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  • Unprivileged to get legal aid at state expense – Pakistan

    Unprivileged to get legal aid at state expense – Pakistan

    ISLAMABAD: Chief Justice of Pakistan Yahya Afridi on Monday anno­unced a new initiative for underprivileged litigants to engage legal representation, at state expense.

    The initiative, launched under the auspices of the Law and Justice Commi­ssion of Pakistan (LJCP), will be implemented acr­oss all levels of the judiciary, from magistrate courts to the Supreme Court.

    The counsels in such cases would be given up to Rs50,000 in remuneration, which would be provided to them through the Dis­trict Legal Empo­werment Commi­ttees, to ensure equi­table access to justice for all citizens.

    The decision was taken during a meeting presided over by the chief justice at the Supreme Court Branch Registry in Quetta. The meeting reviewed institutional linkages between the bar associations of Balo­c­histan and LJCP in strengthening justice delivery.

    During the meeting, the CJP shared insights from his visits to some remote districts, where he noticed a gap in coordination bet­ween bar associations and the LJCP. He said that despite the availability of funds, they were not being properly utilised for uplifting the district judiciary.

    As the commission has limited outreach capacity, LJCP has decided to post a senior-level representative in every province who will be stationed at the respective high courts. These representatives will act as front desk to maintain liaison with district bar associations, identify local priority areas, raise awareness, and supervise grassroots-level justice sector initiatives.

    The bars associations may present their development project proposals to District Development Committees. Moreover, representatives of federal and provincial development departments have also been taken on board to ensure speedy execution and to avoid resource duplication.

    Moreover, CJP encouraged the bar representatives to ensure that their members benefit from the Continuing Legal Education programmes offered by the Federal Judicial Academy.

    Balochistan High Court Bar Association President Attaullah Khan Langov apprised the meeting about various facilities provided by the provincial government to the bar associations across the province.

    It included 100 scooties for women lawyers, digital library at High Court Bar, shuttle services from high court to District Court Quetta, a 100-acre housing scheme for lawyers of high court and grant-in-aid by the federal government to 28 districts bars of Balochistan and the High Court Bar Association.

    All federal and provincial stakeholders present at the meeting assured their full cooperation and support in advancing the shared goal of accessible and efficient justice.

    Published in Dawn, July 15th, 2025

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  • Over 78 Palestinians martyred in Israeli attacks across Gaza – RADIO PAKISTAN

    1. Over 78 Palestinians martyred in Israeli attacks across Gaza  RADIO PAKISTAN
    2. LIVE: Israel kills dozens as it bombards Gaza, Lebanon and Syria  Al Jazeera
    3. Three people killed in Tuffah neighbourhood  Dawn
    4. Gaza father’s outrage after Israeli strike kills son ‘searching for sip’ at water point  BBC
    5. Statement by UNICEF Executive Director Catherine Russell on children killed during a nutrition aid distribution in the Gaza Strip  Unicef

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  • Nvidia gets nod from Washington to resume sales of H20 China chip – Financial Times

    Nvidia gets nod from Washington to resume sales of H20 China chip – Financial Times

    1. Nvidia gets nod from Washington to resume sales of H20 China chip  Financial Times
    2. Nvidia’s Jensen Huang plans Beijing trip ahead of new China AI chip launch  Financial Times
    3. China Wants to Use 115,000 Banned Nvidia Chips to Fulfil Its AI Ambitions (NVDA)  Bloomberg
    4. China aims to deploy 115,000 Nvidia AI GPUs: Report  RCR Wireless News
    5. Nvidia says U.S. government will allow it to resume H20 AI chip sales to China  CNBC

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  • Hubble Cracks Open a Glittering Cosmic Time Capsule, Revealing Multi-Generational Stars 160,000 Light-Years Away

    Hubble Cracks Open a Glittering Cosmic Time Capsule, Revealing Multi-Generational Stars 160,000 Light-Years Away

    For this ESA/Hubble Picture of the Week, we gaze upon the field of stars that is NGC 1786. This object is a globular cluster in the Large Magellanic Cloud (LMC), a small satellite galaxy of the Milky Way Galaxy that is approximately 160,000 light-years away from Earth. NGC 1786 itself is in the constellation Dorado. It was discovered in the year 1835 by John Herschel.

    The data for this image comes from an observing program comparing old globular clusters in nearby dwarf galaxies — the LMC, the Small Magellanic Cloud and the Fornax dwarf spheroidal galaxy — to the globular clusters in the Milky Way galaxy. Our galaxy contains over 150 of these old, spherical collections of tightly-bound stars, which have been studied in depth — especially with Hubble Space Telescope images like this one, which show them in previously-unattainable detail. Being very stable and long-lived, they act as galactic time capsules, preserving stars from the earliest stages of a galaxy’s formation.

    Astronomers once thought that the stars in a globular cluster all formed together at about the same time, but study of the old globular clusters in our galaxy has uncovered multiple populations of stars with different ages. In order to use globular clusters as historical markers, we must understand how they form and where these stars of varying ages come from. This observing programme examined old globular clusters like NGC 1786 in these external galaxies to see if they, too, contain multiple populations of stars. This research can tell us more not only about how the LMC was originally formed, but the Milky Way Galaxy, too.

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  • WWE Raw results, highlights (July 14): Seth Rollins injury update, Roman Reigns returns

    WWE Raw results, highlights (July 14): Seth Rollins injury update, Roman Reigns returns

    The “WWE Raw” after WWE Evolution did a perfect job of adding even more to the overall spectacle of Sunday night’s event. Birmingham, Alabama was treated to a show centered mainly around the fallout from the PLE, and it was all seamless. Despite that, there was still a bigger, overarching matter to address from WWE’s weekend — plus one significant return.

    The Seth Rollins dilemma

    As Paul Heyman first spoke tonight, I hatched the outline of where to go in the wake of Rollins’ injury absence.

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    Heyman noted how it’s too early to know any real updates on Rollins’ timeline, mentioning he has until June to cash in. So, that leads one to believe it’s staying with him — for now. I’m not in love with the idea, since it means there will be a gap of early months where we know there can’t be a surprise return. But what followed was the seed to a tangible direction.

    Bron Breakker was hyped up by his “Oracle” to become the next World Heavyweight Champion. Imagine that. Breakker does win it while Rollins is away and eventually gets cashed in on by his recruiter. Vintage Rollins.

    Well, the “WWE Raw” main event contender gauntlet match resulted in a CM Punk win. So, you know what that means. Punk is winning that title, and Rollins cashes in on him instead.

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    The matches within the match were mostly pretty good, but the booking of this was atrocious, and you could feel the scrambled fallout of Rollins’ injury.

    First and foremost, Gunther cut a promo beforehand that led to him staring down Breakker with Heyman hyping up a match between them. That felt like all the spoiler needed, but the swerve was admittedly a nice touch.

    To start things off, it was Breakker vs. Penta, which was essentially a copy and paste of the last time they wrestled.

    LA Knight followed, and he put on a show with Breakker. It really was the best mini-match in the heart of this — then Knight just lost clean to a single spear, killing all of the momentum he had built before WWE Saturday Night’s Main Event. It was practically a burial despite him seemingly building to some big spot with that Rollins match. Brutal stuff, and that was that. He was gone from the show after taking the L.

    Now, here was the biggest problem with all of this. During Knight’s portion of the match, Michael Cole stated on commentary that there were no disqualifications, which is news to me for this match type. Regardless, that makes zero sense when these are one-on-ones. And if that was the case, WWE could have at least booked Knight to lose with the aid of Bronson Reed — or have him come back after his loss to cost Breakker. Instead, Reed helped stop Jey Uso from beating Breakker. You know. To keep him somewhat “strong.”

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    If that wasn’t stupid enough, Reed then just didn’t attack CM Punk as soon as Punk arrived to take on Breakker. WHY NOT?!

    The logic in non-decisions like that has been so off with the “Sethriders” and their story beats. Reed ultimately got in there at the end, and rather than Knight, it was Uso who returned to help fend off the big men and secure Punk’s win with a GTS.

    There was still one surprise left after that, as Breakker and Reed took over and set up a sandwich Tsunami to Uso and Punk. Nope! It still wasn’t Knight. Roman Reigns returned to clean up shop, helping his old Bloodline stablemate and WrestleMania 41 rival.

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    Reigns’ return certainly adds a massive wrinkle to the title picture, and is somewhat of a Hail Mary move with Rollins out. But hey, he certainly felt needed now more than ever.

    Proceeding with caution

    “WWE Raw” kicked off with quite the epic opener to immediately follow the incredible momentum from last night’s WWE Evolution 2025 PLE. The brand new Women’s World Champion Naomi set the stage and received a huge ovation, along with “You deserve it” chants. It was great to see, especially with Naomi remaining in character and shutting it down, but playfully.

    The champ called out everyone for not “feeling the glow” and guessing wrong that she’d cash in on Tiffany Stratton. Bianca Belair then got her shot, as Naomi said she outgrew her, which keeps the roots planted for their eventual massive showdown.

    Before her first interruption, Naomi dropped…

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    🤯 Line of the Year

    THE WOMAN TOLD ALL THE “RAGGEDY HEFFAS” ON “WWE RAW” TO WATCH OUT.

    Brothers and sisters, I lost my marbles when she said that. Incredible. It’s a damn shame that WWE didn’t let Naomi reach a character arc like this sooner.

    Rusev delivered a good contender later, saying he wants “gold, not gingers” to Sheamus. What was in the water tonight?

    Anyway, a proper-pissed Rhea Ripley waltzed her way out to confront Naomi after ruining her chance at earning a win over Iyo Sky. That prompted the latter also to emerge before Naomi told both to get to the back of the line. Tensions started to thicken, and “WWE Raw” general manager Adam Pearce came out to make a triple-threat match for the title official at WWE SummerSlam.

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    So, I love that from a pure match perspective, and it feels appropriate. Storywise, not so much, especially for SummerSlam. The first defense for Naomi would have been best fit for, oh, I don’t know, this episode of “WWE Raw.” Just a thought, Hunter.

    Presumably, Bianca Belair may not be ready to return that soon because a Naomi match would be a great starting point in this reign. However, you have to expect it to end at WWE SummerSlam because there’s no way Stephanie Vaquer doesn’t challenge a champion Ripley in her title shot at Clash At Paris.

    Remember the 2-out-of-3 falls experiment?

    Whenever there’s a 2-out-of-3 falls match, I’m always going to think about that time Vince McMahon wanted to completely — and randomly — change the entire formula of WWE matches. On this “WWE Raw,” it was Bayley vs. Lyra Valkyria.

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    Alright. This match was for a title shot against Becky Lynch at WWE SummerSlam. I get it. We’re supposed to get to Valkyria’s trilogy match, but this doesn’t make sense after they both just lost at WWE Evolution. Additionally, it’s now at the point where the Intercontinental title scene has been exclusively limited to these three wrestlers. No one else has even mentioned or looked at the title since before WrestleMania 41. And the last person who did was Bayley! You have to spread the love soon, Triple H. Seriously.

    Realistically, I can’t be that mad because this was easily the…

    👑 Uncrowned Gem of the Night 👑

    Valkyria and Bayley freaking rule together. This match started with Bayley working over Valkyria’s back before the tight roll-up for her lone pin. Valkyria scored her first with a lovely counter pin.

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    We saw tons of phenomenal spots like Valkyria’s sit-out gut-wrench powerbomb, the sunset flip into the steps and the finishing sequence when Bayley dropped the elbow onto Valkyria’s back and got a near-fall. It went into a crossface that Valkyria countered into a Nightwing. Brilliant. Just brilliant. These three are delivering some of the best overall work in wrestling right now. This two-day punch of action has been insane.

    👍 MONDAY NIGHT MONEY 👍

    1. This “WWE Raw” started with three women’s matches, further displaying that this can just be done normally. There doesn’t have to be a big women’s-only show to highlight all these great wrestlers. Regardless, it was refreshing to see, and the route to take right after WWE Evolution.

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    2. Karrion Kross received a video promo that continued to target Sami Zayn. I think everyone probably couldn’t care less about the Zayn aspect of this. It was just wonderful to see a good promotional piece for Kross that wasn’t during a commercial break.

    3. Rusev and Sheamus will run it back at some point. Usually, I’d be a little on the fence about this, but these guys just have that chemistry. Let them wrestle 80 times for all I care.

    🤷 IT HAPPENED 🤷

    The Judgment Day (Raquel Rodriguez and Roxanne Perez) defeated The Kabuki Warriors when Perez rolled up Asuka. It was an OK match, and nothing more than a story speed bump, with Dominick Mysterio helping his faction get the win by distracting the referee. A typical Judgment Day “meh.”

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    👎 RAW DEAL 👎

    1. Nikki Bella defeated Chelsea Green. It was not good. Green losing isn’t great either. This seemed to set up a brief team of Bella and Vaquer, as she made the save after the match when Green and The Secret Hervice attacked.

    2. Pearce tells The New Day he doesn’t just hand out title rematches — after literally doing so earlier in the night for Sky and Ripley.

    👑This was a jam-packed “WWE Raw” and the kind of show you’d hope for after a big weekend. I give this show a Crown score of: 7.5/10.👑

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  • New autoimmune target identified in pediatric idiopathic nephrotic syndrome

    New autoimmune target identified in pediatric idiopathic nephrotic syndrome

    Idiopathic nephrotic syndrome (INS) is a serious kidney disease in children with no clear cause. In a recent study, researchers have identified a novel autoantibody targeting vinculin—a protein crucial for kidney cell structure—as a significant factor in INS. The study found that these autoantibodies are present during active diseases and decline when symptoms subside, suggesting potential for diagnosis and disease monitoring. Mouse models were further used to validate these findings.

    Idiopathic nephrotic syndrome (INS), particularly prevalent in children, is a kidney disorder marked by severe protein loss in the urine and low blood protein (albumin) levels. Growing body of research has shown that autoantibodies, or antibodies produced by the immune system that mistakenly target the body’s own cells and proteins against podocytes may play a role in INS, but the precise underlying mechanisms remain elusive.

    Now, however, a study by researchers from Zhejiang University, China, sheds light on this mystery by identifying a previously unrecognized immune factor: autoantibodies targeting vinculin, a key structural protein present in kidney cells. Their findings were published online in Research on June 3, 2025. The research team was led by Dr. Hanyan Meng from the Department of Nephrology, Children’s Hospital, Zhejiang University School of Medicine, China, sought to investigate the pathogenic role and underlying mechanisms of anti-vinculin autoantibodies in INS.

    What exactly is vinculin, and why does it matter in kidney health? Vinculin is a protein that plays an important role in cell adhesion and cell mobility. These proteins are particularly found in podocytes and critical for podocyte cytoskeletal integrity. Anti-vinculin autoantibodies—the body’s own antibodies that attack vinculin—can cause damage to the kidney’s filtering cells.

    By analyzing serum samples from across 147 children with INS, the researchers discovered significantly elevated levels of anti-vinculin autoantibodies compared to healthy and disease control groups.

    These antibodies were present in over half of the INS patients and closely correlated with the clinical markers of disease severity, including cholesterol levels and protein in urine.”


    Dr. Hanyan Meng from the Department of Nephrology, Children’s Hospital, Zhejiang University School of Medicine, China

    Notably, the antibody levels dropped as the children recovered, and over half of them no longer had these antibodies once their symptoms subsided. The team further conducted a series of experiments using mouse models to understand causality. When injected with anti-vinculin antibodies or when actively immunized with recombinant vinculin protein, the mice developed hallmark features of INS, including proteinuria (high levels of protein in urine) and cell injury, which were confirmed via immunofluorescence and electron microscopy.

    Transcriptomic analysis of kidney tissue from these mice revealed an increased activation of genes associated with inflammation, B cell activation, and immune signaling, alongside downregulation of cytoskeletal genes. This suggests that anti-vinculin antibodies may not only damage podocytes directly but also activate a broader immune response that worsens the disease.

    “These findings provide compelling evidence that anti-vinculin autoantibodies are not merely markers but active drivers of disease,” highlights Dr. Meng. “They could serve as dynamic biomarkers for early diagnosis, treatment monitoring, and risk stratification in pediatric nephrotic syndrome.”

    These findings add up to our understanding of INS and contribute to a growing body of work suggesting that various autoantibodies—against nephrin, Crb2, podocin, and other proteins found in the kidney’s filtering units—may underlie different forms of kidney disease. Since vinculin is a critical structural protein in podocytes, its disruption by autoantibodies leads to loss of structural integrity and breakdown of the kidney’s filtration barrier.

    From a clinical perspective, the identification of anti-vinculin autoantibodies represents a significant step toward precision medicine for children with INS. While most pediatric patients respond well to steroids, a significant portion develops steroid resistance and doesn’t respond well. The current study found that anti-vinculin antibodies were more prevalent in patients with steroid-resistant nephrotic syndrome (SRNS), suggesting their potential role in guiding treatment strategies.

    “By adding antibody screening into routine clinical assessment, we may be able to reduce the need for invasive kidney biopsies and tailor better therapies to individual patients,” adds Dr. Meng.

    While the study holds significance, the authors acknowledge its limitations, calling for larger, multicenter studies to confirm the diagnostic value of anti-vinculin antibodies. In the future, their research will focus on how these autoantibodies are generated and how they access intracellular targets like vinculin, building on the understanding of INS and better strategies to overcome the disease.

    Source:

    Journal reference:

    Meng, H., et al. (2025). Autoantibodies Targeting Vinculin Reveal Novel Insight into the Mechanisms of Autoimmune Podocytopathies. Research. doi.org/10.34133/research.0722.

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  • Automated tax filing system rolled out for salaried class – Pakistan

    Automated tax filing system rolled out for salaried class – Pakistan

    • Urdu version to be available by July-end, Sindhi and Pashto versions will follow suit
    • New system will automatically pull data linked to filer’s CNIC, at-source deductions, bank details
    • PM seeks early release of income tax refunds for salaried individuals; wants Raast chairman, board to be appointed by September

    ISLAMABAD: In a move to simplify tax filing procedures for the salaried class, the Federal Board of Revenue (FBR) has introduced a new interactive return form, which will incorporate an auto-fill system that seamlessly integrates data about purchases, asset details and tax deductions at source etc. — ultimately generating a single-form return upon completion.

    The new return form is currently available in English, while the Urdu version is set to come out by the end of this month.

    During the first rollout phase, the form will also be available in two regional languages, Sindhi and Pashto. More versions in regional languages — Punjabi and Balochi — are expected to be rolled out subsequently.

    Under the Income Tax Ordinance, individual taxpayers are required to file their returns by September 30.

    The new return form consists of eight digital windows, each containing one input column. The process is designed to be step-by-step, with each screen containing a single question prompt to guide users through the filing process.

    In the first window, entering one’s employer’s name will automatically populate the fields of tax deduction at source.

    All deductions of withholding taxes based on the Computerised National Identity Card (CNIC) numbers will also appear on the form.

    Similarly, providing bank account details will prompt the form to display closing balances.

    Registered purchases linked to the filer’s CNIC will also appear automatically, streamlining data entry and minimising manual input.

    According to an official annou­ncement, Prime Minister Shehbaz Sharif directed the FBR to launch a digital invoicing in Urdu. He said tax reforms should focus on facilitating citizens.

    He asked the FBR to expedite the release of income tax refunds for salaried individuals of those amounting to less than Rs50,000. These refunds are to be issued within one month of return submission. The total disbursement under this directive is estimated at Rs10 billion.

    While chairing a meeting to review progress on FBR reforms on Monday, the PM instructed the FBR to establish a helpline aimed at assisting the filing process. The meeting was informed that simplified digital tax returns for salaried individuals would be available from Tuesday, with access for other taxpayers beginning by July 30.

    PM Shehbaz said tax returns had been made digital, concise, and linked with a central database for public convenience. He believed the salaried class would benefit the most from the new simplified tax returns system. He noted that implementation of AI-based tax assessment system was a major success, calling for raising awareness to encourage taxpayers to use the new system.

    He also emphasized a third-party validation to ensure transparency in all FBR reforms. The premier directed the officials concerned to provide special facilities to small and medium-sized businesses to join the digital invoicing system.

    The meeting was briefed on progress regarding digital invoicing, e-Bilty, simplified tax returns, the AI-based assessment system, the central command and control centre, and the cargo-tracking system. It was shared that FBR’s Command and Control Unit would become operational by September, enabling centralized data access and facilitating efficient decision-making.

    Regarding the digital invoicing system, it was noted that all small and large businesses would issue receipts through FBR’s online platform at the point of sale and purchase. Approximately 20,000 businesses are expected to be integrated into the system in the coming months.

    Customs automation

    The meeting was briefed on the AI-driven assessment system that would allow traders to submit advance goods declarations prior to the arrival of ships, with full exemption from upfront duties and taxes. This measure is expected to increase advance declarations from three per cent to over 95pc, allowing containers to be transported directly from ships to factories.

    The meeting was informed that within just one month, 8,000 invoices worth Rs11.6bn were issued. The system includes a taxpayer portal and a monitoring dashboard. Integration with PRAL is free of cost, and traders’ training is being actively facilitated. Once fully implemented, traders will no longer need to file separate sales tax returns, as transactions would be automatically recorded in the system.

    Digital economy

    The PM said the digitisation of the economy was the government’s top priority as it would bring transparency to the system. He said that digitalising payment systems between the public and the government would enhance transparency and ease of use for citizens.

    He directed that progress towards a digital economy be accelerated and instructed that the processes of digitisation and the shift towards a cashless economy be simplified for small and medium-sized enterprises (SMEs). He also emphasised that all state-owned enterprises should be integrated into the digital framework.

    The PM advised the relevant officials to complete the process for the appointments of the board of governors and chairman of Raast by September. He noted that RAAST’s Board of Directors must comprise business experts.

    The meeting was informed that the number of users of mobile apps and digital banking services was expected to increase from 95 million to 120m, with the volume of digital payments projected to rise from Rs7.5bn to Rs15bn. A nationwide public awareness campaign on Raast and digital payments would be launched next month.

    To align Pakistan’s economy with those of developed nations, a Digital Payments Index will be introduced within one month. Additionally, the Capital Development Authority Board has approved the right of way for digital public infrastructure in Islamabad.

    It was also noted that the remittance system was being digitised, ensuring that all funds sent from abroad would be received through the formal banking system. Coordination is ongoing with the governments of all four provinces, Gilgit-Baltistan, and Azad Jammu and Kashmir to promote digital payments.

    Published in Dawn, July 15th, 2025

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  • Stocks Rise After Nvidia License, China GDP Beats: Markets Wrap

    Stocks Rise After Nvidia License, China GDP Beats: Markets Wrap

    (Bloomberg) — Asian stocks rose along with US equity-index futures after Nvidia Corp.’s plan to resume sales of its H20 AI accelerator to China boosted optimism that trade tensions between the world’s two largest economies are waning.

    The MSCI Asia Pacific Index erased earlier losses to gain 0.2% while contracts for the S&P 500 and the Nasdaq 100 edged up. A gauge of technology stocks rose as much as 2% in Hong Kong. Shares in mainland China fluctuated as the country’s second-quarter gross domestic product beat estimates. Bitcoin slipped below $120,000. Japan’s 10-year government bond yield climbed to its highest level since 2008 amid concerns about fiscal spending. 

    Nvidia plans to resume sales of its H20 artificial intelligence accelerator to China based on assurances from Washington that such shipments would be approved, a dramatic reversal from the earlier stance of President Donald Trump’s administration. US government officials have told Nvidia that they would green-light export licenses for the H20, the company said.

    The news is “obviously positive, not just for the company, but also the AI semiconductor supply chain, as well as China tech platforms that are building AI capabilities,” said Vey-Sern Ling, managing director of Union Bancaire Privee. “This is also a good development for US-China relations.”

    Stocks globally have rallied from their slump in April, when wide-ranging tariffs were announced, to record high levels as investors speculate the levies won’t significantly harm the US economy and company earnings, which kick off this week. That optimism faces a key test Tuesday as investors read the US inflation print, which will give investors clues on the impact from Trump’s tariffs and the direction for interest rates.

    “Markets have been much more resilient than what we anticipated at the start of the year,” Vikas Pershad, Asian equities portfolio manager at M&G Investments, said in a Bloomberg TV interview. “We also are subject to this crisis fatigue that seems to have set in across market.”

    Meanwhile, China’s economic growth exceeded expectations in the second quarter, but strong exports to markets outside the US masked deepening pressure caused by weak consumer demand at home.

    The GDP print is coming out after data showed China ended the first half of the year with a record trade surplus of about $586 billion as exports to the US began to stabilize, with factories riding out the tariff rollercoaster that upended global commerce.

    June home prices data bolstered the case for the government to take more measures to revive the property market.

    In the US, traders are gearing up for results from big banks and inflation data. While corporate America is bracing for its weakest earnings season since mid-2023, lower estimates could be easier for companies to beat. As US financial giants kick off earnings season Tuesday, strategists say subdued profit expectations are setting the stage for their sizzling run to continue.

    After months of seeing little inflation, the CPI probably experienced slightly faster growth in June as companies started to pass along higher costs of imported merchandise associated with tariffs.

    The options market is betting the S&P 500 will swing 0.6% in either direction after Tuesday’s CPI, based on the cost of at-the-money puts and calls, according to Citigroup Inc. That would be in-line with implied moves the past two months, though below an average realized swing of 0.9% over the last year.

    “Earnings growth is slowing, tariffs are starting to bite, and geopolitical risk remains elevated. Yet, stock valuations reflect a lot of optimism,” said Jeff Buchbinder and Adam Turnquist, strategists at LPL Financial, in a note Monday. “While trade uncertainty should start to dissipate in the second half, the path to clarity may be bumpy.”

    Some of the main moves in markets:

    Stocks

    • S&P 500 futures were little changed as of 11:35 a.m. Tokyo time
    • Japan’s Topix was little changed
    • Australia’s S&P/ASX 200 rose 0.4%
    • Hong Kong’s Hang Seng rose 0.8%
    • The Shanghai Composite fell 0.4%
    • Euro Stoxx 50 futures rose 0.2%

    Currencies

    • The Bloomberg Dollar Spot Index was little changed
    • The euro was little changed at $1.1674
    • The Japanese yen was little changed at 147.67 per dollar
    • The offshore yuan was little changed at 7.1719 per dollar

    Cryptocurrencies

    • Bitcoin fell 1.8% to $118,007.22
    • Ether fell 1.2% to $2,969.03

    Bonds

    • The yield on 10-year Treasuries was little changed at 4.44%
    • Japan’s 10-year yield advanced two basis points to 1.595%
    • Australia’s 10-year yield advanced two basis points to 4.39%

    Commodities

    • West Texas Intermediate crude fell 0.4% to $66.73 a barrel
    • Spot gold rose 0.2% to $3,349.13 an ounce

    This story was produced with the assistance of Bloomberg Automation.

    –With assistance from Abhishek Vishnoi and Winnie Hsu.

    ©2025 Bloomberg L.P.

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  • Adjunctive AI Provides Over 18 Percent Higher Lesion-Level Sensitivity on Prostate MRI

    Adjunctive AI Provides Over 18 Percent Higher Lesion-Level Sensitivity on Prostate MRI

    Adjunctive and stand-alone use of artificial intelligence (AI) both offered significantly enhanced lesion-level sensitivity for magnetic resonance imaging (MRI) detection of prostate cancer (PCa) in comparison to unassisted radiologist interpretation, according to a new study.

    For the multi-readers, multi-case (MRMC) study, recently published in Academic Radiology, the researchers assessed the use a deep learning model (uAI-prostateMR, United Imaging Intelligence) that was trained on 1,688 biparametric prostate MRI sequences. The cohort was comprised of 407 patients (mean age of 69.5) and 10 radiologists with an average three years of experience participated in the study.

    The study authors found that adjunctive AI provided an 85.5 percent lesion-level sensitivity for PCa in contrast to 67.3 percent for unassisted radiologist review.

    In a study that compared adjunctive AI, stand-alone AI and unassisted radiologist interpretation of biparametric prostate MRI scans for prostate cancer detection, researchers found that adjunctive and stand-alone AI both offered greater than 18 percent higher lesion-level sensitivity than radiologist interpretation.

    In addition to slightly higher specificity (79.5 percent vs. 75.9 percent), adjunctive AI provided a 10.8 percent higher area under the alternative free-response receiver operating characteristic curve (AFROC-AUC) in comparison to unassisted radiologist interpretation (86.9 percent vs. 76.1 percent).

    “The MRMC study provides robust evidence supporting the clinical utility of the AI system, enhancing its application for PCa detection and localization on biparametric prostate MRI,” wrote lead study author Zhaoyu Xing, M.D., who is affiliated with the Department of Urology at the Third Affiliated Hospital of Saachow University in Jiangsu, China, and colleagues.

    The researchers also noted that stand-alone use of AI led to an overall 88.4 percent lesion-level sensitivity, a 77.8 percent case specificity and an 83.1 percent AFROC-AUC.

    The greatest differences between deep learning model use and unassisted radiologist interpretation appeared to occur with the detection of small prostate cancer lesions. For PCa lesions < 1 cm in diameter, stand-alone AI offered an 82.6 percent lesion-level sensitivity, adjunctive AI had a 74.3 percent sensitivity and radiologists without the use of AI had a 38.3 percent sensitivity.

    Three Key Takeaways

    1. Adjunctive AI significantly boosts sensitivity. The addition of AI assistance to radiologist interpretation improved lesion-level sensitivity for prostate cancer (PCa) detection from 67.3 percent to 85.5 percent, with a modest gain in specificity and diagnostic accuracy (AFROC-AUC).
    2. AI outperforms radiologists in small lesions. Stand-alone AI achieved 82.6 percent sensitivity and adjunctive AI provided 74.3 percent sensitivity for detecting PCa lesions smaller than 1 cm in comparison to 38.3 percent sensitivity for unassisted radiologists, indicating this AI platform’s particular strength in detecting small lesions.
    3. Clinical utility supported despite study limitations. The study supports AI’s role in enhancing PCa detection and localization on biparametric prostate MRI, though findings are tempered by limitations like a controlled reading environment, limited MRI vendor diversity, and lack of clinical data access for readers.

    For PCa lesions > 3 cm, there was a 6.6 percent difference in lesion-level sensitivity between adjunctive AI (97 percent) and unassisted interpretation (90.4 percent), according to the researchers.

    “These results suggest that the AI system primarily enhanced the diagnosis and localization of smaller PCa lesions,” pointed out Xing and colleagues.

    (Editor’s note: For related content, see “Multinational Study Reaffirms Value of Adjunctive AI for Prostate MRI,” “Study: AI-Generated ADC Maps from MRI More than Double Specificity in Prostate Cancer Detection” and “Study: MRI-Based AI Enhances Detection of Seminal Vesicle Invasion in Prostate Cancer.”)

    In regard to study limitations, the authors acknowledged the use of a controlled online reading environment, a lack of access to clinical data for the reviewing radiologists, and that one MRI vendor was utilized for over 90 percent of the MRI exams.

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  • From residency to rocketship—how SmarterDx became a healthcare AI success story

    From residency to rocketship—how SmarterDx became a healthcare AI success story

    Clinicians are stepping into the entrepreneurial spotlight as AI transforms healthcare at breakneck speed—with rapid buy-in happening across the industry and providers leading the way, experimenting and implementing AI across multiple use cases. Consider SmarterDx: in just a few years, this healthcare AI rocketship has redefined how hospitals analyze patient records to unlock new revenue, elevate care quality, and streamline operations.

    “SmarterDx is an AI rocketship in healthcare.”

    The journey of Dr. Mike Gao (CEO) and Dr. Joshua Geleris (Chief Product and Data Science Officer), SmarterDx’s co-founders, was anything but straightforward. Rising from frontline medicine to industry leaders meant navigating clinical demands, pandemic turbulence, and the notoriously tough healthcare sales cycle. Their perseverance paid off, culminating in SmarterDx’s rapid ascent and recent acquisition by New Mountain Capital.

    Mike and Josh’s shared experience as practicing physicians exposed them to the systemic revenue leaks and documentation gaps plaguing hospitals. This clinical credibility empowered them to design AI that integrates seamlessly into hospital workflows—delivering value without disruption.

    We sat down with Mike and Josh to distill their hard-earned lessons for the next generation of healthcare AI founders. Their first piece of advice? “Don’t start a company during a global pandemic,” Josh quipped.

    As we looked back on Bessemer’s relationship with SmarterDx since our Series A investment, the founders unpacked how to navigate the eccentricities of healthcare, build enduring co-founder relationships, and master founder-led sales while scaling with discipline.

    The SmarterDx story is a blueprint for clinicians and technologists alike who are ready to build the future of healthcare—one patient record at a time.

    Takeaways on scaling a healthcare AI company from SmarterDX

    • Listening to customers drives product evolution
    • Maintaining patience and persistence is crucial with longer sales cycles
    • Founders need to lead the charge in early-stage sales
    • Talent is everything—focus on hiring quality

    Innovating in healthcare AI with clinical expertise and customer care

    Mike and Josh first crossed paths during their residency at NewYork-Presbyterian, quickly discovering a powerful combination: Mike’s healthcare systems acumen and customer empathy paired with Josh’s technical problem-solving and product vision as they frequently worked together on hospital digital transformation and artificial intelligence innovation efforts. Together, they forged a partnership grounded in mutual respect and a shared conviction that supercharging patient care is possible through smarter, more efficient hospital systems.

    At Bessemer, we saw the duo brought not only deep domain expertise and technical fluency to SmarterDx, but also a rare persistence and grit—traits we see in the very best founders and frontline clinicians. As Josh put it, “Mike has a talent for delivering a level of white glove service to customers I’ve never seen before. I’m still in awe of how he can instantly understand what they need and ensure we deliver on that promise.” Mike, in turn, admires Josh’s long-term product vision and technical depth: “Josh doesn’t just optimize for the short term—and he can architect an entire data pipeline for client onboarding, a level of engineering skill that’s incredibly rare among physicians.”

    Their experience offers a lesson for co-founders everywhere. Early on, Mike and Josh recognized the importance of owning distinct parts of the business. They naturally gravitated toward a division of labor: Mike as the external-facing “white glove” customer partner and sales lead, and Josh as the internal anchor for product, operations, and technical support. The key to their success has been complementary skills, deep mutual trust, and a willingness to stay hands-on across functions—setting the standards and ensuring quality as the company scaled at warp speed.

    SmarterDX’s response to COVID: Lessons in resilience for startups

    In their industry, every startup faces long sales cycles, fragmented buyers, and deceptively narrow markets—but a global pandemic forced Mike and Josh to rethink momentum from the ground up.

    “In the early days, we saw immediate traction—two out of our first three hospitals wanted to move forward,” Mike recalled. “Then COVID hit, and a Chief Medical Officer told us, ‘I have to deal with this coronavirus. Can I get back to you in a couple weeks?’ That hospital became a customer three years later—a stark reminder of how much this industry is at the mercy of macro events and just how drawn-out sales cycles can be.”

    Of course, a few weeks became months with COVID, and so did the potential customer conversations. Even after the initial crisis, hospitals remained unstable and hesitant to engage with new vendors, leaving Mike and Josh in a year-and-a-half holding pattern. They returned to serve as hospitalists, waiting patiently until the market was ready to re-engage.

    This experience highlights a core founder principle: master the rhythm of when to push, when to pause, and the patience required to build trust in healthcare. Customer relationships were the engine of innovation—nuanced feedback from early partners drove product pivots and go-to-market refinement. Their adaptability, relentless customer focus, and knowing how to weather slow periods and seize momentum when it returns set SmarterDx apart and fueled their breakout growth.

    Founder-led sales for early-stage success

    Winning in healthcare starts with founders driving early sales to uncover real product-market fit. SmarterDx’s team discovered that selling directly to customers revealed what resonated—and what didn’t.

    “Early on, we pitched a concurrent CDI solution, but customer feedback pushed us to pivot to post-discharge analysis, focusing only on net-new findings,” shared Mike on developing their SmarterPrebill™ solution. “We learned that offering too many options confused buyers; simplifying our pitch to a single, clear value proposition was the breakthrough.”

    But the real test? When you can run a clear-cut, 20-minute call that consistently lands—only then is your sales message ready to scale beyond the founders.

    As Josh put it, “In healthcare, you only get a handful of shots with potential customers, and each conversation yields just a sliver of feedback—maybe one or two questions. But those questions are gold. Mike excelled at obsessively analyzing every customer query, connecting insights across months, and refining both pitch and product. If we’d just kept selling what we thought was best, we’d have missed our breakthrough. By triangulating these subtle signals, we discovered the core product and go-to-market engine that fueled our growth.”

    Three rules for founder-led sales:

    • Treat every customer conversation as a learning opportunity.
    • Obsessively analyze every question or objection to refine your pitch and product.
    • Don’t scale sales until you have a repeatable, teachable motion that lands.

    What the SmarterDx founders wish they knew at the early stage

    As our conversation wrapped up, Josh shared a moment of vulnerability:

    “On a podcast, I was listening to Jensen Huang from NVIDIA, and when asked what kind of company he’d start today, he said, ‘I wouldn’t do it. It’s too hard.’ I nearly cried walking my dog—it resonated so deeply. Building a company is one of the hardest things you’ll ever do. My advice: be prepared, go all in, and know it’s not for the faint of heart.”

    From their trials, Mike and Josh distilled these essential lessons for early-stage founders:

    1. Listening to customers drives product evolution: Actively listen to your customers and use their feedback to refine your product and value proposition, especially during longer sales cycles.
    2. Maintaining patience and persistence is crucial with longer sales cycles: Recognize the inflection point. In healthcare, product-market fit is often hindered by long sales cycles. But when growth accelerates, founders must adapt quickly or risk being outpaced by demand. Hypergrowth—like scaling 600% a year—means even rapid hiring can’t keep up.
    3. Founders need to lead the charge in early-stage sales: Before product-market fit, stay scrappy, do everything yourself, and iterate fast. Once you hit product-market fit, shift gears—resource aggressively to capture the market. Don’t underinvest when the signal is clear.
    4. Talent is everything—focus on hiring quality: Maintain a relentless focus on hiring quality, even when you’re understaffed. The long-term payoff of a high-talent bar far outweighs the temptation to hire quickly just to fill seats.

    SmarterDx’s journey from early stage to acquisition is a case study in the power of “compounding learning”—years of domain immersion and customer discovery create an unshakeable foundation for scale. Mike and Josh’s unwavering focus on solving real problems, listening to customers, and executing with discipline turned SmarterDx into one of healthcare AI’s standout successes. We’re so grateful to them both for letting Bessemer be part of their exceptional journey.

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