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  • Xbox Graphics department ad uses embarrassing AI-generated image

    Xbox Graphics department ad uses embarrassing AI-generated image

    Windows and Xbox publisher Microsoft has significantly ramped up its focus on and use of artificial intelligence (AI) this year, with the firm pushing strongly for the internal use of Copilot in its workflows and prioritizing employees that represent “critical AI talent” — even as tensions between it and partner OpenAI have reportedly risen over time.

    It’s not a surprise, then, to see an AI-generated image get used for one of the company’s hiring advertisements. What is surprising, though, is how shockingly and embarrassingly dumb it is.

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  • Mars was Warm and Wet 3.7 Billion Years Ago, New Study Suggests

    Mars was Warm and Wet 3.7 Billion Years Ago, New Study Suggests

    Planetary scientists have discovered more than 15,000 km of ancient riverbeds in Noachis Terra, a region in Mars’ southern highlands. This discovery suggests that Mars may once have been much wetter than previously thought.

    This HiRISE image shows a flat top, heavily eroded fluvial sinuous ridge on Mars; sand dunes can be seen migrating over the top of the fluvial sinuous ridge. Image credit: NASA / JPL / University of Arizona.

    The nature of the Martian climate during the Noachian-Hesperian transition, a period of geologic and climatic changes around 3.7 billion years ago, and how surface features such as valley networks and lakes associated with liquid water formed, is debated.

    There are two theories: the first is that warm and wet conditions persisted on early Mars long enough that liquid water was stable on the surface for extended periods; the second is that Mars was generally cold and dry, and that geological features indicative of flowing water were formed only very sporadically by meltwater from ice sheets during short climate excursions.

    Noachis Terra is a region where ‘warm, wet’ climate models predict high rates of precipitation.

    In new research, Open University Ph.D. student Adam Losekoot and his colleagues looked at fluvial sinuous ridges, also known as inverted channels, across this region.

    “These are believed to have formed when sediment deposited by rivers hardened and was later exposed as the surrounding material eroded,” the authors said.

    “Similar ridges have been found across a range of terrains on Mars.”

    “Their presence suggests that flowing water was once widespread in this region, with precipitation being the most likely source of this water.”

    They found fluvial sinuous ridges to be common across Noachis Terra, with a cumulative length of more than 15,000 km.

    These are often isolated segments, but some systems are hundreds of km in length.

    “Studying Mars, particularly an underexplored region like Noachis Terra, is really exciting because it’s an environment which has been largely unchanged for billions of years,” Losekoot said.

    “It’s a time capsule that records fundamental geological processes in a way that just isn’t possible here on Earth.”

    For the study, the researchers used data from three orbital instruments: the Context Camera (CTX), the Mars Orbiter Laser Altimeter (MOLA) and the High Resolution Imaging Science Experiment (HiRISE).

    These datasets allowed them to map the locations, lengths and morphologies of ridge systems across a wide area.

    “Our work is a new piece of evidence that suggests that Mars was once a much more complex and active planet than it is now, which is such an exciting thing to be involved in,” Losekoot said.

    “The fact that the ridges form extensive interconnected systems suggests that the watery conditions must have been relatively long-lived, meaning Noachis Terra experienced warm and wet conditions for a geologically relevant period.”

    “These findings challenge existing theories that Mars was generally cold and dry, with a few valleys formed by ice-sheet meltwater in sporadic, short periods of warming.”

    The scientists presented their results on July 10 at the Royal Astronomical Society’s National Astronomy Meeting 2025 in Durham, the United Kingdom.

    _____

    Adam Losekoot et al. The Fluvial History of Noachis Terra, Mars. NAM 2025

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  • A Lunar Base Could Start with a Dome over a Crater Made of Regolith

    A Lunar Base Could Start with a Dome over a Crater Made of Regolith

    When the first astronauts walked on the Moon as part of the Apollo Program, the concept of lunar habitats ceased being the stuff of science fiction and became a matter of scientific study. With several space agencies planning on sending crewed missions to the Moon in the coming decade, these plans have become the subject of scientific interest again. Structures that will enable a “sustained program of lunar science and development” is the long-term aim of NASA’s Artemis Program. China and the ESA have similar plans with the International Lunar Research Station (ILRS) and the Moon Village.

    To limit the amount of materials that need to be launched for the Moon and reduce reliance on Earth, these plans will incorporate local resources for building materials and resources – in-situ resource utilization (ISRU). In a recent study, researchers from Poland and the UK proposed a developmental pathway for a lunar habitat that begins with a dome built using a regolith-based geopolymer. This dome would enclose a 17-meter (~56 ft) diameter crater in the Mare Tranquillitatis region that would house all the necessary buildings for a lunar base.

    The research was led by Magdalena Mrozek, a Research Assistant with the Faculty of Civil Engineering at the Silesian University of Technology in Gliwice, Poland. She was joined by Dawid Mrozek and Mateusz Smolana, also researchers from the Silesian University of Technology, and Lorna Anguilano, a Senior Research Fellow with the Brunel University London, and the Assistant Director of the Wolfson Centre for Sustainable materials development and Processing. The paper that describes their findings recently appeared in Scientific Reports.

    Apollo-12 astronaut Alan L. Bean operating on the lunar lander. Credit: NASA

    The concept outlined in their paper represents a simplified concept for a lunar base that would leverage ISRU and the production of geopolymers on-site. The site location also offers several advantages, not the least of which is protection from meteoroid impacts and the ejecta these produce. They also selected a mare region, which are lower in elevation than highland terrains and have a higher crater density. In addition, the Mare Tranquillitatis region near the Apollo 11 landing site (0.67 North by 23.47 East) was selected because of the sample data provided by moonrocks brought back by the Apollo-12 astronauts. As Mrozek told Universe Today via email:

    The concept of utilizing a crater for construction holds considerable economic significance, as it diminishes the volume of structural materials needed by concentrating solely on the implementation of a cover. In the phase of our research presented in this paper, the specific location of the crater was not a primary focus. We selected a crater with dimensions appropriate for our design, situated in a region where the temperature range would facilitate the production of geopolymers without the need for supplementary energy.

    The authors analysed the concept of a covering lid for their hypothetical lunar crater, which measures 17 meters (~56 ft) in diameter and 6 meters (~20 ft) in depth. This is consistent with craters in the Mare Tranquillitatis region, which average about 20 meters by 8 meters (65.5 by 26.25 ft). The next step was to conduct a numerical analysis to identify the appropriate dimensions and shapes for a lunar structure that could handle the load transfers and maintain an Earth-like atmospheric pressure (1,013.25 millibars or 1 bar) within. The next step was to select building materials that could handle the internal stress distributions and be produced on-site using local resources.

    Ultimately, they selected lunar regolith-based geopolymers (GP), which consist of synthetic, inorganic monomers primarily composed of aluminium and silicon and have distinctive mechanical properties analogous to cement concrete. This is advantageous given that lunar regolith contains an average of 45% silicon oxide (SiO) by weight. The geopolymer they created consisted of a sodium hydroxide (NaOH) solution, sodium silicate water glass (NaO x nSiO x nHO), and the lunar highlands regolith simulant LHS-1 produced by Exolith Lab.

    Location of the site for the analysed structure—a hypothetical crater near a 0.67 latitude North and a 23.47 longitude East within the selenographic coordinate system. Credit: NASA Location of the site for the analysed structure—a hypothetical crater near a 0.67 latitude North and a 23.47 longitude East within the selenographic coordinate system. Credit: NASA

    “The creation of building materials from original lunar regolith is not a viable option; therefore, one of the available lunar regolith simulants on the market must be used,” said Mrozek. “We selected LHS, produced by Space Resource Technologies. Utilizing this material, we developed a geopolymer, which was subsequently tested to obtain the strength parameters that were input into the numerical model. The forces acting on a lunar structure differ significantly from those experienced on Earth; consequently, we needed to abandon certain methodologies applicable on Earth and re-examine the problem from a novel perspective.

    The curing conditions for the samples were subjected to were selected to simulate lunar conditions in the Mare Tranquillitatis region. While temperatures range from 120 °C during lunar day and -180 °C during lunar night (248 to -292 °F), they do not drop below 60 °C (140 °F) for seven terrestrial days, which is conducive to the geopolymerisation process. With these considerations in mind, the team cured their samples in a thermal vacuum chamber at 60 °C and a pressure of 50 hPa (50 millibars), consistent with the near-vacuum conditions on the Moon.

    After a total curing period of 28 days, the materials were subjected to bending and compression tests and analyzed using electron microscopy (SEM) and X-ray diffraction (XRD). These tests revealed that their regolith-based geopolymer had strength and elasticity comparable to masonry cement-sand calcium-silicate. The geopolymer and the design they selected could very well enable the construction of lunar bases in cratered mare regions, thus realizing a key goal of NASA’s Artemis Program. Said Mrozek:

    We are civil engineers, which is why our paper concentrates on this specific area of inquiry. However, we are currently collaborating with a diverse range of specialists from various countries in disciplines such as architecture, physics, geology, and chemistry. We are currently engaged in preparations for the initiation of a project of a lunar base, which will be significantly more complex and detailed.

    Further Reading: Nature

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  • Real-World Data Highlight Patient-Reported Benefits of Intranasal Zavegepant for Acute Migraine

    Real-World Data Highlight Patient-Reported Benefits of Intranasal Zavegepant for Acute Migraine

    In a real-world study conducted at the Cleveland Clinic, patients using 10-mg intranasal zavegepant (Zavzpret; Pfizer) for acute migraine reported meaningful pain relief, improved daily functioning, and high willingness to reuse the therapy through the validated migraine treatment optimization questionnaire-5 (MTOQ-5).1

    Presented at the 2025 American Headache Society (AHS) Annual Meeting, lead author Eric Dunn, DO, a neurologist at Cleveland Clinic, and colleagues evaluated patient-reported outcomes of individuals using 10-mg intranasal zavegepant for acute migraine treatment. Overall, the drug exemplified encouraging results, including benefits on pain relief, functional improvement, and a high willingness to reuse. The data, which involved patient responses to the MTOQ-5, a validated instrument for measuring migraine treatment optimization, offer an early glance at the effectiveness and tolerability of this third-generation calcitonin gene-related peptide (CGRP) receptor antagonist in clinical practice.

    The study population was 90% female with a mean age of 46.6 years (range 20-83) and a mean BMI of 29.1 kg/m2. Each patient received 9 doses, on average. As for acute efficacy, 45.0% of patients reported achieving complete pain relief within 2 hours of treatment at least half the time, 28.3% reported this benefit less than half the time, and 26.7% never achieved pain relief within that timeframe.

    Zavegepant, approved in 2023, is a third-generation, non-oral, intranasal CGRP antagonist designed to offer a rapid-acting alternative to oral medications for acute migraine. Although a phase 3 clinical trial already demonstrated its safety and efficacy, questions remained regarding its consistency and tolerability in real-world use. Thus, the retrospective study, presented at the 2025 American Headache Society (AHS) Annual Meeting, aimed to fill that gap by assessing patient outcomes using validated and supplemental survey tools.

    “While clinical trials have shown zavegepant to be effective for acute migraine treatment, understanding how it performs in real-world settings is critical to guiding treatment decisions,” Dunn et al wrote.1 “Our findings suggest that patients are experiencing meaningful relief and functional improvement with this therapy outside of controlled trial environments.”

    The analysis comprised patients who received at least two doses of 10-mg intranasal zavegepant. Of the 99 patients surveyed, 60 met eligibility and completed the MTOQ-5 and additional questions assessing pain relief, most bothersome symptom (MBS) resolution, and use of rescue medications, adverse effects, and overall satisfaction. Age, gender, race, and BMI were also included to further strengthen the data.

    A subset of patients experienced even more rapid relief: 28.3% reported being pain free within 31-60 minutes, and 16.7% in 30 minutes or less. Sustained relief, defined as pain freedom for at least 24 hours after 1 dose, was reported half the time or more by 43.3% of patients, less than half the time by 23.3%, and never by 33.3%.1

    READ MORE: Survey Data Highlights Real-World Use of Rimegepant for Short-Term Migraine Prevention

    Further findings around functionality indicated that zavegepant may help reduce the unpredictability of migraine attacks. Overall, 60.0% of patients reported returning to normal activities at least half the time after using the treatment, and 71.7% felt comfortable planning daily activities around the medication at least half the time.1

    CGRP contributes to pain and inflammation by widening blood vessels and transmitting pain signals. CGRP receptor antagonists, like zavegepant, work by blocking these receptors to interrupt that process and relieve symptoms. With its 2023 approval, zavegepant became the first CGRP antagonist available as a nasal spray, allowing for fast absorption and quick relief. The drug acts consistently across patients on a biological level, but factors like attack severity, timing of use, and individual variation influence how often patients experience noticeable relief.2

    Migraine affects nearly 2.81 billion people worldwide, with a steadily rising global burden and it has significant impact on daily functioning and quality of life, particularly among females of reproductive age. Despite the availability of preventive and acute therapies, many patients continue to suffer breakthrough attacks, variable treatment response, and persistent interictal disruptions that interfere with work, relationships, and emotional well-being.3

    These real-world findings support the potential use of zavegepant as part of a broader “toolbox” approach to migraine care, especially for patients seeking fast-acting, non-oral treatments like this one. The authors note that while these early results are promising, further studies with larger patient populations and extended follow-up are needed to better understand the long-term role of the drug in clinical practice. As the first retrospective study using MTOQ-5 to assess real-world outcomes of intranasal zavegepant, this work meaningfully contributes to the growing body of evidence on CGRP-targeted therapies.

    “Further real-world follow-up with larger sample sizes are needed to validate these findings,” the investigators noted. “Long-term implications of real-world outcomes will help better define the role of zavegepant within the toolbox approach of therapeutics.”1

    REFERENCES:
    1.Dunn E, Mays M, Ong B, et al. Real-world outcomes of zavegepant use in a tertiary care setting using Migraine Treatment Optimization Questionnaire-5 (MTOQ-5). Presented at: Frontier (P-261), American Headache Society Annual Scientific Meeting; 2025; Cleveland Clinic, Cleveland, OH.
    2.Flavin B. Mind over migraine: Disease burden, innovative therapies, and managed care trends in treating migraine disease. Journal of Managed Care & Specialty Pharmacy. 2025;31(7-a Suppl):S1-S13. doi:https://doi.org/10.18553/jmcp.2025.31.7-a.s1
    3.Wattiez AS, Sowers LP, Russo AF. Calcitonin gene-related peptide (CGRP): role in migraine pathophysiology and therapeutic targeting. Expert Opinion on Therapeutic Targets. 2020;24(2):91-100. doi:https://doi.org/10.1080/14728222.2020.1724285

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  • Britney Spears’ Kids: Everything to Know About Sons Sean and Jayden

    Britney Spears’ Kids: Everything to Know About Sons Sean and Jayden

    In 2023, Britney Spears dedicated her memoir, “The Woman in Me,” to the loves of her life — her kids.

    The pop icon, 43, shares two sons with her ex-husband, Kevin Federline: Sean Preston Federline, 19, and Jayden James Federline, 18.

    Although Federline was given full custody in 2008, Spears has recently gushed about her grown-up sons and shared updates about them on social media.

    Here’s everything you need to know about Sean and Jayden.

    Spears gave birth to her eldest son, Sean Preston, four days before her and Kevin Federline’s first wedding anniversary


    Britney Spears and Kevin Federline in 2005.

    Britney Spears and Kevin Federline in 2005 before the birth of their first child.

    Jeffrey Mayer/WireImage/Getty Images



    Three months after they met, Spears married rapper and dancer Kevin Federline on September 18, 2004, at a private home in Studio City, California.

    Spears told People shortly after the wedding that she was excited to be a mother. “I can see myself as a mom. Next year, at 23, I am so there,” she said at the time.

    On September 14, 2005, four days before the couple’s first wedding anniversary, Spears gave birth to a son, Sean Preston. 

    At the time, Federline had two children with his ex-partner, Shar Jackson, whom he separated from in 2004.

    While Sean’s birth marked the arrival of Spears’ first child, it wasn’t her first pregnancy. The “Crossroads” star revealed in her memoir that she had an abortion while dating Justin Timberlake between 1999 and 2002.

    Spears and Federline’s second son, Jayden James, was born a year later

    Eight weeks after Spears gave birth to Jayden on September 12, 2006, she filed for divorce from Federline, citing irreconcilable differences.

    They reached an initial divorce settlement in March 2007, agreeing to share custody of their children.

    However, according to People, Federline resisted signing the papers over concerns about Spears’ behavior. At the time, the “Toxic” singer was in rehab. They eventually finalized the divorce in July of that year.

    Federline was given full custody of the children after Spears’ public breakdown in 2007

    After making headlines for shaving her head and swinging an umbrella at paparazzi — both of which were caught on camera — Federline was given temporary custody of the couple’s sons by an LA court in October 2007.

    In January 2008, People reported that Spears was put on lockdown for a mental evaluation after locking herself in a room with her youngest son, Jayden. The Los Angeles court awarded sole custody to Federline and suspended Spears’ visitation rights. 

    In February 2008, the “Circus” singer’s father petitioned a court to place Spears under a temporary conservatorship. This became permanent in October of the same year.

    Spears made her first and only red carpet appearance with her sons in 2013

    After the event, she posted on X, then known as Twitter: “Awww! #Smurfs2 was super cute. The boys loved it.”

    Sean and Jayden also accompanied their mom to the 2015 Teen Choice Awards, where they took photos backstage with Spears’ style icon award.


    Britney Spears with her niece, Maddie, sons, Sean and Jayden, and brother, Bryan, at the 2015 Teen Choice Awards.

    Britney Spears with her niece, Maddie, sons, Sean and Jayden, and brother, Bryan, at the 2015 Teen Choice Awards.

    Steve Granitz/WireImage



    In 2016, Spears penned a tribute to her boys and called them her ‘masterpieces’

    For a short essay published in Time, Spears wrote about her love for her sons.

    “You are my masterpieces. From the day I saw the most precious eyes, I believed in miracles to the core. Such a gift God has given me, exploring in your beautiful worlds every day,” she wrote.

    “I pray as a mother I teach you strength and passion to carry through the struggles in the world,” she continued.

    Spears has continued to gush about her sons in social media posts

    On her Instagram page, Spears has shared many photos and captions dedicated to her boys.

    In August 2019, she commemorated their trip to Disneyland with a photograph of the three of them smiling in the amusement park.

    “Great time at Disneyland today,” she wrote. “My boys are older now, so they don’t like their picture taken ever … so I was thrilled today when they said SURE !!!!! Such a great place !!!!!”

    In March 2021, she shared another photo of the three of them standing in a field at sunset. In the caption, she marveled at how tall they both were getting.

    “It’s so crazy how time flies …. My boys are so big now,” she wrote in part. “I’m extremely lucky because my two babies are such gentleman and so kind that I must have done something right 🙊 !!!! I haven’t posted pictures of them for some time cause they’re at the age where they want to express their own identities and I totally get it.” 

    Sean and Jayden skipped Spears’ wedding to Sam Asghari in June 2022

    At the time, an attorney for their father told People the boys didn’t want to take the spotlight from their mother by attending, but were “happy” for the married couple.

    However, three months later, Jayden said during an interview with “60 Minutes Australia” that he felt uncomfortable accepting his mom’s invitation because she hadn’t invited other members of the family.

    “I’m really happy for them, but she didn’t invite the whole family,” the teenager said. “And then if it was just gonna be me and Preston, I just don’t see how that situation would have ended on good terms.” (Spears and Asghari divorced in 2023.)

    In September 2022, Jayden said that his relationship with his mom could be ‘fixed’ if she gets ‘better mentally’

    Speaking to ITV News, Spears’ youngest son explained why he and his brother didn’t go to their mom’s wedding.

    “At the time, it just wasn’t a good time to go. I’m not saying that I’m not happy for her,” Jayden said.

    The teenager said in the interview that his relationship with his mom “100%” could be “fixed.”

    “It’s just going to take a lot of time and effort. I just want her to get better mentally,” he continued. “When she gets better I really want to see her again.”


    Sean Federline, Jayden Federline, Britney Spears and Sam Asghari attend a basketball game at Staples Center on November 29, 2017.

    Sean Federline, Jayden Federline, Britney Spears, and Sam Asghari attend a basketball game in 2017.

    Allen Berezovsky / Getty Images



    Later that month, Spears said ‘a huge part’ of her died when she lost custody of her sons

    Less than two weeks after Jayden’s comments, Spears shared a series of audio clips on Instagram, including one in which she spoke about her sense of loss after losing custody of her children.

    “From when they were 6 to 9 years old, I had them 70% of the time, and of course, since they’ve been gone, I’ve honestly felt like a huge part of me has died,” she said in one of the clips. 

    “Like, literally, have no purpose anymore. They were my joy. They were my everything. I looked forward to seeing them. That was what I lived for and then all of sudden they were gone and I was like, ‘Did my heart just stop beating?’”

    In the summer of 2023, Sean and Jayden moved from Los Angeles to Hawaii with their father

    In May, Federline’s lawyer, Vincent Kaplan, told People that Spears had “consented” to Sean and Jayden moving to Hawaii with their father and his wife, Victoria Prince.

    Kaplan said the boys were “ready to get away from the LA microscope,” and that the move to Hawaii was a great opportunity for them to do so.

    In her memoir, Spears writes that she stopped challenging her conservatorship so that she could spend time with her children

    In “The Woman in Me,” Spears recalls her experience under her court-ordered 13-year conservatorship and why she decided to go along with it following her hospitalizations.  

    “After being held down on a gurney, I knew they could restrain my body any time they wanted to. And so I went along with it,” she writes.

    Spears writes that she complied so as not to ruin her chances of seeing her sons.

    “My freedom in exchange for naps with my children — it was a trade I was willing to make,” Spears writes.

    In 2024, Sean and Jayden spent Christmas with their mom

    The year after her memoir was published, Spears shared that she had the “best Christmas of my life” alongside a video with her sons.

    “I haven’t seen my boys in 2 years !!! Tears of joy and literally in shock everyday koo koo crazy so in love and blessed !!!” Spears wrote on Instagram. “I’m speechless thank you Jesus !!!”

    Spears has continued to gush about her sons on social media, calling them “incredibly sweet and charming” in a post from April 2025. “Mamas don’t get enough credit at all these days !!! I mean just saying !!! I made a person !!! A live breathing person and I made two of them !!!” she wrote.


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  • Avutometinib/Defactinib Display Safety, Efficacy in Ovarian Cancer Subtype

    Avutometinib/Defactinib Display Safety, Efficacy in Ovarian Cancer Subtype

    Among patients treated with the combination therapy, the median progression-free survival was 12.9 months.

    Avutometinib in combination with defactinib (Avmapki Fakzynja Co-Pack) exhibited a tolerable safety profile and enhanced efficacy vs avutometinib alone in patients with recurrent low-grade serous ovarian cancer (LGSOC), according to findings from the phase 2 RAMP 201 (NCT04625270) trial published in the Journal of Clinical Oncology.1

    Efficacy data revealed that the objective response rate (ORR) among patients treated with the combination was 31% vs 17% among those treated with avutometinib monotherapy. Furthermore, 29% achieved a partial response (PR) and 2% achieved a complete response (CR) in the combination arm vs 16% and 1%, respectively, in the avutometinib monotherapy arm.

    The median time to confirmed response in the combination arm was 3.7 months (range, 1.7-19.2), with a median duration of response (DOR) of 31.1 months (95% CI, 14.8 to 31.1). Furthermore, among responders in the combination arm, 81% (95% CI, 62%-91%) maintained a response at 6 months and 72% (95% CI, 54%-89%) maintained a response at 12 months.

    A planned subgroup analysis showed that the confirmed ORR among those treated with a prior MEK inhibitor was 24% (95% CI, 9%-45%) vs 33% (95% CI, 23%-44%) who were not treated with one. Additionally, the confirmed ORR was 20% (95% CI, 10%-33%) among those treated with prior bevacizumab (Avastin) vs 43% (95% CI, 29%-57%) who did not receive prior bevacizumab. Furthermore, the confirmed ORR was 24% (95% CI, 13%-39%) among those who received more than 3 prior lines of therapy vs 37% (95% CI, 25%-50%) among those who received 1 to 3 prior lines of therapy.

    Among patients treated with the combination therapy, the median progression-free survival (PFS) was 12.9 months (95% CI, 10.9-20.2). Among patients with KRAS-mutant disease, the median PFS was 22.0 months (95% CI, 11.1-36.6), and among those with KRAS wild-type disease, it was 12.8 months (95% CI, 7.4-18.4). For all patients, the 6- and 12-month PFS rates were 79% (95% CI, 70%-86%) vs 58% (95% CI, 47%-68%).

    “The publication of the primary analysis of the [phase 2] RAMP 201 study in recurrent low-grade serous ovarian cancer in the Journal of Clinical Oncology reflects the meaningful clinical advancement demonstrated by the combination of avutometinib plus defactinib for patients with recurrent low-grade serous ovarian cancer,” John Hayslip, MD, chief medical officer at Verastem Oncology, said in a news release on the publication2. “The findings supported the recent FDA approval of the combination in KRAS-mutated recurrent low-grade serous ovarian cancer and our ongoing global phase 3 RAMP 301 (NCT06072781) trial of the combination in recurrent low-grade serous ovarian cancer with and without a KRAS mutation.”

    Patients 18 years and older with histologically confirmed low-grade serous ovarian cancer (LGSOC) were initially randomly assigned 1:1 to receive avutometinib/defactinib or avutometinib monotherapy in parts A and B of the trial. In part C, the combination was identified as the go-forward regimen and expanded, and in part D, a lower dose of avutometinib was assessed in combination with defactinib.

    Patients in the combination arm received oral avutometinib at 1.6 mg or 3.2 mg twice weekly and 200 mg of oral defactinib twice daily for 3 weeks, followed by a 1-week rest period for a 4-week cycle. Patients in the monotherapy arm received 4.0 mg oral avutometinib twice weekly for 3 weeks, followed by a 1-week rest period.

    Those in the combination (n = 115) and monotherapy (n = 70) arms had a median age of 54 years (range, 21-87) and 54 years (range, 21-77), 77% vs 84% were White, and 68% vs 71% had an ECOG performance status of 0. The median number of systemic therapies received in each arm was 3 (range, 1-9) and 3 (range, 1-10), 99% vs 99% received prior platinum-based chemotherapy, and 86% vs 83% received prior hormonal therapy. In each respective arm, the receipt of prior bevacizumab was observed in 51% vs 49% of patients, and the receipt of prior MEK inhibition was observed in 22% vs 26%.

    The primary end point of the study was ORR per RECIST v1.1 as assessed by blinded independent committee review. Secondary end points included DOR, investigator-assessed ORR, PFS, overall survival, safety, and pharmacokinetics.

    Safety data revealed that the most frequently reported treatment-related adverse effects (TRAEs) included nausea (67%), diarrhea (58%), peripheral edema (53%), rash (50%), fatigue (44%), and vomiting (43%). The most frequent TRAEs at grades 3 or 4 in severity included diarrhea (8%), anemia (5%), and dermatitis acneiform (4%). Additionally, treatment-related increased creatine phosphokinase (CPK) occurred in 60% of patients, with 19% experiencing grade 3 events and 5% experiencing grade 5 events.

    AEs leading to treatment discontinuation occurred in 10% of patients; the most common of which came from elevated CPK in 4% of patients. Additionally, treatment-related skin reactions occurring in at least 20% of patients included rash (50%), dermatitis acneiform (34%), and dry skin (26%), with most being grade 1 or 2 in severity. Treatment-related serious AEs occurred in 7% of patients, and 5 deaths were observed in the combination arm, all of which were not considered related to study treatment.

    References

    1. Banerjee SN, Nieuwenhuysen EV, Aghajanian C, et al. Efficacy and safety of avutometinib ± defactinib in recurrent low-grade serous ovarian cancer: primary analysis of ENGOT-OV60/GOG-3052/RAMP 201. J Clin Oncol. doi:10.1200/JCO-25-00112
    2. Verastem Oncology announces publication of the primary results from the phase 2 RAMP 201 trial of avutometinib in combination with defactinib in patients with recurrent low-grade serous ovarian cancer in the Journal of Clinical Oncology. News release. Verastem Oncology. July 11, 2025. Accessed July 14, 2025. https://tinyurl.com/2r4v3pbe

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  • Google Melding Chrome OS and Android Into One Platform

    Google Melding Chrome OS and Android Into One Platform

    In a conversation with TechRadar published Friday (July 11), Sameer Samat, president of the Android Ecosystem at Google, asked reporter Lance Ulanoff why he was using a MacBook Pro, Apple Watch and iPhone to understand about the apps he uses to manage these devices.

    “I asked because we’re going to be combining ChromeOS and Android into a single platform, and I am very interested in how people are using their laptops these days and what they’re getting done,” Samat said.

    The report notes that this has been a big year for Android, with the ecosystem recently unveiling its Android 16, which Samat says was the platform’s “biggest design change in Android in three or four years.”

    As PYMNTS wrote in May, the phone’s update includes a design called Material 3 Expressive, phones and watches using Google’s operating system will be “more fluid, personal and glanceable,” as Mindy Brooks, vice president of product management and user experiences, Android platform, wrote in a company blog post.

    In addition, the Tech Radar report discussed the combination of Android phones with Google’s Gemini artificial intelligence (AI) model.

    Calling it “that Gemini Experience,” Samat says users who switch from other phones are “seeing over and over again what they’ve been missing.”

    He demonstrated how Gemini could both summarize a long YouTube video and break down its claims (with time stamps) by using in sources from the Web, something Tech Radar described as Gemini “leaning into its Google search roots.”

    “What I’m getting at,” Samat said, “is that Gemini integrated in a phone really provides a much more helpful experience. And when consumers do move over from an iPhone, they instantly realize that they’ve been missing a lot of this.”

    PYMNTS looked at the state of AI-powered search — as well as the possible future of Google — in a recent interview with Adam Behrens, CEO of retail AI tech startup New Generation.

    He argued that in five years, Google won’t be “a list of links,” but “a service where you get answers, then actions, which changes how people shop and what they expect.”

    “The traditional ad model starts to break down because there’s less screen space and fewer choices; you either show up ready to be picked, or you’re invisible,” Behrens added.

    “For brands, it means they can’t just live behind a website anymore. They need to show up across the entire AI ecosystem so they’re shoppable, searchable and ready for whatever agent your customer is using.”

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  • 2026 IHF Men’s and Women’s Beach Handball World Championships – qualification update

    Following the conclusion of the 2025 EHF Men’s and Women’s European Beach Handball Championships in Türkiye, and the Asian championships earlier this year, more than half (19) of the 32 teams for the 2026 IHF Men’s and Women’s Beach Handball World Championships in Croatia next year are known.

    Based on the results of the 2024 IHF Men’s and Women’s Beach Handball World Championships held in the People’s Republic of China last year, the following places are allocated for the 2026 edition per Continental Confederation, in addition to the host nation and current world champions.

    • Men’s competition: Africa (1 place), Asia (2), Europe (7), Oceania (1), South and Central America (2), North America and the Caribbean (2)
    • Women’s competition: Africa (1), Asia (2), Europe (5), Oceania (1), South and Central America (3), North America and the Caribbean (2)

    Continental Confederations have until 30 September 2025 to confirm their allocated places. If a qualified federation does not confirm its right to participate, the IHF Executive Committee will take a final decision on the substitute nations. All continental qualifications must take place no later than 31 March 2026.

    Alongside hosts and current men’s world champions Croatia (10 appearances – ever-presents), the European championship saw Germany (2), Spain (9), Hungary (7), Portugal (2) and Denmark (5) qualify for another global event thanks to their EURO ranking. 

    But for Italy and France, their finish in Alanya meant history – Croatia 2026 will be their first-ever senior men’s world championship appearance.

    Pasquale Maione’s Italian team finished eighth, but that was enough to finally make it to the world stage. 

    “Qualifying for the next world championships is an historic achievement and is the result of the dedication of all the players – we’re delighted,” said coach Maione to Federhandball.it.

    “We thank all the fans who have shown us their warmth and support from home. This can only be a motivation for us to continue working with even greater determination and strive to arrive at the world championship in the best possible condition.”

    For France, known as ‘Les Bleus’, their fifth-place finish at the EURO means they will finally join the French women – who have one world championship appearance in 2018 to their name – on the world stage.

    Coach Paul Mourioux led the French men to that top five finish – the best-ever continental senior finish for either team – and he and his captain, Alexix Gilme, could not be more pleased.

    “I am very proud of the work done by the team and very happy with this result,” said Mourioux to FFHandball.fr, with Gilme looking to the future already. “It is truly the fruit of an immense collective effort and I also count the absentee players, who have worked on this season and sometimes on those that preceded it,” he said. “There is no doubt that this collective will continue to move forward in the months and years to come.”

    In the women’s competition, alongside hosts Croatia and current world champions Germany, who already qualified, 2016 world champions Spain (7 appearances), 2010 winners Norway (8), double bronze medallists Netherlands (2), double silver medallists Denmark (6) and 2018 champions Greece (3) all booked spots for Croatia 2026.

    After the organising rights for the 2026 IHF Men’s and Women’s Beach Handball World Championships were awarded to the Croatian Handball Federation, following the decision taken by the IHF Council on 18 June 2025, thoughts have turned to the event which will take place next year, with venue and competition dates to be confirmed in due course.

    2026 will be the first time Croatia hosts the IHF Men’s and Women’s Beach Handball World Championships and comes after the nation was a co-host of the 2025 IHF Men’s World Championship earlier this year.

    “The right to organise the IHF Men’s and Women’s Beach Handball World Championships in Croatia is very good news that confirms our country’s long-standing dominance in beach handball on a global scale and is a great incentive for further development and investment in this sport,” said Croatia’s women’s team captain Kristina Smiljanic about the event.

    “I believe that Croatia has been deservedly, fully, put on the world map, where our national teams and clubs are at the top of European and global beach handball. It is the right time for our national scene to be further elevated through these world championships.

    “This will be a very nice event in front of the domestic audience who will have the opportunity to see the most beautiful moves and styles of play through the attractive moves and dynamics of this sport,” she added.

    “Also, this is an opportunity that should be used to create an animation for the upcoming generations of future beach handball players. The pressure and expectations will certainly be very high, but this is just an additional motive and motivation that will push us towards a medal.”

    After the organising rights were announced, Chair of the IHF Beach Handball Working Group, Giampiero Masi, was full of praise about what the European nation can offer.

    “I’m sure it will mark a landmark moment in the beach handball evolution,” he said to ihf.info. “Croatia has long been a powerhouse in beach handball, has hosted numerous international competitions and the sport is really popular.

    “Croatians have influenced beach handball worldwide and have one of the most decorated beach handball teams in the world. They have all the conditions for a fantastic edition of the IHF Men’s and Women’s Beach Handball World Championships and I am sure it will be amazing.”

    2026 IHF Men’s and Women’s Beach Handball World Championships – qualified teams
    as of 14 July 2025

    Women’s competition
    1. Hosts: Croatia
    2. Reigning World Champions: Germany
    3. AHF (Asia) Continental Place: Vietnam, 1st – Asian Championship
    4. AHF: Philippines, 2nd – Asian Championship
    5. EHF (Europe) Continental Place: Spain, 1st – EURO
    6. EHF: Norway, 2nd – EURO
    7. EHF: Netherlands, 4th – EURO
    8. EHF: Denmark, 5th – EURO
    9. EHF: Greece, 6th – EURO
    10. CAHB (Africa) Continental Place
    11. OCHF (Oceania) Continental Place
    12. SCAHC (South and Central America) Continental Place
    13. SCAHC (South and Central America) Continental Place
    14. SCAHC (South and Central America) Continental Place
    15. NACHC (North America and the Caribbean) Continental Place
    16. NACHC (North America and the Caribbean) Continental Place

    Men’s competition
    1. Hosts and Reigning World Champions:
    Croatia
    2. AHF: Oman, 1st – Asian Championship
    3. AHF: Islamic Republic of Iran, 1st – Asian Championship
    4. EHF: Germany, 1st – EURO
    5. EHF: Spain, 2nd – EURO
    6. EHF: Hungary, 4th – EURO
    7. EHF: France, 5th – EURO
    8. EHF: Portugal, 6th – EURO
    9. EHF: Denmark, 7th – EURO
    10. EHF: Italy, 8th – EURO
    11. CAHB (Africa) Continental Place
    12. OCHF (Oceania) Continental Place
    13. SCAHC (South and Central America) Continental Place
    14. SCAHC (South and Central America) Continental Place
    15. NACHC (North America and the Caribbean) Continental Place
    16. NACHC (North America and the Caribbean) Continental Place

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  • Cristhian Mosquera transfer news: Arsenal agree deal to sign Valencia defender | Football News

    Cristhian Mosquera transfer news: Arsenal agree deal to sign Valencia defender | Football News

    Arsenal have agreed a deal with Valencia worth an initial £13m plus add-ons for defender Cristhian Mosquera.

    Personal terms on a five-year deal have also been agreed in principle.

    Mosquera is expected to fly into the UK in the next 24-48 hours for a medical and to finalise the move.

    Arsenal are hopeful all will be sorted in time for Mosquera to be part of the squad that flies out to Asia for the club’s pre-season tour on Saturday.

    Mosquera has effectively confirmed his departure from Valencia. “This is my home and it always will be,” he told Spanish radio station Radio Marca Valencia.

    “I arrived here at 12 years old and I’m leaving as a man. I’m a bit sad.”

    Arsenal’s summer window so far

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    Sky Sports’ Dharmesh Sheth and Mark McAdam are joined by Ashley Young as they discuss what is potentially holding up transfer negotiations between Sporting Lisbon and Arsenal for star striker Viktor Gyokeres.

    In

    Kepa Arrizabalaga – Chelsea, £5m

    Martin Zubimendi – Real Sociedad, £51m

    Christian Norgaard – Brentford, £15m

    Out

    Jorginho – Flamengo, free

    Kieran Tierney – Celtic, free

    Nuno Taveres – Lazio, £4.3m

    Marquinhos – Cruzeiro, undisclosed

    Takehiro Tomiyasu – released

    Thomas Partey – released

    Sky Sports to show 215 live Premier League games from next season

    Watch more Premier League matches on Sky Sports ever before with 215 games live of the 2025/26 Premier League season.
    Image:
    Watch more Premier League matches on Sky Sports ever before with 215 games live of the 2025/26 Premier League season.

    From next season, Sky Sports’ Premier League coverage will increase from 128 matches to at least 215 games exclusively live.

    And 80 per cent of all televised Premier League games next season are on Sky Sports.

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  • Two meteorites found in the Sahara could be from the solar system’s least studied planet, scientists say

    Two meteorites found in the Sahara could be from the solar system’s least studied planet, scientists say

    Researchers suspect that two meteorites found in the Sahara Desert in 2023 may originally have come from Mercury, which would make them the first identified fragments of the solar system’s innermost planet.

    The least studied and most mysterious of the solar system’s rocky planets, Mercury is so close to the sun that exploring it is difficult even for probes. Only two uncrewed spacecraft have visited it to date — Mariner 10, launched in 1973, and MESSENGER, launched in 2004. A third, BepiColombo, is en route and due to enter orbit around the planet in late 2026.

    Scientists know little about Mercury’s geology and composition, and they have never been able to study a fragment of the planet that landed on Earth as a meteorite. In contrast, there are more than 1,100 known samples from the moon and Mars in the database of the Meteoritical Society, an organization that catalogs all known meteorites.

    These 1,100 meteorites originated as fragments flung from the surfaces of the moon and Mars during asteroid impacts before making their way to Earth after a journey through space.

    Not every planet is likely to eject fragments of itself Earth-ward during collisions. Though Venus is closer to us than Mars is, its greater gravitational pull and thick atmosphere may prevent the launch of impact debris. But some astronomers believe that Mercury should be capable of generating meteors.

    “Based on the amount of lunar and Martian meteorites, we should have around 10 Mercury meteorites, according to dynamical modeling,” said Ben Rider-Stokes, a postdoctoral researcher in achondrite meteorites at the UK’s Open University and lead author of a study on the Sahara meteorites, published in June in the journal Icarus.

    “However, Mercury is a lot closer to the sun, so anything that’s ejected off Mercury also has to escape the sun’s gravity to get to us. It is dynamically possible, just a lot harder. No one has confidently identified a meteorite from Mercury as of yet,” he said, adding that no mission thus far has been capable of bringing back physical samples from the planet either.

    If the two meteorites found in 2023 — named Northwest Africa 15915 (NWA 15915) and Ksar Ghilane 022 (KG 022) — were confirmed to be from Mercury, they would greatly advance scientists’ understanding of the planet, according to Rider-Stokes. But he and his coauthors are the first to warn of some inconsistencies in matching those space rocks to what scientists know about Mercury.

    A fragment of Northwest Africa 15915, a meteorite found in 2023 that the study authors also believe could have originated from Mercury. – Jared Collins

    The biggest is that the fragments appear to have formed about 500 million years earlier than the surface of Mercury itself. However, according to Rider-Stokes, this finding could be based on inaccurate estimates, making a conclusive assessment unlikely. “Until we return material from Mercury or visit the surface,” he said, “it will be very difficult to confidently prove, and disprove, a Mercurian origin for these samples.”

    But there are some compositional clues that suggest the meteorites might have a link to the planet closest to the sun.

    Hints of Mercurian origins

    It’s not the first time that known meteorites have been associated with Mercury. The previous best candidate, based on the level of interest it piqued in astronomers, was a fragment called Northwest Africa (NWA) 7325, which was reportedly found in southern Morocco in early 2012.

    Rider-Stokes said that was the first meteorite to be potentially associated with Mercury: “It got a lot of attention. A lot of people got very excited about it.” Further analysis, however, showed a richness in chrome at odds with Mercury’s predicted surface composition.

    More recently, astronomers have suggested that a class of meteorites called aubrites — from a small meteorite that landed in 1836 in Aubres, France — might come from Mercury’s mantle, the layer below the surface. However, these meteorites lack a chemical compatibility with what astronomers know about the planet’s surface, Rider-Stokes said. “That’s what’s so exciting about the samples that we studied — they have sort of the perfect chemistry to be representative of Mercury,” he said.

    Most of what is known about Mercury’s surface and composition comes from NASA’s MESSENGER probe, which assessed the makeup of the planet’s crust from orbit. Both meteorites from the study, which Rider-Stokes analyzed with several instruments including an electron microscope, contain olivine and pyroxene, two iron-poor minerals confirmed by MESSENGER to be present on Mercury.

    The new analysis also revealed a complete lack of iron in the space rock samples, which is consistent with scientists’ assumptions about the planet’s surface. However, the meteorites contained only trace amounts of plagioclase, a mineral believed to dominate Mercury’s surface.

    A view of Mercury produced using images from MESSENGER's primary mission. - NASA/Johns Hopkins University Applied Physics Laboratory/Carnegie Institution of Washington

    A view of Mercury produced using images from MESSENGER’s primary mission. – NASA/Johns Hopkins University Applied Physics Laboratory/Carnegie Institution of Washington

    The biggest point of uncertainty, though, is still the meteorites’ age. “They are about 4.5 billion years old,” Rider-Stokes said, “and most of Mercury’s surface is only about 4 billion years old, so there’s a 500 million-year difference.”

    However, he said he thinks this discrepancy is not sufficient to rule out a Mercurian origin, due to the limited reliability of MESSENGER’s data, which has been also used to estimate the age of Mercury’s surface layer.

    “These estimates are based on impact cratering models and not absolute age dating, and therefore may not be entirely accurate,” Rider-Stokes said. “It doesn’t mean that these samples aren’t good analogs for regional areas on the surface of Mercury, or the early Mercurian crust that is not visible on the modern surface of Mercury.”

    With more modern instruments now available, BepiColombo, the European Space Agency probe that will start studying Mercury in early 2027, may be able to answer long-standing questions about the planet, such as where it formed and whether it has any water.

    Having material confirmed to have come from other planetary bodies helps astronomers understand the nature of early solar system’s building blocks, Rider-Stokes said, and identifying fragments of Mercury would be especially crucial since a mission to gather samples from the planet closest to the sun and bring them back would be extremely challenging and expensive.

    Clues to planet formation

    Sean Solomon, principal investigator for NASA’s MESSENGER mission to Mercury, said in an email that he believes the two meteorites described in the recent paper likely did not originate from Mercury. Solomon, an adjunct senior research scientist at Columbia University in New York City, was not involved with the study.

    The primary reason Solomon cited for his doubts is that the meteorites formed much earlier than the best estimates for the ages of rocks now on Mercury’s surface. But he said he thinks the samples still hold research value.

    “Nonetheless, the two meteorites share many geochemical characteristics with Mercury surface materials, including little to no iron … and the presence of sulfur-rich minerals,” he added. “These chemical traits have been interpreted to indicate that Mercury formed from precursor materials much more chemically reduced than those that formed Earth and the other inner planets. It may be that remnants of Mercury precursor materials still remain among meteorite parent bodies somewhere in the inner solar system, so the possibility that these two meteorites sample such materials warrants additional study.”

    Solomon also noted that it was difficult to persuade the planetary science community that there were samples from Mars in meteorite collections, and that it took precise matching of their chemistry with data about the surface of Mars taken by the Viking probes to convince researchers to take a closer look. Lunar meteorites were also not broadly acknowledged to be in meteorite collections until after the existence of Martian meteorites had been demonstrated in the 1980s, he added, even though the Apollo and Luna missions had returned abundant samples of lunar materials more than a decade earlier.

    Once samples are confirmed to be from a planetary body, Solomon said, they can provide crucial information not available from remote sensing by an orbiting spacecraft on the timing of key geological processes, the history of internal melting of the body, and clues to planet formation and early solar system processes.

    Rider-Stokes plans to continue the discussion around these meteorites at the annual meeting of the Meteoritical Society, which takes place in Perth this week. “I’m going to discuss my findings with other academics across the world,” he said. “At the moment, we can’t definitively prove that these aren’t from Mercury, so until that can be done, I think these samples will remain a major topic of debate across the planetary science community.”

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