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  • How an experiment at Fermilab fixed a hole in the Standard Model

    How an experiment at Fermilab fixed a hole in the Standard Model

    Twenty-five years ago, there was a hole in the Standard Model. And on July 21, 2000, an experiment called DONUT filled it.

    That’s when a team of 54 physicists from the United States, Japan, South Korea and Greece announced the first-ever detection of the tau neutrino, one of the last unseen particles in the Standard Model of particle physics. They were part of the Direct Observation of the Nu Tau, or DONUT, collaboration based at the U.S. Department of Energy’s Fermi National Accelerator Laboratory.

    “We knew there was a tau neutrino — there had to be,” said Regina Rameika, a member of DONUT at the time and now associate director for high-energy physics at the Department of Energy. “But the fact is, we never had observed the signature of the interaction.”

    Byron Lundberg and Regina Rameika with the DONUT detector. Credit Reidar Hahn, Fermilab

    Neutrinos are incredibly lightweight subatomic particles that were first postulated by Wolfgang Pauli in 1930. In 1956, physicists saw the first neutrino at the Savannah River Plant in South Carolina. They didn’t know about the neutrino’s different types, or flavors, at the time, but this first neutrino turned out to be an electron neutrino. In 1962, physicists at Brookhaven National Laboratory detected the second type, the muon neutrino.

    The idea of a third flavor of neutrino materialized after an experiment led by physicist Martin Perl at SLAC National Laboratory found a particle called the tau in 1975. The tau is the third generation of particles known as leptons. Since the other two leptons — electrons and muons — had corresponding neutrinos, it made sense that there must also be neutrinos corresponding to the tau. Sure enough, experiments found indirect evidence for the tau neutrino’s existence.

    But direct observational evidence remained scarce. Until DONUT.

    Making DONUT

    In the early 1990s, Fermilab physicists were gearing up for the Neutrinos at the Main Injector project, or NuMI, to search for neutrino mass. As the story goes, Fermilab scientists Rameika and Byron Lundberg were discussing how excited they were for NuMI and realized it would be very useful to directly observe the tau neutrino first. The idea for the DONUT experiment was born.

    Lundberg and Rameika reunited a group of scientists who had worked on Fermilab’s Experiment 653 in the mid-1980s. E653 incorporated emulsion plates developed by physicists at Nagoya University in Japan to look for charm particles. DONUT would use similar technology to search for evidence of tau neutrinos.

    The DONUT collaboration submitted their proposal in 1994 and were taking data by 1997.

    “By today’s standards, it was actually relatively simple,” said Rameika. “Combined, it was difficult.”

    One challenge for DONUT was shoehorning it into the existing Fermilab program. The lab was uniquely equipped for this experiment because the Tevatron’s 800-GeV proton beam was essential for achieving the flux and energies they required to have even a chance of detecting tau neutrinos. But other experiments needed the beam, too. To make the effort as easy as possible for the lab, the collaboration repurposed existing equipment.

    The experiment consisted of a 3-foot-long structure made of iron plates sandwiched with plates of emulsion. When Fermilab’s Tevatron accelerator shot a beam of particles at this target, the neutrinos interacted with the iron nuclei. The resulting particles shot through the emulsion plates, leaving tracks behind like animal footprints in the snow.

    Smashing protons into a tungsten block, DONUT physicists produced many particles, including tau neutrinos. To minimize background and to avoid overexposure of the target emulsion, physicists installed magnets and shielding to remove all particles except neutrinos from the beam, leading to a pure neutrino beam hitting the DONUT target. Credit: Fermilab
    Smashing protons into a tungsten block, DONUT physicists produced many particles, including tau neutrinos. To minimize background and to avoid overexposure of the target emulsion, physicists installed magnets and shielding to remove all particles except neutrinos from the beam, leading to a pure neutrino beam hitting the DONUT target. Credit: Fermilab

    But if the experimenters weren’t careful, the emulsion plates could get polluted. The Tevatron beam produced an enormous amount of muons in addition to neutrinos, and these muons would overexpose the emulsion plates. Fortunately, since muons are charged particles, they can be steered with magnets, which don’t affect neutrinos.

    Vittorio Paolone, who was co-spokesperson for DONUT with Lundberg at the time, compared the muon challenge to being between the jaws of a lion. “You have the jaws open, and then you have to stick the emulsion in between and hope it doesn’t clamp down at some point,” he said.

    If the metaphorical jaws did clamp down, muons would flood the emulsion plates and DONUT would lose all their data. It would be akin to exposing a roll of film to the light before developing the photos. There were safeguards in place to protect the data: if the sweeping magnets failed, the beamline would automatically shut off. Fortunately for DONUT — and for every other Fermilab experiment using the beam at the same time — the magnet held steady.

    With Fermilab’s high-energy proton beam, the nuclear emulsion technology pioneered by Nagoya University and the sweeping magnet system that shielded the detector, DONUT was the product of scientific serendipity. “The detection of tau-neutrino interactions using particle accelerators was only possible because three unique capabilities could be employed in a synergistic manner at the time DONUT was proposed,” said Lundberg.

    After collecting data from 1997 to 1998, collaborators in Nagoya worked on digitizing and analyzing the emulsion plates. They then sent the data back to Fermilab for further analysis, which included early forms of machine learning and artificial intelligence. “We were one of the first experiments using neural networks,” said Rameika.

    In 1986, Vittorio Paolone poses inside the magnet used to eliminate charged particles from the neutrino beam. Credit: Reidar Hahn, Fermilab
    In 1986, Vittorio Paolone poses inside the magnet used to eliminate charged particles from the neutrino beam. Credit: Reidar Hahn, Fermilab

    In total, DONUT collected 6.6 million particle interactions, which they narrowed down to about 1,000 candidate events.

    If tau neutrinos acted as predicted, physicists expected to see their tell-tale signature in the emulsion plates: a short track with a kink in it, indicating a tau neutrino had hit an iron nucleus and produced a tau lepton, which traveled for about a millimeter before decaying.

    “The signature is pretty obvious,” said Paolone, now a professor at the University of Pittsburgh. “Even though it looks exactly the way you expect it to look, when you start seeing three or four that look like a tau neutrino interaction … you start to get pretty excited.”

    On July 21, 2000, Lundberg announced the detections of four tau neutrino interactions to a packed lecture hall at Fermilab. They had finally seen the penultimate piece of the Standard Model. (The observation of the final piece, the Higgs boson, would be announced 12 years later.) Ultimately, DONUT found a total of nine tau neutrino interactions.

    “Personally, commissioning and running DONUT was challenging and exhausting,” said Lundberg. “I never worked as intensely after the experiment — I doubt that I even could have.”

    The long legacy of a short interaction

    The hard work of a small, international group of physicists had a profound impact on the field. In 2022, the American Physical Society recognized the achievements of DONUT by awarding the W.K.H. Panofsky Prize in Experimental Particle Physics to Lundberg, Rameika, Paolone and their Nagoya University collaborator Kimio Niwa “for the first direct observation of the tau neutrino through its charged-current interactions in an emulsion detector.”

    The emulsion detection technology originated at DONUT has since been used in many more experiments, including ScanPyramids, an international project using noninvasive techniques to look for hidden chambers inside the pyramids in Egypt. CERN neutrino experiments like DsTau, FASERν and SND@LHC also utilize this tech. “The origin of the current nuclear emulsion technology is in the DONUT experiment,” said Mitsuhiro Nakamura, a DONUT collaborator from Nagoya University who recently retired from physics to become a rice farmer.

    Nuclear emulsion plates were also used in the OPERA experiment at the Gran Sasso Laboratory of the Italian National Institute for Nuclear Physics. Between 2010 and 2015, OPERA saw 10 beam-produced muon neutrinos oscillate into tau neutrinos, making it one of two experiments that has detected tau neutrinos since their first observation. The other is the IceCube Neutrino Observatory, which announced seven tau neutrino candidates from cosmic sources in 2024 and a few more in following analyses. Collectively, physicists have seen, on average, one tau neutrino per year in the last quarter century.

    “It’s impressive that we don’t have larger samples,” said Paolone. “It’s an amazingly difficult particle to detect.”

    Many current and future experiments are focused on detecting — or have a chance of seeing — tau neutrinos. In addition to the CERN emulsion-based detectors that will look at energies similar to and higher than to DONUT, there are large-scale water- and ice-based detectors like KM3NeT, P-ONE and an expansion to IceCube that will probe high-energy neutrinos, and proposed tau-neutrino telescopes will explore ultra-high-energy ranges.

    Fermilab physicists packed a lecture hall at the laboratory to hear DONUT co-spokesperson Byron Lundberg announce the first direct evidence for the tau neutrino at a colloquium on July 21, 2000. Credit: Fermilab

    Physicists are also continuously brainstorming new ways to study tau neutrinos. “Ever since DONUT, we’ve had to learn how to find the tau neutrino signature without actually seeing the track,” said Rameika.

    Some new-generation neutrino experiments, such as the Deep Underground Neutrino Experiment hosted by Fermilab, are focusing on the other two neutrino flavors that are relatively easier to detect.

    Still, DONUT’s direct detection of the tau neutrino was a vital step in understanding the nature of the elusive particle.

    “In order to understand neutrinos, you want to look at every channel that you possibly can,” said Rameika. “Knowing how to detect tau neutrinos, as we did with DONUT, is an important piece of information that we keep in the back of our heads for going forward and figuring out how to adapt it. In my mind, it was a critical historical experiment”

    Fermi National Accelerator Laboratory is supported by the Office of Science of the U.S. Department of Energy. The Office of Science is the single largest supporter of basic research in the physical sciences in the United States and is working to address some of the most pressing challenges of our time. For more information, please visit science.energy.gov.

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  • Laser Implosion Mimics Neutron Star Magnetic Field

    Laser Implosion Mimics Neutron Star Magnetic Field

    Researchers at The University of Osaka have developed a novel method for generating ultrahigh magnetic fields via laser-driven implosions of blade-structured microtubes. This method achieves field strengths approaching one megatesla—a breakthrough in compact, high-field plasma science.

    Ultrastrong magnetic fields approaching the megatesla regime—comparable to those found near strongly magnetized neutron stars or astrophysical jets—have now been demonstrated in theory using a compact, laser-driven setup. A team led by Professor Masakatsu Murakami at The University of Osaka has proposed and simulated a unique scheme that uses micron-sized hollow cylinders with internal blades to achieve these field levels.

    The technique—called bladed microtube implosion (BMI)—relies on directing ultra-intense, femtosecond laser pulses at a cylindrical target with sawtooth-like inner blades. These blades cause the imploding plasma to swirl asymmetrically, generating circulating currents near the center. The resulting loop current self-consistently produces an intense axial magnetic field exceeding 500 kilotesla, approaching the megatesla regime. No externally applied seed field is required.

    This mechanism stands in stark contrast to traditional magnetic compression, which relies on amplifying an initial magnetic field. In BMI, the field is generated from scratch—driven purely by laser-plasma interactions. Moreover, as long as the target incorporates structures that break cylindrical symmetry, high magnetic fields can still be robustly generated. The process forms a feedback loop in which flows of charged particles—composed of ions and electrons—strengthen the magnetic field, which in turn confines those flows more tightly, further amplifying the field.

    “This approach offers a powerful new way to create and study extreme magnetic fields in a compact format,” says Prof. Murakami. “It provides an experimental bridge between laboratory plasmas and the astrophysical universe.”

    Potential applications include:

    • Laboratory astrophysics: mimicking magnetized jets and stellar interiors
    • Laser fusion: advancing proton-beam fast ignition schemes
    • High-field QED: probing non-linear quantum phenomena

    Simulations were conducted using the fully relativistic EPOCH code on the SQUID supercomputer at The University of Osaka. A supporting analytic model was also constructed to reveal the fundamental scaling laws and target optimization strategies.

    Funding: Japan Society for the Promotion of Science (JSPS), Kansai Electric Power Company (KEPCO)

    Simulations: Performed using the SQUID supercomputer at The University of Osaka

    /Public Release. This material from the originating organization/author(s) might be of the point-in-time nature, and edited for clarity, style and length. Mirage.News does not take institutional positions or sides, and all views, positions, and conclusions expressed herein are solely those of the author(s).View in full here.

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  • The 13-inch M2 MacBook Air is a great back-to-school deal at just $699

    The 13-inch M2 MacBook Air is a great back-to-school deal at just $699

    It’s almost back to school season, and we’re starting to see some great laptop deals trickle in as a result. Walmart continues to sell the M1-powered MacBook Air for $599, but if you want more power and a sleeker design, the 13-inch M2-powered MacBook Air starts at just $699 ($100 off) from Best Buy. That’s its best price to date, and it’s available on the configuration that offers 256GB of storage and 16GB of RAM, double what’s in the base M1 model.

    The M2-powered MacBook Air remains an excellent jack-of-all-trades, with more than enough power for work, casual gaming, and even a bit of light video editing. It also brings a few welcome upgrades over the M1 model, including faster performance and a much better 1080p webcam that’s noticeably sharper. Design-wise, it’s thinner and lighter, with slimmer bezels and a brighter, slightly bigger display. It also includes an improved keyboard and a MagSafe port for charging, while retaining features like a long battery life that should last a full work day.

    That said, as an older laptop, you’ll miss out on newer features. Apple’s latest MacBook Air runs on a more powerful chip, for one thing, can connect to two external displays as opposed to just one, and offers an even more impressive 12-megapixel Center Stage webcam. But if all you care about is buying a fast, reliable laptop for everyday work and play, the M2-MacBook Air is a great investment to make at this price.

    Three more worthwhile deals

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  • ‘10’ mural for Lamine Yamal in Rocafonda

    ‘10’ mural for Lamine Yamal in Rocafonda

    A very special mural has appeared in Rocafonda in form of graffiti art with the number ‘10’ for Lamine Yamal. The local 304 postcode has again made waves further afield thanks to the new FC Barcelona number 10. It’s a gesture that deserves recognition and praise. This is why FC Barcelona have dedicated a mural to him in the Mataró neighbourhood where he grew up. 

    Where it all began

    Rocafonda has become the centre of attention once again thanks to Lamine Yamal. This time it’s for an art-piece; with one of the walls showing the young La Masia graduate and his new jersey number. It’s specifically at the park where he used to play football as a boy. It’s not just any mural, it’s a tribute to a boy whose dreams began in that park and who now wears a jersey steeped in history.

    The inside of the number 10 features some of his most memorable moments while wearing blaugrana. The graffiti has been carefully curated to show his journey from La Masia through to becoming the number 10 for the first team. 

    Lamine Yamal has put Rocafonda on the map and the Club wanted to connect with his roots and pay tribute to the place it all began. A neighbourhood with its most notable contemporary figure in form of a large mural depicting the FC Barcelona star, who turned just 18 years old on 13 July. A young age that still doesn’t stop him from becoming a prophet in his own land, and it is now there for all to see in the form of a stunning mural. A piece of art that exudes quality, or as the contemporaries of Lamine Yamal would say, aura.  

    Art calls for art, because Lamine Yamal is a wizard with the ball at his feet on the pitch. His creativity has now been transferred into another art form, a mural featuring his portrait. He still has many more pictures to paint while wearing the FC Barcelona jersey too.  

     

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  • Steam now bans games that violate the ‘rules and standards’ of payment processors and banks

    Steam now bans games that violate the ‘rules and standards’ of payment processors and banks

    Steam has added a new rule to its guidelines that has resulted in certain games getting banned, . The new clause states that “content that may violate the rules and standards set forth by Steam’s payment processors and related card networks and banks, or internet network providers” is not allowed and could result in removal from the platform.

    In other words, if credit card companies get mad about something, they could actually have the power to ban a game. The clause that this will affect “certain kinds of adult-only content.”

    This has likely already resulted in many games . The vast majority of these titles have obvious sexual themes and many have the word “incest” in the title. SteamDB doesn’t give a reason for these removals, but the timing does match up.

    To view this content, you’ll need to update your privacy settings. Please click here and view the “Content and social-media partners” setting to do so.

    This move might sound unusual on its face, but payment processors have consistently fought against being used to purchase adult content. These battles are typically instigated on the notion that adults-only platforms don’t have enough safeguards in place against illegal content.

    Mastercard and Visa blocked the in 2020. Mastercard went a step further in 2021, “Speciality Merchant Registration” requirements that announced “banks that connect merchants to our network will need to certify that the seller of adult content has effective controls in place to monitor, block and, where necessary, take down all illegal content.”

    I doubt you’ll find too many people upset that games with titles like Sex Adventures – Incest Family were removed from the platform, but it could set a potentially troubling precedent. Some Steam users are upset with this rule change the “quiet normalization of financial censorship.”

    In other words, if gigantic financial institutions get to decide what is appropriate and what is not, who is to say it won’t eventually impact regular games? One Steam user notes that “queer content gets flagged as ‘explicit’ even when it’s PG,” which is a . One user “looks innocuous at first glance but it’s a trojan horse.”

    On the flipside, Steam has been home to some truly foul content over the years. We’ve reached out to Valve to ask for a comment on this news and will update this post when we hear back.


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  • Testing All ED Patients Boosts Hepatitis C Detection – Docwire News

    Testing All ED Patients Boosts Hepatitis C Detection – Docwire News

    1. Testing All ED Patients Boosts Hepatitis C Detection  Docwire News
    2. Screening all patients for hepatitis C testing in ED may find more cases than targeted approach  CIDRAP
    3. Top 5 Infectious Disease News Stories Week of July 5-12  Contagion Live
    4. Hep C Screening in the ED; Post-Pandemic Life Expectancy  MedPage Today
    5. Universal Hepatitis C Screening in EDs Detects More Infections, But Gaps in Care Remain  Contagion Live

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  • Mavericks two-way signee Ryan Nembhard

    Mavericks two-way signee Ryan Nembhard

    Ryan Nembhard has averaged 11.3 points and 6.7 assists through 3 games at NBA Summer League in Las Vegas.

    • Download the NBA App
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    Editor’s Note: Read more NBA coverage from The Athletic here. The views on this page do not necessarily reflect the views of the NBA or its teams. 

    * * *

    The January 2021 meeting between Montverde Academy and IMG Academy was stuffed with star power.

    Montverde had future NBA lottery pick Jalen Duren and eventual pros Dariq Whitehead and Caleb Houstan on its roster.

    IMG, meanwhile, put two future NBA lottery picks, Jarace Walker and Jett Howard, on the floor, and started another soon-to-be pro, current Charlotte Hornets center Moussa Diabaté.

    “Between us and IMG, we had like nine guys in the top 50,” said Kevin Boyle, who was Montverde’s boys basketball coach for 14 years. “I’m like, ‘The best guy in the gym is Ryan Nembhard. And he’s the only one not ranked.’”

    In Boyle’s eyes, that meeting between the two Florida prep school powerhouses was more proof that Nembhard was not to be underestimated. The Aurora, Canada native was his usual rock-solid self, notching 10 points, five rebounds and four assists. Montverde hung on to beat IMG 55-51, part of its 24-1 season.

    Nembhard played two years at Creighton and then two years at Gonzaga. As a senior in Spokane, Wash., he led the nation in assists. His 181 assists in West Coast Conference play were a conference record. He racked up nearly four assists for every one turnover.

    Nembhard is allergic to making low-percentage plays, but his size prevented him from being a first-round pick. At the NBA Draft Combine, Nembhard was measured at 5-feet-11, sans shoes, while weighing 176 pounds.

    In June, Nembhard agreed to sign a two-way contract with the Dallas Mavericks in undrafted free agency. Through three games at NBA Summer League, he has been a steadying presence, averaging 11.3 points (40.6 percent shooting) and 6.7 assists.

    “I’ve been kind of dealing with it my whole life,” Nembhard said about being an undersized guard. “I am who I am. I’m not going to grow much more. I’m just looking to build on this opportunity I’m getting. At a certain point, the height won’t be talked about anymore. At the end of the day, you just have to roll the ball out and play hoops.”

    Nembhard tries to emulate other diminutive guards such as Chris Paul, Kyle Lowry and Fred VanVleet. Defensively, Nembhard likes what he sees from New Orleans Pelicans pest Jose Alvarado, who picks up ballhandlers full court and stays attached to their chests once they cross the half-court line.

    There’s one other player Nembhard models his game after, too.

    “Obviously, my brother,” he said.

    Andrew Nembhard is three years older than Ryan. The Indiana Pacers took him with the 31st pick in the 2022 NBA draft. A 6-foot-4 combo guard, Andrew has become an essential part of a Pacers team that advanced to the Eastern Conference Finals a year ago and were one win away from being crowned NBA champions in June.

    Ryan attended Game 7 of the NBA Finals in Oklahoma City. As gut-wrenching as it was to watch Pacers guard Tyrese Haliburton go down with an Achilles tear in the first quarter, Nembhard was still proud that his older brother’s team had the 68-win Thunder on the ropes before the injury.

    “Everyone thought Indy was going to be out and it was going to be a quick series,” Nembhard said. “They showed their fight.”

    Boyle coached both Nembhard brothers at Montverde. Before the 2022 NBA Draft, he warned teams not to discount how much Andrew could impact a game’s outcome. Before this year’s draft, he was spreading a similar message about Ryan.

    “With Andrew, I was telling so many teams to draft him and take him,” Boyle said. “About three teams came to me and said, ‘We should have took him.’ Both brothers are elite at decision-making and knowing how to play.”

    In the Mavericks’ first Summer League game against the Los Angeles Lakers, Nembhard showed his savviness. He played on and off the ball, with Dallas giving heavy point guard reps to No. 1 pick Cooper Flagg. Nembhard finished with 21 points on 8-of-14 shooting and five assists. While he had a bad game against the San Antonio Spurs two days later (scoring two points on 1-of-10 shooting), Nembhard rebounded Monday against the Charlotte Hornets, tallying 11 points and eight assists in Dallas’ loss.

    “He has such a command of the game and command of the floor,” said Mavericks assistant Josh Broghamer, who’s coaching Dallas in Las Vegas. “He’s always going to have those guys set. Where he wants them to be. And he’s already reading that second, that third layer of the defense before he comes off (the screen).”

    Nembhard faces an uphill battle in the NBA because of his size. But the Canadian pick-and-roll maestro has a chance to make an impact in the league because of his headiness.

    Kyrie Irving is expected to be sidelined for most of the upcoming season while he recovers from a torn ACL. The Mavericks signed D’Angelo Russell — another former Montverde player — to fill in at starting point guard in Irving’s place. Behind Russell, the Mavericks have Dante Exum, Brandon Williams and potentially Nembhard, depending on how quickly he can adapt.

    “They showed the most love (during the predraft process),” Nembhard said. “I think they really wanted me. They showed the most care for me. And I feel like I have a chance to come do something over here.”

    ***

    Christian Clark is an NBA reporter for The Athletic who is based in Dallas. Previously, he covered the New Orleans Pelicans for NOLA.com | The Times-Picayune. Follow Christian on Twitter @cclark_13

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  • Major martyred, three India-backed terrorists killed in Balochistan IBO

    Major martyred, three India-backed terrorists killed in Balochistan IBO

    Listen to article

    A Pakistan Army major was martyred during an intelligence-based operation (IBO) in Balochistan’s Awaran district that killed three Indian-sponsored terrorists, the military’s media wing said on Wednesday.

    According to the Inter-Services Public Relations (ISPR), the operation was launched on confirmed intelligence regarding the presence of terrorists belonging to Fitna-al-Hindustan, an Indian proxy group operating in the region.

    “Security forces effectively engaged the terrorist hideout,” the statement read, adding, “As a result of the intense exchange of fire, three Indian-sponsored terrorists were sent to hell.”

    Read More: Three killed, several injured in gun attack on passenger coach in Kalat

    However, during the engagement, Major Syed Rabnawaz Tariq, 34, a resident of Muzaffarabad, embraced martyrdom. The ISPR said the brave officer was leading his troops from the front and fought gallantly before laying down his life in the line of duty.

    A sanitisation operation is underway in the area to eliminate any remaining threats, the statement added.

    “The security forces of Pakistan remain determined to root out the menace of Indian-sponsored terrorism,” the ISPR stated. “Such noble sacrifices of our brave men only strengthen the nation’s resolve to eradicate terrorism from the country,” it added.

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  • Data Shows Amoxicillin Therapy Resistances for Invasive Pneumococcal Disease

    Data Shows Amoxicillin Therapy Resistances for Invasive Pneumococcal Disease

    Amoxicillin therapy had not been associated with an increased risk of resistance for patients with a nonfatal McCabe score who had invasive pneumococcal disease (IPD). However, investigators of a study published in Antimicrobial Agents and Chemotherapy found that it was associated with increased resistance for patients who were in the ultimately fatal or rapidly fatal groups.1

    New research reveals amoxicillin’s effectiveness varies in treating invasive pneumococcal disease, highlighting the importance of patient-specific factors in antibiotic therapy. | Image Credit: Maksym Yemelyanov – stock.adobe.com

    “Amoxicillin is one of the most commonly used antibiotics to treat pneumococcal pneumonia,” the study authors said.1 “Furthermore, it is also employed in stewardship programs to reduce the antimicrobial spectrum and switch to oral administration.”

    Pneumococcal disease is caused by Streptococcus pneumoniae and can cause mild symptoms like sinusitis, pneumonia, sepsis, or bacterial meningitis. The bacteria can also cause meningitis and otitis media, according to the CDC. Treatment typically includes antibiotics, but prescribers might try several antibiotics, as the infection can become resistant to antibiotics. For mild infections, prescribers might also recommend pain relievers.2,3

    Vaccination is the best way to prevent IPD, with the CDC recommending vaccination for all children younger than 5 years old, patients aged 5 through 49 years old with certain risk factors, and adults 50 years and older. There are 2 types of vaccination: pneumococcal conjugate vaccines (PCVs) and pneumococcal polysaccharide vaccines. Pneumococcal disease is common for young children, but older adults are at the greatest risk of severe illness and death, according to the CDC.3,4

    Investigators aimed to determine the potential impact of elevated minimum inhibitory concentrations (MIC) in antibiotics, specifically in epidemiology, molecular basis, and clinical impact. Further, they are going to explore the potential role of amoxicillin in treatment and antibiotic de-escalation in the context of IPD, according to the study authors.1

    The study was observational in nature and included a hospital with 700 beds that admitted patients 18 years and older in the Barcelona metropolitan area. Data included sex, age, origin of infection, acquisition, comorbidities, severity of underlying diseases, treatment, and 30-day mortality. From 1994 to 2020, there were 1663 Spneumoniae isolates collected, and approximately 98% of isolates had data on serotypes, with 7 serotypes accounting for over half of cases: 3, 14, 19A, 1, 8, 7F, and 9V.1

    The proportion of isolates susceptible to amoxicillin increased over time from 72.9% from 1994 to 2001 to 91.4% from 2016 to 2020. For MICs greater than 0.5 to 2 mg/L, there was a drastic reduction of isolates from 22.3% to 3.3%, respectively, according to the study authors. For those with isolated greater than 2 mg/L, the numbers remained relatively stable at 4.8% and 5.3%, respectively. For nonsusceptible isolates, the most common vaccine serotypes were 14, 9V, and 23F before PCVs were introduced and 19A and 11A after the introduction of PCVs.1

    As for clinical outcomes, 1527 cases were included for analysis, with patients having a median age of 62.4 years and 36.7% being women. Patients who were older and had a worse prognosis (an ultimately/rapidly fatal McCabe score) were more likely to have amoxicillin-resistant isolates. Furthermore, patients with malignancies (38.5%) and under immunosuppressive therapy (29.7%) were more likely to be amoxicillin resistant.1

    “Amoxicillin therapy was independently associated with increased mortality in patients in the McCabe ultimately/rapidly fatal groups, but not in patients in the non-fatal group. These data are interesting as they indicate variations in antimicrobial efficacy based on the host’s status,” the authors stated.1 “Taken together, these results highlight that prescribing a specific antimicrobial should always be accompanied by a thorough evaluation of the host’s comorbidities and the severity of the infection.”

    READ MORE: Pneumococcal Resource Center

    Ready to impress your pharmacy colleagues with the latest drug information, industry trends, and patient care tips? Sign up today for our free Drug Topics newsletter.

    REFERENCES
    1. Càmara J, Grau I, González-Díaz A, et al. Amoxicillin-non-susceptible Streptococcus pneumoniae causing invasive pneumonia: serotypes, clones, and clinical impact. Antimicrob Agents Chemother. Published online July 8, 2025. doi:10.1128/aac.00237-25
    2. CDC. About Pneumococcal Disease. Updated October 21, 2024. Accessed July 16, 2025. https://www.cdc.gov/pneumococcal/about/index.html
    3. Cleveland Clinic. Pneumococcal Disease. Updated September 27, 2022. Accessed July 16, 2025. https://my.clevelandclinic.org/health/diseases/24231-pneumococcal-disease
    4. CDC. Pneumococcal Vaccination. Updated October 26, 2024. Accessed July 16, 2025. https://www.cdc.gov/pneumococcal/vaccines/index.html

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  • Cyberpunk 2077’s next update adds ‘AutoDrive’ and VRR for consoles

    Cyberpunk 2077’s next update adds ‘AutoDrive’ and VRR for consoles

    Cyberpunk 2077’s Update 2.3, set to launch on Thursday for Mac, PC, PlayStation 5, and Xbox Series X / S, will add a bunch of new features focused around vehicles and proper VRR support on consoles.

    The new AutoDrive feature, available in all cars and motorcycles, lets you drive from place to place automatically. You can set where you want to go on the game’s map, including driving directly to where you need to go for a quest. (The feature only works on roads, though.) You can also use AutoDrive in a “wandering” mode that lets the car just drive around on its own.

    While AutoDrive is on, you can turn on a “cinematic camera” mode to see some more dramatic shots. And if you’d prefer to get a taxi ride from the Delamain AI, that’s an option in Update 2.3 as well once you’ve completed a specific quest.

    With Update 2.3, CD Projekt Red (CDPR) is also adding official in-game support for VRR on both PS5 and Xbox that can help with screen tearing when the frame rate drops. It was already supported at the system level, but the game’s makers say that implementing VRR properly should improve the experience, which can come in handy when you’re running in performance mode on consoles.

    On PC, the update adds support for AMD FSR 3.1, Intel XeSS 2.0, and HDR 10 Plus. Support for AMD’s FSR 4 is being added, too, but you won’t be able to turn it on in-game until you’ve installed the driver that supports it, and that driver won’t be available until a “later date,” CDPR says.

    The game will launch on Mac on Thursday, though you’ll need an Apple Silicon Mac with at least 16GB of unified memory to be able to play it. Cyberpunk 2077 was also a launch title for the Nintendo Switch 2, and Update 2.3 will come to the platform “at a later date.”

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