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  • In ‘Ballard,’ Maggie Q brings the heat to cold cases

    In ‘Ballard,’ Maggie Q brings the heat to cold cases

    Landing a lead role in a TV series would seem like a dream scenario for an up-and-coming actor. But it can also become a nightmare. Just ask Maggie Q.

    The actor, who got her start in Hong Kong action films, scored the title role in the CW’s 2010 spy thriller “Nikita,” where she was able to showcase her athletic prowess while becoming one of the few Asian actors to star in a network drama series.

    Although Q was grateful for the experience, she also remembers the project as all-consuming and grueling, prompting her to be more selective about her choices.

    Her inner red flag went up when she was first approached about starring in “Ballard,” Prime Video’s new show based on a series of best-selling novels about fictional LAPD detective Renée Ballard by former Los Angeles Times journalist-turned-author Michael Connelly.

    “I get a lot of scripts, and a lot of them I don’t like,” said Q, whose real name is Margaret Denise Quigley. “I also wasn’t looking to take on another show. It was like, ‘Is this something I really want to do right now?’ I know what it takes to be No. 1 on a show. It’s a massive output, and it really has to be good enough for me to want to do that again.”

    To her surprise, she loved the scripts. After meeting with Connelly and other producers, she said, “I knew I was in a room with people I wouldn’t mind spending years of my life with.”

    Maggie Q wasn’t looking to work on another TV show, but after reading the scripts and meeting with Michael Connelly, she changed her mind.

    (Tyler Golden / Prime Video)

    Q is now back at the No. 1 slot on the call sheet in “Ballard,” premiering Wednesday with 10 episodes. The new TV series is a spinoff of “Bosch: Legacy,” which wrapped its third and final season in March.

    Ballard first appeared in Connelly’s 2017 book “The Late Show,” and she has continued to solve crimes in five other novels. The detective joins quirky attorney Mickey Haller (known as the “Lincoln Lawyer”) and world-weary police detective Hieronymus “Harry” Bosch in the gallery of Connelly’s colorful characters to jump from the bestseller list to the TV screen.

    Q felt an instant admiration for Ballard’s dedication to her job as well as her strong personality, which often puts her at odds with her male colleagues. She was also impressed that the character was inspired by real-life investigator Mitzi Roberts, who worked in LAPD’s elite Robbery-Homicide unit.

    In the series, the investigator has been newly demoted from Robbery-Homicide after clashing with her male partner and has been reassigned to head up the underfunded cold case unit, supervising a staff of reserves and volunteers. Titus Welliver, who played Bosch in the eponymous series and in “Legacy,” will appear periodically during the season.

    Connelly has been a longtime fan of Q, whose more prominent roles include the only female member of the Impossible Mission Force headed by Tom Cruise’s Ethan Hunt in “Mission Impossible III” and a dogged FBI agent in ABC’s “Designated Survivor.”

    “She has a relentless aura about her,” said Connelly in a phone interview. He was also thrilled that Q and Roberts share similarities: “They both have a confidence and a fierceness in their eyes. They have matching histories — they both grew up in Hawaii and they surf. It’s like it was fated to be.”

    A woman in a dark police uniform salutes a passing coffin draped in an American flag.

    Michael Connelly based Renée Ballard on LAPD investigator Mitzi Roberts. “They both have a confidence and a fierceness in their eyes,” he said.

    (Tyler Golden / Prime Video)

    “Ballard” is a sharp reversal from Q’s last series — the 2024 Fox comedy “Pivoting,” about three close-knit women who are trying to cope with the death of another friend. Q played a doctor who decides to make a life change and work in a grocery store. The show only lasted one season.

    In a separate interview, Roberts, who is a consulting producer on the new show, said Q was her first choice among the actors being considered to play Ballard.

    “She has played so many realistic, strong female characters,” she said. “When Maggie got the part, I was ecstatic. When we first met to have coffee, it was like we’ve known each other our whole lives. During several days of physical training before production, I thought there might be things that would be hard for her to work on. But it was never an issue. She approached everything so professionally.”

    During a video interview from her home in Hawaii, Q discussed the new series, her raw memories of “Nikita” and why she doesn’t go to Hollywood parties. The interview has been edited for length and clarity.

    Were you familiar with Michael Connelly or his books before you became involved with the show?

    My first exposure were those first six or seven scripts, which I read on a plane to New Zealand. I was aware of Michael Connelly, but only peripherally. I’m an avid reader and I wish I had more time to read fiction, but I don’t. So I wasn’t schooled on Mike’s massive success. After I read the scripts and liked them, I then dove into who Michael was and found it really interesting that he parlayed being a journalist into this wildly successful fiction career.

    How important was it when you learned that Renée was based on a real detective?

    When I finally met Mitzi, we got on in a way that was very unpredictable. She felt like a sister. She ended her career in cold cases, and it was there that she was really able to connect the DNA in crimes that were completely unrelated.

    Although you’ve done so many kinds of projects, this still strikes me as an unlikely Maggie Q vehicle.

    I agree. I have to feel something; there has to be an emotion that resonates down the line. I need to feel longevity with it. A lot of consultants working on this show were or are people who are retired. I can see and feel in their stories and the lives they live now that they still haven’t let go of cases they were not able to close. The peace they haven’t been able to bring to a certain family still bothers them. The quality of these people is extraordinary. I felt it was an honor to tell their stories.

    Harry Bosch and the Lincoln Lawyer are very dynamic. Renée is a lot more reserved and closed off. She does not connect easily with others. Was that a challenge to make her feel alive?

    In terms of Renée, being in Robbery-Homicide was her dream job. She wanted to get the bad guys. To be demoted the way that she was — there’s a certain amount of bottling up that comes with that. She then has to prove herself in a department that she doesn’t want to be in and never asked for. In doing that, maybe they will again see in her the detective that she was and bring her back to the job she loved so much.

    A man holds out a hand toward a woman in a dark suit and white shirt stained with blood.

    “In terms of Renée, being in Robbery-Homicide was her dream job. She wanted to get the bad guys. To be demoted the way that she was — there’s a certain amount of bottling up that comes with that,” Maggie Q said on her character.

    (Greg Gayne / Prime Video)

    This show is a sharp pivot from your last TV series, “Pivoting.” It was jarring to see you in a comedy.

    That show was a dream job. It was a huge departure for me, and that was what was fun about it. Nobody expected me in that role. It was a gift to me. The show did not perform like we hoped. Fox offered to save the series by moving it to another country, and I was not willing to do that.

    I’m very curious about your ordeal with “Nikita.” You once described it as an experience that almost killed you.

    It really did. Up to that point, I had done only films. I had never done a TV show, and I was very naive. I remember going into it with positive energy. David Solomon, one of the producers in the first season, took me to lunch. He had been on “Buffy the Vampire Slayer” for seven years and watched how Sarah Michelle Gellar killed herself being the title character. “Maggie,” he said, “do you know what it will take to lead this show?” I said, “No, but I work really hard.” He said, “I appreciate that, but can you even conceptualize the output you will need on this show? I watched Sarah Michelle suffer for seven years. Everything was on her shoulders.”

    I have never been so wrong about what it would take to do a show like that. I’m pretty optimistic, but nothing in my bag of tricks was working when I was on that show. It’s not just about the job. You have to deal with people’s personalities, writers, schedules. And I was in Canada on my own, with no support, leading a show that I thought I would be able to sustain for 10 months during the year because of my work ethic. I have never been so wrong. Because I had done action movies, there was a level I wanted to reach that people had never seen before. I was doing my own stunts, working with choreographers at the top of their game. I’m really proud of the level of action we did bring to the small screen.

    People may find it surprising that you live in Hawaii. I know you were born and raised there.

    My husband and I live in a couple of different places, but we spend a lot of time here because there is peace here. There’s no traffic, it’s low crime, the air is clean. For a lot of Hollywood actors, they do the work and then want to get as far away from the industry as possible. I work in the industry but have never immersed myself in it. I don’t go to parties; I don’t hang out. I do my job and go home, and that’s the way I like it. I never thought being seen had any real value. I just want to be at home, be with my dogs and be in nature. That’s what grounds me. Then when I’m back in Hollywood and on the clock, I have a peace that no one can take away.

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  • HBO Max is back. Prestige brand returns to streaming

    HBO Max is back. Prestige brand returns to streaming

    Who says you can’t go Home Box Office again?

    Warner Bros. Discovery renamed its streaming service HBO Max on Wednesday, formally reversing its decision from two years ago to dump the prestigious HBO brand in a bid to make the service more appealing to a mainstream, meat-and-potatoes crowd.

    The gambit to chase Netflix with a service called Max didn’t work. Warner Bros. Discovery’s leaders eventually recognized the tremendous value in the HBO name, and sheepishly brought it back for an encore.

    The company announced the switch in May.

    “The good news is I have a drawer full of stationary from the last time around,” HBO Chairman Casey Bloys said in May, making light of Warner Bros. Discovery’s about-face during the company’s annual programming upfront presentation to advertisers at Madison Square Garden in New York.

    The move marks the fifth name for the service in 15 years.

    HBO’s first digital offering, introduced in 2010, was called HBO Go. Eventually the company added an HBO Now app. Then, in 2020, when the company launched its comprehensive streaming service with Warner Bros. movies and television shows, executives decided the HBO Max name would play to the company’s strengths while beckoning customers with a souped-up product and moniker to match.

    That lasted until Chief Executive David Zaslav stepped in. The company truncated the name to Max because Zaslav and other executives felt the need to create some distance from HBO’s signature shows to make room for the nonscripted fare of Discovery’s channels, including HGTV and Food Network.

    Now it’s back to HBO Max.

    The company has said the shift was a response to audiences’ desire for quality over quantity.

    “No consumer today is saying they want more content, but most consumers are saying they want better content,” the company said in May.

    The change also represents a recognition that Warner Bros. Discovery, a medium-sized media company with a huge debt burden, couldn’t compete with Netflix, which tries to offer something for everyone.

    And while some of the Max-branded shows, including “The Pitt,” are critically acclaimed, it was the HBO fare, including “The White Lotus,” that has been the most consistent draw for subscribers.

    HBO built its legacy as a premium cable channel that required an additional fee on the monthly cable bill. Such groundbreaking series as “The Sopranos,” “Game of Thrones” and “Sex and the City” put the channel at the vanguard of prestige programming.

    Most subscribers who currently have Max won’t need to download a new app, company insiders said.

    An app update will eventually change the blue Max logo to a black HBO Max one.

    Staff writer Stephen Battaglio contributed to this report.

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  • How GLP-1 Drugs Could Cause Vision Loss in Diabetics

    How GLP-1 Drugs Could Cause Vision Loss in Diabetics

    Hi, it’s Michelle in New York. You may have heard of “Ozempic blindness,” when obesity drugs are linked to rare vision loss. Does this discovery change the risk-benefit analysis for the drugs? More in a moment, but first …

    In June, EU regulators said that people with type 2 diabetes taking semaglutide, the active ingredient in Novo Nordisk’s Ozempic and Wegovy, are at risk of developing a rare eye condition that can cause vision loss. This could possibly affect as many as 1 in 10,000 people taking the medicine.

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  • High-class junior football – top European teams to compete at Porsche Football Cup

    High-class junior football – top European teams to compete at Porsche Football Cup




    The 2025 Porsche Football Cup will once again be held at VfB Stuttgart on 6 and 7 September. An international field will be competing for the title at one of the premier U-15 tournaments in Europe. Awaiting the eight teams is a wide range of side events over the tournament weekend. The focus is also on the social aspect of the Porsche Youth Development Programme. Through the “Goals for Charity“ fundraiser, Porsche will donate 400 euro for every goal to the “Stiftung OlympiaNachwuchs” foundation


    The U-15 football tournament has established itself as one of the most renowned junior competitions in Europe ever since its inception in 2021. “Through the Porsche Youth Development Programme, we want to fulfil big dreams and foster young athletes both in their sporting and personal development. As one of the most attractive junior football tournaments in Europe, it has been vital in doing just that in the last five years and perfectly reflects the idea behind the Porsche Youth Development Programme,” says Dr. Jochen Breckner, Member of the Executive Board for Finance and IT at Porsche AG.

    A factor for the success of the Porsche Football Cup is the top names amongst the competing clubs. In addition to FC Barcelona, FC Bayern Munich and VfL Wolfsburg, partner clubs of the Porsche “Turbo für Talents” Youth Development Programme – hosts VfB Stuttgart, Red Bull Football Academy Salzburg, Borussia Mönchengladbach, FC Erzgebirge Aue and SV Stuttgarter Kickers – will also be playing for the coveted trophy.

    FC Barcelona, FC Bayern, Porsche Fußball Cup, 2024, Porsche AG




    Porsche Football Cup at VfB Stuttgart: FC Barcelona vs. FC Bayern

    “The Porsche Football Cup is a fantastic tournament, both on and off the pitch. It’s also famous far beyond Stuttgart’s borders. We’re looking forward to watching top European teams like Barcelona, the title holders,” says Dr. Sebastian Rudolph, Vice President Communications, Sustainability and Politics. “Alongside the competitive side of things, the focus is on the social aspects. We help give the athletes an understanding of values, further a sense of togetherness and bolster social awareness.”

    The programme at a glance

    On Friday, 5 September, the teams will have the chance to get to know each other when the groups are drawn in the Porsche Museum – and to immerse themselves in the history of the sports car manufacturer. The tournament will begin on Saturday, 6 September with the preliminary round matches. Split up into two groups of four, the clubs will start with a round robin. Each match will consist of two 20-minute halves.

    Porsche Museum, Porsche Fußball Cup, 2024, Porsche AG





    The top two teams in each group will meet in the semifinals on Sunday morning (7 September). The other results in the group matches will determine who plays each other in the play-offs for the placings. The highlight is the final that will take place at about 1.45 pm in the Robert-Schlienz-Stadium. Admission is free for visitors on both days of the tournament. Awaiting the fans off the pitch are, in addition to the various refreshment stalls, exciting activities for young and old to try their hand at.

    Societal commitment

    The Porsche Football Cup counts, alongside the Porsche Turbo Award and the “Talents Hand in Hand“ activities, is one of the core components of the “Turbo for Talents” initiative. Through the Youth Development Programme, the sports car manufacturer supports young talents in their sporting, personal and social development. The teams will as a result also this year take part during the week of the tournament in a CSR activity as a part of the “Talents Hand in Hand” programme. The young footballers can also contribute to the “Goals for Charity“ fundraiser by scoring lots of goals. Every time the ball hits the back of the net, the sports car manufacturer will donate 400 euro to the “Stiftung OlympiaNachwuchs Baden-Württemberg”.  

    Talents hand in hand campaign with all teams, 2025, Porsche AG




    Talents hand in hand campaign with all teams

    “Sporting and personal development in junior sport is becoming increasingly important. The Porsche Youth Development Programme “Turbo for Talents“ has been pursuing the idea for years now with its excellent holistic approach,” says the former World Cup winner and Porsche Brand Ambassador, Sami Khedira. “The Porsche Football Cup is a real highlight amongst the numerous measures. The programme, the setup and the social aspect are all unique. It’s also something very special for junior teams to compete nationally or even internationally with other top teams. They all gain invaluable experience.”

    “Turbo for Talents” – the Porsche Youth Development Programme

    Porsche takes its societal responsibility seriously and invests specifically in the future of young people via the Porsche Youth Development Programme. Under the motto “Turbo for Talents”, Porsche commits itself to helping youngsters in a variety of sports in several clubs. In football, there are partnerships with SV Stuttgarter Kickers, the Red Bull Football Academy, Borussia Mönchengladbach, VfB Stuttgart and FC Erzgebirge Aue. In the sport of ice-hockey, Porsche helps foster juniors at the Bietigheim Steelers club. In basketball, Porsche lends its name to the Ludwigsburg Porsche Basketball Academy (BBA) – the elite training centre for the MHP RIESEN Ludwigsburg club. The commitment is not just about supporting high-quality sports coaching but also about the social and personal development of young people. Through its “Talents Hand in Hand” initiative, Porsche, together with its partner clubs and social institutions, also conveys values like tolerance, passion and respect to young people. It also promotes the embracing of topics like inclusion, environmental awareness and health. The famous patron of the Development Programme is the football World Cup winner Sami Khedira.

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  • See interstellar comet 3I/ATLAS zoom through solar system in new telescope imagery (video)

    See interstellar comet 3I/ATLAS zoom through solar system in new telescope imagery (video)

    The European Southern Observatory (ESO) has captured the clearest images yet of the interstellar visitor 3I/ATLAS as it moves inward through the solar system.

    ESO’s Very Large Telescope (VLT) snapped new images of the comet just two days after it was discovered, recording a timelapse as the object moved across the sky. The resulting stacked image is the deepest view yet of the interstellar intruder.

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  • Handheld sensors have potential to detect bacteria from volatile organic chemicals in body Labmate Online

    Handheld sensors have potential to detect bacteria from volatile organic chemicals in body Labmate Online


    Tiny sensors similar to alcohol breathalysers could be used to detect bacterial infections and identify antimicrobial resistance (AMR) in bodily fluids, according to an opinion article published in the journal Cell Biomaterials. The authors, a team of engineers, microbiologists and machine learning specialists based in Switzerland, said the technology could lead to affordable, rapid diagnostic tools that would enhance treatment decisions and help address AMR.

    “One of the biggest drivers of AMR is that we lack rapid diagnostics,” said Dr Andreas Güntner, senior author and a mechanical and process engineer at ETH Zurich, who collaborated on the project with Dr Catherine Jutzeler, Dr Thomas Kessler, Professor Emma Slack and Professor Adrian Egli.

    The researchers proposed bypassing conventional multi-step laboratory procedures that can take many hours, days or even weeks, and instead make use of handheld chemical sensors which would be capable of delivering results in seconds or minutes.

    Historically, clinicians have used smell to detect certain infections. For example, Pseudomonas aeruginosa can produce a sweet, grape-like odour, whereas Clostridium infections are associated with a putrid smell. These scents are caused by volatile organic compounds (VOCs), small molecules released by bacteria and other organisms.

    The authors argued that VOCs in blood, urine, faeces or sputum could be measured by specially designed sensors, offering a reliable proxy for the presence of infection. Similar approaches have been used to detect contaminants such as methanol in alcoholic beverages and to monitor air quality.

    “We have already developed and commercialised something similar for detecting methanol. Now, we are trying to transfer this technology to more complex situations,” explained Güntner.

    Because even closely related bacterial strains can emit distinct patterns of VOCs, the approach could help to distinguish those AMR strains. Laboratory studies have already shown that methicillin-resistant Staphylococcus aureus (MRSA) and its non-resistant counterpart can be identified based on their VOC profiles.

    Developing clinically viable sensors, however, presents a significant challenge. The concentration of VOCs is extremely low and detecting them accurately requires materials with high sensitivity.

    “Imagine a room full of a billion tiny blue balls [but] only one red one,” said Güntner. “You must identify that single red ball – and do so within [a few] seconds.”

    The authors envisaged that future devices would incorporate arrays of sensors with varying binding properties, built using metal oxides, polymers, carbon nanotubes, and graphene derivatives. Filters would be required to exclude irrelevant compounds, such as human-derived or ubiquitous VOCs.

    Machine learning would be instrumental in sensor development, enabling algorithms to identify the minimal set of VOCs necessary to detect bacterial species and assess resistance or virulence factors.

    Ultimately, the researchers said their aim was to translate advances in chemical sensing and machine learning into practical diagnostic tools that could be used in everyday medical settings with minimal training.

    “We hope this will improve patient outcomes and support antibiotic stewardship,” said Güntner.


    For further reading please visit: 10.1016/j.celbio.2025.100125 



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  • Aimee Barrett-Theron to referee opening match of Women’s Rugby World Cup 2025

    Aimee Barrett-Theron to referee opening match of Women’s Rugby World Cup 2025

    • Appointments of Emirates World Rugby Match Officials for the 24 Women’s Rugby World Cup 2025 pool matches
    • Three referees to make Rugby World Cup debuts in the middle
    • Sara Cox to become first female to referee 50 tests with Japan v Spain on 7 September
    • Match official profiles are available in the World Rugby Media Zone

    South Africa’s Aimee Barrett-Theron will referee the Women’s Rugby World Cup 2025 opening match between hosts England and 1991 champions USA at the Stadium of Light in Sunderland on 22 August.

    With excitement building around the world as the countdown hits 44 days to go, World Rugby has announced the Emirates Match Official appointments for the 24 matches that make up the pool stage of what promises to be the biggest and best-ever Women’s Rugby World Cup.

    VIEW APPOINTMENTS >>

    In May, a team of 22 Emirates Match Officials (10 referees, six assistant referees and six Television Match Officials) were selected for the showcase event in England, which runs from 22 August to 27 September across eight host locations.

    It will be the second time that the South African official has been handed the honour of refereeing the opening match, having also taken charge of England’s encounter with Spain at Women’s Rugby World Cup 2017 in Ireland.

    A significant milestone will be reached on the last day of the pool stage on 7 September with Sara Cox (England) to become the first female to referee 50 test matches when she takes charge of Japan v Spain at York Community Stadium in York.

    Clara Munarini (Italy) will be in the middle for the final match of the pool stage later that day, the Pool D meeting between France and South Africa at Franklin’s Gardens in Northampton.

    Emirates World Rugby Match Official appointment highlights

    • Aimee Barrett-Theron (South Africa) will be assisted in the opening match by Natarsha Ganley (New Zealand) and Maria Heitor (Portugal) with Leo Colgan (Ireland) as Television Match Official and Rachel Horton (Australia) as Foul Play Review Official.
    • Heitor will become the first Portuguese official on the Rugby World Cup stage.
    • Precious Pazani (Zimbabwe) will follow suit as the first African female from outside South Africa when she is an assistant referee for the other Pool A match on the opening weekend between Australia v Samoa in Manchester a day later.
    • Sara Cox will officiate in her fifth Women’s Rugby World Cup, having had appointments as an assistant referee in 2010 and 2014 before refereeing in the last two tournaments.
    • Natarsha Ganley, Ella Goldsmith (Australia) and Kat Roche (USA) will make their Rugby World Cup refereeing debuts, the latter having been an assistant referee in New Zealand.
    • Goldsmith will take charge of New Zealand’s opening match of their title defence, against Spain in York on 24 August.
    • Four officials will referee three matches in the pool stage in Maggie Cogger-Orr (New Zealand), Cox, Aurélie Groizeleau (France) and Hollie Davidson (Scotland).
    • Groizeleau’s first appointment – Canada v Fiji in York on 23 August – will be her 40th test as a referee, making her the fourth female to reach the milestone after Barrett-Theron, Cox and Davidson.
    • Cox’s third match in the pool stage – Japan v Spain in York on 7 September – will see her become the first female to take charge of 50 tests and the 16th overall in test history.
    • Davidson will referee Brazil’s first-ever Women’s Rugby World Cup match against South Africa in Northampton on 24 August.

    Chair of Emirates World Rugby Match Officials Selection Committee and Executive Board member, Su Carty said: “Firstly, a big congratulations to the match officials, who have earned their place and appointments on merit. Rugby is a team sport, and every step of the way, this group of exceptional people have worked tirelessly as a team to calibrate, review and advance. This will continue throughout Women’s Rugby World Cup 2025. I know that they are all excited in playing their part in facilitating great matches that will be at the heart of an era-defining competition.”

    World Rugby Women’s High Performance Referee Manager Alhambra Nievas said: “Congratulations to all our match officials. Everyone will play their part in the pool phase. With less than 50 days to go, we are all now focused on being the best we can be on and off the field. There is an incredible camaraderie and bond within this group, and I look forward to seeing our team in action, doing what they do best at Women’s Rugby World Cup 2025.”

    Women’s Rugby World Cup 2025 panel

    Referees: Aimee Barrett-Theron (South Africa), Maggie Cogger-Orr (New Zealand), Sara Cox (England), Hollie Davidson (Scotland), Ella Goldsmith (Australia), Natarsha Ganley (New Zealand), Aurélie Groizeleau (France), Lauren Jenner (Italy), Clara Munarini (Italy), Kat Roche (USA).

    Assistant referees: Maria Heitor (Portugal), Jess Ling (Australia), Amelia Luciano (USA), Precious Pazani (Zimbabwe, reserve referee), Amber Stamp-Dunstan (Wales), Holly Wood (England).

    Television Match Officials: Leo Colgan (Ireland), Rachel Horton (Australia), Quinton Immelman (South Africa), Matteo Liperini (Italy), Andrew McMenemy (Scotland), Ian Tempest (England).

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  • Diagnostic dilemma: Orgasm involving a kitchen whisk likely triggered person’s fatal aneurysm

    Diagnostic dilemma: Orgasm involving a kitchen whisk likely triggered person’s fatal aneurysm

    The deceased: A 39-year-old woman in Belgrade, Serbia

    The discovery: The woman’s ex-husband found the woman’s body in her apartment and notified the police. She was lying on her left side on the living room couch, and her body was covered by a blanket.

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  • A multi-target strategy to support healthy aging

    A multi-target strategy to support healthy aging

    Research has identified key mechanisms driving aging and actionable targets for promoting longevity. A promising strategy is to preserve the cell’s ability to produce energy, repair DNA, and stress resilience, with nicotinamide adenine dinucleotide (NAD+) playing a central role. Here, Dr. Rebecca Crews presents a multi-target approach to support healthy aging

    Decades of research have uncovered key mechanisms driving the aging process, identifying actionable targets to support longevity. One of the most promising strategies is preserving the cell’s capacity for energy production, DNA repair, and stress resilience. Central to all of these processes is nicotinamide adenine dinucleotide (NAD+), a coenzyme that fuels hundreds of metabolic reactions, including mitochondrial ATP production and sirtuin-mediated cellular maintenance.

    It is known that NAD+ levels significantly diminish with age. This decline is tightly linked to the hallmarks of aging, contributing to mitochondrial dysfunction, impaired repair, cellular senescence, and age-related damage. Restoring NAD+ levels closer to youthful norms has, therefore, become a major focus within longevity science.

    However, simply boosting NAD+ with precursors addresses only one aspect of a complex issue. A truly effective strategy tackles the root causes of NAD+ decline and maximizes outcomes. Therefore, a thoughtful strategy involves a multi-pronged approach: slowing NAD+ degradation, supporting its synthesis, and improving how NAD+-dependent pathways function (Sharma et al., 2023).

    The foundation: NAD+ precursors

    The most straightforward way to boost NAD+ levels is by supplying the body with its molecular precursors.

    The two most widely used options are:

    • Nicotinamide Riboside (NR) or Nicotinamide Mononucleotide (NMN): Both convert efficiently into NAD+ via the salvage pathway. Human trials consistently report 40–60% increases in blood NAD+ at daily doses of 250–1,000 mg (Conlon & Ford, 2022).

    Choosing between NR, NMN, or using both typically depends on individual goals and cost. Consistent, daily dosing is key to maintaining elevated NAD+ levels.

    Enhancing efficiency: Sirtuin activators

    Many of NAD+’s health benefits stem from its role in fueling sirtuins, a family of NAD+-dependent enzymes that drive DNA repair, metabolic balance, stress resilience, and inflammation control. Sirtuin Activating Compounds (STACs) amplify these protective functions:

    • Resveratrol:
      • A grape polyphenol that directly stimulates SIRT1. Its poor bioavailability is improved when taken with dietary fat or via advanced delivery systems (e.g., liposomal encapsulation, and solid-lipid nanoparticles).
    • Pterostilbene:
      • A blueberry-derived analog of resveratrol that achieves higher plasma levels and may exert stronger SIRT1 activation.

    Combining NAD+ precursors with STACs ensures both ample substrate and maximized sirtuin function (Sharma et al., 2023).

    Protecting the pool: CD38 Inhibitors

    CD38 is a major NADase whose activity increases with age and chronic inflammation, accelerating NAD+ depletion. Inhibiting CD38 conserves existing NAD+, keeping it available for beneficial pathways like sirtuin mediated repair.

    Natural flavonoids have emerged as promising CD38 inhibitors:

    • Apigenin:
      • Abundant in chamomile, parsley, and celery, apigenin blocks CD38 in preclinical models, elevating NAD+ and downstream sirtuin activity. It also delivers anti-inflammatory and antioxidant benefits (Kramer & Johnson, 2024).
    • Quercetin:
      • A common flavonoid found in onions, apples, and berries, quercetin inhibits CD38 and offers potent antioxidant, anti-inflammatory, and senolytic benefits (Chini et al., 2018).

    Flavonoid CD38 inhibitors offer multiple benefits: they simultaneously preserve NAD+, reduce oxidative stress, and curb inflammatory signaling.

    Clearing the way: Senolytics

    Senescent cells accumulate with age, acting as cellular “zombies” that resist death while secreting pro-inflammatory factors (SASP). This SASP, in turn, boosts CD38 in nearby cells, leading to faster NAD+ depletion.

    Key senolytics (compounds that selectively eliminate these “zombie” cells) include:

    • Fisetin: Found in strawberries and apples, this flavonoid has demonstrated the ability to reduce senescent cell burden, enhance health span, and extend lifespan in aged mice (Yousefzadeh et al., 2018).
    • Spermidine: This polyamine, present in fermented foods and legumes, induces autophagy and may support the clearance of senescent cells. It’s associated with improved cardiovascular health and lifespan in mice (Hofer et al., 2022).

    Calming the storm: Anti-inflammatory support

    Chronic inflammation, a hallmark of aging, further depletes NAD+ by increasing CD38 activity. Resolving this inflammation is key to preserving the NAD+ pool and creating a healthier cellular environment:

    • Curcumin: The active compound in turmeric, suppresses NF-κB and COX-2 signaling and may indirectly support sirtuins. Due to poor absorption, high-bioavailability formulations are essential (Hegde et al., 2023).
    • Omega-3 Fatty Acids (EPA & DHA): These fish oil–derived fats integrate into cell membranes to reduce inflammatory signals and serve as building blocks for specialized pro resolving mediators (SPMs) that actively shut down inflammation (Kavani et al., 2022).

    Synergistic anti-inflammatory effects have been observed when curcumin and omega-3 fatty acids are administered together (Saw et al., 2010).

    Integrating the stack: Synergy and practical considerations

    This multi-component stack represents a strategic and comprehensive approach to NAD+ metabolism. NAD+ precursors ensure ample substrate supply, STACs optimize its efficient use, CD38 inhibitors protect against its premature breakdown, senolytics reduce the detrimental burden of senescent ‘zombie’ cells, and targeted anti-inflammatory compounds re- establish cellular homeostasis. The goal is a synergistic effect that promotes overall cellular resilience.

    However, implementation requires attention:

    • Lifestyle first: Supplements cannot replace a foundation of a healthy diet, regular exercise, quality sleep, social connection, and stress management.
    • Gradual introduction: Start supplements one by one (“start low, go slow”) to gauge individual tolerance.
    • Quality is key: Opt for reputable brands that provide third-party testing for purity and potency.
    • Personalization: Monitor biomarkers and subjective well being.

    Conclusion: A balanced perspective on NAD+ optimization

    Supporting NAD+ levels is a promising strategy in the effort to maintain cellular function and health with age. The approach outlined here – boosting NAD+ production, reducing its breakdown, improving how it’s used, and supporting the broader cellular environment – reflects the current understanding of NAD+ as a dynamic and interconnected system.

    NAD+ boosting strategies should be seen as a flexible starting point, not a one-size-fits-all solution. As research advances, more personalized strategies will likely become available, guided by individual health data and deeper insights into NAD+ biology.

    Importantly, NAD+support works best as part of a bigger picture. Lasting health and longevity depend just as much on diet, exercise, sleep, stress management, and social connection. Keeping these foundations strong while staying informed about new science is the most practical way to approach NAD+ optimization today.

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  • Blood flow restriction can match gym gains without joint strain

    Blood flow restriction can match gym gains without joint strain

    Can you build serious strength without heavy weights? A clinical trial comparing resistance training and blood flow restriction methods highlights options for those seeking gains without joint stress.

    Study: Comparative analysis of high-intensity resistance training and blood flow restriction training on enhancing upper limb muscle strength and mass. Image credit: Ground Picture/Shutterstock.com

    A recent paper published in the journal Frontiers in Physiology compares the effects of two types of exercise training on upper limb muscle mass and strength. The results could help redirect people unsuitable for high-intensity training to another alternative.

    Introduction

    High-intensity resistance training (HIRT) is an effective way to achieve upper limb muscle growth, but at a higher risk of damaging the joints, ligaments, or tendons in this injury-prone area. Low-intensity training uses a low training load with more repetitions, increasing the time required. Though it is safer than HIRT, it is also less effective, reducing the final muscle hypertrophy.

    Blood Flow Restriction Training (BFRT) is a low-intensity alternative to HIRT. Also known as KAATSU training, BFRT is a novel method of strength training in which external pressure is applied to the limbs using specially designed pressure equipment. This pressure obstructs venous blood flow completely and arterial flow partly. The outcome is more intense body stimulation at each load level, the goal being to increase muscle strength and size and boost endurance.

    BFRT could be a safe middle path that confers muscle growth and strength comparable to that with HIRT, but with less risk of injury. BFRT combined with short-term intensive strength training improved body composition and cardiac performance, enhancing cardiovascular fitness. This is the case in young and elderly participants after a short-term intervention.

    BFRT has also been demonstrated in the rehabilitation of post-surgical patients, for instance, after anterior cruciate ligament reconstruction. Here, it improves muscle thickness and strength, helping the patient regain function. BFRT also prevents injury in older adults by increasing bone strength and exercise capacity.

    BFRT can be optimized by using an exercise intensity of 20% to 40% of one-repetition maximum strength (1RM) with a high number of repetitions, during two or three sessions per week. Pressure is applied to achieve 50% to 80% vessel blockade, though there is no consensus on whether to use absolute vs progressive pressure. Each of these affects upper limb training adaptation, but they have not been directly compared with each other or with HIRT, prompting the research in the current study.

    This study was a randomized controlled trial involving 34 participants, who were randomly assigned to one of three groups: the HIRT, BRTF with fixed pressure (BFRT-F), or BFRT with progressive pressure (BFRT-P).

    Study findings

    The 1RM increased significantly in all groups, with the best results in the HIRT group, followed by the BFRT-P group.

    The HIRT protocol increased all isokinetic muscle strength parameters. The highest was an increase of over 55% in the triceps extension. Peak torque increased significantly at the shoulder and elbow joints in the HIRT group compared with BFRT-F.

    The BFRT-P group experienced comparable increases in strength of between 30% and 40%. Though increases occurred in the BFRT-F group, the gains were significantly below those in the other groups. With the trunk and back muscle groups, the gains in peak torque were highest for HIRT (~3%) compared to both other groups.  Still, the BFRT-P group showed a marked improvement in peak torque compared to BFRT-F.

    Despite being inferior to the other groups’ outcomes, the BFRT-F also showed significantly higher peak torque in several joint extensors and flexors.

    The HIRT and BFRT-P groups, but not the BFRT-F group, demonstrated increased arm muscle circumference, especially during muscle contraction, signaling muscle hypertrophy. The most significant increase occurred in the HIRT group.

    Muscle mass increased in both the HIRT and BFRT-P groups. In the HIRT group, this increase was about 15.1% and 22.6% in the left and right arms, respectively, and 5.2% and 10.6% in the BFRT-P group, for the left and right arms, respectively. The BFRT-F group failed to show any significant change.  

    These findings followed the predicted pattern, probably because progressive pressure with BFRT-P causes greater metabolic stress. This, in turn, induces more hypoxia and results in the accumulation of metabolites in the muscle, the probable reason for its superiority to BFRT-F.

    Conclusion

    The study presents the first direct and controlled comparison of high-intensity resistance training with two blood flow restriction training modalities. It demonstrated that the best results were obtained with HIRT, confirming, as expected, “HIRT’s role as the gold standard for mechanical tension-driven adaptations”. In contrast, the BFRT-F group had the lowest gains.

    Notably, the BFRT-F group used a lower load at 30% 1RM but still showed strength gains, indicating that BFRT does play a role in improving strength. Certain studies suggest that BFRT can build muscle strength comparably to HIRT, but possibly only in trained individuals. BFRT may be especially important in training among older men, where it has sometimes been shown to be nearly as effective as HIRT, though the results are conflicting.

    The authors noted that using fixed, absolute pressures instead of individualized arterial occlusion pressures may have limited BFRT’s full potential. They also acknowledge the absence of a low-intensity resistance training group with BFRT, which limits comparisons between BFRT and conventional low-load training. Additionally, muscle strength was estimated using an indirect 1RM formula rather than measured directly, introducing possible error.

    While HIRT is optimal for strength and hypertrophy, BFRT-P is a viable alternative for individuals contraindicated to high-intensity training.” The findings suggest that pressure progression may be crucial in maximizing results with BFRT. Future studies should explore the role of personalized arterial occlusion pressures and include a low-intensity control group to provide controls for low-load training without the effect of BFRT.

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