- How Majchrzak’s wife-turned-trainer is fuelling his historic Wimbledon journey ATP Tour
- Wimbledon Day 1 Men’s Predictions Including Matteo Berrettini vs Kamil Majchrzak Last Word On Sports
- World No. 109 emerges as Wimbledon’s breakout star: Stuns 3 higher-ranked players and credits wife for success Bolavip
- Tennis: Poland’s Majchrzak stuns Italy’s Berrettini at Wimbledon podcasty.polskieradio.pl
- Berrettini vs. Majchrzak Prediction at the Wimbledon – Monday, June 30 Bleacher Nation
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How Majchrzak’s wife-turned-trainer is fuelling his historic Wimbledon journey – ATP Tour
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British and Irish Lions 2025: Talking points after win over the Waratahs
The power of Owen Farrell is something to behold. When the cameras panned to him at the Allianz on Saturday, the entire crowd reacted, some with pantomime booing, others with cheering. The one thing they weren’t was indifferent.
Farrell, who arrived in Sydney on Friday, took it well, smiling and laughing. The guy is pure box office. We’re all still talking about why he’s been parachuted into this squad. The coach’s son, yes, fine, we get it. But what else is going on here?
Some observers say that this was always going to happen and that Farrell will definitely be in the Test 23 for Brisbane. They’re convinced of it. The intrigue is fantastic.
His father’s official explanation in midweek is that he felt his squad was a little short at inside centre with Sione Tuipulotu and Bundee Aki the only options. Terrific ones, in fairness.
Is there more to it? Does he have doubts about Fin Smith’s readiness to back up Finn Russell on the bench? Does he have issues around the leadership of the squad – is everyone too nice and/or too quiet?
If those are views he shares, then Saturday might have only reinforced them. Smith struggled in running the backline and the direction of the team was all over the place for most of the evening.
So, enter Faz Jnr, but when? Not on Wednesday against the Brumbies, says his father. He might still be getting over the jet-lag.
Next Saturday in Adelaide against the invitational Australia-New Zealand team? All things being equal, definitely.
What about after that? If you believe that Owen can step into a Lions Test match squad (covering 10 and maybe 12) after not playing in nine weeks, having not played particularly well before that and having not featured in an international game for 20 months, then you’re convinced that he can return to his best stuff at the mere sight of the red jersey, as if the last year doesn’t matter.
Maybe he can. And maybe he will be given the chance for a fairytale tour, but the stakes are monstrously high. Smith’s struggles made Owen’s elevation a bit more likely. But will he be any good?
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Daniel Brown leads ahead of final round – Schmid and Wiedemeyer best Germans.
+++ England’s Daniel Brown (-16) takes the lead +++ Jordan Smith
(ENG, -15) in second place +++ Matti Schmid (-10, T12) and amateur Tim
Wiedemeyer (-9, T17) best Germans +++ Marcel Siem and Martin Kaymer
out of title contention +++ €56,000 already raised for “Eagles
for Education” +++
Munich. “Moving Day” under the best conditions: Round
3 of the BMW International Open shook up the leaderboard
significantly. Rising all the way to the top was England’s Daniel
Brown, who carded a 65 on Saturday to take the lead at 16 under par.
His round of 65 was the best score of the day, matched by Dutchman
Joost Luiten (-13, 3rd) and Spain’s Ivan Cantero (-11, T9). Just one
stroke behind Brown is fellow Englishman, Jordan Smith (-15), who shot
a 66.From a German perspective, the biggest movers were Matti
Schmid
(-10, T12) and amateur Tim Wiedemeyer (-9, T17). Marcel
Schneider (today -2, total -8, T20), Martin Kaymer (-2, -6, T34),
Yannik Paul (-1, -5, T41), Marcel Siem (+2, -5, T41), and Hurly Long
(-1, -4, T53) were unable to improve their positions.Brown made just one bogey on Saturday and claimed the top spot on the
leaderboard thanks to a fantastic back nine featuring four birdies and
one eagle. The 30-year-old, who celebrated his only win on the DP
World Tour in 2023, credited his performance to a sense of ease: “I
actually didn’t play or control the ball as well as I did yesterday,
but the final holes went really well. I was just in a flow, felt no
pressure all day, was very relaxed, and had fun with my caddie.”The largest deficit ever overcome by a BMW International Open winner
on Sunday is five shots – a feat achieved by five players since the
tournament began in 1989: Mark McNulty (IRL, 1994), Frank Nobilo (NZL,
1995), David Horsey (ENG, 2010), Fabrizio Zanotti (PAR, 2014), and,
most recently, Pablo Larrazábal (ESP, 2015).Although Matti Schmid posted the best round among the German players
with a 68, the Regensburg native remains six shots behind Brown – just
outside the comeback “window.” Two late bogeys on holes 16 and 17 kept
him from scoring even lower in an otherwise flawless round. Still, the
27-year-old was thrilled with the atmosphere on course and hasn’t
given up hope: “There are so many golf fans out here creating an
incredible level of support. You can only draw energy from an
atmosphere like this. Every good shot is cheered. It definitely gives
you a positive feeling. On the front nine I hit almost nothing and had
a lot of bad drives. But I had a great short game and putted well. The
back nine was really solid. Overall, I’m happy with that. You really
have to hit good shots here to score well. But with the par-5s and
hole 16, which is attackable, there are birdie chances out there.
Martin Kaymer shot 8 under in the final round back in 2021 – something
like that is what we’ll need.”Amateur Tim Wiedemeyer continued to impress. In his hometown, the
20-year-old shot a 69 and now sits at 9 under par, maintaining his
spot inside the top 20. “The atmosphere out there was great,”
Wiedemeyer said. “There were a lot of people I know in the crowd. It’s
just a cool vibe, and the support really helps you play well. After
making the cut, everything was pretty relaxed anyway. I mean, I’ve got
nothing to lose here. I know where I stand – I’m still an amateur.
I’m just having fun, learning a few things, and we’ll see what happens tomorrow.”Martin Kaymer – still the only German winner of the BMW International
Open since 2008 and the youngest in tournament history – likely won’t
add a second title this year, but was still satisfied with his
performance in Munich: “Two under par is okay, but it doesn’t get you
anywhere,” said the two-time major champion. “You really need one low
round in this tournament to climb the leaderboard. I didn’t hit enough
fairways today. If I do tomorrow, I can create a lot of chances. I
might play a bit more aggressively. I feel good around the greens and
have had lots of up-and-downs this week. So I think I can allow myself
to take a few more risks.”Marcel Siem, who had put himself in a strong weekend position after
the first two rounds, experienced what he described as “a day to
forget.” Two bogeys at the start and a triple-bogey on the par-5 6th
derailed his round early. A spectacular eagle on the par-4 16th and a
birdie on the final hole couldn’t salvage the day. “Of course it’s
frustrating and sad to know you have no chance to win anymore,” Siem
said. “Then I tried to make the impossible possible and just focused
on eagles and aces to somehow get back into it for Sunday. But it is
what it is – I’ve only got myself to blame.”Siem’s eagle was one of 56 made so far in the tournament. That means
the “Eagles for Education” donation total from last year (€55,000) has
already been surpassed in Round 3. For every eagle made during the
tournament rounds, the BMW Group donates €1,000 to the Philipp Lahm
Foundation for Sport and Education. The shared goal is to equip
children and young people with key skills in movement, nutrition, and
personal development.The final round at Golfclub München Eichenried begins on Sunday at
7:10 AM. The final pairing, featuring Brown and Smith, tees off at
1:10 PM. Please refer to the attachment for the full list of tee times.Continue Reading
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Hideo Kojima Has Space-Faring Ambitions and a Case of “Tom Cruise Disease”
Hideo Kojima lives on the edge. The legendary game designer’s works abandon safer, traditional tropes in favor of contemplative, post-modern sagas that marry AAA budgets with eccentric themes and characters, which, by his own admission, only he truly understands. He balances this singular vision against the tumultuous nature of the games industry, where experimental releases and defiant studios are shuttered without ceremony. That alone would be enough risk-taking for most creators, but Kojima is eager for more.
The iconic game maker was on the ‘World Strand’ tour, connecting with admirers across the globe, mirroring the Chiral Network from his latest opus— Death Stranding: On The Beach. The tour gives fans a chance to peer behind the messianic mythos and learn more about the humans behind Hideo. It also doubles as a well-deserved victory lap for the highly acclaimed Death Stranding 2 (review), which left us in awe with its uncompromising and soulful mastery.
Attendees at the Sydney Film Festival received a similar opportunity back in June, when Kojima appeared for a conversation alongside his “sensei,” George Miller. As relayed by The Guardian, the 61-year-old touched on topics ranging from his love for the land down under’s wildlife to his struggles with isolation during the pandemic.
Kojima also shared his dreams of charting new frontiers by visiting outer space, but not as part of some commercialized, corporate endeavor facilitated by the mushrooming space tourism sector.
“That’s not space,” he remarked. “I want to train properly, learn how to do the docking, go to the International Space Station, and stay there for a few months. I’m not a scientist, but I could probably make games in space. I want to be the first. There are a lot of astronauts over 60, so I guess it’s possible.” He joked that the absence of gravity could alleviate his nagging back pain before sharing one of his more audacious desires.
The video game auteur wants to experience a life-threatening situation and the jolt of adrenaline that comes with it. He labeled it the “Tom Cruise disease,” as a nod to another uncompromising creative who “finds out his worth when living with his life on the line.” That invigorating feeling might just be what he’s attempting to capture in OD, the mysterious horror game in development alongside Xbox.
As always, it will be fascinating to see what Hideo Kojima does next. But what are your hopes for his next project? Let us know in the comments.
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Muharram 9 processions conclude amid tight security in major cities
Listen to article Major cities across the country, including Karachi, Lahore and Peshawar, observed Muharram 9 processions on Saturday under tight security, with mobile phone services suspended in some areas and key locations sealed amid fears of unrest.
Authorities in Karachi, Lahore and Peshawar deployed tens of thousands of police personnel, sealed sensitive areas, and partially suspended mobile phone services in efforts to prevent any untoward incidents, Express News reported.
In Karachi, the main Muharram 9 procession began at 1:00 PM from Nishtar Park. Prior to the procession, a majlis was held at Nishtar Park, where Allama Shahenshah Hussain Naqvi delivered a sermon. After the majlis, the Imamia Students Organisation led the congregational Zuhrain prayers.
The procession followed its traditional route—passing through Numaish, Saddar, Radio Pakistan, Jamia Cloth, and Denso Hall—before concluding at the Hussainia Iranian Imambargah in Kharadar.
In Lahore, the main procession commenced at 10:00 am. Punjab Police spokespersons reported more than 147,000 officers and staff were stationed throughout the province to secure 1,689 processions and nearly 3,900 majalis (religious gatherings). In Lahore alone, 79 processions and 378 majalis are being protected by more than 10,000 officers.
Special instructions have been issued to the Dolphin Squad and Police Response Unit (PRU). All teams are maintaining constant coordination with Rescue 1122, the fire brigade, Rescue 15, and other emergency services. Special attention is being paid to the safety of women and children.
Read: Karachi traffic plan for Muharram processions
“The entire province is on high alert,” said Punjab Police Inspector General Dr Usman Anwar. “We’re strictly enforcing Section 144 and the Loudspeaker Act.”
In Peshawar, the main procession began at 10:00 am from Husainia Hall. The Saddar and Cantonment areas of Peshawar have been completely sealed off, and commercial centres were closed.
Due to security concerns, mobile phone services suspended for Muharram 9 and 10. The city’s Bus Rapid Transit (BRT) service has also been halted for two days.
Meanwhile, over 10,000 police and security personnel have been deployed in Peshawar, while entry of Afghan refugees into the city has been banned for two days. Several major roads, including Qissa Khwani Bazaar, Khyber Bazaar, Circular Road, and GT Road have been closed.
Muharram processions held in twin cities under tight security
The main Muharram 9 procession in Rawalpindi commenced from Imambargah Fatimiyah Chitian Hattian and concluded after passing through its designated route.
All roads adjacent to the procession route were sealed, while commercial activity remained suspended in Landa Bazaar, Iqbal Road, College Road, and Bohar Bazaar.
In Islamabad, the central Muharram 9 procession emerged from Imambargah Jamia Al-Asna Ashari, G-6 and concluded after returning to Imambargah Jamia Al-Asna Ashari via the same prescribed path.
Deputy Commissioner Islamabad Irfan Memon, speaking outside Imambargah Asna Ashari, said all arrangements for majalis and processions had been finalized weeks in advance.
Additional sanitation workers were deployed and drainage measures taken to handle last night’s rainfall. A mobile control room has been established for the first time, and street lighting issues along the route have been resolved.
محرم الحرام کے دوران سیکیورٹی کی مؤثر نگرانی کے لیے اسلام آباد پولیس کا اہم اقدام۔ جدید موبائل کنٹرول روم قائم۔
آئی جی اسلام آباد سید علی ناصر رضوی اور چیف کمشنر علی رندھاوا نے موقع پر موجود رہ کر ڈیوٹی پوائنٹس، سیف سٹی کیمروں اور ڈرون سرویلنس کے ذریعے سیکیورٹی انتظامات کا… pic.twitter.com/2q2mThH2rX
— Islamabad Police (@ICT_Police) July 5, 2025
DIG Islamabad Jawad Tariq said over 5,000 personnel from Islamabad Police and Rangers have been deployed. Multiple layers of checks are in place, with CTD commandos stationed on rooftops. Surveillance is being carried out using body cameras and modern monitoring tools.
Read more: Section 144 to remain in place across Punjab during Muharram
Inspector General of Police Islamabad Syed Ali Nasir Rizvi said extraordinary security measures were essential despite the absence of specific threats, citing the religious importance and sensitivity of Muharram. The entire route has been sealed with containers and barbed wire.
Photo: Islamabad Police- @ICT_Police/X
Photo: Islamabad Police- @ICT_Police/X
According to the IG, security personnel have shown dedication over the past eight days, and the full schedule of the procession will be followed strictly.
Speaking to the media during the procession, IG Rizvi said the event is being monitored through surveillance cameras. Covering a distance of 3.88 kilometers, the procession will return to its starting point. Police will remain on duty until its conclusion.
A total of 4,100 officers have been deployed directly for the procession, with overall security personnel reaching 5,800, including those assigned to traffic and rooftop surveillance.
A seven-layer security plan has been implemented to ensure peace and public safety. 71 search-and-sweep operations were conducted in the 14 days leading up to Muharram, stated police spokesperson.
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Jett Lawrence wins RedBud Moto 1, Eli Tomac retires with mechanical issues
Jett Lawrence scored his 37th moto win in the RedBud Nationals in Buchanan, Michigan, to stretch his championship points advantage. Jett finished more than seconds ahead of the field for the third consecutive moto.
“It was good to battle with HJ,” Jett said, referencing his brother Hunter Lawrenc. “He was running well. It was hard to pass because it was so deep. I think we went back and forth like four times in that one lap.”
The championship battle took a dramatic turn just past the halfway mark of Moto 1 of the RedBud Nationals in Buchanan, Michigan. As Jett Lawrence led the field in yet another race, Eli Tomac’s bike began to smoke. It did not take long for the bike to expire at the lowest point on the track, far away from the pits. Tomac took the long walk back and failed to earn any points for the moto. The same thing happened to him in 20189 and he was barely able to recover and finish ninth in the second race that season.
Jett had a sketchy moment early in the moto and almost crashed as he made a pass for second around RJ Hampshire.
After losing contact with his brother and with no pressure from behind, Hunter Lawrence settled into a safe ace pace and dropped back more than 15 seconds to finish second.
“It was a good race,” Hunter said. Gave Jett a run for his money in those first few laps. Just couldn’t quite get going in those later stages and we’ll go back, regroup and get ready for the next moto.”
Tomac’s departure opened the opportunity for another rider to stand on the podium as RJ Hampshire showed continued improvement. He passed Aaron Plessinger for third and remained there until the checkers.
Plessinger continued to fade in the closing laps to elevate fourth-place Justin Cooper and Chase Sexton into the top five.
Ducati debuted this round with Tony Cairoli finishing ninth.
In Race Notes
Jett Lawrence took the lead early in his quest to keep his perfect season alive.
Hunter Lawrence was running a distant second at the halfway mark with seven seconds separating him from Jett as Eli Tomac started to close the gap. The bad news is that his bike was smoking at the time.
Tomac was running third with nine minutes on the clock when his bike expired.
Tomac’s departure shifts the focus to the battle for the podium between RJ Hampshire and Aaron Plessinger.
With two minutes on the clock, it gets resolved in Hampshire’s favor.
Justin Cooper joins the battle with Plessinger and takes fifth.
In his return to the field, Chase Sexton was sixth.
More SuperMotocross News
RedBud 450 Qualification
RedBud Preview | Betting Guide
Chase Sexton set to return at RedBud
Southwick 450 results | 250 results
Motocross community mourns the death of Aidan Zingg
Jett Lawrence sweeps Southwick for fifth win of 2025
Haiden Deegan earns truly perfect round at Southwick
Jett Lawrence runs away from field in Southwick Moto 1
Haiden Deegan wins Southwick Moto 1 by 25 seconds
Justin Barcia to return from knee injury in Southwick
Drew Adams sidelined with broken finger
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How to increase your Porter Grade in Death Stranding 2? | Esports News
Struggling to level up your Porter Grade in Death Stranding 2? You’re not alone. This system quietly tracks your performance, shaping your upgrades, titles, and online influence. Whether you’re hauling packages up snowy slopes or sneaking past MULEs, every action counts. Here’s a breakdown of how to boost each of the five core categories and become a legendary Porter, without wasting hours in trial and error.
How to Increase Porter Grade in Death Stranding 2 ?Think of your Porter Grade as a personalized report card. Every delivery you complete contributes points to five different stats:
- Porter
- Combat
- Stealth
- Servicemanship
- Bridge Link
Together, they define your reputation and unlock upgrades tailored to your playstyle. The key? Focused, repeatable actions. If you want to level up your porter grade, then you need to level up these five stats:
1. Leveling Up Porter
Want to boost your Porter stat?
- Take on heavy or long-distance delivery orders.
- Prioritize S-rank deliveries—speed, cargo condition, and route efficiency matter.
- Carry items manually rather than relying solely on vehicles or bots.
Tip: Add extra cargo to orders if available. The more weight you carry, the faster this stat climbs.
2. Leveling Up Combat
This isn’t a stealth-only game. To grow your Combat stat:
- Engage in direct battles with MULEs or terrorists.
- Accept missions that involve hostile zones or retrieval from enemy camps.
- Use lethal or non-lethal weapons depending on your style.
Tip: Don’t run past enemies every time. Taking them head-on (and winning) rewards you handsomely here.
3. Leveling Up Stealth
Going unnoticed pays off. Here’s how to level Stealth:
- Avoid detection during deliveries through enemy-occupied territories.
- Use cover, terrain, and gadgets like chiral crystals to bypass foes.
- Quietly take down enemies without alerting others.
Tip: Complete stealth orders with zero alerts for max gains.
4. Leveling Up Servicemanship
This one’s all about being the helpful postman. To increase Servicemanship:
- Return Lost Cargo and complete Aid Requests.
- Maintain high delivery scores (damage-free, timely deliveries).
- Visit and assist remote or neglected facilities—they reward more points.
Tip: Sort your map for Lost Cargo regularly. These small gestures stack up fast.
5. Leveling Up Bridge Link
This is the trickiest stat—but also the most rewarding. To build Bridge Link:
- Create useful structures—ladders, ziplines, bridges.
- Contribute to shared roads or upgrades.
- Like, share, and use player-generated content.
Tip: Place signs at chokepoints or rest spots. Every time another player interacts, you gain Likes.
Why Should You Increase
Porter Grade in Death Stranding 2 ?- Unlock APAS Enhancements based on your stat priorities—combat scanners, stealth boosts, carrying efficiency.
- Earn unique nicknames like “Silent Carrier” or “Tactical Mover” that reflect your gameplay.
- Aim for the ‘Premier Porter’ trophy: reach level 40 in all five stats. It’s a grind—but doable.
Play your way, but play smart. Mix up your mission types, interact with the world, and don’t ignore the side content. The road to being a top-tier Porter isn’t just about surviving—it’s about delivering with purpose.
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- Porter
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Wimbledon 2025: Full order of play, Sunday 6 July
Britain’s last remaining hope in the women’s singles, Sonay Kartal, is first up on Centre Court on day seven of Wimbledon 2025.
Kartal, who is enjoying her best run in a Grand Slam, will look to extend her dream run into the second week when she faces Tokyo 2020 mixed doubles gold medallist Anastasia Pavlyuchenkova on Sunday (6 July).
Next up on Centre Court is world number one Aryna Sabalenka. Fresh from dispatching Emma Raducanu, the two-time Australian Open champion now faces Belgium’s Elise Mertens.
Two-time reigning Wimbledon men’s singles champion Carlos Alcaraz ends the Centre Court action on Sunday. He takes on 14th seed Andrey Rublev, who won gold in Tokyo with Pavlyuchenkova. The pair met twice in 2024 with a win apiece, but the Spaniard leads 2-1 in the head-to-head.
Also in action on Sunday are USA’s fifth seed Taylor Fritz, incoming top 10 debutant Amanda Anisimova, and Cameron Norrie who flies the flag for the home nation in the men’s singles.
Read on to find out the start times and all the matches at the Championships.
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ctDNA-Guided Surveillance Leads to Increased Curative-Intent Treatment After Recurrence in Nonmetastatic CRC
ctDNA-Guided Surveillance in CRC
| Image Credit: © Ashling Wahner
& MJH Life Sciences Using AIThe use of circulating tumor DNA (ctDNA)–guided surveillance led to earlier recurrence detection and an increased use of curative-intent treatment after recurrence compared with standard surveillance in patients with nonmetastatic colorectal cancer (CRC), according to data from the phase 3 FIND trial (NCT05904665) presented at the 2025 ESMO Gastrointestinal Cancers Congress.
Findings demonstrated that in the ctDNA surveillance arm (n = 289) and the control arm (n = 295), the recurrence rates were 8.3% and 10.5% respectively. Among patients who experienced disease recurrence, 50% (95% CI, 31.4%-68.6%) of patients in the ctDNA arm (n = 24) received curative-intent treatment compared with 22.6% (95% CI, 11.4%-39.8%) of patients in the standard surveillance arm (n = 31; relative risk, 2.214; 95% CI, 1.060-4.780; P = .034).
“The FIND trial methodology demonstrates the feasibility of a ctDNA methylation assay with a clinically actionable turnaround time for reporting results to guide surveillance decisions [in nonmetastatic CRC],” lead study author Junjie Peng, MD, said in a presentation of the late-breaking abstract. Peng is chief physician and professor in the Department of Colorectal Surgery at Fudan University Shanghai Cancer Center in China.
What Investigators Hoped to FIND
Following surgical resection, surveillance is vital to detect recurrence of nonmetastatic CRC and to allow for timely intervention; however, Peng explained that prior data have shown that approximately 20% of patients who experience recurrence detected via surveillance have the opportunity for surgical treatment with curative intent.
To assess the feasibility of ctDNA monitoring as a surveillance tool, the prospective, randomized FIND trial enrolled patients with at least 18 years of age with nonmetastatic CRC who had an ECOG performance status of 0 to 2, were candidates for curative-intent surgery, and had a life expectancy of at least 12 months.
Patients were randomly assigned 1:1 between the two arms. In the control arm, patients underwent surgery and standard surveillance, which comprised physical examination and CEA testing; CT scans of the chest, abdomen, and pelvis; and colonoscopy, as per the National Comprehensive Cancer Network Guidelines.
In the experimental arm, ctDNA testing occurred within 1 month prior to surgery, then every 3 months for 2 years. If patients in this cohort tested positive for ctDNA, they underwent an immediate CT scan or MRI; if the scan was also positive, a multidisciplinary team (MDT) determined the next course of treatment. If the CT scan or MRI was negative, patients received 2 subsequent scans within the following 6 months. A positive scan would lead to an MDT discussion, and if both subsequent scans were also negative, the patient would return to the ctDNA monitoring protocol. The imaging process was triggered by any positive ctDNA test.
ctDNA testing was conducted using an improved single-tube, methylation-specific assay designed to detect 10 methylation markers with the ability to detect ctDNA down to a 0.01% allele fraction.
The primary end point was the proportion of patients receiving curative-intent therapy. Secondary end points included time to clinical recurrence (TTCR), disease-free survival, overall survival, and health-related quality of life.
Patient Population
Among 795 screened patients, 728 were randomly assigned between the 2 arms. In the 363 patients assigned to the ctDNA group, 74 did not undergo monitoring due to stage IV disease (n = 18), a diagnosis of advanced adenoma (n = 6), a non-CRC diagnosis (n = 9), and no surgery performed (n = 41). Of the 365 patients assigned to standard surveillance, 70 did not undergo postoperative follow-up due to stage IV disease (n = 16), a diagnosis of advanced adenoma (n = 8), a non-CRC diagnosis (n = 7), and no surgery performed (n = 39).
A total of 289 patients in the ctDNA arm and 295 patients in the surveillance arm were included in the intention-to-treat (ITT) population; 25 patients and 11 patients, respectively, were not included in the per-protocol population due to violations.
In the ITT population, patients ranged in age from 18 to 44 years (ctDNA arm, 6.9%; surveillance arm, 10.5%), 45 to 64 years (59.2%; 52.5%), 65 to 74 years (29.4%; 31.2%), and 75 years and over (4.5%; 5.8%). The majority of patients did not receive neoadjuvant therapy (86.2%; 88.8%) and had rectal tumors (45.7%; 45.4%). TNM stages included stage I (20.4%; 20%), stage II (36%; 36.9%), stage III (39.1%; 39.7%), and PCR (4.5%; 3.4%). A small proportion of patients in both arms had microsatellite instability–high/mismatch repair–deficient disease (7.3%; 7.5%). Notable alterations included BRAF V600E mutations (2.7%; 2%), KRAS mutations (47.5%; 51.6%), and NRAS mutations (3.8%; 5.1%).
Wading Into Recurrence Data
Patients in the recurrence population had ages ranging from 18 to 44 years (ctDNA arm, 8.3%; surveillance arm, 16.1%), 45 to 64 years (70.8%; 51.6%), and 65 to 74 years (20.8%; 32.3%). Most did not receive neoadjuvant therapy (87.5%; 87.1%). TNM stages included stage I (8.3%; 6.5%), stage II (33.3%; 25.8%), stage III (58.3%; 61.3%), and PCR (0%; 6.5%). Patients had rectal tumors (58.3%; 38.7%), left-sided tumors (37.5%; 38.7%), and right-sided tumors (4.2%; 22.6%). Most patients had adenocarcinoma (91.7%; 89.7%), with a small proportion of patients presenting with mucinosis adenocarcinoma (4.2%; 10.3%) and signet ring cell carcinoma (4.2%; 0%). BRAF/RAS mutations included BRAF V600E (4.2%; 3.6%), KRAS (58.3%; 50%), and NRAS (8.3%; 3.6%).
The median TTCR was 9 months (interquartile range [IQR]), 4.5-11) in the ctDNA arm vs 12 months (IQR, 11-13) in the control arm (lead time, 3.05 months; 95% CI, 1.43-4.67; P < .001). In the ctDNA group, the lead time rates at no more than 2 months, no more than 4 months, and less than 8 months were 24%, 52%, and 75%, respectively.
Regarding recurrent lesions, 62.5% of patients in the ctDNA group had liver and/or lung lesions only vs 51.6% of patients in the surveillance arm. Eleven of 15 patients in the ctDNA arm and 5 of 16 patients in the surveillance arm with only liver and/or lung lesions received curative-intent treatment. Locoregional recurrence was reported in 4.2% of patients in the ctDNA arm and 9.7% of patients in the surveillance group. The lone patient with locoregional recurrence in the ctDNA received curative-intent treatment vs 1 of 3 patients in the control arm.
Other metastatic sites were reported in 33.3% of patients whose disease recurred in the ctDNA arm vs 38.7% of patients in the surveillance arm. No patients in the ctDNA arm received curative-intent treatment for other metastatic sites vs 1 of 12 patients in the surveillance arm.
Among patients with liver metastases in the ctDNA arm (n = 9) and surveillance arm (n = 7), most had 3 or fewer lesions (88.9%; 42.9%). Notably, 77.8% of patients in the ctDNA arm had a tumor size of 3 cm or less vs 42.9% of patients in the control arm. The rates of patients with unilobar lesions were 88.9% and 42.9%, respectively.
“Our ctDNA-guided surveillance identified earlier recurrences amendable to curative therapy at higher rates than standard surveillance, predominantly [with] localized lung/liver metastases,” Peng concluded.
Disclosures: Study co-author Chunming Ding, PhD, is the founder for Innovation Biomed and has filed patent applications for the assay used during the trail study. The remaining study authors did not have any financial disclosures.
Reference
Peng J, Ding C, Mo S, et al. Dynamic circulating tumor DNA methylation monitoring guiding postoperative surveillance in non-metastatic colorectal cancer: Interim analysis of FIND trial. Presented at: 2025 ESMO Gastrointestinal Cancers Congress; July 2-5, 2025; Barcelona, Spain. Abstract LBA1.
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PM expresses grief over deaths due to flash floods in US – RADIO PAKISTAN
- PM expresses grief over deaths due to flash floods in US RADIO PAKISTAN
- Meteorologists Say the National Weather Service Did Its Job in Texas WIRED
- 15 children are among the dead from Texas flash floods as rescuers search for the missing AP News
- 27 people confirmed dead as flood waters recede in US state of Texas Dawn
- Texas Flooding Toll Climbs Over 40; Two Dozen Still Missing From Camp Mystic The Weather Channel
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