Blog

  • Trump says Musk is ‘off the rails’ and calls his new political party ‘ridiculous’ | Trump administration

    Trump says Musk is ‘off the rails’ and calls his new political party ‘ridiculous’ | Trump administration

    Donald Trump called Elon Musk’s decision to start and bankroll a new US political party “ridiculous” on Sunday. “Third parties have never worked, so he can have fun with it but I think it’s ridiculous,” the president told reporters traveling with him back to the White House from his New Jersey golf club.

    He then elaborated, at great length, in a post on his social media platform, Truth Social. “I am saddened to watch Elon Musk go completely ‘off the rails,’ essentially becoming a TRAIN WRECK over the past five weeks,” the president wrote. “He even wants to start a Third Political Party, despite the fact that they have never succeeded in the United States”.

    “The one thing Third Parties are good for is the creation of Complete and Total DISRUPTION & CHAOS,” Trump added. He then went on to claim that Musk was motivated by discontent over his plan to end subsidies to promote the purchase of electric vehicles.

    Trump also accused Musk of seeking improper influence by asking the president to nominate his friend, Jared Isaacman, to be Nasa administrator. After Musk left his role as a special government employee in the Trump administration, Isaacman’s nomination was withdrawn. “I also thought it inappropriate that a very close friend of Elon, who was in the Space Business, run NASA, when NASA is such a big part of Elon’s corporate life,” Trump wrote.

    Earlier on Sunday, Trump’s treasury secretary said Musk should focus on running his companies and keep himself out of politics, a day after the world’s richest person – and a former White House adviser – announced the formation of a new political party.

    “The principles of Doge were very popular – I think if you looked at the polling Elon was not,” Scott Bessent said on CNN’s State of the Union, referring to the so-called “department of government efficiency” that Musk temporarily headed after Trump’s second presidency began in January.

    Opinion polls found Doge and Musk’s work implementing brutal spending and job cuts within the federal government to be deeply unpopular. And Bessent alluded to how investors in Musk’s companies – including the electrical vehicle maker Tesla, whose sales have suffered during Doge’s existence – publicly pleaded for his time with the Trump administration to be short-lived.

    “So I believe that the boards of directors at his various companies wanted him to come back and run those companies,” Bessent remarked. “I imagine that those boards of directors did not like this announcement yesterday, and will be encouraging him to focus on his business activities, not his political activities.”

    Bessent’s reaction came after Musk delivered on his promise to form a new party, and accused his one-time ally Trump of “bankrupting” the country by signing his massive tax and spending bill into law.

    The tech billionaire announced the creation of the America party in a series of posts late on Saturday and early Sunday to X, the social media platform he owns.

    “When it comes to bankrupting our country with waste & graft, we live in a one-party system, not a democracy,” he wrote.

    “Today, the America Party is formed to give you back your freedom.”

    Musk, who was appointed to slash federal spending through the unofficial Doge from January through May, has been a vocal critic of Trump’s “big, beautiful bill” that the non-partisan Congressional Budget Office said would increase the national deficit by $3.3tn (£2.85tn) through 2034.

    It provides substantial tax cuts for the super wealthy while slashing federal safety net welfare programs, with up to 10.6 million people losing healthcare insurance.

    The pair have feuded over its cost and impacts since Musk left the government in May, and on Friday, when Trump signed the bill into law in a Fourth of July picnic at the White House, the Tesla and SpaceX chief opened a poll on X: “the perfect time to ask if you want independence from the two-party (some would say uniparty) system”.

    Respondents voted two to one in the affirmative, Musk announced late on Saturday. He gave few details about the structure of his new venture or a timeline for its creation. But his earlier posts suggested it would focus on two or three Senate seats, and eight to 10 House districts.

    Both chambers of Congress are narrowly controlled by Republicans.

    “Given the razor-thin legislative margins, that would be enough to serve as the deciding vote on contentious laws, ensuring that they serve the true will of the people,” Musk said.

    Bessent was one Trump ally to quickly take a swipe at Musk’s move.

    Musk’s series of posts to X, which continued into the early hours of Sunday, also appeared to indicate that his on-again, off-again relationship with Trump was firmly back in negative territory.

    When the pair fell out earlier in the summer, Musk lashed out during an astonishing social media duel in which he stated Trump’s name was in the files relating to associates of the late pedophile and sex trafficker Jeffrey Epstein.

    Musk later deleted the post and apologized to the president as they embarked on an uneasy truce. On Sunday, however, Musk returned to the subject, reposting a photo of the jailed Epstein facilitator Ghislaine Maxwell that questioned why she was the only person in prison while men who engaged in sex with underage girls – a crime colloquially known in the US as statutory rape – were not.

    In other posts he said it would be “not hard” to break the two-party stranglehold in US politics enjoyed by Democrats and Republicans. And he questioned “when & where should we hold the inaugural American Party congress? This will be super fun!”

    Trump has made clear his feelings about his former friend in recent days after criticism of the bill.

    In response to Musk’s posts calling the bill “insane”, Trump said he might “look into” deporting the South African-born, naturalized US citizen billionaire. The president also mused about slashing subsidies to his companies, especially SpaceX, which holds billions of dollars in government contracts.

    “Doge is the monster that might have to go back and eat Elon. Wouldn’t that be terrible?” Trump asked reporters on Tuesday.

    There is no requirement for new political parties in the US to register with the Federal Election Commission (FEC) initially, but reporting regulations kick in once spending surpasses what the FEC calls “certain thresholds”.

    Musk is estimated to have spent more than $275m of his personal fortune helping to get Trump elected to a second term in the White House in last November’s presidential election.

    Continue Reading

  • Musk should stay out of politics, US Treasury Secretary Bessent says – Reuters

    1. Musk should stay out of politics, US Treasury Secretary Bessent says  Reuters
    2. Elon Musk says he is launching new political party  BBC
    3. Musk says he is forming new political party after fallout with Trump  CNN
    4. DOGE eats Musk? Billionaire entrepreneur’s companies at risk as he reignites feud with Trump  AP News
    5. Elon Musk launches the America Party as feud with Trump escalates  Al Jazeera

    Continue Reading

  • Daniel Brown wins with a flawless final round.

    Daniel Brown wins with a flawless final round.

    +++ England’s Daniel Brown (-22) triumphs in Munich, ahead of Jordan
    Smith (ENG) and Kazuma Kobori (NZL) +++ Matti Schmid is the best
    German in seventh, amateur Tim Wiedemeyer impresses in 17th
    place +++ € 73,000 for “Eagles for Education” and the Philipp Lahm
    Foundation +++ 58,000 golf fans flock to Golfclub München Eichenried +++



    Munich.
    Englishmen Daniel Brown and Jordan Smith,
    teeing off in the final group, began the final round with a
    spectacular flurry of birdies that delighted the crowds in Munich.
    Smith came into the Sunday one shot behind his compatriot, but
    overcame that deficit with five birdies on the first nine holes.
    Brown, for his part, hit back with four birdies. However, unlike his
    playing partner, he did not drop a single shot and was ultimately a
    worthy winner of the only DP World Tour event in Germany. The
    30-year-old carded rounds of 70, 65, 65 and 66 to end the tournament
    on 22 under par (266 shots) and claim his second title on the DP World Tour.

    “At the end of a fantastic tournament week, it is my pleasure, on
    behalf of BMW, to congratulate Daniel Brown on his deserved title at
    the 36th BMW International Open,” said Jochen Goller, Member of the
    Board of Management of BMW AG, Customer, Brands, Sales. “The
    atmosphere around the course was sensational. It was great to see so
    many fans, customers and friends of the game of golf here. We are also
    delighted with the many eagles that were carded, namely 73, meaning
    the BMW Group will donate € 73,000 to the Philipp Lahm Foundation for
    Sport and Education.”

    This year, the BMW Group donated €1,000 for every eagle scored over
    the course of the tournament to the Philipp Lahm Foundation for Sport
    and Education. The shared goal is to give children and young people
    skills and knowledge in the areas of exercise, nutrition and personal
    development. This is the third time that the BMW Group has used its
    “Eagles for Education” initiative at the BMW International Open to
    work towards equal opportunity and better prospects for children and
    young people who have a difficult start to life. The 73 eagles at this
    year’s tournament is a record for “Eagles for Education”.

    Making his 69th appearance on the DP World Tour, Brown
    became the eighth Englishman to win the iconic German tournament. In
    doing so, he followed in the footsteps of Matt Wallace (2018), Danny
    Willett (2012), David Horsey (2010), Nick Dougherty (2009), David
    Howell (2005), Lee Westwood (2003) and Russell Claydon (1998). Brown
    had his low error count to thank for the victory – over the course of
    the whole tournament, he only dropped three shots – as well as a
    nerveless final round. Smith carded three bogeys on the final nine
    holes and must consequently – as he did last year – settle for second
    place, despite having had a very good tournament.

    “It means an awful lot to me. I did not really take it all in when I
    claimed my first victory but today hit me straight away. I lost a
    friend last weekend. This is for him. All day, it felt as though I was
    not playing in my own body. I could feel the tension and then I
    started to think what it would mean to win a golf tournament like
    this. That repressed what happened a little. I believe he was with me,
    and that made it a bit easier,” said a visibly emotional Brown.

    Third place went to Japan-born New Zealander Kazuma Kobori (-18), who
    thrilled the 17,500 golf fans on Sunday with a round of 63 (9 under
    par) – the best of the week, together with Davis Bryant (USA, round
    two). A total of 58,000 visitors flocked to Golfclub München
    Eichenried over the course of the week. Bryant, Joost Luiten (NED) and
    Kristoffer Reitan (NOR all -16) ended the tournament tied in fourth place.

    The best-placed German at this year’s BMW International Open was
    Matti Schmid (-15, T7). The man from Regensburg, who predominantly
    plays in the USA on the PGA TOUR, said: “The atmosphere was more than
    mega all week. I hope everyone comes back again, as it is nice to have
    a full house here. I am obviously happy with the result, as the top
    ten is always a super outcome. My performance was mixed. On the whole,
    there was more there for me – however, I assume everyone feels that
    way. I felt very good on the greens. At some point, everything will
    come together at the same time.”

    Munich-born Tim Wiedemeyer also gave an outstanding display. He made
    the cut without any problems and ended the week as the top amateur.
    The 20-year-old did not stray above par on any of his four rounds (72,
    66, 69, 69) and finished tied in an impressive 17th place.
    Wiedemeyer said: “It was really cool. I missed out a few times, and
    could definitely have done better, but I am very happy with the
    result. I could take something from the tournament in all areas of the
    game. The walk to the 18th green on the final day was the best moment
    of the week.”

    Seven German players made it to the weekend: Martin Kaymer (-11,
    T19), Marcel Schneider (-10, T26), Marcel Siem (-4, T58), Yannik Paul
    and Hurly Long (both Even Par, T66).


    The full final result of the 36th BMW International
    Open can be found in the PDF document attached.

    Continue Reading

  • Former Arkane Studios Founder Calls Game Pass “Unsustainable”

    Former Arkane Studios Founder Calls Game Pass “Unsustainable”

    With all the backlash towards Microsoft this week, former Arkane Studios founder Raphael Colantonio has called out Game Pass as the “elephant in the room.”

    Branding it an “unsustainable model that has been increasingly damaging the industry for a decade, subsidized by Microsoft’s ‘infinite money’,” Colantonio believes that at some point “reality has to hit.” “I don’t think Game Pass can co-exist with other models, they’ll either kill everyone else or give up.”

    Responding to Michael Douse, director of publishing on Baldur’s Gate 3, who said the “infinite money thing never made any sense,” Colantonio said, “I agree, and I’m fed up with all the BS they fed us at first like ‘Don’t worry, it doesn’t impact the sales’, only to admit years later that it totally does. ‘No s*** it does! Really?’”

    Douse did highlight how it could help provide recognition for “smaller teams with new or riskier IPs,” but preferred Sony’s “lifecycle management strategy.” Colantonio responded, “The only way Game Pass can co-exist without hurting everyone is for the back catalogue.”

    While Game Pass started with much fanfare, its subscription numbers have slowed over the years. Despite this, PC Game Pass subscriptions still grew by over 30 percent in the second quarter of fiscal year 2025. Furthermore, developers like Rebellion have noted the service’s role in making its new title Atomfall a success. Pocketpair even highlighted how it’s “very worth” having your title on Game Pass after the success of Clair Obscur: Expedition 33.

    Of course, whether the shoe will drop and developers aren’t offered as lucrative deals to bring their titles to Game Pass remains to be seen. For the time being, Microsoft shows no signs of stopping its own titles from launching on day one for the service. However, Phil Spencer said the company doesn’t want it to replace the practice of owning games. Head here for more details.



    Continue Reading

  • Carlberg celebrates Junior ERC hat-trick after perfect planning

    Carlberg celebrates Junior ERC hat-trick after perfect planning

    With Jørgen Eriksen co-driving his Hankook-equipped Opel Corsa Rally4, Swede Carlberg headed into Sunday’s final leg 7.8sec in front of Peugeot-driving Sergi Pérez.

    Although the ADAC Opel Rally Junior Team driver’s path to Rally di Roma Capitale glory was eased when Pérez hit a rock in the road on SS9 and dropped out of contention, Carlberg revealed that his strategy was vital to his success on the Italian asphalt fixture.

    “The plan has always been to really try to be fast on the first loop of the first day to try to decide [the result] on the first day,” Carlberg said. “Here we took a bit longer but when you can manage for sure it’s much easier than having to push for the whole rally.

    Jasper Vaher in Junior ERC action at ERC Rally di Roma Capitale

    © At World

    “After Sergi had a problem sure it was very difficult [with a big lead] but we’ve been through this two times already, having to go slowly to make it to the finish. We were counting on how much time we could lose without being at risk and we did exactly that.

    “Exactly after the finish my brother sent me a calculation he’d done with AI to know what I need to do on the Barum Rally and it’s looking really good [for the championship] but we still have a job to do.”

    “Exactly after the finish my brother sent me a calculation he’d done with AI to know what I need to do on the Barum Rally and it’s looking really good [for the championship] but we still have a job to do.”

    After slipping back from second to ninth, Pérez was forced to retire prior to SS11 due to the damage sustained earlier in the day.

    “It was going well but in the second stage we hit a rock in the middle of the road,” Pérez said. “There was nothing to do, only bad luck, just unbelievable. We had a puncture, we damaged the rim as well and the suspension on the front left.”

    With Pérez out of luck, a thrilling battle for the final two podium places raged for much of the final day with less than 10 seconds covering positions two to five across several stages.

    Motorsport Ireland Rally Academy’s Craig Rahill snatched the final spot on the podium over Brit Ioan Lloyd

    Motorsport Ireland Rally Academy’s Craig Rahill at Rally di Roma Capitale

    © At World

    Jaspar Vaher, driving a Lancia Ypsilon Rally4 HF, eventually bagged the runner-up spot, just 3.1sec ahead of Motorsport Ireland Rally Academy’s Craig Rahill. Ioan Lloyd was a further 1.2sec back with Junior ERC rookie Yohan Surroca 4.3sec adrift of Lloyd despite a spin on the penultimate stage.

    While Vaher has been a podium visitor before in the Hankook-supplied category, it was a first top-three finish for Rahill. “I’m absolutely over the moon,” said Rahill. “It’s mad after 200 kilometres there’s only four or five seconds between third and fifth. It just shows you how tight the racing is.”

    ACI Team Italia-supported Francesco Dei Ceci finished sixth and was followed home by Tuukka Kauppinen, Keelan Grogan, Leevi Lassila, Aoife Raftery and Kevin Sariva.

    Barum Czech Rally Zlín hosts the fifth round of the Junior ERC season from 15 – 17 August. Visit FIAERC.com on Wednesday for the Junior ERC round-up.

    Continue Reading

  • How AI Is Rewriting Indie Filmmaking, As Seen By Aleksi Hyvärinen

    How AI Is Rewriting Indie Filmmaking, As Seen By Aleksi Hyvärinen

    “Some days I’m really excited about the possibilities,” says Finnish producer Aleksi Hyvärinen. “The next day, I’m like, ‘Wait, is this even a good thing?’”

    That tension, between optimism and unease, set the tone for a two-day workshop at this year’s Amman International Film Festival, where Hyvärinen led a session titled AI and Filmmaking: A Grounded Guide as part of the festival’s Amman Film Industry Days program. Hyvärinen, who co-founded The Alchemist, a Nordic creative studio combining storytelling and AI to create “emotionally intelligent” content for film, TV and branded media, guided the workshop that skipped coding and tech demos in favor of a far more nuanced goal: getting real about what AI means for the future of storytelling.

    “It turned into two days of discussion,” Hyvärinen recalls. “We didn’t dive into generating videos or learning software. That’s not where the real urgency lies. What people needed was context, grounding, and space to reflect.”

    Hyvärinen, who has produced films like “The Twin,” “Lake Bodom,” and Netflix’s “Hold Your Breath: The Ice Dive,” has hosted similar AI sessions across Europe, including in Croatia, Cyprus, Finland, the Netherlands, and, now, Jordan.

    While each group brings a different cultural backdrop, the spectrum of reactions is surprisingly consistent: “Some were ready to dive in. Some were totally skeptical. Most were like me: living in the grey zone, just trying to figure it out.”

    Yet no matter the stance, one takeaway keeps surfacing: “People leave saying, ‘I need to know more about this.’ Whether they love AI or fear it, they know it’s not going away.”

    Reactions to AI

    That urgency resonated with many in the room.

    “Before the workshop, I had a medium level of familiarity with AI tools, mostly out of curiosity,” said Anwaar Al-Shawabkeh, a Jordanian filmmaker (“Start Now”). “But those two days truly shifted my perception! After going through the tools with Aleksi, I felt it had become true and there is no way to avoid it.”

    One moment that struck her: how casually participants began referring to AI as “he.” “It made me reflect on how this technology might evolve, and how our kids may see it entirely differently. No one asked us if we wanted this change and no one will. It’s coming!”

    While she expressed some ethical concern, particularly around the lack of clear terms in creative industries, Al-Shawabkeh ultimately sees AI as a natural next step. “As happened 50 years ago in red editing rooms, what used to take hours will soon be done with one click. I plan to use AI in my future work. With careful thought and experience, I believe it will enhance the creative process in powerful ways.”

    Her main takeaway for fellow indie filmmakers? “Don’t panic. AI is just a new tool. We need to explore both its strengths and limitations to truly understand its place in our work, and in the world to come.”

    Mohammed AlQaq, Aleksi Hyvärinen, Anwaar Al-Shawabkeh
    Courtesy of Mohammed AlQaq, Aleksi Hyvärinen, Anwaar Al-Shawabkeh

    How AI Is Reshaping Workflow

    One of the workshop’s central goals was to demystify how AI is actually being used in filmmaking and to draw a sharp line between what’s possible now and what remains hype.

    Participants explored tools like Google Veo and Google Flow, as well as 4D Gaussian Splatting, an astonishing new method that allows filmmakers to create 3D environments from just a few flat images. “You can shoot a simple 2D scene,” Hyvärinen explains, “and later reframe it, change the camera angle, zoom in. It becomes a full 3D model.”

    But it wasn’t just the flashy stuff. A significant part of the workshop focused on non-generative AI, tools that don’t create new media but help organize and accelerate existing workflows. Think AI for de-rushing 300 hours of raw documentary footage, automatically cataloging dialogue and scenes.

    “It’s often overlooked in the ethical conversation,” he says. “While non-generative AI tools aren’t free from ethical or copyright concerns, they typically don’t carry the same weight or creative implications as generative AI.”

    Still, he’s realistic. Entry-level jobs, like assistant editors, may be among the first to go. “It’s not necessarily better, it’s just cheaper and faster. And that’s usually how the world works.”

    That question of authorship also resonated with participants, especially around the issue of control.

    “Before the workshop, I thought I completely rejected the idea of AI taking the place of my mind or my creativity,” said Mohammed AlQaq, Palestinian-Jordanian artist, performer, and filmmaker. “I wanted to use it only to save time, but not to save my creativity.”

    But by the end of the two days, his stance had shifted slightly. “I still hold that opinion, but I’ve also changed. I realized that even in creative work, I can still be in control.”

    AlQaq pushed back on one participant who expressed fear about AI’s role in filmmaking: “I felt that discussion was a bit dramatic. There’s no need to be afraid. This is a tool, not a threat.”

    Still, concerns remain. “I’ll continue to have concerns about copyright, and I’ll always have questions filled with fear: Will I truly own all the rights? Will these tools one day deceive me and say I have to pay huge sums to obtain them?”

    His takeaway? “AI is just another tool, an assistant, and I will always be the director.”

    AI: A Cost-Cutter When the Industry Faces Budget Constraints

    When asked where he draws the line between assistance and authorship, Hyvärinen cites a fellow Finnish writer, Katri Manninen, who compares AI to having a human assistant in a Hollywood writers’ room.

    “If you’d credit a human for that level of input, then AI shouldn’t be doing it either,” he says emphatically. “You can’t let it cross that creative line.”

    That said, he uses it often as a brainstorming partner. “It’s amazing at surfacing ideas quickly. But once you dig in, you see it’s generic. There’s no voice. No point of view. Storytelling is all about point of view.”

    Coming from Finland, Hyvärinen is no stranger to budget constraints. That’s why he believes indie filmmakers might have the most to gain, as long as they approach AI strategically.

    “There are stories we never even pitched because we knew we couldn’t afford them,” he says. “Now? Maybe we can. Maybe we don’t need $10 million. Maybe we can make it for $500K and still pull it off.”

    What does Hyvärinen imagine the industry will look like in 2029? He envisions a split: high-end, handcrafted cinema on one end, and fast-turnaround, AI-enhanced content, think telenovelas or streaming serials, on the other. “We might be shooting actors in green screen studios, generating environments, tweaking wardrobe, faces, dialogue, even camera angles. All of that in post-production.”

    Still, he believes core creative work will remain human, particularly acting, direction, and story. “But the rest? Location scouting, production design, maybe even some editing, that’s going to shift.”

    And while he compares the shift to past transformations like digital cinematography, nonlinear editing, and the rise of the Internet, he’s under no illusion that this will be a smooth ride.

    “It’s going to be partly great and partly painful. Like the internet in the 2000s, or electricity in the early 1900s, we can guess a few things, but we have no idea what’s really coming.”

    Continue Reading

  • mFOLFIRINOX Does Not Significantly Improve Survival Vs mFOLFOX6 in HER2– Metastatic Gastric/GEJ Adenocarcinoma

    mFOLFIRINOX Does Not Significantly Improve Survival Vs mFOLFOX6 in HER2– Metastatic Gastric/GEJ Adenocarcinoma

    mFOLFIRINOX vs mFOLFOX6 in Gastric/GEJ
    Cancer | Image Credit: © Ashling Wahner &
    MJH Life Sciences Using AI

    mFOLFIRINOX (irinotecan plus oxaliplatin, leucovorin, and fluorouracil [5-FU]) significantly improved objective response rate (ORR) but not progression-free survival (PFS) or overall survival (OS) vs mFOLFOX6 (oxaliplatin, leucovorin, and 5-FU) in patients when used as a frontline treatment of patients with HER2-negative metastatic gastric and gastroesophageal adenocarcinoma, according to data from the phase 3 IRIGA trial (NCT04442984) presented at the 2025 ESMO Gastrointestinal Cancers Congress.1

    The median PFS was numerically improved with mFOLFIRINOX (triplet; n = 157) vs mFOLFOX6 (doublet; n = 161), at 7.20 months (95% CI, 6.82-7.58) and 6.83 months (95% CI, 5.76-7.90), respectively (HR, 0.81; 95% CI, 0.63-1.04; P = .266). However, a significant improvement was observed in those with grade 1 or 2 disease, at a median of 9.9 months (95% CI, 5.6-14.2) vs 8.4 months (95% CI, 7.5-9.2), respectively (HR, 0.55; 95% CI, 0.30-0.99). The median OS with mFOLFIRINOX vs mFOLFOX6 was 13.40 months (95% CI, 11.76-15.04) and 13.23 months (95% CI, 10.86-15.60; HR, 0.87; 95% CI, 0.66-1.15; P = .322).

    The partial response rates in the mFOLFIRINOX and mFOLFOX6 arms were 31.2% vs 19.3% (P = .014), the stable disease rates were 43.3% vs 47.8% (P = .419), disease control rates were 74.5% vs 67.1% (P = .144), and the progressive disease rates were 20.4% vs 31.7% (P = .022); 4.5% and 1.2% of patients in the respective arms were not evaluable for response.

    “Despite improved response, no significant benefit in OS or PFS was observed in the overall population. A significant improvement in PFS was seen in patients with grade 1 or grade 2 gastric adenocarcinoma treated with mFOLFIRINOX,” Daria Gavrilova, MD, of Russian Federation, said in a presentation of the data. “mFOLFIRINOX was associated with a higher incidence of treatment-related toxicities.”

    A Spotlight on IRIGA

    The single-center, open-label, randomized phase 3 study enrolled patients with advanced gastric or gastroesophageal HER2-negative adenocarcinoma who had an ECOG performance status of 0 to 2 and who had not previously received systemic therapy for advanced disease. Adjuvant therapy was permitted if received longer than 6 months before the study.

    Study participants were randomly assigned 1:1 to mFOLFIRINOX vs mFOLFOX6. Those in the mFOLFIRINOX arm received 180 mg/m2 of irinotecan, 85 mg/m2 of oxaliplatin, 200 mg/m2 of leucovorin, and 250 mg/m2 of 5-FU plus 2200 mg/m2 every 2 weeks. Those in the mFOLFOX6 arm received 85 mg/m2, 400 mg/m2 of leucovorin, and 400 mg/m2 of 5-FU plus 2400 mg/m2 every 2 weeks. Patients received 9 cycles of chemotherapy and then underwent observation. They did not receive maintenance treatment.

    Patients were stratified based on age (under 65 years vs 65 years or older), primary tumor (present vs resected), histological differentiation (G1 to G2 vs G3 to signet ring cell carcinoma), number of metastatic sites (1 to 2 vs 3 or more), tumor location (gastroesophageal junction vs stomach), and ECOG performance status (0 to 1 vs 2).

    The primary end point of the study was PFS, and secondary end points included OS, ORR, toxicity, efficacy across Lauren subtypes, and efficacy by tumor grade. Investigators also sought to detect a hazard ratio of 0.73 with 82% power, 1-sided α = 0.05, and a 10% dropout rate, which translates to 163 patients per group.

    A total of 326 patients were enrolled in the study, and the median follow-up was 22.4 months. The median patient age was 57 years (range, 20-75) with mFOLFIRINOX vs 58 years (range, 34-74) with mFOLFOX6, with 24.2% and 29.8% of patients aged 65 years or older. Slightly more than half of the patients were male (57.3% vs 55.3%). Most patients had an ECOG performance status of 1 (87.9% vs 83.2%), had a primary tumor site of the stomach (87.3% vs 85.7%), histological grade 3 plus signet-ring cell (78.9% vs 72.1%), and 1 to 2 metastatic sites (73.2% vs 75.8%). Moreover, 5.7% and 7.5% of those in the mFOLFIRINOX and mFOLFOX6 arms had prior primary tumor resection.

    Additional Subgroup Analysis Data

    The hazard ratio (HR) for PFS in women was 0.83 (95% CI, 0.59-1.16) and 0.79 (95% CI, 0.55-1.16) in men. In those under 65 years, the HR for PFS was 0.77 (95% CI, 0.58-1.03); in those aged 65 years or older, the HR for PFS was 0.79 (95% CI, 0.46-1.36). In those with an ECOG performance status of 0 to 1 or 2, the HRs for PFS were 0.81 (95% CI, 0.63-1.05) and 0.83 (95% CI, 0.25-2.79), respectively. In those with histological grade 3 plus signet ring cell disease, the HR for PFS was 0.83 (95% CI, 0.62-1.10). In those with GEJ or stomach cancer, the HRs for PFS were 0.90 (95% CI, 0.46-1.79) and 0.79 (95% CI, 0.60-1.04), respectively.

    Moreover, in those with Lauren classifications of intestinal, diffuse, or mixed, the respective HRS for PFS were 0.78 (95% CI, 0.50-1.22), 0.72 (95% CI, 0.49-1.04), and 0.99 (95% CI, 0.58-1.69). In those with no more than 2 organs with metastases, the HR for PFS was 0.81 (95% CI, 0.60-1.08); in those with 3 or more organs with metastases, the HR for PFS was 0.73 (95% CI, 0.45-1.19). The HRs for PFS in those who had prior tumor resection vs those who did not were 0.69 (95% CI, 0.24-1.92) and 0.79 (95% CI, 0.61-1.02).

    Safety Revelations

    The most common grade 1 to 2 adverse effects (AEs) reported in the mFOLFIRINOX and mFOLFOX6 arms were asthenia (88.1% vs 87.4%; P = .736), nausea (41.4% vs 24.5%; P = .001), diarrhea (40% vs 10.1%; P < .001), hepatotoxicity (36.6% vs 31.5%; P = .333), thrombocytopenia (25.3% vs 24.5%; P = .869), neutropenia (23.3% vs 23.6%; P = .907), peripheral neuropathy (18.7% vs 20.1%; P = .746), vomiting (16% vs 3.8%; P < .001), mucositis (7.3% vs 2.5%; P = .069). The most common grade 3 or 4 AEs in the respective arms were neutropenia (38.7% vs 26.4%; P = .280), asthenia (6.6% vs 0.6%; P = .019), febrile neutropenia (4% vs 1.3%; P = .168), thrombocytopenia (2.7% vs 1.3%; P = .439), diarrhea (2.7% vs 0% P = .057), nausea (1.3% vs 0%; P = .238), hepatotoxicity (0.7% vs 0.6%; P = 1.000), and vomiting (0.7% vs 0%; P = .487).

    Disclosures: All authors have declared no conflicts of interest.

    Reference

    Gavrilova D, Besova N, Obarevich E, et al. IRIGA: Phase III randomized trial of mFOLFIRINOX versus mFOLFOX6 as first-line treatment for HER2-negative metastatic gastric and gastroesophageal adenocarcinoma. Presented at: 2025 ESMO Gastrointestinal Cancers Congress; July 2-5, 2025; Barcelona, Spain. Abstract 391MO.

    Continue Reading

  • Air India Express Ignored Directive Ordering Airbus A320 Engine Part Change & Falsified Records

    Air India Express Ignored Directive Ordering Airbus A320 Engine Part Change & Falsified Records

    Air India Express reportedly ignored a directive from the European Union Aviation Safety Agency (EASA) to replace engine parts on its Airbus A320 aircraft and falsified documents to show compliance, according to a report by Reuters. The issue was raised in March 2025, several months before Air India’s fatal Boeing 787-8 Dreamliner crash.

    In response, India’s aviation regulator, the DGCA, reprimanded Air India’s budget carrier, according to a confidential government memo reviewed by Reuters. Following the report, Air India Express told the publication it had acknowledged the error to the regulator and taken “remedial action and preventive measures.”

    Modifications Were Required On VT-ATD

    Photo: Kowshi .L | Shutterstock

    In 2023, EASA issued Airworthiness Directive 2023-0108 for CFM International LEAP-1A engines, requiring the replacement of specific components. The directive was based on a manufacturer’s investigation that found some parts, including high-pressure turbine (HPT) stage 1 disks, forward outer seals, and compressor rotor stages 6–10 spools, may have been made from material with reduced strength due to iron contamination.

    The confidential memo from the Indian government, sent to the budget airline in March 2025 and reviewed by Reuters, stated that DGCA surveillance found the required engine modification on an Air India Express Airbus A320neo, registered as VT-ATD, had not been completed within the specified deadline. Adding to that, the memo said that “in order to show that the work has been carried out within the prescribed limits, the AMOS records have apparently been altered/forged.”

    The airline’s VT-ATD is a five-year-old narrowbody aircraft leased from AerCap. It has been flying in Air India Express livery since 2023, after previously being operated by AIX Connect (it merged with Air India Express in 2024), according to ch-aviation data. As of September 30, 2023, the aircraft has clocked in a total of 14,159 flight hours and 6,930 flight cycles.

    Air India Crash Prompts Scrutiny On Indian Aviation Safety

    Air India Boeing 787-8 at SIN shutterstock_2355149121

    Photo: Markus Mainka | Shutterstock

    Indian aviation safety came under intense scrutiny after the tragic crash of Air India’s Boeing 787-8 Dreamliner on June 12, 2025, which claimed 241 of the 242 lives on board. In the most recent news, India’s upper house of parliament has proposed a comprehensive safety review of the country’s civil aviation sector. Reuters reviewed a draft memo, which stated that airport operators, air traffic controllers, and airlines, including Air India and IndiGo, have been asked to participate in the review to improve safety standards.

    Additionally, Western aviation regulators in the United States, the United Kingdom, and France have reportedly raised concerns about the transparency of the Boeing 787 Dreamliner crash investigation being led by Indian authorities. According to two sources familiar with the matter, who spoke to Corriere della Sera, there are behind-the-scenes fears that local political pressures could influence the investigation and its final report.

    The concerns arose following the handling of the two black boxes, which were not sent to the United States or France, despite both countries’ recognized expertise in this area. Adding to this was the recent rejection of ICAO observers from participating in the investigation.

    Related

    Aviation Safety Under Government Review Following Air India Crash

    Tomorrow will mark three weeks since an Air India Boeing 787 crashed in Ahmedabad.

    More About Air India Express

    Air India Express Boeing 737 MAX

    Photo: Air India Express

    Founded in 2005, Air India Express is a low-cost arm of Air India, which is owned by the Tata Group. The Tata Group officially took over Air India in 2022. The takeover raised hopes that Tata’s business acumen would help make Air India and its low-cost subsidiary Air India Express become “a world-class” carrier.

    The low-cost airline operates a fleet of 114 aircraft, according to ch-aviation. The fleet includes 49 Boeing 737 MAX 8s, 26 Boeing 737-800s, 24 Airbus A320-200s, 12 Airbus A320neos, and three Airbus A321neo narrowbodies. Looking ahead, the airline is awaiting deliveries of 50 Boeing 737 MAX 10s and 91 Boeing 737 MAX 8s, as per ch-aviation.


    Air India

    Year Founded

    1946

    CEO

    Campbell Wilson



    Air India Express operates flights to over 50 destinations, serving both international and domestic markets. Its route network spans across Asia-Pacific, the Middle East, and various cities within India.

    Continue Reading

  • New memristor-based system from China boosts AI data sorting efficiency

    New memristor-based system from China boosts AI data sorting efficiency

    In a bid to overcome shortcomings in scientific computing, Chinese scientists have unveiled a new approach to sorting data that promises both higher speed and lower energy consumption. The system combines memristors—electronic components that mimic the memory function of the human brain—with an advanced sorting algorithm to process large amounts of information more efficiently. 

    Researchers say this method could help overcome performance bottlenecks in not just computing but also artificial intelligence (AI), and hardware design, where rapidly organizing and analyzing vast datasets is essential. Beyond AI, potential applications for this technology include smart traffic systems that analyze images in real time and financial services that require quick risk assessments.

    Prototype shows memristor sorting boosts route finding and neural inference

    To demonstrate the potential of their technology, scientists from Peking University and the Chinese Institute for Brain Research created a hardware sorting prototype based on memristors. The system successfully handled tasks like route finding and neural network inference, delivering faster performance and lower energy consumption compared to traditional sorting methods, the South China Morning Post reported.

    Overall, the system achieved a 7.7-fold increase in throughput and improved energy efficiency by more than 160 times compared to conventional sorting methods. It also boosted area efficiency by over 32 times, marking a significant step towards integrating storage and computing for broader, general-purpose applications.

    In a paper published in Nature Electronics last month, the team explained that sorting remains a major performance limitation across applications ranging from artificial intelligence and databases to web search and scientific computing.

    Traditional computing systems rely on the Von Neumann architecture, which separates data storage and processing functions, typically using a central processing unit (CPU) to handle calculations.

    New insights into memristors show potential to revolutionize computing

    According to the researchers of the latest study, the conventional system has led to the Von Neumann bottleneck, which limits the speed of data transfer between memory and processing units. They explained that while sort-in-memory approaches using memristors could help overcome these limitations, current systems still depend on comparison operations, keeping sorting performance constrained.

    Unlike ordinary resistors, which simply reduce the flow of electricity in a circuit, memristors have the unique ability to remember how much electrical charge has passed through them. This memory function allows memristors to adjust their resistance based on previous activity, enabling them to act as both storage and processing components. 

    By combining these functions, memristors could eliminate the need to transfer data between separate memory and processing units, potentially leading to faster and more energy-efficient computing systems.

    The scientific team aimed to simplify sorting by removing the need for comparison units. Traditional hardware sorting relies on CPUs, GPUs, or specialised chips that compare numbers step by step using sorting algorithms. Instead, the new method uses memristors to perform iterative search-based sorting, finding minimum or maximum values without directly comparing each pair, which in turn saves both time and energy.

    Continue Reading

  • The CHALLENGE Trial Helps Redefine Adjuvant Therapy with Exercise in CRC

    The CHALLENGE Trial Helps Redefine Adjuvant Therapy with Exercise in CRC

    Nicholas James Hornstein, MD, PhD, discussed results from the phase 3 CHALLENGE trial (NCT00819208) that were presented at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting. According to Hornstein, this trial has garnered significant attention, particularly for its exploration of exercise as a therapeutic intervention in colorectal cancer.

    This randomized study enrolled patients who had undergone resection for localized colon cancer and assigned them to 1 of 2 arms: a regimented exercise program with a personal trainer or an educational arm providing general advice on the benefits of exercise.

    Hornstein, an assistant professor at the Donald and Barbara Zucker School of Medicine of Hofstra University and Northwell Health, noted that the study yielded remarkably positive results. The disease-free survival (DFS) in the group that participated in the structured exercise intervention was substantially higher. The observed DFS benefit from exercise was, according to Hornstein, surprisingly even greater than that seen with oxaliplatin chemotherapy, a standard component of adjuvant treatment for colorectal cancer.

    Transcript:

    This was not a plenary session. This was an oral [session], and this study has gotten a lot of press. I’ve heard the saying, exercise is the best medicine, and this was explored in the clinical trial. This was a randomized trial taking patients who were status post-resection for localized colon cancer, and it put them into 2 buckets. One, you get a personal trainer and regimented exercise over the course of a week. The other was that you got [educated] about exercise. Somebody sat down and said, “Hey, exercise is great. You should think about it.” [They’re] very different interventions. A lot of people would have expected that this wouldn’t be that positive of a study, but when they randomized the data, the DFS in the group that did exercise as their intervention was drastically higher.

    Comparing this with what we normally get, things like oxaliplatin and chemotherapy, there was a higher DFS benefit with exercise than there was with oxaliplatin. This is shocking in terms of the degree of benefit that was observed in this study. Most people would have said, “Oh, yeah, there probably is going to be some benefit to exercise”, but the fact that this is looking to be on the same level as one of our chemotherapy moieties is incredible. This was an interesting study. It is something that I am discussing with all my patients now in the adjuvant setting. I’ve even had some patients who have said, “Hey, can you write me a prescription for a gym pass membership? Can you see if we can get this covered?”, because, to them and me, this is something that needs to be incorporated into our daily practice now, and a lot of patients can benefit. It’s just nice to have a study to point to and say, “Exercise is worth it.”

    Reference

    Booth CM, Vardy JL, O’Callaghan CJ, et al. A randomized phase III trial of the impact of a structured exercise program on disease-free survival (DFS) in stage 3 or high-risk stage 2 colon cancer: Canadian Cancer Trials Group (CCTG) CO.21 (CHALLENGE). J Clin Oncol. 2025;43(17):LBA3510. doi:10.1200/JCO.2025.43.17_suppl.LBA3510

    Continue Reading