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Engine issue on Northrop spacecraft delays NASA ISS cargo delivery – Reuters
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HPV inoculation drive faces early setback
RAWALPINDI:The cervical cancer vaccination campaign for girls aged nine to 14 suffered a serious setback on its very first day, as 4,824 parents in Rawalpindi district refused to allow their daughters to be immunised.
The drive, launched jointly by the United Nations International Children’s Emergency Fund (UNICEF) and the District Health Authority (DHA) without a large-scale public awareness effort, began on September 15 and is scheduled to run until September 27, with a target of vaccinating 387,334 girls.
According to figures released by the Health Department on the opening day, 24,179 girls received the HPV vaccine. Rawalpindi City recorded the highest uptake, with 5,370 inoculations, while parental refusal accounted for 4,824 cases. The twelve-day initiative seeks to immunise nearly 400,000 girls across the district.
Health officials have stressed that the HPV vaccine is both safe and effective, urging parents to ensure their daughters are protected, describing it as a proven safeguard against cervical cancer. They noted that the national immunisation programme already covers 12 life-threatening childhood diseases, with cervical cancer now added to shield women from one of the deadliest threats to their health. The jab is administered as a one-time dose for girls aged nine to 14.
The campaign, however, ran into early resistance largely due to the absence of a comprehensive awareness drive before its official launch on September 15.
Speaking to the media, Dr Ihsan Ghani, the DHA’s Chief Executive, maintained that awareness efforts had in fact been undertaken, though vaccination was made conditional upon parental consent. He observed that public response had been lukewarm, perhaps because the vaccine is being provided free of charge.
Dr Ghani assured parents that the vaccine carries no harmful side effects, aside from a possible mild fever similar to that caused by routine immunisations. He urged families to ensure their daughters receive this one-time protection against cervical cancer, a potentially fatal disease.
Mandatory consent
The education department had earlier made parental consent mandatory for administering cervical cancer prevention vaccines to schoolgirls, following strong protests from parents.
The vaccination campaign, running from September 15 to 27, targets girls aged 9 to 14. Private schools had already opted out while permission forms were distributed, and only girls whose parents provide written consent are receiving the injections.
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Drizzle makes city weather pleasant
KARACHI:The Pakistan Meteorological Department (PMD) has forecast light rain and drizzle in Karachi today (Wednesday) and Thursday, following intermittent showers in various parts of the city on Tuesday.
Due to low-level sea clouds, several areas — including Sohrab Goth, Gadap Town, Baldia, Empress Market, Garden, Golimar, Nishtar Road, Lines Area, Clifton, and Defence Housing Authority experienced light rain and drizzle.
Most parts of Sindh will remain hot and humid, though light rain is likely in some coastal districts.
Chief Meteorologist Karachi said that the city may continue to experience drizzle and light showers for the next few days, with rainfall intensity not expected to exceed 4mm. He clarified that the weather system which had earlier caused heavy rains in the city has dissipated, ruling out any chances of strong downpours.
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Lights! Camera! Chanel! Sarah Paulson, Tessa Thompson, and Meghann Fahy Fete Chanel’s Partnership With Tribeca
Two decades ago, a pivotal moment cemented Paulson’s commitment to paying it forward. “I had a wildly wonderful experience with Diane Keaton when we were making a movie called The Other Sister,” she recalled. “I was 25 years old and I didn’t know anything. I’d never had the experience of shooting something when the rest of the cast had gone home. Diane changed out of her clothes, got a glass of wine, and stayed for my off-camera and helped me. It was my first understanding of how you can really show up for other actors.”
Paulson isn’t the only one rolling up her sleeves. Fresh from the Toronto International Film Festival, Tessa Thompson joined as a conversation leader too. It’s a full-circle moment for the Los Angeles native, who paired an archival Chanel miniskirt and slingbacks with a vintage Fiona Apple concert T-shirt to meet this year’s cohort of 10 filmmakers for lunch. “Tribeca was one of the first festivals where I got to debut a piece of work by a filmmaker called Nia DaCosta. Chanel’s support—how they want to inspire women and give them a pathway to find audiences and show their work at film festivals—is really incredible,” Thompson said. “If I didn’t have mentorship from people who were interested in stories by young women of color, I literally wouldn’t have a career.”
Thompson has since reunited with DaCosta for Hedda, already drawing awards-season buzz. “We’ve had the chance to grow through friendship and collaboration,” she said. “Programs like this that give safe spaces for people to create and collaborate are vital. It can be really hard to feel a sense of community—particularly when you might be the only person of color in the room. When you’re a storyteller, you remain a student, so I’m looking forward to learning over the next few days.”
Meghann Fahy—serving as a juror for the first time—flew across the country after Sunday’s Emmy Awards. The Sirens star arrived at the Greenwich Street eatery renouncing high heels altogether—“I’m so over them,” she laughed—opting for chic, comfortable Chanel leather loafers instead. “The list of women who’ve been instrumental in my career is luckily very long,” she mused. “But working with Julianne Moore recently was such a wonderful example of how having a female leader on set makes a big difference for everyone.”
“Lucky” is also how Paulson describes working on women-led projects. She recently wrapped All’s Fair, Ryan Murphy’s high-powered divorce-lawyer drama starring Glenn Close, Naomi Watts, Teyana Taylor, Kim Kardashian, and Niecy Nash. “It was really special—phenomenal, actually. We totally bonded and got to know each other,” she said of the series, which drops in November. “I feel I’ve been really lucky to work with women. I did Ocean’s Eight with all women, and a lot of American Horror Story with wonderful female actors.” And while viewers can expect plenty of “catfights and shenanigans” on-screen, off-screen was a different story. “We were more like little puppies in a box together,” Paulson laughed.
Over a family-style Italian lunch, Rosenthal officially ushered in the program and raised a glass to the late Robert Redford and his steadfast support of independent film. “So with that, let’s keep doing what we do best,” she concluded. “Telling stories, rattling cages, breaking molds, and refusing to be ignored. Because ‘Through Her Lens,’ the world looks sharper, braver, more honest—and let’s be real—it looks a lot better dressed.”
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Thomas Frank hails ‘tough’ Tottenham display in win on Champions League return
Thomas Frank was pleased to see Tottenham grind out a “big win” on their Champions League return, but Villarreal counterpart Marcelino bemoaned the fact Xavi Simons stayed on the pitch.
An embarrassing fourth-minute own goal by Luiz Junior helped Spurs end their 923-day wait to resume participation in Europe’s elite competition with three points.
The Villarreal goalkeeper claimed Lucas Bergvall’s cross ahead of Richarlison before it spilled through his grasp and over the line. It settled a contest low on chances with only one shot on target by either team.
“Doing the tough job, that gives you a top opportunity to win games and we have proven that so far,” Frank insisted.
“I thought it was a big win. In any competition it’s good to get three points and get a good start. I’m happy with that.
“I’m happy with the clean sheet, happy with the defensive side of the game. I think we were extremely good and limited Villarreal to very little throughout the game.
“Obviously offensively we struggled on the day to create something against a good team. It was a very even game that we edged in the end.
“What I like is that our foundation is strong. Now we are four games won, three in the Premier League, one in the Champions League, and we have four clean sheets which is massive.”
Villarreal had chances to level after the mishap by Junior Luiz with a Nicolas Pepe shot deflected wide in a first half which included a squandered opportunity for Tajon Buchanan.
Marcelino watched his team push on further after the break and was frustrated home debutant Xavi avoided a second yellow card for a cynical tackle on Pepe after 66 minutes before Pepe sent an 85th-minute free-kick inches wide – after Micky van de Ven hauled down Georges Mikautadze and received only a caution from referee Rade Obrenovic.
Villarreal head coach Marcelino said: “There were two really clear actions on the field I thought that when you see the replays, it looked really clear.
“There was an accidental kick but it didn’t look like he wanted to play the ball, the first action of Xavi Simons.
“I think the player didn’t have his best day today and he was a bit of a homer, the ref.”
On the result, Marcelino added: “It was an unjust result.
“One team scored and another didn’t manage to score. I am a little bit annoyed and frustrated by the result but I am proud and happy with the performance and the image we gave to the rest of Europe.
“It’s a real shame to not get a draw. That would have been the fairest result, a draw, but the people that deserved to win were us and not Tottenham. You could see that out on the pitch.”
Xavi endured a mixed night as he combined smartly on occasions with Djed Spence, but snatched at an effort and dragged wide in the 42nd minute and could have earned a red card after half-time.
“I think there was one on that transition you could maybe discuss? Just because it looks dangerous, it can’t be a yellow all the time, but of course I understand why you ask the question,” Frank acknowledged.
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Powerful antipsychotic drugs given to dementia patients outside of guidelines, study finds
New research indicates that individuals living with dementia are being treated with potent antipsychotic medications for periods exceeding recommended guidelines.
The study further suggests that prescribed doses are often higher than advised, and the practice of stopping and then restarting these drugs is “common”.
While antipsychotics can help manage the behavioural and psychological symptoms of dementia, the National Institute of Health and Care Excellence (Nice) advises their use only for severe agitation or distress, and strictly under specialist supervision.
Analysis by experts from University College London (UCL) looked at data from 9,819 people living with dementia aged between 60 and 85, who received their first antipsychotic prescription between 2000 and 2023.
The study by UCL looked at statistics from those with dementia aged between 60 and 85 (PA) The study found initial treatments lasted seven months, exceeding the Nice guidance of one to three months.
The analysis also showed almost one in five (18%) patients were given an initial prescription higher than the minimum effective dose.
Researchers said the findings, published in the Lancet Psychiatry, “highlight a persistent gap between clinical guidelines and real-world prescribing of antipsychotics in people living with dementia, underscoring the need for interventions that prioritise safety and person-centred dementia care”.
Dr Juan Carlos Bazo-Alvarez, of UCL’s department of primary care and population health, added: “Looking at about two decades of primary care data, we found that many people with dementia remain on antipsychotics longer than guidance recommends, and that stopping and restarting treatment is common.
“These insights from routine records can help clinicians make safer, more person-centred decisions about prescribing and reviewing medication.”
Of those who started on a moderate/high dose, some 519 (29 per cent) had a moderate/high dose in all quarters of the first year of treatment.
Among patients who stopped the drugs, more than half (56 per cent) restarted medication later.
Professor Irene Petersen, of UCL’s department of primary care and population health, added: “Our research highlights that there is a substantial gap between clinical guidelines and what is happening in practice.
“Perhaps it is time we re-evaluate the guidelines once again.”
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Tottenham: ‘Clean sheet mentality’ – pragmatism proving key for Thomas Frank
Outscoring the opposition was the mentality at Tottenham last season but now the focus is on keeping out goals at the other end of the pitch.
Tuesday’s 1-0 win against Villarreal in Spurs’ Champions League opener was the fourth clean sheet they had kept in five games so far this season under Thomas Frank.
In contrast, they had kept just one at the same stage of last season, when the more attack-minded Ange Postecoglou was in charge.
“We talked a lot about ‘clean sheet mentality’ this year because we conceded a lot last year,” Tottenham midfielder Lucas Bergvall told Amazon Prime.
“They [Villarreal] did not have a shot on target, so we did a really good job.”
Defender Micky van de Ven added: “I think we are a difficult team to play against, for sure. Structure-wise we are standing really good and we all know what to do, so we’re a difficult team to beat.”
The style of Frank’s Tottenham side against Villarreal was in stark contrast to the swashbuckling football played under Postecoglou.
They were much more cautious, even after being gifted a fourth-minute opener thanks to a calamitous mistake by Villarreal goalkeeper Luiz Junior.
But their defence was excellent, with Van de Ven in particularly halting most of Villarreal’s attacks.
Even though the visitors had 10 shots, Guglielmo Vicario didn’t have a save to make throughout.
The price for that level of pragmatism was that Tottenham themselves only had one shot on target – very little for the home fans to get excited about.
“We defended really well and gave little away throughout the game against a really good Villarreal side,” Frank said.
“I think offensively we didn’t hit the highest level. There was definitely a spell second half where we decided let’s give it to the Villarreal guys and then we’ll sprint back, that’s a very good fun thing.
“It was a very even game that we just edged.”
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Apple’s Tim Cook pleased with progress on US silicon supply chain
In an interview with CNBC’s Jim Cramer, Apple CEO Tim Cook struck an optimistic tone about the iPhone maker’s progress bringing more manufacturing to the U.S., indicating that the company is making headway with a number of projects.
“Since we announced a $500 billion commitment toward the beginning of the year, we were continually working to come up with more ways to bring manufacturing into the United States,” Cook said. “It’s not really bringing it back, because that manufacturing was not here to begin with, right? And we came up with several things that we could do and do more of.”
Cook spoke with Cramer from inside Corning‘s Kentucky glass factory, where Apple has pledged $2.5 billion so the facility can make glass for all iPhones and Apple Watches. This investment is a fraction of the whopping $600 billion investment Apple has said it will make in domestic manufacturing over the next four years. In February, the company announced it would commit $500 billion, which includes funds for a new artificial intelligence server factory in Texas. In August, Apple announced it would spend an additional $100 billion on U.S. companies and suppliers.
Cook told Cramer he was “really pleased” with Apple’s efforts to stitch together an end-to-end silicon supply chain. He said he wants to scale chip production, but also pointed to Apple’s claim that the U.S. silicon supply chain is on track to produce 19 billion chips for Apple products this year. He brought up Apple’s investment in Taiwan Semiconductor‘s chip fabrication plant, which is to be the most advanced in the U.S. Cook also mentioned Apple’s deal with MP Materials for rare earth magnets.
“A lot of advanced manufacturing can be done in this country and be done competitively in this country,” Cook said.
Cook told Cramer that Apple is “in constant communication” with the Trump administration about the progress of the investments. Trump announced last month that he would impose a 100% tariff on imports of semiconductors and chips — except for companies like Apple that are “building in the United States.”
“We have a very good relationship. It’s very positive,” Cook said of the Trump administration. “And to their credit, they are focused on regulation and trying to decrease the amount of regulation that it requires to build a new factory, to build a new data center, etc.”
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Kylian Mbappé after 50th Real Madrid goal: I do what Xabi wants
Kylian Mbappé said he’s happy to follow coach Xabi Alonso’s instructions — and work hard off the ball — to “help the team win trophies” after scoring twice in Real Madrid’s 2-1 comeback Champions League win against Marseille on Tuesday.
United States men’s national team winger Timothy Weah put the visitors ahead in the 22nd minute at the Santiago Bernabéu, before Mbappé converted a penalty seven minutes later to level the score at 1-1.
Substitute Dani Carvajal — who replaced the injured Trent Alexander-Arnold after just five minutes — was sent off for a head-butt on goalkeeper Gerónimo Rulli in the second half, before Mbappé scored another penalty late on to make it 50 goals in 64 Madrid appearances.
“I feel really good. I don’t think about being one of the team’s leaders, I think about being myself, Kylian, I think about the team,” Mbappé told Movistar. “Xabi wants us to win the ball back more quickly. We have to understand what we do, and then we’re determined to do it, because we want to win.
“I do what the boss asks me to do. He wants a high block, to win the ball high up, and then we can create chances. We’ll get used to it and it will help the team win trophies. … I want to help the team, if it’s scoring goals, pressing or assists.”
Mbappé has already scored six goals this season, with four in LaLiga and now two in the Champions League.
“He has an incredible impact,” Alonso said. “The team found some Champions League spirit at the Bernabéu. … The sending off [of Carvajal] was avoidable, it’s a shame, we’ll have to talk about it.”
– Trent exit with injury during Madrid’s UCL opener;
– Mbappé fires Madrid past Marseille
– Champions League: a reminder of how the new format worksAlonso picked Rodrygo and Franco Mastantuono as his starting wingers against Marseille, with star Vinícius Júnior benched for the second time this season.
“We need Vini, Rodrygo, Franco, Brahim [Díaz],” Alonso said. “If there are private conversations, they stay at Valdebebas or in the dressing room. There will be moments for everyone. Nobody should feel offended if they don’t play a game, the calendar is very demanding.”
Mastantuono became the youngest player to start for Real Madrid in the Champions League, according to UEFA. At 18 years, 33 days old, the Argentina midfielder beat the mark set last year by Brazil striker Endrick, who was 18 years, 73 days old when he started for Madrid against Lille.
Goalkeeper Thibaut Courtois said the team’s collective approach had changed under Alonso, compared to predecessor Carlo Ancelotti.
“The problem is when you don’t defend with eleven, with the whole team,” Courtois told Movistar. “The boss now is really on top of the wingers, and Kylian, and the attacking midfielders like Arda [Güler] for example. They have to get back quickly behind the ball, and that changes a lot, that’s the difference. We have to keep doing that.”
Madrid’s next Champions League game is away at Kairat Almaty in Kazakhstan on Sept. 30, before they host Juventus on Oct. 22.
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AI Model Predicts Cardiovascular Events Risk Using Mammograms
Credit: andresr/ Getty Images Researchers in Australia at the independent global medical research institute, The George Institute for Global Health, in collaboration with the University of New South Wales and the University of Sydney, have developed a machine learning model that can analyze mammography images to successfully predict the risk of cardiovascular events in women.
Cardiovascular diseases, such as coronary artery disease, arrhythmia, and heart valve disease, and including cardiovascular events such as heart attacks and strokes, are the leading cause of death worldwide, resulting in approximately 20 million deaths each year.
Every year, around nine million women die of cardiovascular disease, but despite these high numbers, several international studies have shown that the symptoms of cardiovascular disease and cardiovascular events, as well as their risk factors, are overlooked far more often in women than in men.
For example, a 2024 study showed that women who were hospitalized with a heart attack were less likely to receive the necessary treatment and more likely to die than men.
For this reason the researchers at The George Institute for Global Health wanted to find a way to use existing data to predict the risk for cardiovascular events in women.
“It’s a common misconception that cardiovascular disease predominantly affects men, resulting in underdiagnosis and undertreatment of the condition in women,” explained co-author Clare Arnott, PhD, associate professor and global director of the cardiovascular program at The George Institute.
“By integrating cardiovascular risk screening with breast screening through the use of mammograms—something many women already engage with at a stage in life when their cardiovascular risk increases—we can identify and potentially prevent two major causes of illness and death at the same time.”
In their study, published in the journal Heart and titled “Predicting cardiovascular events from routine mammograms using machine learning,” they developed a fully automated deep learning algorithm that can analyze whole breast architecture and characteristics to predict cardiovascular risk in women who undergo routine mammography screening for breast cancer.
While the idea to use mammogram images to understand this risk is not new, studies to date have focused merely on few features in mammographic images, such as breast arterial calcification. However, this has limitations, as the risk for cardiovascular events can come from many factors. Breast arterial calcification, for example, cannot be applied as accurately to older women.
In their study, the researchers looked at mammography data from 49,196 women aged 35-94 years, with a mean age of around 60 years, and a median follow-up of 8.8 years. Of these women, 3,392 reported during their follow-up that they had experienced a first major cardiovascular event, such as atherosclerosis, heart failure, heart attack, or stroke.
The researchers trained their automated algorithm to analyze the full range of internal breast structures and characteristics from these routine mammogram images, taking into account the women’s age to predict their major cardiovascular disease risk over ten years.
They then compared their AI model with other risk scores and calculators, which need multiple data points based on known cardiovascular risk factors, including blood pressure and cholesterol.
“We found that our model performed just as well without the need for extensive clinical and medical data,” said Arnott. “Our model is the first to use a range of features from mammographic images combined simply with age—a key advantage of this approach being that it doesn’t require additional history taking or medical record data, making it less resource intensive to implement, but still highly accurate.”
As a next step, the researchers aim to validate their algorithm in more diverse patient populations, utilizing different screening practices to assess the generalizability of their AI model and to refine it further.
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