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  • MCL-1 Discovery Reveals New Cancer Therapy Pathways

    MCL-1 Discovery Reveals New Cancer Therapy Pathways

    The research strengthens the potential of MCL-1 as a cancer drug target, which is currently the subject of clinical trials all over the world.

    While drug compounds targeting MCL-1 that have been developed to date are considered extremely effective at combating cancer, they have unfortunately also caused significant side effects in early clinical trials, particularly in the heart.

    Co-senior researcher Professor Andreas Strasser said the findings could help resolve the safety issues of drugs targeting MCL-1 that have hindered these promising treatments.

    “If we can direct MCL-1 inhibitors preferentially to tumour cells and away from the cells of the heart and other healthy tissues, we may be able to selectively kill cancer cells while sparing healthy tissues,” Prof Strasser, a WEHI laboratory head, said.

    The study also lays the groundwork for better combination therapies. By understanding the distinct pathways the protein influences, researchers can design smarter dosing strategies and pair MCL-1 inhibitors with other treatments to reduce toxicity.

    “This work exemplifies the power of discovery science,” said co-senior researcher Professor Marco Herold, CEO of the Olivia Newton-John Cancer Research Institute (ONJCRI).

    “The sophisticated preclinical models we developed allow us to interrogate the precise function of MCL-1, and to address fundamental biological questions that have direct relevance to human disease.”

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  • Samsung Introduces Future-Ready Mobile Security for Personalized AI Experiences – Samsung Newsroom Malaysia

    Samsung Introduces Future-Ready Mobile Security for Personalized AI Experiences – Samsung Newsroom Malaysia

    New innovations including Knox Enhanced Encrypted Protection, updated Knox Matrix threat response and quantum-resistant Secure Wi-Fi strengthen privacy and user control for upcoming Galaxy smartphones

     

    SEOUL, Korea – July 7, 2025 – Samsung Electronics Co., Ltd. today announced a new set of security and privacy updates rolling out with its upcoming Samsung Galaxy smartphones with One UI 8. These updates reinforce Samsung’s commitment to delivering powerful, trusted mobile technology in a rapidly evolving digital world by introducing new protections for on-device AI, expanding cross-device threat detection and enhancing network security with quantum-resistant encryption.

     

     

    Next-Generation Mobile Security for AI Personalization

    Samsung is introducing Knox Enhanced Encrypted Protection (KEEP),[1] a new architecture designed to safeguard the next generation of personalized, AI-powered features, as its latest innovation in mobile security. KEEP creates encrypted, app-specific storage environments within the device’s secure storage area, ensuring that each app can access only its own sensitive information and nothing more.

     

    Supporting Galaxy’s Personal Data Engine (PDE),[2] KEEP helps secure a user’s deeply personal insights – such as routines and preferences – that enable features like Now Brief and Smart Gallery search. These insights stay entirely on-device, protected by KEEP and further secured by Knox Vault, Samsung’s tamper-resistant hardware security environment. The result is a seamless foundation for Galaxy AI that delivers personalized intelligence while keeping data tightly contained and under the user’s control.

     

    KEEP’s system-level structure allows it to scale across Galaxy AI innovations. In addition to PDE, it now protects Now Brief, Smart Suggestions and other on-device features that rely on user-specific inputs – enabling more advanced AI experiences without compromising privacy. With KEEP, Samsung is redefining how mobile devices safeguard data in the background to elevate privacy from a setting to an embedded design principle.

     

     

    Smarter, More Connected Threat Response with Knox Matrix

    As AI becomes more integrated across the ecosystem, Samsung is advancing protections that offer not just stronger security, but greater transparency and control for users, with Knox Matrix leading the way. Through One UI 8, Samsung is evolving Knox Matrix to deliver more proactive and user-friendly protection for connected Galaxy devices. When a device is flagged for serious risk – such as system manipulation or identity forgery – it is designed to automatically sign out of the Samsung Account, cutting off access to cloud-connected services to prevent threats from spreading.[3]

     

    Users are notified across their connected Galaxy devices and guided to the ‘Security status of your devices’ page, where they can review the issue and take action. Even devices without the latest security status updates trigger a yellow-level warning, helping users respond before vulnerabilities grow.

     

    Together, these updates make Samsung Galaxy’s ecosystem-level protection more dynamic, intuitive and visible, empowering users to maintain trust across all their devices with more confidence and clarity.

     

     

    Secure Wi-Fi Strengthened with Quantum-Resistant Encryption

    In continuation of its commitment to quantum-safe security, Samsung is bringing post-quantum cryptography to Secure Wi-Fi,[4] extending the trusted approach first introduced on the Galaxy S25 series through Post-Quantum Enhanced Data Protection (EDP). Secure Wi-Fi is now being upgraded with a new cryptographic framework[5] designed to strengthen network protection against emerging threats, particularly those anticipated in the era of quantum computing. This enhancement secures the key exchange process at the core of encrypted connections, helping ensure robust privacy even over public networks.

     

    Quantum computing, once fully realized, could undermine many of today’s data protection methods. By integrating post-quantum cryptography, Secure Wi-Fi is built to withstand future attacks that capture encrypted data with the intent to break it once quantum technology matures – a tactic known as “harvest now, decrypt later.” This upgrade fortifies the secure tunnel between Galaxy devices and Samsung servers, reinforcing the integrity of data transmissions in high-risk environments like public Wi-Fi.

     

    In addition to this future-ready foundation, Secure Wi-Fi offers a suite of advanced privacy features:

     

    • Auto Protect: Automatically activates in public places like cafés, airports or hotels, securing Wi-Fi connections without requiring user action.
    • Enhanced Privacy Protection (EPP): Encrypts internet traffic and routes it through multiple layers, combining packet encryption and relay to anonymize device information and help prevent tracking.
    • Protection Activity: Provides visibility into protection history by showing which apps and networks were secured and how much data was encrypted over time.

     

     

    A Trusted Platform with Built-In Safeguards

    In addition to its latest innovations, Samsung continues to strengthen the core protections that underpin the Galaxy experience. These features reflect a multi-layered security approach that protects across hardware and software, while giving users greater visibility and control:

     

    • Knox Vault secures sensitive credentials such as passwords, PINs and biometrics in a physically isolated environment, helping to keep them protected even if the main operating system is compromised.
    • Auto Blocker helps provide defense by default, blocking unauthorized app installs, restricting command-based attacks and mitigating risks from potential zero-click threats.
    • Advanced Intelligence Settings gives users the option to turn off online data processing for AI features, so personal information can stay on-device, fully under their control.
    • Enhanced Theft Protection helps protect personal data even in high-risk situations such as robbery, using safeguards like Identity Check and Security Delay to prevent unauthorized access.

     

    This latest set of updates reinforces Samsung’s long-standing commitment to mobile security that evolves with innovation. It strengthens on-device privacy for personalized AI with KEEP, expands transparency and user control through Knox Matrix, and introduces quantum-resistant protection to Secure Wi-Fi for a more future-ready Galaxy experience. As new security challenges emerge, Samsung remains focused on delivering safeguards that are built in, always on and ready for what’s next.

     

     

     

    [1] Available on Galaxy smartphones and tablets with One UI 8 or later.
    [2] The Personal Data Engine functions when the Personal Data Intelligence menu is on. Analyzed data will be deleted once the Personal Data Intelligence menu is turned off.
    [3] Available on Galaxy smartphones and tablets with One UI 8 or later. Availability may vary by model and/or market.
    [4] Secure Wi-Fi offers free protection of up to 1024MB per month for Android OS 13 or later, and 250MB per month for Android OS 12 or earlier versions. Availability details may vary by market or network provider and connectivity is subject to applicable network environments.
    [5] This upgrade applies a post-quantum cryptographic algorithm certified under NIST FIPS 203 (ML-KEM). Availability may vary by market, model, and OS version.

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  • Producing Hit Songs in the Age of AI – Terms of Service with Clare Duffy

    Producing Hit Songs in the Age of AI – Terms of Service with Clare Duffy

    This is Terms of Service, I’m Clare Duffy. Today, we’re going to do a little thought experiment. Think about a song you’ve had on repeat lately or one you can’t get out of your head. Do you know the story behind that song? Any behind the scenes details from the artists who produced it? And what if you found out that song or even just the melody was generated by someone feeding a prompt to AI? Would it change how you feel when you listen to it? The music industry is yet another place where AI is changing the game. AI tools are poised to transform the way music gets written, recorded, and produced. And artists have mixed feelings about it. To better understand what all of this means for the future of music, for the people making it, and those of us listening to it, I talked to Harvey Mason Jr. He’s the CEO of the Recording Academy and the Grammy Awards. Harvey has created music with Beyonce, Aretha Franklin, Whitney Houston, Justin Bieber, Ariana Grande, and Elton John, among many others. He has a deep understanding of what makes a song a hit, and he has plenty of thoughts on what musicians need to do to thrive in this age of AI.

    Well, Harvey Mason Jr., thank you so much for being here and doing this with us.

    Harvey Manson Jr.

    00:01:24

    My favorite thing to do, we’re going to talk about music, tech, it’s good to be with you, Clare.

    So you are a producer, a songwriter, but you’re also the CEO of the Recording Academy and the GRAMMYs.

    Harvey Manson Jr.

    00:01:35

    I know, it’s weird, right?

    What does that entail? What does it mean?

    Harvey Manson Jr.

    00:01:38

    I’d been writing songs my whole life. I’d be in the studios since I was a kid growing up around the community. And I got the opportunity to serve the community as first the board chair of the recording academy and then the CEO. So very different mindsets, different hats, but at the end of the day, I love music. I love the people who make music and I really believe in the power of music and what it means to our world and society at large and just how we interact with each other. You could have the worst argument in the world, but if you go to a concert and you stand next to somebody and the music’s playing, you start dancing, you start singing, it just changes everything about your makeup. So that’s the reason I’m in the role, and that’s how the commonality between producing music and making it and sharing with people and protecting and serving others that create it is kinda how they tie together.

    Got it. So this role, in part what you’re doing is advocating for musicians and artists.

    Harvey Manson Jr.

    00:02:29

    100% advocating, serving, lifting, showcasing, highlighting, all that. It’s every day I wake up hoping to do a better job of that than the last.

    And when did you sort of realize that AI was really going to be impacting the music world? Do you remember the moment that this dawned on you?

    Harvey Manson Jr.

    00:02:48

    Of course, it’s like when you saw the lunar landing, or when you saw an assassination of a president, almost as that serious for creators. I remember being in the studio and somebody saying, have you seen such and such application and how it works around music creation? I said, no, I haven’t seen it. Pulled it up on the laptop, typed in a few things, and it started spitting out music.

    Harvey Manson Jr.

    00:03:09

    Before that, I had seen it in other iterations, not quite as advanced, you know, maybe things that could enhance a vocal or things that can create a drum loop or a chord progression. But when I started seeing it make whole tracks and whole songs with singers and vocals and arrangements, it freaked me out. I really had to stop my tracks and say, what does this mean?

    So just to sort of set the stage here, will you give us the cliff notes on what it takes to make a song? Like what kinds of human inputs are required to get something that we hear on the radio?

    Harvey Manson Jr.

    00:03:42

    It’s countless decisions and choices and a series of compromises and trying to get what’s in your head out can take a lot of different forms. Some people sit at a piano, start playing chords and then start singing melodies and start thinking of words. Other people use computers, different digital audio workstations to record MIDI information and build tracks piece by piece, but it’s thousands of decisions, everything from what notes you’re playing, what chords you’re paying, what’s the tempo? What’s the key? How many instruments do you have? What’s the drum pattern? What’s base pattern? How do you fit the lead vocal over the track? What are you saying? How are the melodies flowing? What key, you know, there’s so many critical decisions that go into making a song. And up until this point, you’ve had to had some real specific musical or traditionally musical concern talent to be able to do all those things. You had to be to play an instrument. You had be able have an ear for what you liked. You also had to, most of the time, at least for me, I’m hearing something in my mind that I’m just trying to figure out how to get it out. So that comes from somewhere else and then we don’t know where that comes from or at least I don’t. And to be able to figure out how express that is I guess up until this point what’s considered a traditional music creating talent.

    And based on the tools, the AI tools that you’ve seen, how are those different? Like, what are those changing or replacing in the process? Potentially all of that?

    Harvey Manson Jr.

    00:05:03

    You nailed it, it’s replacing all of it. It’s replacing the composing part, the coming up with the chords, it’s the replacing the production of arranging and deciding the layering and what kind of instrumentation and rhythms go well together, which ones don’t. It’s replaced melody creation, lyric creation. It has gotten to the point where anyone you know, or anyone that knows how to use a laptop in the most basic form, typing a sentence, even if you’re on your phone, texting. Those people can create music using AI.

    ‘Do you have a sense of what it takes to make good AI-generated music? Like, surely anybody can type into one of these programs, but is there a difference between somebody who knows how to use them to make something that sounds like it might pass for human-created music? Or is it really just that easy that anybody could do it?

    Harvey Manson Jr.

    00:05:54

    In some instances, it’s that easy. If you get lucky based on what your prompt is and what it gives back, it has been known to create some really, really interesting, compelling pieces of music. The better you are at producing and writing songs and being a creator, to me, I believe you can have an effect on the output of the AI. You’re generating pieces, you’re giving it feedback, you’re connecting things to other things, and the way the software’s progressing, you’re gonna be able to create sections. And then it comes down to taste. Does this go well with this? I don’t like this. Let me try five or six others. Connect these. I don’t like this lyric. I don’t like this melody. And be able to interchange and exchange pieces of the song. That’s probably the next iteration of how AI is going to be going forward right now. You kind of give it your best shot at a prompt. It kicks something out to you. And a lot of times you can go back and change it. Let me speed it up a little bit. Let me slow it down a bit. Can you add a saxophone? These are the types of prompts you can do. So to answer your question, it’s a little relative because we need to have a conversation about what do you think is good music and how do you quantify that?

    What kinds of conversations are happening in the industry right now about this? Is it mostly anxiety? Is there any excitement?

    Harvey Manson Jr.

    00:07:05

    ‘Yeah, there’s a lot of excitement and it depends on who you talk to and it also depends on the day of the week. I think people swing wildly from complete panic and terror and fear around AI replacing everyone and disrupting the entire industry to AI is going to be the biggest windfall and boom for the industry since maybe streaming because they see the potential of AI as far as the positives, making more music and allowing more people to create music. I think is a great thing. And that’s why I’m excited about music. I am not an anti-AI person, I understand that AI is here, I understand how powerful it is, and I see the value in allowing people to be more creative, to come up with things maybe they didn’t think of originally, to be able to try things and demo a bunch of different ideas before they land on something they really, really love. And being an arbiter of taste is going to be really, really important. So that’s some of the positive stuff. The scary stuff is, what is AI learning on? Like is it being trained on copyrighted material that, you know, maybe I wrote a song 10 years ago and now people are using that to make their own songs. That’s got to be clarified and cleaned up with some legislation or at least some guardrails.

    Harvey Manson Jr.

    00:08:12

    Is it going to replace human creativity is a big fear. We hear a lot of that coming around from both musicians and songwriters and singers. And also, can it use your personal name, likeness, style, sound, voice? If I’m a producer and I produce a thousand songs, and I have a certain way of producing, can it listen to all my music and then say, hey, I want a song that sounds like Harvey Mason Jr. produced it, is that protectable? And so those are some of the conversations that I think everyone’s having from individual producers and writers all the way up to the corporate label owners.

    Obviously, and you mentioned some of them, we’ve seen technology come in and sort of evolve, transform the music industry before. There’s autotune, there’s a synthesizer. Does this moment feel fundamentally different? Is AI different from those other technologies?

    Harvey Manson Jr.

    00:09:00

    I think it is because I came up in a different time and I created music in a different time. I’m sure the generation that’s using it now thinks it’s the same as any other development or disruption in the industry. You know, piano players were scared to death of the piano role. You now, the player pianos where you put the thing on would play by itself. They said, oh, it’s gonna get rid of all piano players, you know, and that was a real thing. And then, when the synthesizer came out, everyone was afraid that there’d never be any more orchestras because it could simulate an orchestra or a violin player. I’m sure right now, to us, it looks like AI is so dissimilar to any of those other analogs, but I think in the future, as we start to wrestle with what it means for us as creators and we start adapt to it, because for me, that’s what I fall back on, creators and people who make art and make music. We’re very, very perceptive, and we’re also resilient. We take what we have and we figure out how to use it, and we make great new stuff with it. So I do think that once it settles in, that this is where music is going, we’re gonna figure out how to do it the right way. I believe in the work we’re doing at the Academy to make sure human creativity is protected, and human artwork that’s been copyrighted or protected is continuing to be protected. So there’s a few things that have to happen, but I’m still optimistic that this can be a way of expressing ourselves musically in a way that had not been done up to this point.

    Do you think that there is a real risk that human artists get replaced by AI, or that it makes an already competitive industry that much more competitive? It sounds like maybe that’s part of what’s fueling the work that you’re doing right now.

    Harvey Manson Jr.

    00:10:31

    It’s definitely going to make it more competitive. I don’t think there’s any question about that. And I’m already pretty positive it’s the most competitive industry in the world with so many millions of people making music. As far as if it’s going to replace human creativity, that’s really the struggle for me. Because I don’t believe human creativity can ever be replaced. I believe what we have lived and experienced in our lives, how we’ve grown up, how we been domesticated, how been in relationships, our interpersonal interactions make us who we are and we express that through our songs. Having said that, I’ve seen AI copy what humans can do. So, it’s not going to be exactly human, but I’ve seen it learn pretty darn well how to emulate or even predict what somebody’s going to think or say and then put that on a song, lyrically, emotionally. So, I don’t have the answer. We can be replaced. I like to believe we can. Because I think we’re inherently very special and we’re emotional and we have things that I don’t think any computer can ever do. But I do believe we have to be competitive. I think that we have figure out how to use this technology. I don’t think we should be hands off and say, oh, I don’t like AI, ban it. I think better get invested, better get our hands on it, figure out to use it and put it to use for our creative community and make sure that it’s protected. Copyrightable, it’s monetizable. Make sure anything learning backwards is taking care of the people it’s learning from and anything we make forward is getting approval or royalties of the right people. So I’m optimistic but scared at the same time.

    Have you started making music with AI yourself?

    Harvey Manson Jr.

    00:12:07

    I use AI all the time, I will say I use it in business, I use it in music, I used it in writing, and I’ve tried to adopt my own advice, which is get into the AI and see what it does, see what the capabilities are, how can I use it, because what’s going to differentiate one songwriter from another, one producer from another is how we interpret the technology and how we utilize it to make something great. And I said it earlier, but I do believe taste is going to come into play. Some expertise about music and knowledge about how things go together will help, but AI does a lot of that for you. So it’s going to come down to making sure you have a bit of a finger on the pulse of what consumers like, and if what you’re making happens to align with what people like, that will put you in a place where you can be successful. So the earlier you get your hands on it and figure out what it can do, the better.

    ‘So I know the Recording Academy has started to sort of evolve its thinking around the GRAMMYs in particular, music that includes AI components can win awards, but not for those AI components, if I’m understanding it correctly. Do you imagine that we might one day see an AI-generated music category at the GRAMMYs?

    Harvey Manson Jr.

    00:13:18

    I won’t say never, but I don’t imagine we would, just like we don’t see a category at the GRAMMYs that says best synthesized record and best organic instrument record. I believe if we can figure out all the legal issues and some of the other challenges we have with AI, I believe that AI will be used as a tool to create more music that hopefully The Academy can continue to honor, honor accurately. We’ll still have different genres and different styles of music, but AI will be the tool that helps really creative and talented, passionate people make their next version of art.

    So, you’ve touched on this, but I want to talk about the protections that artists are going to need going forward. We’ve already heard these concerns from artists that their music is being used to train these systems that could maybe replace them at some point. Talk to me about the NO FAKES Act. I know that you’ve been on Capitol Hill advocating for that, why do you think that that’s the right approach?

    Harvey Manson Jr.

    00:14:15

    I’ve been on Capitol Hill more than advocating. I’ve jumping up and down, waving my arms, saying, we’ve got to pay attention to this. It took me a long time to perfect my craft and get to the point where anyone wanted to hear my music, let alone liked it. So I’m not comfortable with just giving that to somebody and letting them do whatever they want with it and learning from it and creating new material off of that. So, personally, I am invested in making sure that this goes the right way. And the Academy, we represent 23,000 plus members that are different phases of the industry, whether it’s engineers or writers or artists. And we all believe the same thing, we have to protect our intellectual property properly. And so that does involve creating legislation or advocating for legislation. We’ve got some success on the state level in California, Illinois, and Tennessee, where we passed something that was called the Elvis Act, but it really is, how do we protect the name, likeness, and voice of singers and artists? And so that’s a bit of legislation we’re working on. Federally, it’s called the NO FAKES Act, as you said. We have some support. I don’t see a lot of dissension for it. It’s pretty much been supported across both sides of the aisle. And I hope that it can get introduced this year because I think it’s an important landmark for us to be able to say, AI, you cannot take a person’s voice and use it any way you want. And somebody else can’t prompt a voice to sound like an artist. That’s not okay.

    Do you imagine that, assuming that legislation passes, are there artists who are interested in saying, I’m willing to let other people use my voice as long as I get some credit or some money from that?

    Harvey Manson Jr.

    00:15:56

    It’s great. Every artist should have the opportunity to do with their voice what they want, not what somebody else wants. If you want to have AI use it, you should be able to, as long as you have the things that you need, approval, remuneration, credits, those are the kind of things that we have to make sure. Because right now, I can make a song, I could make a vocal version of you, Clare, and do an interview in your voice and put it on a podcast. And you can say nothing about it.

    Harvey Manson Jr.

    00:16:20

    I can make a song that sounds like my favorite artist and write it myself, sing it myself in my bad singing voice and put that artist voice over mine and put it out.

    Harvey Manson Jr.

    00:16:29

    I don’t have to ask them, I don’t have to credit them, I don’t have to pay them. So this is why the NO FAKES Act is so important.

    We will continue this conversation after a short break.

    Okay, something I’m personally really curious about, we know that there is so much power in learning to play an instrument, even if you’re not a professional artist, it’s this emotional sort of expression, it can create community. Do you worry that with AI people might stop wanting to learn how to play music even just for themselves? Do we lose something if that happens?

    Harvey Manson Jr.

    00:17:04

    Personally, I think yes, we do. Playing an instrument is important. The development of what that means to you and the creative side of your emotional personality, the development in your brain of what music means to someone who learns how to play an instrument is proven. Having said that, the people who used to criticize DJs and people who played turntables and then people who now tour the world playing music out of the laptops They would say oh those aren’t musicians those aren’t creators and clearly they are and clearly they’re incredibly amazingly talented at what they do. So my hope is that we can continue to have people who play traditional instruments, guitar, the piano, the bass, the drums many many others that I’m not mentioning, but also have people who create music in a new way and I’m sure young people who come up on the laptop prompting AI, aggregating different ideas, putting things together, compiling sounds, and making music, they’re going to believe that they are musicians. And to me, it’s a fundamental question that maybe we can ask your audience to consider, is anyone who makes music a musician?

    ‘Right. I’m fascinated by this. What do you think? Like, if you are just typing a prompt into AI and music spits out, maybe we won’t ask if that person is a musician, but is that the same as human-created music or is it something else?

    Harvey Manson Jr.

    00:18:26

    ‘No. That’s not the same as human-created music. It is music.

    Harvey Manson Jr.

    00:18:31

    But who’s to say what’s the right music, or the best music, it really depends on who’s listening. And who do people want to listen to? If something sounds great and it resonates with you as a listener, as a consumer, do you really mind where it comes from? That’s a question, a philosophical question that I don’t have the answer to. But I believe people less and less care about the technical side of how the music was made. And we saw the example two years ago when the first kind of bits of AI, there was a song that came out that kind of took the voice of two artists and put it together. It got a couple hundred million streams in two weeks.

    This was Drake and The Weekend.

    Harvey Manson Jr.

    00:19:09

    Right and some of it was probably curiosity, but also some of it was people just thought it was a cool song. So it’s gonna be something we’re gonna have to contend with. I definitely don’t have the answers. It’s a very complex subject. It’s gonna play out pretty quickly because the technology’s here and it’s evolving so fast.

    What advice do you have for artists who are interested in experimenting with this technology but also don’t want to lose too much of their voice or their control over the process?

    Harvey Manson Jr.

    00:19:37

    I would say make your art however feels right to you. I don’t think anybody has to do one or the other. Personally, I do believe that AI is gonna be involved in the future of creativity, whether it’s music or film or photography or image generation, I believe that. But if you choose to not do that and use it, then I support that because making music is the purest form of expression. And if you feel like you need to express yourself on a banjo you should do that. If you want to do it on a computer, you should do that. To me, I don’t discriminate. If you can make great music and if you can say things that are important and say things that move somebody either to, you know, love someone else or to cry or to have a party or to wake up and dance, I’m not so precious about how you did it. I would like to think that traditional musicianship can continue because I think it’s important. My father was a musician. I’m a musician. So, I like to think that that’s a thing, but also I’m not gonna have my head stuck in the sand to think, that’s the only way we have to make music.

    Do you expect that we’ll see a surge? I mean, obviously it’s already such a big business, but in more people wanting to go see live music in person?

    Harvey Manson Jr.

    00:20:49

    I hope so. I think it could. The more that you don’t know where the music comes from or who created or how it was created, the more maybe people will wanna go and see the actual person performing and the manifestation of the creativity you’re hearing on a streaming platform. Now you can experience and witness it firsthand. I hope there’s a huge appetite for that. I know I love that. There’s nothing better than seeing an artist just pour their heart out on a performance. I mean, what beats that?

    As a sort of groupie for my husband and I followed the Tedeschi Trucks Band around.

    Harvey Manson Jr.

    00:21:20

    Oh, wow, nice.

    And it’s like, yeah, you just can’t beat seeing 12 artists on the stage performing live, in my mind.

    Harvey Manson Jr.

    00:21:27

    I agree.

    But are there other things that individual music consumers, music lovers can think about if they want to continue supporting human artists? Maybe regardless of how they’re producing the music, but if it’s important to them to continue to support the humans that are making it.

    Harvey Manson Jr.

    00:21:45

    ‘The time that that question’s gonna be even more appropriate is when we start seeing AI artists. Right now we’re seeing AI-generated music that humans generally are singing. When we start having AI artists, then we’re gonna have to make a decision as consumers and listeners, do we wanna support computer art or do we want to support human art? And at that point, it’s just making that decision. There are producers that are right now talking about signing, creating, I guess I’ll say creating and signing, AI artists. Absolutely. You can go across your social media feeds. There’ll be producers, big producers that I love and respect that are creating AI artists and I can’t blame them because the ability to write a song now and have it performed by somebody that you have created and detailed and you’ve manipulated to sound just the way you want it to sound is really cool. It’s what we all try to do as producers, whether it’s an artist that assigned us or an artist that we’re working for, we’re always trying to get the music to sound just the way we want it. So to be able to do that with an AI artist is powerful. So that’s gonna happen. And at that point, it’s gonna come back to that question, do you just listen to stuff you like and don’t concern yourself with where it came from or who did it? Or do you try and support that human creativity? And I don’t know what’s gonna happened. We’ll see.

    Is that like in the next year we could be hearing music from AI artists?

    Harvey Manson Jr.

    00:23:03

    You’re hearing music from AI artists probably already.

    Harvey Manson Jr.

    00:23:06

    ‘You might not know about, but you’ll start seeing more high-profile artists with names and pictures and album cover artwork and things like that that producers will get behind and labels will probably get behind. So I think it’s going to happen.

    ‘What’s one thing that you hope people keep in mind the next time they hear or see something about AI-generated music going forward?

    Harvey Manson Jr.

    00:23:30

    I would hope when people hear something about AI, it makes them realize that there’s still got to be somebody making creative decisions. Right now, I think the word around AI is that it’s just replacing all human creativity. My hope is that AI and the technology around AI, generative AI for music, is that there still going to be the need for humans who have a musical ear or talent for gaging what people will like, or a creative sense about what’s great and what sounds exciting. My hope is that those people can still thrive. So as you’re listening to this conversation on AI, let’s try and remember in my ideal world, there’ll still be somebody that’s a producer or a songwriter, a tastemaker, somebody who’s using that technology in a way that’s different from everybody else, creating something that no one’s ever created before and expressing themselves in a new way that’s maybe not any better or any worse than the way we used to express ourselves. We’ll see.

    Do you have a message for the AI companies about how you’d like to see them act going forward when it comes to this issue?

    Harvey Manson Jr.

    00:24:43

    Yeah, I would say it sure would be nice if we could remember humanity, remember the people you grew up listening to their music when you were nine, 10, 15 in high school, going through your life experiences and living through the soundtrack of those humans that made that art and remain respectful of those people and make space for them to continue to be able to own and control their copyrights. And also make sure that we’re doing it the holistic view of what making music is, like let’s be sensible, let’s think about not just how fast we can crank out music but also how special we can make things and we can allow humans to express themselves. And I tend to think that the people running these platforms, I met with one of them last week, he’s a music person, he loves music, and he used to sing and…

    Can you tell us who it is?

    Harvey Manson Jr.

    00:25:36

    No, I’m not going to say who it is.

    Harvey Manson Jr.

    00:25:39

    But he loves music, so I believe they’re trying to find a way to make more music and allow more people to make music. I just hope we can remember at the base of all of it is human art, human creativity.

    Well, Harvey Mason Jr., thank you so much for doing this. This is a really fascinating conversation.

    Harvey Manson Jr.

    00:25:54

    Yeah, we could go all day about this, it’s not stopping.

    Harvey Manson Jr.

    00:26:00

    Yeah!

    ‘So whether you’re a musician, a producer, or just an avid playlist maker, here are some things to keep in mind. Whether you were aware of it or not, you’ve probably heard music by now that was generated, at least in part, by AI. Studios are already starting to create AI artists, so you’ll likely hear more and more of this. Still, Harvey says that AI can’t replace the spark of real-life creative collaboration. Or the human ear for what actually makes a piece of music compelling. At the end of the day, human decisions are still at the heart of a good song. As this technology continues to evolve, musicians do face a growing risk of their intellectual property and even their actual voices getting used without their permission. The proposed NO FAKES Act is one piece of legislation that’s trying to help artists protect themselves by holding companies and individuals liable if they create an unauthorized replica of an artist. Thanks for listening to Terms of Service. I’m Clare Duffy. Catch you next week.

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  • Elly Griffiths awarded Theakston Old Peculier Outstanding Contribution Award 2025

    Elly Griffiths awarded Theakston Old Peculier Outstanding Contribution Award 2025

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  • Michelle Agyemang: Sarina Wiegman says teenager can ‘bring something different’ to help England at Euro 2025

    Michelle Agyemang: Sarina Wiegman says teenager can ‘bring something different’ to help England at Euro 2025

    When Wiegman named Agyemang in the squad, she said the Arsenal forward could “bring something different” and she hoped she could show it in Switzerland.

    She impressed on loan at Brighton this season and Agyemang has been on Wiegman’s radar for a few years, having progressed through England’s youth teams.

    Agyemang appears calm in front of the cameras and mature beyond her years – but on the pitch she causes chaos.

    “I remember the first time she played because she flattened me in training. I was too slow on [the ball],” England captain Leah Williamson said last month.

    “I gave her a bit of stick about it, but in my head I thought: ‘You need to move the ball quicker, because she’s got something about her.’

    “My first impression was that she let me know she was there, which I love.”

    Agyemang wants to be a “unique player” and is striving for consistency, wanting to make an impact “from minute one to the end”.

    She takes inspiration from club-mate Alessia Russo and Chelsea forward Lauren James, who is “one of the most technically gifted players” she has seen.

    But there is one trait Agyemang is already becoming known for – her strength.

    “She just runs into people and bodies them because she’s so strong,” said Chelsea defender Lucy Bronze.

    “She’s so sweet and unassuming as a person, but then on the pitch she’s probably one of my favourites to play against because I can run into her dead hard!

    “She likes to give it back. She’s been told [by Wiegman] that she needs to go a little bit easier but I said: ‘No, just keep it up Micha, I prefer it, it makes it harder for us.’”

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  • Puffin to publish Andy Day’s first picture books

    Puffin to publish Andy Day’s first picture books

    Puffin is set to publish the first picture books from Dino Dad author Andy Day, with Alex Patrick as illustrator.

    Olivia Edwards, picture book editorial director at Puffin, acquired world rights to two titles from KT Forster at KT Forster Literary Agency, working with Craig Latto at Talent 4 Media Ltd. Deputy art director Clare Doughty acquired world rights to the illustrations from Nicky Lander at The Bright Agency.

    The first title – Dylan the Dino Boy Saves Christmas – will be published in paperback on 2nd October 2025. The publisher described it as a “warm-hearted and ROAR-some dinosaur Christmas picture-book adventure, full of Andy’s signature humour, energy and passion for all things dino-related, paired with vividly characterful illustrations”.

    Day said: “I have absolutely loved writing the Dino Dad series – as well as touring the UK meeting thousands of young readers and booksellers – and so I couldn’t be happier to be bringing my passion for dinosaurs to the incredible world of picture books and younger readers.

    “Reading with my own little ones is one of my favourite things, and it has been a very special experience sharing Dylan’s adventures with them as I’ve been writing this new story – I can’t wait for more families to meet Dylan, and I hope he will bring some dino-tastic magic to Christmas!”

    Day is one of the best-known stars of preschool television. He stars in the programmes Andy’s Adventures and Andy and the Band, which features Andy’s real-life pop band Andy and the Odd Socks.

    Continues…

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  • Every Cherry partners with CBeebies on SEND books

    Every Cherry partners with CBeebies on SEND books

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  • Switchable metasurfaces deliver stronger light control – Physics World

    Switchable metasurfaces deliver stronger light control – Physics World






    Switchable metasurfaces deliver stronger light control – Physics World


















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    Copyright © 2025 by IOP Publishing Ltd and individual contributors

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  • Lasting COVID-19 vulnerability in childhood cancer survivors

    Lasting COVID-19 vulnerability in childhood cancer survivors

    Study finds that even decades after beating cancer, survivors remain especially vulnerable to severe COVID-19, urging health authorities to rethink tailored protection strategies in future pandemics.

    Study: COVID-19 infection and severity among childhood cancer survivors in Denmark and Sweden: a register-based cohort study with matched population and sibling comparisons. Image credit: Frame Stock Footage/Shutterstock.com

    Childhood cancer survivors have a substantially higher risk of developing severe coronavirus disease 2019 (COVID-19) even many years after their cancer diagnosis, as reported by the first European and nationwide population-based study published in The Lancet Regional Health. 

    Background

    The prevalence of childhood cancer is rapidly increasing worldwide, with more than 400,000 children aged 0-19 diagnosed with cancer each year. Recent advancements in diagnostics and therapeutics have significantly improved cancer prognosis, leading to a 5-year survival rate of over 85% in high-income countries.

    With increasing survival rates, the number of childhood cancer survivors is steadily increasing globally. However, the risk of various health complications and premature mortality is significantly higher in this vulnerable population. During the COVID-19 pandemic, a substantially higher risk of severe COVID-19 and related mortality has been observed among individuals with a history of cancer.

    The evidence regarding the impact of the COVID-19 pandemic on childhood cancer survivors remains inconclusive. Only a few studies have been conducted on childhood cancer survivors, focusing mainly on psychological and lifestyle outcomes related to the pandemic.

    The current study aimed to investigate whether childhood cancer survivors are at a higher risk of developing severe COVID-19 and contracting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections compared to the general population.

    The study

    The study involved a total of 13,659 cancer survivors from Denmark and Sweden who were diagnosed with cancer before the age of 19 years. The risk of SARS-CoV-2 infection and severe COVID-19 in childhood cancer survivors was compared with 58,803 randomly selected individuals from the general population, matched on year of birth, sex, and country.

    Risk comparisons were also carried out between cancer survivors and their siblings to account for confounding family-shared factors. All participants were followed from January 2020 to December 2022.

    Denmark and Sweden were selected as participating countries because of significant differences in their pandemic responses. While Denmark implemented mandatory restrictions throughout the pandemic, including mask wearing, nationwide lockdown, and school closures, Sweden followed a more permissive approach, opting for recommendations rather than mandates.

    Key findings

    The comparison analysis between childhood cancer survivors and their counterparts from the general population revealed a similar risk of developing severe COVID-19 at the beginning of the pandemic.

    However, with the emergence of SARS-CoV-2 variants with higher transmissibility, such as the Alpha and Omicron variants, a higher risk of severe COVID-19 was observed among cancer survivors than their counterparts from the general population.

    While childhood cancer survivors faced a higher risk of severe COVID-19, they were less likely to contract SARS-CoV-2 compared to their matched counterparts from the general population. The risk was more evident among the comparisons during the transmission of the Omicron variant.

    The comparison analysis between cancer survivors and their siblings revealed a higher risk of developing severe COVID-19 and a lower risk of contracting SARS-CoV-2 infection among survivors.

    The country-specific analysis revealed an initial difference in severe COVID-19 risk between survivors and comparisons from Denmark and Sweden. However, with the emergence of variants with higher transmissibility, a higher risk of severe COVID-19 was observed among cancer survivors from both countries than their respective comparisons. Regarding SARS-CoV-2 infection, a higher risk was observed among comparisons than survivors in both countries.

    Although the relative risk (adjusted hazard ratio, aHR) of severe COVID-19 was higher in Sweden, the absolute proportion of survivors affected converged in both countries by the end of the study period.

    Study significance

    The study reveals that childhood cancer survivors had a 58% higher risk of developing severe COVID-19 than their counterparts from the general population (aHR = 1.58), and a twofold risk compared to their siblings (aHR = 2.02), despite having a lower risk of contracting SARS-CoV-2 infection and a higher vaccination rate.  

    The risk of severe COVID-19 was particularly noticeable among survivors with a childhood cancer diagnosis at the age of 15 years or older, survivors diagnosed with solid tumors, and survivors aged 50 years or above at the beginning of the pandemic. The increased risk was more evident during the Alpha and Omicron variant outbreaks.

    Previous studies involving high-risk populations have also described higher risks of severe COVID-19 among survivors of adulthood cancer. The findings of the current study indicate that childhood cancer survivors are particularly susceptible to developing severe COVID-19 during high-transmission periods, suggesting they could have benefited from being classified as a high-risk population and having tailored interventions, such as being prioritized when COVID-19 vaccines became available.

    Importantly, while the relative risk was higher, the absolute risk of severe COVID-19 remained low in both groups, with 0.8% of survivors and 0.4% of their comparisons being diagnosed with severe COVID-19 during the study period.

    Although Denmark and Sweden implemented different pandemic control measures, the study reported similar proportions of childhood cancer survivors with severe COVID-19 in both countries during high-transmission periods. The risk of severe COVID-19 remained high among survivors in both countries even after the introduction of the COVID-19 vaccine.

    This could be partly due to the lower protective efficacy of vaccines in immunocompromised individuals like cancer patients, as well as other factors such as behavioral differences, with survivors possibly taking greater precautions to avoid infection. Differences in testing rates between countries may also have influenced the observed infection rates.

    The study authors also note some limitations, such as the inability to stratify by specific cancer subtypes due to limited statistical power, and possible under-capture of comorbidities managed in primary care.

    Overall, the study provides valuable information to facilitate future pandemic preparations. The findings also highlight the need for tailored interventions to safeguard high-risk populations during future health crises.

    Download your PDF copy now!

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  • Matric results 2025 announced in Quetta, Balochistan

    Matric results 2025 announced in Quetta, Balochistan

    QUETTA: The Balochistan Board of Intermediate and Secondary Education has officially announced the Matric Annual Examination results for 2025, ARY News reported.

    Chairman of the Board, Muhammad Ishaq, made the formal announcement on Tuesday. Aftab Alam, a student from Balochistan Residential College, secured the first position with an impressive score of 1,051 marks. Muhammad Hashir clinched the second position with 1,043 marks, while Muhammad Tufail and Saqib Ali jointly secured the third position, each scoring 1,038 marks.

    A total of 148,114 students participated in the Matric Annual Examination, with 100,870 candidates successfully passing, according to Chairman Muhammad Ishaq. The overall pass percentage for the examination stood at 68.10%.

    In a separate development, earlier, the process of verifying matric and inter certificates in Sindh was shifted online, according to a notification issued by the Inter Boards Coordination Commission (IBCC).

    Read more: Matric, inter exams rescheduled

    As per details, under the new directive, all sealed envelopes containing certificates submitted for verification will no longer be accepted.

    Instead, verification will be conducted exclusively through an online system.

    The IBCC has instructed that all educational boards in Sindh must be linked with its platform to ensure seamless verification.

    Currently, the system is being implemented in the Karachi Matric Board, Sukkur Education Board, and Ziauddin Board.

    The remaining boards in Sindh have been urged to upload and digitize their academic records promptly to be integrated into the online verification mechanism.


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