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The Powerbeats Pro 2 are down to their best price yet for Prime Day

The Powerbeats Pro 2 are only a few months old, but they’re already on sale for an all-time low of around $179.95 ($70 off) at Amazon, Walmart, and Best Buy. We’ve seen the wireless earbuds drop in price here and there since launching in February, but Amazon is currently one-upping the previous low by a cool $20 for Prime Day. The earbuds aren’t quite as cheap as Apple’s second-gen AirPods Pro, which are down to $149 ($100 off) at Amazon, but if you want a pair specifically for working out, the Powerbeats Pro 2 are the ones to get.

It took beats nearly six years to release a sequel to the original Powerbeats Pro — and it was worth it. The latest model is our favorite pair of earbuds for sports and working out thanks to features like active noise cancellation, heart rate monitoring, and a handy transparency mode that pipes outsides noises in. The updated mics do a solid job of filtering out ambient noise, too, while on-ear buttons provide tactile feedback when controlling playback. They even support hands-free voice control via Siri.

What makes the Powerbeats Pro 2 stand out among other Beats and Apple earbuds, however, is that they support heart rate monitoring. Each earbud features an optical heart rate sensor and accelerometer, which is the same tech found in the Apple Watch. The collected data integrates with apps from Nike, Runna, Peloton, and others, giving you insight into your performance. If you don’t already rely on a fitness tracker to track your workouts, the Powerbeats Pro 2 are a decent alternative.

The earbuds are also more comfortable to wear over extended periods. For instance, the ear hooks are 50 percent smaller, while the buds themselves are 20 percent lighter than the original model. Heck, even the case has shrunk by 33 percent. Despite their smaller size, though, the Powerbeats Pro 2 offer about 10 hours of battery life — or up to 45 hours with the included charging case. And in typical Beats fashion, the earbuds deliver thumping base, though the overall sound quality falls short of the latest AirPods Pro.

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July 9, 2025
Trump singles out Brazil for 50 percent tariffs over Bolsonaro trial | Donald Trump News

United States President Donald Trump has continued to publish letters announcing individualised tariff hikes for foreign trading partners.

But on Wednesday, one of those letters was different from the rest.

While most of the letters are virtually identical, denouncing trade relationships that are “far from reciprocal”, Trump’s letter to Brazilian President Luiz Inacio Lula da Silva took a decidedly more personal — and more confrontational — approach.

“Due in part to Brazil’s insidious attacks on Free Elections, and the fundamental Free Speech Rights of Americans”, Trump wrote that he would be charging Brazil an extra 50-percent tax on any goods it exports to the US, separate from existing “sectoral tariffs”.

“Please understand that the 50% number is far less than what is needed to have the Level Playing Field we must have with your Country,” Trump added. “And it is necessary to have this to rectify the grave injustices of the current regime.”

The letter marked the biggest attack yet in Trump’s escalating feud with Lula, as he seeks to pressure Brazil to drop criminal charges against a fellow far-right leader, Jair Bolsonaro.

Known as the “Trump of the Tropics”, Bolsonaro, a former army captain, led Brazil for a single term, from 2019 to 2023.

Like Trump, Bolsonaro refused to concede his election loss to a left-wing rival. Like Trump, Bolsonaro also raised questions about the accuracy of the results, including by voicing doubts about electronic voting machines.

And like Trump, Bolsonaro has faced legal repercussions, with court cases weighing whether he could be criminally liable for alleged actions he took to overturn his defeat.

In Bolsonaro’s case, the election in question took place in October 2022, against the current president, Lula. The results were narrow, but Lula edged Bolsonaro out in a run-off race, earning 50.9 percent of the vote.

Still, Bolsonaro did not acknowledge his defeat and instead filed a legal complaint to contest the election results.

Meanwhile, his followers attacked police headquarters, blocked highways, and even stormed government buildings in the capital, Brasilia, in an apparent attempt to spark a military backlash against Lula.

Prosecutors, meanwhile, have accused Bolsonaro of conspiring with allies behind the scenes to stage a coup d’etat, one that might have seen Supreme Court justices arrested and a new election called.

According to the indictment, Bolsonaro, as the outgoing president, considered provoking these changes by calling a “state of siege”, which would have empowered the military to take action.

One of the other possibilities reportedly discussed was poisoning Lula.

Bolsonaro and 33 others were charged in February, and the ex-president’s case is ongoing before the Brazilian Supreme Court.

The charges came as the result of a federal police investigation published in November 2024, which recommended a criminal trial. Bolsonaro, however, has denied any wrongdoing and has framed the trial as a politically motivated attack.

Trump himself has faced two criminal indictments – one on the state level, the other federal – for allegedly seeking to overturn his loss in the 2020 election. He, too, called those cases attempts to derail his political career.

In recent days, Trump has highlighted what he sees as parallels between their cases. On July 7, he wrote on social media that he empathised with what was happening to Bolsonaro: “It happened to me, times 10.”

He reprised that theme in Wednesday’s letter, announcing the dramatic increase in tariffs against Brazil.

“The way that Brazil has treated former President Bolsonaro, a Highly Respected Leader throughout the World during his term, including by the United states, is an international disgrace,” Trump said.

“This trial should not be taking place,” he added. “It is a Witch Hunt that should end IMMEDIATELY!”

In addition to ramping up tariffs against Brazil, Trump revealed in his letter that he had directed US Trade Representative Jamieson Greer to investigate Brazil for unfair practices under the Trade Act of 1974.

This is not the first time that Trump has lashed out at Brazil, though. In February, the Trump Media and Technology Group filed a Florida lawsuit against Brazilian Supreme Court Justice Alexandre de Moraes, arguing that his decisions curtailed online freedom of speech in the US.

De Moraes had also overseen the investigation into Bolsonaro’s alleged coup attempt, and he is a target of criticism among many on the far right.

While Trump’s tariff letter contained the standard language alleging that the US’s trading relationship with Brazil was “very unfair”, the US actually enjoys a trade surplus with the South American country.

According to the Office of the US Trade Representative, in 2024, the US imported a total of $42.3bn from Brazil. But that was dwarfed by the amount it exported to the country: $49.7bn.

In short, Brazil’s purchases from the US amounted to about $7.4bn more than US purchases from Brazil.

Still, Trump has cited uneven trade relationships as the motivation for his tariffs, though he has also used them to influence other countries’ policies, particularly with regards to immigration, digital services and transnational drug smuggling.

On Wednesday, Bolsonaro took to social media to once again proclaim his innocence. In a separate case, he was barred from holding public office in Brazil for a period of eight years.

“Jair Bolsonaro is persecuted because he remains alive in the popular consciousness,” the ex-president wrote in the third person. “Even out of power, he remains the most remembered name – and the most feared. That’s why they try to annihilate him politically, morally, and judicially.”

He also reposted a message from Trump himself: “Leave the Great Former President of Brazil alone. WITCH HUNT!!!”

Lula, meanwhile, responded to Trump’s previous tariff threats on Monday by saying, “The world has changed. We don’t want an emperor.”

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July 9, 2025
EC adopts low-carbon hydrogen rules setting 70% CO2 emissions savings – S&P Global
1. EC adopts low-carbon hydrogen rules setting 70% CO2 emissions savings S&P Global
2. New EU Energy and Raw Materials Platform to support the competitiveness and decarbonisation of European industry Energy
3. EC adopts legislation to boost low-carbon hydrogen output Montel News
4. Hydrogen: Commission accommodates gas industry Table.Media
5. EU’s low-carbon hydrogen and fuel industry receive new emissions savings methodology MLex
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July 9, 2025
Prime Day Deal: UE’s Wonderful Wonderboom 4 Speaker Is on Sale for 34% Off

If you’re like me, you listen to music or a podcast while taking a shower. Sure, modern smartphones are IP-rated to handle such conditions, but hearing horror stories about destroyed electronics still makes me want a buffer between my phone and running water.

A waterproof Bluetooth speaker like the UE Wonderboom 4 is exactly the kind of buffer I prefer. For Amazon Prime Day, it’s on sale for $66 (34% off). Only the black and blue versions are 34% off, but you can get the gray or pink ones for $70, or 30% off.

The coolest part about this speaker is that it floats. That means you can take it to the pool, drop it in (accidentally or on purpose) and it’ll float on top of the water. It has an IP67 rating, which means it can handle being submerged in up to three feet of water for 30 minutes. Since it floats, it’ll rarely ever reach those depths. The dust resistance means it’ll handle larger particles like dirt and sand without notable issue. In short, there are few Bluetooth speakers on the market suited for a beach trip like the Wonderboom 4.

UE designs these things with 360-degree sound, so you don’t need to worry about directionality like some other Bluetooth speakers. They’re also small enough to carry in one hand, making them easy to carry along on hikes or camping trips.

The UE Wonderboom is small enough to hold in one hand, making it easy to bring it with you.

UE

Other than that, what you see is what you get. It delivers 10W of power, which is enough for background music while hanging out at the beach or listening to jazz at the pool. You’ll want a larger Bluetooth speaker if you need your tunes to fill large areas. The speaker also comes with a Podcast Mode, which increases bumps up the frequency response where vocals typically are, making voices sound louder and fuller.

Looking for more Prime Day deals? CNET’s text deals are an easy way to keep up with the latest sales. Did we mention that it’s free?

The UE Wonderboom 4 is great for its use case, which is carrying it around and listening to music around water. That said, it’s a pretty small speaker, and small speakers don’t have the biggest output. If you’re in search of something louder with a little more audiophilia baked in, we recommend checking out the best-sounding Bluetooth speakers as tested by CNET.

BLUETOOTH SPEAKER DEALS OF THE WEEK

Deals are selected by the CNET Group commerce team, and may be unrelated to this article.

Not a bad value for under $100

The Wonderboom 4 is a good value when it goes on sale like this. For under $70, you can get something you can take with you almost anywhere. The fact that it floats means it was tailor-made for watery environments, which is another thing not every Bluetooth speaker boasts. Though it’s not the lowest price we’ve ever seen, who wants to wait for Black Friday, which is four months away? Beach season is right now.

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July 9, 2025
Asian Stocks to Rally After Tech Lifts S&P 500: Markets Wrap
This content was published on

July 10, 2025 – 01:25

(Bloomberg) — Asian equities were set to join a rally in US shares and Bitcoin in a sign investors are looking through the latest tariff headlines to focus on corporate profits and the economy.

Equity-index futures for Japan and Australia climbed early Thursday while those for Hong Kong were flat. The S&P 500 rose 0.6% and the Nasdaq 100 climbed 0.7%, helped along by tech gains that pushed Nvidia Corp to become the first company in history to touch $4 trillion in market value. The real tumbled after President Donald Trump unveiled a new round of trade demand letters on Wednesday that included imposing 50% tariffs on Brazilian goods.

Investors have been piling back into the AI trade after a choppy first half of 2025. The equity rally indicated traders were brushing off fears Trump’s latest push on reciprocal tariffs would lead to a meaningful slowdown for the global economy or company earnings.

“Most investors believe that the economy is strong, corporate profits will be resilient and are eager to buy stocks,” said Chris Zaccarelli at Northlight Asset Management. “We believe more caution is warranted because we haven’t yet seen the impact of tariffs on corporate profits and consumer spending,” he said.

Treasuries climbed Wednesday after a solid $39 billion sale, snapping a recent sell-off. US 10-year yields fell seven basis points to 4.33%. A sale of the bonds drew a yield of 4.362%, slightly lower than indicated by pre-auction trading just before the bidding deadline, indicating demand exceeded expectations. A $22 billion offering of 30-year debt is set for Thursday.

The emerging divide among Federal Reserve officials over the outlook for interest rates is being driven largely by differing expectations for how tariffs might affect inflation, a record of policymakers’ most recent meeting showed.

“While a few participants noted that tariffs would lead to a one-time increase in prices and would not affect longer-term inflation expectations, most participants noted the risk that tariffs could have more persistent effects on inflation,” the minutes of the Federal Open Market Committee’s June 17-18 meeting said.

On tariffs, Trump on Wednesday said he would levy a 30% rate on Algeria, Libya, Iraq and Sri Lanka, with 25% duties on products from Brunei and Moldova and a 20% rate on goods from the Philippines. The levies were largely in line with rates Trump had initially announced in April against those countries, though Iraq’s duties are down from 39% and Sri Lanka’s reduced from 44%.

Brazil’s 50% rate marked one of the highest levies announced so far, and are set to hit in August. Trump cited the treatment of former President Jair Bolsonaro in his letter to the nation, calling on authorities to drop charges against him over an alleged coup attempt. Brazil will respond to the US using its reciprocity law, President Luiz Inacio Lula da Silva said.

Elsewhere, an auction of 20-year Japanese government bonds Thursday will beam the searchlight back on rising yields as a looming election heightens concerns about fiscal expansion. Japanese telecom giant NTT Inc. received more than $100 billion of investor orders as it sold bonds to help refinance bridge loans used to increase its stake in the data-center unit being taken private.

Wednesday’s equity rally pushed the S&P 500 to within a few points of its record high. The CNN Fear & Greed Index is now signaling “extreme greed,” an indication of the market’s bullish momentum. A gauge of megacaps added 1.1%, with Nvidia extending this year’s surge to more than 20%. In another sign of risk appetite, Bitcoin topped $112,000 for the first time.

Fast-money investors are edging their way back into US stocks after sitting out a furious rally, bolstering the case for equities to extend their advance further into uncharted territory.

“We believe the setup for equity markets looks bullish, even in light of renewed trade-war jitters,” said Craig Johnson at Piper Sandler. “While equities may come under some near-term pressure, investors are increasingly becoming numb to the tariff headlines and instead focusing on the trendlines.”

Some of the main moves in markets:

Stocks
- S&P 500 futures were little changed as of 8:19 a.m. Tokyo time
- Hang Seng futures were little changed
- S&P/ASX 200 futures rose 0.5%
Currencies
- The Bloomberg Dollar Spot Index was little changed
- The euro was little changed at $1.1724
- The Japanese yen was little changed at 146.19 per dollar
- The offshore yuan was unchanged at 7.1828 per dollar
- The Australian dollar was little changed at $0.6536
Cryptocurrencies
- Bitcoin rose 0.6% to $111,472.81
- Ether rose 1.4% to $2,778.31
Bonds
- Australia’s 10-year yield declined six basis points to 4.28%
Commodities
- West Texas Intermediate crude fell 0.3% to $68.17 a barrel
- Spot gold rose 0.1% to $3,318.52 an ounce
This story was produced with the assistance of Bloomberg Automation.

–With assistance from Richard Henderson.

©2025 Bloomberg L.P.
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July 9, 2025
Deflecting Asteroids Isn’t Simple According to New Data from DART

We know that there are many asteroids in the Solar System that pose a potential threat. We’re getting better at detecting them, and every few months we learn of another one on a potential course to strike Earth. It’s obviously in our best self-preservation interest to detect these objects and to figure out how to protect the planet from them. That’s what led to NASA’s DART (Double-Asteroid Redirection Test).

DART was sent to the double asteroid Didymos and its small moonlet Dimorphos to act as a kinetic impactor. It slammed into the smaller Dimorphos on September 26th, 2022, and then ground-based facilities watched to see the results. The impact shortened Dimorphos’ orbit by 32 minutes which constituted a stunning success, since pre-mission success was defined as only a 73 second orbital change.

But in a way, the impact was too successful. This is outlined in a new paper in The Planetary Science Journal titled “High-speed Boulders and the Debris Field in DART Ejecta.” The lead author is Tony Farnham, a research scientist at the University of Maryland’s Department of Astronomy.

“We succeeded in deflecting an asteroid, moving it from its orbit,” Farnham said in a press release. “Our research shows that while the direct impact of the DART spacecraft caused this change, the boulders ejected gave an additional kick that was almost as big. That additional factor changes the physics we need to consider when planning these types of missions.”

LICIACube (Light Italian Cubesat for Imaging of Asteroids) is a small, 14kg CubeSat supplied by the Italian Space Agency as part of the DART mission. It carried a pair of cameras and was released from DART as the spacecraft sped up for its impact with Dimorphos. As DART impacted Dimorphos, LICIACube took an image every six seconds. It captured images of the impact and its ejecta, as well as images of Didymos’ morphology.

LICIACube documented the aftermath of the impact from 29 to 243 s after the impact. The CubeSat images allowed astronomers to track 104 boulders ranging from 0.2 to 3.6 meters in radius. The researchers also estimate an additional 30–40 objects ≤0.5 m that were too dim to track. The 104 boulders sped away from the impact at 52 meters per second (116 miles per hour). Surprisingly, the boulders’ paths were not random.

This figure shows the sizes of the 104 boulders ejected form Dimorphos, with error bars in grey. Image Credit: Farnham et al. 2025. TPSJ

“We saw that the boulders weren’t scattered randomly in space,” Farnham said. “Instead, they were clustered in two pretty distinct groups, with an absence of material elsewhere, which means that something unknown is at work here.”

The largest debris cluster contained about 70% of the objects. It was deflected to the south and had high velocities and shallow angles. The researchers think that the boulders in this cluster may have come from a source on Didymos like larger boulders that were blasted into pieces by DART’s solar panels as it struck the tiny asteroid.

This figure shows four images from LICIACube. It compares calibrated images from NASA’s Planetary Data System, a long-term archive of NASA mission images, in A and C, with new reduced images from the research in B and D. The new images remove some artificial background structure and makes the ejecta details easier to see. Image Credit: NASA/Farnham et al. 2025. TPSJ

“DART’s solar panels likely hit two big boulders, called Atabaque and Bodhran, on the asteroid,” explained the paper’s second author, Jessica Sunshine. Sunshine is a professor of astronomy and geology at the University of Maryland. “Evidence suggests that the southern cluster of ejected material is probably made up of fragments from Atabaque, a 3.3-meter-radius boulder.”

This image is from one of LICIACube’s cameras, overlain with Dart and its solar panels shown with white outlines. The pair of boulders struck by the panels are labelled, and coloured lines represent the boulder debris ejected by the impact. Image Credit: Farnham et al. 2025. TPSJ

“Our analysis of the spatial distribution of 104 of these boulders suggests that they are likely the remnants of larger boulders shattered by the DART spacecraft in the first stages of the impact,” the researchers write in their paper. “The amount of momentum contained in these boulders is more than 3 times that of the DART spacecraft, and it is directed primarily to the south, almost perpendicular to the DART trajectory.”

This figure from the research plots the azimuth/elevation angle trajectories derived for the 104 boulders measured by the researchers. It shows their locations in the sky if viewed from the impact site. It shows their velocities and their radii, and clearly shows how the boulders mostly form two distinct groups. Only a few others are scattered in between. The pink are shows the exclusion zone where ejecta would not be seen by LICIACube. The dashed blue line represents the projection of the walls of the dust ejecta cone. Image Credit: Farnham et al. 2025. TPSJ

The DART mission draws comparisons to NASA’s 2005 mission, Deep Impact. Deep Impact was designed to answer fundamental questions about comets. It rendezvoused with the comet Tempel 1 and released a kinetic impactor that impacted the comet’s nucleus and excavated a crater.

The comparisons between DART and Deep Impact are all the more relevant because co-author Jessica Sunshine was the deputy principal investigator for Deep Impact. When it comes to defending Earth from impacts, comets are also a hazard, though less numerous than asteroids.

“Deep Impact hit a surface that was essentially very small, uniform particles, so its ejecta was relatively smooth and continuous,” Sunshine explained. “And here, we see that DART hit a surface that was rocky and full of large boulders, resulting in chaotic and filamentary structures in its ejecta patterns. Comparing these two missions side-by-side gives us this insight into how different types of celestial bodies respond to impacts, which is crucial to ensuring that a planetary defense mission is successful.”

The team calculated that the 104 boulders carried a total kinetic energy equaling about 1.4% of the energy of the DART spacecraft. Most of that energy was directed to the south. “With 96% of the momentum from the boulders directed to the south, it is also likely that Dimorphos’ s orbital plane inclination was changed by the impact,” the authors write. “These boulders also represent significant momentum contributions that were not accounted for in the orbital period measurements,” they explain. Accounting for all of this energy means that the measurement originally obtained in the DART experiment need to be updated. The energy of the boulders likely led to a slight inclination of Dimorphos orbit relative to Didymos equator.

The results also reveal more about what to expect when impactors are sent to collide with rubble-pile asteroids. “These results, along with the filamentary structures in the ejecta cone, will provide unique insights into the physics regarding impacts into rubble-pile asteroids, where material on and under the surface can have important implications for the temporal and spatial evolution of the ejecta,” the authors write in their research.

If scientists had to rely only on ground-base observations of the DART impact, they never would’ve learned about the boulder ejecta. LICIACube provided important information about the variable in planning future asteroid impact missions. (The Hubble Space Telescope spotted 37 boulders from the DART impact but it’s observations weren’t as detailed as LICIACube’s.)

LICIACube isn’t the only mission to study the impact aftermath from the DART mission. The ESA’s Hera mission is on its way to investigate the impact in more detail.

“Data gathered from LICIACube provides additional perspectives on impact events, especially as DART was originally designed to solely rely on Earth-based observations,” Farnham said. “Hera will do the same by giving us another direct view of the impact’s aftermath, relying on the predictions we’ve made using data gathered from DART.”

Asteroid deflection works every time in books and movies, but in reality, there are a lot more variables.

“If an asteroid was tumbling toward us, and we knew we had to move it a specific amount to prevent it from hitting Earth, then all these subtleties become very, very important,” Sunshine added. “You can think of it as a cosmic pool game. We might miss the pocket if we don’t consider all the variables.”

In their paper’s conclusion, the researchers explain that a full accounting of momentum in all directions and an understanding of what role surface boulders played will help them understand how a kinetic impactor affects an asteroid. “Finally, the contributions from the boulder momentum suggest that Hera may encounter a Didymos system in which Dimorphos is tumbling in an orbit that has a slight inclination to Didymos’ s equator,” they conclude.

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July 9, 2025
Decitabine/Cedazuridine Plus Venetoclax sNDA Under FDA Review for Newly Diagnosed AML
Decitabine/Cedazuridine Plus Venetoclax
in AML | Image Credit: © LELISAT – stock.adobe.com

The FDA has accepted for review a supplemental new drug application (sNDA) seeking the approval of decitabine and cedazuridine (Inqovi) plus venetoclax (Venclexta) for the treatment of adult patients with newly diagnosed acute myeloid leukemia (AML) who are not eligible for intensive induction chemotherapy.¹

This submission was based on findings from the single-arm phase 2b ASCERTAIN-V trial (NCT04657081), which were presented at the 2025 ASCO Annual Meeting and the 2025 EHA Congress. ASCERTAIN-V investigated decitabine plus cedazuridine and venetoclax in 101 adult patients with newly diagnosed AML who were ineligible for intensive induction chemotherapy. At a median follow-up of 11.2 months, the trial met its primary end point, with a complete response (CR) rate of 46.5% (95% CI, 36.5%-56.7%) in the total population.^2,3 Additionally, the rate of CR/CR with incomplete hematologic recovery was 63.4% (95% CI, 53.2%-72.7%), and the rate of CR/CR with partial hematologic recovery was 51.5% (95% CI, 41.3%-61.6%). The estimated median overall survival was 15.5 months (95% CI, 7.6-not evaluable). At 12 months, the median duration of response was not reached, and 75.3% of patients who had achieved CR remained in CR.

Moreover, subgroup analyses showed consistent CR rates across prespecified patient subgroups. Notably, high CR rates were observed in patients younger than 76 years of age (57.9%; 95% CI, 33.5%-79.7%), as well as those with a baseline ECOG performance status of 0 (51.9%; 95% CI, 31.9%-71.3%). Additionally, the CR rate was 48.8% (95% CI, 37.9%-59.9%) among patients who had received no prior anticancer therapies.

“We have an unwavering dedication to developing innovative new cancer treatments, and the FDA’s acceptance of our sNDA for [decitabine plus cedazuridine] in combination with venetoclax highlights the need for novel approaches in AML,” Harold Keer, MD, PhD, chief medical officer of Taiho Oncology, stated in a news release.¹ “If approved for patients with AML who are not eligible to undergo intensive induction chemotherapy, [decitabine plus cedazuridine] in combination with venetoclax would offer the first all-oral alternative to current therapies.”

In ASCERTAIN-V, patients received decitabine plus cedazuridine on days 1 through 5 of each 28-day treatment cycle, in combination with daily venetoclax. Patients continued treatment until disease progression, unacceptable toxicity, or patient withdrawal from the study.²

Investigators reported no new safety concerns with the combination.^1-3 In total, 99.0% of patients experienced any adverse effects (AEs), 80.2% of patients experienced treatment-related AEs, 84.2% of patients experienced serious AEs, and 35.6% of patients experienced treatment-related serious AEs. Additionally, 98.0% of patients experienced grade 3 or higher AEs, the most common being febrile neutropenia (49.5%), anemia (38.6%), and neutropenia (35.6%). Other grade 3 or higher AEs included decreased platelet counts (24.8%), thrombocytopenia (19.8%), decreased neutrophil count (19.8%), decreased white blood cell counts (14.9%), and decreased appetite (1.0%).

AEs leading to treatment discontinuation (8.9%), treatment interruption (68.3%), and dose reduction (13.9%) were reported. At 30 days after the first dose of decitabine plus cedazuridine, 3 deaths were attributed to either AEs or disease progression; this number rose to 10 deaths at 60 days.

Notably, pharmacokinetic analyses confirmed that no drug-drug interactions occurred between decitabine/cedazuridine and venetoclax. Additionally, the pharmacokinetics of decitabine and cedazuridine were not affected by venetoclax.^2,3

Previously, decitabine plus cedazuridine was FDA approved in July 2020 for the treatment of adult patients with select subtypes of previously untreated de novo and secondary myelodysplastic syndromes, including those with chronic myelomonocytic leukemia.⁴

References
1. Taiho Oncology and Taiho Pharmaceutical announce U.S. FDA acceptance of supplemental new drug application for Inqovi in combination with venetoclax to treat patients with acute myeloid leukemia. News release. Taiho Oncology, Inc., and Taiho Pharmaceutical Co., Ltd. July 9, 2025. Accessed July 9, 2025. https://www.taihooncology.com/us/news/taiho-oncology-and-taiho-pharmaceutical-announce-us-fda-acceptance-of-supplemental-new-drug-application-for-inqovi-in-combination-with-venetoclax-to-treat-patients-with-acute-myeloid-leukemia/
2. Zeidan AM, Griffiths EA, Dinardo CD, et al. An all-oral regimen of decitabine-cedazuridine (DEC-C) plus venetoclax (VEN) in patients (pts) with newly diagnosed acute myeloid leukemia (AML) ineligible for intensive induction chemotherapy: results from a phase 2 cohort of 101 pts. J Clin Oncol. 2025;43(suppl 16):6504. doi: 10.1200/JCO.2025.43.16_suppl.6504
3. Roboz G, Zeidan AM, Mannis G, et al. All-oral decitabine-cedazuridine (Dec-C) + venetoclax (Cen) in patients with newly diagnosed acute myeloid leukemia (AML) ineligible for induction chemotherapy: phase 1/2 clinical trial results. Presented at: 2025 European Hematology Association Congress; June 12-15, 2025; Milan, Italy. Abstract S135.
4. FDA approves oral combination of decitabine and cedazuridine for myelodysplastic syndromes. FDA. July 7, 2020. Accessed July 9, 2025. https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-oral-combination-decitabine-and-cedazuridine-myelodysplastic-syndromes
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July 9, 2025
Sam Asghari breaks silence on Britney Spears trash talking

Sam Asghari breaks silence on Britney Spears trash talking – Daily Times