WASHINGTON, D.C. — As artificial intelligence continues to develop and grow in capability, Americans say the government should prioritize maintaining rules for AI safety and data security. According to a new nationally representative Gallup survey conducted in partnership with the Special Competitive Studies Project (SCSP), 80% of U.S. adults believe the government should maintain rules for AI safety and data security, even if it means developing AI capabilities more slowly.
In contrast, 9% say the government should prioritize developing AI capabilities as quickly as possible, even if it means reducing rules for AI safety and data security. Eleven percent of Americans are unsure.
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Majority-level support for maintaining rules for AI safety and data security is seen across all key subgroups of U.S. adults, including by political affiliation, with 88% of Democrats and 79% of Republicans and independents favoring maintaining rules for safety and security. The poll did not explore which specific AI rules Americans support maintaining.
This preference is notable against the backdrop of global competitiveness in AI development. Most Americans (85%) agree that global competition for the most advanced AI is already underway, and 79% say it is important for the U.S. to have more advanced AI technology than other countries.
However, there are concerns about the United States’ current standing, with more Americans saying the U.S. is falling behind other countries (22%) than moving ahead (12%) in AI development. Another 34% say the U.S. is keeping pace, while 32% are unsure. Despite ambitions for U.S. AI leadership — and doubts about achieving it — Americans still prefer maintaining rules for safety and security, even if development slows. This view aligns with their generally low levels of trust in AI, which is correlated to low adoption and use.
Only 2% of U.S. adults “fully” trust AI’s capability to make fair and unbiased decisions, while 29% trust it “somewhat.” Six in 10 Americans distrust AI somewhat (40%) or fully (20%), although trust rises notably among AI users (46% trust it somewhat or fully).
Among those who favor maintaining rules for AI safety and data security, 30% trust AI either somewhat or fully, compared with 56% among those who favor developing AI capabilities as quickly as possible.
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Robust Support for Shared Governance and Independent Testing
Almost all Americans (97%) agree that AI safety and security should be subject to rules and regulations, but views diverge on who should be responsible for creating them. Slightly over half say the U.S. government should create rules and regulations governing private companies developing AI (54%), in line with the percentage who think companies should work together to create a shared set of rules (53%).
Relatively few Americans (16%) say each company should be allowed to create its own rules and regulations. These findings indicate broad support for both government and industry standards.
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People are more emphatic about peer testing and evaluating the safety of AI systems before they are released. A majority (72%) say independent experts should conduct safety tests and evaluations, significantly more than those who think the government (48%) or each company (37%) should conduct tests.
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Multilateral Advancement Preferred to Working Alone
The spirit of cooperation extends to how people think the U.S. should develop its AI technology. Americans favor advancing AI technology in partnership with a broad coalition of allies and friendly countries (42%) over collaborating with a smaller group of its closest allies (19%) or working independently (14%).
This preference for AI multilateralism holds across party lines. Although Democrats are nearly twice as likely as Republicans (58% vs. 30%, respectively) to favor the U.S. collaborating with a larger group of allies, Republicans still favor working with either a large or small group of allies over working independently (19%).
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Bottom Line
Findings from Gallup’s research with SCSP highlight important commonalities in how Americans wish to see AI governance evolve. Americans favor U.S. advancement in developing AI while also prioritizing maintaining rules for AI safety and data security. Majorities favor government regulation of AI, company collaboration on shared rules, independent expert testing, and multilateral cooperation in development. As policymakers and companies chart the future of AI, public trust — which is closely tied to adoption and use — will play an important role in advancing AI technology and shaping which rules are maintained.
Read the full Reward, Risk, and Regulation: American Attitudes Toward Artificial Intelligence report.
Stay up to date with the latest insights by following @Gallup on X and on Instagram.
We’re nearing the end of the current lunar cycle, with the New Moon just days away. The lunar cycle is a 29.5-day series of eight unique phases of the moon’s visibility. Right now, we’re on day 25. According to NASA, these different phases happen as the Sun lights up different parts of the moon whilst it orbits Earth, so let’s see what’s happening with the moon tonight, Sept. 17.
What is today’s moon phase?
As of Wednesday, Sept. 17, the moon phase is Waning Crescent, and it is 18% lit up to us on Earth, according to NASA’s Daily Moon Observation.
Visibility is low right now, due to the percentage of the moon that is lit up, but you can still see various features on the moon’s surface. With no visual aids, you can still catch a glimpse of the Aristarchus Plateau and Kepler Crater. If you have binoculars, you’ll also see the Grimaldi Basin and the Gassendi Crater. With a telescope, add the Reiner Gamma to your list of things to spot.
When is the next full moon?
The next full moon will be on Oct. 6. The last full moon was on Sept. 7.
What are moon phases?
According to NASA, moon phases are caused by the 29.5-day cycle of the moon’s orbit, which changes the angles between the Sun, Moon, and Earth. Moon phases are how the moon looks from Earth as it goes around us. We always see the same side of the moon, but how much of it is lit up by the Sun changes depending on where it is in its orbit. This is how we get full moons, half moons, and moons that appear completely invisible. There are eight main moon phases, and they follow a repeating cycle:
New Moon – The moon is between Earth and the sun, so the side we see is dark (in other words, it’s invisible to the eye).
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Waxing Crescent – A small sliver of light appears on the right side (Northern Hemisphere).
First Quarter – Half of the moon is lit on the right side. It looks like a half-moon.
Waxing Gibbous – More than half is lit up, but it’s not quite full yet.
Full Moon – The whole face of the moon is illuminated and fully visible.
Waning Gibbous – The moon starts losing light on the right side.
Last Quarter (or Third Quarter) – Another half-moon, but now the left side is lit.
Waning Crescent – A thin sliver of light remains on the left side before going dark again.
A team of researchers, led by the Peter Doherty Institute for Infection and Immunity (Doherty Institute), explored the cellular and molecular interactions revealing how lymph nodes play a crucial role in the fight against chronic infection and cancer.
The research, published across two papers in Nature Immunology, showed that lymph nodes provide the right environment for stem-like T cells, an important type of immune cell, to survive, multiply and produce killer cells that can fight cancer or viruses. In other immune organs, such as the spleen, these cells don’t develop or proliferate as effectively, making lymph nodes essential for a strong immune response and successful immunotherapy.
The University of Melbourne’s Professor Axel Kallies, Laboratory Head at the Doherty Institute and senior author of both papers, said the findings have important implications for cancer therapy.
Lymph nodes aren’t just passive waiting rooms for immune cells, they actively train and educate T cells, and send them off to do their job.”
Professor Axel Kallies, Laboratory Head, Doherty Institute
“Our research suggests that removing lymph nodes during cancer surgery, a common practice to prevent tumour spread, may inadvertently reduce the effectiveness of treatments, such as checkpoint blockade and CAR T cell therapies. Preserving lymph nodes could strengthen immune responses and increase the effectiveness of immunotherapy.”
This work may also help explain why some patients respond better to immunotherapy than others. The state and function of lymph nodes influence how well the immune system can produce cancer-fighting T cells, directly impacting the success of immunotherapy.
The University of Melbourne’s Dr Carlson Tsui, Postdoctoral Researcher at the Doherty Institute and first author of one of the papers, said the findings could help to develop new strategies to make immunotherapy more effective.
“Our research identifies molecular signals that are involved in the regulation of stem-like cells and in their capacity to produce effective killer cells. These findings could guide the development and refinement of immune-based treatments for cancer and chronic infection,” said Dr Tsui.
“Furthermore, our research shows that rather than only focusing on the tumour itself, therapies should also be designed to preserve and enhance lymph node function. By targeting these critical immune hubs, we could boost the body’s natural ability to fight cancer, increase the effectiveness of existing immunotherapies and help more patients respond to treatment.”
Together, the two peer-reviewed papers provide a deeper understanding of how lymph nodes shape immune responses. While they are based on work with animal models, they will guide future treatment strategies for chronic infection and cancer treatment.
Professor Shahneen Sandhu, Research Lead for the Melanoma Medical Oncology Service at the Peter MacCallum Cancer Centre, commented on the clinical implications of this work.
“While this research was done in the laboratory with pre-clinical models, we’re excited to study these findings in clinical samples from patients receiving immune checkpoint inhibitors, as part of an ongoing Melanoma Research Victoria collaboration with Professor Kallies,” Professor Sandhu said.
“Combining clinical and preclinical studies will help us translate these discoveries from bench to bedside and back, ultimately improving outcomes for cancer patients.”
Source:
Journal reference:
Tsui, C., et al. (2025). Lymph nodes fuel KLF2-dependent effector CD8+ T cell differentiation during chronic infection and checkpoint blockade. Nature Immunology. doi.org/10.1038/s41590-025-02276-7.
A recent study published in the Proceedings of the National Academy of Sciences introduces a new approach to coordinating swarms of robots—one that mimics how animals like birds, bees, and fish behave in nature. The method could improve how robotic swarms are used in real-world applications such as search-and-rescue operations, wildfire tracking, or even targeted drug delivery.
According to TechXplore, at the core of the research is a concept the scientists call “curvity”—a physical property that determines how an individual robot moves in response to external forces. Much like electric charges can be positive or negative, robots in this model are designed with either a positive or negative curvity. This determines whether they are drawn to or repelled from others in the swarm, influencing whether they form tight clusters, flow in one direction, or spread out.
Unlike traditional approaches that rely on central control or complex communication between units, this system is decentralized. Each robot operates independently based on simple geometric rules, similar to the self-organizing behavior seen in animal groups. These rules were derived using principles from natural computation and basic mechanics, making them relatively easy to implement in physical systems.
The researchers tested their theory using both simulations and small-scale robot swarms. Results showed that the curvity-based rules worked not just at the level of individual robot pairs, but scaled up effectively to thousands of units acting together.
What sets this framework apart is its simplicity. Because it’s rooted in the geometry and mechanics of how the robots are built, rather than software or external coordination, it could be adapted for use in a wide range of swarm robotics applications—whether on the ground, in the air, or even inside the human body.
The study repositions swarm control as a materials design challenge rather than a software one, opening new possibilities for robotics in both industrial and biomedical settings.
If you like playing daily word games like Wordle, then Hurdle is a great game to add to your routine.
There are five rounds to the game. The first round sees you trying to guess the word, with correct, misplaced, and incorrect letters shown in each guess. If you guess the correct answer, it’ll take you to the next hurdle, providing the answer to the last hurdle as your first guess. This can give you several clues or none, depending on the words. For the final hurdle, every correct answer from previous hurdles is shown, with correct and misplaced letters clearly shown.
An important note is that the number of times a letter is highlighted from previous guesses does necessarily indicate the number of times that letter appears in the final hurdle.
If you find yourself stuck at any step of today’s Hurdle, don’t worry! We have you covered.
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Hurdle Word 1 hint
To surrender.
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Hurdle Word 1 answer
YIELD
Hurdle Word 2 hint
Strength.
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Hurdle Word 2 Answer
POWER
Hurdle Word 3 hint
To jump for joy.
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Hurdle Word 3 answer
EXULT
Hurdle Word 4 hint
Subtract.
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Hurdle Word 4 answer
MINUS
Final Hurdle hint
A fast food option.
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Hurdle Word 5 answer
COMBO
If you’re looking for more puzzles, Mashable’s got games now! Check out our games hub for Mahjong, Sudoku, free crossword, and more.
Corinna Dean has a thing for “ugly” buildings — industrial relics, cold war oddities, pillbox military defences and agricultural remnants that many see as a blight on Britain’s bucolic landscapes. This passion bloomed when the architectural curator and lecturer was a child, during car journeys down the coastal stretch of the A1 from Edinburgh. She found herself transfixed by the Torness Power Station reactor hall as it shimmered in the sunshine in an eerily flat landscape. “My mother would teasingly point out, ‘There’s Corinna’s favourite building’ every time we passed,” she says.
Dean, an artist and lecturer in architecture at the University of Westminster, later travelled the UK and Europe to document such overlooked buildings, producing two volumes of a book named Slacklands in reference to the neglected land around these often abandoned sites. “I wanted to encourage people to re-evaluate the aesthetics of our rural landscapes,” she explains. “It’s the anti-picture postcard view.”
You’d be forgiven for thinking work hasn’t begun on their conversion, so discreet is the transformation. But step through the metal threshold, and you find a home far cosier than the exterior would imply
Dean and her partner Marcus Lee, founder of architecture studio LEEP, recently found their own slackland — a concrete, metal and weed-strewn paradise in the Suffolk countryside. At its centre were four defunct agricultural buildings: a Grade II-listed, c16th-century timber barn, two galvanised steel grain sheds and a silo that creaked in the wind. When they bought the plot in 2021, the barn had planning permission for conversion into a family home. But it was the metal chutes, steel grain drums and rusty panels of the newer buildings, likely from the 1960s, that held the real charm for the couple. “They’re very basic farm buildings, but they have this rich patina and history that you can’t recreate,” says Lee.
Today, as you rattle your way down the bumpy farm track, you’d be forgiven for thinking work hasn’t begun on their conversion, so discreet is the transformation. But once you step through the metal threshold, you find a home far cosier than the exterior would imply. With exposed timber beams and pillars, textiles lining the walls, minimal ply kitchen cupboards, orange sofas and a wood-burning stove, it has a stripped-back mid-century style that exudes a laid-back warmth, much like the owners. Full-length windows throughout mean it is never dingy.
The process wasn’t without its problems. A planning officer told them the structures would have to be pulled down due to the harm their close proximity could cause to the 16th-century barn — a ruling that they felt was “part of this general prettification of the countryside at the expense of its agricultural character”, says Lee. “We managed to convince them that given the climate crisis and the embodied carbon in the building materials, demolition without considering their potential wouldn’t be a good thing. Our aim was to retain as much as we could, while making the site a place we could live.”
Instead they agreed to go down the Class Q permitted development route for the metal barns, which allows for the conversion of farm buildings into “dwelling houses” without full planning permission. Class Q requires the agricultural qualities of buildings and their surroundings to be retained, but cannot be applied to listed structures. (The couple have kept the wooden barn unchanged, save for a new roof; it now stores timber salvaged from one of Lee’s London projects.)
A centuries-old pond was full of car windscreens and rusting metal when the couple moved in
The interior was in a dilapidated state before the couple inserted a new building into the structure
Lee and Dean camped in one of the grain sheds while planning the design. One source of inspiration was the black-and-white photographs of grain elevators, water towers and barns by German duo Bernd and Hilla Becher, which celebrate the sculptural profiles of these vernacular structures, as well as the light-touch renovation projects of French practice Lacaton & Vassal — a “quiet architecture”, says Dean. “They try not to remove much.”
Their “agri-industrial approach”, as they call it, became a delicate exercise in subtraction and addition. One grain shed remains untouched, acting as an outdoor living area and a garage for Lee’s vintage Saabs. In the other, they inserted a new Douglas fir-framed pavilion inside the shell, removing just a few panels of the original structure to allow sunlight to reach the solar panels on the new flat roof inside. The largely prefabricated, larch-clad pavilion is shorter than the length of the shed, allowing space for a porch at one end and a glazed winter garden at the other — “a peaceful sanctuary where I plan to sit and read”, says Dean. It has become their main home, though they retain a base in London.
Lee, a self-described modernist, has built several new homes for himself over the years, alongside converting existing buildings. Like his timber 2005 Framehouse in east London, which won a RIBA award for architectural excellence, the two-bedroom pavilion has no load-bearing internal walls, so it can be easily reconfigured. “It’s about allowing flexibility, because who could have predicted Covid and the shift to working from home?” he asks.
The architect also organises spaces into “served and servant” areas, a tactic he learnt from 21 years working at the Richard Rogers Partnership (RRP), where his projects included London’s Lloyd’s Building and terminals for Heathrow and Madrid Barajas airports. “It’s a way of bringing some rigour to a design,” he says. In this case, he dissected the pavilion with a service wall — concealing washing machines and the boiler behind plywood joinery in an artful zigzag formation. A coffee table in the open-plan living area is topped with a piece of rolled glass left over from the construction of the Lloyd’s Building; it sparkles in the sunlight.
The couple gave the silo — now a guest annexe and workspace — a lighter touch. They removed a vast metal grain-drying drum to open up the space, and added glazing to the east and west sides. They also made a feature of one of the building’s enormous grain storage underbellies by retaining the see-through metal mesh floor. Walls are lined in SisalTech insulation, made from recycled sisal and waste wool from Harris Tweed, its cosy texture left partially exposed. “It makes the space both feel and look warm,” says Dean. They retained defunct metal light switches, sockets and the old grain elevators encased in wooden columns. “I was nervous about taking away too much,” she adds. A guest bedroom is walled off by a simple wooden frame.
Where possible, they have reused any metal that they had to remove. Corrugated wall panels are refashioned as plant boxes and sections of the silo’s drum have been reimagined as curved outdoor chairs. Other parts of the drum, including a huge pipe, now poke up from clumps of sedge: along with found agricultural objects, they make up what the couple half-seriously dub their “sculpture garden”.
All the buildings overlook a centuries-old horse pond, created to quench the thirst of working animals. (Few examples remain, as many have been filled in to make space for agriculture.) “It was full of car windscreens and rusting metal when we moved in,” says Dean. They bought a small canoe on eBay to pull them out and remove the green blanket of duckweed that was stifling aquatic life.
To boost the ecology of the pond, Dean took cues from her recent work with a charity to help decontaminate London’s River Lea, adding floating reed beds to offer a nesting place for moorhens. Dean is also influenced by French botanist and gardener Gilles Clément’s belief that neglected or unmanaged spaces (road edges, abandoned factories, wastelands, for example) are vital reservoirs of biodiversity. “Rather than introducing lots of new species, I’ve just used flints from the fields to suppress an overabundance of nettles, removed small patches of concrete and enhanced the conditions for nature to take hold,” she adds.
Wild hops now trail over decking made from a fibreglass mesh that was reclaimed from a data centre, and marsh marigolds thrive at the water’s edge — although Dean has planted some drought-tolerant euphorbias and sedums for a dash of formality in the courtyard beside the barn. “It’s never going to look manicured,” she says. “Nor will the barns or landscape ever be ‘finished.’”
The project is about challenging notions of beauty and an unspoilt rural arcadia. They hope that their home will inspire others to take slices of defunct 20th-century technology and agriculture and see them reappraised and reborn.
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Jonny Melton knew that his club night Nag Nag Nag had reached some kind of tipping point when he peered out of the DJ booth and spotted Cilla Black on the dancefloor. “I think that’s the only time I got really excited,” he laughs. “I was playing the Tobi Neumann remix of Khia’s My Neck, My Back, too – ‘my neck, my back, lick my pussy and my crack’ – and there was Cilla, grooving on down. You know, it’s not Bobby Gillespie or Gwen Stefani, it’s fucking Cilla Black. I’ve got no idea how she ended up there, but I’ve heard since that she was apparently a bit of a party animal.”
It seems fair to say that a visit from Our Cilla was not what Melton expected when he started Nag Nag Nag in London in 2002. A former member of 80s goth band Specimen who DJed under the name Jonny Slut, he’d been inspired by a fresh wave of electronic music synchronously appearing in different locations around the world. Germany had feminist collective Chicks on Speed and DJ Hell with his groundbreaking label International DeeJay Gigolos. France produced Miss Kittin and The Hacker, Vitalic and Electrosexual. Britain spawned icy electro-pop quartet Ladytron and noisy, sex-obsessed trio Add N To (X). Canada spawned Tiga and Merrill Nisker, who abandoned the alt-rock sound of her debut album Fancypants Hoodlum and, with the aid of a Roland MC-505 “groovebox”, reinvented herself as Peaches. New York had performance art inspired duo Fischerspooner and a collection of artists centred around DJ and producer Larry Tee, who gave the sound a name: electroclash.
The lyrics tended to be witty, occasionally foul-mouthed and very camp. The sound had house music, techno, 80s synth-pop and electro in its DNA, but boasted a rough-hewn, punky edge, the latter partly down to attitude and partly down to the era’s technological advances. “It isn’t like today, where you can take an idea to a playable version in five hours on a laptop,” says Larry Tee, “but you could record something releasable in your bedroom, you could get a Juno 106 [synthesizer] and alter the sounds and fry and burn them. I’m convinced the best electroclash tracks happened because people made mistakes, the levels were too loud or there was something wrong.”
Sweat and sparkle … Casey Spooner of Fischerspooner. Photograph: John Sciulli/Getty Images
It was audibly a reaction to something. In Britain, it felt a world apart from the increasingly slick dance scene of superclubs and superstar DJs. In New York, Larry Tee suggests it was a shift away from “trance and tribal house”. For Peaches, who had recorded her 2000 album The Teaches of Peaches in her bedroom, “lying in bed, smoking weed, masturbating and making beats”, it was music made by “marginalised, queer people … who were fed up with a system that was telling us ‘rock music has to be by four beautiful boys down the line from the Rolling Stones, electronic music has to be completely serious like you’re doing brain surgery while turning buttons’. Where was the punk? And for me, I can’t think of another time in music history where women were so at the forefront – Chicks on Speed, Miss Kittin, Tracy + the Plastics. It’s always like, ‘This dude did this’, you know?”
Whatever it was an answer to – superclubs or rock’s traditional patriarchy – electroclash seemed to find an audience quickly. It wasn’t the only music Melton and his fellow DJs played at Nag Nag Nag – as underlined by a new 5CD box set, When the 2000s Clashed, they were equally wont to drop old punk singles, early industrial music or the Neptunes’ exploratory R&B – but electroclash was the club’s sonic backbone, and the night was an immediate success. Boosted by approving reviews first in the gay press, then the style magazines, its initial clientele – “a few old goths and some art students in their mum’s old curtains,” according to Melton – were soon joined by a succession of celebrities: Kate Moss, Alexander McQueen, Pet Shop Boys, Boy George, Björk. Perhaps inevitably, it attracted comparisons to celebrated New Romantic hangout the Blitz. “But there was no door policy, no guest list,” demurs Melton. “I didn’t want any of that exclusivity shit. It wasn’t posey at all, there was more a feeling of abandon. It was very hedonistic.”
“It was the epitome of amazingness, this incredible melting pot of every kind of character,” says Concetta Kirschner, better known as rapper Princess Superstar, who turned up at Nag Nag Nag while promoting her 2002 UK hit Bad Babysitter. The club had an immediate impact on her sound. “It gave me a shot of freedom. I felt like there were a lot of tightly defined rules in hip-hop. But after Nag Nag Nag, I felt I could experiment, be whatever I wanted, rap over dance music or crazy new rhythms.”
Great one-liners … Peaches. Photograph: Jo Hale/Getty Images
The newly electroclash-adjacent Princess Superstar had a Top 3 hit with Perfect (Exceeder), a collaboration with Dutch producer Mason, but it was the exception that proved the rule. For all the excitement and press coverage it generated, electroclash noticeably failed to produce a major crossover star, although it wasn’t for want of trying in some quarters. The Ministry of Sound’s record label famously spent vast sums signing New York duo Fischerspooner, but their debut album #1 failed to catch light. “Electroclash didn’t work in hygienic conditions,” offers Mark Wood, a DJ and Nag regular behind the new box set. “It worked in clubs that were dark, hot, grubby, full of smoke, all sorts of things going on.”
Peaches, meanwhile, went out on tour as a support to hard rock artists, including Marilyn Manson and Queens of the Stone Age: their audiences, she says, were “horrified”. “I think a lot of [electroclash artists] were offered these more traditional tours and thought ‘I can’t handle it’. On the Marilyn Manson tour I was spat on every night, but I rapidly developed some prank skills and some great one-liners.”
But in Britain at least, electroclash entered the mainstream regardless, audibly impacting on the way existing pop stars sounded. Sugababes rebooted their career with Freak Like Me, a Richard X-produced reimagining of the old Adina Howard hit backed by the music from Tubeway Army’s Are Friends Electric? Another Richard X mashup, Being Nobody, which melded Rufus and Chaka Khan’s Ain’t Nobody with the Human League’s Being Boiled, was a Top 3 hit for Popstars runners-up Liberty X. You could hear echoes of electroclash in Goldfrapp’s platinum-selling 2003 album Black Cherry, Rachel Stevens’ 2004 hit Some Girls and Madonna’s 2005 album Confessions on a Dance Floor. Even Fischerspooner ended up on Top of the Pops, in the company of Kylie Minogue, performing their remix of Come Into My World.
In America, however, the movement provoked a backlash. “It was unfairly beaten up after three or four years,” says Larry Tee. “Electroclash was girls, gays and theys, the music industry didn’t really invest in those three categories, and I think they were as anxious to kill it as they were disco. I think the reason they wanted to burn electroclash so fast is that it didn’t really include that soccer bro culture, which EDM did.”
Nag Nag Nag eventually closed its doors in 2008 – the club that hosted it, Ghetto, was demolished to make way for the Crossrail development. It seemed symbolic of the end of something bigger than electroclash. “It was Soho’s last stand as a grubby nightclub place – that’s all literally gone, everything moved east,” says Wood. “It was around the same time that smartphones arrived, which changed everything too. All that happened around the same time electroclash was being put to bed. Nothing lasts for ever if it’s worth having in pop music.”
But recently, Jonny Melton noticed something odd. He was being sent new dance tracks that self-described as electroclash, while club nights, including London’s Shackled By Lust and Bloghouse, also use the term to describe what’s on offer. “That would never have happened before,” he laughs. “At the time electroclash was like goth – no one who was in a goth a band would ever admit to being a goth band.”
Meanwhile, in 2023, Peaches embarked on a tour performing her debut album: it was both rapturously received and attracted an audience noticeably big on twentysomethings too young to remember its release. Princess Superstar, whose “career sort of died” in the 2010s, has watched with baffled delight as her electroclash-era hits unexpectedly enjoyed a new lease of life. First, Perfect (Exceeder) belatedly went gold in the US after it was used on the soundtrack of the 2023 movie Saltburn. Then, last year, her 2008 collaboration with Larry Tee, Licky, unexpectedly went viral on TikTok. “I think they thought it was by Britney Spears,” she says. “So I put a video up like, ‘Hey dudes’ and it all went crazy.”
She’s currently making new music, some of it in collaboration with Frost Children, a US duo among a wave of younger artists who bear the influence of electroclash: you can hear its strains in Snow Strippers, Confidence Man and the Dare. Larry Tee, who’s currently planning an electroclash documentary, suggests there’s an influence in the music of both Lady Gaga and Charli xcx’s Brat.
The music on When the 2000s Clashed still sounds remarkably fresh. Perhaps that fact that most of it remained underground, never dominating the singles chart or the radio playlists helped; so too does the fact that it’s informed by a lot of ideas that were subsequently mainstreamed: it was gender fluid before anyone talked about gender fluidity, sex-positive before anyone used that term either. “I think the younger generation get it,” nods Larry Tee, “because it was like the resistance: we’ve had enough of homophobia, enough of misogyny. For a moment, the door was open.”
Roula Khalaf, Editor of the FT, selects her favourite stories in this weekly newsletter.
Maziar Mike Doustdar thought he would just be doing the photocopying for a few months when he first took a summer job in the mailroom at Novo Nordisk, aged 21. More than 30 years later, he is in the top job at the Danish drugmaker after his predecessor was ousted in May.
His appointment was overshadowed by Novo’s announcement of steep cuts to sales and profit forecasts on the same day. Now, he has an onerous in-tray: to stop the company falling further behind in the lucrative American obesity medicines market, to tackle the problem of cheap US copycats of its drugs Ozempic and Wegovy, and to make cuts after years of ballooning costs.
His first major move was to announce plans to cut 11 per cent of jobs — employee numbers have increased almost 75 per cent in the past five years — for an estimated saving of $1.3bn a year. The resulting restructuring charges meant a further cut to its forecast for operating profit growth.
Markets gave a cautious welcome to his plan, with shares in Novo rising 3.7 per cent on the day Doustdar announced the restructuring.
Grégoire Biollaz, a senior investment manager at Novo shareholder Pictet, said it was “rational and well explained, rather than just a pure cost-cutting exercise simply to support the margins”.
Evan Seigerman, an analyst at BMO Capital Markets, said: “We applaud this bold restructuring.” But he added: “Still this is one step, we need to ultimately see concrete results.” Novo’s shares are still down more than 60 per cent in the past year.
Michael Novod, an analyst at Nordea Equities, said Doustdar was in a position to know how to reallocate money to spur growth. “When you hire 30,000 people in three and a half years, there may be a way forward to say OK, in certain areas we have too much fat, and reinvest it into more commercial operations.”
The choice of Doustdar surprised some investors, who had hoped Novo would bring in an outsider and someone with more experience in the crucial American market. Doustdar had been running commercial operations in all Novo’s markets outside the US.
Emily Field, an analyst at Barclays, said the choice was a “huge disappointment”. “The thing people wanted the most was somebody with US commercial experience, particularly on the consumer side.”
Despite an early lead, Novo Nordisk has lost market share to rival Eli Lilly’s Zepbound and Mounjaro in the US, which was quicker to launch sales directly to consumers. Lilly also has a more promising obesity drug pipeline.
Biollaz said an internal candidate would have been welcome a few years ago. “But if you fast forward, the company has struggled. It is a bit behind in the pipeline versus Lilly, [and has] issues with its cost base. I know his track record is positive. But you could see the reason for an external CEO.”
But others think the board has made the right decision. Sébastien Malafosse, co-manager of a $400mn healthcare fund at Edmond de Rothschild, said he had sold down his position in Novo as the stock soared but has bought back in at the new, much lower valuation.
“The change of the CEO acknowledges that [Novo] had some problems to address. I like the fact that they wanted some sense of continuity. That they’re not completely lost,” he said.
The US market would be Doustdar’s biggest challenge, he added, saying it was “probably where Novo has the most to gain”.
“Novo underestimated the lifestyle opportunity in the market.”
One person close to Novo’s decision-making process said that knowing the organisation well would be a huge advantage in trying to overhaul it. They added that choosing an insider also allowed the restructuring to start quickly, avoiding the months of waiting an external candidate could have required.
While Doustdar does not have US experience, he was a “100 per cent commercial animal”, the person said. He has spent his entire career in sales, unlike predecessor Lars Fruergaard Jørgensen, who started as a health economist and led corporate development and technology before taking over as chief executive in 2017.
“The big issue today is obviously existing competition and future competition, so we really need someone with commercial nous and his background is very much that,” they added.
Novod said Doustdar had a more commercial mindset than his predecessor, having been in a sales role for “more or less his entire life”.
“Securing a growth rebound in the US is a huge priority for him and the US leadership team,” he added. But he also thinks it is important for Novo to build on the strong growth it has already achieved in “massively underpenetrated” international markets.
Field said that one “silver lining” could be that Doustdar had experience in many markets where patients primarily pay cash. In the US and Europe, patients have traditionally relied on healthcare systems or insurers for their medication. With obesity drugs, people are increasingly prepared to buy direct and pay from their own pockets.
In a video posted on the day of his appointment, Doustdar said Novo Nordisk needed to throw out “yesterday’s game plan”.
“No one wants to finish the race second,” he said.
Amid the hustle of midtown Manhattan on Wednesday 11 May 2022, James Cromwell walked into Starbucks, glued his hand to a counter and complained about the surcharges on vegan milks. “When will you stop raking in huge profits while customers, animals and the environment suffer?” Cromwell boomed as fellow activists streamed the protest online.
But the insouciant patrons of Starbucks paid little heed. Perhaps they didn’t realise they were in the company of the tallest person ever nominated for an acting Oscar, deliverer of one of the best speeches in Succession, and the only actor to utter the words “star trek” in a Star Trek production. Police arrived to shut down the store.
“No one listened to me,” Cromwell muses three years later. “They would come in, hear me at the top of my lungs talking about what they were doing with these non-dairy creamers, and then they would go around to the far corner, get their order in and stand there looking at their cellphones. ‘It’s the end of the world, folks! It’s going to end! We have 15 minutes!’”
Undeterred, Cromwell remains one of Hollywood’s greatest actor-activists – or maybe activist-actors is more accurate. He marched against the Vietnam war, supported the Black Panthers and took part in civil disobedience protests over animal rights and the climate crisis. He has lost count of how many times he has been arrested, and has even spent time in prison.
But now, at 85, he could be seen as the avatar of a disillusioned generation that marched for peace abroad and progressive goals at home, only to see, in their twilight years, Donald Trump turn back the clock on abortion and many other gains.
Cromwell certainly looks and sounds the part of an old lefty who might have a Che Guevara poster in the attic and consider Bernie Sanders to be too soft on capitalism. When the Guardian visits his home – a log cabin in the farming town of Warwick, upstate New York, where he lives with his third wife, the actor Anna Stuart – he rises from a chair at the hearth with a warm greeting and outstretched hand (it is a big hand that would have required a generous dollop of glue).
Cromwell stands at 6ft 7in tall like a great weathered oak. “Probably 10 years ago, I heard somebody smart say we’re already a fascist state,” he says. “We have turnkey fascism. The key is in the lock. All they have to do is the one thing to turn it and open Pandora’s box. Out will come every exception, every loophole that the Congress has written so assiduously into their legislation.”
Cromwell has seen this movie before. His father John Cromwell, a renowned Hollywood director and actor, was blacklisted during the McCarthy era of anti-communist witch-hunts merely for making comments at a party praising aspects of the Russian theatre system for nurturing young talent and contrasting it with the “used up” culture of Hollywood.
This seemingly innocuous observation, coupled with his presidency of the “Hollywood Democrats” which later “moved slightly to the left”, led to John Cromwell being called to testify to the House Committee on Un-American Activities. He had nothing substantive to say but a committee emissary still demanded an apology.
John Cromwell refused and, with a $1m cheque from Howard Hughes for an unrealised project, moved to New York, where he acted in a play with Henry Fonda and won a Tony award. James reflects: “My father was not touched except for the fact that his best friends – a lot of them – cut him out and wouldn’t talk to him because he had been called to testify. They didn’t care whether the person was guilty or not – sort of like today.”
Cromwell’s mother, Kay Johnson, and his stepmother, Ruth Nelson, were also successful actors. Despite this deep lineage, he was initially reluctant to follow in their footsteps. “I resisted for as long as possible. I was going to be a mechanical engineer.”
Cromwell at home in his log cabin in Warwick, NY. Photograph: Bryan Derballa/The Guardian
However, a visit to Sweden, where his father was making a picture with Ingmar Bergman’s crew, proved to be a turning point. “They were creating something and my father was engaged and was working things out. It was very heady stuff for me. I said: ‘Oh, I gotta do this.’”
Art and politics collided again when he joined a theatre company founded by Black actors, and toured Samuel Beckett’s play Waiting for Godot for predominantly African American audiences in Mississippi, Alabama, Tennessee and Georgia. Some performances took place under armed guard in case white supremacists tried to firebomb the theatre.
Godot struck a chord. At one performance in Indianola, Mississippi, the civil rights activist Fannie Lou Hamer urged the audience: “I want you to pay attention to this, because we’re not like these two men. We’re not waiting for anything. Nobody’s giving us anything – we’re taking what we need!”
Cromwell says: “I didn’t know anything about the deep south. I went down and the rooming house had a sign on the outside, ‘Coloreds only’. I thought: ‘That’s a historical marker, obviously, back from the civil war.’ A wonderful Black lady took us to our rooms.
“We went out to have dinner, and the owner of the restaurant came over and said: ‘You’ll have to leave.’ I’d never been thrown out of a restaurant before, so I immediately stood up with my fist balled. I would have done something stupid. John O’Neal [one of the company’s founders] informed the man that he was violating our civil rights and that they would get to the bottom of it.”
But then, mid-anecdote, Cromwell stops himself and breaks the fourth wall of our interview. “I’m listening to myself,” he says. “These are not just stories about an actor doing his thing growing up, trying to get the girl, trying to keep his nose clean, trying not to get hurt. People were dying, people were being beaten, people were being shot, people had crosses burned on their lawns.
“I feel strange recounting it always with the points that I think an interviewer would be interested in: ‘My story’. People ask if I should write a book because I have all these stories and I’ve done a lot of different things as well as acting.”
Later, his wife will confide that she is among those lobbying Cromwell to write a memoir. But he has little appetite for such a project, he insists, since he fears it would be formulaic and “because my father tried it and it was so bad even his wife, who adored him, said: ‘That’s really stinky, John.’”
We push on with his story all the same. Cromwell had been notching up film and TV roles for decades when, at the age of 55, his career took off thanks to his role as a farmer in Babe, a 1995 film about a pig that yearns to be a sheepdog. It was a surprise hit, grossing more than $250m worldwide.
Cromwell with the eponymous Babe in 1995. Photograph: Universal/Everett/Shutterstock
Cromwell funded his own campaign for an Oscar for best supporting actor in Babe, spending $60,000 to hire a publicist and buy trade press ads to promote his performance after the studio declined to fund it. The gamble paid off when he received the nomination, the kind of accolade that means an actor is offered scripts rather than having to trudge through auditions.
“I wouldn’t be here if I had not gotten a nomination,” he says, “because I was so sick of the dance that had to be done when you did an audition. I finally asked a director: ‘What was it about the audition that made you give me the part? I did it no differently than I’ve done anything.’ He said: ‘Jamie, it has nothing to do with your performance; we just want to see that you’re the kind of guy we want to spend four weeks with.’
“It was the chip on my shoulder which, because I knew him, didn’t show as much as it did when I went in to audition with a stranger who I identified as my father. I had the thing from my father – there he is again in me, telling me I’m not good enough, I’ll fail in the reading. I was just fucking sick of it.”
With Helen Mirren in The Queen. Photograph: Cinematic/Alamy
The recognition for Babe led to roles including presidents, popes and Prince Philip in Stephen Frears’ The Queen, as the industry tried to categorise him. In Star Trek: First Contact he played the spacefaring pioneer Dr Zefram Cochrane, who observes of the Starship Enterprise crew: “And you people, you’re all astronauts on … some kind of star trek.”
Cromwell views Hollywood as a “seamy” business driven by “greed” and “the bottom line”. He criticises the focus on “asses in the seats”, the lack of genuine debate on issues such as racial diversity and the increasing influence of online followings on casting decisions. He has “no interest in the parties” and sees the “game” as secondary to “the deal”. He also admits that he can be a handful on set: “I do a lot of arguing. I do too much yelling.”
He offers the example of LA Confidential, which he describes as a “genius piece of work”. In one scene, Cromwell’s menacing Captain Dudley Smith asks Kevin Spacey’s Jack Vincennes, “Have you a valediction, boyo?” before shooting him dead. Spacey, by then an Oscar winner, disagreed with director and co-writer Curtis Hanson over what Vincennes should reply. A quietly defiant Spacey won their battle of wills.
This spurred Cromwell to try a line change of his own. Hanson objected. “Sure enough, he stands behind me and says: ‘Jamie, I want you to say the line the way it was written.’ But not having Kevin’s experience and his propensities, I said: ‘You motherfucker, fuck you, you piece of shit! You don’t know what the fuck you’re doing.’ I kicked dirt on him. I punched a camera car.
“He had his arms crossed and he looked at me and said: ‘You asshole, I’m going to cut it out in post [production] anyway – it’s not going to be in there and you’ll never work in this town again.’ I learned: ‘Oh shit, you’d better perfect this technique because they’re not necessarily going to like this.’”
‘A genius piece of work’ … Cromwell with Russell Crowe in LA Confidential. Photograph: Cinematic/Alamy
Thirty years on, of course, it is Spacey who has been banished to the Hollywood wilderness over sexual misconduct allegations, though he was not convicted of any crimes. Actors such as Stephen Fry, Liam Neeson and Sharon Stone have argued that Spacey paid the price and that unproven allegations should not permanently end his career.
Asked for his take, Cromwell at first demurs. “No, I can’t do that, man,” he protests. “I can’t talk about a fellow actor.”
But then he brings up the late financier Jeffrey Epstein, suggesting that the convicted sex offender’s elite social circle has received more lenient treatment than Spacey. “They have one set of rules for them and another set of rules for Kevin. Kevin gets whacked, it means the end of his career. They [the Epstein associates] all fly down there on their Lolita Express, they do whatever they want. What happens to them? Zilch happens to them. The justice department is turned upside down. That’s what pisses me off. The duplicity of it. It’s disgusting.”
In a varied TV career, Cromwell has won an Emmy award for American Horror Story: Asylum and earned Emmy nominations for roles in RKO 281, ER, Six Feet Under and most recently Succession where he played Ewan Roy, the estranged brother of the Rupert Murdoch-style patriarch Logan Roy (Brian Cox).
Cromwell spent an hour talking with Jesse Armstrong, creator of Succession, before agreeing to take on the role, insisting that Ewan Roy’s break from the family should be based on political morality rather than financial jealousy. “I figured out he was a Vietnam veteran. He went in for two tours. I said: ‘Nobody comes back from two tours in Vietnam unblemished, untouched by the havoc, the chaos of that place.’”
Cromwell adds, however, that Armstrong is a “smart” writer who managed to write around his objections and get him to play the character that Armstrong wanted. The arc culminated in a powerhouse eulogy delivered by Ewan at Logan’s funeral – a perfect marriage of the crafts of acting and writing.
Ewan’s formative experience in Vietnam was an inversion of Cromwell’s own political awakening as an anti-war protester. He was arrested for the first time at a huge demonstration in Washington in 1971. He recalls: “I took a swing at a cop because he hit this woman right in front of me, across the face with his baton, smashing her glasses, and I said: ‘That can’t be.’
“I grabbed him and came away with his baton, and then they all jumped on me, but nobody hurt me. As I was being loaded into a van, the cop I jumped came at me with his fist, he threw it and it glanced off me, and then they shut the door and nothing happened to me.”
‘I do too much yelling on set’ … Cromwell in Succession with Brian Cox, right. Photograph: HBO
There have been dozens of arrests since then. After a sit-in protest in 2015 at a natural-gas-fired power plant in Wawayanda, New York, Cromwell refused to pay a $375 fine and ended up in prison. “The guy who did the interview didn’t know who the fuck I was and said: ‘Are you afraid you’ll be raped when you’re in here?’ I said: ‘Not unless they’re a lot hornier than I think they are,’ because it didn’t make any sense.
“He said: ‘Are you afraid that you’ll rape someone?’ Will I catch the disease of the class system in prison in order to protect myself and put myself in a position of finding some defenceless young men sent in there for some reason, and get a couple of guys to hold him down while I fuck him? That’s the thinking.”
Cromwell describes his three days inside as “moving”. He went on hunger strike and had the poignant experience of seeing “Oh God, get me out of here” written in the grout by another inmate. Soon after, he was arrested again, this time for disrupting an orca show at SeaWorld.
He is a vegan and an honorary director of People for the Ethical Treatment of Animals (Peta), which he calls “the most ethical organisation I have ever been involved with”. He insists that society must “stop killing animals, start creating vegan foods, which are nutritious, tasteful and don’t involve killing another animal”. He sees animal agriculture as a significant contributor to global heating, which “is going to kill us. It’s going to kill our children. It’s going to kill the planet”.
Cromwell leads a Peta protest against Air France’s Cruelty To Monkeys in 2014. Photograph: Joe Kohen/FilmMagic
Cromwell got the Starbucks glue idea from Extinction Rebellion, the British-founded movement that aims to compel government action through non-violent civil disobedience. Extinction Rebellion’s road blockades, and the group Just Stop Oil’s attacks on artworks, have been criticised by some as counterproductive. He disagrees.
“If you don’t push back, they eat you alive,” he insists. “Now, is pushing back going to go to excess? Sometimes, yes. We’ve got crazies; we have double agents, we have people infiltrated. You think the East Germans, the communists had it? They don’t have anything to put up with compared to what we’ve got going on in this country as the ratline for taking people out, misinformation, throwing elections, buying elections. Every fucking thing that they can do, they do.”
But did he ever worry that activism would hurt his acting career? “I don’t think they give a shit what – no, I take that back. Enough people know me now because of my animal activism that the studio might consider I’m a troublemaker and, when it comes to the press junket, instead of talking about the movie I’m going to talk about veganism or Gaza.
“So the best way to shut him up is just to shun him, and that’s true for Will Geer [an actor and activist blacklisted during the McCarthy era] and that’s true for a lot of people who had something to say and wanted to say it, and could have been able to say it.”
Cromwell’s ‘Dinosaur protest’, calling on world leaders to ‘Stop the Human Asteroid’ at Cop15 in Montreal, Quebec, Canada in 2022. Photograph: Graham Hughes/AP
In Cromwell’s worldview, the descent of the US into tyranny runs much deeper than one president. It is an amoral system designed to benefit oligarchs, exploit loopholes and grind down the working class and the planet. Trump is merely “the frontman”, he says.
“He’s the guy outside the theatre saying: ‘Come on in! You’re going to love this show, I got the best people.’ That’s who he is. He’s a shill for this shit. While Jeff Bezos, Elon Musk and those guys walk around, they don’t give a rat’s ass about any worker, about any environmental issue. They don’t give a shit.
Cromwell with his 2018 Audi TT at home in Warwick, NY. Photograph: Bryan Derballa/The Guardian
“The governmental system that we have, the societal system we have is so corrupt and so full of mendacious, egregious lies that it’s very hard to know how to look at it and say: ‘Well, what do I do?’”
Cromwell’s generation must have thought they had won significant battles for women’s rights, civil rights and the environment. Yet, now, in old age, they are forced to watch Trump and his allies unravel that progress. After all the years, all the protests, all the arrests, does he still have hope?
He cites students protesting at New York’s Columbia University, civilians protesting in Israel and a few American politicians who are still fighting the good fight. He also talks about his T-shirt, which is black and printed with the words “Dare to be an artist” in red.
He explains: “If celebrity is stuffed in your pocket, it burns a hole in your pocket. You have to spend celebrity so that people can learn something from it and they can hear you and you can speak for them. This is the advantage that I have that somebody in Texas does not have. You come and stick a microphone in front of me and it goes someplace and somebody listens to it.”
Starbucks, by the way, capitulated last year and announced that it will no longer charge extra for vegan milks. Cromwell was not shouting into the void after all.
Where: University of Pennsylvania, in Philadelphia
Who: Jesse Gelsinger
Twenty-six years ago today, on Sept. 17, a teenager who had received an experimental gene therapy died. His death led to needed changes in the clinical trial process while also spurring skepticism that would ultimately stall the field of gene therapy for years.
Jesse Gelsinger was an 18-year-old with ornithine transcarbamylase (OTC) deficiency, a genetic disease that affects about 1 in 40,000 newborns. The condition makes the body unable to make an enzyme that would normally break down ammonia, a natural waste product of metabolism. Without this enzyme, ammonia builds up in the body and poisons the blood.
About 90% of babies with the most severe form of OTC deficiency die. But Gelsinger — who had a milder, “late-onset” form of the disease — had reached adulthood by strictly adhering to a low-protein diet and a regimen of 50 pills a day, to help reduce the amount of ammonia in his blood and offset its effects. Although Gelsinger was small for his age and experienced a dangerous ammonia crisis when he stopped taking his pills, he was otherwise healthy.
Gelsinger wanted to help newborns with the disease, so he enrolled in a trial to test the safety of a gene therapy aimed at correcting the defective OTC gene. The treatment used a weakened form of an adenovirus, a type of cold virus, to deliver the corrected form of the OTC gene into Gelsinger’s cells.
Gelsinger flew to the University of Pennsylvania, where the trial was being run, and had the treatment infused into the artery feeding the liver on Sept. 13, 1999. He had flu-like symptoms that day, as was expected. But by the next day, he was jaundiced, he developed a severe inflammatory reaction and a blood clotting disorder, and his organs began to fail. He was taken off life support around 2:30 p.m. on Sept. 17. Investigations revealed that his death was caused by a severe immune reaction to the virus used to deliver the treatment.
A Food and Drug Administration (FDA) investigation found numerous problems with Gelsinger’s enrollment in the trial, according to The New York Times. First, his liver function was too poor and ammonia levels were too high when he started the trial. Second, the team did not disclose to patients that, prior to the trial, lab animals had died from higher doses of the therapy. Additionally, other human participants had experienced serious side effects. Meanwhile, Dr. James Wilson, the lead investigator, owned stock in Genovo, the company developing the therapy, and stood to gain millions if the therapy was successful.
James Wilson was the lead investigator for the OTC gene therapy trial. That trial, along with other gene therapy trials at the University of Pennsylvania, were halted after Gelsinger’s death. Wilson continued to work in the field and has since been involved in the development of several gene therapy products, including ones for spinal muscular atrophy and an inherited form of blindness. (Image credit: Anadolu via Getty Images)
“We don’t know what the impact of these deviations are,” Dr. Kathryn Zoon, then-director of the FDA’s Center for Biologics Evaluation and Research, said at the time, The New York Times reported. “But they’re important.”
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Gelsinger’s father, Paul Gelsinger, launched a wrongful-death suit against parties involved in the trial; it was eventually settled for an undisclosed sum.
Gelsinger’s death led to several changes in how gene therapy clinical trials are run and to stronger informed-consent requirements. All of the gene therapy trials underway at the University of Pennsylvania were halted. The FDA also started requiring greater monitoring for gene therapy trials.
The death cast a pall over the field, and as public and private funding for the approach dried up, gene therapy stalled. Eventually, however, with progress in understanding the viral vectors used to deliver gene therapy, and later, with the advent of the cut-and-paste gene editing tool CRISPR, the field has rebounded.
Scientists have now used gene therapy to treat many rare genetic disorders, including severe combined immune deficiency and multiple forms of blindness. The first CRISPR-based gene therapy, which treats sickle cell anemia by disabling a specific gene, was approved in January 2024. And in 2025, scientists announced that they’d used a customized CRISPR treatment designed for his particular gene mutation to treat a baby with a rare and devastating genetic syndrome.
Right now, the number of approved gene therapy products is still small. Many of those approved therapies use cells that are edited in the lab and then returned to the body to fight or treat cancer, rather than changing the genes in the nucleus of a patient’s own cells.
But the field has come a long way since Gelsinger’s death, and in 2021, scientists used gene therapy to successfully treat OTC deficiency.