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  • Fonseca flies past Fearnley on Wimbledon debut – ATP Tour

    1. Fonseca flies past Fearnley on Wimbledon debut  ATP Tour
    2. ‘I know everything is possible’: Teenager João Fonseca on Wimbledon, football and Federer  The Guardian
    3. ATP Wimbledon Best Bets Including Fonseca vs Fearnley  Last Word On Sports
    4. Fonseca expects Brazilian fans to bring the noise at Wimbledon  France 24
    5. Joao Fonseca Says He’s Adapting to the Unpredictability of the ATP Ahead of Wimbledon  MSN

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  • Elden Ring Switch 2 Could Be Releasing Sooner Than Expected

    Elden Ring Switch 2 Could Be Releasing Sooner Than Expected

    Elden Ring Tarnished Edition has recently been rated by the Entertainment Software Rating Board. With the ESRB finalizing its review of the game, it could mean the Elden Ring Switch 2 edition could be launching sooner than some expected.

    ‘Elden Ring’ Switch 2 Release Date Could be hinted at with ESRB Rating completed

    Screenshot: FromSoftware, Nintendo

    Although Elden Ring Tarnished Edition was initially revealed during the Switch 2 Direct in April, no release date was given at the time. However, the popular FromSoftware RPG was recently rated by the ESRB for Nintendo’s console on June 30. This could actually give us an idea when we can expect the much-anticipated port.

    Once a title is rated by ESRB, they sometimes release 4 to 6 months after it. “Sometimes” being the important keyword here, as this isn’t always the case. But it’s true for a lot of games. With FromSoftware stating that Elden Ring Switch 2 was set to launch “sometime in 2025”, it could launch on Switch 2 anytime between August through December. So while there is no guarantee, it looks like the game isn’t going to be delayed into 2026, as some fans had worried.

    'Elden Ring' Switch 2 ESRB Rating
    Screenshot: ESRB

    As a side note, I can’t help but be amused reading ESRB’s rating of Elden Ring Switch 2 edition. “ELDEN RING Tarnished Edition is rated M for Mature 17+ by the ESRB with Blood and Gore, Language, Suggestive Themes, and Violence. During the course of the game, a humanoid monster is depicted partially nude, with scales/scars covering its breast and pelvic regions. The word “sh*t” appears in the dialogue.” I sometimes forget how weird Elden Ring gets. The fact that we can play it on a Nintendo console is just kind of mind-blowing, as a 90s kid.

    'Elden Ring' Story Trailer
    Screenshot: FromSoftware

    With a Nintendo Switch 2 Direct rumored to be happening in July, some have theorized that the release date for Elden Ring Tarnished Edition could be announced then. Although the “leaked” Direct also claims a Metaphor: ReFantazio port is also going to be revealed at the event. Maybe it’s just me, but this is starting to sound a little too good to be true. But hey, you never know!

    Another thing I’m curious about is how Elden Ring will actually perform on Switch 2. There is no way that it actually runs at 60 FPS, as it struggles to maintain that on PS5. But if FromSoftware is able to keep it locked at 30 FPS with decent graphics, it could be the best way to play the open-world RPG on the go. I’ve actually beaten the game on my Asus ROG, and it’s far from perfect.

    FromSoftware is teaming up with Nintendo again, with the release of The Duskbloods. The exclusive multiplayer is scheduled to launch sometime in 2026. So Elden Ring releasing in 2025 would be a good warm-up for players diving into FromSoftware for the first time. Then again, you can play Dark Souls right now on Nintendo Switch 2. Even if it doesn’t have an upgraded version, it still runs decently!


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  • Athlete Refugee Team: Seyd Taha Ghafari’s journey | News | Athletics Better World

    Athlete Refugee Team: Seyd Taha Ghafari’s journey | News | Athletics Better World


    This feature is the second in a five-part series sharing the stories of refugee athletes Farida Abaroge, Seyd Taha Ghafari, Omar Hassan, Emmanuel Kiruhura Ntagunga and Seyfu Jamaal Tahir as they seek selection to the Athlete Refugee Team (ART) at the World Athletics Championships Tokyo 25. 

     

    After taking on work that put his life in danger, Seyd Taha Ghafari was forced to flee Iran, leaving everything he knew behind. 

    Ghafari was unable to see his family for five long years. When he arrived in the UK with no certainties, he found strength and connection through running. 

    Running became his lifeline, helping him to navigate a new world, build a community and regain hope.

    “I continued to run, because it gives you good feeling – mentally and physically,” explains the 30-year-old, who ran for the Athlete Refugee Team at the World Athletics Cross Country Championships in Bathurst in 2023.

    “I saw my family briefly. That was a very sad moment. You don’t only leave your family, you leave your friends and everything you’ve built, just like that.

    “A big motivation for me when I arrived was that I saw so many people running in the parks and on the roads in the UK. I felt really good. I felt like I knew all of them. I started running again and it felt like home.

    “As marathon runners, we have lots of long runs. Many things in your mind come and go. I’m always thinking about my past, and what a great opportunity I have.”

    View the full video feature on World Athletics Watch.

     

    Video features on Farida Abaroge, Emmanuel Kiruhura Ntagunga and Seyfu Jamaal Tahir will be published on World Athletics Watch during the next few weeks. The feature on Omar Hassan is already available.

    Interview and video production by Christel Saneh for World Athletics

     

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  • UN Development Programme welcomes historic agreement on sustainable development even amidst global turmoil – ReliefWeb

    1. UN Development Programme welcomes historic agreement on sustainable development even amidst global turmoil  ReliefWeb
    2. Finance Minister Aurangzeb attends key global development financing conference in Spain  Ptv.com.pk
    3. UN chief seeks aid surge to check ‘climate chaos’  Dawn
    4. Invest in aid to build peace in troubled world: UN  Geo.tv
    5. The world is overcharging Africa — and paying the price in lost growth  TheBanker.com

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  • Life At The Extremes: Maximally Divergent Microbes With Similar Genomic Signatures Linked To Extreme Environments

    Life At The Extremes: Maximally Divergent Microbes With Similar Genomic Signatures Linked To Extreme Environments

    Multi-layered pipeline for identifying bacterium/archaeon pairs with similar genomic signatures. Layer 1: Five selected non-parametric clustering methods identify clusters of organisms with similar genomic signatures. The clusters containing both bacteria and archaea (green) generate a list of 78 candidate bacterium–archaeon pairs, grouped by these algorithms based on their similar genomic signatures. Layer 2-a:: The candidate pairs from Layer 1 undergo pairwise distance calculations between their FCGRs using four different distance metrics. Only 40 pairs, with the majority of distances below empirically determined thresholds, are retained. Layer 2-b: In parallel to FCGR comparison, a biological analysis is conducted on the output pairs from Layer 1. This includes checking environment labels and examining metadata about their living environments to select pairs isolated from similar types of extreme environments, resulting in 20 pairs. The final output is a list of 15 bacterium/archaeon pairs (comprising 16 unique genera and 20 unique species) that passed all filtering layers. These pairs can confidently be proposed as maximally divergent microbes that share similar genomic signatures associated with their living environments. — biorxiv.org

    Extreme environments impose strong mutation and selection pressures that drive distinctive, yet understudied, genomic adaptations in extremophiles.

    In this study, we identify 15 bacterium–archaeon pairs that exhibit highly similar k-mer–based genomic signatures despite maximal taxonomic divergence, suggesting that shared environmental conditions can produce convergent, genome-wide patterns that transcend evolutionary distance. To uncover these patterns, we developed a computational pipeline to select a composite genome proxy assembled from non-contiguous subsequences of the genome.

    Using supervised machine learning on a curated dataset of 693 extremophile microbial genomes, we found that 6-mers and 100 kbp genome proxy lengths provide the best balance between classification accuracy and computational efficiency. Our results provide conclusive evidence of the pervasive nature of k-mer–based patterns across the genome, and uncover the presence of taxonomic and environmental components that persist across all regions of the genome.

    The 15 bacterium-archaeon pairs identified by our method as having similar genomic signatures were validated through multiple independent analyses, including 3-mer frequency profile comparisons, phenotypic trait similarity, and geographic co-occurrence data. These complementary validations confirmed that extreme environmental pressures can override traditionally recognized taxonomic components at the whole-genome level.

    Together, these findings reveal that adaptation to extreme conditions can carry robust, taxonomic domain-spanning imprints on microbial genomes, offering new insight into the relationship between environmental mutagenesis and selection and genome-wide evolutionary convergence.

    Life at the extremes: Maximally divergent microbes with similar genomic signatures linked to extreme environments, biorxiv.org

    Astrobiology

    Explorers Club Fellow, ex-NASA Space Station Payload manager/space biologist, Away Teams, Journalist, Lapsed climber, Synaesthete, Na’Vi-Jedi-Freman-Buddhist-mix, ASL, Devon Island and Everest Base Camp veteran, (he/him) 🖖🏻

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  • Xbox Needs to Get Weirder or Die Trying

    Xbox Needs to Get Weirder or Die Trying

    Xbox is in a weird place right now, and I’m not the only one who thinks so. In fact, people with more important opinions on the subject than myself seem to agree: if Microsoft doesn’t get its shit together on hardware, the box as we know it is cooked. Laura Fryer, the former director of the Xbox Advanced Technology Group for the original Xbox project back in May 2000 and former executive producer for Microsoft Games Studios up until the Xbox 360 days, put it bluntly in a recent video.

    “Obviously, as one of the founding members of the Xbox team, I’m not pleased with where things are today. I don’t love watching all of the value that I helped create slowly get eroded away,” Fryer said in a video on YouTube. “I’m sad because, from my perspective, it looks like Xbox has no desire—or literally can’t—ship hardware anymore. So, this partnership is about a slow exit from the hardware business completely. Personally, I think Xbox hardware is dead.”

    The partnership that Fryer is referring to is, of course, the Xbox and Asus team-up that will see the release of the ROG Xbox Ally handheld that was announced at Computex earlier this month. The criticism from within the games industry and fans is that Microsoft didn’t design the handheld device, instead outsourcing the work to Asus, which modified its existing ROG Ally X handheld PCs, and then slapped Xbox software onto it. Was it laziness on Microsoft and Xbox’s part? Or is it afraid to commit to Xbox hardware?

    Ouch. As rough as those words may be, it’s hard not to agree. Out of the gate, Xbox’s current generation of consoles, the Series S and X, were all but trounced by Sony and the PS5, the latter of which snatched a commanding 70 percent of the market share in the first five years of both consoles’ lives. There are a lot of reasons for that, and arguably the biggest is that PlayStation had the exclusive titles that made people actually want to buy a console. But pinning it on game exclusives doesn’t paint the full picture. Part of the problem is that Xbox, for all its past Gamer with a capital “G” glory, got boring. So yes, Xbox is in a weird place right now, but people still want consoles, which means it’s time for them to get even weirder—yes, I’m talking hardware, too.

    First, let’s start with the boring box that Xbox houses all of that X in. It sucks. It’s a snooze that makes year-over-year smartphone design feel innovative. Sure, it’s sterile and can mesh with your new-build city-dwelling decor, but it’s also—on the downside—half-assed. If you’re selling people hardware that plays games, they ought to know that it’s a console and not a VCR you forgot to sell in 1997. Say what you will about the PS5 (it’s ugly; that’s the only correct opinion), but Sony took a swing with it. It made sure that everyone who bought one felt like they were buying a console, and like it or not, you eat with your eyes. If you want to give people a reason to buy your console, maybe try giving them a reason. Nintendo did that with the Switch in 2017, and as far as I can tell, that’s going (checks watch) really f*cking well.

    Speaking of the Switch, Xbox should probably find a way to differentiate its hardware functionality-wise. As dominant as the PS5 has been in the console business, it’s still fundamentally the same machine as the Xbox. That’s a shame, considering Xbox had ample opportunities to bring hardware in exciting new directions over the years. Not to be the Kinect guy, but damn did Microsoft bungle XR big time—and then again, it bungled XR with the HoloLens. In the multiverse, there’s a timeline where Xbox used its experiments with XR via the Kinect and HoloLens to snatch value from the trembling hands of Sony and Meta’s Quest headsets. That is not this timeline, as we all know, but if it really wants to give Xbox a future worth financing, maybe there’s still room to take those more daring expeditions into gaming and refresh them for today’s age.

    © Adriano Contreras / Gizmodo

    The last thing Xbox needs to do to get weird is a little more nebulous—it needs a new identity. Sure, Game Pass has been a ray of light in an otherwise dim outlook for Xbox, but turning the consoles into subscription machines doesn’t exactly scream, “We see you gamers, and we hear you.” Xbox can still continue to sell Game Pass subscriptions, don’t get me wrong—I love Game Pass, and being able to stream games on devices like the Quest 3 feels like a revelation to me. But the emphasis on Xbox being the thing that gets you to the thing makes hardware feel like an afterthought. Gaming on a console that you’ve spent $500 on should feel native; it should feel complete; it should feel like an Xbox, not a PC. That goes back to game exclusives, partly. Sony has had no issues getting weird with its exclusives—Death Stranding, for example, is one of the weirdest games you can play, and now Death Stranding 2 is a PS5 exclusive, which is apparently devastating some gamers. Sucks for them, but it’s kind of a huge win for PlayStation. It’s also more proof that Xbox doesn’t need to be the Netflix of gaming; it needs weird, magnetic titles that make its console feel experiential.

    As you may have gathered, this would all be kind of a huge shift for Xbox, and it’s debatable whether Microsoft even has the will to make any of it work. I know the last few years have been lackluster for Xbox, but people still want consoles, and the recent success of the Switch 2 all but proves that. Nintendo, for its part, didn’t earn that success the easy way. It took a gamble with the Switch by redefining its hardware, pivoting inward towards games, and ended up releasing the defining console of our generation. That’s all to say, the ball is in your court, Microsoft. Are you going to go out with a bland, forgettable box? Or get weird and, at the very least, go down swinging?

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  • Maria Cornejo Shifts Her Business Strategy

    Maria Cornejo Shifts Her Business Strategy

    Maria Cornejo, winner of the Geoffrey Beene Lifetime Achievement Award, poses with Laura Linney at the 2023 CFDA Fashion Awards.Photo: Getty Images

    On Saturday, Zero Maria Cornejo made an announcement on Instagram: “Starting with fall 2025, our focus will shift to the best-selling styles that have become beloved parts of our wardrobes, with an emphasis on producing mindfully with upcycled fabrics in our archives.”

    Mindful design—meaning sourcing responsibly made fabrics or using her own leftover inventory—has been at the heart of Cornejo’s practice for years, but this is different. Cornejo and her business partner Marysia Woroniecka are adjusting the way they operate. Relying on existing patterns won’t just eliminate the costs of product development, it will also free up Cornejo for other projects: She’s been organizing her storage facility with an eye to donating pieces to museums in the US and Europe.

    Cornejo opened her first store in NoLIta in 1998 and her vision was clear from the beginning. A preference for geometric cuts that never fail to flatter the body helped her build an arty, avant garde clientele: artist Cindy Sherman, model Stella Tennant, actress Chloe Sevigny, jewelry designer Jill Platner. Ten years later, she moved into the boutique she occupies today on Bleecker Street, leading a revitalization of her block. In 2023 she won the Geoffrey Beene Lifetime Achievement Award from the CFDA.

    Independent designers have been hard hit by the economic downturn that began last year, and the situation has only been exacerbated by the US administration’s tariff changes. But the Zero Maria Cornejo brand has a couple of factors going for it: Cornejo has always favored timelessness over trends, and the consistency of her vision has produced a loyal client base. Plus: she’s been designing for 27 years, she has a lot of patterns at her fingertips.

    “My goal was always to make clothes that were good heirlooms or good vintage, and not to be disposable,” she said over Zoom. “Of course, I love fashion, but I do like the idea of things being sort of ageless and having longer than a season’s worth of life. And I think the clients like that.” Indeed they seem to. In the comments section of her Instagram post, one customer wrote: “I’ve worn your long Issa dress in a few different fabrics for as long as you’ve made it. Another cheered the decision. “Here’s to the classics! Here’s to evolution!”

    Cornejo is all positivity on that Zoom call. “I think it’s a good model, because I think people are really overwhelmed. People are visually oversaturated.” There does seem to be a movement toward simplicity afoot. “We’re giving clients what they want,” said Cornejo. “And we won’t have to work as hard. It’s also like a life decision, you know. We think it will liberate us to get organized and sort of see what, what other things we could do, what other opportunities there are.”

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  • Emma Meesseman, Belgian Cats rewrite history with EuroBasket victory

    Emma Meesseman, Belgian Cats rewrite history with EuroBasket victory

    Emma Meesseman produces magic

    At the heart of it all was Meesseman. The 32-year-old forward delivered another complete performance in the final: 16 points, 11 rebounds, 7 assists, 5 steals and 2 blocks. She was everywhere, orchestrating the offence, anchoring the defence and leading with the calm authority of a veteran who has seen – and done – it all. Her efforts earned her a second consecutive EuroBasket MVP award, adding to a glittering resume that includes a WNBA championship, WNBA FInals MVP award, six EuroLeague titles and three EuroLeague MVP awards, further cementing her legacy as one of the all-time greats in women’s basketball.

    “It’s still hard to believe,” Meeseman told FIBA after the game. “I have had a lot of games in my career but not one like that before and especially not in a final. It’s a good reminder to never give up – in sport or in life.”

    When asked about becoming the first woman to receive back-to-back EuroBasket MVP awards, the 6ft 4in (1.93m) superstar was typically humble in her response.

    “If individual awards come along then I am fine with that, but I will always be most proud of this trophy and the team that I did it with,” she said.

    “Especially where we came from. It’s not like we ever had a history like France or Spain. We just did it with this group. This [MVP award] might be catching some dust, but this [the gold medal] will always be on show. It’s the thing I will remember always.”

    “I do like writing history, though.”

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  • Pakistan: Flash floods, rains kill 22 in Khyber Pakhtunkhwa in five days – ANI News

    1. Pakistan: Flash floods, rains kill 22 in Khyber Pakhtunkhwa in five days  ANI News
    2. 22 killed, 11 injured in KP rain and floods since June 25: PDMA  Dawn
    3. Widespread Rain, thunderstorms forecast across Pakistan; Flash flood warning issued for upper Regions  Ptv.com.pk
    4. Civic infrastructure caves in to single rain spell  The Express Tribune
    5. KE field teams up to task as monsoon hits Karachi  Business Recorder

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  • MRD-Guided Ibrutinib Plus Venetoclax Effective in R/R CLL

    MRD-Guided Ibrutinib Plus Venetoclax Effective in R/R CLL

    Minimal residual disease (MRD)-guided cessation and reinitiation of ibrutinib (Imbruvica; Johnson & Johnson) plus venetoclax (Venclexta; Genentech, Abbvie) is a safe treatment approach for patients with relapsed or refractory chronic lymphocytic leukemia (CLL), a new report suggests.1 The study, which was published in Blood Advances, suggests that MRD-guided therapy offers a way to balance the risks of cessation with those of cumulative toxicity.

    The combination of the Bruton tyrosine kinase (BTK) inhibitor ibrutinib and the BCL-2 inhibitor venetoclax has become a transformative therapeutic option for people with relapsed or refractory CLL, the authors noted. It is sometimes combined with CD20-targeting monoclonal antibodies. Yet, it is not curative, and it comes with significant concerns.

    “While continuous treatment may lead to cumulative toxicity or resistance, fixed-duration treatment may lead to undertreatment and early relapse,” they wrote.

    The combination of ibrutinib and venetoclax has become a transformative therapeutic option for people with relapsed or refractory CLL. | Image Credit: © CLL cells – sovova

    One possible solution, the authors wrote, is the use of MRD to guide therapy. Previous research has shown that undetectable MRD following treatment is an independent prognostic indicator of progression-free and overall survival (PFS and OS, respectively) in patients with CLL.2 However, at the time the investigators initiated their trial, there had not been any studies specifically examining response-guided, time-limited use of ibrutinib plus venetoclax in relapsed or refractory CLL.1

    In the phase 2 VISION/HOVON141 trial (NCT03226301), a subset of patients had undetectable MRD (sensitivity < 10-4 assessed by flow cytometry; abbreviated as uMRD4) in the bone marrow and peripheral blood after 15 cycles of venetoclax plus ibrutinib.3 Those patients could safely stop therapy, the authors found. The new report expands on those findings with updated 4-year follow-up data.1

    A total of 225 patients, treated at 47 sites across 6 European countries, were initially enrolled in the trial. Patients who achieved uMRD4 after 15 cycles (n = 72) were randomized on a 1:2 basis to continue on ibrutinib until toxicity or progression (n = 24) or to stop treatment after the 15th cycle (n = 48). In the cessation cohort, patients were reinitiated on ibrutinib and venetoclax if they met the threshold of detectable MRD (≥ 10-2; abbreviated as dMRD2). Patients who were MRD4 positive (dMRD4) after cycle 15 remained on ibrutinib.

    The investigators found that, at a median follow-up of 51.7 months, the estimated 4-year OS rate was 88%, the 4-year PFS rate was 81%, and 14% of participants required another line of therapy. Within the cessation cohort, 40% of participants reinstated therapy due to dMRD2.

    However, there was no statistically significant gap between the different cohorts. Within the ibrutinib maintenance arm, the OS was 95%, PFS was 90%, and next-therapy rate was 14%. For those in the cessation arm, the OS was 91%, PFS was 85%, and the next-therapy rate was 12%. Among those who continued on ibrutinib because they did not achieve uMRD4 after 15 weeks, the OS was 86%, PFS was 76%, and next-therapy rate was 19%.

    “Importantly, PFS rates were equally high in patients randomized to MRD-guided treatment cessation and reinitiation, emphasizing the potential to reduce treatment exposure and toxicity by MRD-guided treatment in the R/R CLL setting,” the authors wrote.

    They concluded that the cessation and reinitiation of ibrutinib plus venetoclax for relapsed or refractory CLL is feasible and results in lower toxicity compared to indefinite therapy with a BTK inhibitor.

    “The MRD-guided approach may also allow for improved patient compliance, thus offering an alternative to the high discontinuation rate reported outside clinical trials for continuous BTK inhibitors,” they concluded.

    References

    1. Niemann CU, Dubois J, Nasserinejad K, et al. Long-term follow-up of MRD-guided treatment of ibrutinib plus venetoclax for relapsed CLL: phase 2 VISION/HO141 trial. Blood Adv. Published online April 18, 2025. doi:10.1182/bloodadvances.2024015180

    2. Wierda WG, Rawstron A, Cymbalista F, et al. Measurable residual disease in chronic lymphocytic leukemia: expert review and consensus recommendations. Leukemia. 2021;35(11):3059-3072. doi:10.1038/s41375-021-01241-1

    3. Kater AP, Levin MD, Dubois J, et al. Minimal residual disease-guided stop and start of venetoclax plus ibrutinib for patients with relapsed or refractory chronic lymphocytic leukaemia (HOVON141/VISION): primary analysis of an open-label, randomised, phase 2 trial. Lancet Oncol. 2022;23(6):818-828. doi:10.1016/S1470-2045(22)00220-0

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