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  • ‘Interstellar visitor’ 3I/ATLAS could be the oldest comet ever seen — and could grow a spectacular tail later this year

    ‘Interstellar visitor’ 3I/ATLAS could be the oldest comet ever seen — and could grow a spectacular tail later this year

    The mysterious “interstellar visitor” that was recently spotted whizzing through the solar system may be around 3 billion years older than our cosmic neighborhood, a new study suggests. If confirmed, the alien interloper would be the oldest comet ever seen from Earth. And, if it’s made of what researchers think it is, it may also grow a spectacularly long tail in the coming months.

    3I/ATLAS is an interstellar comet, potentially up to 15 miles (24 kilometers) across, that is currently shooting toward the sun at more than 130,000 mph (210,000 km/h). Once it passes its closest point to our home star, or perihelion, in late October, the extrasolar entity will begin its long journey back out of the solar system, before eventually leaving us behind forever.

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  • Nominees, times, and how to watch the Excellence in Sports Performance Yearly awards ceremony live

    Nominees, times, and how to watch the Excellence in Sports Performance Yearly awards ceremony live

    The stars of Paris 2024 and the global sporting world are set for a big night on Wednesday (16 July) as the 2025 ESPY (Excellence in Sports Performance Yearly) awards honour the best and brightest in the US and beyond.

    The ceremony, which will be hosted by comedian Shane Gillis and held in Los Angeles’ Dolby Theatre, has a star-studded roster of Olympic champion nominees from Team USA, including gymnasts Simone Biles and Suni Lee, track athletics stars Sydney McLaughlin-Levrone and Gabby Thomas, basketball legend Stephen Curry, and footballer Trinity Rodman.

    Several awards include nominees from outside the US for their impact on the world of sport, both in North America and around the globe, including Japan’s baseball sensation Shohei Ohtani, Irish golf star Rory McIlroy, and Spanish tennis phenomenon Carlos Alcaraz.

    In addition, rapper Busta Rhymes, hip-hop duo Clipse, and rapper and singer Tobe Nwigwe are scheduled to perform at the event.

    Read on for the full list of nominees and how to watch live.

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  • Stunning Images and Asteroids Aplenty

    Stunning Images and Asteroids Aplenty

    The NSF-DOE Rubin Observatory has officially begun its journey to map the universe, and it started with a remarkable feat: capturing over 4,000 asteroids, including 2,100 brand new discoveries, in just ten hours of test imaging. One of the leaders in this groundbreaking effort is Dr. Beth Willman, CEO of the LSST Discovery Alliance, who joined SETI Institute communications specialist Beth Johnson on a special SETI Live to discuss the observatory’s first light, the astonishing data pipeline behind it, and the future of public engagement with Rubin’s unprecedented volume of data.

    The Rubin Observatory, located in Chile and supported by the National Science Foundation and the Department of Energy, is designed to survey the entire southern sky every three nights for ten years, capturing over 20 billion galaxies and trillions of cosmic objects along the way. This massive initiative marks a shift not only in how we observe the cosmos but also in how researchers and the public can participate in discovery.

    The Technology Behind the Rubin Observatory

    Rubin’s performance during the initial engineering observations exceeded expectations. At the core of the system is the Simonyi Survey Telescope, a rapid-slewing structure paired with a 3.2-gigapixel camera — currently the largest ever built for astronomy. These components work in tandem with an advanced data management system that handles real-time analysis of astronomical images as they’re captured.

    Dr. Willman explained how images are read from the camera’s 3.2 billion pixels in just two seconds. From there, the data travels down the Cerro Pachón mountain, through South America, and around the world to international data centers, including SLAC in California. Within minutes, potential asteroid detections are processed and reported to the IAU’s Minor Planet Center.

    What makes this system exceptional is not just its speed but its scale. “You’re getting a new image every 40 seconds, every night, for ten years,” Dr. Willman noted. “It’s a huge volume of data, and it has only just begun.”

    Cosmic Treasures in a Ten-Hour Test

    Among the highlights of the first look were images of the Trifid and Lagoon Nebulae. Another highlight was a stitched mosaic image, created from over 1,100 exposures, covering 15 square degrees of the sky near the Virgo Cluster. It revealed a breathtaking “cosmic treasure chest” of stars, galaxies, and moving objects. The observatory’s sensitivity even allowed the team to detect 2,100 previously unknown asteroids, demonstrating Rubin’s potential to significantly enhance planetary defense.

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  • Spacecraft can navigate using light from just two stars – Physics World

    Spacecraft can navigate using light from just two stars – Physics World

    Exit strategy Artist’s impression of New Horizons as it flew past Pluto in 2015. (Courtesy: Johns Hopkins University Applied Physics Laboratory/Southwest Research Institute)

    NASA’s New Horizons spacecraft has been used to demonstrate simple interstellar navigation by measuring the parallax of just two stars. An international team was able to determine the location and heading of the spacecraft using observations made from space and the Earth.

    Developed by an international team of researchers, the technique could one day be used by other spacecraft exploring the outermost regions of the solar system or even provide navigation for the first truly interstellar missions.

    New Horizons visited the Pluto system in 2015 and has now passed through the Kuiper Belt in the outermost solar system.

    Now, NOIRLab‘s Tod Lauer and colleagues have created a navigation technique for the spacecraft by choosing two of the nearest stars for parallax measurements. These are Proxima Centauri, which is just 4.2 light–years away, and Wolf 359 at 7.9 light–years. On 23 April 2020, New Horizons imaged star-fields containing the two stars, while on Earth astronomers did the same.

    At that time, New Horizons was 47.1 AU (seven billion kilometres) from Earth, as measured by NASA’s Deep Space Network. The intention was to replicate that distance determination using parallax.

    Difficult measurement

    The 47.1 AU separation between Earth and New Horizons meant that each vantage point observed Proxima and Wolf 359 in a slightly different position relative to the background stars. This displacement is the parallax angle, which the observations showed to be 32.4 arcseconds for Proxima and 15.7 arcseconds for Wolf 359 at the time of measurement.

    By applying simple trigonometry using the parallax angle and the known distance to the stars, it should be relatively straightforward to triangulate New Horizons’ position. In practice, however, the team struggled to make it work. It was the height of the COVID-19 pandemic, and finding observatories that were still open and could perform the observations on the required night was not easy.

    Edward Gomez, of the UK’s Cardiff University and the international Las Cumbres Observatory, recalls the efforts made to get the observations. “Tod Lauer contacted me saying that these two observations were going to be made, and was there any possibility that I could take them with the Las Cumbres telescope network?” he tells Physics World.

    In the end, Gomez was able to image Proxima with Las Cumbres’ telescope at Siding Spring in Australia. Meanwhile, Wolf 359 was observed by the University of Louisville’s Manner Telescope at Mount Lemmon Observatory in Arizona. At the same time, New Horizons’ Long Range Reconnaissance Imager (LORRI) took pictures of both stars, and all three observations were analysed using a 3D model of the stellar neighbourhood based on data from the European Space Agency’s star-measuring Gaia mission.

    The project was more a proof-of-concept than an accurate determination of New Horizons’ position and heading, with the team describing the measurements as “educational”.

    “The reason why we call it an educational measurement is because we don’t have a high degree of, first, precision, and secondly, reproducibility, because we’ve got a small number of measurements, and they weren’t amazingly precise,” says Gomez. “But they still demonstrate the parallax effect really nicely.”

    New Horizons position was calculated to within 0.27 AU, which is not especially useful for navigating towards a trans-Neptunian object. The measurements were also able to ascertain New Horizon’s heading to an accuracy of 0.4°, relative to the precise value derived from Deep Space Network signals.

    Just two stars

    But the fact that only two stars were needed is significant, explains Gomez. “The good thing about this method is just having two close stars as our reference stars. The handed-down wisdom normally is that you need loads and loads [of stars], but actually you just need two and that’s enough to triangulate your position.”

    There are more accurate ways to navigate, such as pulsar measurements, but these require more complex and larger instrumentation on a spacecraft – not just an optical telescope and a camera. While pulsar navigation has been demonstrated on the International Space Station in low-Earth orbit, this is the first time that any method of interstellar navigation has been demonstrated for a much more distant spacecraft.

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    The New Horizons probe

    New Horizons probe may have observed light from decaying dark matter

    Today, more than five years after the parallax observations, New Horizons is still speeding out of the solar system. It has cleared the Kuiper Belt and today is 61 AU from Earth.

    When asked if the parallax measurements will be made again under better circumstances Gomez replied. “I hope so. Now that we’ve written a paper in The Astronomical Journal that’s getting some interest, hopefully we can reproduce it, but nothing has been planned so far.”

    In a way, the parallax measurements have brought Gomez full-circle. “When I was doing [high school] mathematics more years ago than I care to remember, I was a massive Star Trek fan and I did a three-dimensional interstellar navigation system as my mathematics project!”

    Now here he is, as part of a team using the stars to guide our own would-be interstellar emissary.

     

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  • OpenEvidence, the Fastest-Growing Application for Physicians in History, Announces $210 Million Round at $3.5 Billion Valuation

    OpenEvidence, the Fastest-Growing Application for Physicians in History, Announces $210 Million Round at $3.5 Billion Valuation

    OpenEvidence also announces the wide release of OpenEvidence DeepConsult™—the first AI agent purpose-built for physicians

    CAMBRIDGE, Mass., July 15, 2025 /PRNewswire/ — OpenEvidence, the most widely used medical search and AI application among verified U.S. clinicians, today announced a $210 million Series B round at a $3.5 Billion valuation. Google Ventures and Kleiner Perkins co-led the Series B round. Sequoia Capital, which led OpenEvidence’s Series A round earlier in 2025, followed on in this round. The round also included investments from Coatue, Conviction, and Thrive. OpenEvidence has raised more than $300 million since its founding.

    OpenEvidence helps clinicians make high-stakes clinical decisions at the point of care. 
    OpenEvidence is redefining evidence-based medicine in real-time and transforming how frontline healthcare providers access, evaluate, and apply the world’s medical knowledge. OpenEvidence is actively used across more than 10,000 hospitals and medical centers nationwide and by more than 40% of physicians in the United States who log in daily to make high-stakes clinical decisions at the point of care. OpenEvidence continues to grow by over 65,000 new verified U.S. clinician registrations each month. In July of 2024, OpenEvidence supported approximately 358,000 logged-in, verified U.S. physician consultations in one month. One year later, OpenEvidence now handles that many each workday—and supports over 8,500,000 clinical consultations by logged-in, verified U.S. physicians per month—a 2,000%+ year-over-year growth rate. More than 100 million Americans this year will be treated by a doctor who used OpenEvidence.

    Clinicians are overwhelmed by information overload, with the volume of medical research published annually doubling every five years. Traditional medical evidence databases are slow, fragmented across multiple platforms, and require extensive manual searching that pulls physicians away from patient care. Through an array of strategic content partnerships (including the American Medical Association, The New England Journal of Medicine, The Journal of the American Medical Association, and all eleven JAMA specialty journals—such as JAMA Oncology and JAMA Neurology) OpenEvidence gives clinicians the power to search once, skip the scavenger hunt, and surface the science in seconds. Clinicians using OpenEvidence (which is HIPAA compliant) can input clinical questions or patient case details and receive point-of-care answers grounded in the latest research, complete with references and even follow-up suggestions. OpenEvidence rapidly surfaces relevant medical knowledge, synthesizes medical research, and gives clinicians the power to make faster, more evidence-based decisions—accelerating both medical literature review and clinical decision support. By reducing the lag between new evidence and bedside application, OpenEvidence enables improved patient outcomes.

    “At a time when U.S. healthcare faces the dual challenges of clinician burnout and a projected physician shortfall of nearly 100,000 by 2030, the question of AI’s role in bridging the gap is paramount,” says Daniel Nadler, founder of OpenEvidence. “When physicians’ lives are hard, patients’ lives are harder. OpenEvidence’s commitment to building an AI copilot for clinicians is rooted in the belief that AI will be a force for good in the world, ultimately benefiting both healthcare professionals and the patients they serve. Physicians are superheroes, and OpenEvidence is giving these superheroes new superpowers.”

    Daniel Nadler is a magnet for talent, attracting top AI researchers and a world-class medical advisory board,” said Sangeen Zeb, General Partner at Google Ventures. “As a firm with a life sciences team largely composed of physicians and scientists, we deeply understand the challenges clinicians face with traditional tools. Physicians are drowning in information but starving for timely insights. OpenEvidence changes that equation, bringing clinicians into the modern era. As early investors in Daniel’s first company, Kensho, GV has been privileged to know him for over a decade. He is a once-in-a-generation founder building one of the fastest-growing technology applications ever seen.”

    Legendary investor and Kleiner Perkins Chairman John Doerr—who co-led Google’s original Series A and has served on its board since 1999—said, “It’s hard to imagine a better use for AI than OpenEvidence. Daniel Nadler and his world-class team are building what I believe will become an AI-era treasure, a life-saving resource for doctors, patients, and their families. I can’t imagine the future without it.”

    “It’s exceptionally rare to see a product reach this level of adoption—let alone among physicians, who are notoriously hard to win over and exacting in what they trust—and the fact that 40% of all physicians in the United States log in daily to OpenEvidence’s software is a staggering signal of both trust and utility,” said Mamoon Hamid, Managing Partner at Kleiner Perkins. “OpenEvidence is not just building a company, they’re setting a new global standard for how evidence-based medical decisions are made. We’re proud to support a mission with this kind of generational ambition.”

    OpenEvidence has announced key strategic content partnerships with the American Medical Association (JAMA) and The New England Journal of Medicine so that full-text content and multimedia from the global gold standards of medical knowledge are used to inform answers in OpenEvidence—giving physicians, medical researchers, and healthcare professionals faster access to clinically relevant evidence to improve patient outcomes and save lives.

    Robert M. Wachter, MD, Chair of the Department of Medicine at UCSF and author of the upcoming book, A Giant Leap: How AI is Transforming Healthcare and What That Means for Our Future, said, “Thus far, the digital transformation of healthcare has mostly fallen short in its efforts to deliver trusted, evidence-based clinical decision support to clinicians when they need it most. The partnership between the American Medical Association, a cornerstone of medical research and analysis for more than a century, and OpenEvidence, my preferred platform for AI-powered clinical insights, represents a significant step toward fulfilling that promise. I’m confident that both clinicians and patients will benefit.”

    OpenEvidence, founded by Harvard– and MIT-trained PhDs, also today announced the wide release of OpenEvidence DeepConsult™, the first AI agent purpose-built for physicians. DeepConsult empowers every physician with a personal, private team of PhD-level, medically-specialized AI agents built by OpenEvidence—capable of conducting advanced medical research while the physician steps away, whether to see the next patient, take a lunch break, or get some rest. OpenEvidence DeepConsult agents use advanced reasoning models to autonomously analyze and cross-reference hundreds of peer-reviewed medical studies in parallel—surfacing not just direct answers, but novel, cross-cutting connections across the literature that might otherwise go unnoticed. The result is an evidence-based synthesis: An integrative, interdisciplinary understanding distilled from hundreds of peer-reviewed medical studies—what would otherwise take a human researcher months of painstaking effort to produce for a single clinical topic.

    While OpenEvidence’s core search product is designed for speed—returning precise, evidence-based answers in the 5–10 seconds physicians often have between patients—DeepConsult addresses a different kind of clinical use case: when physicians have more time to ramp up on a new body of knowledge. A physician can pose a complex question before heading to lunch—and return to a comprehensive PhD-level research report in their inbox by the time they get back. This marks a new era of medical productivity: tireless, agentic assistants—PhD-level research intelligence, never tired, never off-duty—reasoning at unprecedented scale, uncovering insights, unlocking new knowledge, and reshaping the future of care.

    Each DeepConsult run requires over 100 times the compute and cost of a standard OpenEvidence search. Some leading foundation model companies have publicly speculated about charging tens of thousands of dollars per month for their envisioned PhD‑level agents that are still under development. Yet as part of its mission to support physicians at the point of care, OpenEvidence is offering DeepConsult entirely free to all verified U.S. clinicians—regardless of their institution or workplace.

    OpenEvidence will use the funding to expand strategic content partnerships that enhance its library of advanced medical knowledge. OpenEvidence was founded by serial entrepreneur Daniel Nadler, founder of Kensho. Kensho became the most valuable artificial intelligence company of the 2010s when S&P Global acquired it for $700 million in 2018. Google Ventures was the first major investor in Kensho, funding the company while Daniel Nadler was completing his PhD at Harvard University. In 2025, OpenEvidence founder Daniel Nadler was named to the TIME100 Health list of the 100 Most Influential People in global health.

    About OpenEvidence

    OpenEvidence is the fastest-growing clinical decision support platform in the United States, and the most widely used medical search engine among U.S. clinicians. Trusted by hundreds of thousands of verified physicians, nurses, and other healthcare professionals, OpenEvidence is actively used across more than 10,000 hospitals and medical centers nationwide and by over 40% of physicians in the United States who log in daily to make high-stakes clinical decisions at the point of care.

    OpenEvidence continues to grow by over 65,000 new verified U.S. clinician registrations each month. Aside from Google itself, there has never been a piece of technology adopted by clinicians as quickly as OpenEvidence. OpenEvidence is transforming how frontline healthcare providers access, evaluate, and apply the world’s medical knowledge. More than 100 million Americans this year will be treated by a doctor who used OpenEvidence.

    OpenEvidence was founded by Daniel Nadler and Zachary Ziegler. Founded with the mission to organize and expand global medical knowledge, OpenEvidence is redefining evidence-based medicine in real-time. In recognition of this impact, in 2025, OpenEvidence founder Daniel Nadler, PhD, was named to the TIME100 Health list of the 100 Most Influential People in global health.

    SOURCE OpenEvidence

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  • Skull and Bones’ New Season, Oaths of War, Makes Big Waves

    Skull and Bones’ New Season, Oaths of War, Makes Big Waves

    Skull and Bones Year 2 Season 2, Oaths of War, is here, and it’s bringing big changes to the Indian Ocean. From a new large ship to an explosive faction war to new Megafort raids, let’s dive into everything the latest season has to offer:

    You’ve been asking for it, and now it’s here: a large ship has been introduced to Skull and Bones, armed with devastating broadside capabilities, dual auxiliary slots, and fleet-augmenting benefits. The Frigate is a tank class ship that radiates a fortifying aura to protect its allies. Its perk is Grit, which stacks when taking damage, with a maximum of 10 stacks. Each stack of Grit lasts 15 seconds and increases Armor by 40. When stacks of Grit are active, you’ll take 10% additional damage while every extra-small, small, and medium ship within 200 meters will take 10% reduced damage – until you reach a full 10 stack, when allied ships will take 20% reduced damage instead. The Frigate’s Upgrade Perk, Payback, enables the ship to stack Grit when dealing damage. The blueprint for the Frigate can be acquired in the Smuggler Pass.

    A new ship also means a new weapon. The Demolition Mortar is designed to take out Forts and other structures on land. When used against those buildings, damage is increased 300%, and it automatically deals 30% explosive damage within a 30 meter blast radius. It can be acquired with seasonal currency from the Black Market, or through the DMC Faction Reputation Shop.

    Faction War is coming in the mid-season update, when tensions between the Compagnie Royale and the Dutch Merchant Company have exploded, and it’s time for you to pick a side. The season will feature different battle phases, during which you’ll fight rival factions for Contested Zones, where you’ll collect War Assets for your own team. Then, during Invasion Events, you can choose to defend your War Assets or attack enemies to steal theirs. Securing Contested Zones and winning Invasion Events will net you war rewards, and you’ll be able to purchase unique faction equipment, like the Demolition Mortar, powerful epic-level furniture variants, and more from the Pirate Broker at the Faction Reputation Shop.   

    At the end of each battle phase, you’ll have the option to stay loyal or betray your chosen side. The choices players make will have a direct impact on Skull and Bones in Season 3, where the winning faction will be reflected in the narrative.

    Team up with allies to take on Megaforts in a new kind of raid. The new Megafort attack experience will feature multiple battle phases, as the towers awaken after you defeat a mini-boss, escalating pressure as the Megafort launches special attacks and a fleet to defend itself. You and your allies will need to strategically coordinate in order to withstand the barrage and take home the rewards. Successfully taking out a Megafort will net you valuable Ascension materials.

    Skull and Bones’ new season will also feature limited-time events such as Darktide Lullaby and Moonshine Larceny, ship campaigns for pirate legends, and a new Smuggler Pass full of valuable rewards and special cosmetic items.

    If you haven’t had a chance to dive into the action on the Indian Ocean yet, Skull and Bones is hosting a Free Weekend from July 17-21 on PlayStation, Xbox, and PC via Ubisoft Connect. If you buy the game, which is on sale for up to 80% off until July 24 as part of the Ubisoft Store’s Summer Sale, all your progress will carry over. Skull and Bones is available now for PS5, Xbox Series X|S, Amazon Luna, and PC via Ubisoft Connect, Steam, and the Epic Games Store, as well as with a Ubisoft+ Premium subscription.

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  • IND vs ENG Test: Where did India lose the Lord’s Test? Ex-India captain opines | Cricket News

    IND vs ENG Test: Where did India lose the Lord’s Test? Ex-India captain opines | Cricket News

    London: India’s Mohammed Siraj plays a shot during the fifth day of the third test cricket match between India and England, at the Lord’s Cricket Ground, in London. (PTI Photo/R Senthilkumar) (PTI07_14_2025_000529B)

    Ajinkya Rahane has pointed out various reasons why India lost the Lord’s Test match against England in the ongoing five-match Test series.Rahane said Pant’s run-out in the first innings and then Karun Nair’s brain fade in the second cost India dearly.“I thought Ben Stokes attacking the ball, one-handed pick-up and throwing towards the non-striker was amazing. It’s very easy for the fielder to get relaxed,” Rahane said on his YouTube channel.“When you see only two or three balls left before lunch, you can easily get relaxed. But his attitude towards the ball, his intensity, and getting that run-out — that’s where I felt England came into the game.”

    Rishabh Pant is India’s TRUMP CARD in tense chase vs England at Lord’s

    However, Rahane felt India were cruising in the second innings despite losing Jaiswal’s wicket early while chasing 193.“At that point in time, India were cruising — 40-odd for one. But that LBW of Karun Nair, that changed the game for India and England.“I thought England came back into the game really well. And after that, they started bowling well. Their intensity on the field, their fielders, the character they showed — it was amazing.“That’s what you want to see in Test cricket — all 11 fielders coming together and looking to win the Test match. It was so good to see their attitude and character on the field.“Even though India fought back really well, again, credit goes to the England team — the way they came back into the game and won the Test match,” he said.

    Lord’s museum tour: Cricket’s greatest artifacts and the stories behind them

    Talking about where India lost the Test match, the 37-year-old said: “As I said earlier, it was India’s Test match to win.“When KL and Rishabh were batting in the first innings, I thought their partnership was amazing. They batted beautifully. But India was 75–100 runs short.“We all know that Day 4 and 5 get slightly difficult to bat on. It’s not easy to score runs. Yes, England bowled really well.“But I felt India missed an opportunity to get that big score on the board in the first innings. And also, I feel going forward, India should look to add one extra bowler — because you’re going to win a Test match or a Test series by getting 20 wickets.”


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  • Transcriptomics Reveal Core ACD Immune Pathways

    Transcriptomics Reveal Core ACD Immune Pathways

    While patch testing remains the cornerstone of diagnosis for allergic contact dermatitis (ACD), the immunologic events driving elicitation—the phase responsible for symptom onset—are incompletely understood.1 A recent study by Pesqué et al published in Allergy, provides new clinical and molecular insights into this process by conducting a comprehensive transcriptomic analysis of strong and extreme patch test reactions in non-atopic individuals.2

    Methods and Materials

    The study examined 40 severe (2+ or 3+) patch test reactions to 4 chemically distinct allergens: nickel, 2-hydroxyethylmethacrylate (2-HEMA), methylisothiazolinone (MIT), and formaldehyde. Only non-atopic individuals, verified through stringent diagnostic criteria and dermatological assessments, were included to minimize confounding from comorbid atopic dermatitis, which is known to alter ACD immune profiles. Nineteen petrolatum-exposed controls were also analyzed.

    RNA sequencing of 3 mm punch biopsies collected 96 hours post-patch test revealed a robust set of differentially expressed genes (DEGs), with over 800 genes commonly upregulated across all allergens compared to controls. Key shared pathways were dominated by both innate and adaptive immune responses. Top DEGs included chemokines (e.g., CXCL10, CCL17), cytokine regulators (e.g., IL13, IL23A), and markers of dendritic cell activation and T-cell signaling.

    Results

    Although a strong common “ACD transcriptomic signature” was identified, researchers stated notable allergen-specific molecular patterns also emerged. Nickel and 2-HEMA reactions in particular exhibited distinct sets of DEGs. Nickel-specific genes were associated with cell cycle and innate immune responses—some overlapping with previously described irritant contact dermatitis pathways—raising the possibility of a dual inflammatory-irritant profile. In contrast, 2-HEMA uniquely activated B-cell receptor and antigen processing pathways, alongside markers of type 2 (e.g., CCL11) and type 1 (e.g., IL18R1) immunity.

    Researchers noted allergens uniformly elicited mixed T-helper cell responses. Type 1/Th1 pathways were dominant, researchers noted, with strong IFN-γ–related signatures. Type 3/Th17 responses also featured prominently, reinforcing recent findings of their role in ACD pathology. Type 2/Th2 signals were present but less prominent. These findings contrast with previous research that suggested greater Th2 involvement, particularly in atopic individuals or fragrance allergens, highlighting the impact of comorbidities and allergen type.

    Interestingly, partially shared DEGs between allergen pairs further delineated subgroup-specific immunologic features, such as IL6R and LOXL3 in 2-HEMA and MIT combinations, and Th2-biased markers in certain mixtures. Researchers said these partially shared genes contribute to the complexity of immune polarization in ACD.

    Downregulated genes across all allergens were primarily associated with epidermal structural components (e.g., FLG2, LORICRIN), indicating impaired skin barrier homeostasis during elicitation. This aligns with the visible spongiotic features noted histologically in all reactions and supports the hypothesis that inflammation-driven barrier dysfunction is intrinsic to ACD pathogenesis.

    Conclusion

    The study is notable for its rigorous exclusion of atopic dermatitis and its focus on strong-to-extreme ACD reactions, which may explain the amplified core inflammatory transcriptomic profile observed. However, limitations include the small cohort size, and the restricted number of allergens studied. Additional research across broader patient populations and allergen classes is needed to validate these findings and explore clinical implications, particularly for biomarker development or therapeutic modulation.

    This research highlights a dual pattern of shared and allergen-specific immune responses in ACD elicitation, dominated by type 1 and type 3 immunity in non-atopic individuals. Researchers behind the study hope these insights advance understanding of ACD pathophysiology and provide a foundation for more precise diagnostic and therapeutic strategies.

    References

    1. Dhingra N, Shemer A, Correa da Rosa J, et al. Molecular profiling of contact dermatitis skin identifies allergen-dependent differences in immune response. J Allergy Clin Immunol. 2014;134(2):362-372. doi:10.1016/j.jaci.2014.03.009
    2. Pesqué D, Andrades E, Berenguer-Molins P, et al. Transcriptomic analysis of allergic patch test reactions in non-atopic patients: A comparative study across multiple allergens. Allergy. Published online July 9, 2025. doi:10.1111/all.16642

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  • Trump administration has begun search for next Fed Chair – Financial Times

    Trump administration has begun search for next Fed Chair – Financial Times

    1. Trump administration has begun search for next Fed Chair  Financial Times
    2. Bessent Suggests Powell Should Leave Fed Board in May  Bloomberg
    3. Bessent Steps Up Criticism of Fed as Auditions for Chair Intensify  The New York Times
    4. Trump economic adviser Kevin Hassett is rising in race for next Fed chief  The Washington Post
    5. US Treasury Secretary Bessent says ‘formal process’ for Powell successor has started, Bloomberg News reports  Reuters

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