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  • Alpine design boss talks motorsport, aerodynamics and the current era of car design

    Alpine design boss talks motorsport, aerodynamics and the current era of car design

    With the sun just starting to lose its sting and the backdrop of multiple new launches on the stand, not to mention the thumping music of Alpine’s resident DJ and overtones of muscle cars flinging themselves up the hill, it is safe to say Antony Villain was in good spirits during our interview at Goodwood 2025. 

    And why wouldn’t he be. The brand has worked not grown its portfolio from dedicated sportscars and hot hatches and now, with the A390, more of a premium fastback. Not only that, but also the broader motorsport efforts such as Alpenglow, the hydrogen-powered endurance hypercar that also found itself on the Goodwood paddock and track. Just over Villain’s shoulder is the A290 Rallye, too, a special edition created to mark the brand’s 70th anniversary. 

    Villain in front of the Alpine stand

    It is more than a show car, and has been designed to meet current rally regulations with an eye to mixing it in a range of competitions; any that will have it, essentially. A roll cage, bucket seats and all-important hydraulic handbrake form the trifecta of core rally components, while uprated suspension, braking and drivetrain (LSD anyone?) complete the package. Power is delivered to the front axle, so plenty of opportunity for Scandi flicks and more of a distinct driving dynamic compared to most all-wheel drive performance EVs. 

    It continues a theme. Alpine has clearly evolved for the modern era of the automotive industry and sells cars to the masses. It is a business. But alongside that it continues to champion its heritage in motor racing, recently launching the A110 GT4 which has gone on to race (and win) on the track. It’s a similar story with the A110 Rally and Rallye GT+ before it. 

    “We always have this mindset,” Villain tells Car Design News. “But of course, when you turn electric, things start to get tougher because there are not a lot of categories where you can fit. So with the A290, we wanted to do something around rallying as we felt the car could fit this kind of sport.” 

    You have to create your own momentum… I prefer designing now over 20 years ago

    Not every design director has the chance to turn money spinners into wheel spinners, and Villain is keenly aware of the opportunity he has taken with the French outfit: “When I was kid, I wanted to do this job. This was my dream. So now I don’t feel like I’m going to work. To be able to design these cars [A110, A290, A390) alongside the Alpenglow Hydrogen Le Mans car in the same workshop… It’s crazy.”

    Indeed, it seems the Alpenglow has been particularly exciting to work on even amid the media storm of the brand’s more recent launches. Here, the team managed to not only get a track weapon together but go off piste with how aerodynamic features were integrated and presented.  


    Alpenglow’s floating rear wing

    In essence, the plan was to create a rather different silhouette to what might usually be expected, utilising clear materials that from a distance or certain angles appear to be almost invisible. The floating rear wing (shown above) certainly seems a strong result and Villain is proud of the outcome. But it wasn’t easy. 

    “You need a lot of airflow into the body, so there are a lot of open areas, but you also need lots of downforce and low drag. Sometimes, we want to show something spectacular, so even with all of this in mind, we thought: let’s take the challenge to have a transparent wing and not this huge tall spoiler.” 

    The first effort was a 40kg block of milled polycarbonate – anything but light – and so the next iteration was built with real constraints in mind. This meant the strategy had to be evolved to meet targets for driving range, downforce and overall weight. “We optimised everything, added a metallic structure for the fixation point of the two arms into the polycarbonate, and ultimately engineered everything to be much lighter.” 

    The result is a wing that sits level with the rear wheel arches, further hiding it from view in side profile and front on. “That’s the masterpiece,” he continues. “We wanted to make it super subtle, super elegant and invisible. We’ve continued to work on it as well, because we really want to bring this to production; we already see some other manufacturers starting to play with that approach – I hope we inspired them – but I would be really happy if we were the first to put it into production.”

    Touching again on this period of his career in design, Villain gives a refreshing view on the current state of play as manufacturers lean more heavily into electrification, software and anything else that has disrupted the status quo. Rather than wishing they had been around different glory days over the decades, designers should celebrate where they are and embrace whatever they are faced with. 

    “You have to create your own momentum,” he emphasises. “You never stay where you are. You always look for the next challenge, the next idea. Of course, in the 70s or 60s you were able to design Le Mans cars, but with the new regulations we have the chance to redesign them. So okay, the guys from the 70s had the chance to do their things, but we have the same chance to do ours now; and with new technologies, new materials, new possibilities. You just have to enjoy it. There are a lot of challenges in the car industry, but that’s where creativity is needed. It’s the right momentum and, to be honest, I prefer designing now compared to 20 years ago.”

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  • RBC hikes year-end S&P 500 target as investors look to 2026 for gains

    RBC hikes year-end S&P 500 target as investors look to 2026 for gains

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  • Metformin in Metastatic Prostate Cancer

    Metformin in Metastatic Prostate Cancer

    By Matthew Stenger
    Posted: 7/14/2025 11:04:00 AM

    Last Updated: 7/14/2025 11:05:30 AM

    In a phase III trial (part of the STAMPEDE platform) reported in The Lancet Oncology, Gillessen et al investigated the survival outcomes of adding metformin to standard of care (SOC) in nondiabetic patients with metastatic hormone-sensitive prostate cancer starting androgen-deprivation therapy (ADT). 

    Study Details

    In the open-label trial, 1,874 patients from sites in the United Kingdom and Switzerland were randomly assigned between September 2016 and March 2023 to receive SOC (n = 938) or metformin at 850 mg twice daily plus SOC (n = 936). Standard of care consisted of ADT with or without radiotherapy and with or without docetaxel or an androgen receptor pathway inhibitor (ARPI; docetaxel vs abiraterone, enzalutamide, or apalutamide). The primary endpoint was overall survival.

    Key Findings

    Median time to most recent patient follow-up was 60 months (interquartile range [IQR] = 49–72 months). Median overall survival was 67.4 months (IQR = 32.5 months to not reached) in the metformin-SOC group vs 61.8 months (IQR = 29.7 months to not reached) in the SOC group  (hazard ratio [HR] = 0.91, 95% confidence interval [CI] = 0.80–1.03, P = .15).

    Grade ≥ 3 adverse events occurred in 57% of the metformin-SOC group vs 52% of the SOC group, with grade ≥ 3 gastrointestinal adverse events in 9% vs 7%; no differences in grade ≥ 3 events in other body systems were observed.

    Weight gain was significantly lower in the metformin-SOC group at 24, 48, and 104 weeks (all P < .0001). Among 583 patients with body weight data available at baseline and at 104 weeks, those in the metformin-SOC group gained a mean of 2.00 kg (95% CI = 1.31–2.69 kg) vs 4.40 kg (95% CI = 3.57–5.24 kg) in the SOC group (mean difference = –2.48 kg, 95% CI = –3.55 to –1.41 kg).

    The investigators concluded: “We did not find significant evidence of an overall survival benefit of adding metformin to SOC in the overall population of patients with metastatic hormone-sensitive prostate cancer. The side-effect profile of metformin was as expected and consisted mainly of diarrhea. Adverse metabolic side effects of ADT were significantly reduced in the metformin group compared with the standard of care group.”

    Silke Gillessen, MD, of the Institute of Oncology of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona, is the corresponding author for The Lancet Oncology article.

    Disclosure: The study was funded by Cancer Research UK, Prostate Cancer UK, and UK Research and Innovation Medical Research Council. For full disclosures of all study authors, visit The Lancet Oncology.

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  • Preorder Sideshow’s Pokédex-Size Pikachu Statue Now

    Preorder Sideshow’s Pokédex-Size Pikachu Statue Now

    Collectible company Sideshow is teaming up with Pokémon to create a new line of collectible statues, the first of which is a Pokédex-size version of Pokémon #0025, Pikachu. The lovable Mouse Pokémon will be brought to life as a stunning figure that perfectly captures its cuteness and personality. From its bright red cheeks to its distinctive lightning bolt-shaped tail, this high-end collectible will make you feel like the iconic Pokémon is hanging out in your home.

    The Pikachu Life-Size Figure measures 18.5 inches tall (including its base) and 17.6 inches wide, with a circular base that’s 9.8 inches deep. At that size, this beautiful statue is sure to amp up your Pokémon collection. You can preorder this Pikachu statue now—directly from Sideshow.

    If you can’t get enough of Sideshow’s incredible statues, prepare for the next entry in its Pokémon collection: a Charizard statue that is scaled to a perfect size for display. Stay tuned for more information about this tribute to the popular Flame Pokémon.

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  • Barça Legends to play in Monterrey, Mexico

    Barça Legends to play in Monterrey, Mexico

    Summer holidays over, Albert Ferrer’s Barça Legends team will travel to Mexico to take on a Tigres Leyendas team in the city of Monterrey. The game will be on 31 August, kick off 6pm local time (2am CEST the following day) in the Estadio Universitario, known as ‘El Volcán’, which holds 42,000 fans. For the game players such as Andrés Iniesta, David Villa and Rafa Márquez will be available, the latter now assistant coach to a Mexican national side who recently claimed the CONCACAF Gold Cup. 

    The rest of the Barça squad for the game against the Mexican legends side will be named in the coming weeks. Tigres are one of the most famous clubs in Mexico and have won the league title on eight occasions, most recently in 2023. The Leyendas side will contain former Tigres players Lucas Lobos, Jesús Dueñas, Rafael Sobis, Juninho, Hugo Ayala, Israel Jiménez and Egidio Arévalo.

    Who are the Barça Legends 

    Barça Legends is a Club-managed programme that was created in 2016 to integrate former Barça players into a permanent professional project with the Club to help spread the Barça brand and present the Club’s values around the world. Over 80 players have participated in at least one match since Barça Legends began.

     

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  • Volleyball and beach volleyball competition schedule confirmed for Olympic Games LA28 

    With just three years to go until the Olympic Games LA28, the LA28 Organising Committee has officially confirmed the competition schedule and format for volleyball and beach volleyball. Both sports are set to shine once again as part of the Games programme which will take place from 14-30 July 2028.

    As previously announced, beach volleyball will be held at Alamitos Beach in the City of Long Beach, a designated LA28 Venue City. This stunning seaside location promises a spectacular backdrop for one of the Olympic Games’ most thrilling and visually iconic events. Volleyball will be held at the Anaheim Arena, a premier entertainment and sports venue that will undoubtedly provide a great Olympic stage for an unforgettable volleyball experience.

    For beach volleyball, the Preliminary Rounds will take place from Saturday 15 to Saturday 22 July, with three sessions per day for both the men’s and women’s competitions (excluding Saturday 22 July where there will be two sessions). The R16 will occur on Sunday 23 to Monday 24 July inclusive, with four sessions in each competition.

    Quarter finalists will battle it out on Tuesday 25 and Wednesday 26 July with both an afternoon and an evening session, before the semi-finalists in both competitions go head-to-head on Thursday 27 July. The men’s and women’s beach volleyball champions will be crowned on the evenings of Friday, 28 July and Saturday, 29 July.

    For volleyball, the Preliminary Rounds are set to begin on the same day as beach volleyball, Saturday 15 July, and end on Sunday 23 July. Each day of the Preliminary Rounds will include four sessions for both the men’s and women’s competitions.

    Quarter Finals for both competitions will take place across four sessions on Monday 24 and Tuesday 25 July before the final four teams in each gender battle it out in the semifinals on Wednesday 26 July and Thursday 27 July. The men’s and women’s bronze and gold medal matches will take place across Friday 28 July through Sunday 30 July which will mark the final volleyball match of the Olympic Games LA28.

    This announcement follows the extraordinary success of the Olympic Games Paris 2024, widely hailed as one of the most successful Games ever for volleyball and beach volleyball. From record-breaking global viewership to world-class performances and iconic settings, the sport captivated global audiences and solidified its status as a fan favourite.

    The FIVB will continue working closely with the LA28 Organising Committee to support the delivery of a truly memorable few weeks for the Global Volleyball Movement.

    *Please note that, as with previous Games, this provisional competition schedule will remain subject to change through to Games-time in 2028. Later this year, LA28 will release a more detailed competition schedule outlining the specific gender order for each tournament for the 2028 Games.

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  • The Deeper Meaning Behind Kate Middleton’s Dazzling New Ring Stack

    The Deeper Meaning Behind Kate Middleton’s Dazzling New Ring Stack

    When the Princess of Wales returned to royal duties following chemotherapy treatment last year, fans quickly clocked that she had added a new eternity ring to her collection, believed to be Cartier’s Étincelle de Cartier wedding band. Over the past year, Kate has often been photographed wearing the $6,300 platinum ring, comprising 19 brilliant-cut diamonds and 19 brilliant-cut sapphires, in lieu of her more famous 12-carat oval-cut Ceylon sapphire engagement ring, which Prince William inherited from Princess Diana following her death.

    There was much discussion about why the Princess was wearing her new Cartier ring—often paired with her wedding band and another diamond eternity ring, believed to have been gifted by William to mark Prince George’s birth in 2013—instead of her larger engagement ring. Perhaps it was simply a more everyday choice (Kate has tended to wear the latter at more formal events, such as last year’s Festival of Remembrance at Royal Albert Hall.)

    The Princess of Wales wore her two eternity bands with her 12-carat oval-cut Ceylon sapphire engagement ring for the first time at Wimbledon over the weekend.

    Photo: Getty Images

    But at Wimbledon at the weekend, Kate wore her engagement ring with both of her eternity rings, as well as her wedding band, for the first time. It comes as ring stacking is becoming increasing popular—particularly among new brides. “We’re increasingly seeing clients choose to style their eternity ring stacked with their engagement ring and wedding band, or wear it alone for a more relaxed look,” Eliza Walter, founder of Lylie Jewellery, tells Vogue. “In warmer months or during summer holidays, many opt to wear just their wedding band and eternity ring together—a combination that feels both effortless and meaningful.”

    Of course, eternity rings are often deeply meaningful, traditionally bought to mark special milestones (there is speculation that Kate’s Étincelle de Cartier wedding band was gifted to her by William to mark their 13th wedding anniversary last year). “Eternity rings are a timeless symbol, a circle of precious metal traditionally set with stones all the way around, representing an unbroken bond and infinite commitment,” jeweler Rachel Boston explains. “The continuous line of diamonds or gemstones is a reminder that, like the ring itself, true love has no beginning or end.”

    If Kate’s choice of jewelry at Wimbledon is anything to go by, it seems that the ring stacking trend isn’t going anywhere. All the better if each piece is imbued with sentimental value—a collection that’s been inherited or built up over the years.

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  • RAMP 201 Data Shows Advancements in Recurrent Low-Grade Serous Ovarian Cancer

    RAMP 201 Data Shows Advancements in Recurrent Low-Grade Serous Ovarian Cancer

    Ovarian cancer: ©Dr_Microbe – stock.adobe.com

    Primary results from the phase 2 RAMP 201 trial (NCT04625270) evaluating the combination therapy of avutometinib and defactinib (Avmapki Fakzynja co-pack) for patients with KRAS-mutated recurrent low-grade serous ovarian cancer (LGSOC) show that this dual-pathway inhibition strategy offers a promising new avenue for a patient population with historically limited effective treatment options.1

    The results, published in the Journal of Clinical Oncology, demonstrated robust objective response rates (ORR) with the avutometinib and defactinib combination, even in patients who had undergone multiple prior lines of therapy. The ORR was 31% (n = 34/109), with a notably higher response rate of 44% (n = 22/57) observed in patients harboring KRAS mutations. In the KRAS wild-type cohort, the ORR stood at 17% (n = 9/52). A compelling aspect of the data was the significant proportion of patients (82%) experiencing some reduction in target lesions, irrespective of their KRAS mutation status, underscoring the broad potential of this therapeutic approach.

    These findings supported the FDA’s accelerated approval of the combination earlier this year, on May 8, 2025.2

    Furthermore, the trial’s efficacy data highlighted durable responses and meaningful progression-free survival (PFS).1 The median PFS for the overall study population was 12.9 months. For KRAS-mutant patients, this extended to an impressive 31.0 months, while KRAS wild-type patients achieved a median PFS of 12.8 months. The median duration of response (DOR) for all patients was 31.1 months. This extended DOR, particularly in a recurrent setting, signals a substantial clinical benefit.

    The safety profile of the avutometinib and defactinib combination was generally well tolerated in the RAMP 201 trial, with a 10% discontinuation rate due to adverse events (AEs). Common AEs observed included nausea, diarrhea, and increased creatine phosphokinase levels, consistent with the known mechanisms of action of these inhibitors. Important safety information for the combination includes warnings and precautions regarding potential ocular toxicities, serious skin toxicities, hepatotoxicity, rhabdomyolysis, and embryo-fetal toxicity. Clinicians should be aware of these potential risks and monitor patients accordingly.

    These positive outcomes are crucial given the challenges associated with LGSOC, a rare and highly recurrent form of ovarian cancer that affects an estimated 6000 to 8000 patients in the US and 80,000 globally. Distinct from high-grade serous ovarian cancer, LGSOC often presents with a more indolent course but is typically resistant to conventional chemotherapy, leading to high recurrence rates and a persistent need for novel therapies. Approximately 70% of LGSOC cases exhibit mutations within the RAS pathway, with about 30% specifically presenting with a KRAS mutation.

    The therapeutic rationale behind the avutometinib and defactinib combination targets key oncogenic pathways. Avutometinib functions as a MEK kinase inhibitor while simultaneously blocking the compensatory reactivation of MEK by RAF. Defactinib, on the other hand, inhibits FAK, a protein recognized for its role in mediating drug resistance. This synergistic inhibition aims to overcome resistance mechanisms often observed in RAS/MAPK pathway-driven cancers, leading to the observed clinical responses.

    Beyond the FDA accelerated approval for KRAS-mutated recurrent LGSOC, the clinical implications of the RAMP 201 results are further reflected in the National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines, where the combination is currently a Category 2A recommendation for this specific patient subset. Verastem Oncology has indicated plans to submit the RAMP 201 publication to the NCCN to support the potential inclusion of the KRAS wild-type population in these guidelines, which could expand access to this treatment.

    Building on the success of RAMP 201, Verastem Oncology is continuing to advance its research in LGSOC with the ongoing international phase 3 RAMP 301 trial (NCT06072781).3 This pivotal trial is designed to further evaluate the avutometinib and defactinib combination in a broader population of patients with recurrent LGSOC, encompassing both KRAS-mutated and KRAS wild-type disease, aiming to solidify its role as a standard of care.

    REFERENCES:
    1. Verastem Oncology announces publication of the primary results from the phase 2 RAMP 201 trial of avutometinib in combination with defactinib in patients with recurrent low-grade serous ovarian cancer in the Journal of Clinical Oncology. News release. Verastem Oncology. July 11, 2025. Accessed July 14, 2025. https://tinyurl.com/4w5tndx6
    2. FDA grants accelerated approval to the combination of avutometinib and defactinib for KRAS-mutated recurrent low-grade serous ovarian cancer. US FDA. News release. May 8, 2025. Accessed July 14, 2025. https://bit.ly/430Wjzz
    3. A study of avutometinib (VS-6766) v. avutometinib (VS-6766) + defactinib in recurrent low-grade serous ovarian cancer with and without a KRAS mutation (RAMP 201). ClincalTrials.gov. Updated January 29, 2025. Accessed July 14, 2025. https://clinicaltrials.gov/study/NCT04625270

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  • ‘People always say, “I love you, Gramps”’: why these seniors love video games | Well actually

    ‘People always say, “I love you, Gramps”’: why these seniors love video games | Well actually

    Some research suggests older adults may experience benefits from gaming, though effects depend on the type of game. Composite: Guardian/Getty Images

    Michelle Statham’s preferred game is Call of Duty. It’s fast and frenetic, involving military and espionage campaigns inspired by real history. She typically spends six hours a day livestreaming to Twitch, chatting to her more than 110,000 followers from her home in Washington state. She boasts about how she’ll beat opponents, and says “bless your heart” while hurtling over rooftops to avoid clusterstrikes of enemy fire. When she’s hit, she “respawns” – or comes back to life at a checkpoint – and jumps right back into the fray.

    The military shooter game has a predominantly young male user base, but Statham’s Twitch handle is TacticalGramma – a nod to the 60-year-old’s two grandkids. Her lifelong gaming hobby has become an income stream (she prefers to keep her earnings private, but says she has raised “thousands” for charity), as well as a way to have fun, stay sharp and connect socially.

    “A lot of people are surprised that someone my age is playing video games,” Statham admits. She finds the gameplay exhilarating. “When I get really good long sniper shots in, or down someone out of a helicopter, that’s pretty fun,” she says.

    Statham juggles in-game multitasking with live-chatting to her multigenerational streaming audience. Younger followers have taught her slang, like the gen Z shibboleth “skibidi”. “I’ve learned some things I don’t want to learn,” she says, laughing. When she tires, she plays privately off-stream to unwind. She also exercises daily, going to the gym with her daughter as part of the 75 Hard fitness challenge, to ensure gaming doesn’t displace physical activity.

    Statham is one of the 57 million Americans over 50 who game, a cohort that represents 28% of roughly 205 million total US gamers, shows recent data from the Entertainment Software Association. According to the ESA, nearly half of Americans in their 60s and 70s play some form of PC, mobile or console video game every week, as do 36% of people in their 80s. And as more gamers like Statham enter their golden years, older adults are becoming more visible in the gamer mainstream – sometimes to the confusion of their peers on multiplayer platforms.

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    “Age is like having a sign around your neck saying: ‘I’m old and I can’t do this,’” says Will, 72, a Missouri-based retired navy veteran who prefers to keep his last name private, but streams his favorite games, like hunting simulator theHunter: Call of the Wild and air combat game Metalstorm, to 1.4 million YouTube subscribers under the username GrndpaGaming.

    “That’s not the case with me and other up-and-coming older gamers that are out there,” says Will. “Someone my age can keep up with technology.”

    Some research suggests older adults may experience benefits from gaming, though effects depend on the type of game.

    There are games created to help boost memory and attention, such as those by the science-based company BrainHQ, which developed a game called Double Decision often used by researchers to test and improve people’s visual processing, and the Lumosity mobile gaming app, which features a popular brain training game called Train of Thought.

    ‘Nearly half of Americans in their 60s and 70s play some form of video game every week.’ Photograph: Michelle Statham

    More generally, puzzle games like Tetris and Monument Valley, which require players to remember patterns, sequences and spatial layouts, have been shown to help players of any age improve visual memory and cognitive processing. Fitness games that incorporate physical movement, like Ring Fit Adventure or Hot Squat, may improve balance better than conventional rehabilitation in MS patients.

    But what about first-person shooter games?

    Dr Gregory West, an associate professor in psychology at the University of Montreal, ran a study on participants of all ages in 2018. He found those tasked with hours of playing first-person shooters like Call of Duty experienced a reduction in grey matter in the hippocampal region of the brain. Those who played games involving the exploration of 3D open worlds, like Super Mario 64 or The Legend of Zelda: Breath of the Wild, showed improvement in the same area.

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    “A reduced volume in the hippocampus is associated with a risk for neuropsychiatric illness across the lifespan,” explains West. “During ageing, older adults with less activity and grey matter in the hippocampus are at increased risk of developing Alzheimer’s disease.”

    But that doesn’t mean older gamers should necessarily stop playing first-person shooters. “It really is a mixed bag when we consider the impact of these games on the ageing brain,” admits West.

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    For one, West’s study didn’t focus on how gaming affects older brains specifically, and he notes that older folks who are successful competitive gamers likely have “pretty good cognitive abilities” to begin with.

    Then, there are also social benefits that come with gaming on multiplayer platforms, where first-person shooters are popular. “Older adults, through playing video games online with other people and communicating through microphones, are receiving real social stimulation, and I think that positive benefit cannot be ignored even in the face of a possible risk for Alzheimer’s disease,” he says.

    “As long as you keep your brain active and functioning, you’re not going to sit there and just deteriorate away,” says Will.

    Even amid percussive gunfire, the chats of combat games can be genuinely sweet. “People always say: ‘I love you, Gramps. Keep on doing what you’re doing’… things like that, that really tug at your heart,” says Will.

    Gaming can help people with a variety of ailments, says Dr Kris Alexander, a leading authority in video game design and associate professor of media production at Toronto Metropolitan University who helped launch GameRx, an online resource hub for information about wellness and gaming. One 2017 study found that “if you play Tetris within 48 hours of a traumatic experience, you can reduce PTSD”, he tells me. “There are studies that show that if you place burn victims in virtual reality in spaces where they’re surrounded by cold elements, you can reduce their pain.”

    Alexander believes gaming can be good for seniors; over a video call, he shows me the custom arcade cabinet he’s built to house every game he’s ever owned. “For my retirement,” he tells me. “Absolutely, when I get older, I’m going to be playing video games.”

    However, common conditions like joint pain and vision decline can hinder senior gamers. As that demographic grows, so may demand for accessibility tools. And because the senior player base is relatively small, Alexander acknowledges that the high-budget gaming companies behind blockbuster titles like Call of Duty and Skyrim are unlikely to account for such needs.

    In 2010, Will required surgery implanting a steel plate in his skull; since then, if he sits in a chair “for more than 20 or 30 minutes, everything from the shoulders down to the fingertips goes numb”, he says. Now, he uses a hand-shaped gaming keypad called the Azeron Cyborg II, which allows users with limited hand mobility or strength to position PC keys so they’re easy and comfortable to reach. Other adaptive controllers, including voice-control technology, pedals designed for control by foot or mouth, and 3D printable controller modifications for consoles like the Xbox and Playstation, are all making gaming increasingly accessible across playing formats.

    Will hopes that other seniors who see him stream will be inspired to get into gaming. “If I can do it at my age with this handicap, you can, too,” he says. After all, you’re never too old to respawn.

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  • Narcotics worth over Rs1 billion siezed in Arabian Sea operation

    Narcotics worth over Rs1 billion siezed in Arabian Sea operation

    KARACHI (Web Desk) – In a major inter-agency operation, the Pakistan Navy (PN), Pakistan Maritime Security Agency (PMSA), Joint Maritime Information Coordination Centre (JMICC), and the Narcotics Control Wing of the Excise, Taxation & Narcotics Control Department (Sindh) have successfully conducted a joint maritime and intelligence-based operation in the Arabian Sea.

    The coordinated action involved surveillance missions and real-time maritime patrols, which led to the interception of a stateless vessel operating illegally in the region.

    A thorough search of the vessel uncovered over 500 kilograms of narcotics, including hashish and crystal ice (methamphetamine), prepared for illegal distribution.

    Illicit liquor confiscation

    In a separate intelligence-based operation, the agencies also seized a large quantity of illicit liquor concealed onboard another vessel. The confiscated contraband was intended for unlawful circulation.

    The operations were made possible through effective intelligence sharing, seamless coordination, and swift execution by the participating forces.

    Contraband worth over Rs1 billion

    Authorities estimate the total street value of the seized drugs and liquor at more than Rs1 billion.

    The recovered items have been formally handed over to the Excise, Taxation & Narcotics Control Department (Sindh) for further legal proceedings.

    The success of these operations demonstrates the enhanced operational synergy between Pakistan’s maritime and law enforcement agencies. It also reaffirms their joint commitment to combating illicit trade, safeguarding national maritime interests, and contributing to regional stability.


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