Why demand for wearable health monitoring devices is accelerating in 2025
How the Herz P1 Smart Ring tracks heart rate, sleep patterns, stress levels, and activity metrics around the clock
The design elements that make Herz P1 comfortable for all-day, all-night wear
The role of real-time data insights in improving personal wellness decisions
Market trends showing how smart rings are reshaping the future of health technology
Which types of users benefit most from 24/7 wearable monitoring solutions
Balanced perspectives on the strengths and limitations of smart ring technology
Herz P1’s mission to make advanced health tracking accessible and easy to use
TL;DR SUMMARY
The Herz P1 Smart Ring is a next-generation wearable designed to deliver 24/7 health monitoring, including heart rate tracking, sleep analysis, stress measurement, and activity tracking — all in a sleek, comfortable ring. As consumer interest in personalized wellness technology grows in 2025, the Herz P1 stands out for its blend of precision sensors, minimalist design, and real-time data feedback. This article explores why demand for smart rings is surging, how Herz P1 works, who it’s designed for, and the broader trends shaping the wearable health market. With balanced insights into both the advantages and limitations of smart ring technology, readers will gain a clear understanding of how the Herz P1 Smart Ring fits into the future of health and wellness.
SECTION 1 — WHY INTEREST IN “SMART RINGS” IS SURGING IN 2025
The global wearable technology market is experiencing one of its most significant shifts yet in 2025 — and smart rings are at the center of this transformation. While smartwatches have long dominated the space, a growing number of consumers are seeking devices that deliver comprehensive health insights without the bulk or constant on-screen distractions. This demand has fueled a surge in interest for sleek, discreet wearables like the Herz P1 Smart Ring, which offers advanced tracking capabilities while maintaining a minimal footprint in daily life.
Several market forces are driving this trend. First, the wellness industry has expanded its focus from fitness alone to overall health optimization, placing greater value on continuous, passive monitoring of vital signs. The rise of preventative health is reshaping how consumers view their overall health management. Today’s wearables, including the Herz P1, play an integral part in this transformation, empowering individuals to track metrics like heart rate, sleep patterns, and stress levels in real time.
Second, more individuals are prioritizing stress management, sleep quality, and heart health as key components of long-term well-being — areas where smart rings excel due to their constant skin contact and high sensor accuracy. According to recent studies, stress-related illnesses and sleep disorders are on the rise globally, further driving the demand for accessible solutions like the Herz P1 Smart Ring.
Third, technological advancements have made it possible to pack precision sensors, Bluetooth connectivity, and long-lasting batteries into a compact, stylish form factor. As consumer awareness increases about the power of data-driven decisions, real-time data combined with long-term trend tracking helps users adjust their routines to achieve optimal health outcomes.
The growing intersection of fashion, comfort, and technology positions smart rings not just as gadgets but as integral tools for everyday health management. With the Herz P1, users gain access to advanced health insights without sacrificing style or comfort.
Learn more about the full features and specifications of the Herz P1 Smart Ring.
SECTION 2 — HOW THE HERZ P1 SMART RING DELIVERS 24/7 HEALTH MONITORING
The Herz P1 Smart Ring is engineered to provide continuous, around-the-clock health tracking without disrupting daily routines or sleep. Its design integrates advanced biometric sensors directly into a lightweight titanium alloy band, ensuring constant skin contact for optimal reading accuracy. Unlike bulkier devices, the ring format allows for consistent wear — even while sleeping, exercising, or performing everyday activities.
At the core of its functionality is a multi-sensor system capable of capturing key wellness metrics in real time. This includes heart rate monitoring, sleep cycle analysis, stress level measurement, and activity tracking, all of which are transmitted to a companion app for easy review. The app’s dashboard organizes data into intuitive charts and trends, making it simple for users to understand their health patterns and identify changes over time.
The sleep tracking feature is particularly notable. By monitoring resting heart rate, micro-movements, and body temperature, it can map out light, deep, and REM sleep stages, offering actionable insights into how rest quality impacts overall wellness. Sleep is often overlooked in wellness regimens, but its importance in recovery, mood regulation, and cognitive function is clear. The Herz P1 helps individuals understand the direct impact their sleep has on their health, including how external factors like stress and exercise influence sleep patterns.
The stress monitoring function also utilizes heart rate variability (HRV) to detect elevated tension levels, enabling users to take proactive steps toward relaxation and recovery. This level of monitoring, while valuable for anyone, can be especially beneficial for busy professionals or parents who face high daily stressors.
Battery efficiency is another advantage — the Herz P1 Smart Ring is designed for extended wear between charges, ensuring uninterrupted monitoring for days at a time. Combined with its durable, water-resistant construction, the device supports a seamless integration into users’ daily lives while maintaining accuracy and reliability in various environments.
SECTION 3 — KEY FEATURES THAT MAKE THE HERZ P1 STAND OUT IN THE SMART RING MARKET
In a rapidly expanding wearable technology landscape, the Herz P1 Smart Ring distinguishes itself through a combination of precision engineering, user-focused design, and comprehensive functionality. While many smart rings offer basic tracking, the Herz P1 integrates an advanced set of features that appeal to both wellness enthusiasts and everyday users seeking reliable health insights.
One of its defining attributes is the high-accuracy biometric sensor suite, which captures continuous heart rate, sleep stages, stress levels, and daily activity data. This level of detail is comparable to — and in some cases exceeds — what’s found in larger wrist-worn devices, but without the added bulk. The ring’s minimalist design also ensures it complements both casual and formal attire, making it practical for 24/7 wear.
The Herz P1’s companion mobile app enhances its usability by presenting clear, actionable information. Data visualizations allow users to easily interpret trends, while goal-setting tools help align daily habits with long-term health objectives. For those who value discretion, the device’s low-profile form factor ensures advanced tracking without drawing attention, a benefit for professionals and individuals in social settings.
Another key strength is its durability and comfort. Constructed from lightweight yet robust titanium alloy, the Herz P1 is resistant to scratches, moisture, and temperature fluctuations. The ergonomic inner band ensures a comfortable fit for long-term wear, even during intense workouts or overnight use. Battery life optimization means users can enjoy uninterrupted tracking for multiple days before needing to recharge.
By merging fashion, comfort, and science-backed performance, the Herz P1 Smart Ring positions itself as a versatile choice in the wearables market — bridging the gap between traditional health trackers and next-generation, discreet monitoring solutions.
SECTION 4 — INTEGRATION WITH OTHER DIGITAL HEALTH TOOLS
The Herz P1 Smart Ring does not just operate in isolation; it seamlessly integrates with a variety of health and wellness platforms to offer a more holistic view of your wellness journey. It can sync with fitness apps like Strava or Google Fit, allowing users to consolidate their health data across multiple platforms for easier management and analysis. This integration enables users to set personalized wellness goals, track progress over time, and gain a deeper understanding of how their lifestyle affects their overall health.
In addition, the Herz P1 is also designed to integrate with smart home devices such as sleep trackers, air purifiers, or temperature regulation systems, offering users a connected ecosystem for optimal wellness. Imagine your smart ring communicating with your home’s thermostat to adjust the room temperature based on the sleep data it collects, or sending alerts about elevated stress levels to help prompt mindfulness practices — all integrated into one unified health experience.
This interconnectedness makes the Herz P1 an essential part of any modern health monitoring routine, helping users make informed, data-driven decisions to support their long-term health goals.
SECTION 5 — WHO BENEFITS MOST FROM USING THE HERZ P1 SMART RING
The Herz P1 Smart Ring is designed to serve a diverse range of users, making it a versatile health monitoring solution for various lifestyles and wellness goals. Its discreet size and advanced capabilities appeal to those who value both functionality and aesthetics, while its ease of use ensures accessibility for individuals at different stages of their health journey.
Health-conscious professionals are a prime audience, as the ring enables them to monitor key wellness metrics without disrupting their busy schedules. With its subtle design, it can be worn in boardrooms, during travel, or in client-facing roles without attracting attention, while still providing continuous tracking in the background.
Athletes and fitness enthusiasts also stand to benefit from the Herz P1’s precision tracking. By analyzing heart rate variability, recovery patterns, and sleep quality, they can fine-tune training programs and improve recovery strategies, ultimately supporting better performance outcomes.
For individuals managing stress or seeking to improve sleep quality, the ring’s continuous monitoring provides valuable feedback. Real-time stress detection empowers users to take preventative action, while detailed sleep insights help identify habits or factors that may be affecting rest.
Older adults and those monitoring heart health can use the Herz P1 as a non-invasive, easy-to-wear tool to stay informed about their wellness status. Its intuitive app interface and long battery life make it a low-maintenance option for consistent use.
Overall, the Herz P1’s combination of accuracy, comfort, and all-day wearability ensures it can meet the needs of anyone seeking reliable, data-driven health insights without the inconvenience of larger, more obtrusive devices.
SECTION 6 — THE GROWING MARKET FOR WEARABLE HEALTH TECHNOLOGY IN 2025
The wearable health technology market has seen consistent growth over the past decade, and 2025 is shaping up to be a pivotal year for innovation, adoption, and consumer expectations. Advancements in sensor technology, data analytics, and miniaturization have opened the door for devices like the Herz P1 Smart Ring to provide comprehensive monitoring in a discreet, stylish form.
A major factor driving demand is the increased consumer focus on preventative health. Rather than waiting for medical issues to arise, individuals are seeking tools that can help them monitor their wellness daily, catch early warning signs, and make informed lifestyle adjustments. Wearables offer a convenient way to collect and review this data without requiring invasive procedures or frequent clinic visits.
The rise of remote work and hybrid lifestyles has also played a role. With more time spent at home, users are taking a greater interest in self-tracking and optimizing health habits. Devices that deliver actionable insights — such as sleep cycle reports, heart rate trends, and stress level analysis — are in high demand.
Additionally, the integration of AI and cloud-based analytics is transforming the wearable experience. Smart rings like the Herz P1 can sync with secure apps to provide personalized recommendations based on long-term data patterns, allowing for a level of customization that was not possible just a few years ago.
Finally, the fashion-forward approach to wearable design is attracting a broader demographic. The Herz P1’s minimalistic, premium look means it appeals not only to tech enthusiasts but also to style-conscious users who previously avoided bulkier health trackers.
With these trends converging, the wearable tech sector is set for rapid expansion, and smart rings are emerging as one of the most promising categories within it.
Discover how the Herz P1 Smart Ring supports health and wellness monitoring.
Address: WuzuTech LLC 839 E Market St Ste 106 #165 Akron, OH 44305 United States
Disclaimer: The statements in this release are for informational purposes only and are not intended to diagnose, treat, cure, or prevent any disease or health condition. The information provided about the Herz P1 Smart Ring is based on publicly available sources, manufacturer claims, and product descriptions at the time of publication. Individual results from using the product may vary.
This release does not constitute medical advice, and readers should consult a qualified healthcare professional before starting or changing any health-related regimen, including the use of wearable health devices. The Herz P1 Smart Ring is designed as a consumer wellness product and should not replace professional medical equipment or services.
The publisher of this release has no liability for any direct, indirect, or consequential damages arising from the use or misuse of the product. All product names, logos, and brands are the property of their respective owners.
More should be done to raise awareness and promote use of the Medicines and Healthcare products Regulatory Agency (MHRA) Yellow Card scheme, according to a report from Healthcare Improvement Scotland (HIS).
The report, published in June 2025, found that that just 10% of people who experienced medication side effects reported them through the Yellow Card scheme.
As part of the report, HIS surveyed Citizens’ Panel members on their public views concerning medicine safety, long-term conditions and preconception health and care.
Of the 563 responses received by post, email or over the phone, more than half of respondents (57%) said they had experienced a side effect or unintended effect from a medicine, the report found.
In addition, more than three-quarters of respondents (84%) had spoken to a doctor, nurse or pharmacist about medication side effects, while almost one-third of respondents (29%) had spoken to family and friends.
It is possible that low use of the scheme could be because people viewed their side effects as not significant enough to report; however, there could also be an opportunity to increase awareness of the scheme, the report said.
In the report, HIS recommends taking “action to promote and support public awareness of the Yellow Card scheme to improve underreporting of medicines’ side effects” and to “improve how NHS Scotland draws learning from the data that are collected and analysed through the Yellow Card scheme”.
On 7 August 2025, Laura Fulton, chief pharmacist of HIS, said the scheme is “vital to improve our understanding of medicines and safeguard patients”.
“I would encourage patients, members of the public and healthcare professionals to proactively utilise the Yellow Card scheme and report any concern as soon as they can,” she added.
Laura Wilson, director for Scotland at the Royal Pharmaceutical Society, commented: “It is extremely important that the public are aware of the ways they can report side or unintended effects from medicines. This helps to raise awareness of the potential effects of medicines and improves medicines safety.
“The Yellow Card scheme is a fantastic initiative, which makes this process accessible and straightforward. I would encourage everyone to make use of it.
“Yellow Card representatives will be exhibiting at our RPS Scottish conference later this month, and we look forward to engaging with them and learning more about their important work.”
In a letter published in The Pharmaceutical Journal in June 2025, pharmacists Rajesh Jethwa and Nathaniel Addo said that in a small survey of 25 healthcare professionals in East London, a clear majority (84% (n=21) were aware of the Yellow Card scheme.
However, 76% of respondents (n=19) had never reported a side effects through it, which suggests underutilisation of the scheme.
Baggy pants-wearing rapper MC Hammer is being sued in a US court for allegedly failing to pay off a car loan by JPMorgan Chase, which has claimed that he has stopped making payments on a luxury Land Rover.
The suit against Hammer – whose real name is Stanley Burrell — was filed in a California court last week. It names MC Hammer and U Can’t Touch This LLC as defendants in the case, claiming the bank loaned them $114,000 to buy the vehicle in 2023.
But after allegedly missing a number of monthly payments, the rapper and his company still owe more than $76,000.
Hammer broke onto the rap scene in the 1980s, but became a global figure with 1990 megahit “U Can’t Touch This.” The rapper’s signature “Hammer Pants,” coupled with his rapidly moving elastic legs, made for a dance move that was copied all over the world.
Despite a tie-up Mattel figurine and the “Hammerman” cartoon, his stardom waned and by the mid-1990s, Hammer was going through bankruptcy.
Australia’s foreign affairs minister, Penny Wong, has joined fresh international condemnation of Israel’s plans to control more of Gaza in a new ground offensive, warning it risks breaching international law and putting the lives of hostages and civilians in renewed danger.
Wong joined the foreign ministers of Germany, Italy, New Zealand and the UK in a joint statement on Saturday, saying the plans by Israel’s prime minister, Benjamin Netanyahu, to control Gaza City will make an already perilous situation worse.
They said the “worst-case scenario” of mass famine was already unfolding in Gaza.
“The plans that the government of Israel has announced risk violating international humanitarian law. Any attempts at annexation or of settlement extension violate international law,” the statement said.
“It will aggravate the catastrophic humanitarian situation, endanger the lives of the hostages, and further risk the mass displacement of civilians.”
Netanyahu’s war cabinet on Friday went against the advice of Israel’s military leaders to agree on a further escalation in the 22-month war, planning a full takeover of Gaza’s largest city that is likely to result in mass displacement of an estimated 1 million Palestinians.
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The moves sparked international outrage.
Germany’s government moved quickly to suspend the delivery of weapons that could be used in the fighting. The plan has not been opposed by the US president, Donald Trump, Netanyahu’s strongest backer internationally.
Wong and her counterparts said terror group Hamas and the Israeli government should work with the international community to end the war through an immediate and permanent ceasefire.
Such a development must enable the provision of a massive, immediate and unimpeded humanitarian assistance, “as the worst-case scenario of a famine is unfolding in Gaza”.
“Hamas must release all hostages without further delay or precondition and must ensure they are humanely treated and not subject to cruelty and humiliation,” the statement said.
“We call on the government of Israel to urgently find solutions to amend its recent registration system of international humanitarian organisations, to ensure these vital actors of humanitarian aid can continue their essential work again in line with humanitarian principles to reach the civilians in need in Gaza.
“Their exclusion would be an egregious signal.”
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Hamas said in a statement that Netanyahu’s plans meant he had abandoned the surviving hostages seized by the group in its surprise attack on Israel in October 2023, which triggered the war. The statement accused the Israeli prime minister of “sacrificing them to serve his personal interests and extremist ideological agenda”.
Countries including Australia have called for a political solution in Gaza that does not involve any of the Hamas leadership. Israel said it wanted to eventually hand control of Gaza over to a group of friendly Arab forces who are opposed to Hamas.
Netanyahu has released a list of five key objectives for the escalated fighting: disarming Hamas, returning all hostages, demilitarising the entire Gaza Strip, taking security control of the territory, and establishing “an alternative civil administration that is neither Hamas nor the Palestinian Authority”.
Wong said on Friday Israel should not go down its planned path, and permanent forced displacement would be a violation of international law.
But frequent statements from world leaders appear not to be deterring Israel.
Netanyahu’s office told international media the Israeli army would prepare to “take control of Gaza City while distributing humanitarian assistance to the civilian population outside combat zones”.
The prime minister, Anthony Albanese, was expected to discuss the war during a meeting with his New Zealand counterpart, Christopher Luxon, in Queenstown on Saturday.
Actor-host Sanam Jung often talks about the challenges of her personal life.
Last year, she shared her experience of living abroad after marriage and the homesickness that comes with it. Fast forward to this year, Sanam made an appearance in TV show this week and discussed what motherhood is like while her husband has to leave home for work.
Sanam got married to Abdul Qassam Jafri in 2016. The two migrated to Houston, Texas in 2023 and Sanam talked about her ‘real rukhsati’ in an appearance on Shan e Suhoorc in 2024.
She shared that her and Jafri, who is a pilot, had initially agreed to maintain a long-distance relationship when he relocated to the US for his career. However, once Sanam’s green card came through, she made the decision to move to Texas with their daughter so they could all live under the same roof.
The actor gave birth to a baby girl Alaya in 2016 and announced it in a Facebook post. In 2024, Sanam announced the birth of their second daughter Aliza.
Whilst the family is happy to be together, Sanam still struggles to manage household chores alone. “Qassam is not home for 15 days every month due to work. When he comes back, he makes sure to sort all the groceries. He does all the major tasks which I might not be able to do as I take care of two kids. I can manage the rest on my own.”
The Jago Pakistan Jago host misses work but is unable to commit due to other responsibilities. “I can’t do an in-person job because of my kids.” she said. “I try to do Instagram endorsements and shout outs for brands. Even these things I try to do when my husband is home because I can’t leave my kids alone. It really scares me.”
She admitted her decision to leave behind work to focus on her kids has its downsides. “As someone who has always been very career-oriented, I do miss working,” she said.
In previous interviews, Sanam has also talked about the lack of household help abroad. “I took life for granted in Pakistan,” said the actor in Ramazan transmission Shan e Suhoor in 2023. “You don’t realise it, but when you move away, even if you run out of tomatoes, there is no one you can call on to run and get it for you. And if you spill something, there’s no one there to clean up after you. You have to do it all yourself.”
Despite not having the ideal situation, Sanam remains grateful. “Although I’m not working at the moment, I’m doing an even more important job which is to give time to my kids.”
Eddie Jen, a drag queen from San Francisco, wants to show that “America still fights for kindness”, while Abby Govindan, a US stand-up comic of Indian heritage, aims to convince audiences Texas is not what they think.
The performers are among those who make the number of US acts at this year’s Edinburgh Fringe the highest in at least a decade.
The Edinburgh International Festival, held every August, was established in the aftermath of World War II with the goal of using culture to heal divisions.
It immediately spawned an unofficial Fringe that became bigger than the original festival, attracting thousands of more maverick performers in venues across the city.
This year’s Fringe includes productions from Armenia to Zimbabwe, organisers say. The percentage of US acts is 12.1%, compared with 11.1% last year and 6.1% in 2014. No earlier data is available.
British acts have decreased to 69.8% of the total, from 71.2% in 2024, and 81.5% in 2014. Performers have said high costs, especially for accommodation, are a deterrent.
For US artists, that can matter less. Their numbers had already risen as producers chose Edinburgh to test the appeal of musicals as a cheaper alternative to Broadway.
US President Donald Trump, who changed laws on diversity after he returned to office in January, making many artists anxious about freedom of expression, is a factor.
Govindan said she would have brought her show “How to Embarrass Your Immigrant Parents” to Edinburgh “regardless of politics”.
Her aims include doing justice to Texas, which she says is “commonly misrepresented as white and racist”. “Houston, my hometown, is the most diverse city in the country,” she said.
Jen is also keen to get beyond stereotypes with “Seeking a Pen Pal for the End of the World” that tells the story of an immigrant drag queen exchanging letters with his high school English teacher – a retired, white, Republican woman from Bountiful, Utah.
“When Trump was re-elected in November, I wanted to let the world know that America still fights for kindness,” Jen said.
The number of Canadian acts at the Fringe has hovered around 1% for the last decade. Connor Malbeuf, who has lived in the United States for eight years, says the Fringe is “a safe space” for his show “Sorry: A Canadian’s Apology for America”.
“There’s no better neutral ground to comment on the absurdity, political landscape, and poke the bear without the bear threatening the possibility of deportation,” he said.
For Govindan, whose comedy is established in the United States, Edinburgh amounts to healthy risk-taking. “Being here is really pushing me out of my comfort zone in a way that is undoubtedly going to make me a better performer and comedian,” she said.
To our knowledge, this was the first study to investigate the nephrotoxicity and mortality difference between CS and CMS. The incidence rates of any-stage and stage 3 AKI were significantly lower in the CS cohort than in the CMS cohort. After AKI occurred, 13.64% of patients reduced the dose of polymyxins. 40.91% of patients discontinued polymyxins after developing AKI. 18.18% and 50% of patients demonstrated complete and non-recovery of renal function, respectively.
Past studies have shown that PMB is more toxic to the kidneys than CS. However, the two groups had similar mortality rates [5, 10]. Nevertheless, two retrospective studies found no significant difference between PMB- and CMS-induced AKI [5, 10, 15, 16]. and mortality was similar in patients treated with either agent [6, 9, 17]. To my knowledge, no real-world study has yet compared the nephrotoxicity of CS and CMS. In our studies, the CMS group had a higher incidence of AKI than the CS group, but a lower mortality rate. CMS therapy, along with a lower estimated glomerular filtration rate, was an independent risk factor for AKI. However, AKI occurrence is not a risk factor affecting mortality rate increase by multiple Cox regression analysis.
In the ICU-subgroup, CMS therapy, a lower baseline eGFR and concomitant treatment with ACEI were strongly associated with AKI. However, CMS administration and the combination of hypertension were significantly correlated with the AKI occurrence in the non-ICU subgroup. Multivariate analyses of CMS subgroup revealed that a lower eGFR and concomitant treatment with ACEI were independent risk factors for AKI. Several past clinical studies have associated CMS-induced nephrotoxicity with old age [18, 19], history of chronic kidney disease [19], Charlson score [18], baseline creatinine level [18] and concomitant treatment with vasopressor [19]. In the CS subgroup, multivariate analyses revealed that a lower baseline eGFR was an independent risk factor for AKI. However, CS-induced AKI was associated with advanced age [8, 20,21,22], high serum bilirubin [8], high APACHE II score [22], septic shock [23], diabetes mellitus [22], heart failure [22], higher baseline Scr level [20, 24, 25], low serum albumin [21], blood trough concentration [20], concomitant treatment with other nephrotoxic drugs [8, 21], vasopressors [25, 26], diuretics [25] and inotropes usage [22].
The incidence of polymyxin-induced nephrotoxicity varied among previous studies. This variability is due to heterogeneous patient populations, different definitions of nephrotoxicity, ranges of doses used, differences in the severity of illness, and the presence of potential confounders such as the concomitant use of other nephrotoxic agents [13]. Most reported nephrotoxicity was mild, and renal function gradually recovered after discontinuation of polymyxins administration [9, 27]. CMS is mainly eliminated by renal excretion, and the urinary excretion involves renal tubular secretion [28]. Colistin and polymyxin B have similar chemical structures and mechanisms of action, exert their therapeutic effect directly and are mainly eliminated through non-renal pathways. Colistin binds to megalin on the apical membrane of proximal tubular cells, triggering its reabsorption into these cells. Intracellular accumulation of colistin causes mitochondrial damage, death receptors activation, and cell apoptosis. Additionally, colistin enhances the permeability of the tubular epithelial cell membrane, leading to the influx of cations, anions, and water, which results in cellular swelling and lysis [29, 30]. Polymyxins are well known to be nephrotoxic to renal tubular cells. It is suggested that the differences in the pharmacokinetics and renal handling mechanisms of polymyxins may lead to higher colistin toxicity than PMB in humans [9]. Published theories have shown that the use of loading doses and the duration of treatment can lead to acute renal injury due to the cumulative effect of the dose [7, 8, 18, 31,32,33]. This has also been associated with higher plasma drug concentrations in some studies [34, 35]. Furthermore, a total dose of colistin > 5 g was an independent predictor of progression to chronic kidney disease [36].
In our study, the overall 30-day all-cause mortality rate was 23.37%, which is lower than in most previous reports on polymyxin drug therapy [5, 6, 9]. Moreover, the 30-day mortality rate was significantly higher in the CS cohorts than in the CMS cohorts regardless of propensity matching. The CS group exhibited a higher proportion of hematological system comorbidities, with more severe infection severity. In vitro studies have shown that even at the maximum tolerated systemic dose, PMB cannot achieve effective bactericidal activity. Given the structural similarity between CS and PMB, and that fAUC/MIC is the PK/PD index most closely related to efficacy, it is speculated that CS cannot achieve good bactericidal effects [37]. A systematic review showed that the blood drug concentration in the CS group is lower than that in the CMS group, and the peak time is later than that in the CMS group [38], which is one reasons for the higher mortality rate in the CS group.
In our study, multivariate analyses revealed that CS administration, ICU admission, and a polymyxin loading dose were independent risk factors for 30-day mortality. Unlike previous reports, mortality was associated with polymyxins-induced AKI [5, 8, 18, 19, 22, 24, 25], age [18], septic shock [8, 9], combination with lymphoma malignancy [8], SOFA score [39], extracorporeal membrane oxygenation treatment [39], hematologic malignancy [8], hypoproteinemia [8], mechanical ventilation [9], presence of a central venous catheter [9], higher baseline creatinine levels [18] and Charlson comorbidity index [9, 18, 19], concomitant use of vasopressors [19]. This may be related to the different patients enrolled and the types of polymyxins used.
However, our study had several limitations. Firstly, it was a retrospective study conducted in a single center with a limited sample size, and it included patients from a tertiary hospital. Despite employing propensity matching, there may still be an undisclosed quantity of residual unmeasured confounding and bias present in this observational study. Secondly, drug concentrations of colistin sulfate were not monitored during treatment and the correlation between nephrotoxicity and blood drug concentrations was not investigated. Thirdly, the majority of patients were treated with colistin sulfate alongside other drugs due to polymyxin’s heterogeneous resistance, meaning colistin sulfate may not be solely responsible for the ultimate effectiveness. Furthermore, considering the efficacy, safety, and cost-effectiveness of drug use, clinicians may not fully comply with international guidelines when selecting colistin dosing regimens, particularly with regard to loading doses and dosing intervals. This has also caused research bias. This could explain why the results of this study differ from those of previous studies. Therefore, future multicenter, randomized, controlled, prospective trials are needed to better assess the efficacy and safety of colistin sulfate.
OLED displays demand materials that can emit light with extreme efficiency, while deep-tissue medical imaging relies on compounds that absorb light in ways that minimise damage to living cells. These two worlds have long required separate solutions, until now.
Researchers at Kyushu University have developed a single organic molecule that can excel in both roles, potentially transforming consumer electronics and biomedical diagnostics alike.
The study showcases a breakthrough material that delivers efficient light emission for next-generation screens and strong light absorption for high-precision imaging deep inside the body.
The discovery could pave the way for devices that bridge entertainment and healthcare, using one molecule to power brighter displays and enable safer, sharper diagnostics.
Merging two elusive properties
OLEDs dominate modern displays, from smartphones to large televisions. Improving their efficiency often involves thermally activated delayed fluorescence (TADF).
This process converts normally wasted triplet-state energy into light-emitting singlet states using ambient heat. Materials with strong TADF can make displays brighter and more energy-efficient.
In medicine, deep-tissue imaging demands materials that work with low-energy, near-infrared light to reduce scattering and damage. Two-photon absorption (2PA) achieves this by allowing a molecule to absorb two lower-energy photons at once.
The technique excites only tissue at the laser’s focal point, enabling sharper, safer imaging.
Combining strong TADF and high 2PA in one molecule has long been a challenge. TADF works best in twisted molecular structures with separated electron orbitals. 2PA typically requires planar structures with high orbital overlap.
These demands often conflict, making dual-function molecules rare.
To solve this, the Kyushu-led team designed a molecule called CzTRZCN. It combines an electron-rich carbazole unit with an electron-deficient triazine core.
Cyano groups fine-tune the orbital arrangement by pulling electrons toward them.
This architecture lets the molecule act as a “switch.” During absorption, CzTRZCN maintains enough orbital overlap for efficient 2PA. Once excited, it changes structure to separate orbitals, enabling TADF.
This image depicts the structure of the proposed organic molecule, alongside the energy level diagrams of two-photon absorption (left side) and thermally activated delayed fluorescence (right side). Credit – Youhei Chitose/Kyushu University
The team validated this dual behaviour with theoretical calculations and experiments. In an OLED device, CzTRZCN reached an external quantum efficiency of 13.5%, a record for triazine-based TADF materials.
It also showed a high 2PA cross-section and strong brightness, making it promising for medical imaging.
Lead researcher Youhei Chitose said the molecule’s metal-free, low-toxicity nature makes it highly biocompatible, ideal for medical probes.
Time-resolved fluorescence microscopy could particularly benefit from the material’s performance.
Toward broader applications
The study outlines a strategy for creating molecules with different orbital arrangements for light absorption and emission. This approach could inspire new multifunctional materials beyond medical and display uses.
Chitose said the team plans to expand the design to cover more emission wavelengths and to collaborate with biomedical and device engineers. Possible applications include in vivo imaging, wearable sensors, and next-generation OLED displays.
By bridging photoelectronics and bioimaging, the work opens doors for devices that seamlessly cross between consumer electronics and healthcare.
If scaled, CzTRZCN could help create brighter, more efficient screens and more precise, less invasive imaging tools in medicine.
The study is published in the journal Advanced Materials.
August 8, 2025 – China – The story-driven RPG, Heaven Burns Red, has just announced that the Summer Campaign has now officially launched. During the Summer Campaign, players can log in to the game and complete missions to earn up to 10,000 Quartz and 3 SS Memorias for free. Meanwhile, the game will launch limited recruitments, with a total of 6 new SS Memorias to be introduced. At the same time, Main Scenario Chapter 5: Part 1 and brand-new story events will be made available. The Summer Campaign will be divided into two phases, from August 8th to August 21st and from August 22nd to September 4th respectively. The limited-time story events will end at 23:59 on September 4th (UTC -7).
Download Heaven Burns Red on PC from the official website.
Summer Campaign Rewards Announcement
During the Summer Campaign, players who have cleared Chapter 1 will receive a Base Outfit Recruitment Ticket, allowing them to draw 1 random outfit from a pool of 48 base outfits. Additionally, players who log in for any 10 days during the event period can claim an SS-Guaranteed 10-Roll Recruitment Ticket.
Throughout the campaign, extra daily login rewards will be available:
August 8th, 0:00 – September 4th, 23:59 (UTC-7): Log in daily to claim 1 free recruitment ticket per day, with a maximum of 20 free pulls!
August 22nd, 0:00 – September 4th, 23:59 (UTC-7): Log in daily to receive free 10-roll recruitment tickets. Accumulate up to 120 total pulls, and earn an exclusive SS-Guaranteed Ticket upon collecting all rewards.
Moreover, every weekend during the Summer Campaign, players will receive Life Stones and other in-game items via Gift Box. Complete weekly missions during the event to earn more bonuses.
Limited Recruitments
From August 8th to August 21st, two brand-new Featured Platinum Recruitments will be launched. Through them, players can recruit SS [Higher Than The Sun] Mari Satsukiand SS [Sunflower] Adelheid Kanzaki, as well as SS [Anticipant Ruby] Yuki Izumi and SS [Summer Daydream] Bon Ivar Yamawaki respectively.
From August 22nd to September 4th, a brand-new limited recruitment will be launched. During this period, players can obtain limited new SS Memorias: SS [Neverending Summer] Megumi Aikawa and SS [Summertide Shark the Ripper] Karen Asakura.
New Storyline Goes Live
Main Scenario Chapter 5: Part 1 – The Workings of the Soul and a Starcrossing Journey has launched. To celebrate the release of this chapter, all players will receive 3,000 Quartz via Gift Box as part of the Summer Campaign upon logging in.
Additionally, from August 8th, 00:00 to August 21st, 23:59 (UTC-7), the game will introduce a new story event: Silhouette of Summer Light Square. Adelheid Kanzaki and Mari Satsuki, as part of the PR department’s project, end up doing a gravure photoshoot. While carrying out their shoot, they also take on the mission of eliminating Cancers with the rest of Squad 31-C. Deep in the forest, they discover a hidden ninja mansion.
August 22nd, 00:00 – September 4th, 23:59 (UTC-7): The story event Rule the Swimsuit to Rule Summer: In Narashino –Supported by Higher Self– will be released. The members of Squad 31-A, clad in swimsuits, find themselves transported back to Narashino, four years in the past. Eager to make the most of their rare consecutive days off, the group throw themselves into fishing and scrap collecting. But among the newly arrived residents, they spot Rumi…
Watch the Event Story Trailer – Silhouette of Summer Light Square
Follow Heaven Burns Red EN
To learn more about Heaven Burns Red EN and stay tuned for upcoming news, please follow the game’s social media platforms:
Heaven Burns Red EN Official Homepage
Official X Account
Official Facebook Page
Official YouTube Channel
About WFS, Inc.
WFS, Inc. operates the game brand “WRIGHT FLYER STUDIOS,” a game development company that specializes in creating RPGs offering emotionally resonant narrative experiences. Under the vision of “Bringing The Amazing, To You.”, the company aims to create innovative gaming experiences and develop the finest games that many can enjoy.
About VISUAL ARTS/Key
VISUAL ARTS is a Japanese publishing company which specializes in producing animations and games from original works through collaborations with various companies. Creating content that is distributed worldwide and loved by people is the mission of VISUAL ARTS.
Key is a Japanese visual novel studio under the publisher VISUAL ARTS, known for making dramatic and plot-oriented titles such as Kanon, CLANNAD, Little Busters!, Summer Pockets, and more.
About Yostar Games
Founded in 2014, Yostar Games specializes in game development, global distribution, investment, and video game IP management. Situated in Tokyo and Shanghai, Yostar Games has rapidly become the top publisher and developer of the anime genre games in China and is striving to become a global leader in the gaming industry.
