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  • Swiatek eases past Bencic into first career Wimbledon final

    Swiatek eases past Bencic into first career Wimbledon final

    Iga Swiatek’s career-best grass-court season has reached new heights: a trip to the Wimbledon final for the first time.

    Wimbledon: Scores Order of play | Draws

    No. 8 seed Swiatek of Poland breezed past 35th-ranked Belinda Bencic of Switzerland 6-2, 6-0 in their final-four meeting on Centre Court on Thursday. In a clash between two first-time Wimbledon semifinalists, Swiatek needed just 1 hour and 12 minutes to triumph.

    Former World No. 1 Swiatek has not won a title since 2024 Roland Garros over a year ago, but she is now a victory away from returning to the winner’s circle here on the grass of Wimbledon — her least successful Grand Slam before this year.

    Suddenly, five-time Grand Slam champion Swiatek is posting outstanding results on turf this season. She made her first grass-court final at Bad Homburg two weeks ago, and is now into her second final on the surface — at the grass-court major, no less.

    Despite her previous misgivings on grass at tour level, Swiatek has to feel confident in a Grand Slam final on any surface. She is a perfect 5-0 in Grand Slam singles finals — leading to four titles at Roland Garros (2020, 2022-24) and one at the 2022 US Open.

    Swiatek will now face No. 13 seed Amanda Anisimova of the United States for the Wimbledon ladies’ singles title on Saturday. Stunningly, they have never faced each other on the pro tour. They met once as juniors in 2016, and Swiatek won.

    More to come…

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  • Measles Cases At A 33 Year High, According To CDC Report

    Measles Cases At A 33 Year High, According To CDC Report

    More cases of measles have occurred in the United States in 2025 than in any year since 1991, according to a report released on Wednesday by the Centers for Disease Control and Prevention. Over half of the 1,288 confirmed cases have occurred in Texas, although cases have been reported in 38 states. Roughly 13% of the people diagnosed with measles this year have been hospitalized and three have died. Only 4% of the cases have occurred in people known to be fully vaccinated.

    Measles Is A Severe Disease

    Measles is fatal in approximately one to three of every 1,000 unvaccinated children. About one out of every 1,000 children will develop swelling of the brain, which can lead to long-term hearing and cognitive problems. Measles also has been associated with long-term defects in the immune system, leading to increased susceptibility to other infections later in life. And, according to the American College of Obstetricians and Gynecologists, measles infection during pregnancy can lead to increased risks of preterm delivery, low birth weight and miscarriage.

    Measles Is Vaccine-Preventable

    Measles is almost completely vaccine-preventable. In the U.S., the vaccine is administered as part of the measles mumps rubella shot. A two-dose series is recommended, with the first dose ideally being administered in children between the ages of 12 and 15 months and the second dose being administered around 5 years of age. The shots also can be administered to older children and adults who were not previously vaccinated.

    This vaccine is incredibly effective, providing about 97% protection in fully vaccinated people. And protection is thought to be long-lasting.

    The proof is in the numbers. Before the first measles vaccine was licensed in 1963, an estimated 3-4 million people became infected annually, and 400 to 500 people died. Those numbers dropped precipitously as vaccination rates rose. Indeed, measles was declared eliminated from the U.S. in 2000. Sustained spread no longer occurred.

    The Measles Vaccine Is Safe

    The vaccine also is very safe, with only minor side effects typically reported. These side effects may include soreness at the injection site, a rash or a fever. In very rare cases, seizures have been reported, but these seizures have not been associated with any long-term complications. And multiple studies have found no link between the MMR vaccine and the development of autism.

    Vaccination Rates Are Declining

    Despite the safety and efficacy of the vaccine, and the potential severity of the disease, vaccination rates are declining. This drop is fueling the current outbreaks. Because measles is highly contagious, epidemiologists estimate that approximately 95% of a population must be vaccinated to prevent sustained transmission of the virus.

    Historically, the measles vaccination rate in the U.S. has been quite high. But the numbers are dropping. Researchers at Johns Hopkins University recently reported that MMR vaccination rates nationally declined over 2.5% in recent years, to 91.26%. And in some locations, the rates are dramatically lower. In Gaines County, the epicenter of the measles outbreak in Texas, only 82% of kindergartners have been fully vaccinated.

    Misinformation May Be To Blame

    Some recent drops in vaccination rates may be tied to the COVID-19 pandemic. Many people delayed routine preventative medical care. But a larger concern is the effect of widespread misinformation about vaccines. A recent survey conducted by KFF showed that 63% of adults heard or read that the MMR vaccine has been proven to cause autism, 33% heard or read that the MMR vaccine is more dangerous than contracting measles, and 20% heard or read that vitamin A can prevent measles infections. Moreover, between 20% and 25% of respondents thought that these statements were definitely true or probably true.

    These statements are false.

    The repeated amplification of falsehoods about the MMR vaccine specifically and vaccines generally, almost certainly will further erode public trust. This drop in trust probably will lead to further drops in vaccination rates. And as vaccination rates drop, the number of cases of preventable diseases will increase.

    The “record” number of measles cases recently reported by the CDC undoubtedly will be broken.

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  • Israeli drone strike kills one in southern Lebanon as tensions grow with UNIFIL

    Israeli drone strike kills one in southern Lebanon as tensions grow with UNIFIL

    BEIRUT: UNIFIL forces were attacked on Thursday by residents in the town of Aitat, south of the Litani River. The assailants claimed that the patrol had entered the Wadi Jilou area without being accompanied by a Lebanese Army unit.

    According to footage captured by eyewitnesses, a group of individuals blocked the patrol’s way, demanding that it return with a Lebanese Army escort. The patrol reportedly refused to turn back, leading to direct confrontations.

    In response, UNIFIL personnel threw smoke and tear gas grenades to disperse the crowd. No injuries were reported.

    The attack is merely the latest in a series of assaults targeting UNIFIL forces and carried out by civilians in strongholds.

    These incidents aim to prevent UN peacekeepers from entering private property to conduct inspections, a key component of their official mandate.

    The most recent renewal of UNIFIL’s mission in southern Lebanon included an amendment granting the force greater freedom of movement within its area of operations, in coordination with the Lebanese Army.

    The tensions peaked on Thursday, when a resident of the town of Hallousiyeh–Deir Qanoun an-Naher hit a UNIFIL soldier during a patrol. The incident was widely condemned by political leaders, and a judicial investigation was launched.

    The UN Security Council is scheduled to meet at the end of August to consider the Lebanese government’s request to extend UNIFIL’s mandate in the south.

    In response to the attack, UNIFIL spokesperson Andrea Tenenti said that a patrol of the UN Interim Forces in Lebanon was blocked and pelted with stones by “a group of individuals in civilian clothes” in the southern village of Wadi Jilu.

    “The group attempted to obstruct the patrol using aggressive means, including throwing stones at the peacekeepers,” he said.

    “The LAF was promptly informed and arrived on the scene shortly thereafter. The situation was quickly brought under control,” Tenenti added, referring to the Lebanese Armed Forces.

    Tenenti confirmed that the activity of the patrol was coordinated in advance with the LAF, in support of Lebanon’s implementation of Security Council Resolution 1701. The situation was initially calm, but individuals soon began throwing stones at the peacekeepers.

    “In response, UNIFIL personnel employed non-lethal measures to ensure the safety of both the patrol members and those present,” he said.

    “Freedom of movement is a core requirement for the implementation of UNIFIL’s mandate. This includes the ability to operate independently and impartially, as outlined in UN Security Council Resolution 1701. Any restriction on this freedom — while conducting operational activities with or without LAF — constitutes a violation of that resolution.”

    Tenenti urged Lebanese authorities to “take all necessary measures to ensure that its peacekeepers can carry out their duties without obstruction or threat.”

    The UNIFIL spokesperson confirmed that the international forces will continue to monitor and report breaches of Resolution 1701 impartially, in accordance with the Security Council’s mandate and the request of the Lebanese government.

    UNIFIL’s mandate shall “confirm the withdrawal of Israeli forces from southern Lebanon, restore international peace and security, and assist the Government of Lebanon in ensuring its effective authority in the area.”

    US Envoy Thomas Barrack concluded his two-day visit to Lebanon, which began on Monday, to discuss a mechanism for disarming Hezbollah and withdrawing illegal weapons south and north of the Litani River.

    He inspected the area south of the Litani River by air after meeting with Army Commander Gen. Rodolphe Haikal. At a press conference in Beirut, he praised the Lebanese Army and the key role it plays.

    The attack on the UNIFIL patrol drew widespread condemnation from Lebanese political figures. MP Bilal Abdallah underlined the importance of the peacekeeping mission, stating that “there is a major national interest in preserving its role.”

    MP Ashraf Rifi condemned the attack, saying: “Hezbollah is once again attacking UNIFIL. How can this be reconciled while pretending to accept the Resolution 1701 and evacuating south of the Litani River?”

    He urged the state to hold “the aggressors accountable” and move to a new phase where there is “zero tolerance” for those who violate international legitimacy and expose Lebanon to grave dangers.

    Meanwhile, Israeli forces continued targeting Hezbollah operatives. On Thursday, an Israeli drone struck a motorcycle on Mansouri Road in the Tyre district, killing one person and injuring two, according to the Lebanese Ministry of Health.

    At dawn, an Israeli drone launched an airstrike on a cafe and an aluminum workshop in the town of Yohmor al-Shaqif, in the Nabatieh District. The site had previously been targeted in a similar strike.

    Israeli army spokesperson Avichay Adraee said that “the strike targeted a Hezbollah military command center allegedly operating within a civilian building,” accusing the group of using the local population as “human shields” to facilitate attacks against Israel.

    Sky News quoted an Israeli security source saying that as long as Hezbollah maintains a military wing, operations in Lebanon will persist.

    “Every Hezbollah operative is a legitimate target. The Radwan Forces — Hezbollah’s elite unit — will be dismantled, whether by Hezbollah or by us. Their infrastructure, weaponry, and fighters remain targets throughout Lebanese territory,” the source told Sky News.

    The Israeli security source noted that “Hezbollah’s efforts to return south of the Litani River appear limited” and praised what he described as “significant efforts by the Lebanese army to dismantle the group’s weapons infrastructure.”

    On Tuesday night, the Israeli army claimed that a drone strike killed Hussein Ali Mezher in the town of Babliyeh, north of the Litani River.

    In an official statement, the army claimed that Mezher was overseeing rocket fire in the Zahrani sector as part of Hezbollah’s Badr unit. He was reportedly responsible for launching attacks on Israeli territory and was involved in efforts to rebuild the group’s artillery capabilities in southern Lebanon.

    Media reports on Thursday in Lebanese outlets suggested that Hezbollah has begun implementing a new organizational strategy aimed at consolidating several of its jihadi and executive units, along with institutions that share similar functions.

    This internal restructuring effort, according to reports, is intended to adapt to current realities, with the group reportedly seeking to streamline its operations, rationalize expenditures, and optimize its structure in response to evolving circumstances.

    The Israeli army announced on Wednesday the launch of “special, targeted” ground operations in southern Lebanon, targeting Hezbollah infrastructure in Jabal al-Blat and al-Labbouneh.

    Forces from the 300th and 9th brigades reportedly dismantled weapons depots and missile launch sites belonging to the group, aiming to prevent Hezbollah from “reestablishing itself in the area,” the army said.

    A Lebanese security source told Arab News that “the operations took place over the past two weeks, targeting sites in valleys and hills under Hezbollah’s security control, areas that remain inaccessible to the Lebanese army.”

    Lebanese Prime Minister Nawaf Salam confirmed last month that the Lebanese army had dismantled more than 500 weapons sites and depots in the area south of the Litani River.

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  • Perplexity launches Comet, an AI-powered browser to challenge Google Chrome; OpenAI expected to enter the space soon

    Perplexity launches Comet, an AI-powered browser to challenge Google Chrome; OpenAI expected to enter the space soon

    Two major AI companies, OpenAI and Perplexity, are entering the web browser market with their own smart, AI-powered browsers, taking direct aim at Google Chrome, which currently rules the internet with more than two-thirds of the global market share.

    Perplexity launches ‘Comet’

    Perplexity AI, which is backed by big names like Nvidia, Jeff Bezos, and SoftBank, has launched a new browser called Comet. Unlike regular browsers, Comet is powered by AI that canthink, act, andmake decisions for the user.

    Instead of searching and clicking through websites yourself, Comet allows users to ask questions and complete tasks using a chat-like interface. You can compare products, summarise articles, schedule meetings, and even manage complex tasks, all in one place.

    Comet is currently available only to users who subscribe to Perplexity’s $200-per-month premium plan. Wider access will be given through invites later this summer.

    Perplexity says it does not use your personal data to train its AI and stores most information locally, which may appeal to users who care about online privacy.

    However, the company is facing criticism from news organisations like Forbes, Wired, and the Wall Street Journal. They have accused Perplexity of using their content without permission. In response, Perplexity is starting a programme to work with publishers more fairly.

    OpenAI’s Browser on the way

    At the same time, OpenAI, the company behind ChatGPT, is getting ready to launch its own browser in the coming weeks, according to Reuters. It is expected to be a major step in OpenAI’s plan to become a bigger part of users’ online lives.

    OpenAI’s browser will reportedly keep users inside a ChatGPT-like chat window for many tasks, instead of sending them to different websites. This could change the way we browse by making it easier to do things like fill out forms or book reservations directly through the browser.

    Importantly, OpenAI’s browser is built using Chromium, the same open-source code that powers Google Chrome, Microsoft Edge, and Opera. That gives OpenAI a strong technical foundation, while also allowing them to control more of the browsing experience and data.

    Why it matters

    Google Chrome is used by over three billion people worldwide and plays a key role in Google’s advertising business by collecting user data. That data helps Google show more accurate ads, which brings in most of its money. If OpenAI or Perplexity can attract even a small portion of Chrome users, it could seriously impact Google’s dominance.

    In fact, a US judge recently ruled that Google holds an unfair monopoly in online search. OpenAI even said it would be interested in buying Chrome if Google is ever forced to sell it.

    (With inputs from Reuters)

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  • Hate season | Pakistan Today

    As happens every year, as soon as the month of Muharram began this year, online platforms and WhatsApp turned into battlegrounds, with sectarian lines drawn rather harshly. As a matter of routine, the ‘season’ is marked by comment sections overflowing with hate, old friends cutting ties, and neighbours becoming strangers.

    While respected scholars on both sides of the aisle have for long promoted harmony, there are many across social media platforms who are clearly more interested in fuelling such divisions. Encouraged by the divisive rhetoric of a few, many young minds begin to view ‘others’ with negativity, deepening sectarian misunderstandings.

    The initiative taken by the government in Punjab to form a cyber force for monitoring online hate during Muharram was, indeed, a timely step, but laws alone are not enough.

    The people — all of us — need to re-member that Karbala and its message are universal in nature. It is about truth, courage and humanity; not sectarianism. The teachings of Karbala should reflect in both our actions and words — online and offline. This is not too difficult a task.

    SHAFAQ ALTAF KAZMI

    KARACHI

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  • Guy In Parking Lot Sees Something Stuck Behind Car Grille — Then It Moves

    Guy In Parking Lot Sees Something Stuck Behind Car Grille — Then It Moves

    A man was walking through the parking lot of a shopping center in Australia when he noticed something odd. There appeared to be something stuck behind the grille of a nearby car — and then he realized it was moving.

    WIRES

    The Good Samaritan immediately contacted WIRES, then grabbed a tarp and an umbrella to try and shield the little animal from the sun while he waited for the rescuers to arrive. As the team assessed the situation, the owner of the car returned — and couldn’t believe there was a wallaby stuck inside her car.

    car in parking lotcar in parking lot
    WIRES

    “We believe the wallaby was probably crossing the road at high speed and went under the car and was flipped up behind the grille,” John Grant, a media spokesperson for WIRES, told The Dodo. “The vehicle owner didn’t even realise she had hit anything, so was shocked when she arrived back to her car to find the poor animal trapped behind the grille. She had driven from nearby, so it had been there for less than 45 minutes.”

    wallaby stuck in carwallaby stuck in car
    WIRES

    WIRES volunteer Mark Badger determined that it was too dangerous to try and remove the wallaby, later named Arnie, himself as the animals are prone to extreme stress that can lead to complications. Instead, he contacted Byron Bay Wildlife Hospital, and Dr. Brie Talbot arrived on the scene to sedate Arnie.

    Once he was sedated, the team was able to safely remove Arnie from behind the car grille. After checking him over, Dr. Talbot was shocked to discover the little wallaby somehow had no injuries from his ordeal.

    “He was nicknamed Arnie after Arnold Schwarzenegger due to his amazing ability and strength in surviving such a traumatic event unscathed,” Grant said.

    wallabywallaby
    WIRES

    Arnie was placed into the care of another WIRES volunteer, and within a day, he was eating and drinking normally and seemed to be feeling just fine. He was kept under observation for a few weeks to make sure he was completely OK, then he was released back into the wild, where he belonged.

    “Like nearly all rescues, he bounded off without a backward glance, which is always celebrated as a successful outcome by every wildlife volunteer,” Grant said.

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  • Trading firms Virtu and Citadel Securities clash over new options exchange

    Trading firms Virtu and Citadel Securities clash over new options exchange

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    Virtu Financial has come out against rival Citadel Securities’ attempts to block the opening of a new US options exchange, as the high-speed trading giant wades into a dispute over market structure that has sucked in some of Wall Street’s biggest names.

    The disagreement hinges on the implementation of a 350-microsecond so-called “speed bump” that US exchange operator IEX — made famous by the Michael Lewis’s bestseller Flash Boys — hopes will protect traders on its proposed exchange from buying and selling options at stale prices.

    This mechanism will allow IEX to cancel and reprice a small proportion of orders, but critics of the plan, including billionaire Ken Griffin’s Citadel Securities, say it would end up harming ordinary investors while enriching IEX’s shareholders and market makers.

    New York-headquartered Virtu on Wednesday wrote to the Securities and Exchange Commission in support of IEX, which says it wants to shield investors from the cost of latency arbitrage — the exploitation by high-frequency traders of the microseconds it takes prices to reflect broader market moves.

    Virtu’s intervention comes three weeks after Citadel Securities criticised what it described as IEX’s “nefarious” and “unlawful” plan “to introduce an unprecedented quote cancelling scheme” into the ballooning US options market, in a letter to the SEC.

    Retail broker Charles Schwab, the New York Stock Exchange and Nasdaq have also said that IEX’s plan to launch a new equity options exchange should not be approved. 

    But in its letter, Virtu said IEX’s proposal “represents a well-intentioned effort to advance” market transparency and improve “the investor experience”. 

    It added: “The introduction of new trading venues has the potential to promote competition, foster innovation and possibly deliver better trading outcomes for all market participants.” Virtu was co-founded by Doug Cifu and Vincent Viola, former chair of the New York Mercantile Exchange and the owner of ice hockey team the Florida Panthers.

    Citadel Securities and IEX have clashed before. In 2015, Citadel Securities sought to block IEX’s application for registration as a national securities exchange, writing at the time that a new entrant would “create confusion for the marketplace, and for retail investors in particular”. 

    Citadel’s attempt was ultimately unsuccessful, although 11 years later IEX remains a small player in US equities, with a market share of roughly 2.6 per cent, according to the firm.

    Citadel’s latest attempt to shut down IEX’s planned move into the options market has drawn the ire of pressure group We The Investors, which wrote to the SEC on the subject earlier this month.

    “Almost 10 years since the first comment letters were filed against the IEX Equities exchange application, and all we have are the same tired, recycled arguments,” said WTI chief technology office Dave Lauer in the letter.

    “It has become clear that despite critics’ attempts to rewrite history and pretend that there is no such thing as latency arbitrage, such arbitrage does exist, and exploits both geographical and technological latencies in order to earn profits for the fastest traders to the detriment of slower traders,” he added.

    John Ramsay, chief market policy officer at IEX, said: “For the people who complain that the quotes will be inaccessible, it’s worth asking inaccessible to whom and for what purpose. If the answer is they’ll be inaccessible to people who are using latency arbitrage, that is exactly the point.”

    Additional reporting by Jennifer Hughes

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  • Arsenal to pay world-record fee for Liverpool’s Olivia Smith – source

    Arsenal to pay world-record fee for Liverpool’s Olivia Smith – source

    Olivia Smith is set to become the first player in the women’s game to command a transfer fee of £1 million ($1.4m) as Arsenal seek to secure her signature from Liverpool, a source has confirmed to ESPN.

    The news was first reported by The Guardian and the move is set to establish Canada international Smith, 20, as the new world-record transfer.

    It is understood the fee exceeds the previous world record amount which Chelsea set when they signed United States defender Naomi Girma for $1.1m.

    The deal is subject to personal terms being agreed but Arsenal look to have won the race for the much-admired forward.

    Sources have told ESPN that Liverpool had previously rejected offers from Chelsea and Lyon before accepting Arsenal’s record bid.

    Sources added that it is part of Arsenal’s aim to strengthen their squad after their Champions League triumph, and also to lower the overall age profile of the squad.

    Information from ESPN’s Tom Hamilton contributed to this report.

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  • ‘Murderbot’ Renewed for Season 2 at Apple TV+

    ‘Murderbot’ Renewed for Season 2 at Apple TV+

    Apple TV+ will give Murderbot more time to watch his favorite shows.

    The streamer has ordered a second season of the series, which stars Alexander Skarsgård as the title character, a security robot who has to hide the fact that it has gained free will and guard its human clients on a dangerous mission — but who really wants just to be left alone to watch futuristic soap operas and figure out its place in the universe.

    The renewal for Murderbot comes a day ahead of the show’s first season finale, set for July 11. The CBS Studios show is based on the first book in Martha Wells’ Hugo and Nebula Award-winning Murderbot Diaries novel series. Chris and Paul Weitz adapted the book and serve as showrunners.

    “We’re so grateful for the response that Murderbot has received and delighted that we’re getting to go back to Martha Wells’ world to work with Alexander, Apple, CBS Studios and the rest of the team,” the Weitz brothers said in a statement.

    Added Matt Cherniss, head of programming at Apple TV+, “Chris, Paul, Alexander and the entire Murderbot team have delivered a brilliantly original, addictive, witty and vibrant adaptation that has captured the imagination of audiences everywhere. We can’t wait to unveil what’s next for Murderbot and, of course, Sanctuary Moon in season two.”

    Murderbot also stars Noma Dumezweni, David Dastmalchian, Sabrina Wu, Akshay Khanna, Tattiawna Jones and Tamara Podemski. Chris and Paul Weitz executive produce with Andrew Miano of their Depth of Field company, along with David S. Goyer and Keith Levine for Phantom Four. Wells is a consulting producer.

     

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  • Optimizing Lipid Lowering Drug Use Could Yield Major Clinical, Public Health Benefits

    Optimizing Lipid Lowering Drug Use Could Yield Major Clinical, Public Health Benefits

    Seth Martin, MD MHS

    Credit: Johns Hopkins Medicine

    New research is shedding light on a significant gap between the number of patients for whom cholesterol-lowering drugs such as statins are guideline-recommended and the actual number of patients who take them, highlighting the clinical and public health benefits of aligning hypercholesterolemia treatment with guidelines.1

    The simulation study used cross-sectional National Health and Nutrition Examination Survey (NHANES) data representing 131 million US adults and found actual lipid lowering therapy (LLT) use was significantly lower than the proportion of eligible patients for all therapies, including statins, ezetimibe, and proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i). Fully guideline concordant care led to expected additional overall median LDL-C reductions ranging from 37.2-48.5 mg/dL, yielding a 21–27% relative reduction in the risk of major cardiovascular events.1

    “High cholesterol is an important chronic health condition that silently claims far too many lives —there are millions of people walking around with this condition that don’t even know they have it, and then when it is recognized it too often goes undertreated. Evidence-based action is critical to close the gap and prevent devastating cardiovascular events,” senior author Seth Martin, MD, MHS, a practicing cardiologist and professor at the Johns Hopkins University School of Medicine, said in a statement.2

    Investigators note that although prior research has quantified undertreatment, these analyses leave several questions unanswered, including whether such gaps have narrowed with changes in the diagnosis and treatment of high cholesterol, as well as the magnitude of health care gains with improved LDL-C treatment.1

    To project anticipated improvements in treatment and outcomes under full implementation of US and European pharmacologic treatment recommendations, investigators conducted a simulation study using cross-sectional data from NHANES from January 2013 through March 2020.1

    Among the cohort, investigators estimated the number of individuals eligible to receive versus currently receiving lipid lowering therapy (LLT) after applying the following major guidelines and pathways:

    • the 2018 American Heart Association (AHA)/American College of Cardiology (ACC) guideline
    • The 2019 European Society of Cardiology (ESC)/European Atherosclerosis Society (EAS) guideline
    • The 2022 ACC Expert Consensus Decision Pathway on the Role of Nonstatin Therapies for LDL-Cholesterol Lowering

    Additionally, they estimated the expected reduction in LDL-C and major cardiovascular events.1

    A total of 4980 NHANES participants 40–75 years of age were eligible for inclusion, representing 131.1 million US noninstitutionalized adults. The median LDL-C in the weighted population was 114 mg/dL with 28% of individuals using any LLT, including statins, ezetimibe, or PCSK9i.1

    Investigators included 11% of patients in the secondary prevention cohort, defined as individuals with clinical cardiovascular disease, including those who self-reported coronary heart disease, angina/angina pectoris, myocardial infarction, or stroke; all other individuals were considered part of the primary prevention cohort, which constituted 89% of the study population.1

    Among 116.3 million adults eligible for primary prevention in NHANES, 23% received some LLT, primarily statins. Investigators noted many more patients were eligible for any LLT based on the 2018 US guideline (47%), the 2019 EU guideline (87%), and the 2022 US pathway (47%) than were receiving LLT.1

    Among 14.8 million adults eligible for secondary prevention LLT according to all 3 recommendations, approximately 10.1 million individuals (68%) received any LLT. In addition to marked underuse of statins, investigators pointed out non-statin therapies were underutilized for secondary prevention when applying all 3 recommendations, citing 0.7 million of 14.8 million individuals (4%) received ezetimibe compared with recommendations that 4.8–11.2 million individuals should receive such treatment.1

    They additionally noted no adults in the secondary prevention cohort received PCSK9i therapy for secondary prevention, as compared with their estimation that 12% of patients under the 2018 US guideline, 42% of patients under the 2022 US pathway, and 53% of patients under the 2019 EU guideline should receive this therapeutic class, representing 1.8–7.9 million US adults.1

    Further analysis revealed the additional overall median LDL-C reduction expected under fully guideline concordant care was 37.2 (interquartile range [IQR], 6.7–57.6) mg/dL, 48.5 (IQR, 33.0–69.9) mg/dL, and 46.8 (IQR, 7.2–67.6) mg/dL based on the 2018 US guideline, 2019 EU guideline and the 2022 US pathway, respectively, yielding a 21–27% relative reduction in risk of major cardiovascular events.1

    “These results add to a growing body of evidence that there are important shortcomings in the quality of care for common and costly chronic diseases such as high cholesterol, and that addressing those shortcomings would yield major public health benefits,” lead author G. Caleb Alexander, MD, a practicing internist and professor in the Johns Hopkins Bloomberg School of Public Health’s Department of Epidemiology, said in a statement.2

    References
    1. Alexander GC, Curran J, Victores A, et al. US Public Health Gains from Improved Treatment of Hypercholesterolemia: A Simulation Study of NHANES Adults Treated to Guideline-Directed Therapy. J GEN INTERN MED (2025). https://doi.org/10.1007/s11606-025-09625-0
    2. Johns Hopkins Bloomberg School of Public Health. Tens of thousands of heart attacks and strokes could be avoided each year if cholesterol-lowering drugs were used according to guidelines. EurekAlert! June 30, 2025. Accessed July 10, 2025. https://www.eurekalert.org/news-releases/1089372

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