service scenarios where errors could erode trust.
The Evolution of AI in Customer Support
Industry observers note that Apple’s foray into AI chatbots aligns with a trend where tech giants are automating support to cut costs and improve efficiency. According to a report from TechRadar, the feature was secretly deployed while users await Siri’s full AI upgrade, highlighting Apple’s strategy of incremental AI integration. Sources indicate the chatbot is built on a stripped-down version of Apple’s in-house AI models, designed to compete with tools like ChatGPT without the computational overhead.
This isn’t Apple’s first brush with AI in support; the company has long used machine learning for diagnostics in its apps. However, the new chatbot represents a step toward conversational AI, capable of understanding context and escalating complex issues to human agents. Reports suggest it’s being tested in regions like the U.S. and Canada, with plans for wider rollout tied to iOS updates.
Challenges and Risks in AI Deployment
Despite the promise, experts warn of pitfalls. A piece in Gadgets360 details how the AI assistant is rolling out to some iPhone users, emphasizing its ChatGPT-like interface but with Apple’s privacy-focused twist—no data is stored externally. Yet, the disclaimer about potential inaccuracies underscores a key challenge: AI hallucinations, where bots provide plausible but incorrect information, could frustrate users accustomed to Apple’s polished experiences.
Comparisons to competitors reveal Apple’s measured pace. While Microsoft and Amazon have aggressively deployed AI in customer service, Apple’s version prioritizes integration with its ecosystem, such as linking to AppleCare services. Insights from TechCrunch suggest this chatbot is part of a larger “answer engine” project, aiming to deliver concise, reliable responses without the verbosity of broader AI models.
Implications for the Tech Industry
For industry insiders, this move raises questions about labor dynamics in customer service. As AI handles routine queries, human roles may shift toward oversight and complex problem-solving, potentially leading to workforce reallocations. A 9to5Mac analysis notes the limited test phase, indicating Apple is gathering feedback to refine the tool before a full launch, possibly coinciding with Apple Intelligence features in iOS 18.
Moreover, the integration hints at Apple’s broader AI ambitions. With reports from Engadget revealing an internal team named “Answers, Knowledge and Information” working on this, it positions Apple to challenge dominant players in enterprise AI. Privacy remains a cornerstone—unlike some rivals, Apple’s chatbot processes data on-device where possible, aligning with its brand ethos.
Future Prospects and Strategic Positioning
Looking ahead, success will depend on user adoption and iterative improvements. If the chatbot proves reliable, it could extend to other Apple services, like retail apps or even hardware diagnostics. However, as highlighted in The Times of India, recent updates to the Support app’s terms suggest an imminent wider release, complete with safeguards against misuse.
Ultimately, Apple’s AI chatbot initiative exemplifies a pragmatic blend of innovation and caution, setting the stage for how tech firms might redefine customer interactions in an AI era. As the company refines this tool, it could influence standards for accuracy, privacy, and seamlessness across the sector, potentially reshaping expectations for automated support worldwide.
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‘This is a major finding’
While you likely hear about carbon dioxide in a negative way, it can be turned into useful things. And although the process isn’t efficient, a team of researchers may have discovered a better way.
According to Tech Xplore, carbon dioxide can be turned into alcohols, ethylene, or carbon monoxide using a method called electrochemical CO2 reduction, using electricity — preferably from renewable sources. It “can be further refined into fuels or used in industrial processes, potentially turning a major pollutant into a feedstock.”
Unfortunately, the process creates potassium bicarbonate salts, which clog up the gas flow channels.
A team of researchers at Rice University has discovered that using acid-humidified CO2 instead of water is much more efficient.
Tech Xplore wrote: “In tests using a silver catalyst — a common benchmark for converting CO2 to carbon monoxide — the system operated stably for over 2,000 hours in a lab-scale device and more than 4,500 hours in a 100-square-centimeter, scaled-up electrolyzer.”
In comparison, water-humidified CO2 failed after 80 hours due to salt buildup.
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Co-first author and Rice chemical and biomolecular engineering graduate student Ahmad Elgazzar said: “This is a major finding for CO2 electrolysis.”
The study was published in Science.
Given that the planet has more carbon dioxide than nature can absorb, finding a way to turn the harmful gas into something useful is a great way to get rid of the excess gas. Carbon dioxide is one of the poisonous gases that are produced by dirty energy sources. These toxic gases contribute to the planet’s warming, which is causing extreme weather events that also threaten the world’s food crops.
One way to combat poisonous gases is for society to reduce its reliance on dirty energy sources so that less toxic gas is released into the atmosphere.
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In the meantime, projects like electrochemical CO2 reduction using acid bubbles are one way to help eliminate the toxic gas, and you can donate to climate causes that are doing this vital work.
Join our free newsletter for weekly updates on the latest innovations improving our lives and shaping our future, and don’t miss this cool list of easy ways to help yourself while helping the planet.
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Dealing With Stress? Maybe Your New Fitness Tracker Can’t Help – PCMag
- Dealing With Stress? Maybe Your New Fitness Tracker Can’t Help PCMag
- Smartwatches offer little insight into stress levels, researchers find The Guardian
- Is Wearable Tech Making Us Healthier—or Just More Neurotic? The Daily Beast
- New Study Finds Smartwatches Aren’t That Good at Measuring Stress Gizmodo
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Today’s the last day to get Battlefield 6 beta rewards y’all
Players can earn skins and other rewards that can be used in the full Battlefield 6 game by doing challenges.
The first open beta for Battlefield 6 has been a resounding success for the franchise, surpassing the all-time high set by Call of Duty for player counts on Steam at more than half a million participants.
If you’re one of the players who took part in the Battlefield 6 beta or haven’t played but are thinking whether it’s worth it, don’t forget that the open beta also grants exclusive rewards that can be carried over to the official release on Oct. 10.
Here is a list of Battlefield 6 beta rewards and how to get them for you completionists out there direct from EA. Note that you can only get the first set of these rewards on the first week of the beta as the second week will feature its own set of different rewards.
- Challenge 1: Reach Level 10. Reward: Lights Out Player Card
- Challenge 2: Reach Level 15. Reward: All Terrain Character Skin
- Challenge 3: Reach Level 20. Reward: Night Terror Weapon Charm
- Challenge 4 (Assault): Get 50 Close Quarter Kills within 10 meters. Reward: Striking Distance Weapon Package
- Challenge 5 (Support): Revive 100 teammates. Reward: Own the Night Weapon Sticker
- Challenge 6 (Engineer): Repair 3000 health to vehicles. Reward: After Dark Weapon Sticker
- Challenge (Recon): Spot 300 Enemies. Reward: Seeker Character Skin
Here are the three challenges in Weekend 2 of the Battlefield 6 beta and their rewards:
- Challenge 1: Capture 42 flags in Conquest, Domination or King of the Hill. Reward: War Machine Vehicle Skin
- Challenge 2: Get 200 kills or assists. Reward: Bat Company Dog Tag
- Challenge 3: Capture 10 sectors in Breakthrough or Rush. Reward: Dominion Weapon Package
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Mexico sets minimum export prices for fresh tomatoes – Reuters
- Mexico sets minimum export prices for fresh tomatoes Reuters
- Ag commissioner: West Virginia farmers markets will ‘be more competitive’ following 17% tomato tariff WV News
- Amid tomato tariffs, garden guru encourages people to grow their own produce Spectrum News
- ‘Food security is national security’: Alabama farmer seeing new buyers within days of Trump’s tomato tariff on Mexico — why he says former trade deal ‘never worked’ for US farmers moneywise.com
- Mexico Sets Tomato Export Prices to Ease US Trade Spat Yahoo Finance
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Meghan Markle fears over Prince Harry, King Charles reunion revealed
Meghan Markle concerned as Prince Harry seeks Royal forgiveness Meghan Markle is reportedly scared that she will be pushed aside if Prince Harry reconnects with royal family.
According to a royal expert, the Duchess of Sussex is deeply concerned about a possible reconciliation between the Duke and King Charles.
Speaking on The Sun’s YouTube channel, royal expert Kinsey Schofield said Meghan does not want to reconnect with the royals.
She claimed that Meghan fears they might push her aside and have more influence over Harry than she does.
“My understanding is that Meghan Markle has no desire to connect to the British Royal Family,” Schofield said.
She added, “Meghan’s concern is that they would push her out. That they would have more influence on Prince Harry than she does.
“I feel like this is a last resort for Prince Harry, who has kind of stumbled over the last few years.”
This comes after Harry shared his official diaries with the Buckingham and Kensington Palace to avoid clashes with the royal family following “peace talks” with Charles’ team in London.
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Štefan Jug, towering figure in handball refereeing, passes away
With profound sorrow, the global handball family bids farewell to Štefan Jug, a towering figure of Slovenian and international handball, who passed away at the age of 82. A pioneer, leader, and mentor, Jug devoted his life to the sport with unwavering commitment, leaving an enduring legacy that will continue to inspire generations.
An elite international referee across three decades, Jug rose to prominence early in his career. In 1971, he became the youngest referee in the former Yugoslavia. Together with his long-time partner, the late Herbert Jeglič, who also passed away in 2025, Jug formed one of the most distinguished refereeing pairs in handball history.
The duo officiated at 11 IHF World Championship editions and two editions of the Olympic Games, including Seoul 1988—where Jeglič and Jug became the first Slovenians to officiate an Olympic final—and Barcelona 1992. They also took charge of the 1990 IHF Men’s World Championship final in former Czechoslovakia.
The former referee’s impact was felt beyong the court. After his active refereeing career, he served as a referee delegate and supervisor at domestic and international levels, contributing his expertise for the worldwide education. He was a valued member of expert commissions in Slovenia and the former Yugoslavia, as well as a lecturer for both the International Handball Federation and the European Handball Federation. He continued to work tirelessly in the development of young referees, helping to forge new generations of Slovenian and international officials.
On behalf of the international handball community, Dr Hassan Moustafa, the IHF President, extends the deepest condolences to his family, friends, and all who knew and respected him.
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