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  • ecDNA discovery targets ‘zombie’ cells in childhood cancers

    ecDNA discovery targets ‘zombie’ cells in childhood cancers

    Researchers have discovered how circular extra-chromosomal DNA drives relapse in childhood cancers and found a way to target dormant “zombie” tumour cells – which could allow for the development of more durable treatments.


    Cancer remains the leading cause of disease-related death in childhood. One contributing factor is the presence of cancer-associated genes – known as oncogenes –that can exist far from chromosomes inside tumour cell nuclei. These genes often reside on ring-shaped DNA structures.

    These ring-shaped DNA structures – called circular extra-chromosomal DNA elements (ecDNA) – are fragments of DNA that have broken off from normal chromosomes and been reassembled incorrectly by DNA repair mechanisms. This process results in floating circles of DNA within cancer cells.

    “We have shown that these ecDNAs are much more abundant in solid paediatric tumours than we previously thought,” said Dr Lukas Chavez, an associate professor in the Cancer Genome and Epigenetics Program at Sanford Burnham Prebys. “And we have also shown that they are associated with very poor outcomes.”

    Linking ecDNA to neuroblastoma relapse

    In findings published in Cancer Discovery, an international research team looked into why a common paediatric cancer – neuroblastoma – can initially respond well to chemotherapy but later relapse – sometimes even years later.

    Cancer cells with numerous copies of the MYCN oncogene on ecDNA grow quickly but are more susceptible to chemotherapy. In contrast, cells with fewer copies of the oncogene on ecDNA can slip into a dormant, zombie-like state called senescence. These cells stop dividing but remain alive, unaffected by chemotherapy. Over time –sometimes a year or two later – they can reactivate, fuelling cancer recurrence.

    Targeting “zombie” cancer cells

    The researchers found that combining standard chemotherapy with another treatment designed to target senescent cancer cells significantly improved results in mouse models of neuroblastoma.

    Ashley Hui, a graduate student in the Chavez lab, demonstrated that this same phenomenon – low levels of ecDNA carrying MYCN leading to zombie-like cells – also occurs in medulloblastoma – the most common malignant brain tumour in children.

    Toward lasting cures

    The discovery of ecDNA’s role in driving relapse – and the potential to eliminate dormant “zombie” cells – could allow for more durable treatments for childhood cancers. By combining genetic discoveries with targeted therapies, researchers are moving closer to preventing recurrence and improving survival rates.

    “By integrating genomic analyses of tumour DNA with hypothesis-driven functional experiments and high-throughput drug screening, we aim to discover new drugs and drug combinations that halt tumour growth by eliminating these oncogenic DNA circles,” said Chavez.

    “Ultimately, our goal is to translate these scientific advances into more effective therapies and lasting cures for children with brain cancer.”

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  • Formula E Uses Cloud-Based Production Using Google Cloud & Techex Technology

    Formula E Uses Cloud-Based Production Using Google Cloud & Techex Technology

    Techex is collaborating with Google Cloud to deliver secure, low-latency transport of live video feeds from race circuits to global production partners. Techex has deployed a new cloud-based media production environment for Formula E, supporting the championship’s global live event coverage and media operations.

    The new production environment was designed to meet Formula E’s need for a scalable, flexible and secure cloud infrastructure to support its rapid event schedule. To meet this need, Techex’s tx edge software was deployed to act as the live IP transport layer across Formula E’s media workflows.

    Deployed in just a few weeks, the tx edge platform plays a big role in enabling Formula E’s cloud-based media ecosystem by securely transporting camera and program feeds to production partners worldwide and ingesting them into Formula E’s media asset management platform. With tx edge available through Google Cloud Marketplace, the Techex solution was easily accessible for integration into Formula E’s new vendor-agnostic environment.

    “The media industry is undergoing a rapid transformation, and cloud-based solutions are essential for driving innovation,” comments Justin Grayston, Head of Customer Engineering for UK/I Media & Entertainment at Google Cloud. “Our collaboration with Techex allows organisations such as Formula E to leverage Google Cloud’s AI, machine learning, data analytics and edge capabilities, enabling organisations to create richer, more personalised experiences for their fans and future-proof their operations.”

    As a selected participant in the IBC 2025 Accelerator Programme for the Master Control Cloud project—alongside champions RTÉ, BBC, BT Media & Broadcast, ITV, VSF, and SVT—Techex is contributing to the design and delivery of advanced cloud-based Master Control Room capabilities. The project presentation takes place on Saturday 13 September, 3:30–4:30.

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  • Six planets are hanging out in early morning skies this month. Here’s how to spot them

    Six planets are hanging out in early morning skies this month. Here’s how to spot them

    NEW YORK — Six planets are hanging out in the sky this month in what’s known as a planetary parade. Catch the spectacle while you can because it’s the last one of the year.

    These linkups happen when several planets appear to line up in the night sky at once. Such parades are fairly common, happening around every year depending on the number of planets. At least one bright planet can be spotted on most nights, weather permitting, according to NASA.

    Six planets were visible in January skies and every planet of our solar system was visible in February, but not all could be spotted with the naked eye.

    Venus, Jupiter, Saturn and a faint Mercury are visible this month without any special equipment, and the best chances to spot them are over the next week. Uranus and Neptune can only be glimpsed through binoculars and telescopes.

    Jupiter and Venus made a close brush earlier this week and are still near each other in the eastern sky, “close together like cat’s eyes,” said Carolyn Sumners at the Houston Museum of Natural Science.

    Mercury will be at its farthest point from the sun on Tuesday morning, making it easier to spot before it disappears into the sun’s glare.

    To catch the planets, go out in the morning shortly before sunrise and look east. Try to find Jupiter and Venus clustered together first. Saturn is off to the side and Mercury will be close to the horizon, trying to rise before the sun.

    “You’re looking for little tiny pinpoints of light, but they are the brightest ones,” said Justin Bartel with the Science Museum of Virginia. “They don’t really twinkle like the stars do.”

    Before heading out, make sure it is a clear, cloudless morning and try to get away from tall buildings that could block the view.

    Mercury will hide behind the sun again toward the end of the month, but a crescent moon will then join the parade. The next big planetary hangout is in February.

    ___

    The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education and the Robert Wood Johnson Foundation. The AP is solely responsible for all content.

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  • Philips Hue’s new bridge could turn your lights into motion sensors

    Philips Hue’s new bridge could turn your lights into motion sensors

    Smart lighting company Philips Hue appears to be launching a new version of its bridge, the first in a decade. According to a product page briefly published on Hue’s website and since removed, the Hue Bridge Pro will be faster, have more capacity, and can “turn your smart lights into motion sensors.” A Hue video doorbell, new outdoor lighting, and a more energy-efficient A19 light bulb are also on the way.

    The page, which was first spotted by HueBlog, outlined all the new products but revealed no specs or prices. Signify, Hue’s parent company, is hosting a press event in Berlin next month, ahead of the IFA tech trade show, where we expect full details.

    The standout news is the bridge’s new motion-sensing capability. Details are scarce, but the description mentions “built-in MotionAware technology.” Wi-Fi motion sensing technology has been around for years — Hue’s sister company Wiz uses it in its Wi-Fi bulbs — but Hue lights work over Zigbee, not Wi-Fi. In January, a company called Ivani debuted its Sensify wireless sensing technology, which can turn mains-powered Zigbee devices (like light bulbs) into motion sensors with a firmware update.

    A leaked image of the new bridge breaks down its tech specs, which include more RAM, a faster processor, and the addition of Wi-Fi.
    Image: Signify

    At the time, Ivani co-founder Justin McKinney told The Verge the company was working with “large household names poised to deploy the technology very soon.” It’s possible one of those companies is Hue, and that Sensify’s tech is powering the upgrade that could let your existing Hue bulbs and accessories act as motion sensors. This would make them capable of automatically adjusting your lights as you move through the house without the need for standalone motion sensors.

    The bridge will also have “advanced AI features,” likely tied to Hue’s new AI lighting assistant. According to additional reporting by HueBlog, the Bridge Pro will feature a faster processor, more RAM, the addition of Wi-Fi connectivity so you don’t have to plug it into your router, and support for up to 150 bulbs and 50 accessories — more than triple the current bridge’s capability.

    The first official picture of the new Hue Wired Doorbell shows a slim device with a prominent button surrounded by LEDs and the Hue logo beneath a camera.

    The first official picture of the new Hue Wired Doorbell shows a slim device with a prominent button surrounded by LEDs and the Hue logo beneath a camera.
    Image: Signify

    In addition to the bridge, Hue is preparing a new wired video doorbell, first leaked in March. A new image shows a design reminiscent of the second-gen August doorbell. The Hue website noted it will stream in 2K, an upgrade from the 1080p on Hue’s 2023 security cameras.

    Another confirmed rumor: Hue lights will soon be controlled by Sonos’ voice assistant. According to the page, you’ll be able to tell Sonos speakers to turn Hue lights on and off, dim or brighten, change their colors, or select a light scene. While Sonos Voice Control is more limited than Alexa or Siri, all commands are processed locally.

    The new flagship Hue A19 bulb features better energy efficiency and deeper dimming alongside improved color synching.

    The new flagship Hue A19 bulb features better energy efficiency and deeper dimming alongside improved color synching.
    Image: Signify

    Of course, there are new lights coming, too. The page reveals a new, more energy-efficient E26/A19 60-watt smart bulb that uses 40 percent less energy and dims as low as 0.2. percent. It supports Hue’s ChromaSync tech for more precise color matching when syncing across fixtures — a feature also coming to a new “family of indoor and outdoor light strips” with gradient lighting.

    Two new Festavia-branded outdoor lights are on the way: a set of permanent outdoor lights designed to be fixed to the outside of your house, similar to those offered by Govee and Nanoleaf, and a set of Globe String lights. The globe lights look particularly attractive, with each bulb featuring a “distinctive inner tube” that can be customized with light gradients, colors, and special effects.

    The Festavia Globe String Lights are soooo pretty.

    The Festavia Globe String Lights are soooo pretty.
    Image: Signify

    It’s an impressive lineup, but the upgraded bridge with motion-sensing technology is the standout. Not only should it strengthen Hue’s lighting system and support more devices, it could eliminate the need for dedicated motion sensors altogether. I’ll be in Berlin next month for IFA to see the official launch and get hands-on with these new products.

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  • Supporting asteroid defense: The 2025…

    Supporting asteroid defense: The 2025…

    I am excited to announce the latest round of winners of The Planetary Society’s Shoemaker Near-Earth Object (NEO) Grant program. Named after pioneering planetary geologist Gene Shoemaker, these grants support very advanced amateur astronomers around the world in their efforts to find, track, and characterize near-Earth asteroids. This round’s winners continue a long tradition of Planetary Society-supported planetary defense, protecting the Earth from the threat of asteroid impacts.

    Background

    Though dedicated professional telescopes make the majority of NEO discoveries now, they don’t have adequate observing time or geographical distribution. That is where our Shoemaker grant winners come in, making important contributions to three areas of planetary defense:

    • Characterization: Some winners focus on characterization to determine asteroid properties. They typically carry out photometric (brightness) studies to determine properties like spin rate and whether what looks like one asteroid is actually two — a binary pair. This type of information will be crucial when an asteroid deflection is required, and in the meantime, for understanding the near-Earth asteroid population in general.
    • Tracking: Other winners focus on astrometric (sky position) tracking observations that are necessary for calculating an asteroid’s orbit, including whether it will ever collide with the Earth. Without follow-up observations, newly discovered asteroids can even be lost.
    • Discovery: Because most professional NEO surveys that discover asteroids are in the northern hemisphere, there is still a need for discovery. Even with the new Vera Rubin Observatory, there will be a need for rapid follow-up tracking in the southern hemisphere. Around the world, software innovations are also increasing discovery rates.

    We are sincerely grateful to our expert advisory/review panel: Planetary Society NEO Grant Coordinator Tim Spahr, NEO Sciences LLC; Carl Hergenrother, Ascending Node Technologies, LLC; and Federica Spoto, the Minor Planet Center.

    Summary of awards

    Thanks to the support of our generous members, we were able to award $87,562 in this year’s round of grants, our largest amount ever for one round of Shoemaker grants. The home countries and observatories of the 10 winners (another record) are in eight countries on four continents. Over the program’s 28-year history, approximately $673,000 has been granted in 88 awards to astronomers in 23 countries on six continents. Here are summaries of the newest winners.

    Awardees

    Leonardo Amaral at the Observatório Campo dos Amarais (OCA) in Brazil is awarded $5,457 for a new computer with an advanced graphics card for image processing. OCA is an automated facility focused on searching and follow-up of NEOs, so far discovering 26 NEOs and one comet. It uses synthetic tracking techniques, which improve its ability to detect objects to magnitude 21. Its current limitation is image processing by a modest graphics card, restricting the speed and depth of searches. Improvements to the graphics card will increase efficiency and discoveries.


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  • The disappearing planet next door has astronomers intrigued

    The disappearing planet next door has astronomers intrigued

    Found using the MIRI instrument on NASA’s Webb telescope, which was managed by JPL through launch, the possible planet would be easier to study than more far-flung worlds.

    Astronomers using NASA’s James Webb Space Telescope have found strong evidence of a giant planet orbiting a star in the stellar system closest to our own Sun. At just 4 light-years away from Earth, the Alpha Centauri triple star system has long been a compelling target in the search for worlds beyond our solar system.

    Visible only from Earth’s Southern Hemisphere, it’s made up of the binary Alpha Centauri A and Alpha Centauri B, both Sun-like stars, and the faint red dwarf star Proxima Centauri. Alpha Centauri A is the third brightest star in the night sky. While there are three confirmed planets orbiting Proxima Centauri, the presence of other worlds surrounding Alpha Centauri A and Alpha Centauri B has proved challenging to confirm.

    Now, Webb’s observations from its Mid-Infrared Instrument (MIRI) are providing the strongest evidence to date of a gas giant orbiting Alpha Centauri A. The results have been accepted in a series of two papers in The Astrophysical Journal Letters.

    If confirmed, the planet would be the closest to Earth that orbits in the habitable zone of a Sun-like star. However, because the planet candidate is a gas giant, scientists say it would not support life as we know it.

    “With this system being so close to us, any exoplanets found would offer our best opportunity to collect data on planetary systems other than our own. Yet, these are incredibly challenging observations to make, even with the world’s most powerful space telescope, because these stars are so bright, close, and move across the sky quickly,” said Charles Beichman, NASA’s Jet Propulsion Laboratory and the NASA Exoplanet Science Institute at Caltech’s IPAC astronomy center, co-first author on the new papers. “Webb was designed and optimized to find the most distant galaxies in the universe. The operations team at the Space Telescope Science Institute had to come up with a custom observing sequence just for this target, and their extra effort paid off spectacularly.”

    Several rounds of meticulously planned observations by Webb, careful analysis by the research team, and extensive computer modeling helped determine that the source seen in Webb’s image is likely to be a planet and not a background object (like a galaxy), foreground object (a passing asteroid), or other detector or image artifact.

    The first observations of the system took place in August 2024, using the coronagraphic mask aboard MIRI to block Alpha Centauri A’s light. While extra brightness from the nearby companion star Alpha Centauri B complicated the analysis, the team was able to subtract out the light from both stars to reveal an object over 10,000 times fainter than Alpha Centauri A, separated from the star by about two times the distance between the Sun and Earth.

    While the initial detection was exciting, the research team needed more data to come to a firm conclusion. However, additional observations of the system in February 2025 and April 2025 (using Director’s Discretionary Time) did not reveal any objects like the one identified in August 2024.

    “We are faced with the case of a disappearing planet! To investigate this mystery, we used computer models to simulate millions of potential orbits, incorporating the knowledge gained when we saw the planet, as well as when we did not,” said Ph.D. student Aniket Sanghi of Caltech in Pasadena, California. Sanghi is a co-first author on the two papers covering the team’s research.

    In these simulations, the team took into account both a 2019 sighting of the potential exoplanet candidate by the European Southern Observatory’s Very Large Telescope, the new data from Webb, and considered orbits that would be gravitationally stable in the presence of Alpha Centauri B, meaning the planet wouldn’t get flung out of the system.

    Researchers say a non-detection in the second and third round of observations with Webb isn’t surprising.

    “We found that in half of the possible orbits simulated, the planet moved too close to the star and wouldn’t have been visible to Webb in both February and April 2025,” said Sanghi.

    Based on the brightness of the planet in the mid-infrared observations and the orbit simulations, researchers say it could be a gas giant approximately the mass of Saturn orbiting Alpha Centauri A in an elliptical path varying between one to two times the distance between the Sun and Earth.

    “If confirmed, the potential planet seen in the Webb image of Alpha Centauri A would mark a new milestone for exoplanet imaging efforts,” Sanghi says. “Of all the directly imaged planets, this would be the closest to its star seen so far. It’s also the most similar in temperature and age to the giant planets in our solar system, and nearest to our home, Earth,” he says. “Its very existence in a system of two closely separated stars would challenge our understanding of how planets form, survive, and evolve in chaotic environments.”

    If confirmed by additional observations, the team’s results could transform the future of exoplanet science.

    “This would become a touchstone object for exoplanet science, with multiple opportunities for detailed characterization by Webb and other observatories,” said Beichman.

    For example, NASA’s Nancy Grace Roman Space Telescope, set to launch by May 2027 and potentially as early as fall 2026, is equipped with dedicated hardware that will test new technologies to observe binary systems like Alpha Centauri in search of other worlds. Roman’s visible light data would complement Webb’s infrared observations, yielding unique insights on the size and reflectivity of the planet.

    More About Webb and MIRI

    The James Webb Space Telescope is the world’s premier space science observatory. Webb is solving mysteries in our solar system, looking beyond to distant worlds around other stars, and probing the mysterious structures and origins of our universe and our place in it. Webb is an international program led by NASA with its partners, ESA (European Space Agency) and CSA (Canadian Space Agency).

    Webb’s MIRI was developed through a 50-50 partnership between NASA and ESA. A division of Caltech in Pasadena, California, JPL led the U.S. contribution to MIRI. JPL also led development of MIRI’s cryocooler, done in collaboration with Northrop Grumman in Redondo Beach, California, and NASA’s Goddard Space Flight Center in Greenbelt, Maryland.

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  • President confers civil, military awards for Marka-e-Haq services – RADIO PAKISTAN

    1. President confers civil, military awards for Marka-e-Haq services  RADIO PAKISTAN
    2. Civil and military leadership, martyrs of Marka-i-Haq honoured with Independence Day awards  Dawn
    3. Pakistan honours civil, military leaders for roles in Marka-e-Haq  The Express Tribune
    4. Field Marshal, PAF chief, PPP chief among others conferred national awards  Geo.tv
    5. PPP Chairman Bilawal to receive prestigious Nishan-e-Pakistan  Daily Times

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  • How Netflix’s new deal with Duke and Duchess of Sussex is ‘different’ from the previous one; yet Meghan Markle says: ‘We’re proud to…’

    How Netflix’s new deal with Duke and Duchess of Sussex is ‘different’ from the previous one; yet Meghan Markle says: ‘We’re proud to…’

    Prince Harry and Meghan Markle have signed a new, less lucrative deal with Netflix. The royal couple’s new deal has transitioned from an exclusive content arrangement to a “first-look” deal. This new agreement gives the US streaming giant the first option to accept or decline new projects from the couple’s production company, Archewell Productions, before other companies can bid. The previous deal, signed in 2020, provided the couple with a significant investment for exclusive content. The shift to a less-binding arrangement suggests the initial high-profile agreement may not have met Netflix‘s expectations. However, this new deal also allows the Duke and Duchess of Sussex more flexibility to work with other platforms.“We’re proud to extend our partnership with Netflix and expand our work together to include the As ever brand,” Markle said in a release.

    Why Netflix changed its previous deal’s terms with Harry and Meghan

    According to a report by the New York Times, Archewell’s original deal aimed to produce a wide range of content, including children’s TV, feature films, and scripted shows, but so far it has focused only on documentaries and docuseries. Its biggest hit, Harry & Meghan (2022), drew 23.4 million views in four days, the most ever for a Netflix documentary. Other projects — Heart of Invictus, Live to Lead, and Polo — saw smaller audiences.In March, Meghan launched With Love, Meghan, a cooking, gardening, and hosting series that received mixed reviews but surpassed viewership for other cooking shows with 5.3 million views.The show also marked Netflix’s first direct partnership with a talent’s consumer brand, promoting Meghan’s “As Ever” line of products like $28 honey and $14 apricot spread, with Netflix co-producing some items and sharing in sales revenue.However, in a statement to the NYT, Bela Bajaria, Netflix’s chief content officer, said: “The response to their work speaks for itself. Fans have been inspired by ‘With Love, Meghan’, with products from the new ‘As ever’ line consistently selling out in record time.”Netflix has shifted away from broad, multi-year talent deals and now favours selective partnerships, the report adds. While some earlier signings like Shonda Rhimes and Adam Sandler thrived, others underperformed. Higher Ground, Barack and Michelle Obama’s company, moved from a complete overhead deal to a first-look agreement after producing hits like American Factory and Leave the World Behind.Meanwhile, relations with Archewell may have reportedly faced challenges, including Netflix learning about Prince Harry’s memoir Spare shortly before releasing the Harry & Meghan docuseries, which covered similar topics — though both sides deny tension. Archewell’s output has primarily centred on the couple, with few other projects advancing. Its family series Pearl was cancelled, a film project based on Let’s Meet at the Lake remains in early stages, and a new short, Masaka Kids, A Rhythm Within, was just announced. A With Love, Meghan Christmas special and season two are also on the way.

    Goodbye, Frequent FASTag Recharges! NHAI Launches Annual Pass for Rs 3,000


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  • Pakistan officers, soldiers awarded for showing bravery during Operation Bunyan-un-Marsoos

    Pakistan officers, soldiers awarded for showing bravery during Operation Bunyan-un-Marsoos

    RAWALPINDI (Dunya News) – President Asif Ali Zardari on Thursday granted military awards to the officers and soldiers of Pakistan Army, Navy and Air Force for showing bravery during Operation ‘Bunyan-UN-Marsoos’.

    As many as 8 Sitara-i-Jurat, 5 Tamgha-i-Jurat, 24 Sitara-i-Basalat, 45 Tamgha-i-Basalat, 146 Distinction Certificates, 259 COAS Commendation Cards and 1 Tamgha-i-Imtiaz (Military) were granted on the Independence Day.

    Following officers were conferred with Sitara-i-Jurat:

    Wing Commander Bilal Raza, GD (P), Air Force, Wing Commander Hammad Ibne Masood, GD (P), Air Force, Squadron Leader M Yousaf Khan, GD (P), Air Force, Squadron Leader Muhammad Osama Ishfaq, GD (P), Air Force, Squadron Leader Muhammad Hassan Anees, GD (P), Air Force, Squadron Leader Talal Hassan, GD (P), Air Force, Squadron Leader Fida Muhammad Khan, GD (P), Air Force, and Flight Lieutenant Muhammad Ashhad Amir, GD (P), Air Force.

    Tamgha-i-Jurat:

    L/Hav Amir Sheraz (Shaheed), Baloch, Nk Abdul Rehman (Shaheed), SSG, L/Nk Ikram Ullah (Shaheed), AK, Sep Adeel Akbar (Shaheed), Punjab, and Capt Ali Hassan, FF.

    Top civil, military leaders honoured at Presidential Awards Ceremony

    Sitara-i-Basalat:

    Sep Nisar Ali (Shaheed), PR (Pb), Lt Gen Muhammad Asim Malik, HI (M), Baloch, Lt Gen Nauman Zakria, HI (M), SI, AC, Lt Gen Muhammad Zafar Iqbal, HI (M), AD, Lt Gen Syed Aamer Raza, HI (M), AC, Lt Gen Shahid Imtiaz, HI (M), AK, Lt Gen Ahmed Sharif Chaudhry, HI (M) EME, Maj Gen Wajid Aziz, HI (M), Punjab, Maj Gen Kashif Abdullah, Punjab, Maj Gen Syed Muhammad Jawad Tariq, FF, Maj Gen Tajdeed Mumtaz, Baloch, Capt Muhammad Haider Ali, Arty, Vice Admiral Raja Rab Nawaz, HI (M), Navy, Rear Admiral Abdul Munib, HI (M), Navy, Rear Admiral Faisal Amin, HI (M), Navy, Rear Admiral Shahzad Hamid HI (M), TBt, Navy, Capt Muhammad Atif Amin, PN, Navy, Air Vice Marshal Muhammad Ehsan Ulhaq, GD (P), Air Force, Air Vice Marshal Aurangzeb Ahmed, GD (P), Air Force, Air Commodore Attaullah Zeb, GD (P), Air Force, Air Commodore Zia Aftab, GD (P), Air Force, Air Commodore Muhammad Noman Ali Khan, GD (P), Air Force, Air Commodore Ali Javed Hashmi, Engg, Air Force, and Air Commodore Sajjad Haider, AD, Air Force.

    Tamgha-i-Basalat:

    Hav Muhammad Naveed (Shaheed), AD, Nk Muhammad Waqar Khalid (Shaheed), Punjab, L/Nk Dilawar Khan (Shaheed), FF, Brig Muhammad Abrar Afzal, CMI, Brig Mubashar Ahmad Abbasi, FF, Brig Affan Ihtasham, AC, Lt Col Zaheer Abbas, AK, Lt Col Muhammad Shahzib Rafi, Arty, Maj Shehryar Sajid, Sigs, Lt Muhammad Bilal Nadeem, Arty, N/Sub Muhammad Imran, FF, Hav Muhammad Faheem, Arty, Hav Muhammad Altaf, FF, Hav Falak Naz, FF, Hav Aamir Iqbal, FF, Hav Rafat Khan, SSG, L/Nk Shaukat Abbas, SSG, Sep Nisar Ahmed, Baloch, Sep Maqsood Ur Rehman, FF, Sep Najam Aziz, AK, Sep Jabir Hussain, Mjd, Commodore Rao Ahmed Imran Anwar, SI (M), Navy, Squadron Leader Usman Yousaf, (Shaheed) Engg, Air Force, Air Commodore Adeel Shahab Qureshi, GD (P), Air Force, Air Commodore Farhan Zia, GD (P), Air Force, Air Commodore Jehanzeb Burki, Engg, Air Force, Air Commodore Azhar Hasan, Engg, Air Force, Air Commodore Rana Ilyas Hassan, AD, Air Force, Air Commodore Syed Muhammad Kamran Abid, AD, Air Force, Group Captian Muhammad Salman, AD, Air Force, Wing Commander Wajeeh Ullah Mian, GD (P), Air Force, Wing Commander Muhammad Shafaat Saeed, GD (P), Air Force, Wing Commander Malik Rizwan-Ul-Haq Iftikhar, GD (P), Air Force, Wing Commander Haider Ijaz, GD (P), Air Force, Wing Commander Junaid Azam, GD (P), Air Force, Wing Commander Awais Nazir, GD (P), Air Force, Squadron Leader Jibran Rashid, GD (P), Air Force, Squadron Leader Kashif Bashir, GD (P), Air Force, Squadron Leader Hassaan Khan, GD (P), Air Force, Squadron Leader Muhammad Zeeshan, GD (P), Air Force, Squadron Leader Muhammad Saad, GD (P), Air Force, Squadron Leader Saad Arif, Engg, Air Force, Squadron Leader Aamir Ghafoor, AD, Air Force, Squadron Leader Muhammad Arqam Raees, AD, Air Force and Flight Lieutenant Muhammad Nouman Shafique, GD (P).

    Distinction Certificates:

    Maj Gen Muhammad Irfan, HI (M), Punjab, Maj Gen Ch Amir Ajmal, HI (M), Baloch, Maj Gen Mushtaq Ali, HI (M), Arty, Maj Gen Salmaan Moin, HI (M), Baloch, Maj Gen Muhammad Abbas, Arty, Maj Gen Shahid Amir Afsar, Punjab, Maj Gen Muhammad Imran Khan Babar, Sindh, Maj Gen Usman Iqbal, Arty, Maj Gen Muhammad Intikhab Alam, Brig Sajjad Sarwar, Sigs, Brig Ghazanfar Iqbal, Arty, Brig Muhammad Arshad, FF, Brig Waqar Ali, Arty, Brig Ahson Mansoor Virk, Pubjab, Lt Col Ahmed Umar, AC, Lt Col Muhammad Shahzad, Arty, Lt Col Waqas Mansoor, Arty, Lt Col Muhammad Zakriya, EME, Lt Col Ansar Chand, FF, Lt Col Shahbaz Ali Khan, FF, Lt Col Ali Zeshan, AK, Lt Col Ahmad Ali, CMI, Maj Muhammad Ammad, ICTO, Maj Farhat Ali, Arty, Maj Najeeb Ur Rehman, Sigs, Maj Naveed Ullah, Arty, Capt Muhammad Fahad Zaheer, AD, Capt Muhammad Taqveem Khalid Gill, Arty, Capt Yasir Jamil, FF, Capt Badar Khan Riaz, Arty, Capt Muhammad Ahmad, Arty, Capt Arham Didar, AD, Capt Muhammad Wajahat Younas, AMC GDMO, Lt Anas Naeem, Arty, Lt Noushair Zaman Cheema, NLI, 2/Lt Mazhar Ali, Mjd, Sub Muhammad Javed, FF, Sub Rahmat Ullah, Mjd, N/Sub Muhammad Akil, Arty, Hav Asad Ali Khan, Arty, Hav Imam Ali, Baloch, Hav Sadullah Shah, FF, Hav Muneer Ahmad, Mjd, Hav Mujeeb Ur Rehman, Mjd, L/Hav Mujahid Azam, AD, L/Hav Inayat Aziz, Mjd, Nk Muhammad Minahal, AD, Nk Sohail Iqbal, PR (Pb), L/Nk Ahsan Ali, AD, L/Nk Muhammad Rasheed, Baloch, L/Nk Muhammad Jaffar Khan, FF, L/Nk Dil Fraz Hussain, AK, Sep Asif Ali, Arty, Sep Sharafat Ullah, AK, Sep Zahid Hussain, NLI, Sep Muhammad Asif, Mjd, Sep Khubaib Hussain, Mjd, Sep Abdul Sattar, PR (Pb), Commodore Ahmed Hussain SI (M), Navy, Commodore Anwar Saeed TI (M), Navy, Captain Syed Ijaz Hussain Shah PN, Navy, Captain Muhammad Ali PN, Navy, Captain Sohail Ahmed Raja PN, Navy, Captain Kamran Ali Bhatti PN, Navy, Lt Waleed Arshad PN, Navy, CWEA (OC) Muhammad Ijaz, Navy, Air Commodore Syed Nabeel Masood GD (P), Air Force, Air Commodore Irfan Rasul Ghauri GD (P), Air Force, Air Commodore Abdul Ghaffar Buzdar GD (P), Air Force, Air Commodore Mudassar Arshad Malhi GD (P), Air Force, Group Captain Muhammad Saleem Raza GD (P), Air Force, Group Captain Muhammad Jawad Azim GD (P), Air Force, Group Captain Zeeshan Ali GD (P), Air Force, Group Captain Ameer Hamza Mehdi GD (P), Air Force, Group Captain Farhan Ahmed GD (P), Air Force, Group Captain Umair Ali AD, Air Force, Wing Commander Qasim Khan GD (P), Air Force, Wing Commander Muhammad Umair Riaz GD (P), Air Force, Wing Commander Muhammad Safyan Azad GD (P), Air Force, Wing Commander Muhammad Waqas Rasheed GD (P), Air Force, Wing Commander Umar Farooq GD (P), Air Force, Wing Commander Muhammad Faisal Engg, Air Force, Wing Commander Imran Atif AD, Air Force, Wing Commander Asim Ali Shah Edu, Air Force, Squadron Leader Abdur Rehman GD (P), Air Force, Squadron Leader Zaeem Khalid GD (P), Air Force, Squadron Leader Muslim Raza GD (P), Air Force, Squadron Leader Zeshan Muhammad GD (P), Air Force, Squadron Leader Muhammad Umair Raza GD (P), Air Force, Squadron Leader Shaiq Ashraf GD (P), Air Force, Squadron Leader Muhammad Umar Ahmad GD (P), Air Force, Squadron Leader Makhdoom Muhammad Sami GD (P), Air Force, Squadron Leader Yasir Akram GD (P), Air Force, Squadron Leader Junaid Amjad Siddique GD (P), Air Force, Squadron Leader Mudassar Javed GD (P), Air Force, Squadron Leader Abdur Rehman Khan GD (P), Air Force, Squadron Leader Hassam Hassan GD (P), Air Force, Squadron Leader Abdul Rafay GD (P), Air Force, Squadron Leader Adnan Akram GD (P), Air Force, Squadron Leader Ali Qasim GD (P), Air Force, Squadron Leader M. Muneeb ul Hassan GD (P), Air Force, Squadron Leader Saroosh Haider GD (P), Air Force, Squadron Leader Sikandar Waseem GD (P), Air Force, Squadron Leader Hassam Ashfaq GD (P), Air Force, Squadron Leader Asfandyar Awan Engg, Air Force, Squadron Leader Ammar Hussain Farooqi, Engg, Air Force, Squadron Leader Faizan Ul Haq Rajput Engg, Air Force, Squadron Leader Noman Hydair Engg, Air Force, Squadron Leader Muhammad Abid AD, Air Force, Squadron Leader Sulaman Ishtiaq Satti AD, Air Force, Squadron Leader Junaid Ahmed AD, Air Force, Squadron Leader Atta Ullah Sahibzada AD, Air Force, Squadron Leader Zia Ur Rehman AD, Air Force, Squadron Leader Nadeem Anwer Nadeem A&SD, Air Force, Squadron Leader Muhammad Danish Iqbal A&SD, Air Force, Squadron Leader Majid Shehzad IT, Air Force, Squadron Leader Muhammad Azhar Latif Met, Air Force, Squadron Leader Rizwan Karim MES, Air Force, Flight Lieutenant Muhammad Sarosh Engg, Air Force, Flight Lieutenant Rana Muhammad Hasan Engg, Air Force, Flight Lieutenant Muhammad Usman Engg, Air Force, Flight Lieutenant Muhammad Zarar Hashmi Engg, Air Force, Flight Lieutenant Muhammad Yahya Haider A&SD, Air Force, Flight Lieutenant Usama Khalid A&SD, Air Force, Flying Officer Tabassum Hussain Engg, Air Force, Flying Officer Muhammad Hassaan Nasir Engg, Air Force, CWO Ikram Khan, Air Force, CWO M Ashraf Khan, Air Force, CWO Muhammad Majid, Air Force, CWO Shahid Kamran Khan, Air Force, WO Muhammad Azam, Air Force, AWO Muhammad Adnan, Air Force, Chf Tech Sami Ullah, Air Force, Chf Tech Muhammad Aurangzeb, Air Force, Chf Tech Samander Khan, Air Force, Chf Tech Muhammad Aleem, Air Force, Chf Tech Muhammad Ashraf, Air Force, Snr Tech Muhammad Ayaz, Air Force, Snr Tech Mubashir Javed, Air Force, Snr Tech Najeeb Sultan, Air Force, Snr Tech Waseem, Air Force, Snr Tech Arshad Mobeen, Air Force, Snr Tech Asghar Ali, Air Force, Snr Tech Ihsan Ullah, Air Force, Snr Tech Muhammad Imran, Air Force and Cpl Tech Farooq Ahmad, Air Force.

    COAS Commendation Card

    Maj Gen Rana Arfan Shakeel Ramay, SI, CMI, Maj Gen Syed Ali Raza, HI (M), Sigs, Brig Muhammad Tariq Khan, Baloch, Brig Muhammad Sajid Mahmood, Baloch, Brig Muhammad Mehraj Khan, AD, Brig Aamir Fareed Khan, FF, Brig Zaka Ullah, Arty, Brig Jawad Haider, Arty, Brig Syed Talal Mansoor, Punjab, Brig Salis Ahmed, Sigs, Brig Asad Rauf, Sigs, Brig Farhan Shahid Khan, Sigs, Brig Ali Nawaz Khan Niazi, AC, Brig Hariss Aziz Ansari, Sigs, Brig Nauman Rashid Khan, Sigs, Col Usman Khalid, AD, Col Shahid Mehmood Akhtar, Engrs, Col Noman Rehman Khattak, CMI, Col Khaqan Sarwar, Sigs, Col Nabeel Asghar, EME, Lt Col Syed Muhammad Tahir Hameed, CMI, Lt Col Usama Khan, AC, Lt Col Muhammad Afzal Riaz, Arty, Lt Col Khuldoon Bin Nazeer, CMI, Lt Col Muhammad Mehdi, Baloch, Lt Col Adnan Ahmad Khan, AK, Lt Col Bilal Shahzad, CMI, Lt Col Muhammad Shahzad Khurshid, AC, Lt Col Syed Ahmed Raza Kazmi, Arty, Lt Col Muhammad Bilal, Punjab, Lt Col Muhammad Imran, Punjab, Lt Col Muhammad Yousaf, Baloch, Lt Col Mirza Jahantab Khalid, Arty, Lt Col Abubakar Murtaza Buttar, Punjab, Lt Col Muhammad Rizwan Younas, Sigs, Lt Col Muhammad Wasif Zia, Arty, Lt Col Shahid Hussain, Arty, Lt Col Muhammad Ali Nawaz, Arty, Lt Col Muhammad Qamber Raza, GL, Lt Col Noman Khalil, Baloch, Lt Col Umair Aziz Bhatti, Sindh, Lt Col Aqeel Zahid, Sindh, Lt Col Aamir Shoaib Akhtar, Sigs, Lt Col Hamza Nawaz Khan, FF, Lt Col Muhammad Asad Khan, AK, Maj Aamir Irshad, Engrs, Maj Irfan Haider, AK, Maj Tahir Iqbal Khattak, Arty, Maj Muhammad Umer Javed, TSO, Maj Farhan Akbar, Baloch, Maj Mushaf Bin Ali, Arty, Maj Muhammad Umair Saeed, Arty, Maj Abdullah Kamran, FF, Maj Abdul Muqtadir Khan, Sindh, Maj Shahzeb Ibne Ahmad, CMI, Maj Muhammad Akhtar, Arty, Maj Muhammad Ahmer, Arty, Maj Muhammad Akash Arshad, CMI, Maj Imran Khan, Baloch, Maj Faizan Ahmed, AK, Maj Tasawar Abbas, CMI, Maj Mamoon Elahi Malik, Arty, Maj Abdul Qadir, Sigs, Maj Daniyal Riaz Siddiqui, Arty, Maj Muhammad Hasan Khan, Arty, Maj Muhammad Ali Zia, AD, Maj Muhammad Shaheryar Saleem, Arty, Maj Muhammad Saad Arshad, Arty, Maj Ali Raza, AD, Maj Muhammad Taimoor Malik, Punjab, Maj Syed Osama Hussain Bokhari, Sigs, Maj Osama Naeem Khan, EME, Maj Ghulam Mustafa, NLI, Maj Faheem Abbas, ICTO, Maj Muhammad Zubair, Arty, Maj Hassan bin Faiz, Sigs, Maj Muhammad Adnan, Mjd, Maj Kamran Salim, Mjd, Maj Ali Raza, Mjd, Maj Zulfiqar Ali, Mjd, Maj Rana Waseem Akbar, Mjd, Maj Muhammad Fahad Iqbal, Mjd, Maj Khalid Yaqoob, Mjd, Capt Abdullah, Punjab, Capt Muneeb Jamal Aamir, Arty, Capt Muhammad Usama, Punjab, Capt Muhammad Mahad Aamir, Arty, Capt Umair Hassan, Arty, Capt Basit Ali, Arty, Capt Zain Zaman, Arty, Capt Bilal Ahmed Gil, AD, Capt Umair Fayyaz Khan, Arty, Capt Muhammad Anas Bin Ateeq, AK, Capt Tameem Ali Khan, FF, Capt Umer Waqas, Arty, Capt Mehrab Israr, Atry, Capt Awais Ur Rehman, Arty, Capt Kaleem Ullah, AMC GDMO, Capt Mahnoor Nasar, Sigs, Capt Muhammad Haider Ijaz, Mjd, Lt Imran Kashif, AK, Lt Haseeb Ali, Arty, Lt Arbaz Khan Khalji, Arty, Lt Waqas Ali, Arty, Lt Muhammad Awais Yassen, Arty, Lt Muhammad Huzaifa Altaf, Arty, Lt Abdullah Bin Masood, Punjab, Lt Zohaib Yameen, FF, Lt Zeeshan Imtiaz, AD, Lt Mujtaba Ahmed, Baloch, Lt Saifullah Shah, Sindh, Lt Huzaifa Ikram, Arty, Lt Waqar Aslam, Mjd, Lt Muhammad Shamshad, Mjd, Sub Muhammad Munir, Arty, Sub Zafar Iqbal, Arty, Sub Zafar Iqbal, Sigs, Sub Sadaqat Hayat, Sigs, Sub Ghulam Hassan, EME, Sub Fiaz Muhammad, EME, Sub Muhammad Soomar Mal, EME, Sub Muhammad Sadiq, Mjd, Sub Muhammad Saleem, Mjd, Sub Karim Shah, Mjd, N/Ris Sajjad Ahmed, AC, N/Ris Ashfaq Ahmed, Arty, N/Sub Fiaz Ahmed, Sigs, N/Sub Munir Ahmed, Sigs, N/Sub Ishfaq Ahmed, Baloch, N/Sub Rafaqat Ali, Baloch, N/Sub Hamid Ali, FF, N/Sub Javed Iqbal, AK, N/Sub Jamil Mir, Mjd, N/Sub Ishtiaq Aziz, Mjd, N/Sub Iftikhar Hussain, Mjd, N/Sub Ansar Baig, Mjd, Hav Janat Gul, Arty, Hav Feroz Khan, Arty, Hav Saqib Ijaz, Arty, Hav Imran Khan, Arty, Hav Muhammad Hasniain Haider, Arty, Hav Muhammad Tanveer, Arty, Hav Arab Hussain, Arty, Hav Muhammad Shoaib, Arty, Hav Khalid Mehmood, AD, Hav Abdul Rehman, AD, Hav Muhammad Waqar, AD, Hav Muhammad Saeed Awan, AD, Hav Muhammad Anwar, AD, Hav Haq Nawaz Bashir, AD, Hav Usman Rasheed, AD, Hav Qasir Mehmood, Sigs, Hav Hameed Ahmed, Sigs, Hav Fazal-i-Khuda, Sigs, Hav Muhammad Waqas, Baloch, Hav Muhammad Fayyaz, FF, Hav Abdul Haleem, FF, Hav Abid Ali, FF, Hav Asrar Hussain, AK, Hav Haji Khan, Ord, Hav Muhammad Pervaiz, CMI, Hav Muhammad Iqbal, CMI, Hav Fasial Mehmood, Mjd, Hav Sher Afzal, Mjd, Hav Muhammad Shebaz, Mjd, Hav Muhammad Saddique, Mjd, Hav Zubair Ahmed, Mjd, Hav Hassnain Raza, Mjd, Hav Mirzad Khan, Mjd, L/Hav Rafi Ullah, AD, L/Hav Muhammd Shafique, AD, L/Hav Faisal Mehmood, Sigs, L/Hav Zahid Hussain, NLI, L/Hav Muhammad Shahbaz, Kiani, Mjd, Nk Muhammad Faraz Nazir, Arty, Nk Sher Afzal, Arty, Nk Mustansar Hussain, Arty, Nk Muhammad Umer Faroque, Arty, Nk Asghar Ali, Arty, Nk Tariq Aziz, Arty, Nk Qamar Zaman Haider, Arty, Nk Muhammad Ayoub, AD, Nk Muhammad Naveed, AD, Nk Muhammad Waris, Engrs, Nk Rao Kamran Ali, Sindh, Nk Ehsan Akhtar, Sigs, Nk Mumtaz Khan, Punjab, Nk Muhammad Azam, AK, Nk Muhammad Riqwan, AK, Nk Muhammad Idrees, AK, Nk Ali Muhammd, EME, Nk Noor Hassn, EME, Nk Muhammad Usman, CMI, Nk Ubaid Nazir, Mjd, Nk Zubair Hussain Khan, Mjd, Nk Iqbal Hussain, Mjd, Nk Parvaiz Ahmed, Mjd, Nk Syed Abrar Hussain Shah, Mjd, Nk Amir Shahzad, Mjd, Nk Shehbaz Akhtar, Mjd, L/Nk Hasnain, Arty, L/Nk Saddam Hussain, AD, L/Nk Muhammad Ghafoor, AD, L/Nk Shoaib Khan, Punjab, L/Nk Shamsud Din, AK, L/Nk Kashif Hussain, Sindh, L/Nk Irfan Abbas, Sindh, L/Nk Ahsan Ullah, NLI, L/Nk Muhammad Hassan, SSG, L/Nk Waqar, SSG, L/Nk Muhammad Mehboob, Mjd, L/Nk Muhammad Idrees Khan, Mjd, L/Nk Javeed Iqbal, Mjd, Sep Nadeem Abbas, Arty, Sep Munawar Iqbal, AD, Sep Muhammad Amjad, AD, Sep Dur Muhammad, Spr Amjad Gul, Engrs, Sep Yashar Khayyam, Sigs, Sep Saeed Alam, Punjab, Sep Muhammad Bilal, Punjab, Sep Pervaiz Hussain, Punjab, Sep Mirza Adeel Asif Baig, Punjab, Sep Ali Imran, Punjab, Sep Waseem Ahmed, Punjab, Sep Muhammad Asif, Baloch, Sep Ibrar Ali, FF, Sep Sadiq Rehman, FF, Sep Haider Ali, FF, Sep Asif Ali, FF, Sep Muhammad Rashid, FF, Sep Zeeshan, FF, Sep Muhammad Sharif, FF, Sep Shahid Rashid, AK, Sep Muhammad Wasif, Ak, Sep Umer Nazir, Ak, Sep Nawaz Khan, NLI, Sep Waseem Sajjad, NLI, Sep Muhammad Arslan Shehzad, SSG, Sep Rawal Aslam, SSG, Sep Muhammad Waseem, SSG, Sep/ NA Syed Touqeer Hussain Shah, AMC, Sep/ NA Muhammad Waqas, AMC, Sep/ NA Muhammad Shahzeb, AMC, Sep/ NA Jamil Aziz, AMC, Sep/ NA Adeel Tariq, AMC, Sep/ NA Muhammad Umer Farooq, AMC, Sep Muhammad Maqbool, Mjd, Sep Niazullah, Mjd, Sep Adnan Manzoor, Mjd, Sep Sabeel Iqbal, Mjd, Sep Asad Shaheen, Mjd, Sep Muhammad Kashif, Mjd, Sep Adnan Noor, Mjd, Sep Adeel Ahmed Kiani, Mjd, Sep Muhammad Faisal, Mjd, DSR Mehrab Gul, Pakistan Rangers (Pb), Sep Ghulam Mustafa, Pakistan Rangers (Pb), Sep Muhammad Usman, Pakistan Rangers (Pb),

    Tamgha-i-Imtiaz (Military):

    Lieutenant Commander Khurram Riaz, Navy.


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  • Frailty raises the risk of lung attacks and death in smokers

    Frailty raises the risk of lung attacks and death in smokers

    A new research paper was published in Volume 17, Issue 7, of Aging (Aging-US) on July 3, 2025, titled “Frailty associates with respiratory exacerbations and mortality in the COPDGene cohort.”

    In this study, led by first author Eleanor Kate Phillips from Brigham and Women’s Hospital and corresponding author Dawn L. DeMeo from Brigham and Women’s Hospital and Harvard Medical School, researchers investigated how frailty impacts lung health and survival in individuals with a history of cigarette smoking. They found that frailty raises the risk of lung attacks and death, even in smokers with preserved lung function. This result shows why all current and former smokers should be checked for frailty.

    Frailty is a condition that makes the body more vulnerable to illness, especially in older adults. This study focused on more than 2,600 adults with a history of heavy smoking, many of whom showed no signs of lung damage on standard tests. At the second follow-up visit, participants were categorized as robust, prefrail, or frail and followed for about three years. Researchers tracked how often they experienced respiratory attacks, such as episodes of severe coughing or breathlessness, and whether they survived during that period.

    “COPDGene is a cohort study of individuals aged 45–80 with a minimum 10 pack-year smoking history.”

    The results showed that people who were frail had a three- to five-fold higher chance of developing serious or frequent respiratory attacks compared to those who were robust. These risks were not limited to people with chronic lung disease. In fact, many frail participants with normal lung function still faced a significantly higher chance of lung attacks and death. Even those in the “prefrail” stage, a milder form of frailty, were more likely to experience health complications.

    The research team also found that frailty was associated with an accelerated pace of biological aging, measured using a DNA-based test called DunedinPACE. This supports the idea that frailty may reflect deeper biological changes in the body that go beyond what traditional lung function tests can detect. These findings challenge the idea that standard lung tests can rule out future respiratory complications in people with a history of smoking. 

    Altogether, the study shows that simple frailty checks could help identify early health problems, allowing for timely interventions that may prevent hospitalizations and potentially save lives. The study suggests that frailty screening may be a valuable tool in public health efforts to reduce respiratory disease and improve outcomes for aging adults.

    Source:

    Journal reference:

    Phillips, E. K., et al. (2025). Frailty associates with respiratory exacerbations and mortality in the COPDGene cohort. Aging. doi.org/10.18632/aging.206275.

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