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  • Lorna Raver, Actress in ‘Drag Me to Hell,’ Dies at 81 – The Hollywood Reporter

    Lorna Raver, Actress in ‘Drag Me to Hell,’ Dies at 81 – The Hollywood Reporter

    1. Lorna Raver, Actress in ‘Drag Me to Hell,’ Dies at 81  The Hollywood Reporter
    2. ‘Young and the Restless’ Actress Passes Away & Tributes Pour In  EntertainmentNow
    3. Lorna Raver, actor from Drag Me to Hell, dies at 81  The Guardian
    4. Actress Lorna Raver Dead At 81  iHeart
    5. Lorna Raver, “Drag Me to Hell” and “Young and the Restless” actress, dies at 81  Yahoo News UK

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  • Alpelisib Combo Does Not Extend PFS in High-Grade Serous Ovarian Cancer

    Alpelisib Combo Does Not Extend PFS in High-Grade Serous Ovarian Cancer

    “Additional treatment strategies are being explored in platinum-resistant HGSOC, and additional research into novel targeted therapies is warranted to address the unmet needs in this patient population,” according to the study authors.

    Combining alpelisib (Piqray) with olaparib (Lynparza) did not improve progression-free survival (PFS) vs chemotherapy among patients with platinum-resistant or platinum-refractory high-grade serous ovarian cancer (HGSOC) without a BRCA mutation, according to findings from the phase 3 EPIK-O/ENGOT-ov61 trial (NCT04729387) published in Journal of Clinical Oncology.1

    Based on blinded independent review committee (BIRC) assessment, the median PFS was 3.6 months (95% CI, 3.4-4.3) with the alpelisib combination vs 3.9 months (95% CI, 3.7-5.4) with chemotherapy (HR, 1.14; 95% CI, 0.88-1.48; P = .84). Additionally, the median PFS was 3.7 months in both arms based on investigator evaluation (HR, 1.02; 95% CI, 0.79-1.30; P = .54).

    Data revealed an objective response rate (ORR) of 15.6% (95% CI, 10.6%-21.7%) in the experimental arm vs 13.5% (95% CI, 8.8%-19.4%) in the comparator arm. The clinical benefit rate (CBR) was 21.1% vs 19.1% in each respective arm, and the median duration of response (DOR) was 7.4 months (95% CI, 5.0-12.9) vs 5.6 months (95% CI, 3.8-not evaluable [NE]).

    Due to the trial being unable to demonstrate statistical significance for PFS, investigators did not formally evaluate overall survival (OS). The median OS was 10.0 months with alpelisib/olaparib vs 10.6 months with chemotherapy (HR, 1.22; 95% CI, 0.87-1.71), and OS events occurred in 41.7% vs 35.4% of each arm.

    “[T]his protocol-specified final PFS analysis of EPIK-O/ENGOT-ov61 did not meet its primary efficacy end point of PFS improvement with alpelisib [plus] olaparib vs treatment of physician’s choice [TPC] in patients with platinum-resistant [or] platinum-refractory HGSOC with no BRCA mutation,” lead study author Panagiotis A. Konstantinopoulos, MD, PhD, director of the Mellen and Eisenson Family Center for BRCA and Related Genes and director of Translational Research in the Division of Gynecologic Oncology at Dana-Farber Cancer Institute, wrote with coauthors in the publication.1 “Additional treatment strategies are being explored in platinum-resistant HGSOC, and additional research into novel targeted therapies is warranted to address the unmet needs in this patient population.”

    In the multicenter, open-label EPIK-O trial, 358 patients were randomly assigned to receive alpelisib plus olaparib (n = 180) or TPC (n = 178). Patients in the experimental arm received alpelisib at 200 mg orally once daily plus olaparib at 200 mg once daily in each 28-day cycle. Treatment in the TPC arm consisted of paclitaxel at 80 mg/m2 intravenously once weekly or pegylated liposomal doxorubicin (PLD) at 40 to 50 mg/m2 once every 28 days.

    The trial’s primary end point was PFS per BIRC using RECIST v1.1 criteria. Secondary end points included OS, DOR, CBR, and safety.

    Patients 18 to 100 years old with histologically confirmed high-grade serous high-grade endometrioid ovarian cancer, fallopian tube cancer, or primary peritoneal cancer were eligible for enrollment on the trial.2 Additional eligibility criteria included having no germline BRCA1/2 mutations, an ECOG performance status of 0 or 1, platinum-resistant or platinum-refractory disease, and adequate bone marrow and organ function.

    The median age was 61 years (range, 32-81) in the alpelisib/olaparib arm and 61 years (range, 37-84) in the TPC arm. Most patients in each respective arm had an ECOG performance status of 0 (63.9% vs 61.2%), no ascites (78.3% vs 83.1%), serous adenocarcinoma histology (92.2% vs 97.2%), intra-abdominal disease (85.0% vs 87.1%), 1 metastatic site (40.6% vs 44.4%), and measurable disease (90.6% vs 86.5%). Additionally, a majority in each arm had no prior treatment with PARP inhibitors (66.7% vs 62.9%), although most were previously treated with bevacizumab (Avastin; 80.6% vs 78.7%).

    Adverse effects (AEs) of any grade affected 98.9% of the alpelisib arm and 97.6% of the chemotherapy arm, with serious AEs occurring in 51.1% and 30.5%, respectively. The most common types of any-grade AEs in each arm included nausea (61.7% vs 31.7%), hyperglycemia (52.2% vs 3.7%), vomiting (41.1% vs 20.7%), and diarrhea (41.1% vs 18.3%). Grade 3 or higher AEs in each arm included hyperglycemia (18.9% vs 0%), vomiting (10.0% vs 1.2%), nausea (9.4% vs 1.2%), and anemia (7.2% vs 4.9%).

    Dose reductions for alpelisib, olaparib, and TPC, occurred in 36.7%, 45.6%, and 20.1% of patients, respectively; dose interruptions were necessary in 66.7%, 52.8%, and 20.1%. Additionally, 14.4% and 4.3% of patients in the alpelisib and TPC arms experienced on-treatment deaths. One patient in the alpelisib/olaparib arm had a treatment-related fatal serious AE.

    References

    1. Konstantinopoulos PA, Kim JW, Freyer G, et al. Alpelisib plus olaparib versus chemotherapy in platinum-resistant or platinum-refractory high-grade serous ovarian cancer without BRCA mutation. J Clin Oncol. Published online July 23, 2025. doi:10.1200/JCO-25-00225
    2. Alpelisib plus olaparib in platinum-resistant/​refractory, high-grade serous ovarian cancer, with no germline BRCA mutation detected. ClinicalTrials.gov. Updated February 12, 2025. Accessed August 11, 2025. https://tinyurl.com/2ka8xx4v

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  • How ‘KPop Demon Hunters’ became the surprise hit of the summer – San Francisco Chronicle

    1. How ‘KPop Demon Hunters’ became the surprise hit of the summer  San Francisco Chronicle
    2. HUNTR/X’s ‘Golden’ From ‘KPop Demon Hunters’ Hits No. 1 on Billboard Hot 100  billboard.com
    3. ‘K-Pop Demon Hunters’ singalong tickets sell out for August screenings  The Express Tribune
    4. A Special KPop Demon Hunters Sing-Along Event Is Headed to a Theater Near You  Netflix
    5. ‘KPop Demon Hunters’ Stars on Making Goofy Girls ‘Feel Seen’ and Sequel Hopes: ‘Rescue Jinu!’  Variety

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  • Exposure to air pollutant sulfur dioxide tied to greater ALS risk

    Exposure to air pollutant sulfur dioxide tied to greater ALS risk

    Long-term exposure to sulfur dioxide (SO2), a gaseous air pollutant generated by the burning of fossil fuels, significantly increases the risk of developing amyotrophic lateral sclerosis (ALS), according to a study in Canada.

    Exposure to other forms of air pollution, including nitrogen dioxide (NO2), ground-level ozone (O3), and PM2.5 , was not associated with ALS, the data suggested. PM2.5 is fine particulate matter with a diameter of 2.5 micrometers or less.

    “Our findings support the association between long-term exposure to air pollutants, particularly [sulfur dioxide], and the development of ALS, supporting the need for improved air pollution control measures,” researchers wrote.

    Their study, “Associations between long-term air pollution exposure and the development of amyotrophic lateral sclerosis: A matched case-control study,” was published in Environmental Research.

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    Odds of ALS higher with increasing sulfur dioxide exposure

    Both genetic susceptibility and environmental exposures are thought to play a role in the development of ALS, a rare neurological disorder marked by the progressive loss of voluntary muscle function.

    Prior research has supported a relationship between exposure to air pollution and the development of other neurological conditions, such as Parkinson’s and Alzheimer’s diseases. However, there have been few studies examining a potential connection between air pollution and ALS risk.

    To learn more, a team of researchers in Canada analyzed data from 304 people with ALS and 1,207 matched healthy individuals, who served as controls. Participants were 64 years old on average, a little more than half were men (52%), and 39% lived in rural areas.

    “It was hypothesized that long-term exposures to environmental factors in the surrounding residential area of individuals played a role in the development of ALS,” the researchers wrote.

    The team used available information about participants’ residences and pollution levels in various locations. Air pollutants investigated included NO2 and SO2, which are both produced by the burning of fossil fuels, as well as O3, a byproduct of NO2. PM2.5 — the sources of which include smoke, soot, dust, and pollen PM2.5  — was also assessed.

    This is the first study to highlight that higher levels of ambient SO2 in residential areas relate to an increased risk of ALS.

    The analysis revealed that the median annual levels of SO2 were significantly higher around the residences of ALS individuals compared with those of controls, but that was not the case for all other air pollutants.

    After adjustments for other factors that could influence the risk of ALS, the odds of an ALS diagnosis significantly increased by 1.23-fold for a 0.14 part-per-billion increase in SO2 exposure. This relationship was significant for SO2 exposures from five to 10 years before the onset of ALS. No associations were found between ALS and exposure to NO3, O3, or PM2.5.

    Further analysis suggested the odds of ALS were higher with increasing exposure to SO2, with the highest exposure being significantly different from the lowest. Still, the relationship was not linear, meaning, for example, that a twofold increase in SO2 exposure did not double the ALS risk.

    “This is the first study to highlight that higher levels of ambient SO2 in residential areas relate to an increased risk of ALS,” the researchers wrote. “More research is thus needed to determine if SO2 exposure is a key causal element for the development of ALS or merely accelerating an already self-perpetuating neurodegenerative process.”

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  • Disney Reorganizes Marketing Under Asad Ayaz, Shannon Ryan

    Disney Reorganizes Marketing Under Asad Ayaz, Shannon Ryan

    Disney Entertainment is restructuring its marketing division, with executives Asad Ayaz and Shannon Ryan each taking on new roles.

    Ayaz, chief brand officer for The Walt Disney Co., is also adding the title of president of Disney Entertainment Marketing, reporting to Disney Entertainment co-chairs Alan Bergman and Dana Walden. He’ll oversee marketing efforts for Disney’s studios and TV and streaming outlets while also leading brand strategy under CEO Bob Iger, including the in-house agencies for Disney Experiences and Disney Entertainment.

    Ryan, currently the head of TV marketing, will add direct-to-consumer to her purview as president, DTC and Disney Entertainment Television Marketing. The marketing teams for Disney+, led by Samantha Rosenberg, and Hulu, led by Barrie Gruner, will report to her as part of a unified team following the announcement that Hulu will be fully integrated into Disney+ next year.

    Ryan will report to Ayaz while still remaining on Walden’s leadership team.

    “These changes reflect our confidence in the exceptional talent across our marketing organization, and we’re excited for what’s ahead,” Bergman and Walden wrote in a memo to staff Wednesday (read it in full, below). “We are grateful for your continued creativity, passion, and partnership as we shape the future of Disney Entertainment together.”

    Ayaz is a 20-year Disney veteran and has led marketing efforts for some of the company’s biggest film and TV releases of recent years, among them the live-action Lilo & Stitch, Moana 2, Marvel’s Avengers and Black Panther films, Andor and The Beatles: Get Back. Ryan joined Disney when it bought Fox’s entertainment assets, having previously served as chief marketing officer for Fox Television Group. She has spearheaded campaigns for Abbott Elementary, breakout hit High Potential, the Oscars and Jimmy Kimmel Live!, among many others.

    Bergman and Walden’s memo is below.

    Team,

    Disney Entertainment is home to an iconic and acclaimed collection of storytelling brands, and our marketing teams play a vital role in bringing the magic of Disney storytelling to audiences around the world. As we continue to scale our business globally, we’d like to share an update about the future of our marketing structure, particularly focused on supporting the full integration of Hulu into Disney+ that Bob announced during earnings last week.
     
    To create a more unified strategy across streaming, film, and television, we’re realigning our marketing organization to create one best-in-class Disney Entertainment Marketing team under the leadership of Asad Ayaz, who will now report to the both of us. Asad is a strategic leader with sharp creative instincts who has been instrumental in driving high-impact campaigns at both the company and the Studio. As Chief Brand Officer, TWDC, and President, Disney Entertainment Marketing, he will now oversee marketing for our studios, television, and streaming, while continuing to drive brand strategy for the company under Bob Iger, including leading our in-house creative agencies for Disney Experiences and Disney Entertainment. This dual role will further connect all the company’s consumer touchpoints and align our marketing approach.
     
    Shannon Ryan will add DTC to her portfolio and oversee a newly integrated team across Disney+ and Hulu, while continuing to lead marketing for television content. Shannon is a dynamic marketing leader with a proven track record of crafting innovative campaigns that resonate with audiences and create breakout hits. As President, DTC and Disney Entertainment Television Marketing, she will now report to Asad, while remaining on Dana’s leadership team. Barrie Gruner and Samantha Rosenberg will both report to Shannon moving forward.
     
    Operating as one cohesive DTC marketing team will enable us to speak to consumers with greater efficiency and impact, and this new structure will also create a deeper connection and collaboration across all of our marketing efforts. These changes reflect our confidence in the exceptional talent across our marketing organization, and we’re excited for what’s ahead. We are grateful for your continued creativity, passion, and partnership as we shape the future of Disney Entertainment together.
     
    Alan & Dana

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  • New draft of global plastic pollution treaty wouldn’t limit plastic production

    New draft of global plastic pollution treaty wouldn’t limit plastic production

    GENEVA (AP) — Negotiators working on a treaty to address global plastic pollution discussed a new draft of the text Wednesday that wouldn’t limit plastic production or address chemicals used in plastic products.

    The biggest issue of the talks has been whether the treaty should impose caps on producing new plastic or focus instead on things like better design, recycling and reuse. About 100 countries want to limit production as well as tackle cleanup and recycling. Many have said it’s essential to address toxic chemicals.

    Powerful oil and gas-producing nations and the plastics industry oppose production limits. They want a treaty focused on better waste management and reuse.

    Countries with very divergent views expressed disappointment with the draft. It could change significantly and a new version is expected Thursday, the last scheduled day of the negotiations.

    When they convened Wednesday night, Colombia’s delegation said that the text was entirely unacceptable, because it was unbalanced, and lacked the ambition and global obligations needed to end plastic pollution. The delegation said that it wouldn’t accept the wording as the basis for negotiations.

    The head of Panama’s delegation to the talks, Juan Carlos Monterrey Gómez, stood up and cheered. Many delegations made statements to agree, including Mexico, Chile, Ghana, Canada, Norway, the United Kingdom, the European Union and the group of small island developing states.

    “Let me be clear — this is not acceptable for future generations,” said Erin Silsbe, representing Canada.

    Oil- and gas-producing nations raised other concerns, with Saudi Arabia, Kuwait, Qatar and others saying that the draft doesn’t have the scope they want to set the parameters of the treaty or precise definitions.

    The United States said that six articles cross red lines, but didn’t say how.

    India’s delegation, on the other hand, said that the draft is a “good enough starting point.”

    The draft contains one mention of plastic production in the preamble, reaffirming the importance of promoting sustainable production and consumption of plastics. It doesn’t contain an article on production from a previous draft. There is no mention of chemicals.

    AP AUDIO: New draft of global plastic pollution treaty would not limit plastic production

    AP correspondent Charles de Ledesma reports the global plastic pollution treaty is going down to the wire.

    The new provisions seek to reduce the number of problematic plastic products that often enter the environment and are difficult to recycle and promote the redesign of plastic products, so that they can be recycled and reused. Parties to the treaty would improve their waste management.

    Luis Vayas Valdivieso, the chair of the negotiating committee, wrote the draft based on the views expressed by nations over the course of the negotiations. He told them that he did it to move them closer to a legally-binding instrument, and they can shape and improve it, as well as add and delete wording.

    With little time left, he said, it’s time to build bridges, not dig in over red lines.

    ___

    The Associated Press’ climate and environmental coverage receives financial support from multiple private foundations. AP is solely responsible for all content. Find AP’s standards for working with philanthropies, a list of supporters and funded coverage areas at AP.org.


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  • Resident Evil: Survival Unit Cinematic Trailer Samples QUEEN BEE Theme Song – Crunchyroll

    Resident Evil: Survival Unit Cinematic Trailer Samples QUEEN BEE Theme Song – Crunchyroll

    1. Resident Evil: Survival Unit Cinematic Trailer Samples QUEEN BEE Theme Song  Crunchyroll
    2. Mobile-only Resident Evil Survival Unit gets new cinematic trailer with music by Japanese rock band Queen Bee  Eurogamer
    3. Resident Evil Survival Unit Confirms Some Familiar Boss Characters  IGN India
    4. ‘Resident Evil Survival Unit’ Has Garnered Over One Million Pre-Registrations  Bloody Disgusting
    5. Resident Evil Survival Unit Set 1 Million Pre-Registration Milestone  Yardbarker

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  • Ireland squad named for Women’s T20 Euro qualifier

    Ireland squad named for Women’s T20 Euro qualifier

    Ireland have named their 14-strong squad for the Women’s T20 World Cup European Qualifier in Rotterdam, which runs from 20-27 August.

    Hosts Netherlands, Italy, and Germany will provide the opposition with Ireland playing each nation twice in a round robin format. The top two will progress to the Global Qualifier in Nepal which will contain 10 teams.

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    Gaby Lewis, who was nominated for the ICC Women’s player of the Month for July, will captain the side with Orla Prendergast named vice captain, having recently risen to sixth position in the T20 all-rounders list.

    Ireland swept a three-game series against Zimbabwe in July before a 2-1 series win against Pakistan with the only change from the latter squad seeing Alana Dalzell replacing Louise Little.

    The squad contains plenty of experience as Lewis and Laura Delany have already reached the 100 cap mark, while Prendergast, Rebecca Stockell, Leah Paul, Cara Murray and Arlene Kelly have surpassed 50. Amy Hunter will join this club should she start the opening game against Germany on 20 August.

    Two members of the squad have the chance to become the first Irish woman to achieve the double of 1500 runs and 50 wickets in the T20 format with Delany 21 runs away and Predergast 54 short.

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    “Qualifier campaigns are notoriously tough, with fixtures coming thick and fast,” said Ireland selector, Ciara O’Brien.

    “The squad we have chosen, while relatively young in age, have almost 650 caps collectively in the T20I format, so have plenty of experience to draw upon. This experience, as well as a recent hard-fought series win over Pakistan, have the players in a good place and eager to take the first steps towards World Cup qualification.”

    T20 World Cup European Qualifier squad

    Gaby Lewis (captain), Ava Canning, Christina Coulter Reilly, Alana Dalzell, Laura Delany, Amy Hunter, Arlene Kelly, Jane Maguire, Lara McBride, Cara Murray, Leah Paul, Orla Prendergast, Freya Sargent, Rebecca Stokell

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    Ireland’s fixtures

    20 August: Ireland v Germany (14.45 BST)

    21 August: Ireland v Netherlands (10:00 BST)

    23 August: Ireland v Italy (10:00 BST)

    24 August: Ireland v Germany (10:00 BST)

    26 August: Ireland v Netherlands (14.45 BST)

    27 August: Ireland v Italy (14.45 BST)

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  • Discovery Confirms Early Species of Hominins Co-Existed in Ethiopia

    Discovery Confirms Early Species of Hominins Co-Existed in Ethiopia



    Photo by Russell Cothren

    Lucas Delezene

    While we know much of the story of how humans evolved, the puzzle is still missing critical pieces. For example, fossil evidence for human evolution between 2 and 3 million years ago is patchy. It’s frustrating because we know that the branch of the hominin family tree that includes humans, or Homo sapiens, appears in the fossil record for the first time in this period.

    Today, Homo sapiens (which anthropologists shorten to Homo), is the only hominin species alive. But in the past, Homo wasn’t alone. We coexisted and competed with other branches of the human family tree. Research supported by the National Science Foundation and the Leakey Foundation and published in Nature now fills in a piece of the ongoing evolutionary puzzle, placing two early species of hominin side-by-side.

    A team working in the Afar Region of Ethiopia, at the site of Ledi-Geraru, reports hominin fossils that date between 2.6 and 3.0 million years old. Lucas Delezene, an associate professor of anthropology at the University of Arkansas, was second author on a paper that incorporated the work of more than 20 researchers from North America, Africa and Europe.

    The team found fossils of Homo that confirm the earliest evidence for the human lineage at 2.8 million years ago as well as evidence of Homo at 2.6 million years ago, solidifying the antiquity of Homo. Unexpectedly, the team also found evidence that Homo overlapped at the site with a different type of hominin, Australopithecus, at 2.6 million years ago.

    This was a surprise because Australopithecus was thought to be extinct in the area by about 3 million years ago. The famous Australopithecus fossil known as Lucy was found at a nearby site, but her species disappeared from the fossil record at 3 million years ago.

    “People often think evolution is a linear progression,” explains Delezene, “like the March of Progress, but in reality humans are only one species that make up a twig of a bigger family tree — it’s quite bushy and what we found is another twig that was previously unknown. The idea that Homo appears and immediately spreads around the planet and replaces all other hominin species is not accurate. Homo lived side-by-side with many other hominin species throughout Africa. What’s neat is that Homo overlaps with different hominin species in different places.”

    For example, from southern Ethiopia to southern Africa, the earliest species of Homo overlapped with a hominin known as Paranthropus, which is well known for its massive teeth and chewing muscles and a diet reliant on grass in some parts of its range. However, in the Afar Region of Ethiopia, no Paranthropus fossils have ever been found.

    Instead, the team working at Ledi-Geraru found that Homo overlap with a different type of hominin, Australopithecus. How all of these hominin species divided up resources is the question of ongoing research. Did Homo nod to the other hominin species on their way to hunting and gathering in the morning, or did the various species consume similar resources? Did Homo eat the same things in Ethiopia where it coexisted with Australopithecus as it did in the south where it coexisted with Paranthropus, or was its diet flexible?

    We know that Homo eventually becomes a culturally reliant tool user and occasionally consumed meat. But the oldest Homo fossils at Ledi-Geraru predate any evidence of tool manufacture or meat consumption. Did Homo evolve those traits to avoid competing with other hominin species? Competition among these various hominin species likely set the stage for the evolution of the traits that ultimately made humans a globally widespread and successful species.

    The fossils published in the Nature paper are all teeth. Teeth are often the best-preserved fossils because their enamel coating provides better protection from the ravages of time and the elements.

    Delezene, a hominin dental expert, says, “When we get down to the picky details, the teeth of Homo and Australopithecus look different. The differences are subtle, but once you see them, you can’t unsee them. They’re very consistent.”

    While the new fossils fill in a piece of the puzzle, there is still a long way to go before we have a complete picture of human evolution. While there is evidence for the teeth of early Homo and the new Australopithecus, the team doesn’t know what their heads or the rest of their bodies looked like. The multi-national collaboration, done in partnership with the local community of Afar people, will continue its work looking for more fossils, ideally with continued funding.

    About the University of Arkansas: As Arkansas’ flagship institution, the U of A provides an internationally competitive education in more than 200 academic programs. Founded in 1871, the U of A contributes more than $3 billion to Arkansas’ economy  through the teaching of new knowledge and skills, entrepreneurship and job development, discovery through research and creative activity while also providing training for professional disciplines. The Carnegie Foundation classifies the U of A among the few U.S. colleges and universities with the highest level of research activity. U.S. News & World Report ranks the U of A among the top public universities in the nation. See how the U of A works to build a better world at Arkansas Research and Economic Development News.

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