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  • Emergency Colectomy for Obstruction in Microsatellite Instability Colonic Cancer: A Complete Response Following Neoadjuvant Immunotherapy

    Emergency Colectomy for Obstruction in Microsatellite Instability Colonic Cancer: A Complete Response Following Neoadjuvant Immunotherapy


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  • ‘Big Cloud’ is Building Power via Pervasive Investments

    ‘Big Cloud’ is Building Power via Pervasive Investments

    Nadia Piet + AIxDESIGN & Archival Images of AI / Better Images of AI / Cloud Computing / CC-BY 4.0

    Criticism of Big Tech monopoly power from journalists, regulators, and scholars often focuses on the largest mergers and the highest-profile anticompetitive practices. The remedies trial in the Google Search antitrust case is a good example, as is Microsoft’s much-criticized acquisition of Activision Blizzard, or the monopoly case Meta is embroiled in. Critiques are particularly pointed against the monopoly power held by the subset of Big Tech firms which are the large cloud infrastructure providers. Just three companies comprise which “Big Cloud” — Microsoft, Amazon, and Google — control two thirds of the cloud computing market, thereby controlling services that millions of businesses and governments across the globe rely on. Big Cloud has come under fire for anticompetitive practices across the globe, and most relevant to our focus here, Microsoft faced particular scrutiny for its eye popping $14 billion investment in OpenAI.

    But while $14 billion investments grab headlines, our new report shines light on a distributed, far less visible, and cumulative form of dependence garnered via investment. We analyze investment database Crunchbase, which collates records of investment from a variety of sources, and find that Big Cloud invests in over a hundred times more deals than other Big Tech companies in the “Magnificent Seven” (Apple, Meta, Tesla, and Nvidia). Moreover, Big Cloud has participated in a staggering $250 billion in total funding dispersed throughout the startup ecosystem. Our research suggests these investments comprise a massive, strategic effort to bend the technology ecosystem towards Big Cloud’s interests.

    Big Cloud invests much more often than other important investors. Source.

    As shown in the graph above, the scale of Big Cloud’s investments are very much unlike other Big Tech company investments, and similar in scale to startup accelerators and venture capital investors. But traditional startup accelerators make many small deals to early-stage startups, spreading money out in search of rare thousand-fold returns, while providing mentorship and connections. Traditional VCs make larger, but fewer, deals than accelerators, and are often focused on repeated deals in ever-larger rounds. Both are focused on making, above all, a huge payoff. But as we explore in the report, Big Cloud makes both large deals and many deals.

    Big Cloud invests in pursuit of industry capture

    So why does Big Cloud pursue this relatively unique investment strategy? Our analysis reveals that investments intensify other anticompetitive practices. We unpack their playbook — including accelerator programs, the pursuit of sole or lead investor roles, and the pursuit of a kind of vertical integration through investment — to show how Big Cloud companies ensnare early-stage startups across the entire tech industry into their proprietary ecosystems.

    The playbook starts with each Big Cloud entity setting up accelerator programs, which are special funding vehicles that operate with cohorts of investment targets, typically prefer very early-stage startups, and provide them not only capital but also networking, office space, and — critically — compute credits. We found that Google, Microsoft, and Amazon each have strong affinities for investments through accelerators, with 52.9%, 59.7%, and 25.6% of their investments, respectively, issued through accelerator programs. In contrast, the other Big Tech companies we studied do not run accelerator programs at anywhere close to the same scale, or even at all.

    Startups receiving investment are especially at risk of heavy financial dependence on their Big Cloud partner as their sole or lead investor. Big Cloud companies act as the sole investor for 53 to 57 percent of deals they participate in, and lead investor for 66 to 70 percent of deals. Other Big Tech companies aren’t as concerned with playing as significant of a role in each of their deals, and are the sole investor on an average of just 34 percent of investments and lead investor on 44 percent of investments. That significant influence exerted by Big Cloud investors, in tandem with other anticompetitive strategies like high egress fees and minimum spend contracts, locks startups receiving investment into Big Cloud’s ecosystems.

    Cloud computing giants use these investments to exert influence over the entire tech industry, and especially over emerging (but yet unproven) technologies like AI. As our research shows, Big Cloud’s investments reach across the AI supply chain — into data providers, infrastructure layers, developer tooling, and application companies — acting as a form of “soft” vertical integration that escapes the kind of scrutiny more often directed towards vertically integrative acquisitions. Stipulations as part of investments reinforce Big Cloud’s AI edge: participation in some of Google’s accelerator programs requires an “AI-first” approach in addition to using Google Cloud Platforms. Amazon’s incentive structure multiplies for generative AI startups — offering $300,000 in credits for AI companies, three times as many credits as other kinds of startups, to steer them towards compute-heavy business strategies that are especially lucrative for the Big Cloud investor.

    Big Cloud investment targets the global economy

    The scale for this playbook is global. Our research finds that Big Cloud invests abroad at a pace and preference far outpacing Big Tech competitors. Big Cloud makes just over half of its investments abroad, with Google, Microsoft, and Amazon making 1,645, 1,001, and 322 investments abroad respectively. In contrast, Apple, Nvidia, Tesla, and Meta together only have made 80 investments abroad to date — any one of the Big Cloud companies easily invests more abroad than the next four tech giants combined.

    Big Cloud invests abroad to seed influence in newer markets. Accelerator programs are particularly useful for this strategy, with Google making 79.5% of its non-US investments through accelerator programs, compared to just 26.8% of its US investments. Microsoft and Amazon follow similar trends. In domestic markets, Big Cloud’s influence already reaches a broad audience. Abroad, Big Cloud uses accelerators as instruments of soft control — expanding its footprint under the guise of startup support while locking in infrastructure dependence.

    For recipient states, this translates to a slow erosion of digital sovereignty as national innovation systems are quietly tethered to the US-based cloud infrastructure, billing relationships, and technical roadmaps. As Big Cloud’s anticompetitive practices now appear to have full backing of the US government, our findings emphasize the importance of responses from both the Global South and the Global North in combating encroachment on digital sovereignty via investment. We join the broad chorus of voices advocating for digital sovereignty to prevent against US dominance, and especially encourage a broad approach to the sovereignty-focused frameworks to also include the financial infrastructure the AI supply chain may be built on. Any kind of “sovereign” AI with the independence that sovereignty frameworks call for can’t be built on US infrastructure backed by Big Cloud’s dollars.

    Conclusion: acting against cloud investment capture

    More broadly, our results emphasize the importance of structural separation, echoing many past calls. Dependence on Big Cloud is not just technical or infrastructural: it is also financial, as a source of investment. This then compounds the need for structural separation: Amazon, Google, and Microsoft must be compelled to split their cloud business from their other businesses that run on the cloud, so that they do not both provide infrastructure and compete with the customers and investees relying on that infrastructure.

    Most importantly, instead of just scrutinizing the biggest deals, researchers and regulators must contend with the cumulative nature of these investments — as we have shown here. It is the industry-wide effect of thousands of deals, rather than any single investment, that allows Big Cloud to grow even bigger, constitutes a chokehold over national economies, and constrains the technological choices available to millions of people. Any one of these investments may be small and insignificant, but they cumulatively shape the startup and developer ecosystem in Big Cloud companies’ interest. As we scrutinize Big Cloud’s investments, we risk missing the forest for its tallest trees.

    The full report, “How Big Cloud becomes Bigger: Scrutinizing Google, Microsoft, and Amazon’s investments, can be accessed here.

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  • Iran says direct nuclear talks with US possible under suitable conditions, ISNA reports – Al Arabiya English

    1. Iran says direct nuclear talks with US possible under suitable conditions, ISNA reports  Al Arabiya English
    2. Pezeshkian’s defense of diplomacy, fealty to Khamenei muddies waters in Iran  Amwaj.media
    3. Iran’s President Says Rebuilding Nuclear Sites Futile Without Talks With Washington  Radio Free Europe/Radio Liberty
    4. IRGC Official Criticizes Iranian President’s Public Statements  IranWire
    5. Unequal battle for Pezeshkian over Zangezur  Aze.Media

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  • DLA Piper advises Ragnarok in its acquisition by CASE

    DLA Piper advised Ragnarok Technologies (Ragnarok) in its acquisition by CASE, a portfolio company of private equity fund AE Industrial Partners and a provider of high-end software development and cloud engineering services.

    Ragnarok is a leading provider of advanced IT solutions to the US government, as well as commercial enterprises. Ragnarok offers services in systems engineering, software development, cybersecurity, and program management.

    “The decision to sell our business marked a pivotal milestone. From day one, DLA Piper demonstrated unparalleled market insight and innovative problem-solving, always keeping our goals front and center. Their adeptness at managing challenges, providing clear and actionable guidance, and assuming much of the transactional workload allowed us to remain focused on advancing our mission. What truly distinguished DLA Piper was their genuinely collaborative approach – they didn’t just advise us; they were focused on helping us achieve long-term success, ultimately delivering a result that exceeded all expectations,” said Ethan Grambow, CEO and Co-Founder of Ragnarok.

    “We are honored to have advised Ragnarok on this landmark transaction,” said Jeffrey Houle, Co-Chair of DLA Piper’s Aerospace, Defense, and Government Services Transactional practice. “Collaborating with such an innovative and mission-driven organization was a privilege, and we are excited to see Ragnarok continue to thrive in this next chapter of its journey.”

    Along with Houle (Washington, DC), the DLA Piper team included Partners Julia Kovacs (Washington, DC) and Thomas Pilkerton III and Jordan Bailowitz (both Baltimore); Of Counsel Brad Jorgensen (Austin); Senior Attorney Cara Hupprich (Northern Virginia); and Associates Traneke Hamrick (Washington, DC) and Brendan Kelly (Baltimore).

    With more than 1,000 corporate lawyers globally, DLA Piper helps clients execute complex transactions seamlessly while supporting clients across all stages of development. The firm has been rated number one in global M&A volume for 15 consecutive years, according to Mergermarket, and ranked as number one in VC, PE and M&A in combined global deal volume according to PitchBook.

    DLA Piper’s Aerospace and Defense practice offers a multidisciplinary international team with deep experience across the defense contracting lifecycle, from bid preparation and regulatory compliance to contract performance and dispute resolution. Our integrated team of government contracts specialists and corporate attorneys adeptly manage complex transactions — including mergers and acquisitions, joint ventures, and strategic partnerships — essential for success in this rigorously regulated sector. Drawing upon extensive experience with federal acquisition regulations and national security mandates, we provide comprehensive legal counsel that safeguards compliance while facilitating clients’ strategic growth within the aerospace and defense industry.

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  • Amazon Project Kuiper sends 24 more satellites into space

    Amazon Project Kuiper sends 24 more satellites into space

    Amazon has released updates surrounding Project Kuiper, the low Earth orbit satellite network. The constellation is expected to have over 3,200 satellites, the first 27 of which were deployed in April 2025.

    The latest development has seen SpaceX deploy the fourth batch of satellites on 11 August, sending 24 satellites into orbit and reaching a total of 102 spacecraft.

    Prior to this, the last mission took place on 16 July, deploying another 24 satellites using the Falcon 9 rocket.

    Photo: Amazon

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  • Windows 11 23H2 Home and Pro reach end of support in November – BleepingComputer

    1. Windows 11 23H2 Home and Pro reach end of support in November  BleepingComputer
    2. Microsoft consigns another version of Windows to the scrapheap  Daily Express
    3. Microsoft announces plans to kill off another operating system, one year after Windows 10  GB News
    4. Microsoft is ending Windows 11 version 23H2 support soon  Neowin

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  • Commonly used medications pose increased risk of memory problems, study finds

    Commonly used medications pose increased risk of memory problems, study finds



    Commonly used medications pose increased risk of memory problems, study finds 

    A new study conducted by the University of California, San Diego, unveiled that commonly prescribed anticholinergic drugs may increase the risks of mild cognitive impairment (MCI).

    Cognitive impairment is an umbrella term used to describe the decline in an individual’s ability to think, learn, remember, reason and solve problems. 

    MCI is a specific type of cognitive impairment characterized by a noticeable decline in a person’s thinking abilities. It is potentially considered as an early sign of dementia.

    The study analyzed 688 older adults of an average age of 74 years no initial cognitive issues.

    It was observed that those who took anticholinergic medications were 47% more likely to develop memory problems over a decade.

    These medicines are prescribed for conditions such as high blood pressure, allergies, and depression.

    The major findings of the study are:

    • The participants with brain markers associated with Alzheimer’s were four times more vulnerable to cognitive decline after taking these drugs.
    • Those having a genetic vulnerability to Alzheimer’s had 2.5 times higher odds of impairment.
    • Medicines like blood pressure drugs (metoprolol, atenolol), allergy medications (loratadine), and antidepressants (bupropion) highly contribute to developing cognitive impairment.

    These drugs typically inhibit the release of acetylcholine, a neurotransmitter critical for memory and learning.

    While they are effective for their intended uses, long-term usage raises cognitive concerns.

    To combat this, the study recommends exercising regularly, eating antioxidant-rich diets, and consuming certain fruits that may help to slow cognitive decline.

    The study adds to growing evidence that some medications while being advantageous for one condition may inadvertently impact brain health highlighting the need for personalized medical care. 

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  • Apple’s improved Siri voice assistant may finally have a release date – and I’m ready to ditch Gemini for it

    Apple’s improved Siri voice assistant may finally have a release date – and I’m ready to ditch Gemini for it

    Kerry Wan/ZDNET

    ZDNET’s key takeaways:

    • An upgraded version of App Intents could make Siri the true hands-free iPhone companion.
    • Apple is currently testing these Siri App Intents with a handful of third-party apps.
    • The revamped Siri could ship in the spring of 2026, reports Bloomberg.

    When Apple first announced an upgraded and more capable Siri, every one of its users was reasonably excited. Unfortunately, that promise never happened, and the new Siri continues to be delayed. However, ahead of the upcoming Apple event, new details have emerged that may make antsy users a little more patient. 

    And if the rumors are true, I’m anticipating the big Siri rollout to finally get me to switch from Gemini to Apple’s voice assistant.

    Also: This iOS 26 update ruined the iPhone camera app for me – then Apple saved the day

    According to a report from Bloomberg’s Mark Gurman, App Intents could “finally make Siri the true hands-free controller of your iPhone.” He explains, “App Intents will mean: With nothing but your voice, you’ll be able to tell Siri to find a specific photo, edit it, and send it off. Or comment on an Instagram post…. Siri could operate your apps like you would — with precision, inside their own interfaces.”

    Why this upgrade matters so much

    All of this still sounds like a far-fetched dream, especially when other companies are struggling to publicly roll out similar capabilities to their voice assistants. Amazon announced Alexa+ in February and showcased demos of it booking an Uber and a concert ticket, but Alexa+ is yet to get wider public availability. 

    It’s because it is hard to get high-stakes tasks related to health or banking apps correct every time. Gurman reports that Apple engineers have been struggling to ensure that revamped Siri is “accurate enough to handle high-stakes scenarios.”

    Also: 5 iOS 26 features that made updating my iPhone worthwhile (and how to try them)

    Per the report, Apple is currently testing these Siri App Intents with a handful of third-party apps, like YouTube, Amazon, Facebook, WhatsApp, Temu, Threads, and more. However, it could “sharply limit what Siri can do” in other sensitive categories and even exclude those areas altogether. 

    A new and updated voice assistant isn’t just about making Siri smarter but enabling a new, voice-first interface across the Apple ecosystem. As of now, Gemini Live has been the most capable voice assistant on a phone, from those that I have tested. 

    Samsung Galaxy Z Flip 7 Gemini

    Sabrina Ortiz/ZDNET

    I’m currently using the Galaxy Z Flip 7 and find myself conversing with Gemini Live frequently, but there’s friction when it comes to app compatibility. I wish I could add ideas to my working Google Doc or reschedule meetings and Calendar invites just by asking my phone, but that’s not possible yet.

    Google is expanding Gemini Live support to several in-house productivity apps, which should improve the experience — I can now add my thoughts to Google Keep and add reminders to Google Calendar, which is far more capable than the current version of Siri.

    Also: I changed these 6 settings on my iPad to significantly improve its battery life

    But if Apple succeeds in building the Siri that’s being speculated about, I would gladly switch to using it instead of Google’s Gemini.

    I love it when I am out and about and my Meta Ray-Bans announce a WhatsApp notification, and let me reply to that person or call them without touching my phone. I see a future where I won’t have to touch a screen to interact with my gadget, but will be able to talk to it through my smartglasses or a pair of earbuds. 

    While this idea sounds fun and futuristic, it’ll have higher risks and little margin of error, which is why it hasn’t happened yet. As Gurman says, if Apple is actually able to bring it to market, “it could potentially be a hit that many users didn’t see coming.”

    Get the morning’s top stories in your inbox each day with our Tech Today newsletter.


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  • SA U18 make it two from two against Ireland

    SA U18 make it two from two against Ireland

    Playing against a light wind in the first half, the South Africans protected the ball very well and almost set up camp in the Irish half, with their strong set piece play forcing the visitors to work very hard on defence. A couple of unforced errors cost the hosts though, but they still managed to score three tries before the break.

    Ireland, who beat the SA U18 ‘A’ side by 36-33 last Friday, restored some parity in the second half, but the South Africans showed too much composure and added four more tries to their tally for a second convincing win after they beat France by 43-21 in the opening round of the series.

    Under pressure for most of the opening exchanges, Ireland conceded a string of penalties and the SA U18s finally breached the visitors’ defence in the 15th minute when Jayden Joubert (lock) drove over.

    Nine minutes later, SA hooker Clinton Agu burst away from a strong maul and beat one defender for the second try, while Jayden Brits (scrumhalf) added his name to the score sheet with a try from a quick tap penalty shortly before the break. After missing the first two, Ruben Groenewald added the conversion to give the hosts a 17-0 lead at the break.

    That changed to 24-0 straight after the restart when the South Africans pounced on an Irish mistake to send Lamla Mgedezi (wing) over in the left hand corner, with Groenewald adding the extras.

    A penalty try for a collapsed scrum against Ireland followed a few minutes later, and at 31-0, the SA U18s were firmly in control, although the visitors started to play with more confidence.

    They finally scored their first try after 47 minutes when Ireland captain and prop Harry Goslin burst over, but apart from that, the South Africans’ defence was generally strong and when Jadrian Afrikaner (replacement wing) exploited space on the left for their sixth try, the momentum swung back in the hosts’ favour.

    Ethan Adams had the final say a few minutes before the final whistle when the strong midfielder bulldozed his way over the tryline from short range, with Liyema Nela converting to make it 45-5.

    Scorers:

    SA U18 45 (17) – Tries: Jayden Joubert, Clinton Agu, Jayden Brits, Lamla Mgedezi, Jadrian Afrikaner, Ethan Adams, Penalty try. Conversions: Ruben Groenewald (2), Liyema Nela (2).

    Ireland 5 (0) – Try: Harry Goslin.

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  • World Games 2025: Watanabe Satomi and Victor Crouin claim squash titles

    World Games 2025: Watanabe Satomi and Victor Crouin claim squash titles

    Crouin claims second World Games crown

    In the men’s final, Victor Crouin defeated a spirited Balazs Farkas to retain the World Games title he first won in Birmingham three years ago.

    The 26-year-old Frenchman beat the Hungarian 11-9, 11-9, 11-5 in an attritional encounter, with Crouin’s continued efforts to generate winners eventually wearing down the No.6 seed.

    “It means the world I came here to defend the title, and I just did it, so I’m very proud of myself to win this title a second time,” Crouin told Olympics.com after.

    “I think this was the best preparation for the Olympics, coming in three years, to experience a multi-sports event like this one was very important for me to try and get some feedback on how to handle the kind of pressure that comes with multi-sports events, logistics, being part of a bigger French team.”

    He continued: “It wasn’t my best squash this week, but I found ways to win, which is very important and I think I want to keep that positive momentum going into the start of the season.”

    Farkas had presented something of a banana-skin for Crouin, having beaten No.2 seed Dimitri Steinmann in the semi-finals and not dropped a single game across the tournament.

    Crouin, meanwhile, had arrived at the title-decider off the back of an 83-minute-long epic against Colombia’s Miguel Rodríguez not 24 hours earlier.

    But no signs of fatigue on the Frenchman were to be found, with Crouin noticeably getting better as the games unfolded.

    Whereas the first two games had been dominated by long and intense rallies, the decider was much more decisive with the French ace punching ahead with a string of winners to take an 8-2 lead. And while Farkas tried, he could do little to stem the rising tide of his opponent.

    Despite the loss, the Hungarian was pleased with the outcome.

    “For me, I mean, this tournament was really important,” Farkas told Olympics.com after.

    “I was training really hard, and the whole summer I did a really good preparation. Before the Games, I was a little bit nervous because I really wanted to reach a really good result. I didn’t know if it would be a medal or not. I just tried to focus on playing every game like it would be the last, so I was really happy to reach the quarters, then after, the semi-finals, and I tried everything in the final as well, so I’m really happy right now.

    He continued: “I think he [Victor] played really well. He put me under so much pressure. We are really good friends out of the court, so we always try to play our best game.”

    In the bronze medal matches, Spain’s Marta Dominguez saw off Ho Tze Lok of Hong Kong, China, 12-10, 11-5, 11-2, while Colombian veteran Rodríguez defeated Steinmann 5-11, 11-8,11-5, 11-6.

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