In a phase III trial (part of the STAMPEDE platform) reported in The Lancet Oncology, Gillessen et al investigated the survival outcomes of adding metformin to standard of care (SOC) in nondiabetic patients with metastatic hormone-sensitive prostate cancer starting androgen-deprivation therapy (ADT).
Study Details
In the open-label trial, 1,874 patients from sites in the United Kingdom and Switzerland were randomly assigned between September 2016 and March 2023 to receive SOC (n = 938) or metformin at 850 mg twice daily plus SOC (n = 936). Standard of care consisted of ADT with or without radiotherapy and with or without docetaxel or an androgen receptor pathway inhibitor (ARPI; docetaxel vs abiraterone, enzalutamide, or apalutamide). The primary endpoint was overall survival.
Key Findings
Median time to most recent patient follow-up was 60 months (interquartile range [IQR] = 49–72 months). Median overall survival was 67.4 months (IQR = 32.5 months to not reached) in the metformin-SOC group vs 61.8 months (IQR = 29.7 months to not reached) in the SOC group (hazard ratio [HR] = 0.91, 95% confidence interval [CI] = 0.80–1.03, P = .15).
Grade ≥ 3 adverse events occurred in 57% of the metformin-SOC group vs 52% of the SOC group, with grade ≥ 3 gastrointestinal adverse events in 9% vs 7%; no differences in grade ≥ 3 events in other body systems were observed.
Weight gain was significantly lower in the metformin-SOC group at 24, 48, and 104 weeks (all P < .0001). Among 583 patients with body weight data available at baseline and at 104 weeks, those in the metformin-SOC group gained a mean of 2.00 kg (95% CI = 1.31–2.69 kg) vs 4.40 kg (95% CI = 3.57–5.24 kg) in the SOC group (mean difference = –2.48 kg, 95% CI = –3.55 to –1.41 kg).
The investigators concluded: “We did not find significant evidence of an overall survival benefit of adding metformin to SOC in the overall population of patients with metastatic hormone-sensitive prostate cancer. The side-effect profile of metformin was as expected and consisted mainly of diarrhea. Adverse metabolic side effects of ADT were significantly reduced in the metformin group compared with the standard of care group.”
Silke Gillessen, MD, of the Institute of Oncology of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona, is the corresponding author for The Lancet Oncology article.
Disclosure: The study was funded by Cancer Research UK, Prostate Cancer UK, and UK Research and Innovation Medical Research Council. For full disclosures of all study authors, visit The Lancet Oncology.
Collectible company Sideshow is teaming up with Pokémon to create a new line of collectible statues, the first of which is a Pokédex-size version of Pokémon #0025, Pikachu. The lovable Mouse Pokémon will be brought to life as a stunning figure that perfectly captures its cuteness and personality. From its bright red cheeks to its distinctive lightning bolt-shaped tail, this high-end collectible will make you feel like the iconic Pokémon is hanging out in your home.
The Pikachu Life-Size Figure measures 18.5 inches tall (including its base) and 17.6 inches wide, with a circular base that’s 9.8 inches deep. At that size, this beautiful statue is sure to amp up your Pokémon collection. You can preorder this Pikachu statue now—directly from Sideshow.
If you can’t get enough of Sideshow’s incredible statues, prepare for the next entry in its Pokémon collection: a Charizard statue that is scaled to a perfect size for display. Stay tuned for more information about this tribute to the popular Flame Pokémon.
Summer holidays over, Albert Ferrer’s Barça Legends team will travel to Mexico to take on a Tigres Leyendas team in the city of Monterrey. The game will be on 31 August, kick off 6pm local time (2am CEST the following day) in the Estadio Universitario, known as ‘El Volcán’, which holds 42,000 fans. For the game players such as Andrés Iniesta, David Villa and Rafa Márquez will be available, the latter now assistant coach to a Mexican national side who recently claimed the CONCACAF Gold Cup.
The rest of the Barça squad for the game against the Mexican legends side will be named in the coming weeks. Tigres are one of the most famous clubs in Mexico and have won the league title on eight occasions, most recently in 2023. The Leyendas side will contain former Tigres players Lucas Lobos, Jesús Dueñas, Rafael Sobis, Juninho, Hugo Ayala, Israel Jiménez and Egidio Arévalo.
Who are the Barça Legends
Barça Legends is a Club-managed programme that was created in 2016 to integrate former Barça players into a permanent professional project with the Club to help spread the Barça brand and present the Club’s values around the world. Over 80 players have participated in at least one match since Barça Legends began.
With just three years to go until the Olympic Games LA28, the LA28 Organising Committee has officially confirmed the competition schedule and format for volleyball and beach volleyball. Both sports are set to shine once again as part of the Games programme which will take place from 14-30 July 2028.
As previously announced, beach volleyball will be held at Alamitos Beach in the City of Long Beach, a designated LA28 Venue City. This stunning seaside location promises a spectacular backdrop for one of the Olympic Games’ most thrilling and visually iconic events. Volleyball will be held at the Anaheim Arena, a premier entertainment and sports venue that will undoubtedly provide a great Olympic stage for an unforgettable volleyball experience.
For beach volleyball, the Preliminary Rounds will take place from Saturday 15 to Saturday 22 July, with three sessions per day for both the men’s and women’s competitions (excluding Saturday 22 July where there will be two sessions). The R16 will occur on Sunday 23 to Monday 24 July inclusive, with four sessions in each competition.
Quarter finalists will battle it out on Tuesday 25 and Wednesday 26 July with both an afternoon and an evening session, before the semi-finalists in both competitions go head-to-head on Thursday 27 July. The men’s and women’s beach volleyball champions will be crowned on the evenings of Friday, 28 July and Saturday, 29 July.
For volleyball, the Preliminary Rounds are set to begin on the same day as beach volleyball, Saturday 15 July, and end on Sunday 23 July. Each day of the Preliminary Rounds will include four sessions for both the men’s and women’s competitions.
Quarter Finals for both competitions will take place across four sessions on Monday 24 and Tuesday 25 July before the final four teams in each gender battle it out in the semifinals on Wednesday 26 July and Thursday 27 July. The men’s and women’s bronze and gold medal matches will take place across Friday 28 July through Sunday 30 July which will mark the final volleyball match of the Olympic Games LA28.
This announcement follows the extraordinary success of the Olympic Games Paris 2024, widely hailed as one of the most successful Games ever for volleyball and beach volleyball. From record-breaking global viewership to world-class performances and iconic settings, the sport captivated global audiences and solidified its status as a fan favourite.
The FIVB will continue working closely with the LA28 Organising Committee to support the delivery of a truly memorable few weeks for the Global Volleyball Movement.
*Please note that, as with previous Games, this provisional competition schedule will remain subject to change through to Games-time in 2028. Later this year, LA28 will release a more detailed competition schedule outlining the specific gender order for each tournament for the 2028 Games.
When the Princess of Wales returned to royal duties following chemotherapy treatment last year, fans quickly clocked that she had added a new eternity ring to her collection, believed to be Cartier’s Étincelle de Cartier wedding band. Over the past year, Kate has often been photographed wearing the $6,300 platinum ring, comprising 19 brilliant-cut diamonds and 19 brilliant-cut sapphires, in lieu of her more famous 12-carat oval-cut Ceylon sapphire engagement ring, which Prince William inherited from Princess Diana following her death.
There was much discussion about why the Princess was wearing her new Cartier ring—often paired with her wedding band and another diamond eternity ring, believed to have been gifted by William to mark Prince George’s birth in 2013—instead of her larger engagement ring. Perhaps it was simply a more everyday choice (Kate has tended to wear the latter at more formal events, such as last year’s Festival of Remembrance at Royal Albert Hall.)
The Princess of Wales wore her two eternity bands with her 12-carat oval-cut Ceylon sapphire engagement ring for the first time at Wimbledon over the weekend.
Photo: Getty Images
But at Wimbledon at the weekend, Kate wore her engagement ring with both of her eternity rings, as well as her wedding band, for the first time. It comes as ring stacking is becoming increasing popular—particularly among new brides. “We’re increasingly seeing clients choose to style their eternity ring stacked with their engagement ring and wedding band, or wear it alone for a more relaxed look,” Eliza Walter, founder of Lylie Jewellery, tells Vogue. “In warmer months or during summer holidays, many opt to wear just their wedding band and eternity ring together—a combination that feels both effortless and meaningful.”
Of course, eternity rings are often deeply meaningful, traditionally bought to mark special milestones (there is speculation that Kate’s Étincelle de Cartier wedding band was gifted to her by William to mark their 13th wedding anniversary last year). “Eternity rings are a timeless symbol, a circle of precious metal traditionally set with stones all the way around, representing an unbroken bond and infinite commitment,” jeweler Rachel Boston explains. “The continuous line of diamonds or gemstones is a reminder that, like the ring itself, true love has no beginning or end.”
If Kate’s choice of jewelry at Wimbledon is anything to go by, it seems that the ring stacking trend isn’t going anywhere. All the better if each piece is imbued with sentimental value—a collection that’s been inherited or built up over the years.
Primary results from the phase 2 RAMP 201 trial (NCT04625270) evaluating the combination therapy of avutometinib and defactinib (Avmapki Fakzynja co-pack) for patients with KRAS-mutated recurrent low-grade serous ovarian cancer (LGSOC) show that this dual-pathway inhibition strategy offers a promising new avenue for a patient population with historically limited effective treatment options.1
The results, published in the Journal of Clinical Oncology, demonstrated robust objective response rates (ORR) with the avutometinib and defactinib combination, even in patients who had undergone multiple prior lines of therapy. The ORR was 31% (n = 34/109), with a notably higher response rate of 44% (n = 22/57) observed in patients harboring KRAS mutations. In the KRAS wild-type cohort, the ORR stood at 17% (n = 9/52). A compelling aspect of the data was the significant proportion of patients (82%) experiencing some reduction in target lesions, irrespective of their KRAS mutation status, underscoring the broad potential of this therapeutic approach.
These findings supported the FDA’s accelerated approval of the combination earlier this year, on May 8, 2025.2
Furthermore, the trial’s efficacy data highlighted durable responses and meaningful progression-free survival (PFS).1 The median PFS for the overall study population was 12.9 months. For KRAS-mutant patients, this extended to an impressive 31.0 months, while KRAS wild-type patients achieved a median PFS of 12.8 months. The median duration of response (DOR) for all patients was 31.1 months. This extended DOR, particularly in a recurrent setting, signals a substantial clinical benefit.
The safety profile of the avutometinib and defactinib combination was generally well tolerated in the RAMP 201 trial, with a 10% discontinuation rate due to adverse events (AEs). Common AEs observed included nausea, diarrhea, and increased creatine phosphokinase levels, consistent with the known mechanisms of action of these inhibitors. Important safety information for the combination includes warnings and precautions regarding potential ocular toxicities, serious skin toxicities, hepatotoxicity, rhabdomyolysis, and embryo-fetal toxicity. Clinicians should be aware of these potential risks and monitor patients accordingly.
These positive outcomes are crucial given the challenges associated with LGSOC, a rare and highly recurrent form of ovarian cancer that affects an estimated 6000 to 8000 patients in the US and 80,000 globally. Distinct from high-grade serous ovarian cancer, LGSOC often presents with a more indolent course but is typically resistant to conventional chemotherapy, leading to high recurrence rates and a persistent need for novel therapies. Approximately 70% of LGSOC cases exhibit mutations within the RAS pathway, with about 30% specifically presenting with a KRAS mutation.
The therapeutic rationale behind the avutometinib and defactinib combination targets key oncogenic pathways. Avutometinib functions as a MEK kinase inhibitor while simultaneously blocking the compensatory reactivation of MEK by RAF. Defactinib, on the other hand, inhibits FAK, a protein recognized for its role in mediating drug resistance. This synergistic inhibition aims to overcome resistance mechanisms often observed in RAS/MAPK pathway-driven cancers, leading to the observed clinical responses.
Beyond the FDA accelerated approval for KRAS-mutated recurrent LGSOC, the clinical implications of the RAMP 201 results are further reflected in the National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines, where the combination is currently a Category 2A recommendation for this specific patient subset. Verastem Oncology has indicated plans to submit the RAMP 201 publication to the NCCN to support the potential inclusion of the KRAS wild-type population in these guidelines, which could expand access to this treatment.
Building on the success of RAMP 201, Verastem Oncology is continuing to advance its research in LGSOC with the ongoing international phase 3 RAMP 301 trial (NCT06072781).3 This pivotal trial is designed to further evaluate the avutometinib and defactinib combination in a broader population of patients with recurrent LGSOC, encompassing both KRAS-mutated and KRAS wild-type disease, aiming to solidify its role as a standard of care.
REFERENCES:
1. Verastem Oncology announces publication of the primary results from the phase 2 RAMP 201 trial of avutometinib in combination with defactinib in patients with recurrent low-grade serous ovarian cancer in the Journal of Clinical Oncology. News release. Verastem Oncology. July 11, 2025. Accessed July 14, 2025. https://tinyurl.com/4w5tndx6
2. FDA grants accelerated approval to the combination of avutometinib and defactinib for KRAS-mutated recurrent low-grade serous ovarian cancer. US FDA. News release. May 8, 2025. Accessed July 14, 2025. https://bit.ly/430Wjzz
3. A study of avutometinib (VS-6766) v. avutometinib (VS-6766) + defactinib in recurrent low-grade serous ovarian cancer with and without a KRAS mutation (RAMP 201). ClincalTrials.gov. Updated January 29, 2025. Accessed July 14, 2025. https://clinicaltrials.gov/study/NCT04625270
Some research suggests older adults may experience benefits from gaming, though effects depend on the type of game. Composite: Guardian/Getty Images
Michelle Statham’s preferred game is Call of Duty. It’s fast and frenetic, involving military and espionage campaigns inspired by real history. She typically spends six hours a day livestreaming to Twitch, chatting to her more than 110,000 followers from her home in Washington state. She boasts about how she’ll beat opponents, and says “bless your heart” while hurtling over rooftops to avoid clusterstrikes of enemy fire. When she’s hit, she “respawns” – or comes back to life at a checkpoint – and jumps right back into the fray.
The military shooter game has a predominantly young male user base, but Statham’s Twitch handle is TacticalGramma – a nod to the 60-year-old’s two grandkids. Her lifelong gaming hobby has become an income stream (she prefers to keep her earnings private, but says she has raised “thousands” for charity), as well as a way to have fun, stay sharp and connect socially.
“A lot of people are surprised that someone my age is playing video games,” Statham admits. She finds the gameplay exhilarating. “When I get really good long sniper shots in, or down someone out of a helicopter, that’s pretty fun,” she says.
Statham juggles in-game multitasking with live-chatting to her multigenerational streaming audience. Younger followers have taught her slang, like the gen Z shibboleth “skibidi”. “I’ve learned some things I don’t want to learn,” she says, laughing. When she tires, she plays privately off-stream to unwind. She also exercises daily, going to the gym with her daughter as part of the 75 Hard fitness challenge, to ensure gaming doesn’t displace physical activity.
Statham is one of the 57 million Americans over 50 who game, a cohort that represents 28% of roughly 205 million total US gamers, shows recent data from the Entertainment Software Association. According to the ESA, nearly half of Americans in their 60s and 70s play some form of PC, mobile or console video game every week, as do 36% of people in their 80s. And as more gamers like Statham enter their golden years, older adults are becoming more visible in the gamer mainstream – sometimes to the confusion of their peers on multiplayer platforms.
Allow Instagram content?
This article includes content provided by Instagram. We ask for your permission before anything is loaded, as they may be using cookies and other technologies. To view this content, click ‘Allow and continue’.
“Age is like having a sign around your neck saying: ‘I’m old and I can’t do this,’” says Will, 72, a Missouri-based retired navy veteran who prefers to keep his last name private, but streams his favorite games, like hunting simulator theHunter: Call of the Wild and air combat game Metalstorm, to 1.4 million YouTube subscribers under the username GrndpaGaming.
“That’s not the case with me and other up-and-coming older gamers that are out there,” says Will. “Someone my age can keep up with technology.”
Some research suggests older adults may experience benefits from gaming, though effects depend on the type of game.
There are games created to help boost memory and attention, such as those by the science-based company BrainHQ, which developed a game called Double Decision often used by researchers to test and improve people’s visual processing, and the Lumosity mobile gaming app, which features a popular brain training game called Train of Thought.
‘Nearly half of Americans in their 60s and 70s play some form of video game every week.’ Photograph: Michelle Statham
More generally, puzzle games like Tetris and Monument Valley, which require players to remember patterns, sequences and spatial layouts, have been shown to help players of any age improve visual memory and cognitive processing. Fitness games that incorporate physical movement, like Ring Fit Adventure or Hot Squat, may improve balance better than conventional rehabilitation in MS patients.
But what about first-person shooter games?
Dr Gregory West, an associate professor in psychology at the University of Montreal, ran a study on participants of all ages in 2018. He found those tasked with hours of playing first-person shooters like Call of Duty experienced a reduction in grey matter in the hippocampal region of the brain. Those who played games involving the exploration of 3D open worlds, like Super Mario 64 or The Legend of Zelda: Breath of the Wild, showed improvement in the same area.
Graphic with three lines of text that say, in bold, ‘Well Actually’, then ‘Read more on living a good life in a complex world,’ then a pinkish-lavender pill-shaped button with white letters that say ‘More from this section’
“A reduced volume in the hippocampus is associated with a risk for neuropsychiatric illness across the lifespan,” explains West. “During ageing, older adults with less activity and grey matter in the hippocampus are at increased risk of developing Alzheimer’s disease.”
But that doesn’t mean older gamers should necessarily stop playing first-person shooters. “It really is a mixed bag when we consider the impact of these games on the ageing brain,” admits West.
Allow Instagram content?
This article includes content provided by Instagram. We ask for your permission before anything is loaded, as they may be using cookies and other technologies. To view this content, click ‘Allow and continue’.
For one, West’s study didn’t focus on how gaming affects older brains specifically, and he notes that older folks who are successful competitive gamers likely have “pretty good cognitive abilities” to begin with.
Then, there are also social benefits that come with gaming on multiplayer platforms, where first-person shooters are popular. “Older adults, through playing video games online with other people and communicating through microphones, are receiving real social stimulation, and I think that positive benefit cannot be ignored even in the face of a possible risk for Alzheimer’s disease,” he says.
“As long as you keep your brain active and functioning, you’re not going to sit there and just deteriorate away,” says Will.
Even amid percussive gunfire, the chats of combat games can be genuinely sweet. “People always say: ‘I love you, Gramps. Keep on doing what you’re doing’… things like that, that really tug at your heart,” says Will.
Gaming can help people with a variety of ailments, says Dr Kris Alexander, a leading authority in video game design and associate professor of media production at Toronto Metropolitan University who helped launch GameRx, an online resource hub for information about wellness and gaming. One 2017 study found that “if you play Tetris within 48 hours of a traumatic experience, you can reduce PTSD”, he tells me. “There are studies that show that if you place burn victims in virtual reality in spaces where they’re surrounded by cold elements, you can reduce their pain.”
Alexander believes gaming can be good for seniors; over a video call, he shows me the custom arcade cabinet he’s built to house every game he’s ever owned. “For my retirement,” he tells me. “Absolutely, when I get older, I’m going to be playing video games.”
However, common conditions like joint pain and vision decline can hinder senior gamers. As that demographic grows, so may demand for accessibility tools. And because the senior player base is relatively small, Alexander acknowledges that the high-budget gaming companies behind blockbuster titles like Call of Duty and Skyrim are unlikely to account for such needs.
In 2010, Will required surgery implanting a steel plate in his skull; since then, if he sits in a chair “for more than 20 or 30 minutes, everything from the shoulders down to the fingertips goes numb”, he says. Now, he uses a hand-shaped gaming keypad called the Azeron Cyborg II, which allows users with limited hand mobility or strength to position PC keys so they’re easy and comfortable to reach. Other adaptive controllers, including voice-control technology, pedals designed for control by foot or mouth, and 3D printable controller modifications for consoles like the Xbox and Playstation, are all making gaming increasingly accessible across playing formats.
Will hopes that other seniors who see him stream will be inspired to get into gaming. “If I can do it at my age with this handicap, you can, too,” he says. After all, you’re never too old to respawn.
KARACHI (Web Desk) – In a major inter-agency operation, the Pakistan Navy (PN), Pakistan Maritime Security Agency (PMSA), Joint Maritime Information Coordination Centre (JMICC), and the Narcotics Control Wing of the Excise, Taxation & Narcotics Control Department (Sindh) have successfully conducted a joint maritime and intelligence-based operation in the Arabian Sea.
The coordinated action involved surveillance missions and real-time maritime patrols, which led to the interception of a stateless vessel operating illegally in the region.
A thorough search of the vessel uncovered over 500 kilograms of narcotics, including hashish and crystal ice (methamphetamine), prepared for illegal distribution.
Illicit liquor confiscation
In a separate intelligence-based operation, the agencies also seized a large quantity of illicit liquor concealed onboard another vessel. The confiscated contraband was intended for unlawful circulation.
The operations were made possible through effective intelligence sharing, seamless coordination, and swift execution by the participating forces.
Contraband worth over Rs1 billion
Authorities estimate the total street value of the seized drugs and liquor at more than Rs1 billion.
The recovered items have been formally handed over to the Excise, Taxation & Narcotics Control Department (Sindh) for further legal proceedings.
The success of these operations demonstrates the enhanced operational synergy between Pakistan’s maritime and law enforcement agencies. It also reaffirms their joint commitment to combating illicit trade, safeguarding national maritime interests, and contributing to regional stability.
The quantum computing revolution draws ever nearer, but the need for a computer that makes correctable errors continues to hold it back.
Through a collaboration with IBM led by Cornell, researchers have brought that revolution one step closer, achieving two major breakthroughs. First, they demonstrated an error-resistant implementation of universal quantum gates, the essential building blocks of quantum computation. Second, they showcased the power of a topological quantum computer in solving hard problems that a conventional computer couldn’t manage.
In “Realizing String-Net Condensation: Fibonacci Anyon Braiding for Universal Gates and Sampling Chromatic Polynomials” published in Nature Communications July 6, an international collaboration between researchers at IBM, Cornell, Harvard University and the Weizman Institute of Science demonstrated, for the first time, the ability to encode information by braiding – moving in a particular order – Fibonacci string net condensate (Fib SNC) anyons, which are exotic quasi-particles, in two dimensional space.
“This is really the first step towards universal topological quantum computing, or fault tolerant computing,” said co-corresponding author Eun-Ah Kim, Hans A. Bethe Professor of physics in the College of Arts and Sciences.
“The two-dimensionality is very important for being very fault tolerant and resistant to error. If you only do everything in one dimension, there is no such potential for fault tolerance,” said co-corresponding author Chao-Ming Jian, assistant professor of physics (A&S).
The researchers demonstrated the power of their method on a known hard problem, rather than one invented for the experiment. On a small scale, they could verify the quantum computer’s results using a classical computer as a proof of principle.
The hard problem they chose involved chromatic polynomials, originated from a counting problem of graphs with different colored nodes and a few simple rules. Classical computers can calculate how many possible colorings are allowed in a simple graph with just a few nodes and a few colors. But as soon as the graph enlarges with many nodes and many connections, the number of possibilities quickly becomes exponentially large. A classical computer cannot compute that many possibilities.
The protocol the researchers used – sampling the chromatic polynomials for a set of different graphs where the number of colors is the golden ratio – is scalable, so other researchers with quantum computers can duplicate it at a larger scale.
“Someone can follow our protocol and do something that is classically not possible,” said Kim. “We set it out as a challenge to anybody.”
Studying topologically ordered many-body quantum systems – systems with a large number of interacting quantum particles – and their applications in quantum computation presents tremendous challenges for quantum researchers. Being able to draw on the resources, expertise and insight of scientists from around the world – in both industry and academia – for their team was essential to achieve their results, said Kim.
“The researchers at IBM were critical in understanding the theory of the topological state and how to design a protocol to implement it on a quantum computer, which they provided,” she said. “Our other colleagues made essential contributions with the hardware simulations, connecting theory to experiment and determining our strategy.”
Co-authors include Zlatko K. Minev, Swarnadeep Majumder and Guanyu Zhu, IBM Quantum, T.J. Watson Research Center; Khadijeh Najafi, IBM Quantum, T.J. Watson Research Center and MIT-IBM Watson AI Lab; Juven Wang, Harvard University and the London Institute for Mathematical Sciences, Royal Institution, U.K.; and Ady Stern, Weizmann Institute of Science, Israel.
The research was supported by the National Science Foundation, the U.S. Department of Energy and the Alfred P. Sloan Foundation.
Chelsea’s Club World Cup win proves they are ready to win the Premier League or Champions League as soon as next season, says defender Levi Colwill.
The 22-year-old started the shock 3-0 win over Paris Saint-Germain in New Jersey’s MetLife Stadium, which crowned the Blues became world champions for the next four years in Fifa’s expanded global tournament.
Asked whether Chelsea can build on that success to win either the Premier League or Champions League, Colwill replied: “Yeah, definitely.
He added: “I said at the start of this tournament that our plan is to win it and people looked at me as if I was crazy. So I’m going to say the exact same thing now going into the Premier League and Champions League.
“This is the biggest trophy I’ve ever won. I think the Club World Cup will be bigger than the Champions League and we were the first team to win it.
“It was a statement victory and, in the future, if we keep winning trophies then everyone will give us the love that we deserve.
“But we’ll only know that in he future. I think we’re ready and we’ll see next season.”