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  • Here’s How to Watch Mercury Photobomb Your 4th of July Fireworks : ScienceAlert

    Here’s How to Watch Mercury Photobomb Your 4th of July Fireworks : ScienceAlert

    July 2025 offers a fine chance to check Mercury off of your skywatcher’s life list.

    For folks in the United States, July evenings mean 4th of July fireworks. While you’re waiting for the show, be sure to watch for the most elusive of the planets as twilight falls, as Mercury shines at its very best for 2025.

    Mercury in July

    If you’ve never seen the innermost world before, now is a good time to try. This is because Mercury reaches greatest elongation, or its greatest point from the Sun as seen from our Earthly vantage point later this week.

    Orbiting the Sun once every 88 days, Mercury reaches this point six times a year, alternating from east to west, flipping from the dusk into the dawn sky.

    Related: It’s Official: NASA Confirms New Interstellar Object Is Zooming Through Solar System

    Not only is Mercury bashful, but not all elongations are created equal. These can vary by the time of the year and the season, which varies the angle of the ecliptic plane versus the horizon.

    Also, the distance Mercury sits from the Sun varies across its elongated, elliptical orbit. In July, Mercury reaches greatest elongation just 10 days prior to aphelion (its farthest point from the Sun) on July 14th.

    Look low to the west for +0.5 magnitude Mercury, about 10 degrees above the horizon 30 minutes after sunset. Fainter +1.5 magnitude Mars is the only other planet on the July dusk scene, now receding from view.

    Looking west at dusk on July 4th. (Stellarium)

    As a teaser, Mercury passes near the open cluster Messier 44 (the Beehive) on the evening of July 2nd.

    Then on Friday, Mercury is at its best dusk apparition for July on the 4th, at 26 degrees east of the Sun.

    This is one of three dusk elongations of Mercury for 2025.

    Mercury versus the Beehive cluster on the evening of July 2nd. Credit: Stellarium.
    Mercury versus the Beehive cluster on the evening of July 2nd. (Stellarium)

    And yes, Mercury is in retrograde starting on July 17th, though you won’t be able to attribute Earthly woes to this apparent motion across the sky (sorry astrologers), you can watch as the planet enters SOHO’s LASCO C3 imager on July 27th.

    Mercury then reaches inferior conjunction passing between the Earth and the Sun on the final day of the month, July 31st, and then heads into the dusk sky.

    YouTube Thumbnail allowfullscreen=”allowfullscreen” frameborder=”0″>

    Unfortunately, there’s no transit this time around… we’ll have to wait until November 13th, 2032 to see the black dot of Mercury once more cross the Sun.

    Mercury, Mars and the Moon do, however all meet up in the dusk sky for a fine triple conjunction on October 23rd.

    July also sees the International Space Station enter a span of full illumination starting on July 6th, which runs out until July 11th. Can you nab Mercury along with the local fireworks show? How about Mercury, Fireworks and the ISS?

    Probably the very best event we have in July is the occultation of the Pleiades (Messier 45) by the waning crescent Moon for North America on July 20th.

    Top astronomy events for July 2025. Credit: Dave Dickinson (@AstroDave on Blue Sky).
    Top astronomy events for July 2025. (Dave Dickinson/@AstroDave).

    Don’t expect to see much from Mercury at the eyepiece. The planet will present an 8″, half-phase disk at greatest elongation, which you can follow as it thins to a crescent and gets larger through July.

    That’s just about all anyone had seen of Mercury throughout the telescopic era, until NASA’s Mariner 10 and later MESSENGER gave us closeup views of the enigmatic world.

    Up close, Mercury looks like our Moon, sans the flat maria plains. The joint JAXA/ESA BepiColombo mission is poised to continue exploration of Mercury, when it enters orbit around the planet late next year.

    Did you know: Mercury even exhibits a comet-like sodium ion tail, as its tenuous exosphere is blown back by the intense solar wind? This finding of the modern space era has actually been captured by dedicated amateur astronomers.

    The elusive sodium tail of Mercury. Credit: Hisayoshi Kato.
    The elusive sodium tail of Mercury. (Hisayoshi Kato)

    Don’t forget to check out Mercury this coming weekend, as it leads the planetary show in the July dusk sky.

    This article was originally published by Universe Today. Read the original article.

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  • Psychiatry Updates—TRD Breakthroughs, FDA News, Latest Podcast Episodes

    Psychiatry Updates—TRD Breakthroughs, FDA News, Latest Podcast Episodes

    Before Q2, HCPLive spoke with Steve Levine, MD, from Compass Pathways, for a Q1 recap and a look ahead at what was to come in psychiatry. Now that the quarter has wrapped, we’re revisiting those expectations.

    Back in April, Levine highlighted 2 key studies to watch: Compass Pathways’ topline results for COMP360 psilocybin and Beckley Psychtech’s intranasal 5-MeO-DMT (BPL-003), both for TRD. Compass delivered on June 23, publishing phase 3 data from COMP005. A single 25 mg dose of COMP360 led to a significant reduction in depression severity at 6 weeks.

    Beckley followed with their phase 2b data on July 1. BPL-003 met its primary and secondary endpoints, showing rapid, robust antidepressant effects after a single dose.1 Patients on 8 mg and 12 mg had meaningful symptom reduction by week 8, and most were ready for discharge within 90 minutes, fitting well within the 2-hour in-clinic model.

    Along with the promising COMP360 data, this recap spotlights the unsuccessful phase 3 ARISE trial for xanomeline-trospium (Cobenfy) as an adjunctive schizophrenia treatment, an interview with John Kane, MD, on promising LB-102 data, and new podcast episodes of Medical Ethics Unpacked and the Gus Alva Perspective.

    FDA Updates

    FDA Officially Eliminates Clozapine REMS

    On June 13, 2025, the US Food and Drug Administration (FDA) officially eliminated the clozapine REMS program to improve access to this effective treatment for schizophrenia. Although monitoring for severe neutropenia remains recommended, prescribers now have sole responsibility for determining clozapine’s use. In response, the Schizophrenia & Psychosis Action Alliance and American Association of Psychiatric Pharmacists are launching A New Era in Clozapine Management this fall to support safe, stigma-free prescribing.

    What’s Moving in the Pipeline

    Compass Pathways’ COMP360 Psilocybin Shows Benefit in Phase 3 TRD Trial

    Compass Pathways announced positive topline results from its pivotal phase 3 COMP005 trial on June 23. A single 25 mg dose of COMP360 led to significant reductions in depression severity at 6 weeks among patients with TRD, meeting the primary endpoint. No major safety concerns were reported. The company plans to share 26-week follow-up data once its companion trial (COMP006) progresses.

    Cobenfy Falls Short in Phase 3 ARISE Trial as Adjunctive Schizophrenia Therapy

    In the phase 3 ARISE trial, xanomeline and trospium chloride (Cobenfy) did not achieve a statistically significant benefit as an adjunctive schizophrenia treatment. The 6-week study showed only a modest 2-point PANSS score difference versus placebo. However, subgroup analysis suggested Cobenfy may be more effective when paired with non-risperidone antipsychotics. Despite the missed endpoint, the safety profile remained favorable, and further research is encouraged.

    Interview With John Kane, MD, on LB-102

    LB-102 Significantly Improves Disease Severity in Acute Schizophrenia, with John Kane, MD

    LB-102, a novel oral benzamide antipsychotic, demonstrated significant improvement in disease severity in the phase 2 NOVA trial. Doses of 50–100 mg led to meaningful CGI-S score reductions and positive effects on PANSS scores, with minimal weight gain and extrapyramidal symptoms. Lead investigator John Kane, MD, noted its potential to address unmet needs, particularly for negative symptoms and maintenance therapy.

    Gus Alva Perspective

    Launched May 16, 2025, The Gus Alva Perspective is a clinician-focused podcast hosted by psychiatrist Gus Alva, MD, medical director of ATP Research. With new episodes twice monthly, the show offers expert commentary on treatment advances and exclusive coverage leading up to the Southern California Psychiatry Meeting.

    Featured Episodes:

    The Gus Alva Perspective: SoCal Psych Preview—Schizophrenia Updates, with Jonathan Meyer, MD

    The Gus Alva Perspective: SoCal Psych Preview—Tardive Dyskinesia, with Jonathan Meyer, MD

    The Gus Alva Perspective: SoCal Psych Preview—Metabolic Revolution in Mood Disorders, with Roger McIntyre, MD

    Medical Ethics Unpacked

    Medical Ethics Unpacked: Shifting Vaccine Regulation and Policy, with Jason Schwartz, PhD

    Jason Schwartz, PhD, of Yale, joins hosts Dominic Sisti, PhD, and Steve Levine, MD, to discuss the ethics of vaccine regulation. They examine how COVID-19 reshaped vaccine trust, amplified political divisions, and exposed vulnerabilities in public health infrastructure. The conversation addresses tensions between individual rights and collective health, misinformation’s impact, and the controversial replacement of ACIP members by HHS Secretary Robert F. Kennedy Jr.

    Medical Ethics Unpacked: Unique Ethical Challenges of Psychedelic Therapies

    Amy McGuire, JD, PhD, from Baylor College of Medicine, joins Sisti and Levine to explore the unique ethical issues in psychedelic therapy, particularly informed consent, cultural integration, and altered states of consciousness. The FDA’s recent rejection of MDMA-assisted therapy for PTSD has heightened debate over how to responsibly introduce these treatments into Western clinical practice.

    References

    atai Life Sciences and Beckley Psytech Announce Positive Topline Results from the Phase 2b Study of BPL-003 in Patients with Treatment-Resistant Depression. Beckley Psychtech. July 1, 2025. https://www.beckleypsytech.com/posts/atai-life-sciences-and-beckley-psytech-announce-positive-topline-results-from-the-phase-2b-study-of-bpl-003-in-patients-with-treatment-resistant-depression. Accessed July 1, 2025.

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  • Reconciliation Bill Closes Off Pathways to Keep Global Warming Below 1.5 C | Press Release

    “A little less than three years ago, we applauded the enactment of the Inflation Reduction Act because of all the benefits it promised to deliver,” said EESI President Daniel Bresette. “Unfortunately, the opposite applies to the reconciliation bill just passed by the Senate and House of Representatives so we have to condemn it. This legislation will increase household energy bills, put people out of work, and stall investments in clean energy technologies. Greenhouse gas emissions will increase as a result of this bill becoming law, essentially closing off the few remaining pathways to limit global warming to 1.5°C (2.7°F) to avoid the worst outcomes of climate change.”

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  • Rivals Eye Alex Palou as Summer Sprint Starts Sunday at Mid-Ohio

    Rivals Eye Alex Palou as Summer Sprint Starts Sunday at Mid-Ohio

    The path to this year’s NTT INDYCAR SERIES championship is a six-month marathon, but the final push is more of a sprint.

    Beginning this weekend at the Mid-Ohio Sports Car Course, the 27 car-and-driver combinations will face eight races over the next nine weeks. Specifically, Sunday’s The Honda Indy 200 at Mid-Ohio Presented by the All-New 2026 Passport represents the first of four races in July.

    SEE: Event Details

    The remaining schedule is as diverse as it is hectic. This month, there are two road course venues, a short oval hosting two races, and a street circuit. Overall, the rest of the season features four races on ovals, three on road courses and one on a street circuit. The champion will be awarded the Astor Challenge Cup Aug. 31 at Nashville Superspeedway.

    All told, there are 1,410 laps still be run in 2025.

    Every race has a green flag, and the one signifying the start of the season’s second half comes Sunday at Mid-Ohio. Here are five things to consider in this 90-lap race.

    Palou on a Mission

    Indianapolis 500 presented by Gainbridge champion Alex Palou (No. 10 Open Al Chip Ganassi Racing Honda) remains in control of this title pursuit, and he brings a commanding 93-point lead into this weekend’s event. In nine races held this season, Palou has won six, finishing second in another.

    Palou’s goal is to clinch a third consecutive series championship and fourth in five years, but he can also earn another significant place in the sport’s history. A.J. Foyt (1964) and Al Unser (1970) each won a record 10 races in their most successful seasons. Mario Andretti won nine races in 1969. Palou can reach or even exceed those totals.

    Palou has won five races at tracks remaining on this year’s schedule. He won at Mid-Ohio in 2023 and has a pair of race wins each at WeatherTech Raceway Laguna (site of the July 27 race) and Portland International Raceway (site of the Aug. 10 race). The Spaniard has fared particularly well at Mid-Ohio, finishing on the podium in each of his four races with Chip Ganassi Racing. He finished second last year.

    Kirkwood the Season’s Other Winner

    Not since 1980 has an INDYCAR SERIES gone this long without realizing a third driver reaching victory lane. This year, Palou has won six races, Andretti Global’s Kyle Kirkwood (No. 27 Andretti Global Honda) has won the other three.

    That means a host of drivers, including Team Penske drivers Will Power, Scott McLaughlin and Josef Newgarden, along with Arrow McLaren’s Pato O’Ward, Chip Ganassi Racing’s Scott Dixon and Andretti Global w/Curb-Agajanian’s Colton Herta, are still chasing their first season victories.

    This will be Kirkwood’s fourth series start at Mid-Ohio, and he doesn’t have a lot to show for the previous three. His best finish came last year when he crossed the line in eighth. He qualified in the third position two years ago. But he did win both 2021 INDY NXT by Firestone races on the 13-turn, 2.258-mile circuit.

    Dixon Is Mid-Ohio’s King

    Dixon is easily this series’ most accomplished driver at Mid-Ohio, winning six of his 21 starts. The driver of the No. 9 PNC Bank Chip Ganassi Racing Honda also has finished second and third once each. In 2014, he famously drove from the last starting position (22nd) to win.

    Given Dixon’s past success at Mid-Ohio, this would seem to be a good opportunity for the New Zealand driver who turns 45 later this month to extend his record streak of seasons with at least one race victory. His count is 20 consecutive years, a run that began with a late-season win in 2005 at Watkins Glen International.

    Dixon’s career total is 58 series wins, which ranks second all-time to Foyt’s 67. But Dixon is winless in the past 20 races dating to last year’s victory in Detroit. Last year at Mid-Ohio, he finished 27th after a mechanical gremlin bit him ahead of the race’s official start, and he completed only 40 laps.

    Next Winner: O’Ward? McLaughlin? Newgarden?

    If someone other than Palou or Kirkwood is going to win a race this season, it’s likely he will do so this weekend at Mid-Ohio, a track which has produced eight different winners in the past eight races.

    O’Ward won last year’s race, chasing down Palou, who had led 53 of the first 56 laps. The driver of the No. 5 Arrow McLaren Chevrolet led the final 24 laps.

    Palou won the 2023 race, and before that it was McLaughlin, Newgarden, Herta, Power, Dixon and Alexander Rossi driving to victory lane. Graham Rahal (2015) is also a former series race winner at Mid-Ohio. That makes nine former winners in this field, something no other event on the season schedule can match.

    Other Items of Interest

    Aside from the many different race winners, Mid-Ohio’s podiums have recently been predictable.

    Chip Ganassi Racing has produced the second-place finisher in each of the past four series races at Mid-Ohio. That’s Marcus Ericsson (2021), Palou (2022, 2024) and Dixon (2023). Team Penske has had the past three third-place finishes (Power in 2022 and 2023 with McLaughlin last year).

    One-two finishes by teams are also a regular occurrence at Mid-Ohio. In the series’ 138 instances since 1990, this track has had 16 of them, double the eight of the next closest (the former Belle Isle Park circuit in Detroit). Palou and Dixon were the last teammates to sweep the top two positions at Mid-Ohio, in 2023.

    This weekend’s action begins with the first practice at 4:30 p.m. ET Friday (FS2, FOX Sports app, INDYCAR Radio Network). Television airing shifts to FS1 until the race Sunday afternoon, with the second practice at 10:30 a.m. Saturday and qualifying for the NTT P1 Award beginning at 2:30 p.m.

    Sunday, the warmup practice is at 9:30 a.m. ET. The race broadcast on FOX starts at 1 p.m.


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  • Diogo Jota, Liverpool and Portugal footballer, dies aged 28 in car crash | Football

    Diogo Jota, Liverpool and Portugal footballer, dies aged 28 in car crash | Football

    The football world has been left devastated by the death of the Liverpool and Portugal star Diogo Jota in a car accident in north-western Spain. The 28-year-old father of three, who married his long-term partner, Rute Cardoso, 11 days earlier, was killed alongside his brother André Silva when the Lamborghini they were travelling in veered off a road.

    Jota and the 25-year-old Silva died at about 12.40am local time on Thursday in the province of Zamora. The cause of the accident has not been confirmed but Spain’s Civil Guard said it believed the car had sustained a puncture while overtaking, causing the driver to lose control. The Lamborghini burst into flames and firefighters had to extinguish a blaze in the surrounding vegetation caused by the accident. The wreckage of the vehicle was visible by the side of the A-52 near Cernadilla on Thursday. The brothers’ funeral will be on Saturday morning in the Gondomar area of Porto where they grew up.

    Liverpool said they were devastated and their former manager Jürgen Klopp, who signed Jota from Wolves, posted on Instagram that he was heartbroken. Klopp, a religious man, wrote: “This is a moment where I struggle! There must be a bigger purpose! But I can’t see it!” Liverpool’s head coach, Arne Slot, said Jota was “a loved one to all of us” and “the essence of what a Liverpool player should be”. Slot added: “The last time we spoke, I congratulated Diogo on winning the Nations League and wished him luck for his forthcoming wedding. In many ways, it was a dream summer for Diogo and his family, which makes it all the more heartbreaking that it should end like this.”

    Tributes were paid from across the football spectrum to Jota and Silva, a professional footballer with the second-tier Portuguese club Penafiel. Cristiano Ronaldo said the death “doesn’t make any sense. Just now we were together in the national team, just now you were married. To your family, to your wife, your children, I send my condolences and wish them all the strength in the world. I know you will always be with them. R.I.P Diogo and André. We will all miss you.”

    The site of the accident in which Liverpool player Diogo Jota and his brother died in the province of Zamora. Photograph: Emilio Fraile/AP

    Fans of varying allegiances laid flowers, football shirts and scarves in memory of Jota on a grass verge behind the Main Stand at Anfield. The Liverpool legend Sir Kenny Dalglish said: “Football is not important at this sad time. You feel helpless, knowing there’s so little we can do to ease the pain for his wife of just two weeks, his three beautiful children.” Darwin Núñez, Dominic Szoboszlai and Harvey Elliott were among the Liverpool players to post tributes. Elliott described the forward as “humble, hardworking, kind, and always there for anyone that needed anything”. The Liverpool squad are due to report back for pre-season training early next week and are scheduled to play their first friendly at Preston on Sunday 13 July.

    Jota joined Liverpool for £41m in 2020 and scored 65 goals in 182 appearances for the club. A superb finisher, known as “Jota the slotter” by Liverpool fans, he won the Premier League, FA Cup and League Cup with Liverpool and the 2018 Championship title with Wolves. He was also a two-time winner of the Nations League with Portugal. His last game was the Nations League final penalty shootout victory over Spain on 8 June. Uefa’s president, Aleksander Ceferin, said: “Just three weeks ago, I had the honour of presenting Diogo Jota with a medal after the Uefa Nations League final – a moment of joy, pride, and celebration that will now for ever be burned in memory with sorrow.”

    A map showing the location of the car crash

    Jota, who scored 14 goals in 49 Portugal appearances, was an immensely popular figure in the Liverpool dressing room. “Liverpool Football Club are devastated by the tragic passing of Diogo Jota,” said a club statement that also requested “the privacy of Diogo and André’s family, friends, teammates and club staff is respected as they try to come to terms with an unimaginable loss. We will continue to provide them with our full support.”

    Liverpool have opened a book of condolence that can be signed at Anfield until Sunday, along with a digital version. Flags at the stadium and at Liverpool town hall were lowered to half mast. The club’s stores, museums and tours have been closed until Monday.

    Tributes at Anfield in memory of Diogo Jota. Photograph: Peter Byrne/PA

    “We all feel utterly bereft right now,” said Michael Edwards, the chief executive of football at Fenway Sports Group, Liverpool’s owner, and Richard Hughes, the club’s sporting director, in a statement. “As his teammates, friends and colleagues, we are consumed by shock and sorrow. We know our supporters, his national team, former clubs and teammates and the wider football community share in this grief. This is a tragedy that transcends Liverpool Football Club.

    “In the coming days, we as a club will look to honour our beloved No 20 with the respect and affection he so richly deserves. We will strive to make these tributes meaningful and inclusive of our supporters, to whom Diogo meant so much. For now, we express a love that is filled with deep sorrow and pain. We have lost someone truly irreplaceable. Rest in peace, Diogo. YNWA.”

    Jota and his partner were married in Porto on 22 June and announced the news in an Instagram post a few days ago. On Monday Rute shared more pictures from their wedding day and wrote: “My dream came true.” Jota commented: “I’m the lucky one.” They had met in high school and started going out in 2013, a year before he turned professional. The couple have three young children: Denis, Duarte and a daughter born last year whose name has not been revealed.

    The British prime minister, Keir Starmer, and his Portuguese counterpart, Luís Montenegro, expressed sympathy for Jota, Silva and their families. Angela Raynor, the deputy prime minister, paid her respects at Anfield while on government business in Liverpool.

    Diogo Jota with the trophy after winning the Nations League last month. Photograph: Annegret Hilse/Reuters

    Portugal’s president, Marcelo Rebelo de Sousa, said: “Diogo Jota represented Portuguese football at the highest level and demonstrated a high level of professionalism and dedication as part of a generation that has taken Portuguese football to the highest level. The president sends his deepest condolences to his family, friends and professional colleagues for a loss that has dismayed all Portuguese.”

    Pedro Proença, the president of the Portuguese FA, wrote on social media: “We have lost two champions. The passing of Diogo and André Silva represents irreparable losses for Portuguese football and we will do everything we can to honour their legacy every day.”

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  • ‘Nobu’ review: Less about the sushi master, more about a sexy global brand

    ‘Nobu’ review: Less about the sushi master, more about a sexy global brand

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    It takes a little over an hour for “Nobu” to marinate long enough to approach a point of complexity, not exactly bitter but no longer cloyingly sweet. Nobu Matsuhisa, the celebrated sushi master, is running quality-control checks in one of his restaurants. A poor chef is sweating the test so badly, he won’t need soy sauce soon enough. His dish keeps being sent back: Chop the chives finer. Why is this pile of raw crudo smaller? Why did you paint a line of salt instead of a dot? The scene goes on, excruciatingly. A few minutes later, Robert De Niro — an early investor and co-founder — dominates a private board meeting with concerns about too-rapid growth. It’s not quite the ominous Waingro showdowns of “Heat” but in the ballpark.

    Fastidiousness, precision and a kind of reputational exclusivity are at the heart of Matsuhisa’s enterprise. These are hard things to make a documentary about. But it’s also why Nobu needed to come to Beverly Hills for his concept take root — not just any Los Angeles but the ’80s-era boomtown of power lunches and spend-to-impress dining. Spago’s Wolfgang Puck makes an appearance in director Matt Tyrnauer’s half-interesting film, fawning over his longtime friend sitting next to him but not quite articulating the essence of their revolution: high-end branding. You wish more time was spent on that conceptual idea, enabled by celebrities throwing around money on food they barely ate.

    The kind of doc that “Nobu” more often resembles (as do most foodie-targeted profiles) is a gentle chronology of a humble genius and everyday guy who just happens to fly private. Matsuhisa bows to euphoric local fishmongers, does a lot of hugs and selfies with his staff, visits his roots in Japan and Peru. There are family interviews and a detour to Alaska, where, years before he had a 300-person nightly waitlist, an early restaurant of his caught fire — in the bad literal way (Tyrnauer cuts to the Anchorage newspaper headline). These false starts are somehow exhausting, lacking in suspense. He contemplated suicide, then came to California.

    The food sails by: wedges of black cod with miso, delicate plates of thinly sliced fish adorned with tweezer-manipulated herbs. All of it is crazy-making and delicious. Still, apart from former Los Angeles Times food editor Ruth Reichl, who witnessed the rise of Nobu as it happened, there are few on-camera voices who speak directly to Matsuhisa’s gifts and experimentation with form. 2011’s “Jiro Dreams of Sushi” does a better job of delivering the intimate discipline of cutting and shaping. More testimony to the experience of eating at Nobu would have helped this feel less like a commercial.

    “Nobu” is a film oddly unconcerned with the communal experience of dining. We hear about the way his sushi workstations are elevated (a “stage,” Matsuhisa calls them) and that’s central to the performance going on here, also the remove. Something clicks when the film heads to Nobu Malibu and visits the table of supermodel Cindy Crawford, whose “Cindy rice,” a dish he invented for her, adorns the menu. There’s a deep mutual gratitude between them that goes back years. An appreciation of the finer things? No doubt. Game recognizing game? Definitely.

    ‘Nobu’

    In English and Japanese, with subtitles

    Not rated

    Running time: 1 hour, 50 minutes

    Playing: Laemmle Monica

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  • Jack Draper out of Wimbledon in second round as Marin Cilic’s grass pedigree triumphs

    Jack Draper out of Wimbledon in second round as Marin Cilic’s grass pedigree triumphs

    THE ALL ENGLAND CLUB, LONDON — For Jack Draper, Wimbledon remains a conundrum. The great home hope fell in the second round on No. 1 Court for a second straight year, this time losing 6-4, 6-3, 1-6, 6-4 against the world No. 83 and former finalist Marin Čilić.

    Those two early exits bookend an otherwise very impressive 12 months of Grand Slam performances for the world No. 4, with runs to the semifinals at the U.S. Open and then fourth-round appearances in Melbourne and Paris.

    It would be easy to attribute his Wimbledon defeats to the strain of being Britain’s highest-ranked player — pressure Draper has continually played down — but like last year’s defeat to Cameron Norrie, Draper again struggled to impose his game on home turf. Normally so nimble, Draper has looked a little heavy-legged here, as though not quite sure yet how to best maneuver his bulky 6 feet 4 inches (193 cm) frame across the grass.

    Čilić, 36, is fresh from winning an ATP Challenger title in Nottingham and knows the intricacies of this surface. He reached the Wimbledon final in 2017 and won the prestigious warm-up tournament at Queen’s in 2012 and 2018. He displayed all of that grass-court pedigree against Draper, dominating from the baseline and neutralizing Draper’s power. His stronger wing is his backhand, which caused Draper a big problem. The Brit’s favored serve from the ad court swings out to the right-hander’s backhand, and it’s generally a devastating weapon. Not so against Čilić, who could handle it with his favorite shot, winning the first set with a return winner off his backhand.

    Čilić’s forehand is much more up and down, but when it works, it can be lethal. It flew through the court at times here, augmented by a brilliant serving display that took in 16 aces and an 88 percent win-rate on first-serve points in the first two sets. Most importantly, Čilić was able to get on the front foot. In the first couple of sets, he spent 25 percent and then 28 percent of the time in attack, compared to 16 percent in both for Draper — a huge drop-off from his average in the past year of 26 percent.

    Draper flipped this in the third set, when it felt as though the momentum of the match might be about to turn. He finally broke for the first time and then raced away with the set, harnessing the energy of a crowd who enjoyed seeing their adversary for the day getting a time violation down break point.

    Čilić wasn’t rattled by the home fans getting on his back. He refocused and got back on the front foot, attacking in 27 percent of the fourth set compared to Draper’s 21 per cent. His movement was impressive too — even when he was younger, before two knee operations, he rarely chased down drop shots like he did against Draper. Čilić’s injuries have been so persistent that this summer’s tournament is his first Wimbledon appearance since 2021.

    Draper clung on to save two break points down 3-4, but a few games later, it was all over. Čilić forced a missed backhand to claim a memorable victory that further opens up a tournament defined by upsets on the men’s and women’s sides. Novak Djokovic, the seven-time champion, and Jakub Menšík, the world No. 17, are the two highest seeds left in Draper’s quarter.

    For Čilić, it is a statement win after fearing that his career would be over following a second knee operation in May last year.

    Draper will be monumentally disappointed, but he has made great strides in so many areas over the past year. He has climbed up from No. 40 to become a fixture in the world’s top five, winning a Masters 1,000 title, the level just below Grand Slams, along the way.

    Until next year at least, this home major continues to be his kryptonite.

    (Photo: Hannah Peters / Getty Images)

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  • Hepatitis E virus also attacks organs other than the liver, study finds

    Hepatitis E virus also attacks organs other than the liver, study finds

    A research team from Bochum and Hannover shows that the hepatitis E virus also attacks organs other than the liver.

    The hepatitis E virus (HEV) causes severe liver inflammation. A research team from Ruhr University Bochum, Germany, and TWINCORE, the Centre for Experimental and Clinical Infection Research in Hannover, has now been able to prove for the first time that it can also infect kidney cells and replicate there. Antiviral drugs such as ribavirin are less effective there than in the liver. The results of the study have now been published in the journal Liver International on June 27, 2025.

    Entire life cycle possible in the kidney

    Hepatitis E viruses mainly infect liver cells and cause the most damage in the liver. “However, it was already known that they can go down the wrong path and infect other cells, such as nerve cells,” says last author Dr. André Gömer from the Department of Molecular and Medical Virology at Ruhr University Bochum.

    The team from Bochum and Hannover has now succeeded in proving in cell culture that the viruses also infect kidney cells and can multiply with their help. “The entire replication cycle of the virus takes place in kidney cells in the same way as in liver cells,” says Gömer.

    The infected kidney cells responded less well to treatment with the antiviral drug ribavirin than the liver cells. “This is probably due to the significantly different metabolic profiles of the two organs,” says Gömer. In the kidney, the virus is therefore relatively insensitive to drug treatment.

    “It could be that in chronic infections, the kidney acts as a reservoir from which the viruses spread again after a supposedly successful treatment,” says Nele Meyer, a PhD student in the Translational Virology research group at TWINCORE. She and the physician Avista Wahid are the first authors of the study. Such a reservoir could also enable the viruses to adapt better to treatment.

    Evolution in the organ

    The team also conducted a comparative genetic analysis of hepatitis viruses from chronically infected patients using their blood plasma, stool and urine. While viruses are mainly excreted from the liver in the stool, those from the kidneys are found in the urine. ‘The viruses found in the different samples differ significantly from each other,” reports Dr Patrick Behrendt, head of the Translational Virology group at TWINCORE and also last author of the article. “This indicates that the populations have been developing independently of each other for some time and have undergone a kind of evolution in the respective organ.”

    The hepatitis E virus

    The hepatitis E virus (HEV) is the main cause of acute viral hepatitis. After the first documented epidemic outbreak in 1955 to 1956, more than 50 years passed before researchers began to focus intensively on the topic. Acute infections normally heal themselves in patients with an intact immune system. In patients with a reduced or suppressed immune system, such as organ transplant recipients or HIV-infected patients, HEV can become chronic. HEV is also particularly dangerous for pregnant women.

    Funding

    The work was supported by the German Center for Infection Research, the Volkswagen Foundation, the German Research Foundation (398066876/GRK 2485/2 and 448974291) and the Federal Ministry of Education and Research (VirBio project, funding code: 01KI2106).

    Source:

    Journal reference:

    Wahid, A., et al. (2025). Extrahepatic Replication and Genomic Signatures of the Hepatitis E Virus in the Kidney. Liver International. doi.org/10.1111/liv.70183.

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  • NIH Study Links Particulate Air Pollution to Increased Mutations in Lung Cancers Among Nonsmokers

    NIH Study Links Particulate Air Pollution to Increased Mutations in Lung Cancers Among Nonsmokers

    Scientists at the National Institutes of Health (NIH) and their colleagues at the University of California, San Diego, have found that fine-particulate air pollution, which includes pollution from vehicles and industry, was strongly associated with increased genomic changes in lung cancer tumors among people who have never smoked.

    By assembling the largest-ever whole-genome analysis of lung cancer in individuals who have never smoked, researchers were able to link air pollution exposure to increased cancer-driving and cancer-promoting genetic mutations. This could potentially lead to more prevention strategies for never-smokers.

    Researchers analyzed lung tumors from 871 never-smoker patients across 28 geographic locations worldwide as part of the Sherlock-Lung study They found associations between air pollution exposure and changes in the TP53 gene, and other genetic mutational signatures previously associated with tobacco smoking. They also observed a relationship between air pollution and shorter telomeres, which are sections of DNA found at the end of chromosomes. Telomeres shorten naturally with age and shorter telomeres are related to cells inability to continue to replicate. However, scientists found fine particulate air pollution was linked to premature shortening of telomeres.

    Prior genomic studies of lung cancer have focused on tobacco smokers, leaving a significant gap in our understanding of how lung cancer develops in people who have never used tobacco. By beginning to uncover the mechanisms through which tissues acquire cancer-causing or cancer-promoting mutations following environmental exposures, this study helps scientists better understand the primary drivers of lung cancer in this population—which represents up to 25% of all lung cancer cases globally.

    Interestingly, the researchers found that while exposure to secondhand smoke was associated with slightly higher mutation burdens and shorter telomeres, compared to tumors in patients who were not exposed, it did not lead to an increase in cancer-driving mutations or mutational signatures. This suggests that secondhand smoke may have a lower overall ability to cause genetic mutations, known as mutagenicity, compared to air pollution.

    This work was led by researchers at NIH’s National Cancer Institute and the University of California, San Diego, and published in Nature on July 2, 2025.

    This news release was published by the National Institutes of Health on July 2, 2025.


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  • NDMA issues new alert for heavy rain, storms across country

    NDMA issues new alert for heavy rain, storms across country

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    ISLAMABAD:

    The National Disaster Management Authority (NDMA) has issued a nationwide weather alert, warning of heavy rain, thunderstorms, and the possibility of flooding across Pakistan from July 6 to July 10.

    According to the NDMA, cities in provinces will experience significant weather disturbances. Islamabad, Rawalpindi, Attock, Jhelum, Chakwal, Mianwali, Sargodha, Khushab, Gujranwala, Gujrat, Faisalabad, Lahore, Kasur, and Okara are expected to see rain accompanied by gusty winds and thunderstorms.

    In southern Punjab, heavy winds with rain are predicted in Multan, Khanewal, Bahawalpur, Bahawalnagar, Rahim Yar Khan, and Dera Ghazi Khan.

    Khyber-Pakhtunkhwa is also at risk, with regions like Dera, Swat, Chitral, Kohistan, Shangla, Buner, Battagram, Swabi, Nowshera, Charsadda, Malakand, Mansehra, Abbottabad, Peshawar, Mardan, Haripur, Bannu, and Kohat likely to see thunderstorms and heavy rain.

    In the northern areas of Gilgit-Baltistan, heavy rainfall is anticipated in Skardu, Hunza, Astore, Diamer, Ganche, Shigar, Muzaffarabad, Neelum Valley, Rawalakot, Haveli, and Bagh, with a high risk of flooding in these regions.

    Meanwhile, the provinces of Sindh and Balochistan are not exempt from adverse weather conditions. Cities such as Sukkur, Nawabshah, Kashmore, Hyderabad, Karachi, Tharparkar, Mirpur Khas, Umerkot, Sanghar, Jamshoro, Tando Allahyar, Thatta, Badin, Mithi, Ghotki, Khairpur, Shikarpur, Larkana, Jacobabad, and Dadu are expected to receive heavy rain, with the urban flooding expected.

    In Balochistan, areas like Quetta, Zhob, Ziarat, Kalat, Khuzdar, Awaran, Barkhan, Jafarabad, Kohlu, Sibi, Dera Bugti, Loralai, Lasbela, and Naseerabad are on alert for rainfall.

    Read More: Flash floods, heavy rain kill 64 in a week

    The NDMA has cautioned the public to stay away from weak structures, brick walls, electric poles, and billboards during storms and heavy winds, as they pose a significant risk.

    It also warned that visibility could be reduced, leading to potential accidents. Flash floods may occur, especially in local streams, so the public is advised to exercise caution.

    “Authorities have been instructed to ensure preparedness for any emergency situations,” an NDMA spokesperson said. “Citizens are encouraged to use the Pak NDMA Disaster Alert App for updates and guidance on the weather conditions and potential hazards.”

    As Pakistan braces for severe weather, the NDMA is urging citizens to stay informed and follow safety guidelines to minimise the risk of casualties and damage from storms, flooding, and other weather-related hazards.

    Also Read: Construction along Swat River diverted water flow, leading tourists into danger: report

    Flash floods and heavy rain have killed 64 people and injured 117 in a week across the country, a government agency said on Wednesday.

    The highest toll was in K-P, with 23 dead including 10 children, the National Disaster Management Authority said. Fourteen of the victims were swept away in a flash flood in the Swat Valley last week, local media reported.

    Flash floods and homes collapsing in heavy rain killed 21 others in the eastern province of Punjab, including 11 children, the authority said. In Sindh, 15 were killed, while five people died in southwestern Balochistan.

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