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  • Check Point Software Technologies Named a Leader in Zero Trust Platforms, Q3 2025 Evaluation

    Check Point Software Technologies Named a Leader in Zero Trust Platforms, Q3 2025 Evaluation

    Check Point® Software Technologies Ltd. (NASDAQ: CHKP), a pioneer and global leader of cyber security solutions, today announced it has been recognized as a Leader in The Forrester Wave™: Zero Trust Platforms, Q3 2025. The independent analyst report evaluated the 10 most significant Zero Trust platform providers and cited Check Point for delivering a unified, prevention-first security platform that covers network, cloud, and endpoint controls across hybrid environments.

    Check Point received the highest possible scores (5 out of 5) in four critical criteria within the current offering category: centralized management and usability, least-privileged-access enforcement, segmentation and control, and deployment. The company also received 5/5 scores in the roadmap and supporting services and offerings criteria within the strategy category, which Check Point believes reinforces its strong vision and customer-centric approach.

    “This recognition by Forrester affirms, for us, Check Point’s leadership in delivering consistent Zero Trust security that is comprehensive, intuitive, and built for the AI-driven, hyperconnected world,” said Nataly Kremer, Chief Product Officer at Check Point Software. “Our AI-powered Infinity Platform is purpose-built to help organizations secure users, assets, and data — wherever they reside — through centralized management, intelligent policy enforcement, and flexible deployment across cloud, on-prem, and hybrid environments.”

    Check Point’s highlights from the report include:

    • Centralized Management
    • Least-Privileged Access Enforcement
    • Segmentation and control
    • Deployment
    • Roadmap
    • Supporting services and offerings

    Forrester also noted that organizations looking for a centralized, easy-to-manage, and holistic network security platform for local networks should include Check Point on their shortlist.

    For Check Point, this position as a leader reinforces the company’s commitment to a prevention-first strategy, helping enterprises proactively secure their infrastructure against modern threats while accelerating their Zero Trust adoption.Learn more on our blog and access a complimentary copy of The Forrester Wave™: Zero Trust Platforms, Q3 2025 here.

    Forrester does not endorse any company, product, brand, or service included in its research publications and does not advise any person to select the products or services of any company or brand based on the ratings included in such publications. Information is based on the best available resources. Opinions reflect judgment at the time and are subject to change. For more information, read about Forrester’s objectivity here.

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  • Pakistan issues ordinance to regulate virtual assets, establishes regulatory authority

    ISLAMABAD: On Thursday, President Asif Ali Zardari signed the Virtual Assets Regulatory Authority (Vara) Ordinance 2025, which establishes a new body to regulate virtual asset services in Pakistan. The ordinance aims to tackle money laundering and terrorist financing while ensuring the proper oversight of virtual asset transactions within the country.

    The ordinance comes into immediate effect nationwide, with the authority’s head office located in Islamabad, although regional offices can be set up as needed. Vara will operate as a corporate entity, granting it the authority to acquire property, engage in contracts, make purchases and sales, and even file legal cases.

    The new regulatory body will oversee the issuance, suspension, and revocation of licenses for virtual asset service providers. It will also regulate the virtual assets sector, enforce anti-money laundering and anti-terrorism financing measures, and have the power to investigate, impose fines, and take disciplinary actions.

    The ordinance stipulates that a board will govern Vara, with the chairman and two members representing the Finance and Law Ministries. The board may include additional advisers. The chairman and non-official members will serve for a term of three years.

    Furthermore, the ordinance mandates that no individual or entity may provide virtual asset services without a license from Vara. It also specifies that those offering such services without proper authorization may face fines.

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  • China to take active part in promoting comprehensive strategic partnership with Australia: FM

    KUALA LUMPUR: China is ready to promote the comprehensive strategic partnership with Australia through a more proactive approach, Chinese Foreign Minister Wang Yi said here on Friday.

    China is willing to work with Australia to prepare for the next stage of high-level exchanges, maintain the momentum of improvement in bilateral ties and properly manage their differences, Wang said.

    Wang made the remarks during a meeting with Australian Foreign Minister Penny Wong in the Malaysian capital on the sidelines of the ASEAN Foreign Ministers’ Meeting and related meetings.

    Over the past three years, China-Australia relations have stabilized, turned around and achieved positive results, said Wang, also a member of the Political Bureau of the Communist Party of China Central Committee.

    It proves that as long as the two countries uphold a correct positioning of their partnership, bilateral relations can develop steadily and continue to yield results, Wang said.

    The Chinese foreign minister noted that Australia’s rational and pragmatic policy toward China serves the interests of both countries and aligns with the trend of the times.

    For her part, Wong said that Australia is committed to developing a positive and pragmatic relationship with China.

    Both sides are making every effort to prepare for high-level exchanges and look forward to achieving positive outcomes, she said, adding that dialogue and cooperation between Australia and China in trade, tourism and other fields have continued to make progress, and personnel exchanges have become increasingly active.

    Wong noted that Australia remains firmly committed to the one-China policy and does not support “Taiwan independence.”

    Australia is willing to engage in candid communication and deepen cooperation with China to promote the sustained and positive development of bilateral relations, she said.

    Wong said that Australia supports the central role of ASEAN and is committed to maintaining regional peace and stability.

    The two sides also exchanged views on issues including the South China Sea and the Ukraine crisis.

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  • Spotlight on Schizophrenia Data: Insights From Recent Conferences

    Spotlight on Schizophrenia Data: Insights From Recent Conferences

    Check out new data on the schizophrenia treatment pipeline from recent spring conferences—the American Society of Clinical Psychopharmacology (ASCP) Annual Meeting in Scottsdale, Arizona, and the American Psychiatric Association Annual Meeting in Los Angeles, California. Complete coverage of this year’s meeting as well as previous meetings can be found at PsychiatricTimes.com.

    NBI-1117568: Positive Phase 2 Results From the 2025 ASCP Annual Meeting

    Leah Kuntz

    Neurocrine Biosciences, Inc, shared data from a phase 2 study of NBI-1117568 in adults with schizophrenia, which showed a significant improvement in symptoms and overall severity and highlighted new data on the safety and tolerability of the treatment. NBI-1117568 is the first and only investigational oral muscarinic M4 selective orthosteric agonist in clinical development as a potential treatment for schizophrenia.1

    “Traditional treatment approaches for schizophrenia can lead to significant short- and long-term challenges and often result in discontinuation of therapy. Given these challenges, there is a continued need for new, effective, and tolerable treatment options,” said Eiry W. Roberts, MD, chief medical officer at Neurocrine Biosciences.1 “This compound is promising, as it is a direct and selective muscarinic M4 receptor agonist, which is believed to be a key regulator of neurotransmitters impacted by schizophrenia, and we look forward to advancing its development in the phase 3 registrational program.”

    In a 6-week, double-blind, placebo-controlled, dose-finding study, 210 adults aged 18 to 55 years with a primary diagnosis of schizophrenia who experienced an acute exacerbation or relapse of symptoms were randomly assigned 2:1 to either NBI-1117568 (20 mg, 40 mg, or 60 mg once daily or 30 mg twice daily) or placebo. Other antipsychotics were not allowed during the study. Participants were then seen at a 2-week safety follow-up. The primary end point was the change in total Positive and Negative Syndrome Scale (PANSS) score from baseline to week 6. The study showed statistically significant improvements in the PANSS total score with 20 mg of NBI-1117568 once daily by week 3 and at all subsequent visits through week 6. A statistically significant improvement was also observed by week 2 in the Clinical Global Impressions–Severity (CGI-S) scale, with continued improvement seen at all following visits through week 6. For all other doses (40 mg and 60 mg once daily, 30 mg twice daily), mean decreases from baseline at week 6 in the PANSS total and CGI-S scale scores were greater with NBI-1117568 than with placebo but not statistically significant.2

    NBI-1117568 was generally safe and well tolerated at all doses. Treatment discontinuation rates due to adverse events were similar between NBI-1117568 and placebo. Adverse events with the highest incidence for NBI-1117568 compared with placebo were somnolence (10.7% vs 2.9%, respectively) and dizziness (9.3% vs 1.4%). Increases in heart rate were transient, attenuated over the course of treatment, and not clinically meaningful. No weight gain was associated with the NBI-1117568 treatment groups relative to placebo.1

    References

    1. Neurocrine Biosciences presents new positive data from phase 2 study of NBI-1117568 in adults with schizophrenia at American Society of Clinical Psychopharmacology 2025. News release. Neurocrine Biosciences Inc. May 28, 2025. Accessed May 29, 2025. https://www.prnewswire.com/news-releases/neurocrine-biosciences-presents-new-positive-data-from-phase-2-study-of-nbi-1117568-in-adults-with-schizophrenia-at-american-society-of-clinical-psychopharmacology-2025-302467554.html

    2. Kuntz L. New positive results for NBI-1117568 in adults with schizophrenia. Psychiatric Times. August 28, 2024. https://www.psychiatrictimes.com/view/new-positive-results-for-nbi-1117568-in-adults-with-schizophrenia

    New Data on CPL’36 for the Treatment of Acute Schizophrenia Exacerbation

    Heidi Anne Duerr, MPH

    Investigators presented data from a double-blind, randomized, placebo-controlled, parallel-group phase 2 study on CPL500036 (CPL’36), a phosphodiesterase 10A inhibitor intended to treat acute schizophrenia exacerbation.1,2 The dose-ranging study was designed to investigate the efficacy, safety, tolerability, and pharmacokinetics across 2 doses of CPL’36. The investigators defined the primary end point as a change from baseline in the PANSS positive subscale at day 28. They also looked at the change from baseline in the PANSS total and negative subscale scores and change from baseline in the Brief Assessment of Cognition in Schizophrenia score at weeks 2 and 4.

    Participants (N = 189) included patients with acute exacerbation of schizophrenia. Baseline severity as measured by the PANSS was severe and moderate to severe, with a PANSS total score of approximately 106. Patients were randomly assigned at an equal ratio (1:1:1) to either one of the active doses, 20 mg CPL’36 or 40 mg CPL’36, or the placebo. All doses were administered once daily for 28 consecutive days.

    At 4 weeks, investigators found improvement across all the studied PANSS scores. Specifically, patients receiving the 20-mg dose realized a 3.7-unit improvement from baseline (least square [LS] mean difference from placebo, P < .001, Cohen d = 0.73) on the positive PANSS subscale score, and participants receiving the 40-mg dose realized a 6.3-unit reduction (LS mean difference from placebo, P < .001, Cohen d = 1.38). Larger reductions were found on the total PANSS score at week 4 of treatment. Investigators recorded a 9.7-unit reduction from baseline among patients who received the 20-mg dose of CPL’36 compared with placebo (LS mean difference from placebo, P < .001, Cohen d = 0.77). Those who received the 40-mg dose demonstrated a 16.4-unit reduction (LS mean difference from placebo, P < .001, Cohen d = 1.47). The investigators also noted 2.6-unit reductions on the negative PANSS subscale score at week 4 of treatment for the participants who received the 40-mg dose of CPL’36 (LS mean difference from placebo, P < .001, Cohen d = –0.968). Overall, CPL’36 appeared to have a good safety profile.1

    “CPL’36 demonstrated beneficial effects across multiple aspects of schizophrenia pathophysiology,” Jazwiec et al wrote.1 “These encouraging results support the continued development of CPL’36 as a drug candidate for the treatment of psychotic disorders.”

    References

    1. Jazwiec R, Rudzki P, Wieczorek et al. Cpl’36 Pde10a inhibitor is highly effective in the treatment of acute exacerbations from a phase 2 clinical trial. Presented at: American Psychiatric Association Annual Meeting; May 17-21, 2025; Los Angeles, CA.

    2. Efficacy, safety and pharmacokinetics study of CPL500036 (PDE10A inhibitor) in patients with schizophrenia. ClinicalTrials.gov. Updated July 11, 2024. Accessed May 18, 2025. https://clinicaltrials.gov/study/NCT05278156

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  • Stellan Skarsgård on Ingmar Bergman: ‘The only person I know who cried when Hitler died’ | Stellan Skarsgård

    Stellan Skarsgård on Ingmar Bergman: ‘The only person I know who cried when Hitler died’ | Stellan Skarsgård

    Stellan Skarsgård has weighed in on famed director Ingmar Bergman’s Nazi sympathies as a young adult.

    The actor was speaking at the Karlovy Vary film festival in the Czech Republic, where he was promoting Joachim Trier’s film Sentimental Value, inspired by the late Swedish director. Skarsgård expressed his personal dislike of Bergman, with whom he worked on a 1986 stage production of August Strindberg’s A Dream Play.

    “Bergman was manipulative,” said the 74-year-old Swedish actor, as first reported by Variety. “He was a Nazi during the war and the only person I know who cried when Hitler died. We kept excusing him, but I have a feeling he had a very weird outlook on other people. [He thought] some people were not worthy. You felt it, when he was manipulating others. He wasn’t nice.”

    Bergman, who died in 2007 at the age of 89, spoke openly of his past sympathies for nazism while growing up in a rightwing Swedish family.

    In 1999, the director explained to Maria-Pia Boëthius, author of a book questioning Sweden’s neutrality during the second world war, his positive feelings for Hitler after attending a Nazi rally during an exchange trip to Germany in 1934, at the age of 16. “Hitler was unbelievably charismatic. He electrified the crowd,” he said.

    He added that his family put a photo of the fascist dictator next to his bed after, because “the nazism I had seen seemed fun and youthful.” The book also details how Bergman’s brother and friends vandalized the house of a Jewish neighbor with swastikas – and that he was “too cowardly” to raise objections to the attack.

    The director also acknowledged his past Nazi sympathies in his 1987 memoir The Magic Lantern: “For many years, I was on Hitler’s side, delighted by his success and saddened by his defeats.” He told Boëthius that he maintained support for the Nazis until the end of the war, when the exposure of Nazi atrocities in the Holocaust changed his views. “When the doors to the concentration camps were thrown open,” he said, “I was suddenly ripped of my innocence.” Bergman went on to explore anguish over the horrors of war in such films as Winter Light, The Silence and Shame.

    This is not the first time Skarsgård has criticized Bergman openly – in a 2012 interview with the Guardian’s Xan Brooks, Skarsgård said of Bergman: “I didn’t want him near my life.”

    “My complicated relationship with Bergman has to do with him not being a very nice guy,” he said at Karlovy Vary. “He was a nice director, but you can still denounce a person as an asshole. Caravaggio was probably an asshole as well, but he did great paintings.”

    Sentimental Value, which premiered to rave reviews at May’s Cannes film festival, is tipped for awards success later this year.

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  • What’s behind Gen Z’s sex recession? : NPR

    What’s behind Gen Z’s sex recession? : NPR



    (SOUNDBITE OF MUSIC)

    BRITTANY LUSE, HOST:

    Hello, hello. I’m Brittany Luse, and you’re listening to IT’S BEEN A MINUTE from NPR, a show about what’s going on in culture and why it doesn’t happen by accident.

    (SOUNDBITE OF MUSIC)

    LUSE: A warning – this segment discusses sex and sexuality.

    (SOUNDBITE OF MUSIC)

    LUSE: OK. So I personally enjoy Sabrina Carpenter. But she got into some backlash recently. What was that about?

    CARTER SHERMAN: Well, she put out a new album cover for her forthcoming album, “Man’s Best Friend,” where she not so subtly looked like she was pretending to be a dog, held by her own hair as a kind of leash by a man.

    TOBIAS HESS: Yeah. It sparked a real wave of discourse, and it felt incredibly silly to me because it’s almost like the whole internet was debating a poster that said the word sex.

    (SOUNDBITE OF MUSIC)

    LUSE: This week, we’re connecting the dots between hot discourse, Sabrina Carpenter and the youths. I know, I know. How are all of these things connected? Well, we’re going to find out with Tobias Hess, contributing writer at Paper Magazine and writer of the Gen Zero Substack, and Carter Sherman, reproductive health and justice reporter at The Guardian and author of “The Second Coming: Sex And The Next Generation’s Fight Over Its Future.” Carter, Tobias, welcome to IT’S BEEN A MINUTE.

    SHERMAN: Thank you for having us.

    HESS: Great to be here.

    LUSE: You know, I mean, Sabrina Carpenter has been getting criticism for a while now for being too sexy – notably for cheekily simulating sex positions while performing her song “Juno” during her concerts on tour, and it seems very, very, very tongue in cheek and not necessarily explicit, just to make that clear for the listener. And it seems to me, though, that this, like, criticism, this backlash, is coming from a particular demographic, Gen Z. There’s a tweet that came up during some of this discourse that sums it up, I think – quote, “I’m 17 and afraid of Sabrina Carpenter when she’s performing.”

    SHERMAN: (Laughter).

    LUSE: I don’t want to fall into the trap of saying this kind of discourse is representative of how all or even most of Gen Z thinks about sex and sexuality, but Gen Z is having less sex than previous generations at the same age. Some describe this decline as a sex recession. Carter, you talked to over a hundred members of Gen Z, and Tobias, you are Gen Zer yourself. Do you feel like some of this sex-negative discourse actually reflects what’s going on with Gen Z?

    SHERMAN: Well, it is undeniably true that Gen Z is having sex later and less than past generations. One in four adult members of Gen Z have not had sex and, in fact, also only a third of Gen Zers in high school have had sex, which is down from about half when I was in high school. I’m a millennial. But in my conversations with young people, I did not find them to be, quote-unquote, “sex negative.” If anything, I feel like they felt really bad about themselves for not having had enough sex.

    LUSE: Oh, yeah.

    SHERMAN: They still felt like it was an obligatory coming-of-age rite of passage to have sex, and so they felt quite ashamed about the fact that they had not yet managed to get laid, frankly.

    HESS: I haven’t studied this on a macro level. All I know is my own life.

    LUSE: Hey. Listen. Lived experience is valid.

    HESS: Exactly. But with that, I feel like I sort of got a ticket out of this sex recession of Gen Z because I’m queer. I’m now a gay man in my mid-20s in Brooklyn, which is, to say the least, not the most sex-negative milieu in America.

    LUSE: (Laughter) Fair.

    HESS: That being said, when I go online and I see the wider discourse, it feels just highly self-conscious and very fearful. And that does hearken back to some of my earlier experiences learning about sex. You know, I was in high school during the #MeToo era, then into college, and the anxiety surrounding sex was at a really, really stifling level.

    LUSE: We definitely are going to come back to that. Carter, what did you find? Are teens less horny, or is something else going on?

    SHERMAN: I would say that they are, in general, not less horny.

    LUSE: (Laughter).

    SHERMAN: I think what they are doing, though, is outsourcing a lot of their sexuality to the internet. They’re engaging in, like, watching a lot of porn. They’re engaging in LGBTQ+ communities online. And so I think that they are very interested in sex, but they’re not necessarily able to put it into practice as much. I mean, this is a generation that grew up during COVID, and so they missed a lot of key milestones. I talked to young people who, you know, weren’t able to go to graduation, weren’t able to go to prom, and these are the sort of things that create the space for young people to connect with one another, to be vulnerable with one another. And they just missed out on having that really critical IRL experience to know what it’s like to try and get with somebody else.

    LUSE: To that point around, like, COVID kind of changing the teenage experience or the different modes of teenage exploration, one of the things you mention in your book was changes in sex ed. Of course, we know it’s long been fear-based and abstinence-minded in some areas of the country. But you also found that during the pandemic, when teens were getting sex ed at home, some parents were around while sex ed was being taught and they didn’t like what they were hearing. And that kind of precipitated a wave of pushback on comprehensive sex ed in schools. And it’s also important to mention that Gen Z were probably, by and large, not having, you know, a ton of sex during lockdown when they otherwise might have if they weren’t, like, cooped up in the house with their families 24/7.

    SHERMAN: During COVID, what ended up happening is, yes, a lot of parents were seeing for the first time the kinds of sex ed that their children were getting. And a vocal minority became angry over things like comprehensive sex ed, which is the kind of sex ed that teaches about more than abstinence. It teaches about the diverse array of sexualities that exist. It teaches about things like condoms and preventing pregnancy and preventing STIs. And since then, there has been an explosion of debate in places like school boards, where people are arguing vehemently against expanding any kind of comprehensive sex ed. And I think what this does, overall, is really demonizes the very idea of sex. You have this simultaneous experience of not going through any of the things that you would see in teen movies while, at the same time, sex seems more political and more weighty. And you can see how that would dissuade people from engaging with it in a comprehensive way, in a way that prioritizes exploration and inclusivity.

    LUSE: Tobias, you brought up how the #MeToo movement was something that was looming very large when you were, you know, like, developing your sexuality as a young person. I wonder – like, how did things like the #MeToo movement and the rolling back of reproductive rights contribute to this kind of caution or very real fear around sex?

    HESS: I was a freshman in college in 2018, so really right after the height of the #MeToo movement and orientation around consent was really at its peak. And I think the tenor of discourse was so fraught and so scary that there was no sort of signal that sex was something that young people did for pleasure or for fun or to connect. It was, you know, all in terms of, this is what consent looks like. The kind of takeaway in terms of what we all understood about sex and consent is that, you know, consent is ongoing, it’s clearly affirmative and ambiguity is a danger zone. But the truth is, we often don’t know what we want or how we want it, and navigating through ambiguity, at least in my experience, is a part of sexuality. So I think that there was a diminishment in how to deal with your own, sort of, complex feelings about your own desire.

    LUSE: You know, it’s interesting. #MeToo, for me at least, was, like, very much connected to some of my own experiences at work. I’d been in the workforce for quite a while by the time #MeToo happened, and so I had racked up enough experiences where that was truly the context where I was thinking about it first and foremost. I really hadn’t imagined how a big cultural change like that might also kind of affect burgeoning sexuality.

    SHERMAN: I think your framing about #MeToo being about work is key to this because I think what potentially led to some of the backlash or the fault lines in #MeToo was this question of, is this about work or is this about sex? And I think for plenty of older people – I was already working by the time #MeToo broke out. I thought about it a lot in the context of work, and indeed the lasting legal reforms that we saw out of #MeToo dealt with work.

    LUSE: Right.

    SHERMAN: They were changing the laws around NDAs. They were introducing better HR trainings at work. But we did not see a commensurate change in the institutions that are tasked with dealing with sexual harassment and assault, particularly in schools and on college campuses. Title IX is the civil rights law that is meant to handle sex discrimination in schools, including harassment and assault. And what that law has become is basically a political football that one expert told me is, quote-unquote, “completely unusable” for survivors at this point. So what #MeToo did for younger people who thought about #MeToo, oftentimes in terms of sex, is it did generate so much anxiety around sex. It made so many of them realize that things that might have seemed like they were off were, in fact, wrong, that they were, in fact, harassment or assault, but it didn’t actually provide them with any resources to address that, to make it better, to seek accountability and justice and healing for themselves.

    So for the young women I talked to, I think they understood much earlier than I had that certain experiences they had had they deserve to be made whole from. They deserve to seek accountability, but they didn’t actually have the resources to do that. And that makes the whole world just seem so much more dangerous ’cause it just makes it seem like now you know that something bad happened, but no one else cares.

    LUSE: Like, where’s the recourse?

    SHERMAN: Exactly. For the overturning of Roe v. Wade, when I talk to young people, straight ones who were worried about getting pregnant or impregnating somebody else, they were petrified. And I think that that feeling that people are now going to face a kind of punishment for sex because they’ll be forced to have kids that they don’t want to do – I think that is really rife within Gen Z. And again, that contributes to this overall miasma of anxiety and fear around sex that really doesn’t lead people to want to have it.

    (SOUNDBITE OF MUSIC)

    LUSE: Coming up, how our digital culture and the state of our sex ed is changing how Gen Z learns about sex.

    SHERMAN: Learning how to have sex from porn is like learning how to drive by playing Grand Theft Auto.

    LUSE: Stick around.

    (SOUNDBITE OF MUSIC)

    LUSE: You know, I can imagine how, like, that might make, you know, Gen Z women and girls more reluctant to have sex – both of these big sort of, like, cultural and political, like, touchstones, like #MeToo and, you know, the rollback of Roe v. Wade. But – I don’t know – how are these shifts also affecting Gen Z men and boys as well?

    SHERMAN: One young man I spoke to about #MeToo – I really appreciated how straightforward he was about this. He said that he felt that the #MeToo movement, even though he supported it, could at times be very anti-cis male. And I think that this was a feeling that was common among some of the men I spoke to because they felt like this movement demonized them unfairly for something that they thought they hadn’t done. They felt like they were preemptively perceived as guilty.

    The other thing that I found really interesting about the reaction to #MeToo among young men is I don’t think it actually changed some of the things that contribute ultimately to sexual harassment and assault. One young man I spoke to was telling me about how in high school, he and his friends would rank the girls in their class on the basis of hotness. They’d do basically, like, football drafts. And that is dehumanizing.

    LUSE: Yeah.

    SHERMAN: You know, it’s not treating these women as whole people. And I was sort of trying to figure out a way to talk to him about this, to get him to open up about how he felt about doing that and if he felt it was a good thing. And he was saying, you know, you’re talking about #MeToo, and that’s about consent, but it’s not really about a person’s humanity. But they are connected, right? You respect somebody’s consent because you respect their humanity.

    LUSE: Yeah.

    SHERMAN: And so I don’t think that the fundamental connections about why consent is important or why we treat other people equitably were necessarily landed post-#MeToo.

    LUSE: That kind of sentiment – it feels so connected to kind of, like, a lot of the complaints that I feel like I see online or that I hear in discourse around this season of “Love Island USA,” around how, you know, young men relate to, you know, the young women that they want to date. It seems like you can’t kind of divorce dating standards and dating mores from this kind of, like, web of complex feelings around straight men’s sexuality and how they express that and their sexual behavior and what’s OK and what’s not OK. It seems like there have been a lot of young men who feel burned by that in some ways and almost, like, run in the opposite direction perhaps toward more red pill kind of incel stuff.

    HESS: I mean, I thank the powers that be every day that I’m gay because I sometimes think if I were a straight 25-year-old man, who would my role models be? Like, what would I be modeling my sort of behavior and affect around? You know, how would I approach women? I struggle to think of a sort of cultural figure who represents a positive, expansive form of masculinity. I mean, there’s been so much discourse about Hasan Piker versus Joe Rogan.

    LUSE: Right.

    SHERMAN: I think many of the people who are even talking about this, many of the male cultural figures who are even talking about this, are on the right.

    HESS: Yeah.

    SHERMAN: You know, Andrew Tate does talk about masculinity. Joe Rogan talks about masculinity. Jordan Peterson talks about masculinity. And if you’re a young man, a young straight man who is looking to understand why he feels this way, you are going to gravitate towards people who are talking about why you feel this way.

    HESS: Yeah. Recently, Andrew Schulz, the podcaster who’s the…

    LUSE: Yes.

    HESS: Yeah. He made a comment. He’s, like, you know, whenever they want to denigrate a movement, they call it the bros, so the podcast bros or the Bernie bros. It’s, like, bro and masculinity as kind of a way of diminishing, or it can be used in that way – tech bros. So I can totally understand if you’re a young man who identifies with listening to podcasts and you hear everyone describe you as a podcast bro as if that’s an insult, you’d be like, wait. Why are you backing me into a corner? I like podcasts. I like tech. I like Bernie Sanders. What’s wrong with that? So I think it becomes a problem.

    I also think that, you know, I understand the sentiment of, you know, cis straight men feeling, like, the implicit negativity around them, as I just discussed, when talking about sex and dating. But I also at the same time hear from my girlfriends about very casual dates that they have, where the men are acting totally, for lack of a better word, porny in a way that it just feels really, really icky. And, you know, spitting, choking, using, you know, verbal denigration – I’m not saying there’s anything wrong with any of those sexual acts, but they require a certain level of trust. And I’m hearing about first dates, spitting, choking, without clear communication. So I think there’s this dual experience of, you know, why is everyone against us? – and not having the tools to kind of act considerate.

    LUSE: You both gave such great answers to that question. I mean, this is something we’ve been turning over a lot on this show. A lot of people are kind of turning this over in culture. But you both gave really thoughtful responses to that question in a way that really highlights there’s lots of young men who want to be acknowledged also for being thinking and feeling whole people. But as you just have acknowledged, Tobias, we don’t really encourage young men or boys to kind of, like, gain the tools of consideration.

    But, you know, you brought up porn. Gen Zers are, quote-unquote, “digital natives,” like, you know, all grew up with the internet, and you don’t have to go very far to find porn on there. There’s this, like, totally different level of access and a totally different culture around pornography on the internet than there was, I think, in previous generations. How has our culture’s relationship to porn changed from previous generations, and how does that affect younger people?

    SHERMAN: I was very interested in reporting out this book to understand what porn has done, and also specifically what young people think porn has done to them. So the science on porn, I would say, is one of the great modern mysteries. We really don’t know from a scientific perspective how porn affects us.

    LUSE: Really?

    SHERMAN: And that’s in part because it’s impossible to find a control group. You cannot find young people who have not seen internet porn, so you can’t compare and contrast in that way. But what I found in interviews is that regardless of what is true scientifically, young people very much felt like porn had warped their relationship to sex. And this is what sociologists call the, quote-unquote, “deep story,” which is the story that people feel to be true. And that story can be more moving and impactful than the actual facts. And in particular around choking, young people very much felt like porn had normalized more, quote-unquote, “rough” sex. So if you are under 40, you’re almost twice as likely to have been choked than folks who are above 40. And a significant fraction of people say that they were not asked before they were choked, which – I agree with Tobias – if you’re into that, you go for it. But you definitely want to ask somebody before you choke them, not only because consent is obviously critical to any sexual encounter, but because choking in particular is strangulation. It is a more dangerous sexual act than other things that you can do.

    LUSE: Yeah.

    SHERMAN: I do think, though, that a lot of this discussion around pornography misses some of the nuances around what kinds of porn are out there. So many young women and many young queer people I talked to didn’t actually enjoy video porn so much, but they loved fan fiction and erotica and romance novels.

    LUSE: Right.

    SHERMAN: And they learned a lot about themselves through those forms of pornography, and they learned what made them feel good. And this is, I think, the ultimate point of what has gone on with internet porn, whether video or written, is that because we do not have quality sex ed available in many schools, young people have to turn to the internet to understand what sexual pleasure looks like, how they make other people feel good, what makes them feel good. And so we have basically elevated porn to being sex ed, even though I think most people would agree that is not what porn is for. Learning how to have sex from porn is like learning how to drive by playing Grand Theft Auto – lots of crashes.

    LUSE: Lots of crashes. Lots of crashes. What does all this say about how sexual culture has changed? And where do you see Gen Z’s sexlessness having cultural reverberations outside of online discourse?

    HESS: Well, sexlessness leads to probably resentment, as we’re seeing. You know, we’ve seen the rise of incel culture, which is a stand-in for just general sense of solitude and hopelessness among young men. There’s incels. There’s also femcels.

    LUSE: Yes. I’ve heard of femcels – girls and women who are celibate, either voluntarily or involuntarily. Yeah.

    HESS: Yes. I’m not an expert in either space, but I know that they’re around and, you know, are kind of the most extreme examples of this larger context that we’re living in and my generation is going through. So with that, I think the gender divide and the political gender divide will get more extreme as this kind of bears on and people and young people feel increased sort of alienation from each other, from their own sort of sexual selves.

    SHERMAN: I think we’ve already seen a political harnessing of the narrative that Gen Zers are sexless. We’ve seen talk from the Trump administration about wanting to raise the birth rate, for example. And so it’s impossible to disentangle that pronatalist impulse from this idea that young people are not having enough sex. I think the narrative of the sex recession is being used to basically say – by the right – oh, gender roles have irretrievably broken down. The American family is in chaos. We need to reinstate a more hierarchical sexual order where we prioritize or even compel people into sex that is straight, that is married and that is potentially procreative because it’s being practiced without access to abortion or access to hormonal birth control.

    LUSE: I’ve learned so much here. Thank you.

    SHERMAN: Thank you.

    HESS: Thank you. This has been great.

    LUSE: That was Tobias Hess, contributing writer at Paper Magazine and writer of the Gen Zero Substack, and Carter Sherman, reproductive health and justice reporter at The Guardian and author of “The Second Coming: Sex And The Next Generation’s Fight Over Its Future.”

    And I’m going to put on my influencer hat for a second and ask you to please subscribe to this show on Spotify, Apple or wherever you’re listening. Click follow so you know the latest in culture while it’s still hot.

    This episode of IT’S BEEN A MINUTE was produced by…

    LIAM MCBAIN, BYLINE: Liam McBain.

    LUSE: This episode was edited by…

    NEENA PATHAK, BYLINE: Neena Pathak.

    LUSE: Our supervising producer is…

    BARTON GIRDWOOD, BYLINE: Barton Girdwood.

    LUSE: Our executive producer is…

    VERALYN WILLIAMS, BYLINE: Veralyn Williams.

    LUSE: Our VP of programming is…

    YOLANDA SANGWENI, BYLINE: Yolanda Sangweni.

    LUSE: All right. That’s all for this episode of IT’S BEEN A MINUTE from NPR. I’m Brittany Luse. Talk soon.

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    Copyright © 2025 NPR. All rights reserved. Visit our website terms of use and permissions pages at www.npr.org for further information.

    Accuracy and availability of NPR transcripts may vary. Transcript text may be revised to correct errors or match updates to audio. Audio on npr.org may be edited after its original broadcast or publication. The authoritative record of NPR’s programming is the audio record.

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  • The Best Summer Weddings Published in Vogue

    The Best Summer Weddings Published in Vogue

    Ah, the classic summer wedding. Historically, it’s always been the most popular season to get married, in part due to the warm weather and abundance of greenery. And every year, Vogue publishes a number of idyllic nuptials that take place from June through early September.

    Sometimes those are in perennial American vacation spots like Nantucket or The Hamptons; other times, they’re abroad in European hotspots like St. Tropez or Capri. There are those held at family homes, and those held at iconic hotels. Many couples embrace a traditional aesthetic with white lace dresses and hydrangeas, while others prefer to break the mold—like one couple who held a minimalist wedding in Greece, with a dress code inspired by Calvin Klein ads from the ’90s. Yet all of them have the same thing in common: embracing the outdoors, sunshine, and natural scenery.

    Below, find 19 of our favorite summer weddings in Vogue. It’s in no way a complete list… in fact, we have a feeling we’ll be adding to it very soon.

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  • Live Aid concert was ‘one of the highlights of my life’

    Live Aid concert was ‘one of the highlights of my life’

    Matt Shepherd

    BBC News Cornwall

    Julia Gregory

    BBC News South West

    Matt Shepherd/BBC A man with a white beard and glasses is standing in a gallery with a range of different paintings in a variety of styles. Some show bright red and green circles in front of a bright green background. His polo shirt has the logo Market House.Matt Shepherd/BBC

    Paul Jennings was in the crowd at Wembley for Live Aid 40 years ago

    A man who was among the 72,000-strong crowd at the groundbreaking Live Aid concert in 1985, has said it was “one of the highlights of my life”, on the 40th anniversary of the event.

    Paul Jennings, from St Austell, managed to secure one of the much sought after tickets to the day-long festival at Wembley Stadium on 13 July 1985, which was organised to raise money for famine relief in Ethiopia.

    Paul McCartney, David Bowie, Madonna and Mick Jagger were among the performers at the concert that raised £150m.

    “It was absolutely magic. You kept on seeing the stars reported in the press. This star’s coming, that star’s coming. You just didn’t expect to get 20 to 30 groups together,” said Mr Jennings.

    PA Bono, Paul McCartney and Freddie Mercury are all singing on a stage, with the word Live just seen behind them.
Paul McCartney has dark hair and a black top and is singing into a microphone held by Bono, who wears a dark jacket. Freddie Mercury from Queen is to their right. He has a red singlet on, short cropped dark hair and has a dark moustache.PA

    Bono, Paul McCartney and Freddie Mercury were among the stars who performed at Live Aid

    The concert was organised by Boomtown Rats singer Bob Geldof and Ultravox singer Midge Ure.

    It was seen by an estimated two billion people in more than 100 countries with simultaneous concerts in London and Philadelphia in the US and followed on from the Band Aid single Do They Know It’s Christmas?

    Status Quo started the show with Rocking all over the World and there were also performances from Tina Turner, U2, Elvis Costello, Howard Jones, Roger Daltrey, Spandau Ballet, Sting, and The Style Council.

    PA Freddie Mercury has short dark cropped hair and a black moustache and is wearing a white singlet and holding a microphone as he looks out towards the audience.PA

    Mr Jennings said Queen’s Freddie Mercury stole the show at Live Aid

    “What a way to start,” said Mr Jennings, who was working for a London computer company at the time.

    He said Queen’s Freddie Mercury stole the show and “just stood out 200% above everybody else”.

    “It was hairs on the back of your neck, a real buzz,” Mr Jennings added, referring to when he joined the crowd singing with the Queen star when he led the ay-oh call and response.

    “It was just an outstanding performance, the amazing voice he had.”

    ‘Struggling to survive’

    Mr Jennings, who is now a director of the Market House in St Austell, said the concert was “one of the highlights of my life”.

    He had visited east Africa and seen “how people were living” and then saw news reports of “how it had descended into a total dustbowl and you had thousands of people struggling to survive”.

    “We all felt we’ve got to do something, even if it’s just buying a ticket to a concert. It was ‘we’ve got to do something’,” he said.

    Live Aid: Cornish memories forty years on

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  • FDA Reviews All-Oral Decitabine/Cedazuridine/Venetoclax Combo in AML

    FDA Reviews All-Oral Decitabine/Cedazuridine/Venetoclax Combo in AML

    • The FDA has accepted the supplemental new drug application (sNDA) for decitabine and cedazuridine (Inqovi) plus venetoclax (Venclexta) in newly diagnosed patients with acute myeloid leukemia (AML) ineligible for intensive chemotherapy.
    • The phase 2b ASCERTAIN-V trial (NCT04975919) showed a 46.5% complete response (CR) rate and 15.5-month median overall survival (OS).
    • This is the first potential all-oral regimen in this setting, with no new safety concerns reported.

    The FDA has accepted the sNDA of decitabine and cedazuridine plus venetoclax for the treatment of patients with newly diagnosed AML who are ineligible for intensive induction chemotherapy.1

    The sNDA is supported by data from the phase 2b ASCERTAIN-V trial, which evaluated decitabine/cedazuridine plus venetoclax in 101 adults with newly diagnosed AML who were deemed unfit for intensive therapy. The trial achieved its primary end point with a CR rate of 46.5% (95% CI, 36.5%-56.7%) and showed a CR or CR with incomplete hematologic recovery (CR + CRi) rate of 63.4% (95% CI, 53.2%-72.7%).

    The median OS was 15.5 months, and at 12 months, the median duration of response (DOR) had not yet been reached. Importantly, over 75% of patients who achieved a CR remained in remission at 1 year.

    “If approved for patients with AML who are not eligible to undergo intensive induction chemotherapy, [decitabine/cedazuridine] in combination with venetoclax would offer the first all-oral alternative to current therapies,” said Harold Keer, MD, PhD, chief medical officer of Taiho Oncology, in a press release.

    White blood cells in leukemia – stock.adobe.com

    Patients in the ASCERTAIN-V trial received decitabine/cedazuridine orally on days 1 through 5 of a 28-day cycle along with daily oral venetoclax, reflecting a regimen that could be administered in an outpatient setting. The median follow-up in the study was 11.2 months. These results were first presented at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting and further highlighted at the 2025 European Hematology Association (EHA) Congress.

    The combination demonstrated a manageable safety profile with no new safety concerns. Grade 3 or higher adverse events (AEs) were reported in 98% of patients, consistent with expectations in this high-risk population. The most common AEs included febrile neutropenia (49.5%), anemia (38.6%), and neutropenia (35.6%). Early mortality was relatively low: deaths within 30 days of treatment initiation were observed in 3% of patients and 9.9% by 60 days, due to either AEs or disease progression. Importantly, no drug-drug interactions were observed between decitabine/cedazuridine and venetoclax.

    Decitabine with cedazuridine is already FDA-approved for the treatment of myelodysplastic syndromes (MDS) and chronic myelomonocytic leukemia (CMML). It is the only oral hypomethylating agent approved for adults with intermediate- and high-risk MDS, offering convenience over traditional intravenous options such as decitabine or azacitidine.

    The FDA has granted the sNDA application a standard review with a Prescription Drug User Fee Act action date of February 25, 2026. If approved, the regimen will offer oncologists a novel, simplified option to manage newly diagnosed patients with AML who cannot tolerate intensive treatment. As more data emerge and real-world application expands, decitabine and cedazuridine plus venetoclax could redefine frontline care for a population long underserved by existing regimens.

    REFERENCES:
    1. Taiho Oncology and Taiho Pharmaceutical announce U.S. FDA acceptance of supplemental new drug application for INQOVI® in combination with venetoclax to treat patients with acute myeloid leukemia. News release. Taiho Oncology, Inc., and Taiho Pharmaceutical Co., Ltd. July 9, 2025. Accessed July 10, 2025. https://tinyurl.com/tc8svj6d
    2. Roboz GJ, Zeidan AM, Mannis GN, et al. All-oral decitabine-cedazuridine (DEC-C) + venetoclax (VEN) in patients with newly diagnosed acute myeloid leukemia (AML) ineligible for induction chemotherapy: phase 1/2 clinical trial results. Presented at: European Hematology Association Congress; June 12-15, 2025; Milan, Italy. Abstract S135.

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  • OpenAI Is Reportedly Launching AI Browser to Rival Chrome – TechRepublic

    1. OpenAI Is Reportedly Launching AI Browser to Rival Chrome  TechRepublic
    2. Exclusive: OpenAI to release web browser in challenge to Google Chrome  Reuters
    3. Perplexity launches Comet, an AI-powered web browser  TechCrunch
    4. ‘Hypocrisy’ will not continue, Iran tells IAEA  The Business Standard
    5. OpenAI and Perplexity to challenge Google Chrome with AI web browsers  Music Ally

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